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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.2.1.45 (glucosylceramidase) inhibitor
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Accession:CHEBI:67230 term browser browse the term
Definition:An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of glucosylceramidase (EC 3.2.1.45).
Synonyms:related_synonym: D-glucosyl-N-acylsphingosine glucohydrolase inhibitor;   D-glucosyl-N-acylsphingosine glucohydrolase inhibitors;   EC 3.2.1.45 (glucosylceramidase) inhibitors;   EC 3.2.1.45 inhibitor;   EC 3.2.1.45 inhibitors;   GlcCer-beta-glucosidase inhibitor;   GlcCer-beta-glucosidase inhibitors;   acid beta-glucosidase inhibitor;   acid beta-glucosidase inhibitors;   beta-D-glucocerebrosidase inhibitor;   beta-D-glucocerebrosidase inhibitors;   beta-glucosylceramidase inhibitor;   beta-glucosylceramidase inhibitors;   ceramide glucosidase inhibitor;   ceramide glucosidase inhibitors;   glucocerebrosidase inhibitor;   glucocerebrosidase inhibitors;   glucosphingosine glucosylhydrolase inhibitor;   glucosphingosine glucosylhydrolase inhibitors;   glucosylceramidase inhibitor;   glucosylceramidase inhibitors;   glucosylcerebrosidase inhibitor;   glucosylcerebrosidase inhibitors;   glucosylsphingosine beta-D-glucosidase inhibitor;   glucosylsphingosine beta-D-glucosidase inhibitors;   glucosylsphingosine beta-glucosidase inhibitor;   glucosylsphingosine beta-glucosidase inhibitors;   psychosine hydrolase inhibitor;   psychosine hydrolase inhibitors
 xref: Wikipedia:Glucosylceramidase


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conduritol B epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBA glucosylceramidase beta multiple interactions
decreases activity
EXP
ISO
[conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein
[conduritol epoxide binds to and results in decreased activity of GBA protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein
conduritol epoxide analog results in decreased activity of GBA protein
CTD PMID:9101438, PMID:19576930 NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,452...155,244,699
JBrowse link
G SNCA synuclein alpha multiple interactions ISO
EXP
[conduritol epoxide binds to and results in decreased activity of GBA protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein CTD PMID:19576930 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
Ensembl chr 4:89,700,345...89,838,315
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24216
    role 24108
      biological role 24072
        biochemical role 23347
          enzyme inhibitor 21384
            EC 3.* (hydrolase) inhibitor 20602
              EC 3.2.* (glycosylase) inhibitor 5069
                EC 3.2.1.* (glycosidase) inhibitor 5069
                  EC 3.2.1.45 (glucosylceramidase) inhibitor 2
                    N-nonyldeoxynojirimycin 0
                    conduritol B epoxide 2
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