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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:MK-2206
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Accession:CHEBI:67271 term browser browse the term
Definition:An organic heterotricyclic compound that is [1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one substituted at positions 8 and 9 respectively by 4-(1-aminocyclobutyl)phenyl and phenyl groups.
Synonyms:exact_synonym: 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one
 related_synonym: Formula=C25H21N5O;   InChI=1S/C25H21N5O/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31);   InChIKey=ULDXWLCXEDXJGE-UHFFFAOYSA-N;   SMILES=NC1(CCC1)c1ccc(cc1)-c1nc2ccn3c(n[nH]c3=O)c2cc1-c1ccccc1
 xref: LINCS:LSM-1057
 xref_mesh: MESH:C548887
 xref: Reaxys:18391321


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MK-2206 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO [gamma-mangostin co-treated with MK 2206] results in decreased expression of ACTA2 protein
MK 2206 results in decreased expression of ACTA2 protein
CTD PMID:30502394 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen multiple interactions ISO MK 2206 inhibits the reaction [AGT protein modified form results in increased secretion of IL6 protein]; MK 2206 inhibits the reaction [AGT protein modified form results in increased secretion of TNF protein] CTD PMID:30354818 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO
EXP
MK 2206 results in decreased phosphorylation of AKT1 protein
MK 2206 results in increased phosphorylation of AKT1 protein
[gamma-mangostin co-treated with MK 2206] results in decreased phosphorylation of AKT1 protein; [PD 0325901 co-treated with MK 2206] results in increased phosphorylation of AKT1 protein; MK 2206 inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of AKT1 protein]; MK 2206 inhibits the reaction [PNPLA2 protein results in increased phosphorylation of AKT1 protein]; MK 2206 results in decreased phosphorylation of and results in decreased activity of AKT1 protein; romidepsin inhibits the reaction [[PD 0325901 co-treated with MK 2206] results in increased phosphorylation of AKT1 protein]
LEPR affects the reaction [MK 2206 results in decreased phosphorylation of AKT1 protein]
MK 2206 inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of and results in increased expression of AKT1 protein]; MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]
CTD PMID:22885370, PMID:22949526, PMID:24685774, PMID:25597859, PMID:27634878, PMID:27897231, PMID:29669060, PMID:30502394, PMID:30723155, PMID:31445927, PMID:31476254 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt1s1 AKT1 substrate 1 decreases phosphorylation
multiple interactions
ISO MK 2206 results in decreased phosphorylation of AKT1S1 protein
[STO 609 co-treated with MK 2206] results in decreased phosphorylation of AKT1S1 protein
CTD PMID:28634229 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO MK 2206 inhibits the reaction [Cadmium Chloride results in increased expression of ATF4] CTD PMID:24057571 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO MK 2206 inhibits the reaction [Dexamethasone results in increased phosphorylation of BAD protein] CTD PMID:30878453 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [PD 0325901 co-treated with MK 2206] results in increased expression of BAK1 protein; [romidepsin co-treated with MK 2206] results in increased expression of BAK1 protein; [romidepsin co-treated with PD 0325901 co-treated with MK 2206] results in increased expression of BAK1 protein CTD PMID:27634878 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions ISO [PD 0325901 co-treated with MK 2206] results in increased expression of BCL2L11 protein; [romidepsin co-treated with MK 2206] results in increased expression of BCL2L11 protein; [romidepsin co-treated with PD 0325901 co-treated with MK 2206] results in increased expression of BCL2L11 protein CTD PMID:27634878 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [PD 0325901 co-treated with MK 2206] results in increased expression of BID mRNA; [PD 0325901 co-treated with MK 2206] results in increased expression of BID protein modified form CTD PMID:28691888 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO MK 2206 results in increased cleavage of CASP3 protein
MK 2206 inhibits the reaction [Dexamethasone results in increased cleavage of CASP3 protein]
[MK 2206 co-treated with platycodin D] results in increased activity of CASP3 protein; MK 2206 inhibits the reaction [Soot analog results in increased expression of CASP3 protein]
CTD PMID:22885370, PMID:27897231, PMID:30240709, PMID:30878453 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [MK 2206 co-treated with platycodin D] results in increased activity of CASP7 protein CTD PMID:27897231 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions ISO MK 2206 inhibits the reaction [Soot analog results in increased expression of CASP9 protein] CTD PMID:30240709 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO [MK 2206 co-treated with U 0126] results in increased expression of CDH1 mRNA
MK 2206 results in increased expression of CDH1 mRNA
CTD PMID:30723155 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Egfr epidermal growth factor receptor increases expression
multiple interactions
ISO MK 2206 results in increased expression of EGFR protein
platycodin D inhibits the reaction [MK 2206 results in increased expression of EGFR protein]
CTD PMID:27897231 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
ISO MK 2206 results in decreased phosphorylation of EIF4EBP1 protein
[platycodin D co-treated with MK 2206] results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:22885370, PMID:27897231 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
increases expression
ISO platycodin D inhibits the reaction [MK 2206 results in increased expression of ERBB2 protein] CTD PMID:27897231 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO MK 2206 promotes the reaction [Cadmium Chloride results in increased expression of ERN1 protein] CTD PMID:29444456 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO MK 2206 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO MK 2206 affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO
MK 2206 inhibits the reaction [Diethylhexyl Phthalate results in increased expression of FN1 protein]
[MK 2206 co-treated with U 0126] results in decreased expression of FN1 mRNA
