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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:MK-2206
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Accession:CHEBI:67271 term browser browse the term
Definition:An organic heterotricyclic compound that is [1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one substituted at positions 8 and 9 respectively by 4-(1-aminocyclobutyl)phenyl and phenyl groups.
Synonyms:exact_synonym: 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one
 related_synonym: Formula=C25H21N5O;   InChI=1S/C25H21N5O/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31);   InChIKey=ULDXWLCXEDXJGE-UHFFFAOYSA-N;   SMILES=NC1(CCC1)c1ccc(cc1)-c1nc2ccn3c(n[nH]c3=O)c2cc1-c1ccccc1
 xref: LINCS:LSM-1057
 xref_mesh: MESH:C548887
 xref: Reaxys:18391321


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MK-2206 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 ISO [mangostin co-treated with MK 2206] results in decreased expression of ACTA2 protein; MK 2206 inhibits the reaction [Radon results in increased expression of ACTA2 protein]
MK 2206 results in decreased expression of ACTA2 protein		 CTD PMID:30502394 PMID:32949624 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions ISO MK 2206 inhibits the reaction [AGT protein modified form results in increased secretion of IL6 protein]; MK 2206 inhibits the reaction [AGT protein modified form results in increased secretion of TNF protein] CTD PMID:30354818 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
increases phosphorylation		 ISO
EXP		 MK 2206 results in decreased phosphorylation of AKT1 protein
icariin inhibits the reaction [MK 2206 results in decreased phosphorylation of AKT1 protein]; LEPR affects the reaction [MK 2206 results in decreased phosphorylation of AKT1 protein]
MK 2206 inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of and results in increased expression of AKT1 protein]; MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]
[mangostin co-treated with MK 2206] results in decreased phosphorylation of AKT1 protein; [mirdametinib co-treated with MK 2206] results in increased phosphorylation of AKT1 protein; MK 2206 inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of AKT1 protein]; MK 2206 inhibits the reaction [PNPLA2 protein results in increased phosphorylation of AKT1 protein]; MK 2206 inhibits the reaction [TMED3 protein results in increased phosphorylation of AKT1 protein]; MK 2206 results in decreased phosphorylation of and results in decreased activity of AKT1 protein; romidepsin inhibits the reaction [[mirdametinib co-treated with MK 2206] results in increased phosphorylation of AKT1 protein]
MK 2206 results in increased phosphorylation of AKT1 protein		 CTD PMID:22885370 PMID:22949526 PMID:24685774 PMID:25597859 PMID:27634878 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt1s1 AKT1 substrate 1 decreases phosphorylation
multiple interactions		 ISO MK 2206 results in decreased phosphorylation of AKT1S1 protein
[STO 609 co-treated with MK 2206] results in decreased phosphorylation of AKT1S1 protein		 CTD PMID:28634229 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO MK 2206 inhibits the reaction [Cadmium Chloride results in increased expression of ATF4] CTD PMID:24057571 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO
EXP		 MK 2206 inhibits the reaction [Dexamethasone results in increased phosphorylation of BAD protein]
[MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of BAD protein		 CTD PMID:30878453 PMID:36049518 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [mirdametinib co-treated with MK 2206] results in increased expression of BAK1 protein; [romidepsin co-treated with mirdametinib co-treated with MK 2206] results in increased expression of BAK1 protein; [romidepsin co-treated with MK 2206] results in increased expression of BAK1 protein CTD PMID:27634878 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; MK 2206 inhibits the reaction [Estradiol results in decreased expression of BAX protein] CTD PMID:34724321 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; MK 2206 inhibits the reaction [Estradiol results in increased expression of BCL2 protein] CTD PMID:34724321 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO [mirdametinib co-treated with MK 2206] results in increased expression of BCL2L11 protein; [romidepsin co-treated with mirdametinib co-treated with MK 2206] results in increased expression of BCL2L11 protein; [romidepsin co-treated with MK 2206] results in increased expression of BCL2L11 protein CTD PMID:27634878 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [mirdametinib co-treated with MK 2206] results in increased expression of BID mRNA; [mirdametinib co-treated with MK 2206] results in increased expression of BID protein modified form CTD PMID:28691888 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with MK 2206] results in increased ubiquitination of BIRC5 protein; MK 2206 inhibits the reaction [Epirubicin results in increased expression of BIRC5 protein] CTD PMID:35872041 PMID:36807944 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO MK 2206 results in increased cleavage of CASP3 protein
