Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(R)-mevalonolactone
go back to main search page
Accession:CHEBI:67849 term browser browse the term
Definition:A 4-hydroxy-4-methyloxan-2-one that has (R)-configuration. It is a natural product found in Phomopsis archeri.
Synonyms:related_synonym: (-)-(R)-mevalonic acid lactone;   (-)-mevalonolactone;   (4R)-4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one;   (4R)-4-hydroxy-4-methyloxan-2-one;   D-Mevalonolactone;   D-mevalonic acid lactone;   Formula=C6H10O3;   InChI=1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3/t6-/m1/s1;   InChIKey=JYVXNLLUYHCIIH-ZCFIWIBFSA-N;   SMILES=C[C@@]1(O)CCOC(=O)C1
 xref: CAS:19115-49-2;   LINCS:LSM-6716;   PMID:11667258;   PMID:20460804;   PMID:22905894;   PMID:23964677;   PMID:24431105;   PMID:32691474;   PMID:9208099
 cyclic_relationship: is_enantiomer_of CHEBI:194428


show annotations for term's descendants           Sort by:
mevalonolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO mevalonolactone results in decreased activity of HMGCR protein CTD PMID:3042028 PMID:12477733 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Ptgir prostaglandin I2 receptor affects binding ISO mevalonolactone binds to PTGIR protein CTD PMID:11895442 NCBI chr 1:77,579,596...77,581,979
Ensembl chr 1:77,579,596...77,581,979 		JBrowse link
G Rap2a RAP2A, member of RAS oncogene family increases farnesylation ISO mevalonolactone results in increased farnesylation of RAP2A protein CTD PMID:8424780 NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138 		JBrowse link
G Rap2b RAP2B, member of RAS oncogene family increases prenylation ISO mevalonolactone results in increased prenylation of RAP2B protein CTD PMID:8424780 NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        biochemical role 19586
          metabolite 19573
            eukaryotic metabolite 19400
              plant metabolite 18035
                (R)-mevalonolactone 4
                  mevalonolactone 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  ester 17582
                                    carboxylic ester 16981
                                      lactone 13311
                                        delta-lactone 4213
                                          2-pyranones 772
                                            4-hydroxy-4-methyloxan-2-one 4
                                              (R)-mevalonolactone 4
                                                mevalonolactone 4
paths to the root