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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5Z-7-oxozeaenol
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Accession:CHEBI:67559 term browser browse the term
Definition:A macrolide that is the 7-oxo derivative of zeaenol (the 5Z stereoisomer). Isolated from Fungi, it exhibits cytotoxic, antibacterial and inhibitory activity against NF-kappaB.
Synonyms:exact_synonym: (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
 related_synonym: Formula=C19H22O7;   InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1;   InChIKey=NEQZWEXWOFPKOT-BYRRXHGESA-N;   LL-Z1640-2;   SMILES=COc1cc(O)c2C(=O)O[C@@H](C)C\\C=C/C(=O)[C@@H](O)[C@@H](O)C\\C=C\\c2c1
 xref: PMID:21513293;   Reaxys:8800797


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5Z-7-oxozeaenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO (5Z)-7-oxozeaenol decreases expression of BIRC3 protein in esophageal adenocarcinoma cells RGD PMID:26291056 RGD:152999007 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases phosphorylation ISO 5Z-7-oxozeaenol decreases phosphorylation of Map3k7 protein in hypertrophic heart RGD PMID:26891723 RGD:11555743 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        biochemical role 19496
          metabolite 19484
            5Z-7-oxozeaenol 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbonyl compound 18858
                                    ketone 17163
                                      oxyketone 8906
                                        alpha-oxyketone 8900
                                          alpha-hydroxy ketone 8900
                                            secondary alpha-hydroxy ketone 1037
                                              5Z-7-oxozeaenol 2
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