Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:corosolic acid
go back to main search page
Accession:CHEBI:67895 term browser browse the term
Definition:A triterpenoid that has formula C30H48O4.
Synonyms:related_synonym: 2alpha-Hydroxyursolic acid;   Colosic acid;   Formula=C30H48O4;   Glucosol;   InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1;   InChIKey=HFGSQOYIOKBQOW-ZSDYHTTISA-N;   SMILES=[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)C[C@@H](O)[C@H](O)C2(C)C;   Urs-12-en-28-oic acid, 2,3-dihydroxy-, (2alpha,3beta)-
 xref: CAS:4547-24-4
 xref_mesh: MESH:C113861
 xref: PMID:21288041;   PMID:21309591;   PMID:21443171


show annotations for term's descendants           Sort by:
 
corosolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
corosolic acid inhibits the reaction [Ethanol results in increased expression of BAX protein]
corosolic acid results in increased expression of BAX mRNA; corosolic acid results in increased expression of BAX protein
CTD PMID:26033013 PMID:28506699 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO corosolic acid results in decreased expression of BCL2 mRNA; corosolic acid results in decreased expression of BCL2 protein CTD PMID:28506699 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO corosolic acid results in increased expression of BIRC5 protein CTD PMID:28506699 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases expression
EXP
ISO
corosolic acid inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]
corosolic acid results in increased cleavage of CASP3 protein
corosolic acid results in decreased expression of CASP3 mRNA
CTD PMID:26033013 PMID:28506699 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO corosolic acid promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDK1 mRNA] CTD PMID:32135139 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Ctnnb1 catenin beta 1 increases degradation ISO corosolic acid results in increased degradation of CTNNB1 protein CTD PMID:24566423 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA] CTD PMID:26513295 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL1 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL1 mRNA] CTD PMID:26513295 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CYP27B1 mRNA] CTD PMID:32135139 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein decreases expression ISO corosolic acid results in decreased expression of DIABLO mRNA; corosolic acid results in decreased expression of DIABLO protein CTD PMID:28506699 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of DKK2 mRNA] CTD PMID:32135139 NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225
JBrowse link
G Dock8 dedicator of cytokinesis 8 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of DOCK8 mRNA] CTD PMID:32135139 NCBI chr 1:222,649,309...222,842,474
Ensembl chr 1:222,649,309...222,842,474
JBrowse link
G Dusp22 dual specificity phosphatase 22 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of DUSP22 gene] CTD PMID:32135139 NCBI chr17:33,780,980...33,831,540
Ensembl chr17:33,780,981...33,831,321
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO corosolic acid results in decreased expression of FAS mRNA; corosolic acid results in decreased expression of FAS protein CTD PMID:28506699 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gdf11 growth differentiation factor 11 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF11 mRNA] CTD PMID:32135139 NCBI chr 7:1,311,732...1,325,211
Ensembl chr 7:1,311,732...1,320,725
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IGF1R protein] CTD PMID:26513295 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il17a interleukin 17A multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA] CTD PMID:26513295 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of JUN protein]; corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein] CTD PMID:26513295 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Madd MAP-kinase activating death domain multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of MADD gene] CTD PMID:32135139 NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA] CTD PMID:32135139 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO corosolic acid results in increased expression of NFKBIA mRNA
corosolic acid results in increased expression of and results in decreased phosphorylation of NFKBIA protein
CTD PMID:28506699 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 mRNA] CTD PMID:32135139 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nsg2 neuronal vesicle trafficking associated 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of NSG2 gene] CTD PMID:32135139 NCBI chr10:15,601,594...15,661,441
Ensembl chr10:15,601,596...15,661,441
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 multiple interactions EXP corosolic acid inhibits the reaction [Ethanol results in increased expression of ORAI1 protein] CTD PMID:26033013 NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405
JBrowse link
G Pdcd4 programmed cell death 4 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PDCD4 protein] CTD PMID:26513295 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:26513295 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rassf2 Ras association domain family member 2 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of RASSF2 gene] CTD PMID:32135139 NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
ISO corosolic acid results in decreased expression of RELA mRNA
corosolic acid results in decreased expression of and affects the localization of RELA protein
CTD PMID:28506699 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene] CTD PMID:32135139 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein] CTD PMID:26513295 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein] CTD PMID:26513295 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stim1 stromal interaction molecule 1 multiple interactions EXP corosolic acid inhibits the reaction [Ethanol results in increased expression of STIM1 protein] CTD PMID:26033013 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363
JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein] CTD PMID:26513295 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Tasp1 taspase 1 multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of TASP1 gene] CTD PMID:32135139 NCBI chr 3:127,176,416...127,408,039
Ensembl chr 3:127,176,692...127,399,600
JBrowse link
G Uri1 URI1, prefoldin-like chaperone multiple interactions ISO corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of URI1 gene] CTD PMID:32135139 NCBI chr 1:90,646,392...90,704,811
Ensembl chr 1:90,646,393...90,709,026
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] CTD PMID:26513295 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            corosolic acid 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  terpene 12711
                                    triterpene 737
                                      triterpenoid 732
                                        corosolic acid 36
paths to the root