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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:quercetin 3-O-beta-D-galactopyranoside
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Accession:CHEBI:67486 term browser browse the term
Definition:A quercetin O-glycoside that is quercetin with a beta-D-galactosyl residue attached at position 3. Isolated from Artemisia capillaris, it exhibits hepatoprotective activity.
Synonyms:exact_synonym: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl beta-D-galactopyranoside
 related_synonym: 2-(3,4-dihydroxyphenyl)-3-(beta-D-galactopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one;   Formula=C21H20O12;   Hyperin;   Hyperoside;   InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15+,17+,18-,21+/m1/s1;   InChIKey=OVSQVDMCBVZWGM-DTGCRPNFSA-N;   Quercetin 3-galactoside;   SMILES=OC[C@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@H]1O;   quercetin 3-O-galactoside
 alt_id: CHEBI:5836
 xref: CAS:482-36-0;   HMDB:HMDB0030775;   KEGG:C10073;   KNApSAcK:C00005372;   LINCS:LSM-5907;   LIPID_MAPS_instance:LMPK12112041
 xref_mesh: MESH:C021304
 xref: PMID:21428416;   PMID:22324400;   PMID:23220618;   PMID:23291593;   PMID:23835282;   PMID:24173369;   Reaxys:100990;   Wikipedia:Hyperoside


show annotations for term's descendants           Sort by:
quercetin 3-O-beta-D-galactopyranoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases expression
multiple interactions 		EXP hyperoside results in increased expression of ACHE mRNA
hyperoside results in increased expression of and results in increased activity of ACHE protein 		CTD PMID:27019979 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in increased cleavage of ATF6 protein] CTD PMID:38848825 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP 		hyperoside inhibits the reaction [Particulate Matter results in increased expression of BAX protein]; hyperoside inhibits the reaction [tert-Butylhydroperoxide affects the localization of BAX protein]
hyperoside inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein] 		CTD PMID:18552516 PMID:31326407 PMID:38848825 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP hyperoside inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:31326407 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in increased expression of BCL2L11 protein] CTD PMID:38848825 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Quercetin co-treated with hyperoside] results in decreased expression of BIRC5 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of BIRC5 protein CTD PMID:24173369 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Quercetin co-treated with hyperoside] results in increased cleavage of CASP3 protein CTD PMID:24173369 PMID:25354548 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP cyclopamine inhibits the reaction [hyperoside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]]; hyperoside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein] CTD PMID:31326407 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in decreased expression of CCND1 protein] CTD PMID:38848825 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in decreased expression of CCNE1 protein] CTD PMID:38848825 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in decreased expression of CDK2 protein] CTD PMID:38848825 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in decreased expression of CDK4 protein] CTD PMID:38848825 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in increased expression of CDKN1A protein] CTD PMID:38848825 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in increased expression of CDKN2A protein] CTD PMID:38848825 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO hyperoside inhibits the reaction [tert-Butylhydroperoxide affects the localization of CYCS protein] CTD PMID:18552516 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions 		ISO hyperoside results in decreased activity of CYP2E1 protein
hyperoside inhibits the reaction [Acetaminophen results in decreased activity of CYP2E1 protein] 		CTD PMID:26772156 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in increased expression of DDIT3 protein] CTD PMID:38848825 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in increased phosphorylation of EIF2AK3 protein] CTD PMID:38848825 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in increased phosphorylation of EIF2S1 protein] CTD PMID:38848825 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in increased phosphorylation of ERN1 protein] CTD PMID:38848825 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO hyperoside inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:22613215 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions
increases expression 		EXP hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of GLI1 mRNA]; hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of GLI1 protein]
hyperoside results in increased expression of GLI1 mRNA; hyperoside results in increased expression of GLI1 protein 		CTD PMID:31326407 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO hyperoside inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:26772156 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in increased expression of HSPA5 protein] CTD PMID:38848825 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein] CTD PMID:30125551 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:30125551 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in decreased expression of MCL1 protein] CTD PMID:38848825 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mir21 microRNA 21 multiple interactions ISO [Quercetin co-treated with hyperoside] results in decreased expression of MIR21 mRNA; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA]; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein]; MIR21 mRNA results in decreased susceptibility to [Quercetin co-treated with hyperoside] CTD PMID:25354548 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir27a microRNA 27a multiple interactions ISO [Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in decreased expression of ZBTB10 mRNA]; [Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in increased expression of SP1 mRNA]; [Quercetin co-treated with hyperoside] results in decreased expression of MIR27A mRNA; MIR27A mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of ZBTB10 mRNA] CTD PMID:24173369 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in increased expression of MMP1 protein] CTD PMID:38848825 