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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:corosolic acid
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Accession:CHEBI:67895 term browser browse the term
Definition:A triterpenoid that has formula C30H48O4.
Synonyms:related_synonym: 2alpha-Hydroxyursolic acid;   Colosic acid;   Formula=C30H48O4;   Glucosol;   InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1;   InChIKey=HFGSQOYIOKBQOW-ZSDYHTTISA-N;   SMILES=[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)C[C@@H](O)[C@H](O)C2(C)C;   Urs-12-en-28-oic acid, 2,3-dihydroxy-, (2alpha,3beta)-
 xref: CAS:4547-24-4
 xref_mesh: MESH:C113861
 xref: PMID:21288041;   PMID:21309591;   PMID:21443171


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corosolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
corosolic acid inhibits the reaction [Ethanol results in increased expression of BAX protein]
corosolic acid results in increased expression of BAX mRNA; corosolic acid results in increased expression of BAX protein
CTD PMID:26033013, PMID:28506699 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO corosolic acid results in decreased expression of BCL2 mRNA; corosolic acid results in decreased expression of BCL2 protein CTD PMID:28506699 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO corosolic acid results in increased expression of BIRC5 protein CTD PMID:28506699 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases expression
EXP
ISO
corosolic acid inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]
corosolic acid results in increased cleavage of CASP3 protein
corosolic acid results in decreased expression of CASP3 mRNA
CTD PMID:26033013, PMID:28506699 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO corosolic acid promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDK1 mRNA] CTD PMID:32135139 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Ctnnb1 catenin beta 1 increases degradation ISO corosolic acid results in increased degradation of CTNNB1 protein CTD PMID:24566423 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA] CTD PMID:26513295 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL1 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL1 mRNA] CTD PMID:26513295 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CYP27B1 mRNA] CTD PMID:32135139 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein decreases expression ISO corosolic acid results in decreased expression of DIABLO mRNA; corosolic acid results in decreased expression of DIABLO protein CTD PMID:28506699 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of DKK2 mRNA] CTD PMID:32135139 NCBI chr 2:237,148,918...237,240,883
Ensembl chr 2:237,148,941...237,241,350
JBrowse link
G Dock8 dedicator of cytokinesis 8 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of DOCK8 mRNA] CTD PMID:32135139 NCBI chr 1:242,934,685...243,153,472
Ensembl chr 1:242,959,488...243,153,465
JBrowse link
G Dusp22 dual specificity phosphatase 22 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of DUSP22 gene] CTD PMID:32135139 NCBI chr17:34,986,589...35,037,297
Ensembl chr17:34,986,591...35,037,076
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO corosolic acid results in decreased expression of FAS mRNA; corosolic acid results in decreased expression of FAS protein CTD PMID:28506699 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Gdf11 growth differentiation factor 11 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF11 mRNA] CTD PMID:32135139 NCBI chr 7:3,306,863...3,315,856
Ensembl chr 7:3,306,863...3,315,856
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IGF1R protein] CTD PMID:26513295 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il17a interleukin 17A multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA] CTD PMID:26513295 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il22 interleukin 22 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA] CTD PMID:26513295 NCBI chr 7:61,236,037...61,240,502
Ensembl chr 7:61,236,037...61,240,502
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of JUN protein]; corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein] CTD PMID:26513295 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Madd MAP-kinase activating death domain multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of MADD gene] CTD PMID:32135139 NCBI chr 3:79,960,301...80,003,023
Ensembl chr 3:79,960,301...80,003,032
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA] CTD PMID:32135139 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO corosolic acid results in increased expression of NFKBIA mRNA
corosolic acid results in increased expression of and results in decreased phosphorylation of NFKBIA protein
CTD PMID:28506699 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 mRNA] CTD PMID:32135139 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nsg2 neuronal vesicle trafficking associated 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of NSG2 gene] CTD PMID:32135139 NCBI chr10:15,867,885...15,928,169
Ensembl chr10:15,867,887...15,928,169
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 multiple interactions EXP corosolic acid inhibits the reaction [Ethanol results in increased expression of ORAI1 protein] CTD PMID:26033013 NCBI chr12:38,981,903...38,995,570
Ensembl chr12:38,981,927...38,995,570
JBrowse link
G Pdcd4 programmed cell death 4 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PDCD4 protein] CTD PMID:26513295 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:26513295 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rassf2 Ras association domain family member 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of RASSF2 gene] CTD PMID:32135139 NCBI chr 3:124,574,088...124,610,267
Ensembl chr 3:124,575,621...124,610,267
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
ISO corosolic acid results in decreased expression of RELA mRNA
corosolic acid results in decreased expression of and affects the localization of RELA protein
CTD PMID:28506699 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene] CTD PMID:32135139 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein] CTD PMID:26513295 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein] CTD PMID:26513295 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stim1 stromal interaction molecule 1 multiple interactions EXP corosolic acid inhibits the reaction [Ethanol results in increased expression of STIM1 protein] CTD PMID:26033013 NCBI chr 1:167,373,894...167,533,412
Ensembl chr 1:167,373,678...167,533,420
JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein] CTD PMID:26513295 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Tasp1 taspase 1 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of TASP1 gene] CTD PMID:32135139 NCBI chr 3:132,888,785...133,131,213
Ensembl chr 3:132,888,772...133,131,192
JBrowse link
G Uri1 URI1, prefoldin-like chaperone multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of URI1 gene] CTD PMID:32135139 NCBI chr 1:94,346,513...94,404,362
Ensembl chr 1:94,346,514...94,404,211
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] CTD PMID:26513295 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            corosolic acid 37
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  terpene 9593
                                    triterpene 665
                                      triterpenoid 661
                                        corosolic acid 37
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.