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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:corosolic acid
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Accession:CHEBI:67895 term browser browse the term
Definition:A triterpenoid that has formula C30H48O4.
Synonyms:related_synonym: 2alpha-Hydroxyursolic acid;   Colosic acid;   Formula=C30H48O4;   Glucosol;   InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1;   InChIKey=HFGSQOYIOKBQOW-ZSDYHTTISA-N;   SMILES=[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)C[C@@H](O)[C@H](O)C2(C)C;   Urs-12-en-28-oic acid, 2,3-dihydroxy-, (2alpha,3beta)-
 xref: CAS:4547-24-4
 xref_mesh: MESH:C113861
 xref: PMID:21288041;   PMID:21309591;   PMID:21443171



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corosolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
corosolic acid inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; corosolic acid inhibits the reaction [Ethanol results in increased expression of BAX protein]; PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
corosolic acid results in increased expression of BAX mRNA; corosolic acid results in increased expression of BAX protein
CTD PMID:26033013 PMID:28506699 PMID:34296331 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
corosolic acid results in decreased expression of BCL2 mRNA; corosolic acid results in decreased expression of BCL2 protein
corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
CTD PMID:28506699 PMID:34296331 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Becn1 beclin 1 multiple interactions ISO corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BECN1 protein] CTD PMID:34296331 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO corosolic acid results in increased expression of BIRC5 protein CTD PMID:28506699 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases expression
EXP
ISO
corosolic acid inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]
corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]
corosolic acid results in increased cleavage of CASP3 protein
corosolic acid results in decreased expression of CASP3 mRNA
CTD PMID:26033013 PMID:28506699 PMID:34296331 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO corosolic acid promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDK1 mRNA] CTD PMID:32135139 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Ctnnb1 catenin beta 1 increases degradation ISO corosolic acid results in increased degradation of CTNNB1 protein CTD PMID:24566423 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA] CTD PMID:26513295 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL1 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL1 mRNA] CTD PMID:26513295 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP
ISO
corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CYBB protein]; PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CYBB protein]]
corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CYBB mRNA]; corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CYBB protein]
CTD PMID:34296331 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CYP27B1 mRNA] CTD PMID:32135139 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein decreases expression ISO corosolic acid results in decreased expression of DIABLO mRNA; corosolic acid results in decreased expression of DIABLO protein CTD PMID:28506699 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of DKK2 mRNA] CTD PMID:32135139 NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225
JBrowse link
G Dock8 dedicator of cytokinesis 8 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of DOCK8 mRNA] CTD PMID:32135139 NCBI chr 1:222,649,309...222,842,474
Ensembl chr 1:222,649,309...222,842,474
JBrowse link
G Dusp22 dual specificity phosphatase 22 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of DUSP22 gene] CTD PMID:32135139 NCBI chr17:33,780,980...33,831,540
Ensembl chr17:33,780,981...33,831,321
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO corosolic acid results in decreased expression of FAS mRNA; corosolic acid results in decreased expression of FAS protein CTD PMID:28506699 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gdf11 growth differentiation factor 11 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF11 mRNA] CTD PMID:32135139 NCBI chr 7:1,311,732...1,325,211
Ensembl chr 7:1,311,732...1,320,725
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IGF1R protein] CTD PMID:26513295 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il17a interleukin 17A multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA] CTD PMID:26513295 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of JUN protein]; corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein] CTD PMID:26513295 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO
EXP
corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein]
corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein]]
CTD PMID:34296331 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Madd MAP-kinase activating death domain multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of MADD gene] CTD PMID:32135139 NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA] CTD PMID:32135139 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions ISO corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of ATP6 mRNA] CTD PMID:34296331 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO corosolic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of MTOR protein] CTD PMID:34296331 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO corosolic acid results in increased expression of NFKBIA mRNA
corosolic acid results in increased expression of and results in decreased phosphorylation of NFKBIA protein
CTD PMID:28506699 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 mRNA] CTD PMID:32135139 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO corosolic acid inhibits the reaction [Doxorubicin results in increased expression of NOX4 mRNA] CTD PMID:34296331 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nsg2 neuronal vesicle trafficking associated 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of NSG2 gene] CTD PMID:32135139 NCBI chr10:15,601,594...15,661,441
Ensembl chr10:15,601,596...15,661,441
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 multiple interactions EXP corosolic acid inhibits the reaction [Ethanol results in increased expression of ORAI1 protein] CTD PMID:26033013 NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405
JBrowse link
G Pdcd4 programmed cell death 4 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PDCD4 protein] CTD PMID:26513295 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions ISO corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of PDK4 mRNA] CTD PMID:34296331 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 decreases response to substance
multiple interactions
ISO
EXP
PRKAA2 gene mutant form results in decreased susceptibility to corosolic acid
PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CYBB protein]]
CTD PMID:34296331 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:26513295 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rassf2 Ras association domain family member 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of RASSF2 gene] CTD PMID:32135139 NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
ISO corosolic acid results in decreased expression of RELA mRNA
corosolic acid results in decreased expression of and affects the localization of RELA protein
CTD PMID:28506699 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of SLC2A1 mRNA] CTD PMID:34296331 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of SLC2A4 mRNA] CTD PMID:34296331 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene] CTD PMID:32135139 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO
EXP
corosolic acid inhibits the reaction [Doxorubicin results in increased expression of SQSTM1 protein]
corosolic acid inhibits the reaction [Doxorubicin results in increased expression of SQSTM1 protein]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of SQSTM1 protein]]
CTD PMID:34296331 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein] CTD PMID:26513295 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein] CTD PMID:26513295 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stim1 stromal interaction molecule 1 multiple interactions EXP corosolic acid inhibits the reaction [Ethanol results in increased expression of STIM1 protein] CTD PMID:26033013 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363
JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein] CTD PMID:26513295 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Tasp1 taspase 1 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of TASP1 gene] CTD PMID:32135139 NCBI chr 3:127,176,416...127,408,039
Ensembl chr 3:127,176,692...127,399,600
JBrowse link
G Tfeb transcription factor EB increases response to substance
multiple interactions
EXP TFEB protein results in increased susceptibility to corosolic acid
TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of SQSTM1 protein]]
CTD PMID:34296331 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO corosolic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of ULK1 protein] CTD PMID:34296331 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
G Uri1 URI1, prefoldin-like chaperone multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of URI1 gene] CTD PMID:32135139 NCBI chr 1:90,646,392...90,704,811
Ensembl chr 1:90,646,393...90,709,026
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] CTD PMID:26513295 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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  CHEBI ontology 19659
    role 19634
      biological role 19633
        biochemical role 19388
          metabolite 19333
            corosolic acid 49
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            organic hydride 18546
                              organic fundamental parent 18582
                                hydrocarbon 18313
                                  terpene 13645
                                    triterpene 777
                                      triterpenoid 772
                                        corosolic acid 49
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