Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-diketone
go back to main search page
Accession:CHEBI:67265 term browser browse the term
Definition:A diketone in which the two keto groups are separated by a single carbon atom.
Synonyms:related_synonym: 1,3-diketone;   1,3-diketones;   beta-diketones



show annotations for term's descendants           Sort by:
4,6-dioxoheptanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA]
succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]
CTD PMID:21659532 PMID:22859313 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO succinylacetone results in increased expression of HMOX1 mRNA CTD PMID:22859313 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 gene mutant form affects the reaction [succinylacetone results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA] CTD PMID:22859313 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO succinylacetone results in increased expression of PPARGC1A mRNA CTD PMID:22859313 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
bisdemethoxycurcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO bisdemethoxycurcumin results in decreased activity of ABCC1 protein; curcumin III results in decreased activity of ABCC1 protein CTD PMID:15885658 PMID:16021489 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO bisdemethoxycurcumin results in decreased activity of ABCC2 protein CTD PMID:15885658 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases expression
multiple interactions
ISO bisdemethoxycurcumin results in increased phosphorylation of AKT1 protein
bisdemethoxycurcumin results in decreased expression of AKT1 protein modified form
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]
AKT1 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]
CTD PMID:17535857 PMID:35735092 PMID:35752269 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR2 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR3 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR4 mRNA; [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of VDR mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR2 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR4 mRNA; bisdemethoxycurcumin inhibits the reaction [APP protein binds to APP protein] CTD PMID:19715544 PMID:22029407 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO bisdemethoxycurcumin results in increased expression of CD36 mRNA
bisdemethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]
CTD PMID:23386263 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO bisdemethoxycurcumin results in decreased expression of EGFR protein modified form CTD PMID:35735092 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases response to substance
decreases expression
ISO ERBB2 protein results in increased susceptibility to bisdemethoxycurcumin
bisdemethoxycurcumin results in decreased expression of ERBB2 protein
CTD PMID:34291863 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO bisdemethoxycurcumin results in increased expression of GCLM mRNA; bisdemethoxycurcumin results in increased expression of GCLM protein CTD PMID:17535857 PMID:19188863 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO bisdemethoxycurcumin results in decreased expression of GRB2 protein CTD PMID:35735092 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO bisdemethoxycurcumin results in increased expression of HMOX1 mRNA; bisdemethoxycurcumin results in increased expression of HMOX1 protein
[demethoxycurcumin co-treated with bisdemethoxycurcumin] results in increased expression of HMOX1 mRNA; AKT1 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; KEAP1 protein inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; PRKCD protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]
CTD PMID:17535857 PMID:19188863 PMID:23386263 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein] CTD PMID:35752269 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO KEAP1 protein inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA] CTD PMID:17535857 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases expression
multiple interactions
ISO bisdemethoxycurcumin results in increased phosphorylation of MAPK1 protein
bisdemethoxycurcumin results in decreased expression of MAPK1 protein modified form
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:17535857 PMID:35735092 PMID:35752269 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
decreases expression
multiple interactions
ISO bisdemethoxycurcumin results in increased phosphorylation of MAPK3 protein
bisdemethoxycurcumin results in decreased expression of MAPK3 protein modified form
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:17535857 PMID:35735092 PMID:35752269 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mgat3 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase multiple interactions
increases expression
ISO [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of MGAT3 mRNA
bisdemethoxycurcumin results in increased expression of MGAT3 mRNA
CTD PMID:19090986 PMID:22029407 NCBI chr 7:111,708,353...111,761,825
Ensembl chr 7:111,675,730...111,762,026
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression ISO bisdemethoxycurcumin results in decreased expression of MMP14 protein CTD PMID:18495463 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO bisdemethoxycurcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form
bisdemethoxycurcumin results in decreased expression of MMP2 protein
CTD PMID:18495463 PMID:35735092 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO bisdemethoxycurcumin results in decreased secretion of and results in decreased activity of MMP9 protein
bisdemethoxycurcumin results in decreased expression of MMP9 protein
CTD PMID:18495463 PMID:35735092 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO bisdemethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:23386263 NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions
ISO bisdemethoxycurcumin affects the localization of NFE2L2 protein
[demethoxycurcumin co-treated with bisdemethoxycurcumin] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]
CTD PMID:17535857 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18449507 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:18449507 PMID:18481332 PMID:18838107 PMID:19188055 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO bisdemethoxycurcumin results in increased expression of NQO1 mRNA; bisdemethoxycurcumin results in increased expression of NQO1 protein CTD PMID:17535857 PMID:19188863 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases expression ISO bisdemethoxycurcumin results in decreased expression of PDPK1 protein modified form CTD PMID:35735092 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Plau plasminogen activator, urokinase decreases secretion ISO bisdemethoxycurcumin results in decreased secretion of PLAU protein CTD PMID:18495463 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO bisdemethoxycurcumin binds to PPARG protein CTD PMID:15713005 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO PRKCD protein affects the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA] CTD PMID:17535857 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:18449507 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO bisdemethoxycurcumin results in decreased expression of RAF1 protein modified form CTD PMID:35735092 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO bisdemethoxycurcumin results in decreased expression of SOS1 protein CTD PMID:35735092 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression ISO bisdemethoxycurcumin results in decreased expression of TIMP1 protein CTD PMID:35735092 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression ISO bisdemethoxycurcumin results in decreased expression of TIMP2 protein CTD PMID:18495463 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR2 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR2 mRNA CTD PMID:22029407 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR3 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR3 mRNA CTD PMID:22029407 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of TLR4 mRNA; [bisdemethoxycurcumin co-treated with APP protein] results in increased expression of TLR4 mRNA CTD PMID:22029407 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; bisdemethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:18838107 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of VDR mRNA CTD PMID:22029407 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:35752269 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wt1 WT1 transcription factor decreases expression ISO bisdemethoxycurcumin results in decreased expression of WT1 mRNA; bisdemethoxycurcumin results in decreased expression of WT1 protein CTD PMID:18034345 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
JBrowse link
curcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A4galt alpha 1,4-galactosyltransferase multiple interactions ISO Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA] CTD PMID:16819191 NCBI chr 7:114,368,525...114,392,872
Ensembl chr 7:114,368,276...114,396,071
JBrowse link
G Aars1 alanyl-tRNA synthetase 1 decreases expression ISO Curcumin results in decreased expression of AARS1 mRNA CTD PMID:17198877 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]] CTD PMID:33952798 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
decreases response to substance
decreases expression
multiple interactions
ISO ABCB1 affects the susceptibility to Curcumin
ABCB1 protein results in decreased susceptibility to Curcumin
Curcumin analog results in decreased expression of ABCB1 protein; Curcumin results in decreased expression of ABCB1 mRNA; Curcumin results in decreased expression of ABCB1B mRNA
[Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ABCB1 mRNA]
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [sulfinosine co-treated with Curcumin] results in decreased expression of ABCB1 mRNA; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin results in decreased expression of and results in decreased activity of ABCB1 protein
CTD PMID:15476675 PMID:17121181 PMID:18200517 PMID:18385293 PMID:18414057 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein]; [Curcumin results in decreased expression of ABCB1B protein] which results in increased susceptibility to Doxorubicin; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]
Curcumin results in decreased expression of ABCB1B mRNA; Curcumin results in decreased expression of ABCB1B protein
CTD PMID:18006147 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
decreases expression
ISO Curcumin results in decreased activity of ABCC1 protein
Curcumin analog results in decreased expression of ABCC1 mRNA
CTD PMID:15885658 PMID:16021489 PMID:26409325 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
multiple interactions
ISO Curcumin results in decreased activity of ABCC2 protein
[Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 protein
CTD PMID:15885658 PMID:35243748 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 protein CTD PMID:35243748 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO [Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; Curcumin analog binds to and results in decreased activity of ABCC5 protein; Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; Curcumin binds to and results in decreased activity of ABCC5 protein; Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Curcumin results in increased expression of ABCG1 mRNA CTD PMID:16713233 PMID:21594647 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases expression
increases expression
ISO AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin results in decreased expression of ABCG2 mRNA
CTD PMID:17077187 PMID:33539684 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation
decreases expression
affects expression
multiple interactions
ISO
EXP
Curcumin results in increased phosphorylation of ACACA protein
Curcumin results in decreased expression of ACACA mRNA
Curcumin affects the expression of ACACA mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA protein]; Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein]
CTD PMID:18790744 PMID:19297423 PMID:27208389 PMID:37701206 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acacb acetyl-CoA carboxylase beta multiple interactions ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB protein] CTD PMID:37701206 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein] CTD PMID:10666014 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions EXP Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein] CTD PMID:26648693 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of ACHE protein]
Curcumin results in decreased activity of ACHE protein
Curcumin inhibits the reaction [Acrylamide results in increased activity of ACHE protein]; Curcumin inhibits the reaction [aluminum acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE protein]; Curcumin inhibits the reaction [lead acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
CTD PMID:18809455 PMID:20369229 PMID:21839772 PMID:22783142 PMID:25199698 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ackr3 atypical chemokine receptor 3 increases expression ISO Curcumin results in increased expression of ACKR3 mRNA CTD PMID:21594647 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
JBrowse link
G Acly ATP citrate lyase affects expression
decreases expression
ISO
EXP
Curcumin affects the expression of ACLY mRNA
Curcumin results in decreased expression of ACLY mRNA
CTD PMID:27208389 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Aco2 aconitase 2 multiple interactions EXP Curcumin inhibits the reaction [Potassium Dichromate results in decreased activity of ACO2 protein] CTD PMID:25130536 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP
ISO
Curcumin results in decreased expression of ACTA2 mRNA; Curcumin results in decreased expression of ACTA2 protein
Curcumin inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Arsenic Trioxide promotes the reaction [Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]]
CTD PMID:17355460 PMID:17531121 PMID:18006644 PMID:22683883 PMID:27363783 More... NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA] CTD PMID:17666914 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 increases expression ISO Curcumin results in increased expression of ADAMTS4 mRNA CTD PMID:18321735 NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065
JBrowse link
G Adcy9 adenylate cyclase 9 decreases expression ISO Curcumin results in decreased expression of ADCY9 mRNA CTD PMID:15713895 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 decreases expression ISO Curcumin results in decreased expression of ADGRE1 mRNA CTD PMID:18403477 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions
affects expression
ISO
EXP
Curcumin results in increased expression of ADIPOQ mRNA; Curcumin results in increased expression of ADIPOQ protein
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]
Curcumin affects the expression of ADIPOQ mRNA
Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]
CTD PMID:18403477 PMID:26713546 PMID:27208389 PMID:28595985 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adora2a adenosine A2a receptor multiple interactions ISO [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Curcumin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA] CTD PMID:31820278 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein] CTD PMID:29480285 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member decreases expression ISO Curcumin results in decreased expression of AGR2 mRNA CTD PMID:17198877 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of AGT protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of AGT protein]
CTD PMID:26612707 PMID:26648693 PMID:31820278 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein] CTD PMID:26648693 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding
increases degradation
ISO AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin binds to AHR protein
Curcumin results in increased degradation of AHR protein
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of AHR protein]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]; Curcumin promotes the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
CTD PMID:17077187 PMID:17880909 PMID:18321868 PMID:19018768 PMID:25632966 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ak1 adenylate kinase 1 multiple interactions ISO [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein CTD PMID:25866362 NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
JBrowse link
G Akap6 A-kinase anchoring protein 6 increases expression
multiple interactions
ISO Curcumin results in increased expression of AKAP6 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA]
CTD PMID:18200517 PMID:18421014 NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases expression
multiple interactions
increases activity
ISO
EXP
Curcumin results in increased expression of AKR1B1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]
Curcumin results in increased expression of AKR1B1 mRNA; Curcumin results in increased expression of AKR1B1 protein
Curcumin results in increased activity of AKR1B1 protein
CTD PMID:17640564 PMID:18200517 PMID:18299980 PMID:18588981 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects phosphorylation
decreases expression
decreases phosphorylation
increases expression
increases phosphorylation
decreases activity
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
Curcumin affects the phosphorylation of AKT1 protein
Curcumin analog results in decreased expression of AKT1 mRNA; Curcumin results in decreased expression of AKT1 protein
Curcumin results in increased expression of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
Curcumin results in decreased activity of AKT1 protein
CTD PMID:16023083 PMID:16219905 PMID:17289836 PMID:17291458 PMID:17332930 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions
decreases phosphorylation
decreases expression
ISO 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT2 protein
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]
Curcumin analog results in decreased expression of AKT2 mRNA
CTD PMID:23452621 PMID:26409325 PMID:36640941 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions
decreases expression
decreases phosphorylation
ISO ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]
Curcumin results in decreased expression of AKT3 protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT3 protein; MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein]
CTD PMID:36640941 PMID:37471645 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions EXP
ISO
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein]
Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein]
CTD PMID:22704994 PMID:23292317 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression EXP Curcumin results in increased expression of ALAS1 mRNA CTD PMID:18299980 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alb albumin multiple interactions EXP [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of ALB protein]; [Curcumin analog co-treated with Hydrogels] results in increased expression of ALB protein; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ALB protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]] CTD PMID:18204486 PMID:18809455 PMID:20804811 PMID:24704557 PMID:27288928 More... NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Alcam activated leukocyte cell adhesion molecule decreases expression ISO Curcumin results in decreased expression of ALCAM mRNA CTD PMID:33539684 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
decreases expression
ISO [Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 mRNA]; [Calcitriol co-treated with Paclitaxel] promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; [Curcumin co-treated with Paclitaxel] promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; Paclitaxel promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]
Curcumin results in decreased expression of ALDH1A1 mRNA; Curcumin results in decreased expression of ALDH1A1 protein
CTD PMID:31628941 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A decreases expression ISO Curcumin results in decreased expression of ALDOA mRNA CTD PMID:16880289 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO Curcumin results in decreased expression of ALDOC mRNA CTD PMID:17198877 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
decreases activity
EXP [Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein
Curcumin results in decreased activity of ALOX5 protein
CTD PMID:16956363 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Ampd1 adenosine monophosphate deaminase 1 multiple interactions ISO Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of AMPD1 protein] CTD PMID:36924976 NCBI chr 2:190,598,707...190,619,938
Ensembl chr 2:190,598,700...190,619,938
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression EXP Curcumin results in increased expression of AMPD3 mRNA CTD PMID:18299980 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression ISO Curcumin results in decreased expression of ANKRD37 mRNA CTD PMID:17198877 NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963
JBrowse link
G Ankrd50 ankyrin repeat domain containing 50 decreases expression ISO Curcumin results in decreased expression of ANKRD50 mRNA CTD PMID:17999991 NCBI chr 2:121,466,275...121,500,758
Ensembl chr 2:121,468,573...121,500,752
JBrowse link
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 decreases expression ISO Curcumin results in decreased expression of ANKZF1 mRNA CTD PMID:17198877 NCBI chr 9:76,688,194...76,695,162
Ensembl chr 9:76,688,194...76,696,469
JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions EXP
ISO
Curcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein]
Curcumin inhibits the reaction [deoxynivalenol results in increased activity of AOC1 protein]
CTD PMID:20885979 PMID:35817260 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of APAF1 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]
CTD PMID:17277231 PMID:20869986 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apc APC regulator of WNT signaling pathway decreases expression ISO Curcumin results in decreased expression of APC mRNA CTD PMID:15713895 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Apoe apolipoprotein E affects expression ISO Curcumin affects the expression of APOE mRNA CTD PMID:27208389 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases expression
ISO
EXP
Curcumin affects the reaction [APP protein binds to APP protein]; Curcumin inhibits the reaction [Copper results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP protein]
Curcumin results in increased expression of APP mRNA
[Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]
CTD PMID:18537544 PMID:18583042 PMID:27793699 PMID:30946834 PMID:31521693 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) decreases expression
multiple interactions
ISO Curcumin results in decreased expression of AQP3 protein
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]
CTD PMID:18214481 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
decreases activity
decreases expression
ISO [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR mRNA; [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR protein; [Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin promotes the reaction [Quercetin results in increased expression of AR mRNA]; Curcumin promotes the reaction [Quercetin results in increased expression of AR protein]; Quercetin promotes the reaction [Curcumin results in increased expression of AR mRNA]; Quercetin promotes the reaction [Curcumin results in increased expression of AR protein]
Curcumin results in increased expression of AR mRNA; Curcumin results in increased expression of AR protein
Curcumin results in decreased activity of AR protein
Curcumin results in decreased expression of AR mRNA; Curcumin results in decreased expression of AR protein
CTD PMID:12497104 PMID:18676361 PMID:18719366 PMID:22258452 PMID:27132804 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arhgap24 Rho GTPase activating protein 24 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA] CTD PMID:18200517 NCBI chr14:6,800,624...7,183,877
Ensembl chr14:6,800,631...7,183,823
JBrowse link
G Arhgap30 Rho GTPase activating protein 30 decreases expression ISO Curcumin results in decreased expression of ARHGAP30 mRNA CTD PMID:18421014 NCBI chr13:83,822,290...83,843,634
Ensembl chr13:83,822,283...83,854,885
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARHGDIB mRNA] CTD PMID:18200517 NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions
increases degradation
decreases expression
ISO Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; Curcumin results in increased ubiquitination of and results in increased degradation of ARNT protein
Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
Curcumin results in decreased expression of ARNT protein
CTD PMID:16880289 PMID:17880909 PMID:18682687 PMID:19018768 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA] CTD PMID:23452621 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G Atf2 activating transcription factor 2 decreases expression ISO Curcumin analog results in decreased expression of ATF2 mRNA CTD PMID:26409325 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Curcumin results in increased expression of ATF3 mRNA; Curcumin results in increased expression of ATF3 protein CTD PMID:15713895 PMID:18555241 PMID:18719366 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
decreases expression
ISO ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]
ATF4 inhibits the reaction [Curcumin results in decreased expression of ATF4 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]
CTD PMID:36640941 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Curcumin results in increased expression of ATF6 protein
Curcumin results in increased expression of ATF6 mRNA
CTD PMID:21793155 PMID:29723631 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase decreases expression
multiple interactions
ISO Curcumin results in decreased expression of ATG4B protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of ATG4B protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG4B protein]
CTD PMID:36640941 NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103
JBrowse link
G Atg5 autophagy related 5 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of ATG5 protein
Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG5 protein]
CTD PMID:36640941 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases phosphorylation
ISO [Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein
Curcumin results in increased phosphorylation of ATM protein
CTD PMID:19401701 PMID:21134073 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Aurka aurora kinase A decreases expression ISO Curcumin analog results in decreased expression of AURKA mRNA CTD PMID:26409325 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Curcumin analog results in decreased expression of AURKB mRNA CTD PMID:26409325 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Axin1 axin 1 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA]
Curcumin results in increased expression of AXIN1 mRNA
CTD PMID:25963729 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615
JBrowse link
G B3galt6 Beta-1,3-galactosyltransferase 6 increases expression ISO Curcumin results in increased expression of B3GALT6 mRNA CTD PMID:17198877 NCBI chr 5:166,584,202...166,586,338
Ensembl chr 5:166,584,202...166,586,338
JBrowse link
G Bace1 beta-secretase 1 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA]
Curcumin results in increased expression of BACE1 mRNA
CTD PMID:18583042 PMID:31521693 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of BAD mRNA; Curcumin results in increased expression of BAD protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of BAD protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAD protein]
CTD PMID:15569404 PMID:19235267 PMID:27430728 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
decreases expression
increases expression
increases response to substance
ISO TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]
Curcumin results in decreased expression of BAK1 mRNA
Curcumin results in increased expression of BAK1 mRNA; Curcumin results in increased expression of BAK1 protein
BAK1 protein results in increased susceptibility to Curcumin
CTD PMID:17277231 PMID:17332930 PMID:18226269 PMID:33582110 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
decreases expression
increases expression
affects localization
increases response to substance
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Sirolimus] results in increased expression of BAX; [Doxorubicin co-treated with Curcumin] results in increased expression of BAX mRNA; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; piperine inhibits the reaction [Curcumin results in decreased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein]
Curcumin affects the expression of BAX protein
Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein
Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of BAX protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]
BAX protein results in increased susceptibility to Curcumin
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin affects the localization of and results in increased expression of and results in increased activity of BAX protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX protein]
CTD PMID:15569404 PMID:17096185 PMID:17277231 PMID:17332930 PMID:17531121 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions
decreases expression
ISO
EXP
Curcumin results in increased expression of BBC3 mRNA
Curcumin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]
Curcumin results in decreased expression of BBC3 mRNA
CTD PMID:17332930 PMID:22714040 PMID:34047412 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl10 BCL10, immune signaling adaptor multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL10 mRNA] CTD PMID:23452621 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] affects the expression of BCL2 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased expression of BCL2 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2 protein; [Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; [Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein; [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Curcumin] results in decreased expression of BCL2 mRNA; [piperine co-treated with Curcumin] results in decreased expression of BCL2 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of BCL2 protein; Curcumin inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin promotes the reaction [Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]
Curcumin results in increased expression of BCL2 mRNA; Curcumin results in increased expression of BCL2 protein
Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
Curcumin analog results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in increased expression of BCL2 protein]; Curcumin affects the reaction [Ketamine results in decreased expression of BCL2 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]
CTD PMID:12497104 PMID:14724571 PMID:15569404 PMID:16023083 PMID:16219905 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]
Curcumin results in decreased expression of BCL2A1 mRNA
CTD PMID:16219905 PMID:17596214 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
increases expression
ISO
EXP
[Curcumin co-treated with Doxorubicin] affects the expression of BCL2L1 mRNA; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]
Curcumin analog results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2L1 protein
Curcumin results in increased expression of BCL2L1 mRNA
CTD PMID:12497104 PMID:15569404 PMID:15911101 PMID:16023083 PMID:16173963 More... NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression
multiple interactions
ISO Curcumin results in increased expression of BCL2L11 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BCL2L11 protein
CTD PMID:17332930 PMID:27430728 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression
multiple interactions
ISO Curcumin results in increased expression of BCL2L2 mRNA
[arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein
CTD PMID:16101141 PMID:27430728 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Bcl3 BCL3, transcription coactivator multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL3 mRNA]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL3 mRNA]
CTD PMID:18200517 PMID:23452621 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Bcor BCL6 co-repressor increases expression ISO Curcumin results in increased expression of BCOR mRNA CTD PMID:17198877 NCBI chr  X:10,609,756...10,729,613
Ensembl chr  X:10,687,732...10,729,613
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
affects expression
EXP
ISO
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BDNF protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein]
Curcumin results in increased expression of BDNF protein
Curcumin affects the expression of BDNF protein
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of BDNF mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BDNF protein]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]
CTD PMID:17022948 PMID:17617388 PMID:17827730 PMID:19033880 PMID:22911773 More... NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 increases expression
decreases expression
ISO Curcumin results in increased expression of BECN1 protein
Curcumin results in decreased expression of BECN1 protein
CTD PMID:34634291 PMID:36640941 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bgn biglycan multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA] CTD PMID:18200517 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in decreased expression of BID protein; [arsenic trioxide co-treated with Curcumin] results in increased expression of BID protein; Curcumin promotes the reaction [arsenic trioxide results in increased activity of BID protein] CTD PMID:20605902 PMID:27430728 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions
ISO Curcumin analog results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]
CTD PMID:16023083 PMID:16219905 PMID:16243823 PMID:17596214 PMID:17640567 More... NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
increases expression
decreases expression
ISO [arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC3 protein; [Curcumin co-treated with Doxorubicin] affects the expression of BIRC3 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC3 protein
