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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mepyramine
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Accession:CHEBI:6762 term browser browse the term
Definition:An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Synonyms:exact_synonym: N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine
 related_synonym: Formula=C17H23N3O;   InChI=1S/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3;   InChIKey=YECBIJXISLIIDS-UHFFFAOYSA-N;   N',N'-dimethyl-N-(p-methoxybenzyl)-N-(2-pyridyl)ethylenediamine;   N-(p-methoxybenzyl)-N',N'-dimethyl-N-(alpha-pyridyl)ethylenediamine;   N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine;   Pyrilamine;   SMILES=COc1ccc(CN(CCN(C)C)c2ccccn2)cc1;   pyranisamine
 xref: Beilstein:269019;   CAS:91-84-9;   DrugBank:DB06691;   Drug_Central:2331;   Gmelin:877512;   HMDB:HMDB0015639;   KEGG:C11798;   KEGG:D08183;   LINCS:LSM-4206
 xref_mesh: MESH:D011738
 xref: PMID:24316866;   PMID:24813183;   Reaxys:269019;   Wikipedia:Pyrilamine


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mepyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO Pyrilamine results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Pyrilamine inhibits the reaction [Histamine results in increased activity of F3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of F3] CTD PMID:16009787 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
decreases activity
affects binding
ISO
EXP
Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein]; Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]]; Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Pyrilamine results in decreased susceptibility to CXCL8 protein]; Lipopolysaccharides promotes the reaction [Pyrilamine binds to HRH1 protein]; Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein]; Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein]
Pyrilamine results in decreased activity of HRH1 protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Pyrilamine binds to HRH1 protein]; [Pyrilamine binds to and results in decreased activity of HRH1 protein] which results in decreased susceptibility to clobenpropit; Pyrilamine binds to and results in decreased activity of HRH1 protein; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine]; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]; Tacrine inhibits the reaction [Pyrilamine binds to HRH1 protein]; Toluene 2,4-Diisocyanate promotes the reaction [Pyrilamine binds to HRH1 protein]
CTD PMID:1912125 PMID:2419744 PMID:2606156 PMID:3379823 PMID:7522859 PMID:8111568 PMID:9832392 PMID:11640976 PMID:11927170 PMID:15167971 PMID:15513549 PMID:16488453 PMID:19215234 PMID:21255012 PMID:21276809 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
affects activity
ISO Pyrilamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Pyrilamine affects the activity of KCNH2 protein
CTD PMID:16278312 PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kng2 kininogen 2 decreases activity ISO Pyrilamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:16009787 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:16009787 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] CTD PMID:15167971 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP [Pyrilamine co-treated with Famotidine co-treated with ciproxifan] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Pyrilamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO carebastine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Cyproheptadine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; ebastine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Promethazine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Promethazine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine; SLC22A5 protein affects the transport of and affects the abundance of Pyrilamine CTD PMID:19821448 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Pyrilamine analog binds to and affects the activity of SLC6A3 protein CTD PMID:11931612 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects binding ISO Pyrilamine analog binds to SLC6A4 protein CTD PMID:11931612 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      application 19413
        refrigerant 17474
          ethane 6302
            ethylenediamine 3729
              ethylenediamine derivative 3563
                mepyramine 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    main group molecular entity 19665
                      s-block molecular entity 19430
                        hydrogen molecular entity 19424
                          hydrides 18758
                            inorganic hydride 17457
                              pnictogen hydride 17432
                                nitrogen hydride 17277
                                  azane 17009
                                    ammonia 17008
                                      organic amino compound 17007
                                        polyamine 8261
                                          diamine 8188
                                            primary diamine 5660
                                              alkane-alpha,omega-diamine 3754
                                                ethylenediamine 3729
                                                  ethylenediamine derivative 3563
                                                    mepyramine 13
paths to the root