Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor
go back to main search page
Accession:CHEBI:67267 term browser browse the term
Definition:An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of protein geranylgeranyltransferase type I (EC 2.5.1.59).
Synonyms:related_synonym: EC 2.5.1.59 inhibitor;   EC 2.5.1.59 inhibitors;   GGTase I inhibitor;   GGTase I inhibitors;   geranylgeranyl-diphosphate:protein-cysteine geranyltransferase inhibitor;   geranylgeranyl-diphosphate:protein-cysteine geranyltransferase inhibitors;   geranylgeranyltransferase type I inhibitor;   geranylgeranyltransferase type I inhibitors;   protein geranylgeranyltransferase type I (EC 2.5.1.59) inhibitors;   protein geranylgeranyltransferase type I inhibitor;   protein geranylgeranyltransferase type I inhibitors
 xref: Wikipedia:Protein_geranylgeranyltransferase_type_I



show annotations for term's descendants           Sort by:
 
GGTI-2133 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP GGTI-2133 inhibits the reaction [Smoke analog results in increased phosphorylation of AKT1 protein] CTD PMID:19299917 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP GGTI-2133 inhibits the reaction [Smoke analog results in increased phosphorylation of MAPK1 protein] CTD PMID:19299917 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP GGTI-2133 inhibits the reaction [Smoke analog results in increased phosphorylation of MAPK3 protein] CTD PMID:19299917 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP GGTI-2133 inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]; GGTI-2133 inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein] CTD PMID:19299917 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases geranoylation ISO GGTI-2133 results in decreased geranoylation of RAP1A protein CTD PMID:25578243 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19727
    role 19700
      biological role 19698
        biochemical role 19412
          enzyme inhibitor 18528
            EC 2.* (transferase) inhibitor 14626
              EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor 2482
                EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor 2482
                  EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor 5
                    GGTI-2133 5
                    GGTI-2133 free base 0
                    L-778,123 (free base) + 0
                    L-778,123 hydrochloride 0
                    citrafungin A 0
                    citrafungin B 0
                    massadine 0
paths to the root