Curcumin results in increased expression of BIRC3 mRNA
Curcumin results in decreased expression of BIRC3 mRNA; Curcumin results in decreased expression of BIRC3 protein
CTD PMID:15911101 PMID:16101141 PMID:16219905 PMID:16243823 PMID:17440100 More... NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] results in decreased expression of BIRC5 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BIRC5 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of BIRC5 protein]
Curcumin inhibits the reaction [Doxorubicin results in decreased expression of BIRC5 protein]
Curcumin analog results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC5 protein
CTD PMID:16023083 PMID:17440100 PMID:17596214 PMID:17671737 PMID:18593936 More... NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 increases expression
multiple interactions
ISO Curcumin results in increased expression of BIRC7 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BIRC7 protein
CTD PMID:15911101 PMID:27430728 NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606
JBrowse link
G Bmp2 bone morphogenetic protein 2 decreases expression ISO Curcumin results in decreased expression of BMP2 mRNA CTD PMID:27237783 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein] CTD PMID:27996348 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Bsg basigin (Ok blood group) decreases response to substance ISO BSG protein results in decreased susceptibility to Curcumin CTD PMID:18379992 NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
JBrowse link
G C1qa complement C1q A chain decreases expression ISO Curcumin results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C1qb complement C1q B chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA] CTD PMID:18200517 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
JBrowse link
G C3 complement C3 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA] CTD PMID:18200517 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C4b complement C4B multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA] CTD PMID:18200517 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO
EXP
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA
Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CAMK2A protein]
CTD PMID:22911773 PMID:29723552 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Capg capping actin protein, gelsolin like multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CAPG mRNA] CTD PMID:18200517 NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856
JBrowse link
G Car9 carbonic anhydrase 9 decreases expression EXP Curcumin results in decreased expression of CAR9 mRNA CTD PMID:18299980 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Casp1 caspase 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of CASP1 mRNA
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP1 mRNA]
CTD PMID:16101141 PMID:23452621 PMID:34998855 PMID:35063475 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of CASP12 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]
CTD PMID:21793155 PMID:25541178 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp2 caspase 2 increases expression ISO Curcumin results in increased expression of CASP2 mRNA CTD PMID:16101141 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases cleavage
increases activity
decreases activity
increases expression
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP3 protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]
Curcumin results in decreased expression of CASP3 protein modified form
Curcumin results in increased cleavage of CASP3 protein
Curcumin results in decreased activity of CASP3 protein
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin results in decreased cleavage of and results in decreased activity of CASP3 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CASP3 protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]
Curcumin results in increased expression of CASP3 mRNA; Curcumin results in increased expression of CASP3 protein; Curcumin results in increased expression of CASP3 protein modified form
Curcumin analog results in increased activity of CASP3 protein; Curcumin results in increased activity of CASP3; Curcumin results in increased activity of CASP3 protein
Curcumin results in decreased expression of CASP3 mRNA; Curcumin results in decreased expression of CASP3 protein
CTD PMID:15095415 PMID:15569404 PMID:16023083 PMID:16101141 PMID:17041101 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 increases expression ISO Curcumin results in increased expression of CASP4 mRNA CTD PMID:16101141 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
decreases expression
ISO [Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP7 protein
Curcumin results in increased expression of CASP7 protein
Curcumin results in decreased expression of CASP7 mRNA
CTD PMID:16023083 PMID:16101141 PMID:19373661 PMID:31628941 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
increases cleavage
decreases expression
ISO
EXP
Curcumin results in increased activity of CASP8 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]
Curcumin results in increased cleavage of CASP8 protein
Curcumin results in decreased expression of CASP8 mRNA; Curcumin results in decreased expression of CASP8 protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]; Curcumin results in increased cleavage of and results in increased activity of CASP8 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Curcumin results in increased cleavage of CASP8 protein]
CTD PMID:14555224 PMID:16173963 PMID:17096185 PMID:17148446 PMID:22523229 More... NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
increases activity
increases expression
increases cleavage
ISO
EXP
Curcumin results in decreased expression of CASP9 mRNA; Curcumin results in decreased expression of CASP9 protein
Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP9 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP9 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA]
Curcumin results in increased activity of CASP9 protein
Curcumin results in increased expression of CASP9 mRNA; Curcumin results in increased expression of CASP9 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CASP9 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein
Curcumin results in increased cleavage of CASP9 protein
[Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in increased expression of CASP9 protein]; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Doxorubicin co-treated with Curcumin] results in increased expression of CASP9 mRNA; [Paclitaxel co-treated with Calcitriol] promotes the reaction [Curcumin results in increased expression of CASP9 protein]; [Paclitaxel co-treated with Curcumin] promotes the reaction [Calcitriol results in increased expression of CASP9 protein]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]; Curcumin promotes the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein; Paclitaxel promotes the reaction [Curcumin results in increased expression of CASP9 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]
CTD PMID:14555224 PMID:16023083 PMID:16101141 PMID:17148446 PMID:17277231 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
ISO
EXP
[arsenite co-treated with Curcumin] results in increased expression of CAT protein; Curcumin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of CAT protein]; Curcumin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Vehicle Emissions promotes the reaction [Cisplatin results in decreased activity of CAT protein]]; Curcumin inhibits the reaction [Vehicle Emissions results in decreased activity of CAT protein]
Curcumin results in increased activity of CAT protein
Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT]; Curcumin metabolite inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; sodium arsenite inhibits the reaction [Curcumin results in increased activity of CAT protein]
Curcumin results in increased expression of CAT mRNA
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein]
CTD PMID:16770732 PMID:17076682 PMID:17351913 PMID:17461496 PMID:18299980 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO [[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; Curcumin binds to and results in decreased activity of CBR1 protein; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Curcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein] CTD PMID:25541467 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO Curcumin results in increased expression of CCAR1 protein CTD PMID:21594647 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
JBrowse link
G Ccdc116 coiled-coil domain containing 116 increases expression ISO Curcumin results in increased expression of CCDC116 mRNA CTD PMID:18200517 NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
increases expression
ISO
EXP
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]
Curcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 protein
Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]
Curcumin results in increased expression of CCL2 mRNA
CTD PMID:10925121 PMID:11053056 PMID:17198877 PMID:17666914 PMID:18403477 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of CCN2 mRNA; Curcumin results in decreased expression of CCN2 protein
IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; Lipopolysaccharides inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA]
CTD PMID:17965732 PMID:19764552 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein]
Curcumin results in decreased expression of CCNA2 protein
CTD PMID:23222814 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Curcumin results in decreased expression of CCNB1 mRNA; Curcumin results in decreased expression of CCNB1 protein CTD PMID:17148446 PMID:18719366 PMID:19401701 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression
increases degradation
ISO
EXP
[Curcumin co-treated with Isoflavones] results in decreased expression of CCND1 protein; calyculin A inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]
Curcumin results in increased expression of CCND1 mRNA
Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of CCND1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA]
Curcumin results in decreased expression of CCND1; Curcumin results in decreased expression of CCND1 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CCND1 protein
Curcumin analog results in decreased expression of CCND1 protein; Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein
CTD PMID:15486348 PMID:15489888 PMID:15738001 PMID:16023083 PMID:16219905 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein]
Curcumin results in decreased expression of CCND3 protein
CTD PMID:23222814 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions
increases degradation
ISO
EXP
Curcumin results in decreased expression of CCNE1 protein
Curcumin results in decreased expression of CCNE1 mRNA
Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of CCNE1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCNE1 protein]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein]
CTD PMID:17148446 PMID:18156803 PMID:18299980 PMID:36640941 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccpg1 cell cycle progression 1 increases expression ISO Curcumin results in increased expression of CCPG1 mRNA CTD PMID:17198877 NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO Curcumin results in decreased expression of CCR2 mRNA CTD PMID:18403477 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] CTD PMID:18180316 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd36 CD36 molecule decreases expression
increases expression
multiple interactions
ISO Curcumin results in decreased expression of CD36 mRNA
Curcumin results in increased expression of CD36 mRNA
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein]
Curcumin results in decreased expression of CD36 mRNA; Curcumin results in decreased expression of CD36 protein
CTD PMID:16713233 PMID:23386263 PMID:23603106 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cd40 CD40 molecule decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of CD40 mRNA
CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]
[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein
CTD PMID:16101141 PMID:27430728 PMID:35549587 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein CTD PMID:27430728 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd44 CD44 molecule increases expression ISO Curcumin results in increased expression of CD44 mRNA CTD PMID:15713895 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cd47 Cd47 molecule multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA] CTD PMID:18200517 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) decreases expression ISO Curcumin results in decreased expression of CD55 mRNA CTD PMID:17999991 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cdc14b cell division cycle 14B increases expression ISO Curcumin results in increased expression of CDC14B mRNA CTD PMID:17198877 NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO Curcumin results in decreased expression of CDC20 mRNA CTD PMID:22258452 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc25c cell division cycle 25C increases phosphorylation ISO Curcumin results in increased phosphorylation of CDC25C protein CTD PMID:19401701 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of CDH1 protein
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in decreased expression of CDH1 protein]
CTD PMID:19573523 PMID:25656647 PMID:26191140 PMID:34233590 PMID:36640941 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh11 cadherin 11 decreases expression ISO Curcumin results in decreased expression of CDH11 protein CTD PMID:18025290 NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
JBrowse link
G Cdh17 cadherin 17 decreases expression ISO Curcumin results in decreased expression of CDH17 mRNA CTD PMID:17198877 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO
EXP
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]
Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CDH2 protein]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]]
CTD PMID:26191140 PMID:34233590 PMID:35549587 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP
ISO
Curcumin results in decreased expression of CDK1 mRNA
Curcumin results in decreased expression of CDK1 mRNA; Curcumin results in decreased expression of CDK1 protein
CTD PMID:17148446 PMID:18299980 PMID:19401701 PMID:22258452 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein]
Curcumin results in decreased expression of CDK2 protein
Curcumin analog results in decreased expression of CDK2 mRNA; Curcumin results in decreased expression of CDK2 protein
CTD PMID:19501152 PMID:23222814 PMID:26409325 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Curcumin analog results in decreased expression of CDK4 mRNA; Curcumin results in decreased expression of CDK4 protein CTD PMID:18156803 PMID:24211270 PMID:26409325 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases expression ISO Curcumin analog results in decreased expression of CDK5 mRNA CTD PMID:26409325 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Curcumin results in decreased expression of CDK6 protein CTD PMID:18156803 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdk7 cyclin-dependent kinase 7 decreases expression ISO Curcumin analog results in decreased expression of CDK7 mRNA CTD PMID:26409325 NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
JBrowse link
G Cdk9 cyclin-dependent kinase 9 decreases expression ISO Curcumin analog results in decreased expression of CDK9 mRNA CTD PMID:26409325 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
decreases expression
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1A protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [piperine co-treated with Curcumin] results in decreased expression of CDKN1A protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein]
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]
Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA; Curcumin results in increased expression of CDKN1A protein
[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of CDKN1A protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein]
CTD PMID:15713895 PMID:15738001 PMID:17148446 PMID:17332326 PMID:17602960 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
decreases expression
ISO
EXP
Curcumin results in increased expression of CDKN1B mRNA; Curcumin results in increased expression of CDKN1B protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein]
[arsenic trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]
Curcumin results in decreased expression of CDKN1B protein
CTD PMID:15713895 PMID:17602960 PMID:18156803 PMID:18226269 PMID:18593936 More... NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression
increases expression
ISO Curcumin results in decreased expression of CDKN2A protein
Curcumin results in increased expression of CDKN2A protein
CTD PMID:17148446 PMID:18156803 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D decreases expression EXP Curcumin results in decreased expression of CDKN2D mRNA CTD PMID:18299980 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
JBrowse link
G Cdx2 caudal type homeo box 2 increases expression EXP
ISO
Curcumin results in increased expression of CDX2 mRNA CTD PMID:18299980 PMID:27237783 NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA] CTD PMID:19297423 PMID:28595985 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CEBPB mRNA] CTD PMID:18200517 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA] CTD PMID:18200517 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces3a carboxylesterase 3a multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES3 mRNA] CTD PMID:18200517 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]
Curcumin results in decreased expression of CFLAR protein
CTD PMID:16173963 PMID:16219905 PMID:23452621 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
affects localization
ISO [PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Curcumin analog inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid]
Curcumin results in increased activity of CFTR protein; Curcumin results in increased activity of CFTR protein mutant form
Curcumin affects the localization of CFTR protein mutant form
Curcumin affects the folding of and affects the localization of CFTR protein mutant form
CTD PMID:15105504 PMID:15280357 PMID:15582996 PMID:17178710 PMID:23978416 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chat choline O-acetyltransferase multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein] CTD PMID:21839772 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chek1 checkpoint kinase 1 decreases response to substance
multiple interactions
increases activity
increases phosphorylation
ISO CHEK1 protein results in decreased susceptibility to Curcumin
Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein]
Curcumin results in increased activity of CHEK1 protein
Curcumin results in increased phosphorylation of CHEK1 protein
CTD PMID:18602917 PMID:19401701 PMID:27996348 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation
ISO [Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein; Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein]
Curcumin results in increased phosphorylation of CHEK2 protein
CTD PMID:21134073 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA] CTD PMID:24952339 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions
decreases activity
ISO Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]
Curcumin results in decreased activity of CHUK protein
CTD PMID:15129424 PMID:15489888 PMID:16023083 PMID:16219905 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Ckb creatine kinase B multiple interactions EXP Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:21378372 PMID:29315967 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:21378372 PMID:29315967 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Clca4 chloride channel accessory 4 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CLCA4A mRNA] CTD PMID:18200517 NCBI chr 2:233,883,625...233,904,993
Ensembl chr 2:233,883,851...233,903,089
JBrowse link
G Clcn6 chloride voltage-gated channel 6 decreases expression ISO Curcumin results in decreased expression of CLCN6 mRNA CTD PMID:17198877 NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059
JBrowse link
G Cldn1 claudin 1 multiple interactions ISO Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein] CTD PMID:35817260 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Cldn2 claudin 2 multiple interactions EXP Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2] CTD PMID:25119790 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
EXP
ISO
Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]]
Curcumin analog inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]
Curcumin results in decreased expression of COL1A1 mRNA; Curcumin results in decreased expression of COL1A1 protein
CTD PMID:17355460 PMID:17434272 PMID:17531121 PMID:17602960 PMID:17965732 More... NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A2 mRNA] CTD PMID:18200517 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col27a1 collagen type XXVII alpha 1 chain increases expression EXP Curcumin results in increased expression of COL27A1 mRNA CTD PMID:18299980 NCBI chr 5:76,647,302...76,765,989
Ensembl chr 5:76,647,429...76,765,174
JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression
multiple interactions
ISO Curcumin results in increased expression of COL2A1 mRNA; Curcumin results in increased expression of COL2A1 protein
[resveratrol co-treated with Curcumin] results in increased expression of COL2A1 protein
CTD PMID:18321735 PMID:19889203 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA] CTD PMID:22683883 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col4a1 collagen type IV alpha 1 chain increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of COL4A1 mRNA
Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA]
CTD PMID:18200517 PMID:21594647 PMID:28700904 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Col4a2 collagen type IV alpha 2 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA] CTD PMID:18200517 NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
JBrowse link
G Col4a5 collagen type IV alpha 5 chain decreases expression ISO Curcumin results in decreased expression of COL4A5 mRNA CTD PMID:15713895 NCBI chr  X:105,118,762...105,322,699
Ensembl chr  X:105,118,820...105,322,692
JBrowse link
G Col5a1 collagen type V alpha 1 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A1 mRNA] CTD PMID:18200517 NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
JBrowse link
G Col5a2 collagen type V alpha 2 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA] CTD PMID:18200517 NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO Curcumin results in increased expression of CPT1A mRNA CTD PMID:19297423 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions
increases phosphorylation
EXP
ISO
Curcumin results in increased expression of CREB1 mRNA
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CREB1 protein]
Curcumin results in increased phosphorylation of CREB1 protein
CTD PMID:17022948 PMID:18299980 PMID:22911773 PMID:27966075 PMID:29723552 More... NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Creb3 cAMP responsive element binding protein 3 increases expression EXP Curcumin results in increased expression of CREB3 mRNA CTD PMID:18299980 NCBI chr 5:57,817,865...57,823,233
Ensembl chr 5:57,817,832...57,824,390
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]] CTD PMID:22258452 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crp C-reactive protein multiple interactions EXP
ISO
Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of CRP protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of CRP protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of CRP protein]
CTD PMID:21378372 PMID:26713546 PMID:30431687 PMID:31820278 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO
EXP
Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]
[Curcumin co-treated with arsenite] results in increased expression of CRYAB mRNA; [Curcumin co-treated with Cadmium Chloride] results in increased expression of CRYAB protein; Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]
CTD PMID:9764755 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Cs citrate synthase affects expression EXP Curcumin affects the expression of CS mRNA CTD PMID:18539377 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein] CTD PMID:15129424 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions
increases expression
ISO Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein]
Curcumin results in increased expression of CSF1R mRNA
CTD PMID:15129424 PMID:22714040 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha increases expression ISO Curcumin results in increased expression of CSF2RA mRNA CTD PMID:22714040 NCBI chr14:98,089...103,261
Ensembl chr14:89,172...103,128
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CSF2RB mRNA] CTD PMID:18200517 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
increases expression
multiple interactions
decreases phosphorylation
increases degradation
ISO
EXP
Curcumin analog results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 protein
Curcumin results in increased expression of CTNNB1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; Curcumin results in decreased phosphorylation of and affects the localization of CTNNB1 protein
Curcumin results in decreased phosphorylation of CTNNB1 protein
[piperine co-treated with Curcumin] results in decreased expression of CTNNB1 protein; Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CTNNB1 protein]
Curcumin analog results in increased degradation of CTNNB1 protein; Curcumin results in increased degradation of CTNNB1 protein
CTD PMID:10783313 PMID:17041101 PMID:19294764 PMID:19573523 PMID:25963729 More... NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsb cathepsin B multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]
Curcumin analog results in decreased expression of CTSB mRNA
CTD PMID:8534267 PMID:26409325 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]
Curcumin analog results in decreased expression of CTSD mRNA
CTD PMID:8534267 PMID:26409325 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctss cathepsin S decreases expression ISO Curcumin results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
decreases expression
ISO NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]
Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein
CTD PMID:17999991 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] CTD PMID:18660423 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO Curcumin results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of CXCL2 mRNA; Curcumin results in decreased expression of CXCL2 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA]
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]
CTD PMID:17999991 PMID:18001810 PMID:18200517 PMID:27194111 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]
CTD PMID:17999991 PMID:27194111 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO Curcumin results in increased expression of CXCR1 protein CTD PMID:12216086 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO Curcumin results in increased expression of CXCR2 protein CTD PMID:12216086 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of CXCR4 mRNA
Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]
CTD PMID:17198877 PMID:18660423 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO Curcumin affects the localization of CYCS protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CYCS protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased expression of CYCS protein
CTD PMID:19235267 PMID:27430728 PMID:33617879 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression
decreases activity
decreases expression
ISO
EXP
Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Curcumin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; decitabine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; trichostatin A affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA]
Curcumin results in increased activity of CYP1A1 protein
Curcumin results in increased expression of CYP1A1 mRNA
Curcumin results in decreased activity of CYP1A1 protein
Curcumin results in decreased expression of CYP1A1 mRNA
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:11454723 PMID:12628514 PMID:15841493 PMID:16288784 PMID:17012224 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
multiple interactions
ISO
EXP
Curcumin results in decreased activity of CYP1A2 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A2 mRNA]
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]
CTD PMID:15841493 PMID:16288784 PMID:18321868 PMID:34802538 PMID:35063475 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Curcumin results in decreased expression of CYP1B1 mRNA
CTD PMID:17637178 PMID:19018768 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA
Curcumin results in increased expression of CYP24A1 protein
CTD PMID:20153625 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression
multiple interactions
EXP Curcumin affects the expression of CYP2B1 protein
Curcumin inhibits the reaction [CYP2B1 protein results in increased metabolism of nitrosobenzylmethylamine]
CTD PMID:16805852 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 multiple interactions EXP Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2C9 protein] CTD PMID:16288784 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases expression ISO Curcumin results in decreased expression of CYP2D6 mRNA CTD PMID:33582110 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects expression
multiple interactions
increases expression
EXP
ISO
Curcumin affects the expression of CYP2E1 protein
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]
Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]
Curcumin results in increased expression of CYP2E1 mRNA
CTD PMID:16805852 PMID:18539377 PMID:24508477 PMID:30423402 PMID:33350580 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
multiple interactions
increases expression
ISO Curcumin results in decreased expression of CYP3A4 mRNA
[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
Curcumin results in increased expression of CYP3A4 mRNA
CTD PMID:17210444 PMID:17270371 PMID:17965521 PMID:18385293 PMID:20153625 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Curcumin results in increased expression of CYP4A3 mRNA CTD PMID:18539377 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
JBrowse link
G Cyth4 cytohesin 4 increases expression ISO Curcumin results in increased expression of CYTH4 mRNA CTD PMID:17198877 NCBI chr 7:110,152,232...110,176,726
Ensembl chr 7:110,152,272...110,176,741
JBrowse link
G Daxx death-domain associated protein increases expression ISO Curcumin results in increased expression of DAXX mRNA CTD PMID:16101141 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Dbn1 drebrin 1 multiple interactions EXP Curcumin inhibits the reaction [Glucose results in decreased expression of DBN1 mRNA] CTD PMID:23333261 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
JBrowse link
G Dcn decorin increases expression ISO Curcumin results in increased expression of DCN mRNA CTD PMID:21594647 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Dcx doublecortin multiple interactions
increases expression
EXP
ISO
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA]
Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DCX protein]
Curcumin results in increased expression of DCX mRNA
CTD PMID:25963729 PMID:32735850 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]
Curcumin results in increased expression of DDIT3 mRNA; Curcumin results in increased expression of DDIT3 protein
CTD PMID:16613838 PMID:17171638 PMID:18200517 PMID:18719366 PMID:21793155 More... NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like decreases expression
increases expression
ISO
EXP
Curcumin results in decreased expression of DDIT4L mRNA
Curcumin results in increased expression of DDIT4L mRNA
CTD PMID:17999991 PMID:18299980 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
JBrowse link
G Dffb DNA fragmentation factor subunit beta increases expression
decreases expression
ISO Curcumin results in increased expression of DFFB mRNA; Curcumin results in increased expression of DFFB protein
Curcumin results in decreased expression of DFFB protein
CTD PMID:21397623 PMID:22714040 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression
affects expression
EXP
ISO
Curcumin results in decreased expression of DHCR24 mRNA
Curcumin affects the expression of DHCR24 mRNA
CTD PMID:27208389 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects expression
decreases expression
ISO
EXP
Curcumin affects the expression of DHCR7 mRNA
Curcumin results in decreased expression of DHCR7 mRNA
CTD PMID:27208389 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G Dhrs1 dehydrogenase/reductase 1 decreases expression ISO Curcumin results in decreased expression of DHRS1 mRNA CTD PMID:17198877 NCBI chr15:29,236,522...29,243,807
Ensembl chr15:29,236,522...29,243,838
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization
multiple interactions
increases expression
increases response to substance
ISO Curcumin affects the localization of DIABLO protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein
Curcumin results in increased expression of DIABLO mRNA
DIABLO protein results in increased susceptibility to Curcumin
CTD PMID:17277231 PMID:23555722 PMID:27430728 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression
multiple interactions
EXP Curcumin results in decreased expression of DKK1 mRNA; Curcumin results in decreased expression of DKK1 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein]
CTD PMID:25963729 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DLG4 protein] CTD PMID:29723552 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Curcumin results in increased expression of DNAJB9 mRNA CTD PMID:17999991 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP Curcumin inhibits the reaction [Potassium Dichromate results in increased expression of DNM1L protein] CTD PMID:32980475 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression
affects expression
multiple interactions
increases activity
ISO Curcumin results in decreased expression of DNMT1 mRNA; Curcumin results in decreased expression of DNMT1 protein
Curcumin analog affects the expression of DNMT1 protein
Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]; Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein]
