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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mephenytoin
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Accession:CHEBI:6757 term browser browse the term
Definition:An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Synonyms:exact_synonym: 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione
 related_synonym: DL-Mephenytoin;   Formula=C12H14N2O2;   InChI=1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16);   InChIKey=GMHKMTDVRCWUDX-UHFFFAOYSA-N;   SMILES=CCC1(C(=O)N(C(=O)N1)C)C2=CC=CC=C2;   mefenitoina;   mephenytoine;   mephenytoinum;   methylphenetoin;   phenylethylmethylhydantoin
 alt_id: CHEBI:91914
 xref: CAS:50-12-4;   Drug_Central:1695;   KEGG:D00375;   LINCS:LSM-1852
 xref_mesh: MESH:D008617
 xref: PMID:11422005;   PMID:15282764;   PMID:25797720;   PMID:29438107;   Reaxys:17282;   Wikipedia:Mephenytoin


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mephenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases hydroxylation EXP CYP2B6 protein results in increased hydroxylation of Mephenytoin CTD PMID:12637241 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
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  CHEBI ontology 494
    role 501
      application 452
        pharmaceutical 453
          drug 446
            central nervous system drug 75
              central nervous system depressant 71
                anticonvulsant 45
                  mephenytoin 1
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  CHEBI ontology 494
    subatomic particle 494
      composite particle 494
        hadron 501
          baryon 494
            nucleon 494
              atomic nucleus 494
                atom 494
                  main group element atom 487
                    p-block element atom 487
                      carbon group element atom 476
                        carbon atom 482
                          organic molecular entity 475
                            organic molecule 466
                              organic cyclic compound 449
                                organic heterocyclic compound 419
                                  organic heteromonocyclic compound 334
                                    diazolidine 3
                                      imidazolidines 3
                                        imidazolidinone 3
                                          imidazolidine-2,4-dione 3
                                            mephenytoin 1
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