corosolic acid - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	corosolic acid	go back to main search page
Accession:	CHEBI:67895	browse the term
Definition:	A triterpenoid that has formula C30H48O4.
Synonyms:	related_synonym:	2alpha-Hydroxyursolic acid; Colosic acid; Formula=C30H48O4; Glucosol; InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1; InChIKey=HFGSQOYIOKBQOW-ZSDYHTTISA-N; SMILES=[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)C[C@@H](O)[C@H](O)C2(C)C; Urs-12-en-28-oic acid, 2,3-dihydroxy-, (2alpha,3beta)-
	xref:	CAS:4547-24-4
	xref_mesh:	MESH:C113861
	xref:	PMID:21288041; PMID:21309591; PMID:21443171

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Genes (434)

corosolic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases expression

corosolic acid results in increased expression of A2M mRNA

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786

G

actinin, alpha 1

increases expression

corosolic acid results in increased expression of ACTN1 mRNA

NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:98,998,556...99,093,251

G

adhesion G protein-coupled receptor G1

increases expression

corosolic acid results in increased expression of ADGRG1 mRNA

NCBI chr19:10,009,983...10,047,138
Ensembl chr19:10,003,975...10,041,108

G

AFG3 like matrix AAA peptidase subunit 2

decreases expression

corosolic acid results in decreased expression of AFG3L2 mRNA

NCBI chr18:63,224,163...63,269,000
Ensembl chr18:60,954,268...60,999,110

G

alpha-fetoprotein

increases expression

corosolic acid results in increased expression of AFP mRNA

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480

G

agrin

increases expression

corosolic acid results in increased expression of AGRN mRNA

NCBI chr 5:172,031,528...172,064,429
Ensembl chr 5:166,749,310...166,786,003

G

alpha-2-HS-glycoprotein

increases expression

corosolic acid results in increased expression of AHSG mRNA

NCBI chr11:91,625,975...91,632,583
Ensembl chr11:78,117,918...78,145,999

G

apoptosis inducing factor, mitochondria associated 1

decreases expression

corosolic acid results in decreased expression of AIFM1 mRNA

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:127,650,226...127,689,256

G

A-kinase anchoring protein 8

increases expression

corosolic acid results in increased expression of AKAP8 mRNA

NCBI chr 7:11,966,769...11,983,056
Ensembl chr 7:11,316,228...11,332,399

G

albumin

increases expression

corosolic acid results in increased expression of ALB mRNA

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

ALG3, alpha-1,3- mannosyltransferase

increases expression

corosolic acid results in increased expression of ALG3 mRNA

NCBI chr11:93,804,859...93,810,403
Ensembl chr11:80,300,498...80,307,912

G

ankyrin 1

increases expression

corosolic acid results in increased expression of ANK1 mRNA

NCBI chr16:75,578,824...75,757,464
Ensembl chr16:68,877,504...69,054,759

G

ankyrin repeat and LEM domain containing 2

increases expression

corosolic acid results in increased expression of ANKLE2 mRNA

NCBI chr12:52,077,863...52,110,775
Ensembl chr12:46,417,759...46,500,514

G

ankyrin repeat domain 22

increases expression

corosolic acid results in increased expression of ANKRD22 mRNA

NCBI chr 1:241,052,235...241,083,737
Ensembl chr 1:231,639,314...231,670,381

G

ankyrin repeat domain 52

decreases expression

corosolic acid results in decreased expression of ANKRD52 mRNA

NCBI chr 7:806,829...820,481
Ensembl chr 7:806,767...820,481

G

anillin, actin binding protein

decreases expression

corosolic acid results in decreased expression of ANLN mRNA; corosolic acid results in decreased expression of ANLN protein

NCBI chr 8:29,134,222...29,197,513
Ensembl chr 8:20,858,228...20,921,538

G

adaptor related protein complex 1 subunit mu 2

decreases expression

corosolic acid results in decreased expression of AP1M2 mRNA

NCBI chr 8:28,114,748...28,132,767
Ensembl chr 8:19,838,580...19,856,482

G

apolipoprotein A1

increases expression

corosolic acid results in increased expression of APOA1 mRNA

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein C3

increases expression

corosolic acid results in increased expression of APOC3 mRNA

NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:46,531,478...46,533,583

G

apolipoprotein E

increases expression

corosolic acid results in increased expression of APOE mRNA

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932

G

apolipoprotein M

increases expression

corosolic acid results in increased expression of APOM mRNA

NCBI chr20:3,695,618...3,698,218
Ensembl chr20:3,688,413...3,693,550

G

amyloid beta precursor protein

increases expression

corosolic acid results in increased expression of APP mRNA

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

corosolic acid results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:35,785,237...35,803,423

G

ATP synthase F1 subunit alpha

decreases expression

corosolic acid results in decreased expression of ATP5F1A mRNA

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794

G

ATP synthase F1 subunit delta

decreases expression

corosolic acid results in decreased expression of ATP5F1D mRNA

NCBI chr 7:10,211,260...10,218,989
Ensembl chr 7:9,560,608...9,565,929

G

ATP synthase F1 subunit epsilon

decreases expression

corosolic acid results in decreased expression of ATP5F1E mRNA

NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:163,260,476...163,261,450

G

ATP synthase inhibitory factor subunit 1

decreases expression

corosolic acid results in decreased expression of ATP5IF1 mRNA

NCBI chr 5:150,022,960...150,026,677
Ensembl chr 5:144,738,950...144,742,668

G

ATP synthase peripheral stalk subunit d

decreases expression

corosolic acid results in decreased expression of ATP5PD mRNA

NCBI chr10:101,156,673...101,161,926
Ensembl chr10:100,657,708...100,663,479

G

ATP synthase peripheral stalk subunit F6

decreases expression

corosolic acid results in decreased expression of ATP5PF mRNA

NCBI chr11:37,368,045...37,375,721
Ensembl chr11:23,881,592...23,889,119

G

ATP synthase peripheral stalk subunit OSCP

decreases expression

corosolic acid results in decreased expression of ATP5PO mRNA

NCBI chr11:44,651,171...44,657,483
Ensembl chr11:31,165,217...31,171,592

G

ATPase H+ transporting accessory protein 2

increases expression

corosolic acid results in increased expression of ATP6AP2 mRNA

NCBI chr X:12,856,708...12,883,670
Ensembl chr X:10,183,068...10,210,918

G

ATP synthase mitochondrial F1 complex assembly factor 2

decreases expression

corosolic acid results in decreased expression of ATPAF2 mRNA

NCBI chr10:45,705,157...45,721,282
Ensembl chr10:45,197,441...45,221,026

G

aurora kinase A

decreases expression

corosolic acid results in decreased expression of AURKA mRNA

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:161,128,313...161,144,390

G

aurora kinase B

decreases expression

corosolic acid results in decreased expression of AURKB mRNA; corosolic acid results in decreased expression of AURKB protein

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837

G

beta-1,4-galactosyltransferase 5

increases expression

corosolic acid results in increased expression of B4GALT5 mRNA

NCBI chr 3:176,437,073...176,453,001
Ensembl chr 3:156,018,053...156,070,074

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression
decreases expression

corosolic acid inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; corosolic acid inhibits the reaction [Ethanol results in increased expression of BAX protein]; PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
corosolic acid results in increased expression of BAX mRNA; corosolic acid results in increased expression of BAX protein
corosolic acid results in decreased expression of BAX mRNA

PMID:26033013 PMID:28506699 PMID:34296331 PMID:37939859

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

branched chain keto acid dehydrogenase E1 subunit beta

decreases expression

corosolic acid results in decreased expression of BCKDHB mRNA

NCBI chr 8:93,725,277...93,907,799
Ensembl chr 8:84,845,264...85,027,812

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

corosolic acid results in decreased expression of BCL2 mRNA; corosolic acid results in decreased expression of BCL2 protein
corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]

PMID:28506699 PMID:34296331

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

beclin 1

multiple interactions

corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BECN1 protein]

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

baculoviral IAP repeat-containing 5

increases expression

corosolic acid results in increased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

BLOC-1 related complex subunit 6

increases expression

corosolic acid results in increased expression of BORCS6 mRNA

NCBI chr10:54,259,349...54,261,203
Ensembl chr10:53,758,093...53,762,632

G

bromodomain containing 9

increases expression

corosolic acid results in increased expression of BRD9 mRNA

NCBI chr 1:31,158,546...31,185,812
Ensembl chr 1:29,329,985...29,357,016

G

BUD23, rRNA methyltransferase and ribosome maturation factor

decreases expression

corosolic acid results in decreased expression of BUD23 mRNA

NCBI chr12:27,266,093...27,277,300
Ensembl chr12:21,629,536...21,640,751

G

similar to human chromosome 6 open reading frame 120

increases expression

corosolic acid results in increased expression of C6ORF120 mRNA

NCBI chr 1:55,950,449...55,953,173
Ensembl chr 1:55,949,814...55,963,333

G

complement C1q binding protein

decreases expression

corosolic acid results in decreased expression of C1QBP mRNA

NCBI chr10:56,198,534...56,203,185
Ensembl chr10:55,699,954...55,704,649

G

complement C3

increases expression

corosolic acid results in increased expression of C3 mRNA

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429

G

complement C4A

increases expression

corosolic acid results in increased expression of C4A mRNA

NCBI chr20:4,010,306...4,024,707
Ensembl chr20:4,005,731...4,020,080

G

complement component 4 binding protein, alpha

increases expression

corosolic acid results in increased expression of C4BPA mRNA

NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205

G

complement C5

increases expression

corosolic acid results in increased expression of C5 mRNA

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994

G

complement C7

increases expression

corosolic acid results in increased expression of C7 mRNA

NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:54,088,116...54,158,535

G

cyclase associated actin cytoskeleton regulatory protein 2

increases expression

corosolic acid results in increased expression of CAP2 mRNA

NCBI chr17:18,260,462...18,409,681
Ensembl chr17:18,054,431...18,203,373

G

caspase 3

multiple interactions
decreases expression
increases cleavage

corosolic acid inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]
corosolic acid results in decreased expression of CASP3 mRNA
corosolic acid results in increased cleavage of CASP3 protein
corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]

