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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gamma-mangostin
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Accession:CHEBI:67548 term browser browse the term
Definition:A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity.
Synonyms:exact_synonym: 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
 related_synonym: Formula=C23H24O6;   InChI=1S/C23H24O6/c1-11(2)5-7-13-15(24)9-18-20(22(13)27)23(28)19-14(8-6-12(3)4)21(26)16(25)10-17(19)29-18/h5-6,9-10,24-27H,7-8H2,1-4H3;   InChIKey=VEZXFTKZUMARDU-UHFFFAOYSA-N;   SMILES=CC(C)=CCc1c(O)cc2oc3cc(O)c(O)c(CC=C(C)C)c3c(=O)c2c1O
 xref: CAS:31271-07-5;   HMDB:HMDB0035795
 xref_mesh: MESH:C102777
 xref: PMID:1368866;   PMID:15322259;   PMID:21428375;   PMID:22759914;   PMID:23513467;   PMID:23866810;   PMID:9535013;   Patent:CN101658517;   Reaxys:5161429



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gamma-mangostin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO [gamma-mangostin co-treated with MK 2206] results in decreased expression of ACTA2 protein; diphenyleneiodonium promotes the reaction [gamma-mangostin results in decreased expression of ACTA2 protein]; gamma-mangostin promotes the reaction [diphenyleneiodonium results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [gamma-mangostin results in decreased expression of ACTA2 protein]
gamma-mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD PMID:30502394 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO [gamma-mangostin co-treated with MK 2206] results in decreased phosphorylation of AKT1 protein
gamma-mangostin results in decreased phosphorylation of AKT1 protein
CTD PMID:30502394 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO gamma-mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30502394 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO gamma-mangostin results in increased expression of HDAC1 protein CTD PMID:30502394 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hmgb1 high mobility group box 1 decreases secretion
multiple interactions
ISO gamma-mangostin results in decreased secretion of HMGB1 protein
diphenyleneiodonium promotes the reaction [gamma-mangostin results in decreased secretion of HMGB1 protein]; gamma-mangostin affects the localization of and results in decreased acetylation of HMGB1 protein; gamma-mangostin promotes the reaction [diphenyleneiodonium results in decreased secretion of HMGB1 protein]; SIRT3 protein affects the reaction [gamma-mangostin results in decreased secretion of HMGB1 protein]
gamma-mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]
CTD PMID:30502394 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
ISO SIRT3 protein affects the reaction [gamma-mangostin results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [gamma-mangostin results in decreased secretion of HMGB1 protein]
[gamma-mangostin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion of SIRT3 protein
gamma-mangostin results in increased expression of SIRT3 protein
CTD PMID:30502394 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            antineoplastic agent 17359
              gamma-mangostin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      ketone 16957
                                        cyclic ketone 15522
                                          xanthones 174
                                            gamma-mangostin 6
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