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ONTOLOGY REPORT - ANNOTATIONS


Term:meloxicam
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Accession:CHEBI:6741 term browser browse the term
Definition:A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.
Synonyms:exact_synonym: 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
 related_synonym: Formula=C14H13N3O4S2;   InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19);   InChIKey=ZRVUJXDFFKFLMG-UHFFFAOYSA-N;   Mobic;   SMILES=CN1C(C(=O)Nc2ncc(C)s2)=C(O)c2ccccc2S1(=O)=O;   UNII-VG2QF83CGL;   meloxicamum
 xref: CAS:71125-38-7 "KEGG COMPOUND";   DrugBank:DB00814;   Drug_Central:1676 "DrugCentral";   HMDB:HMDB0014952;   KEGG:C08169;   KEGG:D00969
 xref_mesh: MESH:C065757
 xref: PMID:10092958 "Europe PMC";   PMID:12387696 "Europe PMC";   PMID:16197363 "Europe PMC";   PMID:16623613 "Europe PMC";   PMID:16863437 "Europe PMC";   PMID:18405470 "Europe PMC";   PMID:19821429 "Europe PMC";   PMID:23306395 "Europe PMC";   PMID:23388116 "Europe PMC";   PMID:23406022 "Europe PMC";   PMID:24041211 "Europe PMC";   PMID:24084190 "Europe PMC";   PMID:28166217 "Europe PMC";   PMID:8882380 "Europe PMC";   PMID:9219316 "Europe PMC";   Patent:DE2756113;   Patent:US4233299;   Reaxys:5886369 "Reaxys";   VSDB:1751


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meloxicam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Chat choline O-acetyltransferase JBrowse link 16 8,576,858 8,686,131 RGD:6480464
G Ereg epiregulin JBrowse link 14 18,577,620 18,591,395 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Sell selectin L JBrowse link 13 82,369,820 82,387,774 RGD:6480464
G Sord sorbitol dehydrogenase JBrowse link 3 114,176,127 114,207,368 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          analgesic 13037
            meloxicam 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                monocarboxylic acid amide 13180
                                                  meloxicam 21
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.