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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mepyramine
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Accession:CHEBI:6762 term browser browse the term
Definition:An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Synonyms:exact_synonym: N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine
 related_synonym: Formula=C17H23N3O;   InChI=1S/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3;   InChIKey=YECBIJXISLIIDS-UHFFFAOYSA-N;   N',N'-dimethyl-N-(p-methoxybenzyl)-N-(2-pyridyl)ethylenediamine;   N-(p-methoxybenzyl)-N',N'-dimethyl-N-(alpha-pyridyl)ethylenediamine;   N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine;   Pyrilamine;   SMILES=COc1ccc(CN(CCN(C)C)c2ccccn2)cc1;   pyranisamine
 xref: Beilstein:269019;   CAS:91-84-9;   DrugBank:DB06691;   Drug_Central:2331;   Gmelin:877512;   HMDB:HMDB0015639;   KEGG:C11798;   KEGG:D08183;   LINCS:LSM-4206
 xref_mesh: MESH:D011738
 xref: PMID:24316866;   PMID:24813183;   Reaxys:269019;   Wikipedia:Pyrilamine



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mepyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO Pyrilamine results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Pyrilamine inhibits the reaction [Histamine results in increased activity of F3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of F3] CTD PMID:16009787 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
decreases activity
affects binding
ISO
EXP
Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein]; Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]]; Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Pyrilamine results in decreased susceptibility to CXCL8 protein]; Lipopolysaccharides promotes the reaction [Pyrilamine binds to HRH1 protein]; Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein]; Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein]
Pyrilamine results in decreased activity of HRH1 protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Pyrilamine binds to HRH1 protein]; [Pyrilamine binds to and results in decreased activity of HRH1 protein] which results in decreased susceptibility to clobenpropit; Pyrilamine binds to and results in decreased activity of HRH1 protein; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine]; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]; Tacrine inhibits the reaction [Pyrilamine binds to HRH1 protein]; Toluene 2,4-Diisocyanate promotes the reaction [Pyrilamine binds to HRH1 protein]
CTD PMID:1912125 PMID:2419744 PMID:2606156 PMID:3379823 PMID:7522859 More... NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
affects activity
ISO Pyrilamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Pyrilamine affects the activity of KCNH2 protein
CTD PMID:16278312 PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kng2 kininogen 2 decreases activity ISO Pyrilamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:16009787 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:16009787 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] CTD PMID:15167971 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP [Pyrilamine co-treated with Famotidine co-treated with ciproxifan] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Pyrilamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO carebastine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Cyproheptadine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; ebastine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Promethazine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Promethazine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine; SLC22A5 protein affects the transport of and affects the abundance of Pyrilamine CTD PMID:19821448 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Pyrilamine analog binds to and affects the activity of SLC6A3 protein CTD PMID:11931612 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects binding ISO Pyrilamine analog binds to SLC6A4 protein CTD PMID:11931612 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        refrigerant 17688
          ethane 6314
            ethylenediamine 3737
              ethylenediamine derivative 3563
                mepyramine 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            inorganic hydride 17691
                              pnictogen hydride 17671
                                nitrogen hydride 17543
                                  azane 17278
                                    ammonia 17277
                                      organic amino compound 17277
                                        polyamine 8277
                                          diamine 8205
                                            primary diamine 5677
                                              alkane-alpha,omega-diamine 3762
                                                ethylenediamine 3737
                                                  ethylenediamine derivative 3563
                                                    mepyramine 13
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