Curcumin analog results in decreased expression of DNMT1 protein
CTD PMID:23593078 PMID:26991801 PMID:27132804 PMID:29228771 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO Curcumin results in decreased expression of DNMT3A mRNA
Curcumin analog results in decreased expression of DNMT3A protein
CTD PMID:23593078 PMID:26991801 PMID:29228771 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO Curcumin results in decreased expression of DNMT3B mRNA
Curcumin analog results in decreased expression of DNMT3B protein
CTD PMID:23593078 PMID:26991801 PMID:29228771 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Dram1 DNA-damage regulated autophagy modulator 1 increases expression ISO Curcumin results in increased expression of DRAM1 mRNA CTD PMID:21594647 NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DRD2 protein] CTD PMID:27966075 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of DUSP1 mRNA
Curcumin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein]
CTD PMID:15713895 PMID:20885979 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Curcumin results in increased expression of DUSP10 mRNA CTD PMID:15713895 PMID:17151092 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Curcumin results in increased expression of DUSP5 mRNA CTD PMID:17198877 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 multiple interactions
decreases expression
increases expression
EXP
ISO
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 protein]
Curcumin results in decreased expression of DVL1 protein
Curcumin results in increased expression of DVL1 mRNA; Curcumin results in increased expression of DVL1 protein
CTD PMID:19573523 PMID:25963729 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
JBrowse link
G Dynll1 dynein light chain LC8-type 1 increases expression ISO Curcumin results in increased expression of DYNLL1 mRNA CTD PMID:17198877 NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases activity
multiple interactions
ISO Curcumin results in decreased activity of DYRK2 protein
[Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein
CTD PMID:33617879 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression EXP Curcumin results in decreased expression of E2F1 mRNA CTD PMID:18299980 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G E2f5 E2F transcription factor 5 decreases expression ISO Curcumin results in decreased expression of E2F5 mRNA CTD PMID:15713895 NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Curcumin results in increased expression of ECH1 mRNA CTD PMID:18539377 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Edaradd EDAR associated via death domain multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA] CTD PMID:23452621 NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447
JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 decreases expression ISO Curcumin results in decreased expression of EDIL3 mRNA CTD PMID:18421014 NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
JBrowse link
G Egf epidermal growth factor multiple interactions
decreases activity
ISO
EXP
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein]
Curcumin results in decreased activity of EGF protein
Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]
CTD PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:18214481 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases phosphorylation
decreases expression
ISO
EXP
Curcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein]; Curcumin results in decreased expression of and results in decreased activity of EGFR protein; Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein]; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein]
Curcumin results in decreased phosphorylation of EGFR protein
Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]
Curcumin analog results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein
CTD PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:17918158 More... NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
decreases expression
ISO
EXP
EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]; U 0126 inhibits the reaction [Curcumin results in increased expression of EGR1 protein]
Curcumin results in increased expression of EGR1 mRNA; Curcumin results in increased expression of EGR1 protein
Curcumin results in decreased expression of EGR1 mRNA
CTD PMID:17198877 PMID:17999991 PMID:18316600 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 decreases expression ISO Curcumin results in decreased expression of EIF1 mRNA CTD PMID:17999991 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases expression
decreases phosphorylation
ISO calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of EIF4EBP1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of EIF4EBP1 protein]
Curcumin results in decreased expression of EIF4EBP1 protein
CTD PMID:18790744 PMID:23222814 PMID:34634291 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 decreases phosphorylation ISO Curcumin results in decreased phosphorylation of EIF4G1 protein CTD PMID:18790744 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
JBrowse link
G Elf2 E74 like ETS transcription factor 2 decreases expression ISO Curcumin results in decreased expression of ELF2 mRNA CTD PMID:15713895 NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions
increases phosphorylation
ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ELK1 mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein] CTD PMID:18316600 PMID:23452621 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Emb embigin multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA] CTD PMID:18200517 NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
JBrowse link
G Eno1 enolase 1 decreases expression ISO Curcumin results in decreased expression of ENO1 mRNA CTD PMID:16880289 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 increases expression EXP Curcumin results in increased expression of ENTPD5 mRNA CTD PMID:18299980 NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions
decreases activity
decreases expression
affects localization
ISO
EXP
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]
Curcumin results in decreased activity of EP300 protein
Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]
Curcumin results in decreased expression of EP300 mRNA; Curcumin results in decreased expression of EP300 protein
CTD PMID:17927689 PMID:22228707 PMID:22258452 PMID:26612707 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:20554536 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions
decreases expression
ISO WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein]
Curcumin results in decreased expression of EPCAM mRNA; Curcumin results in decreased expression of EPCAM protein
CTD PMID:33539684 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Epo erythropoietin decreases expression ISO Curcumin results in decreased expression of EPO mRNA CTD PMID:16880289 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Epx eosinophil peroxidase multiple interactions ISO [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein] CTD PMID:34998855 NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
increases response to substance
increases degradation
decreases expression
ISO [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog promotes the reaction [Cycloheximide results in increased degradation of ERBB2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein
ERBB2 protein results in increased susceptibility to Curcumin; ERBB2 protein results in increased susceptibility to Curcumin analog
Curcumin analog results in increased degradation of ERBB2 protein
Curcumin analog results in decreased expression of ERBB2 mRNA; Curcumin analog results in decreased expression of ERBB2 protein; Curcumin results in decreased expression of ERBB2 mRNA; Curcumin results in decreased expression of ERBB2 protein
CTD PMID:17041101 PMID:17918158 PMID:18719366 PMID:25866362 PMID:26409325 More... NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression
ISO Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]
Curcumin analog results in decreased expression of ERBB3 mRNA; Curcumin results in decreased expression of ERBB3 mRNA
CTD PMID:15713895 PMID:17918158 PMID:26409325 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression
ISO
EXP
[Curcumin results in decreased expression of ERCC1 protein] which results in increased susceptibility to Cisplatin; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 protein]
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA]
Curcumin results in decreased expression of ERCC1 mRNA; Curcumin results in decreased expression of ERCC1 protein
CTD PMID:17596214 PMID:21493726 PMID:22228707 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA]
Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 protein]
Curcumin results in decreased expression of ERCC4 mRNA; Curcumin results in decreased expression of ERCC4 protein
CTD PMID:22228707 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases expression
increases expression
ISO Curcumin results in decreased expression of ERN1 mRNA
Curcumin results in increased expression of ERN1 mRNA
CTD PMID:17999991 PMID:29723631 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Curcumin inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein]
Curcumin results in decreased expression of ESR1 protein
CTD PMID:15899841 PMID:18347134 PMID:23222814 PMID:24211270 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor decreases expression ISO Curcumin results in decreased expression of ETS2 protein CTD PMID:17332326 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
JBrowse link
G F2 coagulation factor II, thrombin multiple interactions EXP Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein] CTD PMID:18565277 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA] CTD PMID:23452621 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA] CTD PMID:23452621 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fads1 fatty acid desaturase 1 affects expression
decreases expression
ISO
EXP
Curcumin affects the expression of FADS1 mRNA
Curcumin results in decreased expression of FADS1 mRNA
CTD PMID:27208389 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression
affects expression
EXP
ISO
Curcumin results in decreased expression of FADS2 mRNA
Curcumin affects the expression of FADS2 mRNA
CTD PMID:27208389 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Fam120b family with sequence similarity 120 member B decreases expression ISO Curcumin results in decreased expression of FAM120B mRNA CTD PMID:17999991 NCBI chr 1:56,320,015...56,385,064
Ensembl chr 1:56,339,129...56,385,061
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]
Curcumin results in decreased expression of FANCD2 mRNA
CTD PMID:24124520 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fanci FA complementation group I multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]
Curcumin results in decreased expression of FANCI mRNA
CTD PMID:24124520 NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in increased expression of FAS protein CTD PMID:27430728 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions
decreases expression
ISO
EXP
[arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA]
Curcumin results in decreased expression of FASLG mRNA
CTD PMID:10925121 PMID:16101141 PMID:17351739 PMID:23452621 PMID:27430728 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase affects expression
decreases expression
ISO
EXP
Curcumin affects the expression of FASN mRNA; Curcumin affects the expression of FASN protein
Curcumin results in decreased expression of FASN mRNA
CTD PMID:27208389 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbln2 fibulin 2 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FBLN2 mRNA] CTD PMID:18200517 NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948
JBrowse link
G Fcgr3a Fc gamma receptor 3A multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FCGR3A mRNA] CTD PMID:18200517 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression EXP Curcumin results in decreased expression of FDFT1 mRNA CTD PMID:27208389 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression
decreases expression
affects expression
ISO
EXP
Curcumin results in increased expression of FDPS mRNA
Curcumin results in decreased expression of FDPS mRNA
Curcumin affects the expression of FDPS mRNA
CTD PMID:16713233 PMID:27208389 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression
increases expression
ISO Curcumin results in decreased expression of FGF2 protein
Curcumin results in increased expression of FGF2 protein
CTD PMID:23555722 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf5 fibroblast growth factor 5 decreases expression ISO Curcumin results in decreased expression of FGF5 mRNA CTD PMID:27237783 NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO Curcumin results in decreased expression of FGFR2 mRNA CTD PMID:15713895 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Filip1l filamin A interacting protein 1-like increases expression ISO Curcumin results in increased expression of FILIP1L mRNA CTD PMID:21594647 NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein] CTD PMID:28698153 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein]
Curcumin results in decreased expression of FLT1 protein
CTD PMID:18593936 PMID:23845850 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
ISO
EXP
Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein]
Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
Curcumin results in decreased expression of FN1 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA]
CTD PMID:12388107 PMID:18200517 PMID:18555241 PMID:21998146 PMID:22228707 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fntb farnesyltransferase, CAAX box, beta increases expression ISO Curcumin results in increased expression of FNTB mRNA CTD PMID:17999991 NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
increases expression
ISO
EXP
Curcumin results in decreased expression of FOS mRNA
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of FOS protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FOS mRNA]
Curcumin results in increased expression of FOS mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
CTD PMID:15713895 PMID:17827730 PMID:17999991 PMID:23452621 PMID:26191140 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions
increases ubiquitination
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]
Curcumin results in increased ubiquitination of FOSL1 protein
CTD PMID:17148446 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO Curcumin results in decreased expression of FOSL2 mRNA
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein]
CTD PMID:17148446 PMID:17999991 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Foxa1 forkhead box A1 multiple interactions ISO Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]] CTD PMID:22258452 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G Foxa2 forkhead box A2 decreases expression ISO Curcumin results in decreased expression of FOXA2 mRNA CTD PMID:27237783 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
JBrowse link
G Foxf2 forkhead box F2 decreases expression ISO Curcumin results in decreased expression of FOXF2 mRNA CTD PMID:15713895 NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176
JBrowse link
G Foxo1 forkhead box O1 increases expression
decreases phosphorylation
ISO Curcumin results in increased expression of FOXO1 mRNA
Curcumin results in decreased phosphorylation of FOXO1 protein
CTD PMID:18403477 PMID:18790744 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein] CTD PMID:31199764 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fstl1 follistatin-like 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA] CTD PMID:18200517 NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
JBrowse link
G Ftl1 ferritin light chain 1 decreases expression ISO Curcumin results in decreased expression of FTL1 mRNA CTD PMID:24634837 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
JBrowse link
G Fus Fus RNA binding protein increases expression
decreases expression
ISO Curcumin results in increased expression of FUS mRNA
Curcumin results in decreased expression of FUS mRNA
CTD PMID:17198877 PMID:17999991 NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414
JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression ISO Curcumin results in decreased expression of FZD1 mRNA CTD PMID:15713895 NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 affects expression ISO Curcumin affects the expression of G6PC1 mRNA CTD PMID:27208389 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression
multiple interactions
EXP
ISO
Curcumin results in increased expression of G6PD mRNA; Curcumin results in increased expression of G6PDX mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of G6PD protein]
CTD PMID:18299980 PMID:36924976 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression EXP Curcumin results in decreased expression of GABRA1 mRNA CTD PMID:18299980 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP Curcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA] CTD PMID:23267840 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP
ISO
Curcumin results in increased expression of GADD45A mRNA CTD PMID:16101141 PMID:18299980 PMID:18719366 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gas6 growth arrest specific 6 increases expression ISO Curcumin results in increased expression of GAS6 mRNA CTD PMID:21594647 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA] CTD PMID:22258452 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO Curcumin results in decreased expression of GATA4 mRNA; Curcumin results in decreased expression of GATA4 protein CTD PMID:27237783 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
multiple interactions
increases expression
ISO
EXP
Curcumin results in increased activity of GCLC protein
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of GCLC mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLC protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin analog results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC mRNA
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC protein
Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC protein]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein]; Curcumin results in increased activity of [GCLC protein binds to GCLM protein]
CTD PMID:10514034 PMID:17602960 PMID:18299980 PMID:18332871 PMID:19168576 More... NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
EXP
ISO
Curcumin results in increased activity of [GCLC protein binds to GCLM protein]
Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLM mRNA]
Curcumin analog results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM protein
NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]
CTD PMID:17198877 PMID:17535857 PMID:17602960 PMID:17999991 PMID:18332871 More... NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gda guanine deaminase multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GDA mRNA] CTD PMID:18200517 NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of GFAP mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of GFAP mRNA]
CTD PMID:19555370 PMID:25963729 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression
multiple interactions
EXP Curcumin results in increased expression of GGT1 mRNA
Curcumin inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]
CTD PMID:18299980 PMID:24704557 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Ggta1 glycoprotein alpha-galactosyltransferase 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GGTA1 mRNA] CTD PMID:18200517 NCBI chr 3:18,732,985...18,824,916
Ensembl chr 3:18,732,991...18,809,908
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA] CTD PMID:23452621 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of GLI1 mRNA; Curcumin results in decreased expression of GLI1 protein
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of GLI1 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI1 protein]
CTD PMID:20395211 PMID:31612257 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions EXP Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]] CTD PMID:31612257 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO Curcumin results in decreased activity of GLO1 protein CTD PMID:18946510 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [Iron results in increased activity of GOT1 protein] CTD PMID:16956363 PMID:36037877 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Got1l1 glutamic-oxaloacetic transaminase 1-like 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GOT1L1 mRNA] CTD PMID:18200517 NCBI chr16:64,860,308...64,873,656
Ensembl chr16:64,860,704...64,866,162
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression
affects expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of GPAM mRNA
Curcumin affects the expression of GPAM mRNA
Curcumin inhibits the reaction [Dietary Fats results in increased expression of GPAM mRNA]
CTD PMID:19297423 PMID:27208389 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 decreases expression ISO Curcumin results in decreased expression of GPER1 mRNA CTD PMID:17198877 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
G Gphn gephyrin affects expression EXP Curcumin affects the expression of GPHN mRNA CTD PMID:18539377 NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [Acetaminophen affects the activity of GPT protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GPT protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased activity of GPT protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of GPT protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GPT protein]; Curcumin inhibits the reaction [Iron results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [bisphenol A results in increased activity of GPT protein]; Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of GPT protein]
CTD PMID:16956363 PMID:20804811 PMID:24704557 PMID:25123790 PMID:27288928 More... NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
multiple interactions
EXP
ISO
Curcumin results in decreased expression of GPX1 mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of GPX1 protein]
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]
CTD PMID:18299980 PMID:19914224 PMID:23267840 PMID:30934151 PMID:36924976 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Grb10 growth factor receptor bound protein 10 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA] CTD PMID:18200517 NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO Curcumin analog results in decreased expression of GRB2 mRNA CTD PMID:26409325 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA] CTD PMID:18200517 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 multiple interactions EXP Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein] CTD PMID:23267840 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein] CTD PMID:23267840 PMID:29723552 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2A protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A protein] CTD PMID:25496357 PMID:29723552 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2B protein] CTD PMID:25496357 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grm2 glutamate metabotropic receptor 2 decreases expression ISO Curcumin results in decreased expression of GRM2 protein CTD PMID:25406541 NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of GSDMD protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD protein] CTD PMID:34998855 PMID:35063475 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
decreases expression
multiple interactions
increases phosphorylation
increases expression
ISO
EXP
Curcumin results in decreased phosphorylation of GSK3B protein
Curcumin results in decreased expression of GSK3B mRNA
Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin results in increased expression of and results in increased phosphorylation of GSK3B protein
Curcumin results in increased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of GSK3B mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]
Curcumin results in increased expression of GSK3B protein
CTD PMID:18006147 PMID:18790744 PMID:19573523 PMID:25541178 PMID:25963729 More... NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsn gelsolin multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GSN mRNA] CTD PMID:18200517 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of GSR mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of GSR protein]
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GSR]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of GSR protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]
CTD PMID:19168576 PMID:19914224 PMID:20593964 PMID:21976817 PMID:24347089 More... NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gss glutathione synthetase increases expression
multiple interactions
ISO Curcumin results in increased expression of GSS mRNA
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GSS mRNA]
CTD PMID:19183254 PMID:35063475 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases activity ISO Curcumin results in increased activity of GSTA4 protein CTD PMID:10514034 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Curcumin results in increased expression of GSTA5 mRNA CTD PMID:18299980 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions ISO Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GSTK1 mRNA] CTD PMID:31521693 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of GSTO1 mRNA
Curcumin promotes the reaction [sodium arsenite results in increased expression of GSTO1 mRNA]
CTD PMID:34272803 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
affects expression
increases expression
decreases expression
ISO
EXP
[sulfinosine co-treated with Curcumin] results in decreased expression of GSTP1 mRNA; Curcumin binds to and results in decreased activity of GSTP1 protein; Curcumin inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA]
Curcumin affects the expression of GSTP1 protein
Curcumin results in increased expression of GSTP1 mRNA
Curcumin results in decreased expression of GSTP1 mRNA; Curcumin results in decreased expression of GSTP1 protein
Curcumin results in increased expression of GSTP1 mRNA; Curcumin results in increased expression of GSTP1 protein
CTD PMID:9463521 PMID:14555224 PMID:14742295 PMID:15999103 PMID:16101141 More... NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP Curcumin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:8534267 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G H19 H19 imprinted maternally expressed transcript decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of H19 mRNA
curcumin inhibits the reaction [platelet- derived growth factor increases expression of H19 RNA in aortic vascular smooth muscle cells]
curcumin inhibits the reaction [carotid balloon injury increases expression of H19 RNA in carotid artery segment]
CTD
RGD
PMID:18348204 PMID:34487706 PMID:34487706 RGD:156430326, RGD:156430326 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
JBrowse link
G H1f10 H1.10 linker histone decreases expression ISO Curcumin results in decreased expression of H1-10 mRNA CTD PMID:17198877 NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO [Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein
Curcumin results in increased phosphorylation of H2AX protein
CTD PMID:19401701 PMID:21134073 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G H2bu1 H2B.U histone 1 increases expression ISO Curcumin results in increased expression of H2BC26 mRNA CTD PMID:15713895 NCBI chr10:43,732,737...43,733,484
Ensembl chr10:43,732,864...43,736,277
JBrowse link
G H3f4 H3.4 histone, cluster member increases acetylation
increases phosphorylation
EXP Curcumin results in increased acetylation of H3F4 protein
Curcumin results in increased phosphorylation of H3F4 protein
CTD PMID:18204486 NCBI chr10:43,740,702...43,741,262 JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Curcumin results in decreased expression of HAMP mRNA CTD PMID:24634837 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hand1 heart and neural crest derivatives expressed 1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Alcohols results in increased expression of HAND1 mRNA]
Curcumin results in decreased expression of HAND1 mRNA
CTD PMID:24857828 NCBI chr10:42,006,646...42,009,213
Ensembl chr10:42,006,651...42,009,213
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Alcohols results in increased expression of HAND2 mRNA]
Curcumin results in decreased expression of HAND2 mRNA
CTD PMID:24857828 NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased export of HAVCR1 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [maleic acid results in increased expression of HAVCR1 protein] CTD PMID:25119790 PMID:29421648 PMID:30431687 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hbs1l HBS1-like translational GTPase decreases expression ISO Curcumin results in decreased expression of HBS1L mRNA CTD PMID:18421014 NCBI chr 1:16,092,529...16,170,082
Ensembl chr 1:16,092,547...16,170,074
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases activity
multiple interactions
ISO Curcumin analog results in decreased activity of HCK protein
[Curcumin binds to 3,4,5-trimethoxybenzaldehyde] which results in decreased activity of HCK protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [HCK protein binds to Adenosine Triphosphate]; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which binds to and results in decreased phosphorylation of and results in decreased activity of HCK protein
CTD PMID:33617879 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions
decreases expression
affects localization
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein]
Curcumin analog results in decreased expression of HDAC1 protein
Curcumin analog results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 protein
CTD PMID:17927689 PMID:18161303 PMID:23593078 PMID:26409325 PMID:29228771 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hdac11 histone deacetylase 11 decreases expression ISO Curcumin analog results in decreased expression of HDAC11 mRNA CTD PMID:26409325 NCBI chr 4:123,645,873...123,667,407
Ensembl chr 4:123,650,157...123,667,405
JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein]
Curcumin analog results in decreased expression of HDAC2 mRNA
CTD PMID:18421014 PMID:26409325 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac3 histone deacetylase 3 decreases expression ISO Curcumin results in decreased expression of HDAC3 protein CTD PMID:17927689 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Hdac4 histone deacetylase 4 decreases expression ISO Curcumin analog results in decreased expression of HDAC4 mRNA
Curcumin analog results in decreased expression of HDAC4 protein
CTD PMID:26409325 PMID:26991801 PMID:29228771 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
JBrowse link
G Hdac6 histone deacetylase 6 decreases expression ISO Curcumin analog results in decreased expression of HDAC6 mRNA CTD PMID:26409325 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441
JBrowse link
G Hdac7 histone deacetylase 7 decreases expression ISO Curcumin analog results in decreased expression of HDAC7 protein CTD PMID:29228771 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072
JBrowse link
G Hdac8 histone deacetylase 8 decreases expression ISO Curcumin analog results in decreased expression of HDAC8 mRNA CTD PMID:26409325 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923
JBrowse link
G Hebp2 heme binding protein 2 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HEBP2 mRNA] CTD PMID:18200517 NCBI chr 1:13,194,982...13,201,777
Ensembl chr 1:13,194,982...13,201,777
JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions ISO [1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of HES1 mRNA CTD PMID:22982865 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hgf hepatocyte growth factor increases expression
decreases expression
ISO Curcumin results in increased expression of HGF protein
Curcumin results in decreased expression of HGF protein
CTD PMID:23555722 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
decreases activity
ISO
EXP
[Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein modified form]; Curcumin analog inhibits the reaction [Ionomycin promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; Curcumin analog inhibits the reaction [Ionomycin results in increased activity of HIF1A protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of HIF1A protein]; Curcumin results in decreased expression of and results in decreased activity of HIF1A protein; VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A protein]
Curcumin results in decreased expression of HIF1A mRNA
Curcumin analog results in decreased expression of HIF1A mRNA; Curcumin results in decreased expression of HIF1A mRNA
Curcumin results in decreased activity of HIF1A protein
CTD PMID:16880289 PMID:18682687 PMID:20554536 PMID:21397623 PMID:23845850 More... NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hist1h2bd histone cluster 1 H2B family member D increases expression ISO Curcumin results in increased expression of H2BC5 mRNA CTD PMID:17999991 NCBI chr17:42,792,887...42,793,268 JBrowse link
G Hist1h2bq histone cluster 1 H2B family member Q increases expression EXP Curcumin results in increased expression of HIST1H2BQ mRNA CTD PMID:18299980 NCBI chr17:41,432,100...41,441,487
Ensembl chr17:41,429,164...41,442,153
JBrowse link
G Hk1 hexokinase 1 multiple interactions ISO Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of HK1 protein] CTD PMID:36924976 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
JBrowse link
G Hk2 hexokinase 2 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of HK2 protein
4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; Curcumin promotes the reaction [Sirolimus results in decreased expression of HK2 protein]
CTD PMID:36640941 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein] CTD PMID:22683883 PMID:29480285 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
multiple interactions
decreases expression
affects expression
ISO
EXP
Curcumin results in increased expression of HMGCR mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of HMGCR protein]
Curcumin results in decreased expression of HMGCR mRNA
Curcumin affects the expression of HMGCR mRNA; Curcumin affects the expression of HMGCR protein
CTD PMID:16713233 PMID:27208389 PMID:37701206 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression EXP Curcumin results in decreased expression of HMGCS1 mRNA CTD PMID:27208389 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression
