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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Longikaurin A
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Accession:CHEBI:67677 term browser browse the term
Definition:A kaurane diterpenoid that has formula C20H28O5.
Synonyms:related_synonym: Formula=C20H28O5;   InChI=1S/C20H28O5/c1-10-11-5-6-12-18-8-4-7-17(2,3)13(18)16(23)20(24,25-9-18)19(12,14(10)21)15(11)22/h11-13,15-16,22-24H,1,4-9H2,2-3H3/t11-,12+,13-,15-,16+,18-,19+,20-/m1/s1;   InChIKey=PSVHVXLCVSKJGM-NIPWPZGFSA-N;   SMILES=[H][C@]12CC[C@@]3([H])[C@]45CCCC(C)(C)[C@@]4([H])[C@H](O)[C@@](O)(OC5)[C@]3([C@@H]1O)C(=O)C2=C;   ent-Kaur-16-en-15-one, 7,20-epoxy-6,7,14-trihydroxy-,(6beta,7alpha,14R)-
 xref: CAS:75207-67-9
 xref_mesh: MESH:C581034
 xref: PMID:21534539


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Longikaurin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO longikaurin A results in increased expression of BAX protein CTD PMID:28801140 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO longikaurin A results in decreased expression of BCL2 protein CTD PMID:28801140 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases expression ISO longikaurin A results in increased expression of CASP3 protein modified form CTD PMID:28801140 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases expression ISO longikaurin A results in increased expression of CASP9 protein modified form CTD PMID:28801140 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO longikaurin A results in decreased expression of CCNB1 protein CTD PMID:28801140 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO longikaurin A results in decreased expression of CDK1 protein CTD PMID:28801140 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO longikaurin A results in increased expression of CYCS protein CTD PMID:28801140 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G H2ax H2A.X variant histone increases expression ISO longikaurin A results in increased expression of H2AX protein modified form CTD PMID:28801140 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO longikaurin A results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [longikaurin A results in increased phosphorylation of MAPK8 protein]
CTD PMID:28801140 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [longikaurin A results in increased phosphorylation of MAPK9 protein] CTD PMID:28801140 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO longikaurin A results in increased expression of PARP1 protein modified form CTD PMID:28801140 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            Longikaurin A 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  terpene 9594
                                    terpenoid 9578
                                      diterpenoid 8426
                                        kaurane diterpenoid 11
                                          Longikaurin A 11
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