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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gamma-mangostin
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Accession:CHEBI:67548 term browser browse the term
Definition:A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity.
Synonyms:exact_synonym: 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
 related_synonym: Formula=C23H24O6;   InChI=1S/C23H24O6/c1-11(2)5-7-13-15(24)9-18-20(22(13)27)23(28)19-14(8-6-12(3)4)21(26)16(25)10-17(19)29-18/h5-6,9-10,24-27H,7-8H2,1-4H3;   InChIKey=VEZXFTKZUMARDU-UHFFFAOYSA-N;   SMILES=CC(C)=CCc1c(O)cc2oc3cc(O)c(O)c(CC=C(C)C)c3c(=O)c2c1O
 xref: CAS:31271-07-5;   HMDB:HMDB0035795
 xref_mesh: MESH:C102777
 xref: PMID:1368866;   PMID:15322259;   PMID:21428375;   PMID:22759914;   PMID:23513467;   PMID:23866810;   PMID:9535013;   Patent:CN101658517;   Reaxys:5161429


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gamma-mangostin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO [gamma-mangostin co-treated with MK 2206] results in decreased expression of ACTA2 protein; diphenyleneiodonium promotes the reaction [gamma-mangostin results in decreased expression of ACTA2 protein]; gamma-mangostin promotes the reaction [diphenyleneiodonium results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [gamma-mangostin results in decreased expression of ACTA2 protein]
gamma-mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD PMID:30502394 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO [gamma-mangostin co-treated with MK 2206] results in decreased phosphorylation of AKT1 protein
gamma-mangostin results in decreased phosphorylation of AKT1 protein
CTD PMID:30502394 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO gamma-mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30502394 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO gamma-mangostin results in increased expression of HDAC1 protein CTD PMID:30502394 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hmgb1 high mobility group box 1 decreases secretion
multiple interactions
ISO gamma-mangostin results in decreased secretion of HMGB1 protein
diphenyleneiodonium promotes the reaction [gamma-mangostin results in decreased secretion of HMGB1 protein]; gamma-mangostin affects the localization of and results in decreased acetylation of HMGB1 protein; gamma-mangostin promotes the reaction [diphenyleneiodonium results in decreased secretion of HMGB1 protein]; SIRT3 protein affects the reaction [gamma-mangostin results in decreased secretion of HMGB1 protein]
gamma-mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]
CTD PMID:30502394 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
ISO SIRT3 protein affects the reaction [gamma-mangostin results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [gamma-mangostin results in decreased secretion of HMGB1 protein]
[gamma-mangostin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion of SIRT3 protein
gamma-mangostin results in increased expression of SIRT3 protein
CTD PMID:30502394 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        pharmaceutical 19375
          drug 19375
            antineoplastic agent 17034
              gamma-mangostin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      ketone 16222
                                        cyclic ketone 13938
                                          xanthones 168
                                            gamma-mangostin 6
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