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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 3.2.1.45 (glucosylceramidase) inhibitor
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Accession:CHEBI:67230 term browser browse the term
Definition:An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of glucosylceramidase (EC 3.2.1.45).
Synonyms:related_synonym: D-glucosyl-N-acylsphingosine glucohydrolase inhibitor;   D-glucosyl-N-acylsphingosine glucohydrolase inhibitors;   EC 3.2.1.45 (glucosylceramidase) inhibitors;   EC 3.2.1.45 inhibitor;   EC 3.2.1.45 inhibitors;   GlcCer-beta-glucosidase inhibitor;   GlcCer-beta-glucosidase inhibitors;   acid beta-glucosidase inhibitor;   acid beta-glucosidase inhibitors;   beta-D-glucocerebrosidase inhibitor;   beta-D-glucocerebrosidase inhibitors;   beta-glucosylceramidase inhibitor;   beta-glucosylceramidase inhibitors;   ceramide glucosidase inhibitor;   ceramide glucosidase inhibitors;   glucocerebrosidase inhibitor;   glucocerebrosidase inhibitors;   glucosphingosine glucosylhydrolase inhibitor;   glucosphingosine glucosylhydrolase inhibitors;   glucosylceramidase inhibitor;   glucosylceramidase inhibitors;   glucosylcerebrosidase inhibitor;   glucosylcerebrosidase inhibitors;   glucosylsphingosine beta-D-glucosidase inhibitor;   glucosylsphingosine beta-D-glucosidase inhibitors;   glucosylsphingosine beta-glucosidase inhibitor;   glucosylsphingosine beta-glucosidase inhibitors;   psychosine hydrolase inhibitor;   psychosine hydrolase inhibitors
 xref: Wikipedia:Glucosylceramidase


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conduritol B epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba1 glucosylceramidase beta 1 multiple interactions
decreases activity		 ISO
EXP		 [conduritol epoxide binds to and results in decreased activity of GBA1 protein] which results in increased expression of SNCA protein
conduritol epoxide analog results in decreased activity of GBA1 protein
[conduritol epoxide binds to and results in decreased activity of GBA1 protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA1 protein] which results in increased expression of SNCA protein		 CTD PMID:9101438 PMID:19576930 NCBI chr 3:89,110,235...89,119,944
Ensembl chr 3:89,110,235...89,116,273 		JBrowse link
G Snca synuclein, alpha multiple interactions EXP
ISO		 [conduritol epoxide binds to and results in decreased activity of GBA1 protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA1 protein] which results in increased expression of SNCA protein CTD PMID:19576930 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biochemical role 21431
          enzyme inhibitor 19894
            EC 3.* (hydrolase) inhibitor 19243
              EC 3.2.* (glycosylase) inhibitor 5233
                EC 3.2.1.* (glycosidase) inhibitor 5233
                  EC 3.2.1.45 (glucosylceramidase) inhibitor 2
                    N-nonyldeoxynojirimycin 0
                    conduritol B epoxide 2
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