PMID:26033013 PMID:28506699 PMID:34296331

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caveolin 1

decreases expression

corosolic acid results in decreased expression of CAV1 mRNA

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705

G

coiled-coil domain containing 175

increases expression

corosolic acid results in increased expression of CCDC175 mRNA

NCBI chr 6:90,661,948...90,745,015
Ensembl chr 6:90,662,269...90,744,963

G

coiled coil domain containing 88A

increases expression

corosolic acid results in increased expression of CCDC88A mRNA

NCBI chr14:107,304,654...107,456,104
Ensembl chr14:103,103,513...103,252,368

G

coiled-coil domain containing 97

increases expression

corosolic acid results in increased expression of CCDC97 mRNA

NCBI chr 1:90,347,003...90,354,809
Ensembl chr 1:81,219,230...81,226,986

G

cyclin A2

decreases expression

corosolic acid results in decreased expression of CCNA2 mRNA; corosolic acid results in decreased expression of CCNA2 protein

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

corosolic acid results in decreased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172

G

cell cycle progression 1

increases expression

corosolic acid results in increased expression of CCPG1 mRNA

NCBI chr 8:82,600,677...82,633,082
Ensembl chr 8:73,719,955...73,752,430

G

cell division cycle 20

decreases expression

corosolic acid results in decreased expression of CDC20 mRNA; corosolic acid results in decreased expression of CDC20 protein

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512

G

CDC42 effector protein 3

decreases expression

corosolic acid results in decreased expression of CDC42EP3 mRNA

NCBI chr 6:21,463,081...21,483,553
Ensembl chr 6:15,708,730...15,732,721

G

cyclin-dependent kinase 1

multiple interactions

corosolic acid promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDK1 mRNA]

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 16

increases expression

corosolic acid results in increased expression of CDK16 mRNA

NCBI chr X:4,046,330...4,057,825
Ensembl chr X:1,492,814...1,504,148

G

cyclin-dependent kinase 8

increases expression

corosolic acid results in increased expression of CDK8 mRNA

NCBI chr12:13,851,024...13,919,017
Ensembl chr12:8,737,262...8,804,177

G

cerebellar degeneration-related protein 2

decreases expression

corosolic acid results in decreased expression of CDR2 mRNA

NCBI chr 1:184,934,128...184,959,036
Ensembl chr 1:175,502,838...175,537,472

G

CCAAT/enhancer binding protein beta

increases expression

corosolic acid results in increased expression of CEBPB mRNA

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473

G

centromere protein Q

decreases expression

corosolic acid results in decreased expression of CENPQ mRNA

NCBI chr 9:27,454,339...27,469,371
Ensembl chr 9:19,957,048...19,972,789

G

centrosomal protein 192

increases expression

corosolic acid results in increased expression of CEP192 mRNA

NCBI chr18:63,643,816...63,728,264
Ensembl chr18:61,332,158...61,458,379

G

chromatin assembly factor 1 subunit B

decreases expression

corosolic acid results in decreased expression of CHAF1B mRNA

NCBI chr11:46,670,560...46,690,739
Ensembl chr11:33,200,981...33,221,070

G

checkpoint kinase 1

decreases expression

corosolic acid results in decreased expression of CHEK1 mRNA; corosolic acid results in decreased expression of CHEK1 protein

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009

G

charged multivesicular body protein 7

increases expression

corosolic acid results in increased expression of CHMP7 mRNA

NCBI chr15:51,200,759...51,215,992
Ensembl chr15:44,790,996...44,806,216

G

CDGSH iron sulfur domain 1

decreases expression

corosolic acid results in decreased expression of CISD1 mRNA

NCBI chr20:17,254,462...17,267,843
Ensembl chr20:17,255,151...17,284,924

G

CDC28 protein kinase regulatory subunit 1B

decreases expression

corosolic acid results in decreased expression of CKS1B mRNA

NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:174,833,050...174,837,636

G

claudin 1

increases expression

corosolic acid results in increased expression of CLDN1 mRNA

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:74,421,569...74,436,724

G

C-type lectin domain family 3, member B

increases expression

corosolic acid results in increased expression of CLEC3B mRNA

NCBI chr 8:131,687,575...131,693,292
Ensembl chr 8:122,810,149...122,815,835

G

calsyntenin 1

increases expression

corosolic acid results in increased expression of CLSTN1 mRNA

NCBI chr 5:165,314,128...165,377,627
Ensembl chr 5:160,031,308...160,094,583

G

cytochrome C oxidase assembly factor 3

decreases expression

corosolic acid results in decreased expression of COA3 mRNA

NCBI chr10:86,720,454...86,721,435
Ensembl chr10:86,220,194...86,221,178

G

cytochrome c oxidase assembly factor 7

decreases expression

corosolic acid results in decreased expression of COA7 mRNA

NCBI chr 5:123,069,356...123,080,942
Ensembl chr 5:123,069,371...123,080,199

G

collagen type I alpha 1 chain

increases expression

corosolic acid results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624

G

collagen type VI alpha 1 chain

increases expression

corosolic acid results in increased expression of COL6A1 mRNA

NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,957...11,924,597

G

collagen type VI alpha 3 chain

increases expression

corosolic acid results in increased expression of COL6A3 mRNA

NCBI chr 9:98,809,171...98,887,060
Ensembl chr 9:91,361,583...91,439,471

G

cartilage oligomeric matrix protein

increases expression

corosolic acid results in increased expression of COMP mRNA

NCBI chr16:19,081,172...19,089,548
Ensembl chr16:19,047,207...19,055,845

G

cytochrome c oxidase assembly homolog COX15

decreases expression

corosolic acid results in decreased expression of COX15 mRNA

NCBI chr 1:252,554,811...252,571,471
Ensembl chr 1:242,605,588...242,622,261

G

cytochrome c oxidase subunit 4i1

decreases expression

corosolic acid results in decreased expression of COX4I1 mRNA

NCBI chr19:65,630,383...65,636,623
Ensembl chr19:48,721,199...48,727,921

G

cytochrome c oxidase subunit 6B1

decreases expression

corosolic acid results in decreased expression of COX6B1 mRNA

NCBI chr 1:95,002,513...95,011,516
Ensembl chr 1:85,875,109...85,884,001
Ensembl chr 2:85,875,109...85,884,001
Ensembl chr 5:85,875,109...85,884,001

G

cytochrome c oxidase subunit 6C

decreases expression

corosolic acid results in decreased expression of COX6C mRNA

NCBI chr 7:69,014,410...69,027,145
Ensembl chr 7:67,111,024...67,141,963

G

cytochrome c oxidase subunit 7A2

decreases expression

corosolic acid results in decreased expression of COX7A2 mRNA

NCBI chr 8:89,597,051...89,611,032
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633

G

cytochrome c oxidase subunit 7B

decreases expression

corosolic acid results in decreased expression of COX7B mRNA

NCBI chr X:75,149,036...75,155,285
Ensembl chr X:71,083,456...71,089,732

G

copine 2

increases expression

corosolic acid results in increased expression of CPNE2 mRNA

NCBI chr19:10,440,245...10,477,783
Ensembl chr19:10,434,277...10,471,820

G

CXXC repeat containing interactor of PDZ3 domain

decreases expression

corosolic acid results in decreased expression of CRIPT mRNA

NCBI chr 6:13,334,978...13,342,934
Ensembl chr 6:7,580,703...7,589,399

G

CREB regulated transcription coactivator 1

increases expression

corosolic acid results in increased expression of CRTC1 mRNA

NCBI chr16:19,022,171...19,080,880
Ensembl chr16:18,988,250...19,043,381

G

cystatin C

increases expression

corosolic acid results in increased expression of CST3 mRNA

NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822

G

cystatin E/M

increases expression

corosolic acid results in increased expression of CST6 mRNA

NCBI chr 1:212,084,676...212,086,384
Ensembl chr 1:202,655,322...202,657,030

G

catenin beta 1

increases degradation

corosolic acid results in increased degradation of CTNNB1 protein

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin L

increases expression

corosolic acid results in increased expression of CTSL mRNA

NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548

G

C-X-C motif chemokine ligand 1

increases expression

corosolic acid results in increased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

multiple interactions

corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA]

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions
increases expression

corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL1 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL1 mRNA]
corosolic acid results in increased expression of CXCL1 mRNA

PMID:26513295 PMID:37939859

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511

G

cytochrome b5 type B

increases expression

corosolic acid results in increased expression of CYB5B mRNA

NCBI chr19:51,972,611...52,006,477
Ensembl chr19:35,062,813...35,098,249

G

cytochrome b-245 beta chain

multiple interactions

corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CYBB protein]; PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CYBB protein]]
corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CYBB mRNA]; corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CYBB protein]

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586

G

cytochrome c-1

decreases expression

corosolic acid results in decreased expression of CYC1 mRNA

NCBI chr 7:109,947,750...109,950,142
Ensembl chr 7:108,067,115...108,069,479

G

cytochrome c, somatic

decreases expression

corosolic acid results in decreased expression of CYCS mRNA

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 27, subfamily b, polypeptide 1

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CYP27B1 mRNA]

NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:62,871,297...62,876,241

G

death associated protein 3

decreases expression

corosolic acid results in decreased expression of DAP3 mRNA

NCBI chr 2:176,617,151...176,645,293
Ensembl chr 2:174,318,983...174,346,461

G

DENN domain containing 4C

increases expression

corosolic acid results in increased expression of DENND4C mRNA

NCBI chr 5:106,316,942...106,421,484
Ensembl chr 5:101,272,005...101,368,118

G

24-dehydrocholesterol reductase

increases expression

corosolic acid results in increased expression of DHCR24 mRNA

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137

G

deoxyhypusine synthase

increases expression

corosolic acid results in increased expression of DHPS mRNA

NCBI chr19:39,987,328...39,991,418
Ensembl chr19:23,082,448...23,086,881

G

dehydrogenase/reductase 3

increases expression

corosolic acid results in increased expression of DHRS3 mRNA

NCBI chr 5:162,031,853...162,065,655
Ensembl chr 5:156,747,962...156,782,417

G

diablo, IAP-binding mitochondrial protein

decreases expression

corosolic acid results in decreased expression of DIABLO mRNA; corosolic acid results in decreased expression of DIABLO protein

PMID:28506699 PMID:37939859

NCBI chr12:38,716,668...38,731,285
Ensembl chr12:33,055,263...33,070,387

G

dickkopf WNT signaling pathway inhibitor 2

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of DKK2 mRNA]