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO hyperoside inhibits the reaction [Particulate Matter results in increased expression of MMP9 protein] CTD PMID:38848825 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO hyperoside affects the localization of NFE2L2 protein CTD PMID:26772156 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:30125551 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Hyperoside increases expression of Nqo1 protein in liver RGD PMID:31399183 RGD:25823190 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Quercetin co-treated with hyperoside] results in increased cleavage of PARP1 protein CTD PMID:24173369 PMID:25354548 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdcd4 programmed cell death 4 multiple interactions ISO [Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA; [Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA]; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein] CTD PMID:25354548 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Prima1 proline rich membrane anchor 1 increases expression EXP hyperoside results in increased expression of PRIMA1 mRNA CTD PMID:27019979 NCBI chr 6:128,094,686...128,155,592
Ensembl chr 6:122,338,370...122,389,921 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] CTD PMID:30125551 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Shh sonic hedgehog signaling molecule increases expression
multiple interactions 		EXP hyperoside results in increased expression of SHH mRNA; hyperoside results in increased expression of SHH protein
hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SHH mRNA]; hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SHH protein] 		CTD PMID:31326407 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO hyperoside inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SIRT1 protein] CTD PMID:18552516 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression ISO hyperoside analog results in increased expression of SLC2A2 mRNA CTD PMID:33493636 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Slc5a1 solute carrier family 5 member 1 increases expression ISO hyperoside analog results in increased expression of SLC5A1 mRNA CTD PMID:33493636 NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547 		JBrowse link
G Smo smoothened, frizzled class receptor increases expression
multiple interactions 		EXP hyperoside results in increased expression of SMO mRNA; hyperoside results in increased expression of SMO protein
hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO mRNA]; hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO protein] 		CTD PMID:31326407 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in increased expression of SP1 mRNA]; [Quercetin co-treated with hyperoside] results in decreased expression of SP1 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of SP1 protein CTD PMID:24173369 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sp3 Sp3 transcription factor multiple interactions ISO [Quercetin co-treated with hyperoside] results in decreased expression of SP3 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of SP3 protein CTD PMID:24173369 NCBI chr 3:78,219,421...78,272,318
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
G Sp4 Sp4 transcription factor multiple interactions ISO [Quercetin co-treated with hyperoside] results in decreased expression of SP4 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of SP4 protein CTD PMID:24173369 NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions
increases expression 		ISO hyperoside inhibits the reaction [Acetaminophen results in decreased expression of SULT2A1 mRNA]
hyperoside results in increased expression of SULT2A1 mRNA 		CTD PMID:26772156 NCBI chr 1:84,582,011...84,639,001
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO hyperoside inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]; hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] CTD PMID:30125551 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO hyperoside inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein] CTD PMID:30125551 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases expression 		ISO hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A1 mRNA]
hyperoside results in increased expression of UGT1A1 mRNA 		CTD PMID:26772156 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A6 mRNA] CTD PMID:26772156 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions
increases expression 		ISO hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT2B1 mRNA]
hyperoside results in increased expression of UGT2B1 mRNA 		CTD PMID:26772156 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:30125551 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Zbtb10 zinc finger and BTB domain containing 10 multiple interactions ISO [Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in decreased expression of ZBTB10 mRNA]; [Quercetin co-treated with hyperoside] results in increased expression of ZBTB10 mRNA; MIR27A mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of ZBTB10 mRNA] CTD PMID:24173369 NCBI chr 2:94,382,670...94,417,308
Ensembl chr 2:92,479,014...92,512,515 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        epitope 7055
          beta-D-galactose 57
            beta-D-galactoside 57
              quercetin 3-O-beta-D-galactopyranoside 54
                quercetin 3-(6''-p-hydroxybenzoylgalactoside) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            organic molecule 20649
                              organic cyclic compound 20400
                                organic heterocyclic compound 19383
                                  oxacycle 18292
                                    benzopyran 12079
                                      1-benzopyran 11825
                                        flavonoid 7283
                                          anthoxanthin 4619
                                            flavones 4619
                                              hydroxyflavone 4596
                                                flavonols 4464
                                                  7-hydroxyflavonol 4429
                                                    quercetin 4365
                                                      quercetin O-glycoside 490
                                                        quercetin 3-O-beta-D-galactopyranoside 54
                                                          quercetin 3-(6''-p-hydroxybenzoylgalactoside) 0
paths to the root