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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mesalamine
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Accession:CHEBI:6775 term browser browse the term
Definition:A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.
Synonyms:exact_synonym: 5-amino-2-hydroxybenzoic acid
 related_synonym: 3-carboxy-4-hydroxyaniline;   5-ASA;   5-Aminosalicylic acid;   Asacol;   Asacolitin;   Canasa;   Claversal;   Fisalamine;   Formula=C7H7NO3;   Iialda;   InChI=1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11);   InChIKey=KBOPZPXVLCULAV-UHFFFAOYSA-N;   Lixacol;   Mesalazina;   Mesalazinum;   Mesasal;   Pentasa;   Rowasa;   SMILES=Nc1ccc(O)c(c1)C(O)=O;   Salofalk;   m-Aminosalicylic acid;   mesalazine;   p-Aminosalicylsaeure
 xref: Beilstein:2090421;   CAS:89-57-6;   DrugBank:DB00244;   Drug_Central:1710;   HMDB:HMDB0014389;   KEGG:D00377;   LINCS:LSM-5427
 xref_mesh: MESH:D019804
 xref: MetaCyc:CPD-12711;   PMID:10648473;   PMID:22304735;   PMID:22648999;   PMID:23137838;   PMID:23146664;   PMID:23302220;   PMID:28166217;   Reaxys:2090421;   Wikipedia:Mesalamine
 cyclic_relationship: is_conjugate_acid_of CHEBI:20551



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mesalamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Mesalamine inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] CTD PMID:29738702 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein] CTD PMID:33412153 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Alb albumin multiple interactions EXP Mesalamine inhibits the reaction [Thioacetamide results in decreased expression of ALB protein] CTD PMID:29738702 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions EXP Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARRB1 mRNA]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARRB1 protein] CTD PMID:24637189 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in increased expression of BAX mRNA] CTD PMID:29518435 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in decreased expression of BCL2 mRNA]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL2 mRNA]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL2 protein] CTD PMID:24637189 PMID:29518435 PMID:33412153 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in increased activity of and results in increased cleavage of CASP1 protein] CTD PMID:37001609 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in increased expression of CASP3 mRNA]; Mesalamine inhibits the reaction [Thioacetamide affects the expression of CASP3 protein]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:29518435 PMID:29738702 PMID:33412153 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO [Mesalamine co-treated with Glucocorticoids] results in decreased expression of CCL20 mRNA; Mesalamine results in decreased expression of [IL1B protein results in increased expression of CCL20 protein]; Mesalamine results in decreased expression of [TNF protein results in increased expression of CCL20 protein] CTD PMID:16306769 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of CCL3 mRNA] CTD PMID:33130971 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion ISO Mesalamine results in increased secretion of CXCL1 protein CTD PMID:12231210 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases secretion ISO Mesalamine results in increased secretion of CXCL1 protein CTD PMID:12231210 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in decreased expression of DUSP1 mRNA] CTD PMID:35122774 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of GCLC mRNA CTD PMID:27818126 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Mesalamine promotes the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of GCLM mRNA] CTD PMID:27818126 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Mesalamine inhibits the reaction [Thioacetamide results in increased activity of GPT protein] CTD PMID:29738702 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in increased cleavage of GSDMD protein] CTD PMID:37001609 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Hk1 hexokinase 1 multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of HK1 protein] CTD PMID:37001609 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HMGB1 protein] CTD PMID:33412153 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP
Mesalamine inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with resveratrol] results in increased expression of HMOX1 mRNA]
Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of HMOX1 protein]
CTD PMID:27818126 PMID:33412153 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsf1 heat shock transcription factor 1 decreases activity ISO Mesalamine results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Ifng interferon gamma multiple interactions ISO [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased activity of NFE2L2 protein; [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of GCLC mRNA; [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of PPARG protein; Mesalamine inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with cyanidin-3-O-beta-glucopyranoside] results in increased expression of PPARG protein]; Mesalamine inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Resveratrol] results in increased expression of HMOX1 mRNA]; Mesalamine promotes the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of GCLM mRNA] CTD PMID:27818126 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in decreased expression of IL10 protein]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein] CTD PMID:33412153 PMID:35122774 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of IL12B mRNA] CTD PMID:33130971 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of IL17A mRNA] CTD PMID:33130971 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in increased secretion of IL18 protein] CTD PMID:37001609 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased activity of NFE2L2 protein; [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of GCLC mRNA; [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of PPARG protein; Mesalamine inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with cyanidin-3-O-beta-glucopyranoside] results in increased expression of PPARG protein]; Mesalamine inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Resveratrol] results in increased expression of HMOX1 mRNA]; Mesalamine promotes the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of GCLM mRNA] CTD PMID:27818126 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO
EXP
Mesalamine results in increased expression of IL1B mRNA
Mesalamine results in decreased expression of [IL1B protein results in increased expression of CCL20 protein]
[allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Mesalamine inhibits the reaction [Acetic Acid results in increased expression of IL1B mRNA]; Mesalamine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
Mesalamine inhibits the reaction [Dextran Sulfate results in increased cleavage of IL1B protein]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]
CTD PMID:10743803 PMID:16306769 PMID:25729217 PMID:29518435 PMID:33130971 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Mesalamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 protein] CTD PMID:7815356 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO Mesalamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein] CTD PMID:7815356 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Il4 interleukin 4 multiple interactions EXP [allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased secretion of IL4 protein] CTD PMID:25729217 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased secretion of IL6 protein]