NCBI chr 2:223,242,375...223,334,249
Ensembl chr 2:220,568,338...220,660,225

G

DNA methyltransferase 1-associated protein 1

increases expression

corosolic acid results in increased expression of DMAP1 mRNA

NCBI chr 5:136,380,211...136,388,229
Ensembl chr 5:131,143,729...131,151,742

G

DnaJ heat shock protein family (Hsp40) member B1

decreases expression

corosolic acid results in decreased expression of DNAJB1 mRNA

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member C19

decreases expression

corosolic acid results in decreased expression of DNAJC19 mRNA

NCBI chr 2:118,851,497...118,875,813
Ensembl chr 2:116,923,272...116,945,264

G

DnaJ heat shock protein family (Hsp40) member C7

decreases expression

corosolic acid results in decreased expression of DNAJC7 mRNA

NCBI chr10:86,018,977...86,055,419
Ensembl chr10:85,518,621...85,555,575

G

dynein, axonemal, light chain 1

increases expression

corosolic acid results in increased expression of DNAL1 mRNA

NCBI chr 6:109,478,941...109,515,201
Ensembl chr 6:103,747,753...103,778,878

G

dedicator of cytokinesis 6

increases expression

corosolic acid results in increased expression of DOCK6 mRNA

NCBI chr 8:28,618,523...28,670,741
Ensembl chr 8:20,342,089...20,394,552

G

dedicator of cytokinesis 8

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of DOCK8 mRNA]

NCBI chr 1:232,075,468...232,268,830
Ensembl chr 1:222,649,309...222,842,474

G

dual specificity phosphatase 22

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of DUSP22 gene]

NCBI chr17:33,989,637...34,040,021
Ensembl chr17:33,780,981...33,831,321

G

EDAR associated via death domain

decreases expression

corosolic acid results in decreased expression of EDARADD mRNA

NCBI chr17:92,850,791...92,894,808
Ensembl chr17:85,656,905...85,910,447

G

EGF containing fibulin extracellular matrix protein 1

increases expression

corosolic acid results in increased expression of EFEMP1 mRNA

NCBI chr14:106,811,769...106,890,961
Ensembl chr14:102,610,908...102,690,018

G

eukaryotic translation initiation factor 4A2

increases expression

corosolic acid results in increased expression of EIF4A2 mRNA

NCBI chr11:91,268,730...91,276,738
Ensembl chr11:77,764,124...77,770,781

G

eukaryotic translation initiation factor 4H

decreases expression

corosolic acid results in decreased expression of EIF4H mRNA

NCBI chr12:27,719,527...27,736,350
Ensembl chr12:22,082,835...22,099,876

G

epsin 3

decreases expression

corosolic acid results in decreased expression of EPN3 mRNA

NCBI chr10:79,935,857...79,946,121
Ensembl chr10:79,438,978...79,447,356

G

endoplasmic reticulum oxidoreductase 1 beta

increases expression

corosolic acid results in increased expression of ERO1B mRNA

NCBI chr17:92,913,696...92,987,401
Ensembl chr17:85,929,618...86,003,398

G

exostosin-like glycosyltransferase 3

increases expression

corosolic acid results in increased expression of EXTL3 mRNA

NCBI chr15:43,469,293...43,559,760
Ensembl chr15:39,293,605...39,338,898

G

coagulation factor II, thrombin

increases expression

corosolic acid results in increased expression of F2 mRNA

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486

G

family with sequence similarity 136, member A

decreases expression

corosolic acid results in decreased expression of FAM136A mRNA

NCBI chr 4:120,362,563...120,368,479
Ensembl chr 4:118,805,127...118,811,047

G

family with sequence similarity 162, member A

decreases expression

corosolic acid results in decreased expression of FAM162A mRNA

NCBI chr11:78,186,260...78,215,186
Ensembl chr11:64,680,323...64,711,239

G

family with sequence similarity 168, member B

increases expression

corosolic acid results in increased expression of FAM168B mRNA

NCBI chr 9:44,501,466...44,534,571
Ensembl chr 9:37,006,689...37,033,723

G

FA complementation group I

decreases expression

corosolic acid results in decreased expression of FANCI mRNA

NCBI chr 1:142,736,636...142,792,999
Ensembl chr 1:133,327,297...133,383,640

G

Fas cell surface death receptor

decreases expression

corosolic acid results in decreased expression of FAS mRNA; corosolic acid results in decreased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

fibulin 1

increases expression

corosolic acid results in increased expression of FBLN1 mRNA

NCBI chr 7:118,190,347...118,269,965
Ensembl chr 7:116,310,582...116,390,075

G

F-box and WD repeat domain containing 9

increases expression

corosolic acid results in increased expression of FBXW9 mRNA

NCBI chr19:39,995,408...40,002,312
Ensembl chr19:23,090,534...23,097,439

G

FRY microtubule binding protein

increases expression

corosolic acid results in increased expression of FRY mRNA

NCBI chr12:9,530,360...9,773,391
Ensembl chr12:4,493,891...4,799,116

G

FUN14 domain containing 2

increases expression

corosolic acid results in increased expression of FUNDC2 mRNA

NCBI chr18:142,829...155,123
Ensembl chr18:132,248...138,345

G

GABA type A receptor associated protein like 2

increases expression

corosolic acid results in increased expression of GABARAPL2 mRNA

NCBI chr19:56,819,826...56,830,662
Ensembl chr19:39,910,534...39,924,628

G

GATA binding protein 3

increases expression

corosolic acid results in increased expression of GATA3 mRNA

NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391

G

glutamine amidotransferase class 1 domain containing 1

decreases expression

corosolic acid results in decreased expression of GATD1 mRNA

NCBI chr 1:205,936,189...205,942,121
Ensembl chr 1:196,504,833...196,512,551

G

guanylate binding protein 4

decreases expression

corosolic acid results in decreased expression of GBP4 mRNA

NCBI chr 2:233,978,163...233,992,124
Ensembl chr 2:231,305,244...231,318,879

G

ganglioside-induced differentiation-associated-protein 1

decreases expression

corosolic acid results in decreased expression of GDAP1 mRNA

NCBI chr 5:6,715,935...6,735,013
Ensembl chr 5:1,932,613...2,030,061

G

glycerophosphodiester phosphodiesterase 1

increases expression

corosolic acid results in increased expression of GDE1 mRNA

NCBI chr 1:182,451,182...182,466,569
Ensembl chr 1:172,954,394...173,032,429

G

growth differentiation factor 11

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF11 mRNA]

NCBI chr 7:1,896,229...1,909,147
Ensembl chr 7:1,311,732...1,320,725

G

growth differentiation factor 15

increases expression

corosolic acid results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055

G

glutaminase

decreases expression

corosolic acid results in decreased expression of GLS mRNA

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:49,344,781...49,416,900

G

glutamate-ammonia ligase

decreases expression

corosolic acid results in decreased expression of GLUL mRNA

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108

G

glutamic--pyruvic transaminase 2

increases expression

corosolic acid results in increased expression of GPT2 mRNA

NCBI chr19:37,700,023...37,734,551
Ensembl chr19:21,517,621...21,560,610

G

glutamate ionotropic receptor AMPA type subunit 1

increases expression

corosolic acid results in increased expression of GRIA1 mRNA

NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,210,713...41,527,283

G

gelsolin

increases expression

corosolic acid results in increased expression of GSN mRNA

NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:18,585,172...18,638,402

G

hydroxyacyl-CoA dehydrogenase

decreases expression

corosolic acid results in decreased expression of HADH mRNA

NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:219,787,927...219,830,353

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

decreases expression

corosolic acid results in decreased expression of HADHA mRNA

NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:26,187,956...26,227,869

G

hemoglobin alpha, adult chain 3

increases expression

corosolic acid results in increased expression of HBA2 mRNA

NCBI chr10:15,816,099...15,816,943
Ensembl chr10:15,311,634...15,312,481

G

hemoglobin subunit beta

increases expression

corosolic acid results in increased expression of HBB mRNA

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:158,120,200...158,252,012

G

HEAT repeat containing 5A

increases expression

corosolic acid results in increased expression of HEATR5A mRNA

NCBI chr 6:75,057,226...75,155,207
Ensembl chr 6:69,321,869...69,419,773

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

corosolic acid results in increased expression of HERPUD1 mRNA; corosolic acid results in increased expression of HERPUD1 protein

NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,598,417...10,618,424

G

histidine triad nucleotide binding protein 3

increases expression

corosolic acid results in increased expression of HINT3 mRNA

NCBI chr 1:28,854,860...28,864,723
Ensembl chr 1:27,035,905...27,047,721

G

heme oxygenase 1

increases expression

corosolic acid results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

homeo box C4

increases expression

corosolic acid results in increased expression of HOXC4 mRNA

NCBI chr 7:136,049,059...136,051,601
Ensembl chr 7:134,170,591...134,173,133

G

heparan sulfate-glucosamine 3-sulfotransferase 1

increases expression

corosolic acid results in increased expression of HS3ST1 mRNA

NCBI chr14:75,398,101...75,429,628
Ensembl chr14:71,185,682...71,223,248

G

heat shock protein family A (Hsp70) member 13

increases expression

corosolic acid results in increased expression of HSPA13 mRNA

NCBI chr11:27,862,717...27,876,898
Ensembl chr11:14,373,275...14,389,895

G

heat shock protein family A (Hsp70) member 1B

increases expression

corosolic acid results in increased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family B (small) member 8

increases expression

corosolic acid results in increased expression of HSPB8 mRNA

NCBI chr12:45,835,899...45,866,449
Ensembl chr12:40,176,532...40,191,185

G

heparan sulfate proteoglycan 2

increases expression

corosolic acid results in increased expression of HSPG2 mRNA

NCBI chr 5:154,960,818...155,061,971
Ensembl chr 5:149,677,476...149,778,594

G

HtrA serine peptidase 1

increases expression

corosolic acid results in increased expression of HTRA1 mRNA

NCBI chr 1:194,928,069...194,977,619
Ensembl chr 1:185,497,735...185,547,379

G

huntingtin

increases expression

corosolic acid results in increased expression of HTT mRNA

NCBI chr14:80,070,456...80,219,668
Ensembl chr14:75,845,836...75,995,070

G

intercellular adhesion molecule 1

increases expression

corosolic acid results in increased expression of ICAM1 mRNA

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

isocitrate dehydrogenase (NADP(+)) 2

decreases expression

corosolic acid results in decreased expression of IDH2 mRNA

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025

G

intraflagellar transport 46

increases expression

corosolic acid results in increased expression of IFT46 mRNA

NCBI chr 8:53,975,085...54,000,837
Ensembl chr 8:45,087,440...45,104,052

G

insulin-like growth factor 1 receptor

multiple interactions

corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IGF1R protein]

