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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetrahydrocurcumin
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Accession:CHEBI:67263 term browser browse the term
Definition:A beta-diketone that is curcumin in which both of the double bonds have been reduced to single bonds.
Synonyms:exact_synonym: 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
 related_synonym: 1,7-bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione;   Formula=C21H24O6;   InChI=1S/C21H24O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,24-25H,3-4,7-8,13H2,1-2H3;   InChIKey=LBTVHXHERHESKG-UHFFFAOYSA-N;   SMILES=COc1cc(CCC(=O)CC(=O)CCc2ccc(O)c(OC)c2)ccc1O
 xref: CAS:36062-04-1;   HMDB:HMDB0005789
 xref_mesh: MESH:C096277
 xref: MetaCyc:CPD-13315;   PMID:21116204;   PMID:21467222;   PMID:21887819;   PMID:21928294;   PMID:22072109;   PMID:22156377;   PMID:22212488;   PMID:22574459;   Reaxys:3485469


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tetrahydrocurcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase affects expression ISO Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice RGD PMID:22212488 RGD:41410880 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO tetrahydrocurcumin inhibits the reaction [APP protein binds to APP protein] CTD PMID:19715544 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Cat catalase multiple interactions
affects expression
EXP
ISO
tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Vincristine results in decreased expression of CAT protein]
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice
tetrahydrocurcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]
CTD PMID:17076682 PMID:25869292 PMID:26102012 PMID:30423402, PMID:22212488 RGD:41410880 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA] CTD PMID:26102010 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein] CTD PMID:26102010 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression ISO tetrahydrocurcumin results in decreased expression of CYP2B10 mRNA CTD PMID:26102010 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression ISO tetrahydrocurcumin results in decreased expression of CYP2B9 mRNA CTD PMID:26102010 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] CTD PMID:26102010 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein] CTD PMID:30423402 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:30423402 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein] CTD PMID:20696151 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein] CTD PMID:20696151 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein] CTD PMID:20696151 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP2 protein] CTD PMID:25502771 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
affects expression
ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP9 protein]
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice
CTD PMID:25502771, PMID:22212488 RGD:41410880 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects expression ISO Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice RGD PMID:22212488 RGD:41410880 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects expression ISO Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice RGD PMID:22212488 RGD:41410880 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein] CTD PMID:25502771 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in decreased expression of NOS3 protein] CTD PMID:25502771 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO tetrahydrocurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
tetrahydrocurcumin results in decreased expression of PTGS2 mRNA
CTD PMID:18507010 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP tetrahydrocurcumin inhibits the reaction [Vincristine results in increased expression of TNF protein] CTD PMID:26102012 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        biochemical role 19360
          metabolite 19341
            tetrahydrocurcumin 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      carboxylic acid 18142
                                        monocarboxylic acid 17513
                                          alpha,beta-unsaturated monocarboxylic acid 11394
                                            cinnamic acids 2385
                                              hydroxycinnamic acid 1260
                                                monohydroxycinnamic acid 926
                                                  ferulic acids 920
                                                    ferulic acid 920
                                                      curcumin 874
                                                        tetrahydrocurcumin 21
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