CTD PMID:29669060, PMID:30723155 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP MK 2206 inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of GSK3B protein] CTD PMID:29669060 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]] CTD PMID:25597859 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO MK 2206 inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; MK 2206 inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein] CTD PMID:31018152 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO MK 2206 inhibits the reaction [AGT protein modified form results in increased secretion of IL6 protein] CTD PMID:30354818 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lep leptin multiple interactions ISO MK 2206 inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein] CTD PMID:27381457 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor multiple interactions ISO LEPR affects the reaction [MK 2206 results in decreased phosphorylation of AKT1 protein] CTD PMID:22949526 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO MK 2206 promotes the reaction [Cadmium Chloride results in increased expression of MAP3K5 protein] CTD PMID:29444456 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO U 0126 promotes the reaction [MK 2206 results in decreased phosphorylation of MAPK1 protein]
[MK 2206 co-treated with PD 0325901] results in decreased phosphorylation of MAPK1 protein
CTD PMID:27634878, PMID:30723155 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO MK 2206 results in decreased phosphorylation of MAPK3 protein
[MK 2206 co-treated with PD 0325901] results in decreased phosphorylation of MAPK3 protein
U 0126 promotes the reaction [MK 2206 results in decreased phosphorylation of MAPK3 protein]
CTD PMID:27634878, PMID:30723155 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [PD 0325901 co-treated with MK 2206] results in increased expression of MCL1 protein; [romidepsin co-treated with MK 2206] results in increased expression of MCL1 protein; [romidepsin co-treated with PD 0325901 co-treated with MK 2206] results in increased expression of MCL1 protein CTD PMID:27634878 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO MTOR gene mutant form promotes the reaction [MK 2206 results in decreased expression of RPS6 protein modified form] CTD PMID:29384525 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [PD 0325901 co-treated with MK 2206] results in increased cleavage of PARP1 protein; [romidepsin co-treated with MK 2206] results in increased cleavage of PARP1 protein; romidepsin promotes the reaction [[PD 0325901 co-treated with MK 2206] results in increased cleavage of PARP1 protein] CTD PMID:27634878 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions ISO MK 2206 inhibits the reaction [PNPLA2 protein results in increased phosphorylation of AKT1 protein] CTD PMID:31476254 NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; MK 2206 inhibits the reaction [Taurocholic Acid results in increased expression of PTGS2 protein] CTD PMID:26518876 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
decreases expression
multiple interactions
ISO MK 2206 results in decreased phosphorylation of RPS6 protein
MK 2206 results in decreased expression of RPS6 protein modified form
MTOR gene mutant form promotes the reaction [MK 2206 results in decreased expression of RPS6 protein modified form]
CTD PMID:22885370, PMID:29384525 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions ISO MK 2206 inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:22949526 NCBI chr19:11,106,033...11,144,674
Ensembl chr19:11,106,033...11,144,641
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
decreases expression
ISO [U 0126 co-treated with MK 2206] results in decreased expression of SNAI1 mRNA
MK 2206 results in decreased expression of SNAI1 mRNA
CTD PMID:30723155 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO [U 0126 co-treated with MK 2206] results in decreased expression of SNAI2 mRNA CTD PMID:30723155 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO MK 2206 binds to and results in increased activity of THRB protein CTD PMID:25752796 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases response to substance
ISO MK 2206 inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [3-nitrofluoranthene results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [AGT protein modified form results in increased secretion of TNF protein]
MK 2206 results in increased susceptibility to TNF protein
CTD PMID:28633978, PMID:30354818, PMID:31445927 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [PD 0325901 co-treated with MK 2206] results in increased expression of and results in increased phosphorylation of TRP53 protein CTD PMID:28691888 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vim vimentin multiple interactions EXP MK 2206 inhibits the reaction [Diethylhexyl Phthalate results in increased expression of VIM protein] CTD PMID:29669060 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO MK 2206 promotes the reaction [Cadmium Chloride results in increased expression of XBP1 protein alternative form] CTD PMID:29444456 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions
increases expression
ISO [U 0126 co-treated with MK 2206] results in increased expression of ZEB1 mRNA
MK 2206 results in increased expression of ZEB1 mRNA
CTD PMID:30723155 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 multiple interactions
decreases expression
ISO [U 0126 co-treated with MK 2206] results in decreased expression of ZEB2 mRNA
MK 2206 results in decreased expression of ZEB2 mRNA
CTD PMID:30723155 NCBI chr 3:29,857,289...29,985,932
Ensembl chr 3:29,862,473...29,996,865
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        mancude ring 8105
          organic mancude parent 8105
            mancude organic heterocyclic parent 8105
              mancude organic heterobicyclic parent 5189
                naphthyridine 765
                  1,6-naphthyridine 45
                    MK-2206 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterobicyclic compound 16742
                                      mancude organic heterobicyclic parent 5189
                                        naphthyridine 765
                                          1,6-naphthyridine 45
                                            MK-2206 45
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.