[MK 2206 co-treated with platycodin D] results in increased activity of CASP3 protein; ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; MK 2206 inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]; MK 2206 inhibits the reaction [Soot analog results in increased expression of CASP3 protein]
MK 2206 inhibits the reaction [Dexamethasone results in increased cleavage of CASP3 protein]		 CTD PMID:22885370 PMID:27897231 PMID:30240709 PMID:30878453 PMID:34724321 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [MK 2206 co-treated with platycodin D] results in increased activity of CASP7 protein CTD PMID:27897231 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP		 MK 2206 inhibits the reaction [Soot analog results in increased expression of CASP9 protein]
[MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CASP9 protein		 CTD PMID:30240709 PMID:36049518 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO MK 2206 inhibits the reaction [cyanoginosin LR results in increased expression of CCND1 protein] CTD PMID:36115647 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd80 Cd80 molecule multiple interactions
decreases expression		 ISO MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of CD80 protein]
MK 2206 results in decreased expression of CD80 protein		 CTD PMID:34398343 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule decreases expression
multiple interactions		 ISO MK 2206 results in decreased expression of CD86 protein
MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of CD86 protein]		 CTD PMID:34398343 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression		 ISO [MK 2206 co-treated with U 0126] results in increased expression of CDH1 mRNA
MK 2206 results in increased expression of CDH1 mRNA
MK 2206 inhibits the reaction [Particulate Matter results in decreased expression of CDH1 protein]; MK 2206 inhibits the reaction [Radon results in decreased expression of CDH1 protein]		 CTD PMID:30723155 PMID:32687961 PMID:32949624 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO MK 2206 inhibits the reaction [Radon results in increased expression of CDH2 protein] CTD PMID:32949624 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
multiple interactions		 ISO MK 2206 results in decreased expression of CEBPA protein
MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of CEBPA protein]		 CTD PMID:34398343 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO MK 2206 inhibits the reaction [Endrin results in increased expression of CEBPD mRNA] CTD PMID:34801515 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions		 ISO MK 2206 results in decreased phosphorylation of CREB1 protein
icariin inhibits the reaction [MK 2206 results in decreased phosphorylation of CREB1 protein]		 CTD PMID:35259346 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO MK 2206 inhibits the reaction [FAM83A protein results in increased expression of CTNNB1 protein]; MK 2206 inhibits the reaction [TMED3 protein results in increased expression of CTNNB1 protein] CTD PMID:34758370 PMID:34931434 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO [MK 2206 co-treated with icariin] results in increased expression of CYP11A1 mRNA; icariin inhibits the reaction [MK 2206 results in decreased expression of CYP11A1 protein] CTD PMID:35259346 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases expression		 ISO MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of EDN1 protein]
MK 2206 results in decreased expression of EDN1 protein		 CTD PMID:34398343 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions
increases expression		 ISO MK 2206 inhibits the reaction [RARRES2 protein results in decreased expression of EDNRB protein modified form]
MK 2206 results in increased expression of EDNRB protein		 CTD PMID:34398343 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Egfr epidermal growth factor receptor increases expression
multiple interactions		 ISO MK 2206 results in increased expression of EGFR protein
platycodin D inhibits the reaction [MK 2206 results in increased expression of EGFR protein]		 CTD PMID:27897231 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions		 ISO MK 2206 results in decreased phosphorylation of EIF4EBP1 protein
[platycodin D co-treated with MK 2206] results in decreased phosphorylation of EIF4EBP1 protein; MK 2206 inhibits the reaction [Epirubicin results in increased phosphorylation of EIF4EBP1 protein]		 CTD PMID:22885370 PMID:27897231 PMID:35872041 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
