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ONTOLOGY REPORT - ANNOTATIONS


Term:azadiradione
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Accession:CHEBI:67280 term browser browse the term
Definition:A tetracyclic triterpenoid that is 4,4,8-trimethylandrosta-1,14-diene substituted by oxo groups at positions 3 and 16, an acetoxy group at position 7 and a furan-3-yl group at position 17. Isolated from Azadirachta indica, it exhibits antimycobacterial and anti-inflammatory activities.
Synonyms:exact_synonym: (5alpha,7alpha,13alpha,17alpha)-17-(furan-3-yl)-4,4,8-trimethyl-3,16-dioxoandrosta-1,14-dien-7-yl acetate
 related_synonym: 24-Nor-5alpha,13alpha,17alpha-chola-1,14,20,22-tetraene-3,16-dione, 21,23-epoxy-7alpha-hydroxy-4,4,8-trimethyl-,acetate;   Formula=C28H34O5;   InChI=1S/C28H34O5/c1-16(29)33-23-14-20-25(2,3)22(31)8-11-26(20,4)19-7-10-27(5)21(28(19,23)6)13-18(30)24(27)17-9-12-32-15-17/h8-9,11-13,15,19-20,23-24H,7,10,14H2,1-6H3/t19-,20+,23-,24-,26-,27-,28-/m1/s1;   InChIKey=KWAMDQVQFVBEAU-HMWIRDDCSA-N;   SMILES=CC(=O)O[C@@H]1C[C@H]2C(C)(C)C(=O)C=C[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C(=O)C=C3[C@]12C)c1ccoc1
 xref: CAS:26241-51-0
 xref_mesh: MESH:C479321
 xref: PMID:12713364;   PMID:1593280;   PMID:18617378;   PMID:19475987;   PMID:22928548;   Reaxys:5858436


show annotations for term's descendants       view all columns           Sort by:
 
azadiradione term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp8 caspase 8 JBrowse link 1 58,795,233 58,847,503 RGD:6480464
G Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6480464
G Hspa1a heat shock protein 1A JBrowse link 17 34,969,359 34,972,156 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21309
    role 21296
      application 20756
        anti-inflammatory agent 15408
          azadiradione 4
            15-hydroxyazadiradione 0
            17-hydroxyazadiradione 0
            desfuranoazadiradione 0
            epoxyazadiradione + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21309
    subatomic particle 21305
      composite particle 21305
        hadron 21305
          baryon 21305
            nucleon 21305
              atomic nucleus 21305
                atom 21305
                  main group element atom 21181
                    p-block element atom 21181
                      carbon group element atom 20978
                        carbon atom 20869
                          organic molecular entity 20869
                            organic group 19215
                              organic divalent group 19205
                                organodiyl group 19205
                                  carbonyl group 19178
                                    carbonyl compound 19178
                                      ketone 16334
                                        cyclic ketone 13642
                                          alicyclic ketone 1050
                                            cyclic terpene ketone 134
                                              azadiradione 4
                                                15-hydroxyazadiradione 0
                                                17-hydroxyazadiradione 0
                                                desfuranoazadiradione 0
                                                epoxyazadiradione + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.