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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:HIV-1 integrase inhibitor
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Accession:CHEBI:67268 term browser browse the term
Definition:An inhibitor of HIV-1 integrase, an enzyme required for the integration of the genetic material of the retrovirus into the DNA of the infected cells.
Synonyms:xref: Wikipedia:Discovery_and_development_of_integrase_inhibitors


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bictegravir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO bictegravir results in decreased expression of ALDH1A2 mRNA CTD PMID:34515794 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO bictegravir results in increased expression of CYP26A1 mRNA CTD PMID:34515794 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO bictegravir results in increased expression of FGF8 mRNA CTD PMID:34515794 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Mixl1 Mix paired-like homeobox 1 increases expression ISO bictegravir results in increased expression of MIXL1 mRNA CTD PMID:34515794 NCBI chr13:92,422,031...92,426,065
Ensembl chr13:92,422,031...92,426,065 		JBrowse link
chicoric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation EXP chicoric acid results in increased phosphorylation of ACACA protein CTD PMID:24244361 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:24244361 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cs citrate synthase increases activity EXP chicoric acid results in increased activity of CS protein CTD PMID:24244361 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of MTOR protein] CTD PMID:24244361 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of MTOR protein] CTD PMID:24244361 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP chicoric acid results in increased expression of PPARGC1A mRNA CTD PMID:24244361 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP chicoric acid results in increased expression of SOD2 protein CTD PMID:24244361 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
dolutegravir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO dolutegravir results in decreased expression of ALDH1A2 mRNA CTD PMID:34515794 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Cdx1 caudal type homeo box 1 decreases expression ISO dolutegravir results in decreased expression of CDX1 mRNA CTD PMID:34515794 NCBI chr18:54,472,587...54,490,913
Ensembl chr18:54,473,444...54,490,814 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression
increases expression		 ISO dolutegravir results in decreased expression of CYP26A1 mRNA
dolutegravir results in increased expression of CYP26A1 mRNA		 CTD PMID:34515794 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO dolutegravir results in increased expression of FGF8 mRNA CTD PMID:34515794 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Hoxb1 homeo box B1 increases expression ISO dolutegravir results in increased expression of HOXB1 mRNA CTD PMID:34515794 NCBI chr10:81,331,507...81,332,928
Ensembl chr10:81,331,507...81,332,836 		JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO dolutegravir results in decreased expression of HOXB9 mRNA CTD PMID:34515794 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818 		JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO dolutegravir results in decreased expression of MEOX1 mRNA CTD PMID:34515794 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660 		JBrowse link
G Mesp2 mesoderm posterior bHLH transcription factor 2 increases expression ISO dolutegravir results in increased expression of MESP2 mRNA CTD PMID:34515794 NCBI chr 1:133,756,601...133,759,207
Ensembl chr 1:133,756,601...133,759,198 		JBrowse link
G Mixl1 Mix paired-like homeobox 1 increases expression ISO dolutegravir results in increased expression of MIXL1 mRNA CTD PMID:34515794 NCBI chr13:92,422,031...92,426,065
Ensembl chr13:92,422,031...92,426,065 		JBrowse link
G Tbx6 T-box transcription factor 6 increases expression ISO dolutegravir results in increased expression of TBX6 mRNA CTD PMID:34515794 NCBI chr 1:181,387,851...181,392,762
Ensembl chr 1:181,388,684...181,392,593 		JBrowse link
elvitegravir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO elvitegravir results in decreased expression of ALDH1A2 mRNA CTD PMID:34515794 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO elvitegravir results in increased expression of FGF8 mRNA CTD PMID:34515794 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        antimicrobial agent 18125
          antiviral agent 11069
            anti-HIV agent 2719
              anti-HIV-1 agent 890
                HIV-1 integrase inhibitor 17
                  7-oxohernangerine 0
                  australifungin 0
                  bictegravir 4
                  bictegravir sodium 0
                  cabotegravir 0
                  cabotegravir sodium 0
                  chicoric acid 7
                  complestatin A 0
                  complestatin B 0
                  cytosporic acid 0
                  dolutegravir 10
                  dolutegravir sodium 0
                  elvitegravir + 2
                  equisetin 0
                  hernandonine 0
                  integracin A 0
                  integracin B 0
                  integracin C 0
                  integrastatin A 0
                  integrastatin B 0
                  integric acid 0
                  isocomplestatin 0
                  lamellarin alpha 20-hydrogen sulfate 0
                  lamellarin alpha 20-sulfate 0
                  laurolistine + 0
                  lindechunine A 0
                  raltegravir 0
paths to the root