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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mephobarbital
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Accession:CHEBI:6758 term browser browse the term
Definition:A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by ethyl and phenyl groups.
Synonyms:exact_synonym: 5-ethyl-1-methyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
 related_synonym: 1-methylphenobarbital;   5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trione;   5-ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione;   5-ethyl-1-methyl-5-phenylbarbituric acid;   Formula=C13H14N2O3;   InChI=1S/C13H14N2O3/c1-3-13(9-7-5-4-6-8-9)10(16)14-12(18)15(2)11(13)17/h4-8H,3H2,1-2H3,(H,14,16,18);   InChIKey=ALARQZQTBTVLJV-UHFFFAOYSA-N;   Mebaral;   Mephobarbitone;   N-methylphenobarbital;   SMILES=CCC1(C(=O)NC(=O)N(C)C1=O)c1ccccc1;   methylphenobarbital;   methylphenobarbitalum;   metilfenobarbital
 alt_id: CHEBI:165567
 xref: Beilstein:256144;   CAS:115-38-8;   DrugBank:DB00849;   Drug_Central:1696;   Gmelin:282754;   HMDB:HMDB0014987;   KEGG:C07829;   KEGG:D00700
 xref_mesh: MESH:D008618
 xref: PMID:12873507;   PMID:1455071;   PMID:2083148;   PMID:22342565;   PMID:2249375;   PMID:3298402;   PMID:3654008;   PMID:553327;   PMID:6094812;   Reaxys:256144;   Wikipedia:Methylphenobarbital


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mephobarbital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Mephobarbital CTD PMID:12464242 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Mephobarbital binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link

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  CHEBI ontology 19875
    role 19825
      biological role 19825
        biophysical role 12669
          membrane transport modulator 12467
            GABA modulator 4658
              barbiturates 4387
                mephobarbital 2
Path 2
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  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic heterocyclic compound 18511
                                  organic heteromonocyclic compound 16621
                                    diazines 12215
                                      pyrimidines 12036
                                        pyrimidone 8841
                                          barbiturates 4387
                                            mephobarbital 2
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