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor binding protein 6

increases expression

corosolic acid results in increased expression of IGFBP6 mRNA

NCBI chr 7:135,154,919...135,159,550
Ensembl chr 7:133,276,234...133,280,966

G

interleukin 17A

multiple interactions

corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889

G

inositol polyphosphate phosphatase-like 1

increases expression

corosolic acid results in increased expression of INPPL1 mRNA

NCBI chr 1:165,595,047...165,609,503
Ensembl chr 1:156,183,059...156,197,500

G

isochorismatase domain containing 2b

increases expression

corosolic acid results in increased expression of ISOC2 mRNA

NCBI chr 1:78,001,735...78,022,565
Ensembl chr 1:68,972,960...68,993,757

G

integral membrane protein 2B

increases expression

corosolic acid results in increased expression of ITM2B mRNA

NCBI chr15:54,955,549...54,978,455
Ensembl chr15:48,546,001...48,568,917

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of JUN protein]; corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

JunD proto-oncogene, AP-1 transcription factor subunit

increases expression

corosolic acid results in increased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,734,122...18,735,799

G

potassium channel tetramerization domain containing 11

increases expression

corosolic acid results in increased expression of KCTD11 mRNA

NCBI chr10:55,101,292...55,103,455
Ensembl chr10:54,599,754...54,604,760

G

kinesin family member 11

decreases expression

corosolic acid results in decreased expression of KIF11 mRNA; corosolic acid results in decreased expression of KIF11 protein

NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 22

decreases expression

corosolic acid results in decreased expression of KIF22 mRNA; corosolic acid results in decreased expression of KIF22 protein

NCBI chr 1:191,065,875...191,080,955
Ensembl chr 1:181,635,183...181,650,401

G

kinesin family member 4A

decreases expression

corosolic acid results in decreased expression of KIF4A mRNA; corosolic acid results in decreased expression of KIF4A protein

NCBI chr X:69,761,803...69,864,335
Ensembl chr X:65,721,779...65,824,139

G

kininogen 1

increases expression

corosolic acid results in increased expression of KNG1 mRNA

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555

G

keratin 76

increases expression

corosolic acid results in increased expression of KRT76 mRNA

NCBI chr 7:134,895,677...134,904,162
Ensembl chr 7:133,016,992...133,025,496

G

lysosomal-associated membrane protein 2

multiple interactions

corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein]
corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein]]

NCBI chr X:122,038,734...122,087,745
Ensembl chr X:117,057,606...117,260,522

G

lipocalin 2

increases expression

corosolic acid results in increased expression of LCN2 mRNA

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095

G

low density lipoprotein receptor

increases expression

corosolic acid results in increased expression of LDLR mRNA

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580

G

galectin-like

increases expression

corosolic acid results in increased expression of LGALSL mRNA

NCBI chr14:99,198,340...99,205,846
Ensembl chr14:94,996,990...95,004,980

G

lipase E, hormone sensitive type

increases expression

corosolic acid results in increased expression of LIPE mRNA

NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:80,965,627...80,984,310

G

leucine-rich pentatricopeptide repeat containing

decreases expression

corosolic acid results in decreased expression of LRPPRC mRNA

NCBI chr 6:15,612,638...15,695,113
Ensembl chr 6:9,859,867...9,942,293

G

lipolysis stimulated lipoprotein receptor

increases expression

corosolic acid results in increased expression of LSR mRNA

NCBI chr 1:95,313,830...95,329,471
Ensembl chr 1:86,186,431...86,201,952

G

lactotransferrin

increases expression

corosolic acid results in increased expression of LTF mRNA

NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:110,999,948...111,022,795

G

lumican

increases expression

corosolic acid results in increased expression of LUM mRNA

NCBI chr 7:34,245,323...34,252,510
Ensembl chr 7:32,358,614...32,365,793

G

lymphocyte antigen 6 family member D

decreases expression

corosolic acid results in decreased expression of LY6D mRNA

NCBI chr 7:108,532,207...108,533,943
Ensembl chr 7:106,643,232...106,644,733

G

leucine zipper transcription factor-like 1

increases expression

corosolic acid results in increased expression of LZTFL1 mRNA

NCBI chr 8:132,222,339...132,237,757
Ensembl chr 8:123,344,925...123,360,192

G

MAP-kinase activating death domain

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of MADD gene]

NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:77,114,314...77,157,701

G

mannosidase, alpha, class 2A, member 1

increases expression

corosolic acid results in increased expression of MAN2A1 mRNA

NCBI chr 9:111,698,913...111,855,257
Ensembl chr 9:104,252,001...104,408,349

G

mitogen activated protein kinase 1

increases phosphorylation

corosolic acid results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

corosolic acid results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

magnesium-dependent phosphatase 1

decreases expression

corosolic acid results in decreased expression of MDP1 mRNA

NCBI chr15:33,118,944...33,121,817
Ensembl chr15:29,148,994...29,151,905

G

mediator complex subunit 18

increases expression

corosolic acid results in increased expression of MED18 mRNA

NCBI chr 5:149,947,345...149,952,672
Ensembl chr 5:144,663,252...144,668,635

G

matrix Gla protein

increases expression

corosolic acid results in increased expression of MGP mRNA

NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:169,766,279...169,769,667

G

misshapen-like kinase 1

decreases expression

corosolic acid results in decreased expression of MINK1 mRNA

NCBI chr10:55,776,879...55,829,406
Ensembl chr10:55,278,391...55,330,782

G

mitochondrial intermediate peptidase

decreases expression

corosolic acid results in decreased expression of MIPEP mRNA

NCBI chr15:39,102,301...39,227,915
Ensembl chr15:34,926,207...35,051,727

G

matrix metallopeptidase 1

increases expression

corosolic acid results in increased expression of MMP1 mRNA

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 13

increases expression

corosolic acid results in increased expression of MMP13 mRNA

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

increases expression
decreases expression

corosolic acid results in increased expression of MMP2 mRNA
corosolic acid results in decreased expression of MMP2 mRNA; corosolic acid results in decreased expression of MMP2 protein

PMID:37860891 PMID:37939859

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
multiple interactions

corosolic acid results in decreased expression of MMP9 protein
corosolic acid binds to and results in decreased expression of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

mitochondrial pyruvate carrier 2

decreases expression

corosolic acid results in decreased expression of MPC2 mRNA

NCBI chr13:80,261,143...80,280,668
Ensembl chr13:77,728,250...77,747,664

G

major histocompatibility complex, class I-related

increases expression

corosolic acid results in increased expression of MR1 mRNA

NCBI chr13:69,850,420...69,868,302
Ensembl chr13:67,299,585...67,317,970

G

mannose receptor, C type 1

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA]

NCBI chr17:82,157,725...82,239,411
Ensembl chr17:77,249,187...77,330,857

G

mitochondrial ribosomal protein L16

decreases expression

corosolic acid results in decreased expression of MRPL16 mRNA

NCBI chr 1:218,058,439...218,063,251
Ensembl chr 1:208,633,586...208,640,667

G

mitochondrial ribosomal protein L19

decreases expression

corosolic acid results in decreased expression of MRPL19 mRNA

NCBI chr 4:116,079,654...116,083,883
Ensembl chr 4:114,521,824...114,526,053

G

mitochondrial ribosomal protein L20

decreases expression

corosolic acid results in decreased expression of MRPL20 mRNA

NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:166,408,962...166,413,492

G

mitochondrial ribosomal protein L24

decreases expression

corosolic acid results in decreased expression of MRPL24 mRNA

NCBI chr 2:175,680,872...175,687,107
Ensembl chr 2:173,383,224...173,389,248

G

mitochondrial ribosomal protein L34

decreases expression

corosolic acid results in decreased expression of MRPL34 mRNA

NCBI chr16:18,186,447...18,187,182
Ensembl chr16:18,151,342...18,153,208

G

mitochondrial ribosomal protein L37

decreases expression

corosolic acid results in decreased expression of MRPL37 mRNA

NCBI chr 5:127,056,679...127,075,000
Ensembl chr 5:121,829,111...121,846,176

G

mitochondrial ribosomal protein L38

decreases expression

corosolic acid results in decreased expression of MRPL38 mRNA

NCBI chr10:101,864,242...101,871,048
Ensembl chr10:101,365,353...101,372,171

G

mitochondrial ribosomal protein L41

decreases expression

corosolic acid results in decreased expression of MRPL41 mRNA

NCBI chr 3:28,178,837...28,179,755
Ensembl chr 3:7,779,143...7,782,818

G

mitochondrial ribosomal protein L47

decreases expression

corosolic acid results in decreased expression of MRPL47 mRNA

NCBI chr 2:117,436,199...117,447,790
Ensembl chr 2:115,500,264...115,518,994

G

mitochondrial ribosomal protein L53

decreases expression

corosolic acid results in decreased expression of MRPL53 mRNA

NCBI chr 4:117,173,043...117,173,933

G

mitochondrial ribosomal protein L57

decreases expression

corosolic acid results in decreased expression of MRPL57 mRNA

NCBI chr15:36,086,457...36,087,319
Ensembl chr15:31,970,860...31,973,993

G

mitochondrial ribosomal protein S11

decreases expression

corosolic acid results in decreased expression of MRPS11 mRNA

NCBI chr 1:142,117,045...142,126,644
Ensembl chr 1:132,680,420...132,717,253

G

mitochondrial ribosomal protein S33

decreases expression

corosolic acid results in decreased expression of MRPS33 mRNA

NCBI chr 4:69,563,501...69,572,317
Ensembl chr 4:68,596,729...68,605,428

G

mitochondrial ribosomal protein S34

decreases expression

corosolic acid results in decreased expression of MRPS34 mRNA

NCBI chr10:14,420,543...14,421,674
Ensembl chr10:13,916,026...13,918,406

G

mitochondrial ribosomal protein S6

decreases expression

corosolic acid results in decreased expression of MRPS6 mRNA

NCBI chr11:44,778,667...44,834,420
Ensembl chr11:31,295,614...31,348,484

G

mitochondrial ribosome recycling factor

decreases expression

corosolic acid results in decreased expression of MRRF mRNA

NCBI chr 3:39,884,530...39,941,317
Ensembl chr 3:19,487,182...19,543,908

G

MSL complex subunit 1

increases expression

corosolic acid results in increased expression of MSL1 mRNA

NCBI chr10:84,251,362...84,263,384
Ensembl chr10:83,755,720...83,765,726

G

methylsterol monooxygenase 1

increases expression

corosolic acid results in increased expression of MSMO1 mRNA

NCBI chr16:29,747,113...29,764,360
Ensembl chr16:24,980,697...24,998,016

G

mitochondrially encoded ATP synthase membrane subunit 6

multiple interactions

corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of ATP6 mRNA]

NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599

G

metallothionein 1, pseudogene 3

increases expression

corosolic acid results in increased expression of MT1E mRNA

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2

decreases expression

corosolic acid results in decreased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784

G

mitochondrial amidoxime reducing component 2

decreases expression

corosolic acid results in decreased expression of MTARC2 mRNA

NCBI chr13:98,894,347...98,928,754

G

mitochondrial carrier 1

decreases expression

corosolic acid results in decreased expression of MTCH1 mRNA

NCBI chr20:7,391,558...7,415,291
Ensembl chr20:7,389,949...7,413,426

G

mitochondrial carrier 2

decreases expression

corosolic acid results in decreased expression of MTCH2 mRNA

NCBI chr 3:97,286,388...97,306,028
Ensembl chr 3:76,830,413...76,850,189

G

mitochondrial fission regulator 1

decreases expression

corosolic acid results in decreased expression of MTFR1 mRNA

NCBI chr 2:103,594,458...103,629,697
Ensembl chr 2:101,679,265...101,713,544

G

mitochondrial ribosome-associated GTPase 2

decreases expression

corosolic acid results in decreased expression of MTG2 mRNA

NCBI chr 3:187,543,166...187,558,973
Ensembl chr 3:167,165,982...167,181,358

G

methylenetetrahydrofolate reductase

decreases expression

corosolic acid results in decreased expression of MTHFR mRNA

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797

G

mechanistic target of rapamycin kinase

multiple interactions

corosolic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

NBR1, autophagy cargo receptor

increases expression

corosolic acid results in increased expression of NBR1 mRNA; corosolic acid results in increased expression of NBR1 protein

NCBI chr10:86,978,024...87,006,664
Ensembl chr10:86,478,290...86,506,412

G

neural cell adhesion molecule 1

increases expression

corosolic acid results in increased expression of NCAM1 mRNA

NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:49,865,633...50,166,014

G

nuclear receptor coactivator 4

increases expression

corosolic acid results in increased expression of NCOA4 mRNA

NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641

G

NADH:ubiquinone oxidoreductase subunit A2

decreases expression

corosolic acid results in decreased expression of NDUFA2 mRNA

NCBI chr18:28,629,795...28,631,884
Ensembl chr18:28,355,774...28,358,076

G

NADH:ubiquinone oxidoreductase subunit A3

decreases expression

corosolic acid results in decreased expression of NDUFA3 mRNA

NCBI chr 1:74,512,928...74,515,558
Ensembl chr 1:65,597,578...65,600,235

G

Ndufa4, mitochondrial complex associated

decreases expression

corosolic acid results in decreased expression of NDUFA4 mRNA

NCBI chr 4:40,968,391...40,975,559
Ensembl chr 4:40,002,216...40,023,920

G

NADH:ubiquinone oxidoreductase subunit A5

decreases expression

corosolic acid results in decreased expression of NDUFA5 mRNA

NCBI chr 4:53,962,877...53,971,235
Ensembl chr 4:52,995,546...53,005,598
Ensembl chr 5:52,995,546...53,005,598

G

NADH:ubiquinone oxidoreductase subunit A8

decreases expression

corosolic acid results in decreased expression of NDUFA8 mRNA

NCBI chr 3:39,783,479...39,799,507
Ensembl chr 3:19,386,065...19,402,071

G

NADH:ubiquinone oxidoreductase subunit AB1

decreases expression

corosolic acid results in decreased expression of NDUFAB1 mRNA

NCBI chr 1:186,075,933...186,091,843
Ensembl chr 1:176,644,703...176,658,099

G

NADH:ubiquinone oxidoreductase subunit B1

decreases expression

corosolic acid results in decreased expression of NDUFB1 mRNA

NCBI chr 6:126,880,537...126,888,935

G

NADH:ubiquinone oxidoreductase subunit B10

decreases expression

corosolic acid results in decreased expression of NDUFB10 mRNA

NCBI chr10:14,253,805...14,255,966
Ensembl chr10:13,749,275...13,751,442

G

NADH:ubiquinone oxidoreductase subunit B3

decreases expression

corosolic acid results in decreased expression of NDUFB3 mRNA

NCBI chr 9:67,623,417...67,633,629
Ensembl chr 9:60,129,154...60,139,446

G

NADH:ubiquinone oxidoreductase subunit B5

decreases expression

corosolic acid results in decreased expression of NDUFB5 mRNA

NCBI chr 2:117,447,605...117,461,943
Ensembl chr 2:115,519,154...115,533,589

G

NADH:ubiquinone oxidoreductase subunit B7

decreases expression

corosolic acid results in decreased expression of NDUFB7 mRNA

NCBI chr19:41,472,953...41,477,291
Ensembl chr19:24,568,241...24,572,579

G

NADH:ubiquinone oxidoreductase subunit C1

decreases expression

corosolic acid results in decreased expression of NDUFC1 mRNA

NCBI chr 2:137,597,944...137,601,819
Ensembl chr 2:135,447,119...135,450,874

G

NADH:ubiquinone oxidoreductase subunit C2

decreases expression

corosolic acid results in decreased expression of NDUFC2 mRNA

NCBI chr 1:161,122,370...161,129,413
Ensembl chr 1:151,711,901...151,718,189

G

NADH:ubiquinone oxidoreductase core subunit S3

decreases expression

corosolic acid results in decreased expression of NDUFS3 mRNA

NCBI chr 3:97,332,477...97,339,654
Ensembl chr 3:76,876,646...76,883,824

G

NADH:ubiquinone oxidoreductase subunit S4

decreases expression

corosolic acid results in decreased expression of NDUFS4 mRNA

NCBI chr 2:47,684,420...47,794,914
Ensembl chr 2:45,951,313...46,061,846

G

NADH:ubiquinone oxidoreductase subunit S6

decreases expression

corosolic acid results in decreased expression of NDUFS6 mRNA

NCBI chr 1:31,797,400...31,805,965
Ensembl chr 1:29,968,842...29,977,467

G

NADH:ubiquinone oxidoreductase core subunit S7

decreases expression

corosolic acid results in decreased expression of NDUFS7 mRNA

NCBI chr 7:10,103,226...10,110,862
Ensembl chr 7:9,450,392...9,460,195

G

NADH:ubiquinone oxidoreductase subunit V3

decreases expression

corosolic acid results in decreased expression of NDUFV3 mRNA

NCBI chr20:9,613,786...9,622,941
Ensembl chr20:9,612,431...9,623,074
Ensembl chr13:9,612,431...9,623,074

G

NFKB inhibitor alpha

increases expression
multiple interactions

corosolic acid results in increased expression of NFKBIA mRNA
corosolic acid results in increased expression of and results in decreased phosphorylation of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

NFU1 iron-sulfur cluster scaffold

decreases expression

corosolic acid results in decreased expression of NFU1 mRNA

NCBI chr 4:121,016,316...121,036,925
Ensembl chr 4:119,459,061...119,480,373

G

nitric oxide synthase 2

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

NADPH oxidase 4

multiple interactions

corosolic acid inhibits the reaction [Doxorubicin results in increased expression of NOX4 mRNA]

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406

G

nuclear receptor binding SET domain protein 3

decreases expression

corosolic acid results in decreased expression of NSD3 mRNA

NCBI chr16:73,056,748...73,170,082
Ensembl chr16:66,358,973...66,465,423

G

neuronal vesicle trafficking associated 2

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of NSG2 gene]

NCBI chr10:16,106,073...16,165,915
Ensembl chr10:15,601,596...15,661,441

G

nucleoside-triphosphatase, cancer-related

increases expression

corosolic acid results in increased expression of NTPCR mRNA

NCBI chr19:70,598,816...70,612,580
Ensembl chr19:53,695,976...53,715,202

G

OCIA domain containing 1

decreases expression

corosolic acid results in decreased expression of OCIAD1 mRNA

NCBI chr14:35,251,891...35,269,440
Ensembl chr14:34,897,847...34,915,286

G

olfactomedin-like 3

increases expression

corosolic acid results in increased expression of OLFML3 mRNA

NCBI chr 2:193,932,665...193,935,494
Ensembl chr 2:191,244,221...191,247,050

G

outer mitochondrial membrane lipid metabolism regulator OPA3

decreases expression

corosolic acid results in decreased expression of OPA3 mRNA

NCBI chr 1:88,007,707...88,037,639
Ensembl chr 1:78,880,114...78,901,469
Ensembl chr 1:78,880,114...78,901,469

G

ORAI calcium release-activated calcium modulator 1

multiple interactions

corosolic acid inhibits the reaction [Ethanol results in increased expression of ORAI1 protein]

NCBI chr12:39,195,139...39,209,030
Ensembl chr12:33,534,344...33,548,405

G

OXA1L, mitochondrial inner membrane protein

decreases expression

corosolic acid results in decreased expression of OXA1L mRNA

NCBI chr15:31,783,725...31,791,353
Ensembl chr15:27,813,625...27,821,319

G

peptidyl arginine deiminase 1

increases expression

corosolic acid results in increased expression of PADI1 mRNA

NCBI chr 5:158,402,614...158,435,077
Ensembl chr 5:153,119,566...153,152,034

G

PATJ, crumbs cell polarity complex component

increases expression

corosolic acid results in increased expression of PATJ mRNA

NCBI chr 5:118,177,557...118,480,301
Ensembl chr 5:113,062,118...113,364,807

G

PBX homeobox interacting protein 1

increases expression

corosolic acid results in increased expression of PBXIP1 mRNA

NCBI chr 2:177,154,056...177,167,810
Ensembl chr 2:174,856,397...174,868,919

G

piccolo (presynaptic cytomatrix protein)

increases expression

corosolic acid results in increased expression of PCLO mRNA

NCBI chr 4:20,646,604...21,005,171
Ensembl chr 4:19,695,315...20,049,885

G

proprotein convertase subtilisin/kexin type 1 inhibitor

increases expression

corosolic acid results in increased expression of PCSK1N mRNA

NCBI chr X:17,251,963...17,255,405
Ensembl chr X:14,580,038...14,583,566

G

programmed cell death 4

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PDCD4 protein]

