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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:6754 term browser browse the term
Definition:A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
Synonyms:exact_synonym: ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
 related_synonym: 1-methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester;   1-methyl-4-phenylisonipecotic acid ethyl ester;   1-methyl-4-phenylpiperidine-4-carboxylic acid ethyl ester;   Demerol;   Formula=C15H21NO2;   IDS-NP-001;   InChI=1S/C15H21NO2/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13/h4-8H,3,9-12H2,1-2H3;   InChIKey=XADCESSVHJOZHK-UHFFFAOYSA-N;   N-methyl-4-phenyl-4-carbethoxypiperidine;   Nemerol;   SMILES=C1(C(=O)OCC)(CCN(CC1)C)C2=CC=CC=C2;   ethyl 1-methyl-4-phenylisonipecotate;   isonipecaine;   meperidina;   meperidine;   meperidol;   methyl phenylpiperidine carbonic acid ethyl ester;   pethanol;   pethidin;   pethidineter;   pethidinum;   petidina;   petydyna;   phetidine
 xref: CAS:57-42-1;   DrugBank:DB00454;   Drug_Central:1690;   HMDB:HMDB0014597;   KEGG:C07128;   KEGG:D08343
 xref_mesh: MESH:D008614
 xref: PMID:27621675;   PMID:28666300;   PMID:29880084;   PMID:30115484;   PMID:30362203;   PMID:30386603;   PMID:30418234;   PMID:30487674;   PMID:30786304;   PMID:30902024;   PMID:30902579;   PMID:31001434;   PMID:31294134;   PMID:31319637;   PMID:31423145;   PMID:31486253;   PMID:31633090;   PMID:31874879;   PMID:32001961;   PMID:32214301;   Wikipedia:Pethidine
 cyclic_relationship: is_conjugate_base_of CHEBI:149471

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pethidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D affects binding
increases hydrolysis
ISO Meperidine binds to CES1 protein
CES1 protein results in increased hydrolysis of Meperidine
CTD PMID:10381793 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Meperidine binds to CES2 protein CTD PMID:10381793 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        pharmacological role 19070
          analgesic 14638
            opioid analgesic 656
              pethidine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      chalcogen 19683
                        oxygen atom 19655
                          oxygen molecular entity 19655
                            hydroxides 19380
                              organic hydroxy compound 18898
                                alcohol 15184
                                  primary alcohol 14059
                                    ethanols 8198
                                      ethanol 8198
                                        ethyl ester 3313
                                          pethidine 2
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