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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mepanipyrim
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Accession:CHEBI:6751 term browser browse the term
Definition:A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying additional methyl and 1-propynyl substituents at positions 4 and 6 respectively. A fungicide used to control a wide range of diseases including grey mould on strawberries, tomatoes and cucumabers, and scab on apples and pears.
Synonyms:related_synonym: 4-methyl-N-phenyl-6-(1-propynyl)-2-pyrimidinamine;   Formula=C14H13N3;   InChI=1S/C14H13N3/c1-3-7-13-10-11(2)15-14(17-13)16-12-8-5-4-6-9-12/h4-6,8-10H,1-2H3,(H,15,16,17);   InChIKey=CIFWZNRJIBNXRE-UHFFFAOYSA-N;   N-(4-Methyl-6-prop-1-ynylpyrimidin-2-yl)aniline;   SMILES=CC#Cc1cc(C)nc(Nc2ccccc2)n1
 xref: CAS:110235-47-7;   KEGG:C10919
 xref_mesh: MESH:C104083
 xref: PMID:12619685;   PMID:21047134;   PMID:22562348;   PMID:23285970;   PMID:23410121;   PMID:23436777;   PMID:23887887;   PMID:24432637;   PMID:8987670;   PMID:9779415;   PMID:9779416;   PMID:9850581;   PMID:9882586;   PPDB:435;   Patent:NZ548020;   Patent:WO2012011287;   Pesticides:mepanipyrim;   Reaxys:8392999



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mepanipyrim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO mepanipyrim binds to and results in increased activity of AHR protein CTD PMID:23436777 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of AIF1 protein
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]
CTD PMID:31939705 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [APP gene mutant form results in increased expression of APP protein modified form] which results in increased susceptibility to mepanipyrim; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein]; APP protein modified form results in increased susceptibility to [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] CTD PMID:31939705 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of BACE1 protein CTD PMID:31939705 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Esr1 estrogen receptor 1 increases activity EXP mepanipyrim results in increased activity of ESR1 protein CTD PMID:33352482 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of GFAP protein
CTD PMID:31939705 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein] CTD PMID:31939705 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein] CTD PMID:31939705 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO mepanipyrim results in increased expression of NRF1 mRNA CTD PMID:33352482 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        aetiopathogenetic role 19275
          hepatotoxic agent 16227
            mepanipyrim 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  organic heteromonocyclic compound 17145
                                    diazines 12356
                                      pyrimidines 12187
                                        pyrimidine antifungal agent 80
                                          pyrimidine fungicide 77
                                            anilinopyrimidine fungicide 30
                                              mepanipyrim 9
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