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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mepanipyrim
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Accession:CHEBI:6751 term browser browse the term
Definition:A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying additional methyl and 1-propynyl substituents at positions 4 and 6 respectively. A fungicide used to control a wide range of diseases including grey mould on strawberries, tomatoes and cucumabers, and scab on apples and pears.
Synonyms:related_synonym: 4-methyl-N-phenyl-6-(1-propynyl)-2-pyrimidinamine;   Formula=C14H13N3;   InChI=1S/C14H13N3/c1-3-7-13-10-11(2)15-14(17-13)16-12-8-5-4-6-9-12/h4-6,8-10H,1-2H3,(H,15,16,17);   InChIKey=CIFWZNRJIBNXRE-UHFFFAOYSA-N;   N-(4-Methyl-6-prop-1-ynylpyrimidin-2-yl)aniline;   SMILES=CC#Cc1cc(C)nc(Nc2ccccc2)n1
 xref: CAS:110235-47-7;   KEGG:C10919
 xref_mesh: MESH:C104083
 xref: PMID:12619685;   PMID:21047134;   PMID:22562348;   PMID:23285970;   PMID:23410121;   PMID:23436777;   PMID:23887887;   PMID:24432637;   PMID:8987670;   PMID:9779415;   PMID:9779416;   PMID:9850581;   PMID:9882586;   PPDB:435;   Patent:NZ548020;   Patent:WO2012011287;   Pesticides:mepanipyrim;   Reaxys:8392999


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mepanipyrim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO mepanipyrim binds to and results in increased activity of AHR protein CTD PMID:23436777 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of AIF1 protein
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]
CTD PMID:31939705 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [APP gene mutant form results in increased expression of APP protein modified form] which results in increased susceptibility to mepanipyrim; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein]; APP protein modified form results in increased susceptibility to [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] CTD PMID:31939705 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of BACE1 protein CTD PMID:31939705 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of GFAP protein
CTD PMID:31939705 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein] CTD PMID:31939705 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein] CTD PMID:31939705 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        aetiopathogenetic role 18937
          hepatotoxic agent 14565
            mepanipyrim 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteromonocyclic compound 16445
                                    diazines 12139
                                      pyrimidines 11956
                                        pyrimidine antifungal agent 70
                                          pyrimidine fungicide 67
                                            anilinopyrimidine fungicide 22
                                              mepanipyrim 7
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