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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:coptisine
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Accession:CHEBI:67862 term browser browse the term
Definition:An alkaloid that has formula C19H14NO4.
Synonyms:related_synonym: Bis(1,3)benzodioxolo(5,6-a:4',5'-g)quinolizinium, 6,7-dihydro-;   Formula=C19H14NO4;   InChI=1S/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1;   InChIKey=XYHOBCMEDLZUMP-UHFFFAOYSA-N;   SMILES=C1Oc2cc3CC[n+]4cc5c6OCOc6ccc5cc4-c3cc2O1;   bis[methylenedioxy]protoberberine
 xref: CAS:3486-66-6;   KEGG:C16938
 xref_mesh: MESH:C034384
 xref: PMID:21401114


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coptisine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions		 EXP coptisine results in increased expression of ABCB1A mRNA; coptisine results in increased expression of ABCB1A protein
Dactinomycin inhibits the reaction [coptisine results in increased expression of ABCB1A mRNA]		 CTD PMID:20410605 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression
multiple interactions		 EXP coptisine results in increased expression of ABCB1B mRNA; coptisine results in increased expression of ABCB1B protein
Dactinomycin inhibits the reaction [coptisine results in increased expression of ABCB1B mRNA]		 CTD PMID:20410605 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
increases phosphorylation		 ISO coptisine analog results in decreased phosphorylation of AKT1 protein
coptisine results in increased phosphorylation of AKT1 protein		 CTD PMID:30472432 PMID:32535096 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO coptisine analog results in increased expression of BAX protein CTD PMID:30472432 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO coptisine analog results in decreased expression of BCL2 protein CTD PMID:30472432 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO coptisine analog results in increased cleavage of CASP3 protein CTD PMID:30472432 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO coptisine analog results in increased cleavage of CASP9 protein CTD PMID:30472432 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO coptisine analog results in decreased expression of CDK2 protein CTD PMID:30472432 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO coptisine analog results in decreased expression of CDK4 protein CTD PMID:30472432 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO coptisine analog results in decreased expression of CDK6 protein CTD PMID:30472432 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO [Xiao-Ke-An results in increased abundance of coptisine] which results in decreased activity of DPP4 protein CTD PMID:32535096 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        biochemical role 19574
          metabolite 19561
            coptisine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organonitrogen compound 18855
                                alkaloid 8026
                                  coptisine 11
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