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275

G

pyruvate dehydrogenase kinase 4

multiple interactions

corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of PDK4 mRNA]

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:33,589,799...33,601,850

G

PIGB opposite strand 1

decreases expression

corosolic acid results in decreased expression of PIGBOS1 mRNA

NCBI chr 8:73,775,732...73,780,102
Ensembl chr 8:73,775,732...73,780,102

G

phosphatidylinositol glycan anchor biosynthesis, class U

decreases expression

corosolic acid results in decreased expression of PIGU mRNA

NCBI chr 3:164,245,011...164,341,444
Ensembl chr 3:143,784,832...143,880,807

G

plasminogen activator, tissue type

increases expression

corosolic acid results in increased expression of PLAT mRNA

NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223

G

plasminogen activator, urokinase

increases expression

corosolic acid results in increased expression of PLAU mRNA

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775

G

plasminogen activator, urokinase receptor

increases expression

corosolic acid results in increased expression of PLAUR mRNA

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595

G

pleckstrin homology domain containing B2

increases expression

corosolic acid results in increased expression of PLEKHB2 mRNA

NCBI chr 9:44,545,473...44,578,122
Ensembl chr 9:37,038,751...37,082,231

G

plasminogen

increases expression

corosolic acid results in increased expression of PLG mRNA

NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:48,325,185...48,367,786

G

perilipin 4

decreases expression

corosolic acid results in decreased expression of PLIN4 mRNA

NCBI chr 9:1,016,334...1,025,249
Ensembl chr 9:929,176...938,056

G

polo-like kinase 1

decreases expression

corosolic acid results in decreased expression of PLK1 mRNA

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:176,716,420...176,726,400

G

peptidase, mitochondrial processing subunit beta

decreases expression

corosolic acid results in decreased expression of PMPCB mRNA

NCBI chr 4:14,189,807...14,202,584
Ensembl chr 4:13,297,559...13,310,367

G

patatin-like phospholipase domain containing 2

increases expression

corosolic acid results in increased expression of PNPLA2 mRNA

NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:196,552,723...196,557,805

G

RNA polymerase II, I and III subunit K

decreases expression

corosolic acid results in decreased expression of POLR2K mRNA

NCBI chr 7:69,241,233...69,244,579
Ensembl chr 7:67,356,113...67,357,668

G

periostin

increases expression

corosolic acid results in increased expression of POSTN mRNA

NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:138,527,696...138,559,099

G

peptidylprolyl isomerase F

decreases expression

corosolic acid results in decreased expression of PPIF mRNA

NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,257,106...1,263,913

G

PRELI domain containing 3B

increases expression

corosolic acid results in increased expression of PRELID3B mRNA

NCBI chr 3:163,263,059...163,271,055
Ensembl chr 3:163,262,985...163,271,181

G

DNA primase subunit 1

decreases expression

corosolic acid results in decreased expression of PRIM1 mRNA

NCBI chr 7:1,031,436...1,047,134
Ensembl chr 7:431,805...462,526

G

protein kinase AMP-activated catalytic subunit alpha 2

decreases response to substance
multiple interactions

PRKAA2 gene mutant form results in decreased susceptibility to corosolic acid
PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of CYBB protein]]

NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543

G

protein only RNase P catalytic subunit

decreases expression

corosolic acid results in decreased expression of PRORP mRNA

NCBI chr 6:78,404,821...78,497,562
Ensembl chr 6:72,670,847...72,762,416

G

pleckstrin and Sec7 domain containing 4

increases expression

corosolic acid results in increased expression of PSD4 mRNA

NCBI chr 3:27,535,341...27,571,850
Ensembl chr 3:7,137,155...7,173,571

G

phosphoserine phosphatase

increases expression

corosolic acid results in increased expression of PSPH mRNA

NCBI chr12:32,527,091...32,541,182
Ensembl chr12:26,883,133...26,905,074

G

pentatricopeptide repeat domain 1

decreases expression

corosolic acid results in decreased expression of ATP5MF-PTCD1 mRNA

NCBI chr12:14,559,419...14,577,198
Ensembl chr12:9,445,714...9,463,508

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
corosolic acid results in increased expression of PTGS2 mRNA; corosolic acid results in increased expression of PTGS2 protein

PMID:26513295 PMID:37939859

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

pentraxin 3

increases expression

corosolic acid results in increased expression of PTX3 mRNA

NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:150,487,513...150,493,323

G

glycogen phosphorylase, muscle associated

increases expression

corosolic acid results in increased expression of PYGM mRNA

NCBI chr 1:213,119,805...213,134,622
Ensembl chr 1:203,690,533...203,705,368

G

quiescin sulfhydryl oxidase 1

increases expression

corosolic acid results in increased expression of QSOX1 mRNA

NCBI chr13:70,500,060...70,537,711
Ensembl chr13:67,949,780...67,987,459

G

Rab acceptor 1

increases expression

corosolic acid results in increased expression of RABAC1 mRNA

NCBI chr 1:89,691,884...89,695,017
Ensembl chr 1:80,564,033...80,567,163

G

Ras association domain family member 2

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased methylation of RASSF2 gene]

NCBI chr 3:139,697,187...139,733,402
Ensembl chr 3:119,245,821...119,280,431

G

ribonucleoprotein, PTB-binding 2

decreases expression

corosolic acid results in decreased expression of RAVER2 mRNA

NCBI chr 5:115,700,985...115,780,465
Ensembl chr 5:115,701,326...115,778,792

G

retinol binding protein 4

increases expression

corosolic acid results in increased expression of RBP4 mRNA

NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399

G

RELA proto-oncogene, NF-kB subunit

decreases expression
multiple interactions

corosolic acid results in decreased expression of RELA mRNA
corosolic acid results in decreased expression of and affects the localization of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

rhomboid domain containing 2

increases expression

corosolic acid results in increased expression of RHBDD2 mRNA

NCBI chr12:26,680,206...26,690,926
Ensembl chr12:21,043,608...21,054,289

G

ras homolog family member B

increases expression

corosolic acid results in increased expression of RHOB mRNA

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:31,363,548...31,366,108

G

Rho-related BTB domain containing 3

increases expression

corosolic acid results in increased expression of RHOBTB3 mRNA

NCBI chr 2:7,094,972...7,201,507
Ensembl chr 2:5,363,388...5,419,041

G

replication timing regulatory factor 1

decreases expression

corosolic acid results in decreased expression of RIF1 mRNA

NCBI chr 3:56,963,840...57,017,106
Ensembl chr 3:36,554,697...36,603,617

G

RIO kinase 1

increases expression

corosolic acid results in increased expression of RIOK1 mRNA

NCBI chr17:26,972,490...26,995,382
Ensembl chr17:26,766,947...26,789,900

G

RIO kinase 3

increases expression

corosolic acid results in increased expression of RIOK3 mRNA

NCBI chr18:3,602,535...3,628,108
Ensembl chr18:3,327,776...3,353,343

G

Rho family GTPase 3

increases expression

corosolic acid results in increased expression of RND3 mRNA

NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:35,571,143...35,589,327

G

ring finger protein 149

increases expression

corosolic acid results in increased expression of RNF149 mRNA

NCBI chr 9:49,322,524...49,350,361
Ensembl chr 9:41,830,233...41,854,279

G

ring finger protein 167

decreases expression

corosolic acid results in decreased expression of RNF167 mRNA

NCBI chr10:55,859,254...55,863,546
Ensembl chr10:55,360,543...55,364,927

G

ring finger protein 223

increases expression

corosolic acid results in increased expression of RNF223 mRNA

NCBI chr 5:172,005,566...172,008,456
Ensembl chr 5:166,724,984...166,725,751

G

rogdi atypical leucine zipper

increases expression

corosolic acid results in increased expression of ROGDI mRNA

NCBI chr10:11,074,288...11,078,907
Ensembl chr10:10,567,834...10,572,452

G

ribosomal protein L24

decreases expression

corosolic acid results in decreased expression of RPL24 mRNA

NCBI chr11:58,122,997...58,128,405
Ensembl chr11:44,653,937...44,659,370

G

ribosomal protein L34

decreases expression

corosolic acid results in decreased expression of RPL34 mRNA

NCBI chr 2:221,958,551...221,962,309
Ensembl chr 2:219,284,382...219,288,111
Ensembl chr17:219,284,382...219,288,111

G

ribosomal protein L4

decreases expression

corosolic acid results in decreased expression of RPL4 mRNA

NCBI chr 8:73,566,477...73,571,600
Ensembl chr 8:64,671,160...64,676,306

G

ribosomal protein S6

decreases expression

corosolic acid results in decreased expression of RPS6 mRNA

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ras responsive element binding protein 1

increases expression

corosolic acid results in increased expression of RREB1 mRNA

NCBI chr17:27,082,217...27,208,061
Ensembl chr17:26,876,697...27,002,615

G

ribonucleotide reductase catalytic subunit M1

decreases expression

corosolic acid results in decreased expression of RRM1 mRNA; corosolic acid results in decreased expression of RRM1 protein

NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

decreases expression

corosolic acid results in decreased expression of RRM2 mRNA; corosolic acid results in decreased expression of RRM2 protein

