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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Longikaurin A
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Accession:CHEBI:67677 term browser browse the term
Definition:A kaurane diterpenoid that has formula C20H28O5.
Synonyms:related_synonym: Formula=C20H28O5;   InChI=1S/C20H28O5/c1-10-11-5-6-12-18-8-4-7-17(2,3)13(18)16(23)20(24,25-9-18)19(12,14(10)21)15(11)22/h11-13,15-16,22-24H,1,4-9H2,2-3H3/t11-,12+,13-,15-,16+,18-,19+,20-/m1/s1;   InChIKey=PSVHVXLCVSKJGM-NIPWPZGFSA-N;   SMILES=[H][C@]12CC[C@@]3([H])[C@]45CCCC(C)(C)[C@@]4([H])[C@H](O)[C@@](O)(OC5)[C@]3([C@@H]1O)C(=O)C2=C;   ent-Kaur-16-en-15-one, 7,20-epoxy-6,7,14-trihydroxy-,(6beta,7alpha,14R)-
 xref: CAS:75207-67-9
 xref_mesh: MESH:C581034
 xref: PMID:21534539



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Longikaurin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO longikaurin A results in increased expression of BAX protein CTD PMID:28801140 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO longikaurin A results in decreased expression of BCL2 protein CTD PMID:28801140 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression ISO longikaurin A results in increased expression of CASP3 protein modified form CTD PMID:28801140 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases expression ISO longikaurin A results in increased expression of CASP9 protein modified form CTD PMID:28801140 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO longikaurin A results in decreased expression of CCNB1 protein CTD PMID:28801140 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO longikaurin A results in decreased expression of CDK1 protein CTD PMID:28801140 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO longikaurin A results in increased expression of CYCS protein CTD PMID:28801140 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G H2ax H2A.X variant histone increases expression ISO longikaurin A results in increased expression of H2AX protein modified form CTD PMID:28801140 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO longikaurin A results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [longikaurin A results in increased phosphorylation of MAPK8 protein]
CTD PMID:28801140 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [longikaurin A results in increased phosphorylation of MAPK9 protein] CTD PMID:28801140 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO longikaurin A results in increased expression of PARP1 protein modified form CTD PMID:28801140 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            Longikaurin A 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    main group molecular entity 19960
                      s-block molecular entity 19784
                        hydrogen molecular entity 19777
                          hydrides 19115
                            organic hydride 18675
                              organic fundamental parent 18657
                                hydrocarbon 18408
                                  terpene 13630
                                    terpenoid 13293
                                      diterpenoid 12731
                                        kaurane diterpenoid 11
                                          Longikaurin A 11
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