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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mephobarbital
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Accession:CHEBI:6758 term browser browse the term
Definition:A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by ethyl and phenyl groups.
Synonyms:exact_synonym: 5-ethyl-1-methyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
 related_synonym: 1-methylphenobarbital;   5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trione;   5-ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione;   5-ethyl-1-methyl-5-phenylbarbituric acid;   Formula=C13H14N2O3;   InChI=1S/C13H14N2O3/c1-3-13(9-7-5-4-6-8-9)10(16)14-12(18)15(2)11(13)17/h4-8H,3H2,1-2H3,(H,14,16,18);   InChIKey=ALARQZQTBTVLJV-UHFFFAOYSA-N;   Mebaral;   Mephobarbitone;   N-methylphenobarbital;   SMILES=CCC1(C(=O)NC(=O)N(C)C1=O)c1ccccc1;   methylphenobarbital;   methylphenobarbitalum;   metilfenobarbital
 alt_id: CHEBI:165567
 xref: Beilstein:256144;   CAS:115-38-8;   DrugBank:DB00849;   Drug_Central:1696;   Gmelin:282754;   HMDB:HMDB0014987;   KEGG:C07829;   KEGG:D00700
 xref_mesh: MESH:D008618
 xref: PMID:12873507;   PMID:1455071;   PMID:2083148;   PMID:22342565;   PMID:2249375;   PMID:3298402;   PMID:3654008;   PMID:553327;   PMID:6094812;   Reaxys:256144;   Wikipedia:Methylphenobarbital


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mephobarbital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Mephobarbital CTD PMID:12464242 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Mephobarbital binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biophysical role 14060
          membrane transport modulator 13902
            GABA modulator 5115
              barbiturates 4636
                mephobarbital 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteromonocyclic compound 17794
                                    diazines 13228
                                      pyrimidines 13094
                                        pyrimidone 10509
                                          barbiturates 4636
                                            mephobarbital 2
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