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773

G

RT1 class Ia, locus A2

increases expression

corosolic acid results in increased expression of HLA-E mRNA

NCBI chr20:4,872,720...4,876,425

G

reticulon 4

decreases expression

corosolic acid results in decreased expression of RTN4 mRNA

NCBI chr14:107,651,001...107,698,610
Ensembl chr14:103,449,930...103,497,686

G

reticulon 4 interacting protein 1

decreases expression

corosolic acid results in decreased expression of RTN4IP1 mRNA

NCBI chr20:48,964,903...49,004,235
Ensembl chr20:47,382,234...47,422,338

G

store-operated calcium entry-associated regulatory factor

increases expression

corosolic acid results in increased expression of SARAF mRNA

NCBI chr16:64,720,404...64,738,653
Ensembl chr16:58,017,231...58,035,545

G

SET binding factor 1

increases expression

corosolic acid results in increased expression of SBF1 mRNA

NCBI chr 7:122,237,968...122,264,591
Ensembl chr 7:120,358,338...120,384,902

G

scavenger receptor class B, member 2

increases expression

corosolic acid results in increased expression of SCARB2 mRNA

NCBI chr14:15,842,583...15,894,123
Ensembl chr14:15,558,236...15,609,813

G

stearoyl-CoA desaturase

increases expression

corosolic acid results in increased expression of SCD mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

syndecan binding protein 2

increases expression

corosolic acid results in increased expression of SDCBP2 mRNA

NCBI chr 3:160,521,309...160,558,452
Ensembl chr 3:140,070,540...140,098,057

G

succinate dehydrogenase complex assembly factor 3

decreases expression

corosolic acid results in decreased expression of SDHAF3 mRNA

NCBI chr 4:36,066,963...36,127,168
Ensembl chr 4:35,100,506...35,160,749

G

succinate dehydrogenase complex subunit C

decreases expression

corosolic acid results in decreased expression of SDHC mRNA

NCBI chr13:86,077,133...86,098,025
Ensembl chr13:83,544,652...83,566,253

G

semaphorin 3A

increases expression

corosolic acid results in increased expression of SEMA3A mRNA

NCBI chr 4:22,239,418...22,709,907
Ensembl chr 4:21,287,982...21,494,432

G

serine incorporator 1

increases expression

corosolic acid results in increased expression of SERINC1 mRNA

NCBI chr20:37,396,497...37,415,433
Ensembl chr20:36,850,076...36,896,691

G

serpin family E member 1

increases expression

corosolic acid results in increased expression of SERPINE1 mRNA

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657

G

serpin family F member 1

increases expression

corosolic acid results in increased expression of SERPINF1 mRNA

NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646

G

small glutamine rich tetratricopeptide repeat co-chaperone alpha

decreases expression

corosolic acid results in decreased expression of SGTA mRNA

NCBI chr 7:9,304,381...9,321,157
Ensembl chr 7:8,653,778...8,670,458

G

SH3 binding domain protein 5 like

increases expression

corosolic acid results in increased expression of SH3BP5L mRNA

NCBI chr10:42,512,437...42,529,564
Ensembl chr10:42,512,552...42,530,221

G

stem-loop histone mRNA binding protein

decreases expression

corosolic acid results in decreased expression of SLBP mRNA

NCBI chr14:81,295,479...81,306,446
Ensembl chr14:77,071,632...77,081,906

G

solute carrier family 1 member 5

increases expression

corosolic acid results in increased expression of SLC1A5 mRNA

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 25 member 11

decreases expression

corosolic acid results in decreased expression of SLC25A11 mRNA

NCBI chr10:55,856,209...55,859,060
Ensembl chr10:55,357,597...55,360,410

G

solute carrier family 25 member 3

decreases expression

corosolic acid results in decreased expression of SLC25A3 mRNA

NCBI chr 7:27,499,164...27,506,685
Ensembl chr 7:25,586,725...25,667,727

G

solute carrier family 25 member 5

decreases expression

corosolic acid results in decreased expression of SLC25A5 mRNA

NCBI chr X:120,897,616...120,900,683
Ensembl chr X:116,031,803...116,034,967

G

solute carrier family 2 member 1

multiple interactions

corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of SLC2A1 mRNA]

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 4

multiple interactions

corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of SLC2A4 mRNA]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 35, member A4

decreases expression

corosolic acid results in decreased expression of SLC35A4 mRNA

NCBI chr18:28,555,471...28,558,639
Ensembl chr18:28,279,750...28,284,725

G

solute carrier family 38, member 1

increases expression

corosolic acid results in increased expression of SLC38A1 mRNA

NCBI chr 7:129,612,414...129,681,727
Ensembl chr 7:127,738,226...127,802,218

G

solute carrier family 38, member 2

increases expression

corosolic acid results in increased expression of SLC38A2 mRNA

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 7 member 11

increases expression

corosolic acid results in increased expression of SLC7A11 mRNA; corosolic acid results in increased expression of SLC7A11 protein

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536

G

secretory leukocyte peptidase inhibitor

increases expression

corosolic acid results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453

G

SMAD family member 3

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene]

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960

G

SMG9 nonsense mediated mRNA decay factor

increases expression

corosolic acid results in increased expression of SMG9 mRNA

NCBI chr 1:89,116,459...89,139,182
Ensembl chr 1:79,988,612...80,011,254

G

small nuclear ribonucleoprotein polypeptide F

increases expression

corosolic acid results in increased expression of SNRPF mRNA

NCBI chr 7:30,017,460...30,024,162
Ensembl chr 7:28,130,427...28,137,129

G

superoxide dismutase 2

increases expression

corosolic acid results in increased expression of SOD2 mRNA; corosolic acid results in increased expression of SOD2 protein

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

sperm autoantigenic protein 17

decreases expression

corosolic acid results in decreased expression of SPA17 mRNA

NCBI chr 8:45,496,175...45,507,262
Ensembl chr 8:37,307,557...37,318,639

G

spartin

decreases expression

corosolic acid results in decreased expression of SPART mRNA

NCBI chr 2:141,442,770...141,469,388
Ensembl chr 2:139,292,355...139,319,248

G

SPC25 component of NDC80 kinetochore complex

decreases expression

corosolic acid results in decreased expression of SPC25 mRNA

NCBI chr 3:74,337,872...74,396,825
Ensembl chr 3:53,975,704...53,988,959

G

serine peptidase inhibitor, Kunitz type, 2

increases expression

corosolic acid results in increased expression of SPINT2 mRNA

NCBI chr 1:93,685,637...93,708,091
Ensembl chr 1:84,558,166...84,580,616

G

small proline rich protein 2A

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPRR2H mRNA]

NCBI chr 2:180,511,568...180,511,840
Ensembl chr 2:177,815,964...177,816,236

G

squalene epoxidase

increases expression

corosolic acid results in increased expression of SQLE mRNA

NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:90,868,011...90,883,618

G

sequestosome 1

multiple interactions
increases expression

corosolic acid inhibits the reaction [Doxorubicin results in increased expression of SQSTM1 protein]
corosolic acid inhibits the reaction [Doxorubicin results in increased expression of SQSTM1 protein]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of SQSTM1 protein]]
corosolic acid results in increased expression of SQSTM1 mRNA; corosolic acid results in increased expression of SQSTM1 protein

PMID:34296331 PMID:37939859

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein]

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

G

single stranded DNA binding protein 1

decreases expression

corosolic acid results in decreased expression of SSBP1 mRNA

NCBI chr 4:70,232,740...70,242,824
Ensembl chr 4:69,266,102...69,276,135

G

signal transducer and activator of transcription 3

multiple interactions

corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

stromal interaction molecule 1

multiple interactions

corosolic acid inhibits the reaction [Ethanol results in increased expression of STIM1 protein]

NCBI chr 1:166,067,450...166,230,733
Ensembl chr 1:156,656,013...156,818,363

G

serine/threonine kinase 11

multiple interactions

corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]

NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315

G

stonin 2

increases expression

corosolic acid results in increased expression of STON2 mRNA

NCBI chr 6:116,291,898...116,441,391
Ensembl chr 6:110,567,485...110,676,376

G

syntaxin 3

increases expression

corosolic acid results in increased expression of STX3 mRNA

NCBI chr 1:217,940,697...218,114,865
Ensembl chr 1:208,639,115...208,685,805

G

syntaxin 6

increases expression

corosolic acid results in increased expression of STX6 mRNA

NCBI chr13:69,882,647...69,928,895
Ensembl chr13:67,332,314...67,378,576

G

syntaxin 8

decreases expression

corosolic acid results in decreased expression of STX8 mRNA

NCBI chr10:53,154,572...53,393,912
Ensembl chr10:52,654,990...52,894,993

G

SDS3 homolog, SIN3A corepressor complex component

decreases expression

corosolic acid results in decreased expression of SUDS3 mRNA

NCBI chr12:45,137,964...45,160,413
Ensembl chr12:39,477,568...39,499,628

G

surfeit 2

increases expression

corosolic acid results in increased expression of SURF2 mRNA

NCBI chr 3:30,642,735...30,648,525
Ensembl chr 3:10,244,654...10,250,077

G

transforming, acidic coiled-coil containing protein 3

decreases expression

corosolic acid results in decreased expression of TACC3 mRNA

NCBI chr14:81,275,755...81,289,894
Ensembl chr14:77,051,215...77,065,219

G

taspase 1

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of TASP1 gene]

NCBI chr 3:147,630,092...147,861,710
Ensembl chr 3:127,176,692...127,399,600

G

Tax1 binding protein 1

increases expression

corosolic acid results in increased expression of TAX1BP1 mRNA; corosolic acid results in increased expression of TAX1BP1 protein

NCBI chr 4:83,152,549...83,208,463
Ensembl chr 4:81,821,989...81,879,100

G

TATA-box binding protein like 1

decreases expression

corosolic acid results in decreased expression of TBPL1 mRNA

NCBI chr 1:24,597,028...24,622,445
Ensembl chr 1:22,778,459...22,803,122
Ensembl chr 1:22,778,459...22,803,122

G

transforming growth factor beta regulator 4

decreases expression

corosolic acid results in decreased expression of TBRG4 mRNA

NCBI chr14:85,696,738...85,704,691
Ensembl chr14:81,481,981...81,490,756

G

transferrin

increases expression

corosolic acid results in increased expression of TF mRNA

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511

G

transcription factor A, mitochondrial

decreases expression

corosolic acid results in decreased expression of TFAM mRNA

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292

G

transcription factor EB

increases response to substance
multiple interactions

TFEB protein results in increased susceptibility to corosolic acid
TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of SQSTM1 protein]]

NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:13,198,891...13,254,714

G

THAP domain containing 11

decreases expression

corosolic acid results in decreased expression of THAP11 mRNA

NCBI chr19:50,656,839...50,658,656
Ensembl chr19:33,746,854...33,749,540

G

translocase of inner mitochondrial membrane 13

decreases expression

corosolic acid results in decreased expression of TIMM13 mRNA

NCBI chr 7:9,459,490...9,460,849
Ensembl chr 7:8,809,058...8,809,910

G

TIMP metallopeptidase inhibitor 3

increases expression

corosolic acid results in increased expression of TIMP3 mRNA

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:17,521,919...17,571,839

G

tubulointerstitial nephritis antigen-like 1

increases expression

corosolic acid results in increased expression of TINAGL1 mRNA

NCBI chr 5:147,797,884...147,807,925
Ensembl chr 5:142,513,714...142,523,720

G

timeless interacting protein

decreases expression

corosolic acid results in decreased expression of TIPIN mRNA; corosolic acid results in decreased expression of TIPIN protein