decreases response to substance
increases activity
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [quinocetone results in increased activity of HMOX1 protein]; Curcumin promotes the reaction [quinocetone results in increased expression of HMOX1 mRNA]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; Cycloheximide inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Egtazic Acid inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Go 6976 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; MAPK14 protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCA protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCD protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein]
Curcumin results in decreased expression of HMOX1 mRNA
Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein
[chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Chloranil] results in increased expression of HMOX1 protein; [Curcumin co-treated with piperine] results in increased expression of HMOX1 mRNA; [Curcumin co-treated with piperine] results in increased expression of HMOX1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[Curcumin co-treated with piperine] results in increased expression of HMOX1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form affects the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]
Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein
HMOX1 protein results in decreased susceptibility to Curcumin
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]]; [Curcumin co-treated with Fructose] results in increased expression of HMOX1 protein; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Atrazine results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Ethanol results in decreased activity of HMOX1 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]]; Quartz promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein]
CTD PMID:10925121 PMID:14742295 PMID:17464175 PMID:17535857 PMID:17627722 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression ISO Curcumin results in decreased expression of HNRNPA1 mRNA CTD PMID:17999991 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D decreases expression ISO Curcumin results in decreased expression of HNRNPD mRNA CTD PMID:17999991 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
JBrowse link
G Hopx HOP homeobox increases expression EXP Curcumin results in increased expression of HOPX mRNA CTD PMID:18299980 NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909
JBrowse link
G Hoxb5 homeo box B5 increases expression ISO Curcumin results in increased expression of HOXB5 mRNA CTD PMID:18421014 NCBI chr10:81,269,372...81,271,580
Ensembl chr10:81,269,372...81,271,580
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression ISO Curcumin results in increased expression of HPRT1 mRNA CTD PMID:16101141 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions EXP
ISO
[arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein
Curcumin promotes the reaction [HSF1 protein binds to HSF1 protein]
CTD PMID:9764755 PMID:11322385 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression ISO Curcumin analog results in decreased expression of HSP90AA1 mRNA CTD PMID:26409325 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSP90AB1 mRNA] CTD PMID:26361869 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression ISO Curcumin analog results in decreased expression of HSP90B1 mRNA CTD PMID:26409325 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
decreases expression
ISO
EXP
Curcumin results in increased expression of HSPA1A mRNA; Curcumin results in increased expression of HSPA1A protein
Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPA1A mRNA]
Curcumin results in decreased expression of HSPA1A protein
CTD PMID:23555722 PMID:26361869 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO Curcumin results in increased expression of HSPA4 mRNA; Curcumin results in increased expression of HSPA4 protein CTD PMID:11322385 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
decreases expression
multiple interactions
ISO Curcumin results in increased expression of HSPA5 mRNA
Curcumin results in decreased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of HSPA5 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of HSPA5 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]
CTD PMID:18200517 PMID:27996348 PMID:29723631 PMID:36640941 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions EXP Curcumin inhibits the reaction [Streptozocin results in increased expression of HSPB1 protein]; Curcumin promotes the reaction [Isoproterenol results in increased expression of HSPB1 protein] CTD PMID:18204486 PMID:20125031 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspb7 heat shock protein family B (small) member 7 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HSPB7 mRNA] CTD PMID:18200517 NCBI chr 5:153,727,782...153,731,268
Ensembl chr 5:153,727,588...153,731,266
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP
ISO
Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPD1 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of HSPD1 protein
CTD PMID:26361869 PMID:27430728 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A affects expression EXP Curcumin affects the expression of HTR1A mRNA CTD PMID:17617388 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
affects expression
ISO
EXP
[Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Curcumin analog inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of ICAM1 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]
[chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Gemcitabine] results in decreased expression of ICAM1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 mRNA]
Curcumin results in decreased expression of ICAM1 protein
Curcumin affects the expression of ICAM1 mRNA
CTD PMID:16219905 PMID:16243823 PMID:17440100 PMID:17666914 PMID:17973899 More... NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO Curcumin results in decreased expression of ID1 mRNA CTD PMID:21594647 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Curcumin results in decreased expression of ID2 mRNA CTD PMID:21594647 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Curcumin results in decreased expression of ID3 mRNA CTD PMID:21594647 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 decreases expression ISO Curcumin results in decreased expression of IDO1 mRNA CTD PMID:18348204 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Ifna1 interferon, alpha 1 multiple interactions ISO Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNA1 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein] CTD PMID:17979888 PMID:23452621 NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 multiple interactions ISO Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein] CTD PMID:17979888 NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979
JBrowse link
G Ifnar2 interferon alpha and beta receptor subunit 2 multiple interactions ISO Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein] CTD PMID:17979888 NCBI chr11:30,613,576...30,645,958
Ensembl chr11:30,613,767...30,668,124
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein] CTD PMID:17979888 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma multiple interactions
increases secretion
ISO
EXP
Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNG mRNA]
[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IFNG mRNA]; tin protoporphyrin IX inhibits the reaction [[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]
Curcumin results in increased secretion of IFNG protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IFNG protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]
CTD PMID:16782535 PMID:16867261 PMID:16959222 PMID:18006644 PMID:22714040 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifnk interferon kappa decreases expression ISO Curcumin results in decreased expression of IFNK mRNA CTD PMID:18421014 NCBI chr 5:49,732,073...49,734,281
Ensembl chr 5:49,732,073...49,734,281
JBrowse link
G Igf1 insulin-like growth factor 1 decreases activity
multiple interactions
decreases expression
decreases secretion
ISO Curcumin results in decreased activity of IGF1 protein
Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]
Curcumin analog results in decreased expression of IGF1 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 mRNA]
Curcumin results in decreased secretion of IGF1 protein
CTD PMID:17458902 PMID:17499312 PMID:18200517 PMID:26409325 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of IGF1R protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein]
Curcumin analog results in decreased expression of IGF1R mRNA; Curcumin results in decreased expression of IGF1R mRNA
CTD PMID:17499312 PMID:17918158 PMID:26409325 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igf2 insulin-like growth factor 2 decreases expression
multiple interactions
ISO Curcumin analog results in decreased expression of IGF2 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGF2 protein
CTD PMID:26409325 PMID:27430728 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP1 protein CTD PMID:27430728 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP2 protein CTD PMID:27430728 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression
multiple interactions
increases secretion
increases expression
ISO
EXP
Curcumin results in decreased expression of IGFBP3 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP3 protein
Curcumin results in increased secretion of IGFBP3 protein
Curcumin results in increased expression of IGFBP3 mRNA
CTD PMID:16101141 PMID:17499312 PMID:18299980 PMID:21594647 PMID:27430728 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP4 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP4 protein
CTD PMID:18200517 PMID:27430728 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP5 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP5 protein
CTD PMID:18200517 PMID:27430728 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 increases expression ISO Curcumin results in increased expression of IGFBP7 mRNA CTD PMID:21594647 NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
decreases activity
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of IKBKB protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]
Curcumin results in decreased activity of IKBKB protein
CTD PMID:16023083 PMID:16219905 PMID:16678799 PMID:17965732 PMID:20054000 More... NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKG mRNA] CTD PMID:23452621 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
ISO
EXP
Curcumin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein]
Curcumin results in decreased expression of IL10 protein
CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Methotrexate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]
CTD PMID:15604057 PMID:16867261 PMID:17979888 PMID:20885979 PMID:21397623 More... NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA] CTD PMID:23452621 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions EXP
ISO
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12B mRNA]
CTD PMID:16867261 PMID:23452621 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL17A protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL17A mRNA] CTD PMID:34998855 PMID:35716765 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL18 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL18 protein]
Curcumin results in decreased expression of IL18 mRNA
Curcumin results in decreased expression of IL18 mRNA; Curcumin results in decreased expression of IL18 protein
CTD PMID:16368150 PMID:16751071 PMID:17399992 PMID:35063475 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO
EXP
Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein]
Curcumin inhibits the reaction [Soot results in increased secretion of IL1A protein]
CTD PMID:18719352 PMID:19782127 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta affects expression
multiple interactions
decreases expression
ISO
EXP
Curcumin affects the expression of IL1B mRNA
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of and results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL1B mRNA]
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL1B protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of IL1B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL1B mRNA]
[Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Soot results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]]
CTD PMID:15604057 PMID:15793857 PMID:16751071 PMID:16782535 PMID:16819191 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Curcumin results in decreased expression of and results in decreased secretion of IL2 protein CTD PMID:19761891 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions EXP Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2RA protein] CTD PMID:18340409 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 protein]
Curcumin results in decreased expression of IL4 protein
CTD PMID:16782535 PMID:16867261 PMID:21397623 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein] CTD PMID:34998855 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
increases expression
affects expression
ISO
EXP
Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL6 mRNA]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL6 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IL6 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL6 mRNA]
Curcumin results in increased expression of IL6 protein
Curcumin results in increased expression of IL6 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL6 protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Soot results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]
Curcumin affects the expression of IL6 mRNA; Curcumin affects the expression of IL6 protein
CTD PMID:16751071 PMID:17151092 PMID:17273796 PMID:17383825 PMID:17999991 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor multiple interactions ISO Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6R protein] CTD PMID:34233590 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer multiple interactions ISO Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6ST protein] CTD PMID:34233590 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
JBrowse link
G Ins1 insulin 1 multiple interactions EXP
ISO
Curcumin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
Curcumin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]
CTD PMID:23267840 PMID:25541178 PMID:27208389 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Ins2 insulin 2 multiple interactions EXP
ISO
Curcumin inhibits the reaction [Fructose results in increased expression of INS protein]
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]]
CTD PMID:25268984 PMID:26713546 PMID:28595985 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insig2 insulin induced gene 2 multiple interactions ISO Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA] CTD PMID:18704882 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link
G Insr insulin receptor multiple interactions ISO Curcumin inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form] CTD PMID:29793316 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irag2 inositol 1,4,5-triphosphate receptor associated 2 decreases expression ISO Curcumin results in decreased expression of IRAG2 mRNA CTD PMID:17198877 NCBI chr 4:178,088,902...178,143,569
Ensembl chr 4:178,088,507...178,143,557
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]
CTD PMID:16678799 PMID:23452621 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK2 mRNA] CTD PMID:23452621 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein] CTD PMID:16678799 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Irf5 interferon regulatory factor 5 increases expression ISO Curcumin analog results in increased expression of IRF5 mRNA CTD PMID:26409325 NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
affects phosphorylation
EXP
ISO
Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein]
Curcumin inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form]
Curcumin affects the phosphorylation of IRS1 protein
CTD PMID:26713546 PMID:27208389 PMID:29793316 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Irs2 insulin receptor substrate 2 affects phosphorylation ISO Curcumin affects the phosphorylation of IRS2 protein CTD PMID:27208389 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions EXP Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein] CTD PMID:18565277 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
JBrowse link
G Itgam integrin subunit alpha M multiple interactions
increases expression
ISO Calcitriol promotes the reaction [Curcumin results in increased expression of ITGAM]; Tretinoin promotes the reaction [Curcumin results in increased expression of ITGAM] CTD PMID:9112257 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]
Curcumin results in increased expression of ITGB1 protein
CTD PMID:17291458 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions EXP Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein] CTD PMID:18565277 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Itm2a integral membrane protein 2A multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ITM2A mRNA] CTD PMID:18200517 NCBI chr  X:72,486,383...72,492,344
Ensembl chr  X:72,486,381...72,492,363
JBrowse link
G Ivl involucrin multiple interactions ISO Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IVL mRNA] CTD PMID:17148446 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Jak2 Janus kinase 2 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of JAK2 protein
Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of JAK2 protein]
CTD PMID:16959222 PMID:34233590 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jak3 Janus kinase 3 decreases activity ISO Curcumin results in decreased activity of JAK3 protein CTD PMID:16932349 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation
multiple interactions
increases expression
decreases activity
ISO
EXP
Curcumin results in decreased phosphorylation of JUN protein
Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [benzyl isothiocyanate results in increased expression of and results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of JUN mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein]
Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of JUN protein]
Curcumin results in increased expression of JUN mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]
Curcumin results in decreased activity of JUN protein
CTD PMID:11035063 PMID:15713895 PMID:17148446 PMID:17458902 PMID:17596214 More... NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases ubiquitination
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein]
Curcumin results in increased ubiquitination of JUNB protein
CTD PMID:17148446 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUND protein] CTD PMID:17148446 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Curcumin results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnmb2 potassium calcium-activated channel subfamily M regulatory beta subunit 2 decreases expression ISO Curcumin results in decreased expression of KCNMB2 mRNA CTD PMID:17198877 NCBI chr 2:114,670,027...114,975,374
Ensembl chr 2:114,935,976...114,975,173
JBrowse link
G Kdr kinase insert domain receptor affects expression
multiple interactions
ISO
EXP
Curcumin affects the expression of KDR mRNA
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR protein]
Curcumin inhibits the reaction [Dietary Fats results in increased expression of KDR mRNA]
CTD PMID:17960570 PMID:19297423 PMID:23845850 PMID:35752269 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
decreases expression
increases expression
ISO
EXP
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 protein]; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]
Curcumin results in decreased expression of KEAP1 mRNA
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 mRNA]
Curcumin analog results in decreased expression of KEAP1 protein; Curcumin results in decreased expression of KEAP1 protein
Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]
Curcumin results in increased expression of KEAP1 mRNA
CTD PMID:17535857 PMID:23710286 PMID:26991801 PMID:30946834 PMID:31521693 More... NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions EXP [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of KIT protein CTD PMID:26612707 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Klf10 KLF transcription factor 10 decreases expression ISO Curcumin results in decreased expression of KLF10 mRNA CTD PMID:17999991 NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
JBrowse link
G Klf6 KLF transcription factor 6 increases expression ISO Curcumin results in increased expression of KLF6 mRNA CTD PMID:15713895 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
JBrowse link
G Klhl21 kelch-like family member 21 increases expression ISO Curcumin results in increased expression of KLHL21 mRNA CTD PMID:17198877 NCBI chr 5:162,514,888...162,523,545
Ensembl chr 5:162,514,765...162,523,545
JBrowse link
G Klhl24 kelch-like family member 24 decreases expression ISO Curcumin results in decreased expression of KLHL24 mRNA CTD PMID:17198877 NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636
JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of KLK3 mRNA; Curcumin results in decreased expression of KLK3 protein
Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 protein]; Curcumin results in decreased expression of and results in decreased secretion of KLK3 protein; trichostatin A inhibits the reaction [Curcumin results in decreased expression of KLK3 mRNA]
CTD PMID:12497104 PMID:18676361 PMID:18719366 PMID:21134073 PMID:22258452 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
JBrowse link
G Kmt5a lysine methyltransferase 5A decreases expression ISO Curcumin results in decreased expression of KMT5A mRNA; Curcumin results in decreased expression of KMT5A protein CTD PMID:25256401 NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases expression
multiple interactions
ISO Curcumin analog results in decreased expression of KRAS mRNA; Curcumin results in decreased expression of KRAS mRNA
Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein]
CTD PMID:17041101 PMID:21519798 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krtap2-1 keratin associated protein 2-1 decreases expression ISO Curcumin results in decreased expression of KRTAP2-1 mRNA CTD PMID:17999991 NCBI chr10:84,572,164...84,572,587
Ensembl chr10:84,572,164...84,572,556
JBrowse link
G Kynu kynureninase increases expression ISO Curcumin results in increased expression of KYNU mRNA CTD PMID:18421014 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 affects expression EXP Curcumin affects the expression of LAMP1 mRNA CTD PMID:18539377 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Lbp lipopolysaccharide binding protein multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LBP mRNA] CTD PMID:18200517 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO
EXP
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA]
Curcumin inhibits the reaction [Cadmium Chloride results in increased export of LCN2 protein]; Curcumin inhibits the reaction [maleic acid results in increased secretion of LCN2 protein]
CTD PMID:18200517 PMID:25119790 PMID:29421648 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNA] CTD PMID:18200517 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 increases expression ISO Curcumin results in increased expression of LCP2 mRNA CTD PMID:17198877 NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
decreases expression
ISO ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of LDHA protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of LDHA protein] CTD PMID:36640941 PMID:36924976 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
affects expression
increases expression
ISO Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]; Curcumin results in increased expression of and results in increased activity of LDLR protein
Curcumin affects the expression of LDLR mRNA
Curcumin results in increased expression of LDLR mRNA; Curcumin results in increased expression of LDLR protein
CTD PMID:16713233 PMID:16963807 PMID:18704882 PMID:27208389 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 increases expression
multiple interactions
EXP Curcumin results in increased expression of LEF1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of LEF1 mRNA]
CTD PMID:25963729 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Lgmn legumain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LGMN mRNA] CTD PMID:18200517 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of LHB protein] CTD PMID:31199764 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lhx5 LIM homeobox 5 affects expression EXP Curcumin affects the expression of LHX5 mRNA CTD PMID:18539377 NCBI chr12:36,126,186...36,134,625
Ensembl chr12:36,126,186...36,134,625
JBrowse link
G Lig3 DNA ligase 3 multiple interactions ISO Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 protein] CTD PMID:21332098 NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414
JBrowse link
G Lig4 DNA ligase 4 multiple interactions ISO Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 protein] CTD PMID:21332098 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040
JBrowse link
G Lipc lipase C, hepatic type affects expression ISO Curcumin affects the expression of LIPC mRNA CTD PMID:27208389 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Lox lysyl oxidase multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LOX mRNA] CTD PMID:18200517 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 decreases expression ISO Curcumin results in decreased expression of LPAR1 mRNA CTD PMID:17999991 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895
JBrowse link
G Lpl lipoprotein lipase affects expression ISO Curcumin affects the expression of LPL mRNA CTD PMID:27208389 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP5 mRNA]
Curcumin results in increased expression of LRP5 mRNA
CTD PMID:25963729 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
JBrowse link
G Lrp6 LDL receptor related protein 6 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP6 mRNA]
Curcumin results in increased expression of LRP6 mRNA
CTD PMID:25963729 NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
G Lrrn3 leucine rich repeat neuronal 3 increases expression ISO Curcumin results in increased expression of LRRN3 mRNA CTD PMID:17198877 NCBI chr 6:58,489,060...58,520,322
Ensembl chr 6:58,489,010...58,520,330
JBrowse link
G Lss lanosterol synthase affects expression
decreases expression
ISO
EXP
Curcumin affects the expression of LSS mRNA
Curcumin results in decreased expression of LSS mRNA
CTD PMID:27208389 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Lta lymphotoxin alpha decreases expression
multiple interactions
increases expression
ISO Curcumin results in decreased expression of LTA mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of LTA protein
Curcumin results in increased expression of LTA mRNA
CTD PMID:16101141 PMID:17198877 PMID:27430728 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
JBrowse link
G Ltb lymphotoxin beta increases expression
decreases expression
ISO Curcumin results in increased expression of LTB mRNA
Curcumin results in decreased expression of LTB mRNA
CTD PMID:16751071 PMID:17198877 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Ltbr lymphotoxin beta receptor multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of LTBR mRNA] CTD PMID:23452621 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539
JBrowse link
G Lyz2 lysozyme 2 multiple interactions
affects expression
ISO
EXP
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LYZ mRNA]
Curcumin affects the expression of LYZ2 mRNA
CTD PMID:18200517 PMID:18539377 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MADCAM1 mRNA] CTD PMID:18200517 NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MAOA mRNA] CTD PMID:18200517 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases lipidation
decreases expression
increases expression
multiple interactions
ISO Curcumin results in increased lipidation of MAP1LC3B protein
Curcumin results in decreased expression of MAP1LC3B protein
Curcumin results in increased expression of MAP1LC3B mRNA
3-methyladenine inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; Curcumin inhibits the reaction [4-phenylbutyric acid results in decreased expression of MAP1LC3B protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MAP1LC3B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of MAP1LC3B protein]; Sirolimus promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; U 0126 inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]
CTD PMID:34634291 PMID:36640941 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K1 results in decreased susceptibility to [Curcumin co-treated with Mitomycin] CTD PMID:21810436 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 results in decreased susceptibility to [Curcumin co-treated with Mitomycin] CTD PMID:21810436 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases expression ISO Curcumin results in increased expression of MAP2K3 mRNA CTD PMID:15713895 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 decreases expression
increases phosphorylation
ISO Curcumin results in decreased expression of MAP2K4 mRNA
Curcumin increases phosphorylation of MAP2K4 protein in uterine cervix
CTD
RGD
PMID:15713895 PMID:25198898 RGD:150429751 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]
Curcumin results in decreased expression of MAP3K1 mRNA
CTD PMID:15713895 PMID:17148446 PMID:23452621 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases phosphorylation ISO Curcumin increases phosphorylation of MAP3K5 protein in uterine cervix RGD PMID:25198898 RGD:150429751 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression
decreases activity
ISO
EXP
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [Curcumin results in decreased activity of MAPK1 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]
Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK1 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]
Curcumin results in decreased expression of MAPK1 protein
CTD PMID:11035063 PMID:11981161 PMID:16934299 PMID:17372590 PMID:17535857 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions EXP Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of MAPK10 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK10 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK10 protein] CTD PMID:24952339 PMID:27535828 PMID:27966075 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases activity ISO Curcumin results in increased activity of MAPK12 protein CTD PMID:21594647 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK14 mRNA]; MAPK14 protein affects the reaction [Curcumin results in increased expression of HMOX1 protein] CTD PMID:17151092 PMID:18357586 PMID:31521693 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression
decreases activity
ISO
EXP
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; [Curcumin results in decreased activity of MAPK3 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK3 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]
Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK3 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]
Curcumin results in decreased expression of MAPK3 protein
CTD PMID:11035063 PMID:11981161 PMID:16934299 PMID:17372590 PMID:17535857 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
decreases phosphorylation
increases expression
ISO
EXP
Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK8 mRNA]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]
Curcumin increases phosphorylation of MAPK8 protein in uterine cervix
Curcumin results in decreased phosphorylation of MAPK8 protein
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK8 protein
Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]
Curcumin results in increased expression of MAPK8 mRNA
Curcumin results in increased phosphorylation of MAPK8 protein
CTD
RGD
PMID:11981161 PMID:16101141 PMID:16678799 PMID:16934299 PMID:17372590 More... RGD:150429751 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO
EXP
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]
Curcumin results in decreased phosphorylation of MAPK9 protein
Curcumin results in increased phosphorylation of MAPK9 protein
Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK9 protein
CTD PMID:11981161 PMID:17372590 PMID:18316600 PMID:18321868 PMID:18332871 More... NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of MAPT mRNA] CTD PMID:31521693 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Curcumin results in decreased expression of MCL1 protein alternative form CTD PMID:18829502 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression EXP Curcumin results in decreased expression of MCM2 mRNA CTD PMID:18299980 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO Curcumin results in decreased expression of MCM7 mRNA CTD PMID:17198877 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression
increases expression
multiple interactions
ISO [Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of MDM2 mRNA; Curcumin results in decreased expression of MDM2 protein
Curcumin analog results in increased expression of MDM2 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein]
CTD PMID:17332326 PMID:24831732 PMID:26409325 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mecp2 methyl CpG binding protein 2 decreases expression ISO Curcumin results in decreased expression of MECP2 protein CTD PMID:23593078 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689
JBrowse link
G Mef2c myocyte enhancer factor 2C decreases expression ISO Curcumin results in decreased expression of MEF2C mRNA CTD PMID:27237783 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Meltf melanotransferrin decreases expression ISO Curcumin results in decreased expression of MELTF mRNA CTD PMID:17198877 NCBI chr11:68,884,446...68,906,300
Ensembl chr11:68,884,446...68,906,300
JBrowse link
G Mettl7a methyltransferase like 7A multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of METTL7A mRNA] CTD PMID:18200517 NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154
JBrowse link
G Mfn1 mitofusin 1 increases expression EXP Curcumin results in increased expression of MFN1 protein CTD PMID:28698153 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase increases expression ISO Curcumin results in increased expression of MFNG mRNA CTD PMID:17198877 NCBI chr 7:110,310,810...110,328,653
Ensembl chr 7:110,310,812...110,328,653
