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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:meloxicam
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Accession:CHEBI:6741 term browser browse the term
Definition:A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.
Synonyms:exact_synonym: 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
 related_synonym: Formula=C14H13N3O4S2;   InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19);   InChIKey=ZRVUJXDFFKFLMG-UHFFFAOYSA-N;   Mobic;   SMILES=CN1C(C(=O)Nc2ncc(C)s2)=C(O)c2ccccc2S1(=O)=O;   UNII-VG2QF83CGL;   meloxicamum
 xref: CAS:71125-38-7;   DrugBank:DB00814;   Drug_Central:1676;   HMDB:HMDB0014952;   KEGG:C08169;   KEGG:D00969
 xref_mesh: MESH:C065757
 xref: PMID:10092958;   PMID:12387696;   PMID:16197363;   PMID:16623613;   PMID:16863437;   PMID:18405470;   PMID:19821429;   PMID:23306395;   PMID:23388116;   PMID:23406022;   PMID:24041211;   PMID:24084190;   PMID:28166217;   PMID:8882380;   PMID:9219316;   Patent:DE2756113;   Patent:US4233299;   Reaxys:5886369;   VSDB:1751


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meloxicam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Meloxicam inhibits the reaction [Doxorubicin results in increased activity of ABCB1 protein]; Meloxicam inhibits the reaction [Doxorubicin results in increased expression of ABCB1 protein] CTD PMID:15501994 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects binding ISO ABCC4 protein binds to meloxicam CTD PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO meloxicam inhibits the reaction [Aluminum results in increased expression of APP protein] CTD PMID:16928369 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO meloxicam results in increased expression of BAX protein CTD PMID:19709125 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions EXP meloxicam inhibits the reaction [KNG1 protein binds to and results in increased activity of BDKRB1 protein] CTD PMID:11159707 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
meloxicam results in increased activity of CASP3 protein
Meloxicam inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]
[Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Meloxicam affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Meloxicam inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]
CTD PMID:19709125, PMID:24799355, PMID:29315975, PMID:29484840 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Meloxicam inhibits the reaction [Diquat results in increased expression of CASP9 protein modified form] CTD PMID:29484840 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO meloxicam inhibits the reaction [Doxorubicin results in decreased activity of CAT protein] CTD PMID:24799355 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO meloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein] CTD PMID:16928369 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Ereg epiregulin multiple interactions ISO [meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased expression of EREG mRNA] CTD PMID:22583689 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO meloxicam inhibits the reaction [Paraquat results in decreased expression of GCLC protein] CTD PMID:20851755 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of IL1B protein]; Meloxicam affects the reaction [Formaldehyde affects the expression of IL1B protein] CTD PMID:29315975 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO meloxicam inhibits the reaction [Doxorubicin results in increased expression of IL6 protein] CTD PMID:24799355 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP meloxicam inhibits the reaction [KNG1 protein binds to and results in increased activity of BDKRB1 protein] CTD PMID:11159707 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO meloxicam inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein] CTD PMID:20851755 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO meloxicam inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]] CTD PMID:20851755 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO meloxicam results in decreased expression of PCNA protein CTD PMID:19709125 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
decreases activity
multiple interactions
ISO
EXP
meloxicam results in increased expression of PTGS2 protein
meloxicam results in decreased activity of PTGS2 protein
Meloxicam inhibits the reaction [Diquat results in increased expression of PTGS2 protein]; Meloxicam inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]
[meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased chemical synthesis of Dinoprost]; [meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased expression of EREG mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 protein]
[meloxicam results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [meloxicam results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Chlorpyrifos
CTD PMID:10791687, PMID:11159707, PMID:12417326, PMID:16928369, PMID:17164136, PMID:18202791, PMID:22583689, PMID:23416140, PMID:29484840 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sell selectin L affects expression ISO meloxicam affects the expression of SELL protein CTD PMID:12147693 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO [Rutin co-treated with Meloxicam] inhibits the reaction [Formaldehyde affects the activity of SORD protein]; Meloxicam inhibits the reaction [Formaldehyde affects the activity of SORD protein] CTD PMID:29315975 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO meloxicam inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:24799355 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          analgesic 13063
            meloxicam 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  meloxicam 21
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.