increases expression		 ISO platycodin D inhibits the reaction [MK 2206 results in increased expression of ERBB2 protein] CTD PMID:27897231 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO MK 2206 promotes the reaction [Cadmium Chloride results in increased expression of ERN1 protein] CTD PMID:29444456 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in increased expression of BCL2 protein]] CTD PMID:34724321 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO MK 2206 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fam83a family with sequence similarity 83, member A multiple interactions ISO MK 2206 inhibits the reaction [FAM83A protein results in increased expression of CTNNB1 protein]; MK 2206 inhibits the reaction [FAM83A protein results in increased phosphorylation of GSK3B protein] CTD PMID:34931434 NCBI chr 7:89,522,826...89,547,284
Ensembl chr 7:89,522,826...89,547,388 		JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO MK 2206 affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP [MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of FGF2 protein CTD PMID:36049518 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression
multiple interactions		 ISO MK 2206 results in decreased expression of FLT1 protein modified form
MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of FLT1 protein modified form]		 CTD PMID:34398343 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO		 MK 2206 inhibits the reaction [Diethylhexyl Phthalate results in increased expression of FN1 protein]
[MK 2206 co-treated with U 0126] results in decreased expression of FN1 mRNA
MK 2206 inhibits the reaction [Radon results in increased expression of FN1 protein]		 CTD PMID:29669060 PMID:30723155 PMID:32949624 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP
ISO		 MK 2206 inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of GSK3B protein]; MK 2206 promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased phosphorylation of GSK3B protein]]
MK 2206 inhibits the reaction [cyanoginosin LR results in increased expression of and results in increased phosphorylation of GSK3B protein]; MK 2206 inhibits the reaction [FAM83A protein results in increased phosphorylation of GSK3B protein]; MK 2206 inhibits the reaction [TMED3 protein results in increased phosphorylation of GSK3B protein]		 CTD PMID:29669060 PMID:34351043 PMID:34758370 PMID:34931434 PMID:36115647 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]] CTD PMID:25597859 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases secretion		 ISO MK 2206 inhibits the reaction [RARRES2 protein results in decreased secretion of IL10 protein]
MK 2206 results in increased secretion of IL10 protein		 CTD PMID:34398343 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO MK 2206 inhibits the reaction [RARRES2 protein results in increased secretion of [IL12A protein binds to IL12B protein]]; MK 2206 results in decreased secretion of [IL12A protein binds to IL12B protein] CTD PMID:34398343 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO MK 2206 inhibits the reaction [RARRES2 protein results in increased secretion of [IL12A protein binds to IL12B protein]]; MK 2206 results in decreased secretion of [IL12A protein binds to IL12B protein] CTD PMID:34398343 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 MK 2206 inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; MK 2206 inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]
MK 2206 promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein]]		 CTD PMID:31018152 PMID:32687961 PMID:34351043 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion		 ISO
EXP		 MK 2206 inhibits the reaction [AGT protein modified form results in increased secretion of IL6 protein]; MK 2206 inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; MK 2206 inhibits the reaction [RARRES2 protein results in increased secretion of IL6 protein]
MK 2206 promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL6 protein]]
MK 2206 results in decreased secretion of IL6 protein		 CTD PMID:30354818 PMID:32687961 PMID:34351043 PMID:34398343 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO MK 2206 inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:22949526 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Irf8 interferon regulatory factor 8 decreases expression
multiple interactions		 ISO MK 2206 results in decreased expression of IRF8 protein
MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of IRF8 protein]		 CTD PMID:34398343 NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP [MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of KDR protein CTD PMID:36049518 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lep leptin multiple interactions ISO MK 2206 inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein] CTD PMID:27381457 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor multiple interactions ISO LEPR affects the reaction [MK 2206 results in decreased phosphorylation of AKT1 protein] CTD PMID:22949526 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO MK 2206 promotes the reaction [butein results in increased lipidation of MAP1LC3B protein] CTD PMID:35130734 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO MK 2206 promotes the reaction [Cadmium Chloride results in increased expression of MAP3K5 protein] CTD PMID:29444456 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO U 0126 promotes the reaction [MK 2206 results in decreased phosphorylation of MAPK1 protein]
