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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-mangostin
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Accession:CHEBI:67547 term browser browse the term
Definition:A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.
Synonyms:exact_synonym: 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
 related_synonym: 1,3,6-trihydroxy-7-methoxy-2,8-diprenylxanthone;   Formula=C24H26O6;   InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3;   InChIKey=GNRIZKKCNOBBMO-UHFFFAOYSA-N;   SMILES=COC1=C(CC=C(C)C)C2=C(OC3=CC(O)=C(CC=C(C)C)C(O)=C3C2=O)C=C1O;   mangostin
 xref: CAS:6147-11-1;   Chemspider:4444969;   FooDB:FDB014546;   HMDB:HMDB0035796;   KEGG:C10080;   KNApSAcK:C00002963
 xref_mesh: MESH:C021053
 xref: PDBeChem:MKS;   PMID:20380307;   PMID:21428375;   PMID:22832848;   PMID:22982495;   PMID:23232053;   PMID:24273861;   PMID:26310724;   PMID:30771603;   Patent:CN101612147;   Patent:CN102670581;   Reaxys:362302;   Wikipedia:Mangostin


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alpha-mangostin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 ISO [mangostin co-treated with MK 2206] results in decreased expression of ACTA2 protein; diphenyleneiodonium promotes the reaction [mangostin results in decreased expression of ACTA2 protein]; mangostin promotes the reaction [diphenyleneiodonium results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [mangostin results in decreased expression of ACTA2 protein]
mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]		 CTD PMID:30502394 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO mangostin affects the localization of AIFM1 protein CTD PMID:24480042 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO mangostin results in decreased phosphorylation of AKT1 protein
[mangostin co-treated with MK 2206] results in decreased phosphorylation of AKT1 protein		 CTD PMID:23954321 PMID:30502394 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO mangostin results in increased expression of BAX protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO mangostin results in decreased expression of BCL2 protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO mangostin results in decreased expression of BID protein CTD PMID:24480042 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:26357513 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO ESR1 protein affects the reaction [mangostin results in increased activity of CASP7 protein] CTD PMID:24480042 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity ISO mangostin results in increased activity of CASP8 protein CTD PMID:24480042 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO mangostin results in increased activity of CASP9 protein CTD PMID:23954321 PMID:24480042 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO mangostin results in increased expression of CYCS protein CTD PMID:24480042 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects response to substance
decreases expression		 ISO ESR1 protein affects the reaction [mangostin results in increased activity of CASP7 protein]
ESR1 protein affects the susceptibility to mangostin
mangostin results in decreased expression of ESR1 protein		 CTD PMID:24480042 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30502394 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO mangostin results in increased expression of HDAC1 protein CTD PMID:30502394 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hmgb1 high mobility group box 1 decreases secretion
multiple interactions		 ISO mangostin results in decreased secretion of HMGB1 protein
diphenyleneiodonium promotes the reaction [mangostin results in decreased secretion of HMGB1 protein]; mangostin affects the localization of and results in decreased acetylation of HMGB1 protein; mangostin promotes the reaction [diphenyleneiodonium results in decreased secretion of HMGB1 protein]; SIRT3 protein affects the reaction [mangostin results in decreased secretion of HMGB1 protein]
mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]		 CTD PMID:30502394 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAP2K1 protein CTD PMID:28722351 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAP2K2 protein CTD PMID:28722351 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAP2K4 protein CTD PMID:28722351 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO mangostin results in decreased expression of and results in decreased phosphorylation of MAPK1 protein
mangostin analog results in increased phosphorylation of MAPK1 protein		 CTD PMID:23954321 PMID:28722351 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO mangostin results in decreased expression of and results in decreased phosphorylation of MAPK3 protein
mangostin analog results in increased phosphorylation of MAPK3 protein		 CTD PMID:23954321 PMID:28722351 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAPK8 protein CTD PMID:28722351 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAPK9 protein CTD PMID:28722351 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]
mangostin analog results in decreased expression of MMP2 mRNA; mangostin analog results in decreased expression of MMP2 protein		 CTD PMID:28722351 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO mangostin analog results in decreased expression of MMP9 mRNA; mangostin analog results in decreased expression of MMP9 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]		 CTD PMID:28722351 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO mangostin results in increased cleavage of PARP1 protein CTD PMID:23954321 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP mangostin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein] CTD PMID:18424012 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sirt3 sirtuin 3 increases expression
multiple interactions		 ISO mangostin results in increased expression of SIRT3 protein
[mangostin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion of SIRT3 protein
SIRT3 protein affects the reaction [mangostin results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [mangostin results in decreased secretion of HMGB1 protein]		 CTD PMID:30502394 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO mangostin results in decreased expression of TFF1 protein CTD PMID:24480042 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP mangostin inhibits the reaction [Isoproterenol results in increased expression of TNF protein] CTD PMID:18424012 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO mangostin results in increased expression of TP53 protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
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  CHEBI ontology 19812
    role 19784
      chemical role 19418
        antioxidant 15723
          alpha-mangostin 30
Path 2
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  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic group 18902
                              organic divalent group 18884
                                organodiyl group 18884
                                  carbonyl group 18850
                                    carbonyl compound 18850
                                      ketone 17140
                                        cyclic ketone 15686
                                          xanthones 176
                                            alpha-mangostin 30
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