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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:coptisine
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Accession:CHEBI:67862 term browser browse the term
Definition:An alkaloid that has formula C19H14NO4.
Synonyms:related_synonym: Bis(1,3)benzodioxolo(5,6-a:4',5'-g)quinolizinium, 6,7-dihydro-;   Formula=C19H14NO4;   InChI=1S/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1;   InChIKey=XYHOBCMEDLZUMP-UHFFFAOYSA-N;   SMILES=C1Oc2cc3CC[n+]4cc5c6OCOc6ccc5cc4-c3cc2O1;   bis[methylenedioxy]protoberberine
 xref: CAS:3486-66-6;   KEGG:C16938
 xref_mesh: MESH:C034384
 xref: PMID:21401114


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coptisine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
EXP coptisine results in increased expression of ABCB1A mRNA; coptisine results in increased expression of ABCB1A protein
Dactinomycin inhibits the reaction [coptisine results in increased expression of ABCB1A mRNA]
CTD PMID:20410605 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression
multiple interactions
EXP coptisine results in increased expression of ABCB1B mRNA; coptisine results in increased expression of ABCB1B protein
Dactinomycin inhibits the reaction [coptisine results in increased expression of ABCB1B mRNA]
CTD PMID:20410605 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO coptisine analog results in decreased phosphorylation of AKT1 protein CTD PMID:30472432 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO coptisine analog results in increased expression of BAX protein CTD PMID:30472432 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO coptisine analog results in decreased expression of BCL2 protein CTD PMID:30472432 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases cleavage ISO coptisine analog results in increased cleavage of CASP3 protein CTD PMID:30472432 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage ISO coptisine analog results in increased cleavage of CASP9 protein CTD PMID:30472432 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO coptisine analog results in decreased expression of CDK2 protein CTD PMID:30472432 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO coptisine analog results in decreased expression of CDK4 protein CTD PMID:30472432 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO coptisine analog results in decreased expression of CDK6 protein CTD PMID:30472432 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        biochemical role 19333
          metabolite 19312
            coptisine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            heteroorganic entity 19226
                              organonitrogen compound 18407
                                alkaloid 5679
                                  coptisine 10
paths to the root