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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha-mangostin
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Accession:CHEBI:67547 term browser browse the term
Definition:A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.
Synonyms:exact_synonym: 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
 related_synonym: 1,3,6-trihydroxy-7-methoxy-2,8-diprenylxanthone;   Formula=C24H26O6;   InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3;   InChIKey=GNRIZKKCNOBBMO-UHFFFAOYSA-N;   SMILES=COC1=C(CC=C(C)C)C2=C(OC3=CC(O)=C(CC=C(C)C)C(O)=C3C2=O)C=C1O;   mangostin
 xref: CAS:6147-11-1;   Chemspider:4444969;   FooDB:FDB014546;   HMDB:HMDB0035796;   KEGG:C10080;   KNApSAcK:C00002963
 xref_mesh: MESH:C021053
 xref: PDBeChem:MKS;   PMID:20380307;   PMID:21428375;   PMID:22832848;   PMID:22982495;   PMID:23232053;   PMID:24273861;   PMID:26310724;   PMID:30771603;   Patent:CN101612147;   Patent:CN102670581;   Reaxys:362302;   Wikipedia:Mangostin



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alpha-mangostin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO mangostin affects the localization of AIFM1 protein CTD PMID:24480042 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO mangostin results in decreased phosphorylation of AKT1 protein CTD PMID:23954321 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO mangostin results in increased expression of BAX protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]
CTD PMID:24480042 PMID:26357513 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO mangostin results in decreased expression of BCL2 protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 mRNA]
CTD PMID:24480042 PMID:26357513 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO mangostin results in decreased expression of BID protein CTD PMID:24480042 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 multiple interactions ISO mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:26357513 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO ESR1 protein affects the reaction [mangostin results in increased activity of CASP7 protein] CTD PMID:24480042 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity ISO mangostin results in increased activity of CASP8 protein CTD PMID:24480042 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO mangostin results in increased activity of CASP9 protein CTD PMID:23954321 PMID:24480042 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO mangostin results in increased expression of CYCS protein CTD PMID:24480042 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
affects response to substance
ISO ESR1 protein affects the reaction [mangostin results in increased activity of CASP7 protein]
mangostin results in decreased expression of ESR1 protein
ESR1 protein affects the susceptibility to mangostin
CTD PMID:24480042 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAP2K1 protein CTD PMID:28722351 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAP2K2 protein CTD PMID:28722351 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAP2K4 protein CTD PMID:28722351 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO mangostin results in decreased expression of and results in decreased phosphorylation of MAPK1 protein
mangostin analog results in increased phosphorylation of MAPK1 protein
CTD PMID:23954321 PMID:28722351 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO mangostin results in decreased expression of and results in decreased phosphorylation of MAPK3 protein
mangostin analog results in increased phosphorylation of MAPK3 protein
CTD PMID:23954321 PMID:28722351 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAPK8 protein CTD PMID:28722351 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAPK9 protein CTD PMID:28722351 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]
mangostin analog results in decreased expression of MMP2 mRNA; mangostin analog results in decreased expression of MMP2 protein
CTD PMID:28722351 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO mangostin analog results in decreased expression of MMP9 mRNA; mangostin analog results in decreased expression of MMP9 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]
CTD PMID:28722351 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO mangostin results in increased cleavage of PARP1 protein CTD PMID:23954321 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP mangostin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein] CTD PMID:18424012 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO mangostin results in decreased expression of TFF1 protein CTD PMID:24480042 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP mangostin inhibits the reaction [Isoproterenol results in increased expression of TNF protein] CTD PMID:18424012 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO mangostin results in increased expression of TP53 protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 mRNA]
CTD PMID:24480042 PMID:26357513 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 20056
    role 20008
      chemical role 19544
        antioxidant 15014
          alpha-mangostin 25
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  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      ketone 17091
                                        cyclic ketone 15644
                                          xanthones 175
                                            alpha-mangostin 25
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