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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Melarsoprol
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Accession:CHEBI:6729 term browser browse the term
Definition:A triazine that has formula C12H15AsN6OS2.
Synonyms:related_synonym: Formula=C12H15AsN6OS2;   InChI=1S/C12H15AsN6OS2/c14-10-17-11(15)19-12(18-10)16-8-3-1-7(2-4-8)13-21-6-9(5-20)22-13/h1-4,9,20H,5-6H2,(H5,14,15,16,17,18,19);   InChIKey=JCYZMTMYPZHVBF-UHFFFAOYSA-N;   SMILES=Nc1nc(N)nc(Nc2ccc(cc2)[As]2SCC(CO)S2)n1;   arsobal;   melarsaprol;   melarsen B
 xref: CAS:494-79-1;   Drug_Central:3336;   KEGG:C08001;   KEGG:D00832
 xref_mesh: MESH:D008549



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Melarsoprol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Melarsoprol results in decreased expression of BCL2 mRNA; Melarsoprol results in decreased expression of BCL2 protein CTD PMID:9226155 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity ISO Melarsoprol results in increased activity of CASP3 protein CTD PMID:15314284 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Melarsoprol results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Melarsoprol results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Melarsoprol results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Melarsoprol inhibits the reaction [RELA protein binds to NFKB1 protein] CTD PMID:15314284 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Melarsoprol results in increased cleavage of PARP1 protein CTD PMID:15314284 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Melarsoprol inhibits the reaction [RELA protein binds to NFKB1 protein] CTD PMID:15314284 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO Melarsoprol results in decreased expression of and results in increased cleavage of RIPK1 protein CTD PMID:15314284 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    chemical entity 20088
      atom 20058
        nonmetal atom 19979
          nitrogen atom 18963
            nitrogen molecular entity 18937
              organonitrogen compound 18736
                organonitrogen heterocyclic compound 17766
                  triazines 4184
                    Melarsoprol 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  heteroarene 16628
                                    azaarene 5397
                                      triazines 4184
                                        Melarsoprol 9
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