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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-mangostin
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Accession:CHEBI:67547 term browser browse the term
Definition:A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.
Synonyms:exact_synonym: 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
 related_synonym: 1,3,6-trihydroxy-7-methoxy-2,8-diprenylxanthone;   Formula=C24H26O6;   InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3;   InChIKey=GNRIZKKCNOBBMO-UHFFFAOYSA-N;   SMILES=COC1=C(CC=C(C)C)C2=C(OC3=CC(O)=C(CC=C(C)C)C(O)=C3C2=O)C=C1O;   mangostin
 xref: CAS:6147-11-1;   Chemspider:4444969;   FooDB:FDB014546;   HMDB:HMDB0035796;   KEGG:C10080;   KNApSAcK:C00002963
 xref_mesh: MESH:C021053
 xref: PDBeChem:MKS;   PMID:20380307;   PMID:21428375;   PMID:22832848;   PMID:22982495;   PMID:23232053;   PMID:24273861;   PMID:26310724;   PMID:30771603;   Patent:CN101612147;   Patent:CN102670581;   Reaxys:362302;   Wikipedia:Mangostin


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alpha-mangostin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 EXP
ISO		 mangostin results in decreased expression of ACTA2 protein
[mangostin co-treated with MK 2206] results in decreased expression of ACTA2 protein; diphenyleneiodonium promotes the reaction [mangostin results in decreased expression of ACTA2 protein]; mangostin promotes the reaction [diphenyleneiodonium results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [mangostin results in decreased expression of ACTA2 protein]
mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]		 CTD PMID:30502394 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 affects localization EXP mangostin affects the localization of AIFM1 protein CTD PMID:24480042 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 EXP mangostin results in decreased phosphorylation of AKT1 protein
[mangostin co-treated with MK 2206] results in decreased phosphorylation of AKT1 protein		 CTD PMID:23954321 PMID:30502394 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP mangostin results in increased expression of BAX protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 EXP mangostin results in decreased expression of BCL2 protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BID BH3 interacting domain death agonist decreases expression EXP mangostin results in decreased expression of BID protein CTD PMID:24480042 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:26357513 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP7 caspase 7 multiple interactions
increases activity		 EXP ESR1 protein affects the reaction [mangostin results in increased activity of CASP7 protein] CTD PMID:24480042 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 increases activity EXP mangostin results in increased activity of CASP8 protein CTD PMID:24480042 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity EXP mangostin results in increased activity of CASP9 protein CTD PMID:23954321 PMID:24480042 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CYCS cytochrome c, somatic increases expression EXP mangostin results in increased expression of CYCS protein CTD PMID:24480042 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
decreases expression
affects response to substance		 EXP ESR1 protein affects the reaction [mangostin results in increased activity of CASP7 protein]
mangostin results in decreased expression of ESR1 protein
ESR1 protein affects the susceptibility to mangostin		 CTD PMID:24480042 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30502394 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G HDAC1 histone deacetylase 1 increases expression EXP mangostin results in increased expression of HDAC1 protein CTD PMID:30502394 NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635 		JBrowse link
G HMGB1 high mobility group box 1 multiple interactions
decreases secretion		 ISO
EXP		 mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]
mangostin results in decreased secretion of HMGB1 protein
diphenyleneiodonium promotes the reaction [mangostin results in decreased secretion of HMGB1 protein]; mangostin affects the localization of and results in decreased acetylation of HMGB1 protein; mangostin promotes the reaction [diphenyleneiodonium results in decreased secretion of HMGB1 protein]; SIRT3 protein affects the reaction [mangostin results in decreased secretion of HMGB1 protein]		 CTD PMID:30502394 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 increases phosphorylation EXP mangostin analog results in increased phosphorylation of MAP2K1 protein CTD PMID:28722351 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 increases phosphorylation EXP mangostin analog results in increased phosphorylation of MAP2K2 protein CTD PMID:28722351 NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 increases phosphorylation EXP mangostin analog results in increased phosphorylation of MAP2K4 protein CTD PMID:28722351 NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP mangostin results in decreased expression of and results in decreased phosphorylation of MAPK1 protein
mangostin analog results in increased phosphorylation of MAPK1 protein		 CTD PMID:23954321 PMID:28722351 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP mangostin results in decreased expression of and results in decreased phosphorylation of MAPK3 protein
mangostin analog results in increased phosphorylation of MAPK3 protein		 CTD PMID:23954321 PMID:28722351 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP mangostin analog results in increased phosphorylation of MAPK8 protein CTD PMID:28722351 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP mangostin analog results in increased phosphorylation of MAPK9 protein CTD PMID:28722351 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]
mangostin analog results in decreased expression of MMP2 mRNA; mangostin analog results in decreased expression of MMP2 protein		 CTD PMID:28722351 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]
mangostin analog results in decreased expression of MMP9 mRNA; mangostin analog results in decreased expression of MMP9 protein		 CTD PMID:28722351 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP mangostin results in increased cleavage of PARP1 protein CTD PMID:23954321 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO mangostin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein] CTD PMID:18424012 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G SIRT3 sirtuin 3 increases expression
multiple interactions		 EXP
ISO		 mangostin results in increased expression of SIRT3 protein
[mangostin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion of SIRT3 protein
SIRT3 protein affects the reaction [mangostin results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [mangostin results in decreased secretion of HMGB1 protein]		 CTD PMID:30502394 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G TFF1 trefoil factor 1 decreases expression EXP mangostin results in decreased expression of TFF1 protein CTD PMID:24480042 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO mangostin inhibits the reaction [Isoproterenol results in increased expression of TNF protein] CTD PMID:18424012 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions		 EXP mangostin results in increased expression of TP53 protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      chemical role 24242
        antioxidant 17487
          alpha-mangostin 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  oxacycle 19986
                                    dibenzopyran 288
                                      xanthenes 282
                                        xanthones 212
                                          alpha-mangostin 30
paths to the root