NCBI chr 8:73,676,020...73,696,620
Ensembl chr 8:64,780,828...64,801,352
Ensembl chr 9:64,780,828...64,801,352

G

thymidine kinase 1

decreases expression

corosolic acid results in decreased expression of TK1 mRNA

NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,031,521...103,046,920

G

TLC domain containing 1

increases expression

corosolic acid results in increased expression of TLCD1 mRNA

NCBI chr10:63,572,541...63,574,574
Ensembl chr10:63,074,469...63,076,501

G

transmembrane BAX inhibitor motif containing 6

decreases expression

corosolic acid results in decreased expression of TMBIM6 mRNA

NCBI chr 7:132,405,217...132,422,492
Ensembl chr 7:130,527,316...130,543,633

G

transmembrane protein 11

decreases expression

corosolic acid results in decreased expression of TMEM11 mRNA

NCBI chr10:46,042,251...46,057,065
Ensembl chr10:45,542,755...45,557,570
Ensembl chr 6:45,542,755...45,557,570

G

transmembrane protein 141

increases expression

corosolic acid results in increased expression of TMEM141 mRNA

NCBI chr 3:28,837,665...28,839,623
Ensembl chr 3:8,439,533...8,441,491

G

tropomodulin 2

increases expression

corosolic acid results in increased expression of TMOD2 mRNA

NCBI chr 8:85,197,222...85,250,627
Ensembl chr 8:76,325,667...76,365,720

G

thiol methyltransferase 1A

decreases expression

corosolic acid results in decreased expression of TMT1A mRNA

NCBI chr 7:133,330,141...133,377,172
Ensembl chr 7:131,451,641...131,460,154

G

TNF receptor superfamily member 12A

increases expression

corosolic acid results in increased expression of TNFRSF12A mRNA

NCBI chr10:13,211,670...13,213,666
Ensembl chr10:12,689,890...12,709,045

G

TNFAIP3 interacting protein 1

increases expression

corosolic acid results in increased expression of TNIP1 mRNA

NCBI chr10:39,537,759...39,585,038
Ensembl chr10:39,037,058...39,077,625

G

tankyrase 1 binding protein 1

increases expression

corosolic acid results in increased expression of TNKS1BP1 mRNA

NCBI chr 3:90,542,006...90,566,720
Ensembl chr 3:70,137,837...70,160,038

G

tensin 4

decreases expression

corosolic acid results in decreased expression of TNS4 mRNA

NCBI chr10:84,518,179...84,537,558
Ensembl chr10:84,021,966...84,041,346

G

translocase of outer mitochondrial membrane 5

decreases expression

corosolic acid results in decreased expression of TOMM5 mRNA

NCBI chr 5:64,158,026...64,160,857
Ensembl chr 5:59,362,240...59,365,269

G

translocase of outer mitochondrial membrane 6

decreases expression

corosolic acid results in decreased expression of TOMM6 mRNA

NCBI chr 9:13,304,269...13,305,637

G

DNA topoisomerase II alpha

decreases expression

corosolic acid results in decreased expression of TOP2A mRNA; corosolic acid results in decreased expression of TOP2A protein

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p63 regulated 1-like

increases expression

corosolic acid results in increased expression of TPRG1L mRNA

NCBI chr 5:170,004,577...170,007,784
Ensembl chr 5:164,710,285...164,725,425

G

taperin

increases expression

corosolic acid results in increased expression of TPRN mRNA

NCBI chr 3:28,474,322...28,481,800
Ensembl chr 3:8,075,137...8,083,642

G

TPX2, microtubule nucleation factor

decreases expression

corosolic acid results in decreased expression of TPX2 mRNA; corosolic acid results in decreased expression of TPX2 protein

NCBI chr 3:161,778,709...161,820,941
Ensembl chr 3:141,318,455...141,360,468

G

trafficking protein particle complex subunit 13

increases expression

corosolic acid results in increased expression of TRAPPC13 mRNA

NCBI chr 2:37,004,288...37,035,837
Ensembl chr 2:35,269,183...35,302,048

G

trafficking protein particle complex subunit 2

increases expression

corosolic acid results in increased expression of TRAPPC2 mRNA

NCBI chr X:31,617,107...31,647,035
Ensembl chr X:27,994,054...28,015,346

G

TP53 regulated inhibitor of apoptosis 1

decreases expression

corosolic acid results in decreased expression of TRIAP1 mRNA

NCBI chr12:46,928,273...46,930,766
Ensembl chr12:41,267,549...41,270,042

G

tripartite motif-containing 65

increases expression

corosolic acid results in increased expression of TRIM65 mRNA

NCBI chr10:101,847,822...101,863,052
Ensembl chr10:101,357,937...101,364,971

G

thyroid hormone receptor interactor 11

decreases expression

corosolic acid results in decreased expression of TRIP11 mRNA

NCBI chr 6:126,760,263...126,832,619
Ensembl chr 6:120,998,733...121,067,781

G

TruB pseudouridine synthase family member 1

increases expression

corosolic acid results in increased expression of TRUB1 mRNA

NCBI chr 1:266,518,510...266,559,633
Ensembl chr 1:256,515,562...256,552,814

G

tsukushi, small leucine rich proteoglycan

increases expression

corosolic acid results in increased expression of TSKU mRNA

NCBI chr 1:162,071,459...162,082,972
Ensembl chr 1:152,656,693...152,672,588

G

tetratricopeptide repeat domain 13

increases expression

corosolic acid results in increased expression of TTC13 mRNA

NCBI chr19:69,534,989...69,589,590
Ensembl chr19:52,637,431...52,692,198

G

tetratricopeptide repeat domain 9

increases expression

corosolic acid results in increased expression of TTC9 mRNA

NCBI chr 6:107,064,527...107,099,361
Ensembl chr 6:101,333,141...101,368,110

G

thioredoxin 2

decreases expression

corosolic acid results in decreased expression of TXN2 mRNA

NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:109,496,761...109,510,359

G

tyrosine kinase 2

increases expression

corosolic acid results in increased expression of TYK2 mRNA

NCBI chr 8:27,918,054...27,943,319
Ensembl chr 8:19,641,884...19,667,044

G

thymidylate synthetase

decreases expression

corosolic acid results in decreased expression of TYMS mRNA; corosolic acid results in decreased expression of TYMS protein

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536

G

ubiquitin B

increases expression

corosolic acid results in increased expression of UBB mRNA; corosolic acid results in increased expression of UBB protein

NCBI chr10:47,746,923...47,748,628
Ensembl chr10:47,245,637...47,249,333

G

ubiquitin-conjugating enzyme E2C

decreases expression

corosolic acid results in decreased expression of UBE2C mRNA

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin-conjugating enzyme E2T

decreases expression

corosolic acid results in decreased expression of UBE2T mRNA

NCBI chr13:48,955,166...48,965,668
Ensembl chr13:46,403,375...46,414,835

G

unc-51 like autophagy activating kinase 1

multiple interactions

corosolic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of ULK1 protein]

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:45,851,710...45,877,966

G

unc-51 like kinase 3

increases expression

corosolic acid results in increased expression of ULK3 mRNA

NCBI chr 8:66,888,820...66,895,380
Ensembl chr 8:57,992,723...57,999,467

G

uracil-DNA glycosylase

decreases expression

corosolic acid results in decreased expression of UNG mRNA

NCBI chr12:48,145,838...48,154,789
Ensembl chr12:42,485,276...42,494,206

G

ubiquinol-cytochrome c reductase complex assembly factor 1

decreases expression

corosolic acid results in decreased expression of UQCC1 mRNA

NCBI chr 3:164,813,398...164,905,892
Ensembl chr 3:144,353,287...144,445,711

G

ubiquinol-cytochrome c reductase binding protein

decreases expression

corosolic acid results in decreased expression of UQCRB mRNA

NCBI chr 7:65,700,016...65,705,382
Ensembl chr 7:63,814,797...63,820,150

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

decreases expression

corosolic acid results in decreased expression of UQCRFS1 mRNA

NCBI chr17:34,173,787...34,190,952
Ensembl chr17:33,977,921...33,982,479

G

URI1, prefoldin-like chaperone

multiple interactions

corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of URI1 gene]

NCBI chr 1:99,783,157...99,845,787
Ensembl chr 1:90,646,393...90,709,026

G

ubiquitin specific peptidase 13

increases expression

corosolic acid results in increased expression of USP13 mRNA

NCBI chr 2:117,502,811...117,617,049
Ensembl chr 2:115,577,091...115,686,222

G

ubiquitin specific peptidase 33

increases expression

corosolic acid results in increased expression of USP33 mRNA

NCBI chr 2:243,938,958...243,988,424
Ensembl chr 2:241,292,985...241,328,479

G

vascular endothelial growth factor A

multiple interactions

corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

vestigial-like family member 1

increases expression

corosolic acid results in increased expression of VGLL1 mRNA

NCBI chr X:140,016,938...140,036,348

G

vitronectin

increases expression

corosolic acid results in increased expression of VTN mRNA

NCBI chr10:63,892,782...63,895,862
Ensembl chr10:63,394,719...63,397,810

G

WD repeat domain 76

decreases expression

corosolic acid results in decreased expression of WDR76 mRNA

NCBI chr 3:128,910,500...128,945,241
Ensembl chr 3:108,456,815...108,490,840

G

zinc finger CCCH-type containing 7B

increases expression

corosolic acid results in increased expression of ZC3H7B mRNA

NCBI chr 7:115,142,245...115,190,513
Ensembl chr 7:113,262,165...113,310,399

G

zinc finger protein 217

increases expression

corosolic acid results in increased expression of ZNF217 mRNA

NCBI chr 3:179,309,178...179,349,853
Ensembl chr 3:158,892,265...158,913,040

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19909
role	19880
biological role	19878
biochemical role	19586
metabolite	19573
corosolic acid	434
Path 2
Term	Annotations
CHEBI ontology	19909
subatomic particle	19907
composite particle	19907
hadron	19907
baryon	19907
nucleon	19907
atomic nucleus	19907
atom	19907
main group element atom	19846
main group molecular entity	19846
s-block molecular entity	19679
hydrogen molecular entity	19661
hydrides	19163
organic hydride	18713
organic fundamental parent	18713
hydrocarbon	18460
terpene	14086
triterpene	1270
triterpenoid	1266
corosolic acid	434

paths to the root