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression
increases expression
decreases activity
multiple interactions
ISO Curcumin results in decreased expression of MGMT mRNA
Curcumin results in increased expression of MGMT mRNA
Curcumin results in decreased activity of MGMT protein
Curcumin results in increased expression of and results in increased activity of MGMT protein
CTD PMID:16950796 PMID:17596214 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression EXP Curcumin results in increased expression of MGST1 mRNA CTD PMID:18299980 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Mir125a microRNA 125a decreases expression
multiple interactions
ISO Curcumin results in decreased expression of MIR125A mRNA
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of MIR125A mRNA]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]
CTD PMID:29723631 PMID:33952798 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710
JBrowse link
G Mir146a microRNA 146a multiple interactions ISO Curcumin inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA] CTD PMID:22099153 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mir19a microRNA 19a multiple interactions ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of MIR19A mRNA] CTD PMID:24831732 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
JBrowse link
G Mir21 microRNA 21 decreases expression ISO Curcumin results in decreased expression of MIR21 mRNA CTD PMID:29723631 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir22 microRNA 22 increases expression ISO Curcumin results in increased expression of MIR22 CTD PMID:26244872 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Mir222 microRNA 222 decreases expression ISO Curcumin results in decreased expression of MIR222 mRNA CTD PMID:29723631 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006
JBrowse link
G Mir223 microRNA 223 increases expression ISO Curcumin results in increased expression of MIR223 mRNA CTD PMID:29723631 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996
JBrowse link
G Mir27a microRNA 27a decreases expression ISO Curcumin results in decreased expression of MIR27A mRNA CTD PMID:29723631 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917
JBrowse link
G Mir27b microRNA 27b decreases expression ISO Curcumin results in decreased expression of MIR27B mRNA CTD PMID:29723631 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529
JBrowse link
G Mir30a microRNA 30a increases expression ISO Curcumin results in increased expression of MIR30A mRNA CTD PMID:29723631 NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670
JBrowse link
G Mir34a microRNA 34a multiple interactions EXP Curcumin inhibits the reaction [Cyclosporine results in increased expression of MIR34A mRNA] CTD PMID:32569592 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
JBrowse link
G Mir532 microRNA 532 increases expression
multiple interactions
ISO Curcumin results in increased expression of MIR532 mRNA
MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; NRIP1 mRNA alternative form inhibits the reaction [Curcumin results in increased expression of MIR532 mRNA]
CTD PMID:37471645 NCBI chr  X:15,247,315...15,247,393
Ensembl chr  X:15,247,315...15,247,393
JBrowse link
G Mir802 microRNA 802 multiple interactions EXP Curcumin inhibits the reaction [Acetaminophen results in increased expression of MIR802 mRNA] CTD PMID:33350580 NCBI chr11:32,626,525...32,626,620
Ensembl chr11:32,626,525...32,626,620
JBrowse link
G Mir99a microRNA 99a multiple interactions ISO Curcumin inhibits the reaction [benzyl isothiocyanate results in increased expression of MIR99A mRNA] CTD PMID:31587482 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression
ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of MKI67 protein
Curcumin results in decreased expression of MKI67 protein
CTD PMID:17440100 PMID:18226269 PMID:19372569 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mme membrane metallo-endopeptidase decreases expression ISO Curcumin results in decreased expression of MME mRNA CTD PMID:17198877 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] CTD PMID:30098273 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO Curcumin results in increased expression of MMP10 mRNA CTD PMID:15713895 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO Curcumin inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA] CTD PMID:20338993 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of MMP14 protein
Curcumin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP14 mRNA]
CTD PMID:16934674 PMID:18200517 PMID:18495463 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
decreases activity
increases activity
ISO
EXP
Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of MMP2 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP2 protein]; Curcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP2 protein]
Curcumin results in decreased activity of MMP2 protein
Curcumin results in increased activity of MMP2 protein
Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP2 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP2 mRNA]
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]
CTD PMID:16934674 PMID:17531121 PMID:17996675 PMID:18200517 PMID:18226269 More... NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO Curcumin results in increased expression of MMP3 mRNA CTD PMID:15713895 PMID:18321735 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO Curcumin inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]; Curcumin inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA] CTD PMID:17928719 PMID:23452621 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
decreases expression
increases activity
affects expression
ISO
EXP
3-caffeoyl-4-dihydrocaffeoylquinic acid promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP9 protein]; Curcumin promotes the reaction [3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; Curcumin promotes the reaction [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; Curcumin promotes the reaction [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]]; Curcumin results in decreased secretion of and results in decreased activity of MMP9 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP9 protein]
Curcumin results in decreased activity of MMP9 protein
Curcumin results in increased activity of MMP9 protein
Curcumin affects the expression of MMP9 mRNA; Curcumin affects the expression of MMP9 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased activity of MMP9 protein]; [Zinc binds to Curcumin] inhibits the reaction [Acetic Acid results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of MMP9 protein; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of and results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP9 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP9 mRNA]
CTD PMID:16219905 PMID:16243823 PMID:17291458 PMID:17440100 PMID:17531121 More... NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mphosph6 M phase phosphoprotein 6 decreases expression ISO Curcumin results in decreased expression of MPHOSPH6 mRNA CTD PMID:18421014 NCBI chr19:45,860,152...45,870,117
Ensembl chr19:45,860,154...45,870,170
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP
ISO
Curcumin inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Curcumin inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of MPO protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of MPO protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of MPO protein]]
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MPO protein]; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MPO protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of MPO protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MPO protein]
Curcumin analog results in decreased activity of MPO protein
Curcumin results in decreased activity of MPO protein
CTD PMID:16804969 PMID:16867261 PMID:17276891 PMID:17351913 PMID:17373747 More... NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mrpl1 mitochondrial ribosomal protein L1 increases expression ISO Curcumin results in increased expression of MRPL1 mRNA CTD PMID:17198877 NCBI chr14:13,300,522...13,359,654
Ensembl chr14:13,300,522...13,359,721
JBrowse link
G Mrpl47 mitochondrial ribosomal protein L47 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MRPL47 mRNA] CTD PMID:18200517 NCBI chr 2:115,507,842...115,520,093
Ensembl chr 2:115,500,264...115,518,994
JBrowse link
G Ms4a1 membrane spanning 4-domains A1 decreases expression
increases expression
ISO Curcumin results in decreased expression of MS4A1 mRNA
Curcumin results in increased expression of MS4A1 mRNA
CTD PMID:17198877 PMID:18421014 NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512
JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression
decreases expression
ISO
EXP
Curcumin affects the expression of MSMO1 mRNA
Curcumin results in decreased expression of MSMO1 mRNA
CTD PMID:27208389 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Msn moesin multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MSN mRNA] CTD PMID:18200517 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of MSR1 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:23386263 NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Mst1r macrophage stimulating 1 receptor multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [RELA protein binds to MST1R promoter]; Curcumin inhibits the reaction [RELA protein results in increased expression of MST1R mRNA]
Curcumin results in decreased expression of MST1R mRNA; Curcumin results in decreased expression of MST1R protein
CTD PMID:18593918 NCBI chr 8:108,596,100...108,611,441
Ensembl chr 8:108,597,299...108,612,455
JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
EXP Curcumin affects the reaction [Mercuric Chloride results in increased expression of MT1A mRNA]
Curcumin results in increased expression of MT1A mRNA
CTD PMID:20229497 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
JBrowse link
G Mt2A metallothionein 2A multiple interactions
increases expression
EXP Curcumin affects the reaction [Mercuric Chloride results in increased expression of MT2A mRNA]
Curcumin results in increased expression of MT2A mRNA
CTD PMID:20229497 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions
decreases expression
ISO Curcumin results in decreased phosphorylation of MTOR protein
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of and results in increased phosphorylation of MTOR protein]; Curcumin promotes the reaction [Sirolimus results in decreased phosphorylation of MTOR protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of MTOR protein
Curcumin analog results in decreased expression of MTOR mRNA; Curcumin results in decreased expression of MTOR mRNA
CTD PMID:20554536 PMID:21450334 PMID:26409325 PMID:27363783 PMID:33582110 More... NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Curcumin inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA] CTD PMID:34167450 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
JBrowse link
G Mvd mevalonate diphosphate decarboxylase decreases expression ISO Curcumin results in decreased expression of MVD mRNA CTD PMID:17198877 NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
JBrowse link
G Mvk mevalonate kinase affects expression
decreases expression
ISO
EXP
Curcumin affects the expression of MVK mRNA
Curcumin results in decreased expression of MVK mRNA
CTD PMID:27208389 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
JBrowse link
G Mxd1 max dimerization protein 1 increases expression ISO Curcumin results in increased expression of MXD1 mRNA CTD PMID:15713895 NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751
JBrowse link
G Mxd3 Max dimerization protein 3 decreases expression ISO Curcumin results in decreased expression of MXD3 mRNA CTD PMID:15713895 PMID:17198877 NCBI chr17:9,301,430...9,305,156
Ensembl chr17:9,301,399...9,305,157
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases expression
ISO [Curcumin co-treated with Doxorubicin] affects the expression of MYC mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MYC protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MYC mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of MYC protein
Curcumin results in increased expression of MYC mRNA
Curcumin analog results in decreased expression of MYC protein; Curcumin results in decreased expression of MYC mRNA; Curcumin results in decreased expression of MYC protein
CTD PMID:15713895 PMID:15911101 PMID:16219905 PMID:16243823 PMID:17041101 More... NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO
EXP
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of MYD88 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein]
CTD PMID:19002562 PMID:23452621 PMID:34719837 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Myh1 myosin heavy chain 1 decreases expression EXP Curcumin results in decreased expression of MYH1 mRNA CTD PMID:18299980 NCBI chr10:51,885,913...51,909,699
Ensembl chr10:51,885,913...51,946,295
JBrowse link
G Myh6 myosin heavy chain 6 decreases expression ISO Curcumin results in decreased expression of MYH6 mRNA CTD PMID:27237783 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions
decreases expression
EXP carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of MYH7 mRNA]; Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]] CTD PMID:25093688 PMID:26612707 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myl12a myosin light chain 12A increases expression ISO Curcumin results in increased expression of MYL12A mRNA CTD PMID:17999991 NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580
JBrowse link
G Myl4 myosin, light chain 4 decreases expression ISO Curcumin results in decreased expression of MYL4 mRNA CTD PMID:27237783 NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363
JBrowse link
G Myl9 myosin light chain 9 multiple interactions ISO Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYL9 protein modified form] CTD PMID:35817260 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
JBrowse link
G Mylk myosin light chain kinase increases expression
multiple interactions
ISO Curcumin results in increased expression of MYLK mRNA
Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYLK mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYLK protein]
CTD PMID:21594647 PMID:35817260 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
JBrowse link
G Myo18a myosin XVIIIa increases expression ISO Curcumin results in increased expression of MYO18A mRNA CTD PMID:18421014 NCBI chr10:62,654,218...62,755,465
Ensembl chr10:62,654,281...62,755,468
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 decreases expression
multiple interactions
ISO Curcumin analog results in decreased expression of NAIP mRNA; Curcumin results in decreased expression of NAIP mRNA
[Curcumin co-treated with Doxorubicin] affects the expression of NAIP mRNA; [Curcumin co-treated with Oxygen deficiency] results in decreased expression of NAIP protein
CTD PMID:15911101 PMID:17671737 PMID:19250217 PMID:23452621 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542
JBrowse link
G Nanog Nanog homeobox multiple interactions
increases expression
ISO 2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of NANOG mRNA]
Curcumin results in increased expression of NANOG mRNA; Curcumin results in increased expression of NANOG protein
CTD PMID:25822711 PMID:27237783 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nanos1 nanos C2HC-type zinc finger 1 decreases expression ISO Curcumin results in decreased expression of NANOS1 mRNA CTD PMID:17999991 NCBI chr 1:259,897,663...259,901,561
Ensembl chr 1:259,897,939...259,898,730
JBrowse link
G Ncam1 neural cell adhesion molecule 1 increases expression EXP Curcumin results in increased expression of NCAM1 protein modified form CTD PMID:19161989 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Curcumin promotes the reaction [VDR protein binds to NCOA1 protein] CTD PMID:20153625 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Nefm neurofilament medium chain increases expression EXP Curcumin results in increased expression of NEFM mRNA CTD PMID:18299980 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Neil1 nei-like DNA glycosylase 1 multiple interactions ISO Curcumin inhibits the reaction [Copper binds to and results in decreased activity of NEIL1 protein]; Curcumin inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein] CTD PMID:20622253 NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258
JBrowse link
G Nes nestin multiple interactions
increases expression
EXP Curcumin inhibits the reaction [bisphenol A results in decreased expression of NES mRNA]
Curcumin results in increased expression of NES mRNA
CTD PMID:25963729 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Neurod1 neuronal differentiation 1 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROD1 mRNA]
Curcumin results in increased expression of NEUROD1 mRNA
CTD PMID:25963729 NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649
JBrowse link
G Neurog1 neurogenin 1 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROG1 mRNA]
Curcumin results in increased expression of NEUROG1 mRNA
CTD PMID:25963729 NCBI chr17:8,362,878...8,364,397
Ensembl chr17:8,362,821...8,364,571
JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 increases expression ISO Curcumin results in increased expression of NFE2L1 protein CTD PMID:23710286 NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
increases activity
decreases response to substance
decreases methylation
affects localization
increases localization
ISO
EXP
[Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [quinocetone results in increased expression of NFE2L2 mRNA]; Curcumin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Curcumin analog results in decreased susceptibility to Acrolein]; NFE2L2 protein affects the reaction [Curcumin results in decreased susceptibility to Acrolein]
Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein
Curcumin analog results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 protein modified form
Curcumin results in increased activity of NFE2L2 protein
NFE2L2 gene mutant form results in decreased susceptibility to Curcumin
Curcumin analog results in decreased methylation of NFE2L2 promoter
Curcumin affects the localization of NFE2L2 protein; Curcumin analog affects the localization of NFE2L2 protein
Curcumin results in increased localization of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; [Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [decamethrin results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein modified form]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [maleic acid affects the expression of NFE2L2 protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Streptozocin affects the localization of NFE2L2 protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Curcumin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Curcumin results in increased activity of RELA protein]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]]; pyrazolanthrone inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]
Curcumin analog results in increased expression of NFE2L2 mRNA; Curcumin analog results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein
[Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; [Curcumin co-treated with Benzo(a)pyrene] affects the localization of NFE2L2 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NFE2L2 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form affects the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL1B mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL6 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of TNF mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]
CTD PMID:17449203 PMID:17535857 PMID:17640564 PMID:18006204 PMID:18321868 More... NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity
decreases expression
decreases localization
ISO
EXP
Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased activity of NFKB1 protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Curcumin results in decreased activity of [NFKB1 protein binds to RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]
Curcumin analog results in decreased activity of NFKB1 protein; Curcumin results in decreased activity of NFKB1 protein
[Zinc binds to Curcumin] which affects the expression of NFKB1 mRNA; Curcumin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]]
Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [NFKB1 protein binds to RELA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of NFKB1 mRNA]
Curcumin results in decreased expression of NFKB1 protein
Curcumin results in decreased localization of NFKB1 protein
CTD PMID:15489888 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 More... NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 decreases activity ISO Curcumin results in decreased activity of NFKB2 protein CTD PMID:16173963 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
increases expression
decreases expression
ISO
EXP
Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of NFKBIA protein modified form]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [NFKBIA protein results in increased degradation of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Paclitaxel results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Sodium Fluoride results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]; NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin inhibits the reaction [Fluorouracil results in decreased expression of NFKBIA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein]
Curcumin results in decreased phosphorylation of NFKBIA protein
Curcumin results in increased expression of NFKBIA protein
CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Fructose results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Curcumin results in decreased expression of NFKBIA protein
CTD PMID:12216086 PMID:15489888 PMID:15793857 PMID:16023083 PMID:16219905 More... NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions EXP Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein] CTD PMID:16934299 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nfya nuclear transcription factor Y subunit alpha decreases expression ISO Curcumin results in decreased expression of NFYA mRNA CTD PMID:15713895 NCBI chr 9:12,587,437...12,613,911
Ensembl chr 9:12,586,259...12,613,898
JBrowse link
G Ngfr nerve growth factor receptor decreases expression ISO Curcumin results in decreased expression of NGFR mRNA CTD PMID:33539684 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nhlrc2 NHL repeat containing 2 decreases expression ISO Curcumin results in decreased expression of NHLRC2 mRNA CTD PMID:17999991 NCBI chr 1:255,589,743...255,648,904
Ensembl chr 1:255,589,742...255,651,408
JBrowse link
G Nkx2-5 NK2 homeobox 5 decreases expression ISO Curcumin results in decreased expression of NKX2-5 mRNA CTD PMID:27237783 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO Curcumin results in decreased expression of NKX3-1 mRNA; Curcumin results in decreased expression of NKX3-1 protein CTD PMID:17303007 PMID:18719366 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA] CTD PMID:23452621 NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 protein] CTD PMID:34998855 PMID:35063475 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression ISO Curcumin results in increased expression of NME1 mRNA CTD PMID:17198877 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
JBrowse link
G Nmt2 N-myristoyltransferase 2 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NMT2 mRNA] CTD PMID:18200517 NCBI chr17:74,917,833...74,964,788
Ensembl chr17:74,917,833...74,961,080
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA] CTD PMID:23452621 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 multiple interactions ISO Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [NOD2 protein binds to NOD2 protein]]; Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]] CTD PMID:18413660 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP
ISO
Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of NOS1 mRNA]
Curcumin inhibits the reaction [Cadmium Chloride results in decreased expression of NOS1 protein]
CTD PMID:17627722 PMID:24662163 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases activity
affects expression
affects activity
ISO
EXP
Curcumin inhibits the reaction [Paraquat results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [quinocetone results in increased activity of NOS2 protein]; Curcumin inhibits the reaction [quinocetone results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]
Curcumin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]]
Curcumin results in decreased activity of NOS2 protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Dinitrochlorobenzene results in decreased expression of NOS2 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Sodium Selenite results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Sodium Selenite results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]]
Curcumin affects the expression of NOS2 mRNA
Curcumin affects the activity of NOS2 protein
CTD PMID:7530002 PMID:12628514 PMID:16934299 PMID:17373747 PMID:17434272 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein] CTD PMID:18660423 PMID:23452621 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Notch1 notch receptor 1 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of NOTCH1 mRNA; Curcumin results in decreased expression of NOTCH1 protein
[Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 protein
CTD PMID:17927689 PMID:18640131 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Curcumin inhibits the reaction [Cyclosporine results in increased expression of NOX4 protein] CTD PMID:32569592 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of NPC1L1 protein] CTD PMID:37701206 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
JBrowse link
G Npc2 NPC intracellular cholesterol transporter 2 decreases expression ISO Curcumin results in decreased expression of NPC2 mRNA CTD PMID:17198877 NCBI chr 6:104,397,239...104,418,161
Ensembl chr 6:104,378,644...104,418,155
JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression
EXP carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of NPPA mRNA] CTD PMID:26612707 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
increases activity
multiple interactions
EXP
ISO
Curcumin results in increased expression of NQO1 mRNA; Curcumin results in increased expression of NQO1 protein
Curcumin results in increased activity of NQO1 protein
Curcumin analog results in increased expression of NQO1 mRNA; Curcumin analog results in increased expression of NQO1 protein; Curcumin results in increased expression of NQO1 mRNA; Curcumin results in increased expression of NQO1 protein
Curcumin analog inhibits the reaction [Rotenone results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NQO1 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of NQO1 protein]
[Curcumin co-treated with Chloranil] results in increased expression of NQO1 protein; Curcumin affects the expression of and results in increased activity of NQO1 protein; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NQO1 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]
CTD PMID:12628514 PMID:17198877 PMID:17535857 PMID:18299980 PMID:18321868 More... NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression
multiple interactions
ISO Curcumin results in increased expression of NR1H3 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of NR1H3 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of NR1H3 protein]
[Curcumin cotreated with oxidized LDL] increases expression of Nr1h3 protein in macrophages
CTD
RGD
PMID:16713233 PMID:37701206 PMID:25064633 RGD:401850557 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
affects expression
ISO Curcumin results in increased activity of NR1I2 protein
Curcumin affects the expression of NR1I2 mRNA
CTD PMID:17210444 PMID:29933105 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression
multiple interactions
EXP
ISO
Curcumin results in increased expression of NR3C1 mRNA
Curcumin inhibits the reaction [Dexamethasone results in increased phosphorylation of NR3C1 protein]
CTD PMID:17022948 PMID:18483179 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO Curcumin results in decreased expression of NR4A2 mRNA CTD PMID:17999991 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of NRIP1 mRNA alternative form
NRIP1 mRNA alternative form inhibits the reaction [Curcumin results in increased expression of MIR532 mRNA]
CTD PMID:37471645 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Ntn1 netrin 1 multiple interactions EXP Curcumin inhibits the reaction [Cadmium Chloride results in increased export of NTN1 protein] CTD PMID:29421648 NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NTRK2 protein] CTD PMID:29723552 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Nup98 nucleoporin 98 and 96 precursor increases expression ISO Curcumin results in increased expression of NUP98 mRNA CTD PMID:17198877 NCBI chr 1:156,494,423...156,591,415
Ensembl chr 1:156,494,423...156,591,415
JBrowse link
G Oat ornithine aminotransferase affects expression EXP Curcumin affects the expression of OAT mRNA CTD PMID:18539377 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Ocln occludin multiple interactions ISO Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN protein] CTD PMID:35817260 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of ODC1 mRNA
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
CTD PMID:12628514 PMID:17198877 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 mRNA]; Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 protein] CTD PMID:21332098 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OLR1 mRNA] CTD PMID:23386263 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Curcumin inhibits the reaction [Cisplatin results in decreased expression of OPA1 protein] CTD PMID:28698153 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Osmr oncostatin M receptor multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OSMR mRNA] CTD PMID:18200517 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
JBrowse link
G Otud7b OTU deubiquitinase 7B decreases expression ISO Curcumin results in decreased expression of OTUD7B mRNA CTD PMID:18421014 NCBI chr 2:183,661,955...183,722,584
Ensembl chr 2:183,662,163...183,718,674
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO Curcumin results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 decreases cleavage ISO Curcumin results in decreased cleavage of PAK2 protein CTD PMID:15095415 NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases degradation
increases cleavage
decreases expression
decreases cleavage
increases expression
ISO
EXP
[Curcumin co-treated with Bortezomib] results in increased cleavage of PARP1 protein; [Curcumin co-treated with Thalidomide] results in increased cleavage of PARP1 protein; arsenic trioxide promotes the reaction [Curcumin results in increased expression of PARP1 protein modified form]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of PARP1 protein]; Curcumin inhibits the reaction [docetaxel results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; Curcumin promotes the reaction [arsenic trioxide results in increased expression of PARP1 protein modified form]; Curcumin promotes the reaction [arsenite results in increased expression of PARP1 protein]; Curcumin results in increased cleavage of and results in increased activity of PARP1 protein
Curcumin results in increased degradation of PARP1
Curcumin results in increased cleavage of PARP1 protein
[Doxorubicin co-treated with Curcumin] results in increased cleavage of PARP1 protein; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]
Curcumin analog results in decreased expression of PARP1 mRNA
CTD PMID:11035063 PMID:14555224 PMID:14724571 PMID:15569404 PMID:16023083 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pax6 paired box 6 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [bisphenol A results in decreased expression of PAX6 mRNA]
Curcumin results in increased expression of PAX6 mRNA
CTD PMID:25963729 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression
affects expression
ISO Curcumin results in decreased expression of PCK1 mRNA
Curcumin affects the expression of PCK1 mRNA
CTD PMID:17198877 PMID:27208389 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions
increases expression
ISO
EXP
Curcumin results in decreased expression of PCNA protein
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of PCNA protein
[Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of PCNA protein; Curcumin inhibits the reaction [bisphenol A results in increased expression of PCNA protein]
Curcumin results in increased expression of PCNA mRNA
CTD PMID:16101141 PMID:18226269 PMID:23222814 PMID:24831732 PMID:26612707 More... NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 affects expression ISO Curcumin affects the expression of PCSK9 mRNA CTD PMID:27208389 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:18006644 PMID:18784349 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta increases expression
decreases phosphorylation
multiple interactions
decreases expression
ISO
EXP
Curcumin results in increased expression of PDGFRB mRNA
Curcumin results in decreased phosphorylation of PDGFRB protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]
Curcumin results in decreased expression of PDGFRB mRNA; Curcumin results in decreased expression of PDGFRB protein
CTD PMID:17372590 PMID:18006644 PMID:18332871 PMID:21594647 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression ISO Curcumin results in increased expression of PDIA3 mRNA CTD PMID:29723631 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PDK1 protein]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein] CTD PMID:17171638 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases phosphorylation ISO Curcumin results in decreased phosphorylation of PDPK1 protein CTD PMID:34634291 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pdpn podoplanin multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PDPN mRNA] CTD PMID:18200517 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 affects expression
multiple interactions
increases expression
decreases expression
ISO
EXP
Curcumin affects the expression of PECAM1 protein
Curcumin inhibits the reaction [Particulate Matter results in increased expression of PECAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of PECAM1 protein]
Curcumin results in increased expression of PECAM1 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 protein]
Gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein]
CTD PMID:17440100 PMID:17960570 PMID:23845850 PMID:29244817 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Per2 period circadian regulator 2 increases expression ISO Curcumin results in increased expression of PER2 mRNA CTD PMID:17198877 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 decreases expression ISO Curcumin results in decreased expression of PFKFB4 mRNA CTD PMID:17198877 NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression EXP Curcumin results in increased expression of PGD mRNA CTD PMID:18299980 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Pgf placental growth factor multiple interactions EXP Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PGF mRNA] CTD PMID:23845850 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
JBrowse link
G Pgs1 phosphatidylglycerophosphate synthase 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PGS1 mRNA] CTD PMID:18200517 NCBI chr10:103,214,635...103,250,254
Ensembl chr10:103,214,646...103,250,254
JBrowse link
G Phb1 prohibitin 1 decreases expression ISO Curcumin results in decreased expression of PHB1 protein CTD PMID:19137819 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase decreases expression EXP Curcumin results in decreased expression of PHYH mRNA CTD PMID:18539377 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha decreases expression ISO Curcumin analog results in decreased expression of PIK3C2A mRNA CTD PMID:26409325 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO Curcumin analog results in decreased expression of PIK3CA mRNA CTD PMID:26409325 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP Curcumin inhibits the reaction [Cisplatin results in increased expression of PINK1 protein] CTD PMID:28698153 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Pir pirin increases expression EXP Curcumin results in increased expression of PIR mRNA CTD PMID:18299980 NCBI chr  X:30,108,536...30,219,269
Ensembl chr  X:30,108,538...30,219,218
JBrowse link
G Pirb paired Ig-like receptor B multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LILRB3 mRNA] CTD PMID:18200517 NCBI chr 1:65,499,195...65,506,666
Ensembl chr 1:65,499,195...65,506,666
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of PKM protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of PKM protein] CTD PMID:36640941 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLA2G2A mRNA] CTD PMID:18200517 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Plau plasminogen activator, urokinase decreases secretion
multiple interactions
increases expression
decreases expression
ISO Curcumin results in decreased secretion of PLAU protein
Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU protein]
Curcumin results in increased expression of PLAU mRNA
TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PLAU protein]
CTD PMID:18025290 PMID:18226269 PMID:18495463 PMID:35716765 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression
multiple interactions
ISO Curcumin results in increased expression of PLAUR mRNA
Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR protein]
CTD PMID:15713895 PMID:35716765 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP curcumin inhibits the reaction [azoxymethane increases activity of Plcg1 protein in colonic mucosa] RGD PMID:7812955 RGD:151356942 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Plekhh2 pleckstrin homology, MyTH4 and FERM domain containing H2 increases expression ISO Curcumin results in increased expression of PLEKHH2 mRNA CTD PMID:18421014 NCBI chr 6:10,032,837...10,132,081
Ensembl chr 6:10,032,660...10,140,794
JBrowse link
G Plk1 polo-like kinase 1 decreases expression ISO Curcumin analog results in decreased expression of PLK1 mRNA CTD PMID:26409325 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Curcumin analog results in increased expression of PLK2 mRNA CTD PMID:26409325 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Curcumin analog results in increased expression of PLK3 mRNA CTD PMID:26409325 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
G Plk4 polo-like kinase 4 increases expression ISO Curcumin analog results in increased expression of PLK4 mRNA CTD PMID:26409325 NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLOD2 mRNA] CTD PMID:18200517 NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Curcumin results in increased expression of PMAIP1 mRNA CTD PMID:17332930 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression ISO Curcumin results in decreased expression of PMEPA1 mRNA CTD PMID:18719366 NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit decreases expression EXP Curcumin results in decreased expression of POLA2 mRNA CTD PMID:18299980 NCBI chr 1:203,227,183...203,251,350
Ensembl chr 1:203,203,388...203,251,348
JBrowse link
G Polb DNA polymerase beta multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Arsenic results in decreased expression of POLB mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of POLB protein]
Curcumin results in decreased expression of POLB protein
CTD PMID:19401701 PMID:21332098 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit decreases expression EXP Curcumin results in decreased expression of POLE mRNA CTD PMID:18299980 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
JBrowse link
G Porcn porcupine O-acyltransferase multiple interactions
increases expression
EXP Curcumin inhibits the reaction [bisphenol A results in decreased expression of PORCN mRNA]
Curcumin results in increased expression of PORCN mRNA
CTD PMID:25963729 NCBI chr  X:14,285,864...14,298,481
Ensembl chr  X:14,285,871...14,298,481
JBrowse link
G Postn periostin increases expression ISO Curcumin results in increased expression of POSTN mRNA CTD PMID:21594647 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions
decreases expression
increases expression
ISO 2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of POU5F1 mRNA]
Curcumin results in decreased expression of POU5F1 mRNA; Curcumin results in decreased expression of POU5F1 protein
WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 protein]
Curcumin results in increased expression of POU5F1 mRNA; Curcumin results in increased expression of POU5F1 protein
CTD PMID:25822711 PMID:27237783 PMID:33539684 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases expression ISO Curcumin results in decreased expression of PPARD mRNA; Curcumin results in decreased expression of PPARD protein CTD PMID:19294764 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding
decreases expression
increases expression
increases activity
affects localization
multiple interactions
ISO
EXP
Curcumin binds to PPARG protein
Curcumin results in decreased expression of PPARG mRNA
Curcumin results in increased expression of PPARG mRNA; Curcumin results in increased expression of PPARG protein
Curcumin results in increased activity of PPARG protein
Curcumin results in decreased expression of PPARG protein
Curcumin affects the localization of PPARG protein
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Curcumin results in decreased expression of and results in decreased activity of PPARG protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased activity of PPARG protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of PPARG protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG protein]; Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased activity of PPARG protein]; Curcumin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein]
PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin results in decreased expression of PPARG protein modified form
CTD PMID:15486348 PMID:15713005 PMID:16782535 PMID:16959952 PMID:17372590 More... NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
EXP Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein]; Curcumin inhibits the reaction [Potassium Dichromate results in decreased expression of PPARGC1A protein]
Curcumin results in increased expression of PPARGC1A protein
CTD PMID:28951138 PMID:32980475 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppdpf pancreatic progenitor cell differentiation and proliferation factor increases expression ISO Curcumin results in increased expression of PPDPF mRNA CTD PMID:17198877 NCBI chr 3:168,299,309...168,301,040
Ensembl chr 3:168,299,791...168,301,036
JBrowse link
G Ppif peptidylprolyl isomerase F increases expression ISO Curcumin results in increased expression of PPIF mRNA CTD PMID:17198877 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of PPP1CA protein] CTD PMID:27966075 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of PPP1R1B protein] CTD PMID:27966075 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions ISO Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP2CA mRNA] CTD PMID:31521693 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma decreases expression ISO Curcumin results in decreased expression of PPP3CC mRNA CTD PMID:17198877 NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit multiple interactions ISO Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP5C mRNA] CTD PMID:31521693 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
JBrowse link
G Prdx5 peroxiredoxin 5 multiple interactions ISO Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of PRDX5 protein] CTD PMID:36924976 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO Curcumin results in increased phosphorylation of PRKAA1 protein CTD PMID:18790744 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases expression
ISO [PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; PRKCA protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]
Curcumin analog results in decreased expression of PRKCA mRNA
CTD PMID:17178710 PMID:18357586 PMID:26409325 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
affects binding
increases phosphorylation
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; PRKCD protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Staurosporine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Wortmannin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
Curcumin results in increased phosphorylation of and results in increased degradation of PRKCD protein
Curcumin binds to PRKCD protein
CTD PMID:17148446 PMID:17171638 PMID:18357586 PMID:19161989 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions
decreases expression
decreases response to substance
ISO Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]
Curcumin analog results in decreased expression of PRKCE mRNA
PRKCE protein results in decreased susceptibility to Curcumin
CTD PMID:14742295 PMID:17148446 PMID:26409325 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkch protein kinase C, eta multiple interactions ISO Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA] CTD PMID:17148446 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
JBrowse link
G Prkcq protein kinase C, theta multiple interactions EXP Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein] CTD PMID:26713546 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Arsenic results in decreased expression of PRKDC mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PRKDC protein]
Curcumin results in decreased expression of PRKDC mRNA
CTD PMID:17596214 PMID:21332098 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Curcumin inhibits the reaction [Cisplatin results in increased expression of PRKN protein] CTD PMID:28698153 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Prlr prolactin receptor increases expression ISO Curcumin results in increased expression of PRLR mRNA CTD PMID:18421014 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
JBrowse link
G Prom1 prominin 1 multiple interactions
decreases expression
ISO WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 protein]
Curcumin results in decreased expression of PROM1 mRNA; Curcumin results in decreased expression of PROM1 protein
CTD PMID:33539684 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Ptch1 patched 1 multiple interactions EXP [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA] CTD PMID:31612257 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of PTEN protein] CTD PMID:24831732 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein] CTD PMID:27645308 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptges2 prostaglandin E synthase 2 multiple interactions ISO Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGES2 protein] CTD PMID:18321868 NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Curcumin results in decreased expression of PTGS1 mRNA CTD PMID:20816778 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
increases expression
multiple interactions
affects expression
ISO
EXP
Curcumin analog results in decreased expression of PTGS2 mRNA; Curcumin results in decreased expression of PTGS2 mRNA; Curcumin results in decreased expression of PTGS2 protein
Curcumin analog results in increased expression of PTGS2 mRNA
[Curcumin co-treated with Gemcitabine] results in decreased expression of PTGS2 protein; Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]]
Curcumin results in increased expression of PTGS2 mRNA
[Curcumin co-treated with Azoxymethane] results in increased expression of PTGS2 mRNA; [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Quartz results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of PTGS2 protein]
Curcumin affects the expression of PTGS2 mRNA
[Fluorouracil co-treated with Curcumin] results in decreased expression of PTGS2 protein; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased activity of PTGS2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of PTGS2 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of PTGS2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PTGS2 protein]
CTD PMID:15129424 PMID:15489888 PMID:15841493 PMID:15911101 PMID:16023083 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions ISO Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein] CTD PMID:15129424 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 decreases expression ISO Curcumin results in decreased expression of PTPN13 mRNA CTD PMID:15713895 NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 increases expression ISO Curcumin results in increased expression of PTPN6 mRNA CTD PMID:17198877 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Ptpn7 protein tyrosine phosphatase, non-receptor type 7 increases expression ISO Curcumin results in increased expression of PTPN7 mRNA CTD PMID:17198877 NCBI chr13:46,570,904...46,584,048
Ensembl chr13:46,571,712...46,583,308
JBrowse link
G Ptpro protein tyrosine phosphatase, receptor type, O multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTPRO mRNA] CTD PMID:18200517 NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771
JBrowse link
G Ptprr protein tyrosine phosphatase, receptor type, R decreases expression ISO Curcumin results in decreased expression of PTPRR mRNA CTD PMID:21594647 NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603
JBrowse link
G Ptx3 pentraxin 3 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTX3 mRNA] CTD PMID:18200517 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of PYCARD mRNA] CTD PMID:35063475 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rab8a RAB8A, member RAS oncogene family decreases expression ISO Curcumin results in decreased expression of RAB8A mRNA CTD PMID:21594647 NCBI chr16:17,654,027...17,675,385
Ensembl chr16:17,654,034...17,675,678
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP Curcumin inhibits the reaction [Doxorubicin results in increased expression of RAC1 mRNA] CTD PMID:34047412 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; RAD51 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]; U 0126 promotes the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] CTD PMID:21810436 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases activity
multiple interactions
ISO Curcumin results in increased activity of RAF1 protein
piperlongumine inhibits the reaction [Curcumin results in increased activity of RAF1 protein]
CTD PMID:19501152 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ramp1 receptor activity modifying protein 1 decreases expression ISO Curcumin results in decreased expression of RAMP1 mRNA CTD PMID:17198877 NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO Curcumin inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA] CTD PMID:8940178 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rassf2 Ras association domain family member 2 increases expression ISO Curcumin results in increased expression of RASSF2 mRNA CTD PMID:17198877 NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
ISO Curcumin results in decreased phosphorylation of RB1 protein
Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of RB1 protein]
CTD PMID:15738001 PMID:18156803 PMID:23222814 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression ISO Curcumin results in increased expression of RBM39 mRNA CTD PMID:17999991 NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
JBrowse link
G Rbp1 retinol binding protein 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RBP1 mRNA] CTD PMID:18200517 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743
JBrowse link
G Reg3b regenerating family member 3 beta multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3A mRNA] CTD PMID:18200517 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
JBrowse link
G Reg3g regenerating family member 3 gamma multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3G mRNA] CTD PMID:18200517 NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of REL mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]; Curcumin promotes the reaction [Hydrogen Peroxide results in increased expression of REL protein]
Curcumin results in increased expression of REL protein
CTD PMID:23452621 PMID:31521693 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
increases activity
affects activity
increases expression
decreases localization
decreases activity
ISO
EXP
[Curcumin co-treated with Isoflavones] results in decreased activity of RELA protein; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [Acids results in increased activity of RELA protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of RELA protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of RELA protein modified form]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of RELA]; Curcumin inhibits the reaction [Formaldehyde results in increased expression of RELA protein]; Curcumin inhibits the reaction [Glucose results in increased activity of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of and results in increased localization of RELA protein]; Curcumin inhibits the reaction [lauric acid results in increased activity of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]; Curcumin inhibits the reaction [NFKBIA protein results in increased degradation of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased activity of RELA protein]; Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [RELA protein binds to MST1R promoter]; Curcumin inhibits the reaction [RELA protein results in increased expression of MST1R mRNA]; Curcumin inhibits the reaction [Sodium Fluoride results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin results in decreased activity of [NFKB1 protein binds to RELA protein]; Curcumin results in decreased expression of and results in decreased activity of RELA protein; Curcumin results in decreased phosphorylation of and affects the localization of RELA protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased activity of RELA protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]]
[Curcumin co-treated with Gemcitabine] results in decreased expression of RELA protein; Curcumin analog inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of RELA protein]; Curcumin inhibits the reaction [Chloranil affects the localization of RELA protein modified form]; Curcumin inhibits the reaction [Chloranil results in increased expression of RELA protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [NFKB1 protein binds to RELA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
Curcumin results in decreased expression of RELA protein
Curcumin results in increased activity of RELA protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of and results in decreased phosphorylation of RELA protein; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of RELA protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of RELA protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Curcumin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]]; Curcumin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [Streptozocin affects the localization of RELA protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of RELA protein]; Curcumin results in increased expression of and results in increased activity of RELA protein; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; NFE2L2 protein promotes the reaction [Curcumin results in increased activity of RELA protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of RELA protein]]
Curcumin affects the activity of RELA protein
Curcumin results in increased expression of RELA
Curcumin results in decreased localization of RELA protein
Curcumin results in decreased expression of RELA; Curcumin results in decreased expression of RELA mRNA; Curcumin results in decreased expression of RELA protein
CTD PMID:12216086 PMID:12388107 PMID:15489888 PMID:15911101 PMID:16023083 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RELB mRNA] CTD PMID:23452621 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507
JBrowse link
G Reln reelin multiple interactions
increases expression
EXP Curcumin inhibits the reaction [bisphenol A results in decreased expression of RELN mRNA]
Curcumin results in increased expression of RELN mRNA
CTD PMID:25963729 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Retnlb resistin like beta multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RETNLB mRNA] CTD PMID:18200517 NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368
JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit increases expression ISO Curcumin results in increased expression of REV3L protein CTD PMID:19137819 NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099
JBrowse link
G Rfxap regulatory factor X-associated protein decreases expression ISO Curcumin results in decreased expression of RFXAP mRNA CTD PMID:17999991 NCBI chr 2:139,008,052...139,012,235
Ensembl chr 2:139,008,055...139,012,259
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Curcumin results in increased expression of RGS16 mRNA CTD PMID:17198877 NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Curcumin results in decreased expression of RGS4 mRNA CTD PMID:21594647 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rgs7 regulator of G-protein signaling 7 decreases expression ISO Curcumin results in decreased expression of RGS7 mRNA CTD PMID:17999991 NCBI chr13:86,979,269...87,408,834
Ensembl chr13:86,979,279...87,408,888
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Curcumin analog results in decreased expression of RHOA mRNA CTD PMID:26409325 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhob ras homolog family member B decreases expression ISO Curcumin analog results in decreased expression of RHOB mRNA CTD PMID:26409325 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 decreases expression ISO Curcumin results in decreased expression of RIMS2 mRNA CTD PMID:17999991 NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA] CTD PMID:23452621 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Rpl31 ribosomal protein L31 increases expression ISO Curcumin results in increased expression of RPL31 mRNA CTD PMID:17999991 NCBI chr 9:41,647,397...41,651,441
Ensembl chr 9:41,647,426...41,662,129
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation
ISO calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of RPS6 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased expression of RPS6 protein]; Curcumin results in decreased phosphorylation of and results in decreased expression of RPS6 protein CTD PMID:18790744 PMID:21450334 PMID:23222814 PMID:34634291 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
ISO Curcumin results in decreased phosphorylation of RPS6KB1 protein
Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of RPS6KB1 protein]
Curcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of RPS6KB1 protein]
CTD PMID:18790744 PMID:20554536 PMID:27363783 PMID:34634291 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rreb1 ras responsive element binding protein 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA] CTD PMID:18200517 NCBI chr17:26,876,687...27,002,554
Ensembl chr17:26,876,697...27,002,615
JBrowse link
G Rtkn rhotekin multiple interactions ISO Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Butyrates]; Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Fluorouracil]; Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Paclitaxel] CTD PMID:15480428 NCBI chr 4:115,640,813...115,657,952
Ensembl chr 4:115,640,774...115,657,952
JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression ISO Curcumin results in decreased expression of RUNX2 protein CTD PMID:15129424 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Curcumin promotes the reaction [VDR protein binds to RXRA protein] CTD PMID:20153625 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A8 mRNA] CTD PMID:18200517 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A9 mRNA] CTD PMID:18200517 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G S100g S100 calcium binding protein G affects expression EXP Curcumin affects the expression of S100G mRNA CTD PMID:18539377 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433
JBrowse link
G Scarb1 scavenger receptor class B, member 1 affects expression ISO Curcumin affects the expression of SCARB1 mRNA CTD PMID:27208389 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression
affects expression
ISO
EXP
Curcumin results in decreased expression of SCD mRNA
Curcumin affects the expression of SCD1 mRNA; Curcumin affects the expression of SCD1 protein
CTD PMID:20816778 PMID:27208389 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 decreases expression EXP Curcumin results in decreased expression of SCD2 mRNA CTD PMID:27208389 NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232
JBrowse link
G Scrn2 secernin 2 decreases expression ISO Curcumin results in decreased expression of SCRN2 mRNA CTD PMID:17198877 NCBI chr10:82,016,604...82,020,676
Ensembl chr10:82,016,649...82,020,675
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A decreases expression ISO Curcumin results in decreased expression of SDHA mRNA CTD PMID:17198877 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Sele selectin E multiple interactions
affects expression
EXP
ISO
Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELE protein]
Curcumin inhibits the reaction [Particulate Matter results in increased expression of SELE protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of SELE protein]
Curcumin affects the expression of SELE protein
CTD PMID:17960570 PMID:18565277 PMID:29244817 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Sell selectin L multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA] CTD PMID:23452621 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Selp selectin P multiple interactions EXP
ISO
Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELP protein]
Curcumin inhibits the reaction [Particulate Matter results in increased expression of SELP protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of SELP protein]
CTD PMID:18565277 PMID:29244817 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Septin7 septin 7 increases expression ISO Curcumin results in increased expression of SEPTIN7 mRNA CTD PMID:16101141 NCBI chr 8:23,719,448...23,783,247
Ensembl chr 8:23,716,030...23,783,243
JBrowse link
G Serpinb2 serpin family B member 2 increases expression ISO Curcumin results in increased expression of SERPINB2 mRNA CTD PMID:15713895 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
JBrowse link
G Serpinb5 serpin family B member 5 increases expression
multiple interactions
ISO [Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of SERPINB5 mRNA; Curcumin results in increased expression of SERPINB5 protein
[Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein
CTD PMID:17290611 PMID:19944674 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
JBrowse link
G Serpine1 serpin family E member 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of SERPINE1 mRNA
Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 protein]
CTD PMID:15713895 PMID:35716765 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINE2 mRNA] CTD PMID:18200517 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions EXP Curcumin inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] CTD PMID:24704557 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
JBrowse link
G Sfpq splicing factor proline and glutamine rich increases expression ISO Curcumin results in increased expression of SFPQ mRNA CTD PMID:17198877 NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases expression
multiple interactions
EXP Curcumin results in decreased expression of SFRP2 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of SFRP2 mRNA]
CTD PMID:25963729 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063
JBrowse link
G Sfrp5 secreted frizzled-related protein 5 decreases expression ISO Curcumin results in decreased expression of SFRP5 mRNA CTD PMID:16101141 NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224
JBrowse link
G Sfxn1 sideroflexin 1 decreases expression ISO Curcumin results in decreased expression of SFXN1 mRNA CTD PMID:18421014 NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions EXP [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SHH mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of SHH mRNA] CTD PMID:31612257 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Sim2 SIM bHLH transcription factor 2 multiple interactions EXP Curcumin inhibits the reaction [Glucose results in increased expression of SIM2 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of SIM2 protein] CTD PMID:23333261 NCBI chr11:33,414,218...33,453,663
Ensembl chr11:33,414,218...33,453,663
JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of SIRT1 mRNA
Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 protein]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of SIRT1 protein]
CTD PMID:18403477 PMID:32569592 PMID:36037877 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sirt3 sirtuin 3 multiple interactions EXP
ISO
Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 protein]; Curcumin inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein]
Curcumin inhibits the reaction [[GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]]
CTD PMID:26422756 PMID:28698153 PMID:28951138 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
JBrowse link
G Sirt6 sirtuin 6 multiple interactions ISO Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT6 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT6 protein]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]] CTD PMID:33952798 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
JBrowse link
G Sirt7 sirtuin 7 decreases expression ISO Curcumin results in decreased expression of SIRT7 CTD PMID:25644192 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO Curcumin results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression ISO Curcumin results in increased expression of SLC11A2 mRNA CTD PMID:24634837 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression ISO Curcumin results in decreased expression of SLC16A1 protein CTD PMID:21397623 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in decreased expression of SLC18A2 protein] CTD PMID:27966075 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc1a3 solute carrier family 1 member 3 multiple interactions EXP Curcumin inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 mRNA] CTD PMID:23267840 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
JBrowse link
G Slc20a1 solute carrier family 20 member 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC20A1 mRNA] CTD PMID:18200517 NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of SLC2A1 mRNA
ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of SLC2A1 protein]
CTD PMID:21397623 PMID:36640941 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of SLC2A2 mRNA
Curcumin inhibits the reaction [Streptozocin results in decreased expression of SLC2A2 protein]
CTD PMID:21397623 PMID:25541178 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Curcumin results in decreased expression of SLC2A3 mRNA CTD PMID:21397623 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc2a5 solute carrier family 2 member 5 decreases expression ISO Curcumin results in decreased expression of SLC2A5 mRNA CTD PMID:21397623 NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106
JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO Curcumin results in increased expression of SLC30A1 mRNA CTD PMID:17999991 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
JBrowse link
G Slc30a10 solute carrier family 30, member 10 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC30A10 mRNA] CTD PMID:18200517 NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression ISO Curcumin results in decreased expression of SLC37A4 mRNA CTD PMID:16777101 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Curcumin results in increased expression of SLC3A2 mRNA CTD PMID:17198877 PMID:19183254 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Slc48a1 solute carrier family 48 member 1 increases expression ISO Curcumin results in increased expression of SLC48A1 mRNA CTD PMID:17198877 NCBI chr 7:128,915,136...128,923,929
Ensembl chr 7:128,915,195...128,923,024
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC6A3 protein] CTD PMID:30463061 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Curcumin results in increased expression of SLC7A11 mRNA CTD PMID:17999991 PMID:19183254 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO Curcumin results in increased expression of SLCO1A2 mRNA CTD PMID:18421014 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA] CTD PMID:18200517 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein] CTD PMID:26648693 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]] CTD PMID:16959952 PMID:26648693 PMID:32718261 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad4 SMAD family member 4 multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]