[MK 2206 co-treated with mirdametinib] results in decreased phosphorylation of MAPK1 protein		 CTD PMID:27634878 PMID:30723155 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO MK 2206 results in decreased phosphorylation of MAPK3 protein
U 0126 promotes the reaction [MK 2206 results in decreased phosphorylation of MAPK3 protein]
[MK 2206 co-treated with mirdametinib] results in decreased phosphorylation of MAPK3 protein		 CTD PMID:27634878 PMID:30723155 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [mirdametinib co-treated with MK 2206] results in increased expression of MCL1 protein; [romidepsin co-treated with mirdametinib co-treated with MK 2206] results in increased expression of MCL1 protein; [romidepsin co-treated with MK 2206] results in increased expression of MCL1 protein CTD PMID:27634878 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO MTOR gene mutant form promotes the reaction [MK 2206 results in decreased expression of RPS6 protein modified form]
MK 2206 inhibits the reaction [Radon results in increased expression of MTOR protein modified form]		 CTD PMID:29384525 PMID:32949624 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP MK 2206 inhibits the reaction [PHLDA3 protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein]] CTD PMID:34351043 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of NOS3 protein CTD PMID:36049518 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [mirdametinib co-treated with MK 2206] results in increased cleavage of PARP1 protein; [romidepsin co-treated with MK 2206] results in increased cleavage of PARP1 protein; romidepsin promotes the reaction [[mirdametinib co-treated with MK 2206] results in increased cleavage of PARP1 protein] CTD PMID:27634878 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 multiple interactions EXP MK 2206 inhibits the reaction [PHLDA3 protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein]]; MK 2206 promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased phosphorylation of GSK3B protein]]; MK 2206 promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein]]; MK 2206 promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL6 protein]]; MK 2206 promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of TNF protein]] CTD PMID:34351043 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions ISO MK 2206 inhibits the reaction [PNPLA2 protein results in increased phosphorylation of AKT1 protein] CTD PMID:31476254 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO MK 2206 inhibits the reaction [Endrin results in increased expression of PPARG mRNA] CTD PMID:34801515 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; MK 2206 inhibits the reaction [Taurocholic Acid results in increased expression of PTGS2 protein] CTD PMID:26518876 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rarres2 retinoic acid receptor responder 2 multiple interactions ISO MK 2206 inhibits the reaction [RARRES2 protein results in decreased expression of EDNRB protein modified form]; MK 2206 inhibits the reaction [RARRES2 protein results in decreased expression of VEGFA protein]; MK 2206 inhibits the reaction [RARRES2 protein results in decreased secretion of IL10 protein]; MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of CD80 protein]; MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of CD86 protein]; MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of CEBPA protein]; MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of EDN1 protein]; MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of FLT1 protein modified form]; MK 2206 inhibits the reaction [RARRES2 protein results in increased expression of IRF8 protein]; MK 2206 inhibits the reaction [RARRES2 protein results in increased secretion of [IL12A protein binds to IL12B protein]]; MK 2206 inhibits the reaction [RARRES2 protein results in increased secretion of IL6 protein]; MK 2206 inhibits the reaction [RARRES2 protein results in increased secretion of TNF protein] CTD PMID:34398343 NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO MK 2206 inhibits the reaction [Particulate Matter results in increased phosphorylation of RELA protein] CTD PMID:32687961 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
multiple interactions
decreases expression		 ISO MK 2206 results in decreased phosphorylation of RPS6 protein
