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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Mesaconitine
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Accession:CHEBI:6773 term browser browse the term
Definition:A diterpenoid that has formula C33H45NO11.
Synonyms:related_synonym: Formula=C33H45NO11;   InChI=1S/C33H45NO11/c1-16(35)45-33-21-18(13-31(39,28(43-6)26(33)37)27(21)44-29(38)17-10-8-7-9-11-17)32-20(41-4)12-19(36)30(15-40-3)14-34(2)25(32)22(33)23(42-5)24(30)32/h7-11,18-28,36-37,39H,12-15H2,1-6H3/t18-,19-,20+,21-,22+,23+,24-,25?,26+,27-,28+,30+,31-,32+,33-/m1/s1;   InChIKey=XUHJBXVYNBQQBD-TUWOXVOMSA-N;   SMILES=COC[C@]12CN(C)C3[C@@H]4[C@H](OC)[C@H]1[C@]3([C@@H]1C[C@@]3(O)[C@H](OC(=O)c5ccccc5)[C@@H]1[C@]4(OC(C)=O)[C@@H](O)[C@@H]3OC)[C@H](C[C@H]2O)OC
 xref: CAS:2752-64-9;   KEGG:C08698;   KNApSAcK:C00001654;   KNApSAcK:C00028576
 xref_mesh: MESH:C019470



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Mesaconitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects response to substance
increases transport
ISO [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of mesaconitine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of mesaconitine
ABCB1A protein affects the susceptibility to mesaconitine
[ABCB1A protein affects the susceptibility to mesaconitine] which affects the expression of S100B protein
ABCB1 protein results in increased transport of mesaconitine
CTD PMID:23200901 PMID:33171190 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of mesaconitine CTD PMID:23200901 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases transport
affects response to substance
ISO [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased transport of mesaconitine
ABCG2 protein results in increased transport of mesaconitine
ABCG2 protein affects the susceptibility to mesaconitine
CTD PMID:23200901 PMID:33171190 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO [ABCB1A protein affects the susceptibility to mesaconitine] which affects the expression of S100B protein CTD PMID:33171190 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          carbon atom 19609
            organic molecular entity 19609
              isoprenoid 12725
                terpenoid 12295
                  diterpenoid 11518
                    Mesaconitine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            organic hydride 18348
                              organic fundamental parent 18348
                                hydrocarbon 18059
                                  terpene 12725
                                    diterpene 11518
                                      diterpenoid 11518
                                        Mesaconitine 4
paths to the root