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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:6754 term browser browse the term
Definition:A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
Synonyms:exact_synonym: ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
 related_synonym: 1-methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester;   1-methyl-4-phenylisonipecotic acid ethyl ester;   1-methyl-4-phenylpiperidine-4-carboxylic acid ethyl ester;   Demerol;   Formula=C15H21NO2;   IDS-NP-001;   InChI=1S/C15H21NO2/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13/h4-8H,3,9-12H2,1-2H3;   InChIKey=XADCESSVHJOZHK-UHFFFAOYSA-N;   N-methyl-4-phenyl-4-carbethoxypiperidine;   Nemerol;   SMILES=C1(C(=O)OCC)(CCN(CC1)C)C2=CC=CC=C2;   ethyl 1-methyl-4-phenylisonipecotate;   isonipecaine;   meperidina;   meperidine;   meperidol;   methyl phenylpiperidine carbonic acid ethyl ester;   pethanol;   pethidin;   pethidineter;   pethidinum;   petidina;   petydyna;   phetidine
 xref: CAS:57-42-1;   DrugBank:DB00454;   Drug_Central:1690;   HMDB:HMDB0014597;   KEGG:C07128;   KEGG:D08343
 xref_mesh: MESH:D008614
 xref: PMID:27621675;   PMID:28666300;   PMID:29880084;   PMID:30115484;   PMID:30362203;   PMID:30386603;   PMID:30418234;   PMID:30487674;   PMID:30786304;   PMID:30902024;   PMID:30902579;   PMID:31001434;   PMID:31294134;   PMID:31319637;   PMID:31423145;   PMID:31486253;   PMID:31633090;   PMID:31874879;   PMID:32001961;   PMID:32214301;   Wikipedia:Pethidine
 cyclic_relationship: is_conjugate_base_of CHEBI:149471

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pethidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D affects binding
increases hydrolysis
ISO Meperidine binds to CES1 protein
CES1 protein results in increased hydrolysis of Meperidine
CTD PMID:10381793 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Meperidine binds to CES2 protein CTD PMID:10381793 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        pharmacological role 18830
          analgesic 13091
            opioid analgesic 632
              pethidine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      chalcogen 19391
                        oxygen atom 19354
                          oxygen molecular entity 19354
                            hydroxides 19077
                              organic hydroxy compound 18656
                                alcohol 15010
                                  primary alcohol 13914
                                    ethanols 8169
                                      ethanol 8169
                                        ethyl ester 3253
                                          pethidine 2
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