Mesalamine inhibits the reaction [Acetic Acid results in increased expression of IL6 protein]
CTD PMID:33130971 PMID:35122774 PMID:36543318 PMID:37001609 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in increased phosphorylation of JAK2 protein] CTD PMID:35122774 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of and affects the localization of JUN protein] CTD PMID:33130971 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in increased expression of MAPK14 mRNA] CTD PMID:29518435 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
Mesalamine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
Mesalamine inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
CTD PMID:25079872 PMID:29518435 PMID:30365937 PMID:33130971 PMID:33412153 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in increased expression of MTOR mRNA]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of MTOR protein] CTD PMID:33412153 PMID:35122774 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nat1 N-acetyltransferase 1 increases acetylation ISO NAT1 protein results in increased acetylation of Mesalamine CTD PMID:15627487 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of Mesalamine CTD PMID:15627487 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP
[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased activity of NFE2L2 protein
Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid affects the expression of NFE2L2 protein]
CTD PMID:27818126 PMID:33412153 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein] CTD PMID:37001609 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Mesalamine inhibits the reaction [Acetic Acid results in increased expression of NOS2 mRNA]
Mesalamine inhibits the reaction [Dextran Sulfate results in increased activity of NOS2 protein]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]
CTD PMID:29518435 PMID:33130971 PMID:36543318 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in decreased expression of NR0B2 mRNA] CTD PMID:35122774 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions EXP Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 mRNA]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 protein] CTD PMID:24637189 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Mesalamine results in increased cleavage of PARP1 protein CTD PMID:12663503 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of PPARG protein; Mesalamine inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with cyanidin-3-O-beta-glucopyranoside] results in increased expression of PPARG protein]
Mesalamine inhibits the reaction [Dextran Sulfate affects the localization of PPARG protein]
CTD PMID:27818126 PMID:33130971 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in decreased expression of PPARGC1A mRNA] CTD PMID:35122774 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein] CTD PMID:36543318 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein] CTD PMID:29518435 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
Mesalamine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Mesalamine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]; Mesalamine results in increased expression of and affects the localization of RELA protein
CTD PMID:33130971 PMID:33412153 PMID:35122774 PMID:36543318 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in decreased expression of SIRT1 mRNA] CTD PMID:35122774 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases uptake
multiple interactions
ISO SLCO1B3 protein results in increased uptake of Mesalamine
Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]; Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]; Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]
CTD PMID:21430235 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions
increases uptake
ISO Budesonide inhibits the reaction [SLCO2B1 protein results in increased uptake of Mesalamine]; Cyclosporine inhibits the reaction [SLCO2B1 protein results in increased uptake of Mesalamine]; Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Mesalamine]; Rifampin inhibits the reaction [SLCO2B1 protein results in increased uptake of Mesalamine] CTD PMID:21430235 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in increased expression of SOCS3 mRNA] CTD PMID:35122774 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Mesalamine inhibits the reaction [Thioacetamide results in increased expression of SPP1 protein] CTD PMID:29738702 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SQSTM1 protein] CTD PMID:33412153 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP
ISO
Mesalamine inhibits the reaction [Acetic Acid results in increased phosphorylation of STAT3 protein]
Mesalamine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of STAT3 protein]
CTD PMID:35122774 PMID:36543318 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Mesalamine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein] CTD PMID:29738702 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Mesalamine results in increased expression of TIMP2 mRNA CTD PMID:10743803 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein] CTD PMID:36543318 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased activity of NFE2L2 protein; [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of GCLC mRNA; [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of PPARG protein; Mesalamine inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with cyanidin-3-O-beta-glucopyranoside] results in increased expression of PPARG protein]; Mesalamine inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Resveratrol] results in increased expression of HMOX1 mRNA]; Mesalamine promotes the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of GCLM mRNA]; Mesalamine promotes the reaction [Endotoxins results in increased expression of TNF protein]; Mesalamine results in decreased expression of [TNF protein results in increased expression of CCL20 protein]
[allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Mesalamine inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Mesalamine inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased secretion of TNF protein]
CTD PMID:7496871 PMID:16306769 PMID:25729217 PMID:27818126 PMID:29518435 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tollip toll interacting protein multiple interactions ISO Mesalamine inhibits the reaction [Dextran Sulfate results in decreased expression of TOLLIP protein] CTD PMID:36543318 NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625
JBrowse link
G Tpm3 tropomyosin 3 decreases expression ISO Mesalamine results in decreased expression of TPM3 mRNA alternative form; Mesalamine results in decreased expression of TPM3 protein alternative form CTD PMID:19369484 NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Mesalamine inhibits the reaction [Acetic Acid results in increased expression of VEGFA mRNA] CTD PMID:29518435 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        antimicrobial agent 18193
          antifungal agent 16863
            salicylic acid 1551
              mesalamine 64
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            heteroorganic entity 19495
                              organochalcogen compound 19257
                                organooxygen compound 19175
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      aromatic carboxylic acid 12617
                                        benzoic acids 12594
                                          benzoic acid 5335
                                            hydroxybenzoic acid 4806
                                              monohydroxybenzoic acid 2620
                                                salicylic acid 1551
                                                  mesalamine 64
paths to the root