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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:meloxicam
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Accession:CHEBI:6741 term browser browse the term
Definition:A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.
Synonyms:exact_synonym: 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
 related_synonym: Formula=C14H13N3O4S2;   InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19);   InChIKey=ZRVUJXDFFKFLMG-UHFFFAOYSA-N;   Mobic;   SMILES=CN1C(C(=O)Nc2ncc(C)s2)=C(O)c2ccccc2S1(=O)=O;   UNII-VG2QF83CGL;   meloxicamum
 xref: CAS:71125-38-7;   DrugBank:DB00814;   Drug_Central:1676;   HMDB:HMDB0014952;   KEGG:C08169;   KEGG:D00969
 xref_mesh: MESH:C065757
 xref: PMID:10092958;   PMID:12387696;   PMID:16197363;   PMID:16623613;   PMID:16863437;   PMID:18405470;   PMID:19821429;   PMID:23306395;   PMID:23388116;   PMID:23406022;   PMID:24041211;   PMID:24084190;   PMID:28166217;   PMID:8882380;   PMID:9219316;   Patent:DE2756113;   Patent:US4233299;   Reaxys:5886369;   VSDB:1751


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meloxicam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Meloxicam inhibits the reaction [Doxorubicin results in increased activity of ABCB1 protein]; Meloxicam inhibits the reaction [Doxorubicin results in increased expression of ABCB1 protein] CTD PMID:15501994 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects binding ISO ABCC4 protein binds to meloxicam CTD PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO meloxicam inhibits the reaction [Aluminum results in increased expression of APP protein] CTD PMID:16928369 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO meloxicam results in increased expression of BAX protein CTD PMID:19709125 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions EXP meloxicam inhibits the reaction [KNG1 protein binds to and results in increased activity of BDKRB1 protein] CTD PMID:11159707 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
meloxicam results in increased activity of CASP3 protein
Meloxicam inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]
[Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Meloxicam affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Meloxicam inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]
CTD PMID:19709125 PMID:24799355 PMID:29315975 PMID:29484840 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Meloxicam inhibits the reaction [Diquat results in increased expression of CASP9 protein modified form] CTD PMID:29484840 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO meloxicam inhibits the reaction [Doxorubicin results in decreased activity of CAT protein] CTD PMID:24799355 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO meloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein] CTD PMID:16928369 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of and results in increased susceptibility to Meloxicam] which results in increased chemical synthesis of Pyruvaldehyde; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to Meloxicam CTD PMID:33253783 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Ereg epiregulin multiple interactions ISO [meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased expression of EREG mRNA] CTD PMID:22583689 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO meloxicam inhibits the reaction [Paraquat results in decreased expression of GCLC protein] CTD PMID:20851755 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of IL1B protein]; Meloxicam affects the reaction [Formaldehyde affects the expression of IL1B protein] CTD PMID:29315975 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO meloxicam inhibits the reaction [Doxorubicin results in increased expression of IL6 protein] CTD PMID:24799355 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP meloxicam inhibits the reaction [KNG1 protein binds to and results in increased activity of BDKRB1 protein] CTD PMID:11159707 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO meloxicam inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein] CTD PMID:20851755 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO meloxicam inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]] CTD PMID:20851755 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO meloxicam results in decreased expression of PCNA protein CTD PMID:19709125 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
decreases activity
multiple interactions
ISO
EXP
meloxicam results in increased expression of PTGS2 protein
meloxicam results in decreased activity of PTGS2 protein
Meloxicam inhibits the reaction [Diquat results in increased expression of PTGS2 protein]; Meloxicam inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]
[meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased chemical synthesis of Dinoprost]; [meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased expression of EREG mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 protein]
[meloxicam results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [meloxicam results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Chlorpyrifos
CTD PMID:10791687 PMID:11159707 PMID:12417326 PMID:16928369 PMID:17164136 More... NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Meloxicam results in decreased activity of SCN5A protein CTD PMID:33617802 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Sell selectin L affects expression ISO meloxicam affects the expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO [Rutin co-treated with Meloxicam] inhibits the reaction [Formaldehyde affects the activity of SORD protein]; Meloxicam inhibits the reaction [Formaldehyde affects the activity of SORD protein] CTD PMID:29315975 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO meloxicam inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:24799355 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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  CHEBI ontology 19821
    role 19769
      biological role 19769
        pharmacological role 18847
          analgesic 13302
            meloxicam 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                monocarboxylic acid amide 15008
                                                  meloxicam 23
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