Curcumin results in decreased expression of SMAD4 mRNA
CTD PMID:16959952 PMID:27237783 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions EXP [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of SMO mRNA] CTD PMID:31612257 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Smpx small muscle protein, X-linked multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SMPX mRNA] CTD PMID:18200517 NCBI chr  X:37,233,209...37,292,266
Ensembl chr  X:37,234,294...37,276,708
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of SNAI1 protein] CTD PMID:25656647 PMID:34233590 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO Curcumin results in decreased expression of SNAI2 protein CTD PMID:19573523 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Snca synuclein alpha multiple interactions ISO [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:31187328 PMID:31820278 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO Curcumin results in decreased expression of SOCS3 mRNA CTD PMID:18403477 PMID:25822711 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Socs5 suppressor of cytokine signaling 5 decreases expression ISO Curcumin results in decreased expression of SOCS5 protein CTD PMID:21397623 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
EXP
ISO
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; [Curcumin co-treated with Vitamin E] promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased activity of SOD1 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; Curcumin promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]
Curcumin results in increased expression of SOD1 protein
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of SOD1 protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of SOD1 protein]
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of SOD1 mRNA]
CTD PMID:19914224 PMID:25996037 PMID:30934151 PMID:31521693 PMID:35063475 More... NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 affects expression
increases expression
multiple interactions
EXP
ISO
Curcumin affects the expression of SOD2 mRNA; Curcumin affects the expression of SOD2 protein
Curcumin results in increased expression of SOD2 mRNA; Curcumin results in increased expression of SOD2 protein
2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of SOD2 mRNA]
Curcumin analog inhibits the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in decreased expression of and results in decreased activity of SOD2 protein]; Curcumin analog inhibits the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in increased expression of and results in decreased activity of SOD2 protein]; Curcumin analog promotes the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in increased expression of SOD2 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SOD2 protein]
[Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of SOD2 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased activity of SOD2 protein]; Curcumin promotes the reaction [Thyroxine results in increased expression of SOD2 protein]
CTD PMID:11543823 PMID:18299980 PMID:19914224 PMID:22316666 PMID:23452621 More... NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO Curcumin results in increased expression of SOX2 mRNA; Curcumin results in increased expression of SOX2 protein CTD PMID:25822711 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions
increases expression
ISO [Curcumin co-treated with resveratrol] results in increased expression of SOX9 protein
Curcumin results in increased expression of SOX9 protein
CTD PMID:19889203 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO Curcumin results in decreased expression of SP1 protein CTD PMID:18347134 PMID:18593936 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sp3 Sp3 transcription factor decreases expression ISO Curcumin results in decreased expression of SP3 protein CTD PMID:18593936 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
JBrowse link
G Sp4 Sp4 transcription factor decreases expression ISO Curcumin results in decreased expression of SP4 protein CTD PMID:18593936 NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126
JBrowse link
G Sparc secreted protein acidic and cysteine rich multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA] CTD PMID:18200517 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Spib Spi-B transcription factor increases expression ISO Curcumin results in increased expression of SPIB mRNA CTD PMID:17198877 NCBI chr 1:95,018,939...95,024,804
Ensembl chr 1:95,018,947...95,024,780
JBrowse link
G Spock1 sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 increases expression ISO Curcumin results in increased expression of SPOCK1 mRNA CTD PMID:21594647 NCBI chr17:6,741,504...7,221,685
Ensembl chr17:6,742,273...7,224,935
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Curcumin inhibits the reaction [Cadmium Chloride results in increased export of SPP1 protein] CTD PMID:29421648 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sqle squalene epoxidase decreases expression
affects expression
EXP
ISO
Curcumin results in decreased expression of SQLE mRNA
Curcumin affects the expression of SQLE mRNA
CTD PMID:27208389 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Sqstm1 sequestosome 1 decreases expression
increases expression
multiple interactions
ISO Curcumin results in decreased expression of SQSTM1 protein
Curcumin results in increased expression of SQSTM1 protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of SQSTM1 protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of SQSTM1 protein]; Curcumin inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Curcumin inhibits the reaction [Tunicamycin results in decreased expression of SQSTM1 protein]
CTD PMID:34634291 PMID:36640941 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases expression
multiple interactions
decreases activity
ISO Curcumin results in decreased expression of SRC protein
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SRC protein]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased activity of SRC protein
Curcumin analog results in decreased activity of SRC protein; Curcumin results in decreased activity of SRC protein
CTD PMID:16959222 PMID:33617879 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 affects expression
multiple interactions
decreases expression
ISO
EXP
Curcumin affects the expression of SREBF1 mRNA; Curcumin affects the expression of SREBF1 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF1 protein]
Curcumin results in decreased expression of SREBF1 mRNA
CTD PMID:27208389 PMID:37701206 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 affects expression
multiple interactions
decreases expression
ISO
EXP
Curcumin affects the expression of SREBF2 mRNA; Curcumin affects the expression of SREBF2 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF2 protein]
Curcumin results in decreased expression of SREBF2 mRNA
CTD PMID:27208389 PMID:37701206 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Srm spermidine synthase multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SRM mRNA] CTD PMID:18200517 NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 increases expression ISO Curcumin results in increased expression of SRSF1 mRNA CTD PMID:17999991 NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 increases expression ISO Curcumin results in increased expression of SRSF2 mRNA CTD PMID:17198877 NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 increases expression ISO Curcumin results in increased expression of SRSF3 mRNA CTD PMID:17198877 NCBI chr20:7,091,928...7,101,860
Ensembl chr20:7,091,910...7,101,078
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 decreases expression ISO Curcumin results in decreased expression of SRSF5 mRNA CTD PMID:17999991 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 increases expression ISO Curcumin results in increased expression of SRSF6 mRNA CTD PMID:17198877 NCBI chr 3:151,589,546...151,594,869
Ensembl chr 3:151,589,535...151,594,860
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]
CTD PMID:16959222 PMID:21811692 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression
increases phosphorylation
decreases phosphorylation
ISO
EXP
Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of STAT3 protein]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT3 protein]
Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of STAT3 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]
Curcumin results in decreased expression of STAT3 mRNA
Curcumin results in increased phosphorylation of STAT3 protein
Curcumin results in decreased expression of STAT3 mRNA; Curcumin results in decreased expression of STAT3 protein
CTD PMID:16959222 PMID:17666914 PMID:19383353 PMID:20816778 PMID:25822711 More... NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat4 signal transducer and activator of transcription 4 multiple interactions ISO Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein] CTD PMID:17979888 NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases cleavage
decreases expression
ISO Curcumin results in increased cleavage of STAT5A protein
Curcumin results in decreased expression of STAT5A protein
CTD PMID:16959222 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases cleavage
decreases expression
ISO Curcumin results in increased cleavage of STAT5B protein
Curcumin results in decreased expression of STAT5B protein
CTD PMID:16959222 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Sts steroid sulfatase decreases expression ISO Curcumin results in decreased expression of STS mRNA CTD PMID:17198877 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Stx3 syntaxin 3 multiple interactions ISO [Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of STX3 mRNA CTD PMID:22911773 NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
JBrowse link
G Sulf1 sulfatase 1 increases expression ISO Curcumin results in increased expression of SULF1 mRNA; Curcumin results in increased expression of SULF1 protein CTD PMID:21594647 NCBI chr 5:6,362,894...6,526,174
Ensembl chr 5:6,362,911...6,525,584
JBrowse link
G Sulf2 sulfatase 2 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SULF2 mRNA] CTD PMID:18200517 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit decreases expression ISO Curcumin results in decreased expression of SUZ12 mRNA CTD PMID:18421014 NCBI chr10:64,967,035...65,012,916
Ensembl chr10:64,966,967...65,012,738
JBrowse link
G Sycp2 synaptonemal complex protein 2 increases expression ISO Curcumin results in increased expression of SYCP2 mRNA CTD PMID:18421014 NCBI chr 3:165,431,715...165,502,134
Ensembl chr 3:165,436,331...165,498,789
JBrowse link
G Syn2 synapsin II multiple interactions ISO Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SYN2 protein] CTD PMID:32735850 NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 multiple interactions EXP Curcumin inhibits the reaction [sodium arsenite results in increased expression of SYNGAP1 protein] CTD PMID:29723552 NCBI chr20:5,026,366...5,056,659
Ensembl chr20:5,026,364...5,056,672
JBrowse link
G Tada3 transcriptional adaptor 3 affects expression EXP Curcumin affects the expression of TADA3 mRNA CTD PMID:18539377 NCBI chr 4:146,510,213...146,521,975
Ensembl chr 4:146,510,246...146,521,590
JBrowse link
G Taldo1 transaldolase 1 increases expression EXP Curcumin results in increased expression of TALDO1 mRNA CTD PMID:18299980 NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
JBrowse link
G Tbc1d1 TBC1 domain family member 1 decreases expression ISO Curcumin results in decreased expression of TBC1D1 mRNA CTD PMID:17198877 NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499
JBrowse link
G Tbc1d8 TBC1 domain family, member 8 increases expression ISO Curcumin results in increased expression of TBC1D8 mRNA CTD PMID:17999991 NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409
JBrowse link
G Tbk1 TANK-binding kinase 1 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA] CTD PMID:23452621 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
JBrowse link
G Tbxt T-box transcription factor T decreases expression ISO Curcumin results in decreased expression of T mRNA CTD PMID:27237783 NCBI chr 1:52,298,104...52,309,813
Ensembl chr 1:52,298,099...52,305,864
JBrowse link
G Tcf7l2 transcription factor 7 like 2 multiple interactions ISO Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein] CTD PMID:19294764 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967
JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO Curcumin results in decreased activity of TERT protein CTD PMID:17096185 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 increases expression ISO curcumin increases expression of TET2 mRNA and protein in stomach RGD PMID:33058920 RGD:150429654 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534
JBrowse link
G Tf transferrin increases expression ISO Curcumin results in increased expression of TF mRNA CTD PMID:15713895 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP [Curcumin co-treated with Potassium Dichromate] results in increased expression of TFAM protein CTD PMID:32980475 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tfrc transferrin receptor increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of TFRC mRNA
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFRC protein]
CTD PMID:17198877 PMID:18340409 PMID:24634837 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
decreases activity
ISO
EXP
Curcumin inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA]
[1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of TGFB1 mRNA; Curcumin affects the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]
Curcumin results in decreased expression of TGFB1 mRNA; Curcumin results in decreased expression of TGFB1 protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]]; [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA]; [Zinc binds to Curcumin] which affects the expression of TGFB1 mRNA; Curcumin analog inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]]
Curcumin results in decreased activity of TGFB1 protein
CTD PMID:8940178 PMID:16751071 PMID:16959952 PMID:17434272 PMID:18006644 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions
decreases expression
EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]
Curcumin results in decreased expression of TGFBR1 mRNA; Curcumin results in decreased expression of TGFBR1 protein
CTD PMID:16959952 PMID:17531121 PMID:17602960 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions
decreases expression
EXP Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 protein]
Curcumin results in decreased expression of TGFBR2 mRNA; Curcumin results in decreased expression of TGFBR2 protein
CTD PMID:16959952 PMID:17602960 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGM2 mRNA] CTD PMID:18200517 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP
ISO
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein]
Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]
CTD PMID:19631675 PMID:22704994 PMID:27966075 PMID:30463061 PMID:31187328 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THBS1 mRNA] CTD PMID:18200517 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THY1 mRNA] CTD PMID:18200517 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TICAM1 mRNA] CTD PMID:23452621 NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147
JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TICAM2 mRNA] CTD PMID:23452621 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
ISO
EXP
Curcumin inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]
Curcumin inhibits the reaction [Cadmium Chloride results in increased export of TIMP1 protein]
Curcumin results in decreased expression of TIMP1 protein
CTD PMID:17996675 PMID:18200517 PMID:27363783 PMID:29421648 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]
Curcumin results in decreased expression of TIMP2 protein
CTD PMID:16934674 PMID:17996675 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of and affects the localization of TJP1 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 protein] CTD PMID:26191140 PMID:35817260 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr1 toll-like receptor 1 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA] CTD PMID:23452621 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions EXP
ISO
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]
CTD PMID:22683883 PMID:23452621 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
decreases expression
ISO
EXP
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein]
Curcumin results in decreased expression of TLR4 mRNA; Curcumin results in decreased expression of TLR4 protein
CTD PMID:16678799 PMID:17965732 PMID:19002562 PMID:22683883 PMID:34719837 More... NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnc tenascin C multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNC mRNA] CTD PMID:18200517 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
affects expression
increases expression
ISO
EXP
[Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]; Curcumin inhibits the reaction [TNF protein affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; Curcumin inhibits the reaction [TNF protein results in decreased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of TNF mRNA]; Curcumin inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Curcumin inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]
Curcumin results in decreased expression of TNF mRNA; Curcumin results in decreased expression of TNF protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of TNF protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of TNF protein]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TNF protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in increased expression of TNF protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Curcumin inhibits the reaction [Colistin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Fructose results in increased expression of TNF protein]; Curcumin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of TNF protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELP protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]]
Curcumin affects the expression of TNF mRNA; Curcumin affects the expression of TNF protein
Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of TNF mRNA]; Curcumin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of TNF mRNA]
Curcumin results in increased expression of TNF mRNA
CTD PMID:14555224 PMID:15489888 PMID:16023083 PMID:16219905 PMID:16584726 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein] CTD PMID:18226269 PMID:23452621 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A multiple interactions EXP Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNFRSF12A mRNA] CTD PMID:34047412 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein] CTD PMID:17666914 PMID:23452621 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B protein] CTD PMID:17666914 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in increased expression of TNFRSF21 protein CTD PMID:27430728 NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085
JBrowse link
G Tnfrsf22 tumor necrosis factor receptor superfamily, member 22 multiple interactions ISO [Arsenic Trioxide co-treated with Curcumin] results in increased expression of TNFRSF10C protein CTD PMID:27430728 NCBI chr 1:198,840,452...198,860,713
Ensembl chr 1:198,840,453...198,856,309
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFSF10 mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in decreased activity of RELA protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CXCL8 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP9 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PLAU protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PTGS2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of VEGFA protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10B protein]
Curcumin results in decreased expression of TNFSF10 mRNA
CTD PMID:15713895 PMID:16101141 PMID:18226269 PMID:23452621 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein]
Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein]
CTD PMID:15129424 PMID:18719352 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tnfsf12 TNF superfamily member 12 multiple interactions EXP Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNFSF12 protein] CTD PMID:34047412 NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
JBrowse link
G Tnfsf14 TNF superfamily member 14 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFSF14 mRNA] CTD PMID:23452621 NCBI chr 9:2,068,295...2,073,128
Ensembl chr 9:2,069,104...2,073,216
JBrowse link
G Tnks tankyrase decreases expression ISO Curcumin analog results in decreased expression of TNKS mRNA CTD PMID:26409325 NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:29315967 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions
decreases expression
ISO [Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA; [sulfinosine co-treated with Curcumin] results in decreased expression of TOP2A mRNA
Curcumin analog results in decreased expression of TOP2A mRNA; Curcumin results in decreased expression of TOP2A mRNA
CTD PMID:18348204 PMID:18414057 PMID:26409325 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Top2b DNA topoisomerase II beta multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B protein]
Curcumin analog results in decreased expression of TOP2B mRNA
CTD PMID:21332098 PMID:26409325 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085
JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
increases expression
increases phosphorylation
increases acetylation
affects expression
affects localization
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of TP53 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of TP53 protein; [piperine co-treated with Curcumin] results in decreased expression of TP53 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of TP53 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; dorsomorphin inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]; SB 203580 inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]
Curcumin analog results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 protein
Curcumin results in increased expression of TRP53 mRNA
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TRP53 protein]; Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TRP53 protein]
[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of TP53; Curcumin results in increased expression of TP53 protein
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TP53 mRNA]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]; Curcumin results in decreased expression of and results in decreased acetylation of TP53 protein
Curcumin results in increased acetylation of TP53 protein
Curcumin affects the expression of TP53 protein; Curcumin analog affects the expression of TP53 mRNA; Curcumin analog affects the expression of TP53 protein
Curcumin affects the localization of TP53 protein
CTD PMID:17041101 PMID:17332930 PMID:19020741 PMID:19227835 PMID:19944674 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein] CTD PMID:22704994 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link
G Tradd TNFRSF1A-associated via death domain decreases expression ISO Curcumin results in decreased expression of TRADD mRNA CTD PMID:15713895 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]
Curcumin results in decreased expression of TRAF1 protein
CTD PMID:16023083 PMID:16219905 PMID:19372569 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Traf2 Tnf receptor-associated factor 2 increases expression ISO Curcumin results in increased expression of TRAF2 mRNA CTD PMID:16101141 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Traf3 Tnf receptor-associated factor 3 increases expression ISO Curcumin results in increased expression of TRAF3 mRNA CTD PMID:16101141 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
JBrowse link
G Traf6 TNF receptor associated factor 6 increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of TRAF6 mRNA
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TRAF6 mRNA]
CTD PMID:16101141 PMID:34719837 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 increases expression ISO Curcumin results in increased expression of DNMT2 CTD PMID:25644192 NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 decreases expression ISO Curcumin results in decreased expression of TREM1 mRNA CTD PMID:17198877 NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Curcumin results in increased expression of TRIB3 mRNA CTD PMID:18719366 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Trim15 tripartite motif containing 15 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TRIM15 mRNA] CTD PMID:18200517 NCBI chr20:1,700,905...1,710,249
Ensembl chr20:1,700,905...1,710,249
JBrowse link
G Trim16 tripartite motif-containing 16 increases expression ISO Curcumin results in increased expression of TRIM16 mRNA CTD PMID:17999991 NCBI chr10:47,485,982...47,509,010
Ensembl chr10:47,486,297...47,551,907
JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 multiple interactions ISO [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA CTD PMID:20153625 NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017
JBrowse link
G Tsc2 TSC complex subunit 2 decreases phosphorylation ISO Curcumin results in decreased phosphorylation of TSC2 protein CTD PMID:18790744 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions
increases expression
EXP Curcumin inhibits the reaction [bisphenol A results in decreased expression of TUBB3 mRNA]
Curcumin results in increased expression of TUBB3 mRNA
CTD PMID:25963729 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of TXNIP mRNA] CTD PMID:35063475 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
increases oxidation
ISO
EXP
Curcumin analog results in increased expression of TXNRD1 mRNA; Curcumin results in increased expression of TXNRD1 mRNA
Curcumin results in increased oxidation of TXNRD1 protein
CTD PMID:17198877 PMID:18299980 PMID:21782934 PMID:26409325 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Tymp thymidine phosphorylase decreases expression
multiple interactions
ISO Curcumin results in decreased expression of TYMP mRNA; Curcumin results in decreased expression of TYMP protein
[Curcumin results in decreased expression of TYMP protein] which results in increased susceptibility to Cisplatin
CTD PMID:21493726 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TYROBP mRNA] CTD PMID:18200517 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
JBrowse link
G Uba7 ubiquitin-like modifier activating enzyme 7 affects expression
multiple interactions
ISO Curcumin affects the expression of UBA7 mRNA; Curcumin affects the expression of UBA7 protein
Curcumin affects the reaction [Acetylcysteine results in increased expression of UBA7 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of UBA7 protein]
CTD PMID:25649257 NCBI chr 8:108,665,289...108,674,097
Ensembl chr 8:108,665,292...108,674,099
JBrowse link
G Ubc ubiquitin C increases expression ISO Curcumin results in increased expression of UBC mRNA CTD PMID:16101141 NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Curcumin results in decreased expression of UBE2C mRNA CTD PMID:22258452 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Ucp1 uncoupling protein 1 affects expression ISO Curcumin affects the expression of UCP1 mRNA CTD PMID:27208389 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions
increases glucuronidation
ISO
EXP
Curcumin results in increased expression of UGT1A1 mRNA
Curcumin analog results in increased expression of UGT1A1 mRNA; Curcumin analog results in increased expression of UGT1A1 protein
Curcumin promotes the reaction [Aflatoxin B1 results in increased activity of UGT1A1 protein]
UGT1A1 protein results in increased glucuronidation of Curcumin
CTD PMID:14557274 PMID:16819192 PMID:20015472 PMID:26991801 PMID:29228771 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Curcumin results in increased expression of UGT1A6 mRNA CTD PMID:16819192 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Curcumin CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Utp14a UTP14A small subunit processome component increases expression ISO Curcumin results in increased expression of UTP14A mRNA CTD PMID:17198877 NCBI chr  X:127,439,282...127,464,634
Ensembl chr  X:127,439,268...127,464,633
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases expression ISO Curcumin results in increased expression of VASP mRNA CTD PMID:17198877 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 affects expression
multiple interactions
ISO
EXP
Curcumin affects the expression of VCAM1 mRNA
Curcumin inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of VCAM1 protein]
Curcumin analog inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]
Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Curcumin inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]
CTD PMID:18752423 PMID:28700904 PMID:29244817 PMID:30431687 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vcan versican multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VCAN mRNA] CTD PMID:18200517 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO Curcumin promotes the reaction [VDAC1 protein binds to VDAC1 protein] CTD PMID:28343033 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; Curcumin binds to and results in increased activity of VDR protein; Curcumin inhibits the reaction [1,25-dihydroxy-26,27-dimethylcholecalciferol binds to VDR protein]; Curcumin promotes the reaction [VDR protein binds to NCOA1 protein]; Curcumin promotes the reaction [VDR protein binds to RXRA protein] CTD PMID:20153625 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A affects expression
decreases expression
multiple interactions
ISO
EXP
Curcumin affects the expression of VEGFA mRNA
Curcumin results in decreased expression of VEGFA mRNA; Curcumin results in decreased expression of VEGFA protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
[Curcumin co-treated with Gemcitabine] results in decreased expression of VEGFA protein; Curcumin inhibits the reaction [Dietary Fats results in increased expression of VEGFA mRNA]
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; [Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin co-treated with Bortezomib] results in decreased expression of VEGFA protein; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of VEGFA protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; Curcumin results in decreased expression of and results in decreased secretion of VEGFA protein; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of VEGFA protein]
CTD PMID:16219905 PMID:16243823 PMID:16368150 PMID:17440100 PMID:17662242 More... NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor multiple interactions ISO VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein] CTD PMID:18682687 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
G Vim vimentin multiple interactions ISO Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]
CTD PMID:25656647 PMID:26191140 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO
EXP
Curcumin inhibits the reaction [VIP protein results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]
Curcumin inhibits the reaction [VIP protein results in increased expression of PTGS2 protein]
CTD PMID:17434257 PMID:19189304 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link
G Vwf von Willebrand factor multiple interactions EXP Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein] CTD PMID:23845850 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
G Wasl WASP like actin nucleation promoting factor increases expression ISO Curcumin results in increased expression of WASL mRNA CTD PMID:18200517 NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022
JBrowse link
G Wif1 Wnt inhibitory factor 1 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [bisphenol A results in increased expression of WIF1 protein]
Curcumin results in decreased expression of WIF1 protein
CTD PMID:25963729 NCBI chr 7:56,548,060...56,618,364
Ensembl chr 7:56,548,053...56,618,360
JBrowse link
G Wnt1 Wnt family member 1 increases expression
multiple interactions
EXP Curcumin results in increased expression of WNT1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT1 mRNA]
CTD PMID:25963729 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
G Wnt3 Wnt family member 3 increases expression
multiple interactions
EXP Curcumin results in increased expression of WNT3 mRNA; Curcumin results in increased expression of WNT3 protein
Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT3 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT3 protein]
CTD PMID:25963729 NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099
JBrowse link
G Wt1 WT1 transcription factor decreases expression ISO Curcumin results in decreased expression of WT1 mRNA; Curcumin results in decreased expression of WT1 protein CTD PMID:18034345 PMID:19196508 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases stability
multiple interactions
ISO Curcumin results in decreased stability of WWTR1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of WWTR1 protein]; Curcumin results in decreased expression of and affects the localization of WWTR1 protein; Curcumin results in increased phosphorylation of and results in decreased stability of WWTR1 protein; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 protein]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 protein]; WWTR1 protein inhibits the reaction [Curcumin results in increased susceptibility to Cisplatin]
CTD PMID:33539684 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
JBrowse link
G Xaf1 XIAP associated factor 1 increases expression ISO Curcumin results in increased expression of XAF1 mRNA; Curcumin results in increased expression of XAF1 protein CTD PMID:21594647 NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Curcumin results in increased expression of XBP1 mRNA CTD PMID:29723631 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Curcumin inhibits the reaction [Indomethacin results in increased activity of XDH protein] CTD PMID:17351913 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases expression
ISO [arsenic trioxide co-treated with Curcumin] results in decreased expression of XIAP protein; [Curcumin co-treated with Doxorubicin] affects the expression of XIAP mRNA; arsenic trioxide promotes the reaction [Curcumin results in decreased expression of XIAP protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of XIAP protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Curcumin promotes the reaction [lonidamine results in decreased expression of XIAP protein]; lonidamine promotes the reaction [Curcumin results in decreased expression of XIAP protein]