MTOR gene mutant form promotes the reaction [MK 2206 results in decreased expression of RPS6 protein modified form]		 CTD PMID:22885370 PMID:29384525 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO MK 2206 inhibits the reaction [Epirubicin results in increased phosphorylation of RPS6KB1 protein] CTD PMID:35872041 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions ISO MK 2206 inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:22949526 NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
decreases expression		 ISO [U 0126 co-treated with MK 2206] results in decreased expression of SNAI1 mRNA
MK 2206 results in decreased expression of SNAI1 mRNA
MK 2206 inhibits the reaction [Radon results in increased expression of SNAI1 protein]		 CTD PMID:30723155 PMID:32949624 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO [U 0126 co-treated with MK 2206] results in decreased expression of SNAI2 mRNA CTD PMID:30723155 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO MK 2206 binds to and results in increased activity of THRB protein CTD PMID:25752796 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO MK 2206 inhibits the reaction [Particulate Matter results in decreased expression of TJP1 protein] CTD PMID:32687961 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tmed3 transmembrane p24 trafficking protein 3 multiple interactions ISO MK 2206 inhibits the reaction [TMED3 protein results in increased expression of CTNNB1 protein]; MK 2206 inhibits the reaction [TMED3 protein results in increased phosphorylation of AKT1 protein]; MK 2206 inhibits the reaction [TMED3 protein results in increased phosphorylation of GSK3B protein] CTD PMID:34758370 NCBI chr 8:90,241,516...90,249,429
Ensembl chr 8:90,241,516...90,249,346 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases response to substance
decreases secretion		 ISO
EXP		 MK 2206 inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [3-nitrofluoranthene results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [AGT protein modified form results in increased secretion of TNF protein]; MK 2206 inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [RARRES2 protein results in increased secretion of TNF protein]
MK 2206 results in increased susceptibility to TNF protein
[MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of BAD protein; [MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CASP9 protein; [MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of FGF2 protein; [MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of KDR protein; [MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of NOS3 protein; [MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA protein; MK 2206 promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of TNF protein]]
MK 2206 results in decreased secretion of TNF protein		 CTD PMID:28633978 PMID:30354818 PMID:31445927 PMID:32687961 PMID:34351043 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [mirdametinib co-treated with MK 2206] results in increased expression of and results in increased phosphorylation of TRP53 protein CTD PMID:28691888 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO
EXP		 MK 2206 inhibits the reaction [RARRES2 protein results in decreased expression of VEGFA protein]
MK 2206 results in increased expression of VEGFA protein
[MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA protein		 CTD PMID:34398343 PMID:36049518 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions EXP
ISO		 MK 2206 inhibits the reaction [Diethylhexyl Phthalate results in increased expression of VIM protein]
MK 2206 inhibits the reaction [Radon results in increased expression of VIM protein]		 CTD PMID:29669060 PMID:32949624 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO MK 2206 promotes the reaction [Cadmium Chloride results in increased expression of XBP1 protein alternative form] CTD PMID:29444456 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions
increases expression		 ISO [U 0126 co-treated with MK 2206] results in increased expression of ZEB1 mRNA
MK 2206 results in increased expression of ZEB1 mRNA		 CTD PMID:30723155 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 multiple interactions
decreases expression		 ISO [U 0126 co-treated with MK 2206] results in decreased expression of ZEB2 mRNA
MK 2206 results in decreased expression of ZEB2 mRNA		 CTD PMID:30723155 NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      molecular entity 19829
        mancude ring 11179
          organic mancude parent 11179
            mancude organic heterocyclic parent 11179
              mancude organic heterobicyclic parent 8324
                naphthyridine 2296
                  1,6-naphthyridine 80
                    MK-2206 80
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteropolycyclic compound 18295
                                    organic heterobicyclic compound 17240
                                      mancude organic heterobicyclic parent 8324
                                        naphthyridine 2296
                                          1,6-naphthyridine 80
                                            MK-2206 80
paths to the root