Curcumin analog results in decreased expression of XIAP mRNA; Curcumin results in decreased expression of XIAP mRNA; Curcumin results in decreased expression of XIAP protein
CTD PMID:15911101 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 More... NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xpo1 exportin 1 multiple interactions ISO Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein] CTD PMID:21519798 NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 protein] CTD PMID:21332098 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 multiple interactions ISO Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 protein] CTD PMID:21332098 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression ISO Curcumin results in decreased expression of XRCC5 mRNA CTD PMID:17596214 NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 decreases expression ISO Curcumin results in decreased expression of XRCC6 mRNA CTD PMID:17596214 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
JBrowse link
G Ypel3 yippee-like 3 decreases expression ISO Curcumin results in decreased expression of YPEL3 mRNA CTD PMID:17198877 NCBI chr 1:181,384,385...181,387,706
Ensembl chr 1:181,384,357...181,387,705
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon decreases expression ISO Curcumin results in decreased expression of YWHAE mRNA; Curcumin results in decreased expression of YWHAE protein CTD PMID:19294764 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
JBrowse link
G Zfhx3 zinc finger homeobox 3 decreases expression ISO Curcumin results in decreased expression of ZFHX3 mRNA CTD PMID:17198877 NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771
JBrowse link
G Zfp287 zinc finger protein 287 increases expression ISO Curcumin results in increased expression of ZNF287 mRNA CTD PMID:18421014 NCBI chr10:47,395,650...47,415,610
Ensembl chr10:47,397,285...47,439,755
JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 decreases expression ISO Curcumin results in decreased expression of ZFP36L1 mRNA CTD PMID:15713895 NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
JBrowse link
demethoxycurcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO demethoxycurcumin results in decreased activity of ABCC1 protein CTD PMID:15885658 PMID:16021489 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO demethoxycurcumin results in decreased activity of ABCC2 protein CTD PMID:15885658 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Ache acetylcholinesterase decreases activity EXP demethoxycurcumin results in decreased activity of ACHE protein CTD PMID:18930076 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO demethoxycurcumin results in increased phosphorylation of AKT1 protein
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]
AKT1 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]
CTD PMID:17535857 PMID:35752269 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases secretion
ISO demethoxycurcumin inhibits the reaction [APP protein binds to APP protein]
demethoxycurcumin results in decreased secretion of APP protein
CTD PMID:19715544 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein] CTD PMID:26264395 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Bak1 BCL2-antagonist/killer 1 decreases expression ISO demethoxycurcumin results in decreased expression of BAK1 mRNA CTD PMID:33582110 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO demethoxycurcumin results in increased expression of BAX protein CTD PMID:34291863 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO demethoxycurcumin results in decreased expression of BCL2 protein CTD PMID:34291863 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO demethoxycurcumin results in decreased expression of BCL2L1 mRNA; demethoxycurcumin results in decreased expression of BCL2L1 protein CTD PMID:33582110 PMID:34291863 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO demethoxycurcumin results in decreased expression of BIRC5 protein CTD PMID:34291863 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp12 caspase 12 multiple interactions ISO demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form] CTD PMID:26264395 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases expression
ISO demethoxycurcumin inhibits the reaction [Peroxynitrous Acid results in increased activity of CASP3 protein]
demethoxycurcumin results in increased cleavage of CASP3 protein
demethoxycurcumin results in decreased expression of CASP3 mRNA
CTD PMID:19188863 PMID:33582110 PMID:34291863 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 decreases expression ISO demethoxycurcumin results in decreased expression of CASP8 mRNA CTD PMID:33582110 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
decreases expression
ISO demethoxycurcumin results in increased activity of CASP9 protein
demethoxycurcumin results in increased cleavage of CASP9 protein
demethoxycurcumin results in decreased expression of CASP9 mRNA
CTD PMID:33582110 PMID:34291863 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO demethoxycurcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein] CTD PMID:23386263 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO demethoxycurcumin results in decreased expression of CDK4 protein CTD PMID:34291863 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO demethoxycurcumin results in increased expression of CDKN1A mRNA CTD PMID:33582110 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] CTD PMID:26264395 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26264395 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases response to substance
multiple interactions
ISO ERBB2 protein results in increased susceptibility to demethoxycurcumin
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [demethoxycurcumin results in increased degradation of ERBB2 protein]; demethoxycurcumin results in decreased expression of and results in increased degradation of ERBB2 protein
CTD PMID:34291863 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein] CTD PMID:26264395 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO demethoxycurcumin results in increased expression of GADD45A mRNA CTD PMID:33582110 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO demethoxycurcumin results in increased expression of GCLM mRNA
demethoxycurcumin results in increased expression of GCLM mRNA; demethoxycurcumin results in increased expression of GCLM protein
CTD PMID:17535857 PMID:19188863 PMID:23386263 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [demethoxycurcumin co-treated with bisdemethoxycurcumin] results in increased expression of HMOX1 mRNA; AKT1 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; KEAP1 protein inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; PRKCD protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]
demethoxycurcumin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HMOX1 mRNA]
demethoxycurcumin results in increased expression of HMOX1 mRNA; demethoxycurcumin results in increased expression of HMOX1 protein
CTD PMID:17535857 PMID:19188863 PMID:23386263 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] CTD PMID:26264395 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ins2 insulin 2 increases secretion ISO demethoxycurcumin results in increased secretion of INS protein CTD PMID:19188863 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kdr kinase insert domain receptor affects expression
multiple interactions
ISO demethoxycurcumin affects the expression of KDR mRNA
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]
CTD PMID:17960570 PMID:35752269 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO KEAP1 protein inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA] CTD PMID:17535857 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO demethoxycurcumin results in increased phosphorylation of MAPK1 protein
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:17535857 PMID:35752269 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO demethoxycurcumin results in increased phosphorylation of MAPK3 protein
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:17535857 PMID:35752269 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression ISO demethoxycurcumin results in decreased expression of MMP14 protein CTD PMID:18495463 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO demethoxycurcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form CTD PMID:18495463 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO demethoxycurcumin results in decreased secretion of and results in decreased activity of MMP9 protein CTD PMID:18495463 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:23386263 NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions
ISO demethoxycurcumin affects the localization of NFE2L2 protein
[demethoxycurcumin co-treated with bisdemethoxycurcumin] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]
CTD PMID:17535857 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18449507 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:18449507 PMID:18838107 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO demethoxycurcumin results in increased expression of NQO1 mRNA; demethoxycurcumin results in increased expression of NQO1 protein CTD PMID:17535857 PMID:19188863 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OLR1 mRNA] CTD PMID:23386263 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO demethoxycurcumin results in increased cleavage of PARP1 protein
Wortmannin promotes the reaction [demethoxycurcumin results in increased cleavage of PARP1 protein]
CTD PMID:34291863 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression EXP demethoxycurcumin results in increased expression of PECAM1 protein CTD PMID:17960570 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Plau plasminogen activator, urokinase decreases secretion ISO demethoxycurcumin results in decreased secretion of PLAU protein CTD PMID:18495463 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO demethoxycurcumin binds to PPARG protein CTD PMID:15713005 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO PRKCD protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA] CTD PMID:17535857 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:18449507 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO demethoxycurcumin results in decreased expression of RAF1 protein CTD PMID:34291863 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression ISO demethoxycurcumin results in decreased expression of TIMP2 protein CTD PMID:18495463 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:18838107 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A affects expression
multiple interactions
ISO demethoxycurcumin affects the expression of VEGFA mRNA
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:17960570 PMID:35752269 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wt1 WT1 transcription factor decreases expression ISO demethoxycurcumin results in decreased expression of WT1 mRNA; demethoxycurcumin results in decreased expression of WT1 protein CTD PMID:18034345 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO demethoxycurcumin results in decreased expression of XIAP protein CTD PMID:34291863 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
dibenzoylmethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO dibenzoylmethane results in increased expression of ABCG2 protein CTD PMID:17077187 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO dibenzoylmethane results in decreased phosphorylation of AKT1 protein
[dibenzoylmethane co-treated with sulforaphane] results in decreased phosphorylation of AKT1 protein
CTD PMID:17942926 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein] CTD PMID:21523861 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO dibenzoylmethane results in increased expression of BAX protein CTD PMID:17942926 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA] CTD PMID:16051634 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp9 caspase 9 multiple interactions ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein] CTD PMID:21523861 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression
multiple interactions
ISO dibenzoylmethane results in increased expression of CBR3 mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of CBR3 mRNA
CTD PMID:17942926 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO dibenzoylmethane results in decreased expression of CCND1 protein CTD PMID:17942926 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO dibenzoylmethane results in decreased expression of CDKN1A protein CTD PMID:17942926 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Clu clusterin decreases expression
multiple interactions
ISO dibenzoylmethane results in decreased expression of CLU mRNA
[sulforaphane co-treated with dibenzoylmethane] results in decreased expression of CLU mRNA
CTD PMID:17942926 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity
multiple interactions
increases expression
ISO dibenzoylmethane results in increased activity of EPHX1 protein
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of EPHX1 mRNA
dibenzoylmethane results in increased expression of EPHX1 mRNA
CTD PMID:3621371 PMID:17942926 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer] CTD PMID:16051634 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO dibenzoylmethane results in increased expression of GCLC mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA
CTD PMID:17942926 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression
multiple interactions
ISO dibenzoylmethane results in increased expression of GSTM1 mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GSTM1 mRNA
CTD PMID:17942926 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions
increases expression
ISO [sulforaphane co-treated with dibenzoylmethane] results in increased expression of GSTM3 mRNA
dibenzoylmethane results in increased expression of GSTM3 mRNA
CTD PMID:17942926 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of HRAS mRNA] CTD PMID:16051634 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer] CTD PMID:16051634 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
decreases response to substance
ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased abundance of Reactive Oxygen Species]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein]
ODC1 protein results in decreased susceptibility to dibenzoylmethane
CTD PMID:21523861 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO [sulforaphane co-treated with dibenzoylmethane] results in increased expression of PTGR1 mRNA CTD PMID:17942926 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO dibenzoylmethane results in decreased expression of PTGS2 protein CTD PMID:17942926 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of TERT mRNA] CTD PMID:16051634 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
ninhydrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 affects activity ISO Ninhydrin affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
phenindione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Phenindione results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I; [Phenindione results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I metabolite CTD PMID:21613233 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Tp53 tumor protein p53 increases degradation ISO Phenindione results in increased degradation of TP53 protein CTD PMID:14634213 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases activity
multiple interactions
ISO Phenindione results in decreased activity of VKORC1 protein
Phenindione inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
CTD PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity
ISO Phenindione inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Phenindione results in decreased activity of VKORC1L1 protein
CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225
JBrowse link
quinoline yellow term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 decreases expression ISO quinoline yellow results in decreased expression of ESR1 protein CTD PMID:31957441 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
tetrahydrocurcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase affects expression ISO Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice RGD PMID:22212488 RGD:41410880 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO tetrahydrocurcumin inhibits the reaction [APP protein binds to APP protein] CTD PMID:19715544 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Cat catalase multiple interactions
affects expression
EXP
ISO
tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Vincristine results in decreased expression of CAT protein]
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice
tetrahydrocurcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]
CTD
RGD
PMID:17076682 PMID:25869292 PMID:26102012 PMID:30423402 PMID:22212488 RGD:41410880 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA] CTD PMID:26102010 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein] CTD PMID:26102010 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression ISO tetrahydrocurcumin results in decreased expression of CYP2B10 mRNA CTD PMID:26102010 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] CTD PMID:26102010 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein] CTD PMID:30423402 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:30423402 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein] CTD PMID:20696151 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein] CTD PMID:20696151 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein] CTD PMID:20696151 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP2 protein] CTD PMID:25502771 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
affects expression
ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP9 protein]
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice
CTD
RGD
PMID:25502771 PMID:22212488 RGD:41410880 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects expression ISO Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice RGD PMID:22212488 RGD:41410880 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects expression ISO Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice RGD PMID:22212488 RGD:41410880 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein] CTD PMID:25502771 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in decreased expression of NOS3 protein] CTD PMID:25502771 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO tetrahydrocurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
tetrahydrocurcumin results in decreased expression of PTGS2 mRNA
CTD PMID:18507010 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP tetrahydrocurcumin inhibits the reaction [Vincristine results in increased expression of TNF protein] CTD PMID:26102012 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      group 19791
        inorganic group 19383
          oxo group 18879
            organic oxo compound 18879
              carbonyl compound 18879
                ketone 17180
                  diketone 1259
                    beta-diketone 946
                      (22Z)-Hentriacont-22-ene-2,4-dione 0
                      1,3-indandione 0
                      1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione + 0
                      1-(2-aminophenyl)decane-1,3-dione 0
                      10,12-Heptacosanedione 0
                      10,12-Pentacosanedione 0
                      10,12-Tritriacontanedione 0
                      12,14-Nonacosanedione 0
                      14,16-Nonacosanedione 0
                      2'-O-methyllicodione 0
                      2,4,4',6-tetrahydroxydibenzoylmethane 0
                      2,4-Heptadecanedione 0
                      2,4-Nonanedione 0
                      2,4-dioxopentanedioic acid 0
                      2-Acetylcycloheptanone 0
                      2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione 0
                      2-[(4,4-dimethyl-2,6-dioxocyclohexyl)methyl]-5,5-dimethylcyclohexane-1,3-dione 0
                      2-[1-(2,6-dioxocyclohexyl)-3-phenylprop-2-ynyl]cyclohexane-1,3-dione 0
                      2-cyano-3-cyclopropyl-1-(2-mesyl-4-trifluoromethylphenyl)propan-1,3-dione 0
                      3,5-Heptanedione, 4-ethyl-2,2,6,6-tetramethyl- 0
                      3,5-dioxooctanedioic acid 0
                      3,6-dihydroxycyclohexane-1,2,4,5-tetrone 0
                      3-Ethylundecan-2,4-dione 0
                      3-Methyl-2,4-nonanedione 0
                      3-\{1-[(E)-Allyloxyimino]-butyl\}-4-hydroxy-6,6-dimethyl-2-oxo-cyclohex-3-enecarboxylic acid methyl ester 0
                      3-dehydro-scyllo-inosose 0
                      3-fumarylpyruvic acid 0
                      3-hydroxy-2,4-dioxopentyl phosphate 0
                      3-maleylpyruvic acid 0
                      3-undecylcyclohexane-1,2,4,5-tetrone 0
                      4,6-Docosanedione 0
                      4,6-Icosanedione 0
                      4,6-Nonadecanedione 0
                      4,6-Tetracosanedione 0
                      4,6-dioxohept-2-enedioic acid + 0
                      4,6-dioxoheptanoic acid 4
                      4-(2-aminophenyl)-2,4-dioxobutanoic acid 0
                      4-(3-methyl-5-isoxazolyl)-5-phenylcyclohexane-1,3-dione 0
                      4-Methylheptane-3,5-dione 0
                      4-[4-(3,5-dioxohexyl)phenylcarbamoyl]butyric acid 0
                      4-fumarylacetoacetic acid 0
                      4-maleylacetoacetic acid 0
                      5,5-dimethyl-2-[(trifluoromethyl)sulfanyl]-1,3-cyclohexanedione 0
                      5,7-Docosanedione 0
                      5,7-icosanedione 0
                      5-(2,2-diferuloylethen-1-yl)thalidomide 0
                      5-(2-furanyl)cyclohexane-1,3-dione 0
                      5-(hydroxymethyl)-3-(1-oxohexadecyl)oxolane-2,4-dione 0
                      5-Ethylpentadecane-2,4-dione 0
                      5-ethylundecane-2,4-dione 0
                      5-hydroxy-2,4-dioxopentanoic acid 0
                      6,8-Docosanedione 0
                      6,8-icosanedione 0
                      6-Methylheptan-2,4-dione 0
                      6-[(2E,4E)-4,6-dimethylocta-2,4-dienoyl]-2,3-dihydroxy-2-methylcyclohexan-1-one 0
                      7,9-Docosanedione 0
                      7,9-Triacontanedione 0
                      7-Ethylheptadecane-4,6-dione 0
                      7-Ethylpentadecane-4,6-dione 0
                      7-Ethylundecane-4,6-dione 0
                      8,10-Hentriacontanedione 0
                      Adhumulinic acid 0
                      Cohulupone 0
                      Cryptocin 0
                      Demethylbisorbibutenolide 0
                      Erucoylacetone 0
                      Henicosane-4,6-dione 0
                      Henicosane-6,8-dione 0
                      Heptacosane-4,6-dione 0
                      Heptacosane-6,8-dione 0
                      Hexacosane-7,9-dione 0
                      LSM-26950 0
                      Nervonoylacetone 0
                      Penicillone A 0
                      Pentacosane-6,8-dione 0
                      Tricosane-4,6-dione 0
                      Tsibulin 1 0
                      Tsibulin 2 0
                      [10]-Gingerdione 0
                      [12]-Gingerdione 0
                      [6]-Gingerdione 0
                      [8]-Gingerdione 0
                      acetylacetone 0
                      acetylpyruvic acid + 0
                      anisindione 0
                      azanigerone A 0
                      azanigerone B 0
                      azanigerone C 0
                      azanigerone D 0
                      azanigerone E 0
                      azanigerone F 0
                      berkeleydione 0
                      berkeleyone A 0
                      berkeleyone B 0
                      berkeleyone C 0
                      berkeleytrione 0
                      bicyclo[2.2.2]octane-2,6-dione 0
                      bicyclopyrone 0
                      bisdemethoxycurcumin 39
                      clethodim 0
                      curcumin + 933
                      cyclohexane-1,3-dione 0
                      cyclopentane-1,3-dione 0
                      cycloxydim 0
                      dehydrocitreoisocoumarin 0
                      demethoxycurcumin 52
                      dibenzoylmethane + 21
                      fleephilone 0
                      fujikurin D 0
                      hentriacontane-14,16-dione 0
                      licodione + 0
                      mitorubrin + 0
                      ninhydrin 1
                      nonane-4,6-dione 0
                      ochrocarpinone A 0
                      ochrocarpinone B 0
                      ochrocarpinone C 0
                      phenindione 4
                      quinoline yellow 1
                      tenuazonic acid 0
                      tetrahydrocurcumin 20
                      tetrahydrodemethoxycurcumin 0
                      tetrahydroxycurcumin 0
                      triacetic acid 0
                      tritriacontane-16,18-dione 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19730
                        carbon atom 19727
                          organic molecular entity 19727
                            organic group 18947
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18879
                                    carbonyl compound 18879
                                      ketone 17180
                                        diketone 1259
                                          beta-diketone 946
                                            (22Z)-Hentriacont-22-ene-2,4-dione 0
                                            1,3-indandione 0
                                            1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione + 0
                                            1-(2-aminophenyl)decane-1,3-dione 0
                                            10,12-Heptacosanedione 0
                                            10,12-Pentacosanedione 0
                                            10,12-Tritriacontanedione 0
                                            12,14-Nonacosanedione 0
                                            14,16-Nonacosanedione 0
                                            2'-O-methyllicodione 0
                                            2,4,4',6-tetrahydroxydibenzoylmethane 0
                                            2,4-Heptadecanedione 0
                                            2,4-Nonanedione 0
                                            2,4-dioxopentanedioic acid 0
                                            2-Acetylcycloheptanone 0
                                            2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione 0
                                            2-[(4,4-dimethyl-2,6-dioxocyclohexyl)methyl]-5,5-dimethylcyclohexane-1,3-dione 0
                                            2-[1-(2,6-dioxocyclohexyl)-3-phenylprop-2-ynyl]cyclohexane-1,3-dione 0
                                            2-cyano-3-cyclopropyl-1-(2-mesyl-4-trifluoromethylphenyl)propan-1,3-dione 0
                                            3,5-Heptanedione, 4-ethyl-2,2,6,6-tetramethyl- 0
                                            3,5-dioxooctanedioic acid 0
                                            3,6-dihydroxycyclohexane-1,2,4,5-tetrone 0
                                            3-Ethylundecan-2,4-dione 0
                                            3-Methyl-2,4-nonanedione 0
                                            3-\{1-[(E)-Allyloxyimino]-butyl\}-4-hydroxy-6,6-dimethyl-2-oxo-cyclohex-3-enecarboxylic acid methyl ester 0
                                            3-dehydro-scyllo-inosose 0
                                            3-fumarylpyruvic acid 0
                                            3-hydroxy-2,4-dioxopentyl phosphate 0
                                            3-maleylpyruvic acid 0
                                            3-undecylcyclohexane-1,2,4,5-tetrone 0
                                            4,6-Docosanedione 0
                                            4,6-Icosanedione 0
                                            4,6-Nonadecanedione 0
                                            4,6-Tetracosanedione 0
                                            4,6-dioxohept-2-enedioic acid + 0
                                            4,6-dioxoheptanoic acid 4
                                            4-(2-aminophenyl)-2,4-dioxobutanoic acid 0
                                            4-(3-methyl-5-isoxazolyl)-5-phenylcyclohexane-1,3-dione 0
                                            4-Methylheptane-3,5-dione 0
                                            4-[4-(3,5-dioxohexyl)phenylcarbamoyl]butyric acid 0
                                            4-fumarylacetoacetic acid 0
                                            4-maleylacetoacetic acid 0
                                            5,5-dimethyl-2-[(trifluoromethyl)sulfanyl]-1,3-cyclohexanedione 0
                                            5,7-Docosanedione 0
                                            5,7-icosanedione 0
                                            5-(2,2-diferuloylethen-1-yl)thalidomide 0
                                            5-(2-furanyl)cyclohexane-1,3-dione 0
                                            5-(hydroxymethyl)-3-(1-oxohexadecyl)oxolane-2,4-dione 0
                                            5-Ethylpentadecane-2,4-dione 0
                                            5-ethylundecane-2,4-dione 0
                                            5-hydroxy-2,4-dioxopentanoic acid 0
                                            6,8-Docosanedione 0
                                            6,8-icosanedione 0
                                            6-Methylheptan-2,4-dione 0
                                            6-[(2E,4E)-4,6-dimethylocta-2,4-dienoyl]-2,3-dihydroxy-2-methylcyclohexan-1-one 0
                                            7,9-Docosanedione 0
                                            7,9-Triacontanedione 0
                                            7-Ethylheptadecane-4,6-dione 0
                                            7-Ethylpentadecane-4,6-dione 0
                                            7-Ethylundecane-4,6-dione 0
                                            8,10-Hentriacontanedione 0
                                            Adhumulinic acid 0
                                            Cohulupone 0
                                            Cryptocin 0
                                            Demethylbisorbibutenolide 0
                                            Erucoylacetone 0
                                            Henicosane-4,6-dione 0
                                            Henicosane-6,8-dione 0
                                            Heptacosane-4,6-dione 0
                                            Heptacosane-6,8-dione 0
                                            Hexacosane-7,9-dione 0
                                            LSM-26950 0
                                            Nervonoylacetone 0
                                            Penicillone A 0
                                            Pentacosane-6,8-dione 0
                                            Tricosane-4,6-dione 0
                                            Tsibulin 1 0
                                            Tsibulin 2 0
                                            [10]-Gingerdione 0
                                            [12]-Gingerdione 0
                                            [6]-Gingerdione 0
                                            [8]-Gingerdione 0
                                            acetylacetone 0
                                            acetylpyruvic acid + 0
                                            anisindione 0
                                            azanigerone A 0
                                            azanigerone B 0
                                            azanigerone C 0
                                            azanigerone D 0
                                            azanigerone E 0
                                            azanigerone F 0
                                            berkeleydione 0
                                            berkeleyone A 0
                                            berkeleyone B 0
                                            berkeleyone C 0
                                            berkeleytrione 0
                                            bicyclo[2.2.2]octane-2,6-dione 0
                                            bicyclopyrone 0
                                            bisdemethoxycurcumin 39
                                            clethodim 0
                                            curcumin + 933
                                            cyclohexane-1,3-dione 0
                                            cyclopentane-1,3-dione 0
                                            cycloxydim 0
                                            dehydrocitreoisocoumarin 0
                                            demethoxycurcumin 52
                                            dibenzoylmethane + 21
                                            fleephilone 0
                                            fujikurin D 0
                                            hentriacontane-14,16-dione 0
                                            licodione + 0
                                            mitorubrin + 0
                                            ninhydrin 1
                                            nonane-4,6-dione 0
                                            ochrocarpinone A 0
                                            ochrocarpinone B 0
                                            ochrocarpinone C 0
                                            phenindione 4
                                            quinoline yellow 1
                                            tenuazonic acid 0
                                            tetrahydrocurcumin 20
                                            tetrahydrodemethoxycurcumin 0
                                            tetrahydroxycurcumin 0
                                            triacetic acid 0
                                            tritriacontane-16,18-dione 0
paths to the root