CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: megestrol acetate
Accession: CHEBI:6723
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Definition: A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer.
Synonyms: exact_synonym: 6-methyl-3,20-dioxopregna-4,6-dien-17-yl acetate
related_synonym: 17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione; 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate; 17alpha-Acetoxy-6-dehydro-6-methylprogesterone; 17alpha-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate; 6-Methyl-17alpha-acetoxypregna-4,6-diene-3,20-dione; 6-Methyl-17alpha-hydroxy-delta(sup 6)-progesterone acetate; 6-Methyl-6-dehydro-17alpha-acetoxyprogesterone; 6-Methyl-delta(sup 4,6)-pregnadien-17alpha-ol-3,20-dione acetate; 6-Methyl-delta(sup 6)-dehydro-17alpha-acetoxyprogesterone; BDH 1298; BDH1298; Formula=C24H32O4; InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1; InChIKey=RQZAXGRLVPAYTJ-GQFGMJRRSA-N; Maygace; Megace; Megeron; Megestat; Megestil; Megestin; Niagestin; Ovaban; Ovarid; Pallace; SC-10363; SC10363; SMILES=[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C=C(C)C2=CC(=O)CC[C@]12C; Volidan; magestin
xref: Beilstein:1917291; CAS:595-33-5; DrugBank:DB00351; KEGG:C08151; KEGG:D00952; LIPID_MAPS_instance:LMST02030118
xref_mesh: MESH:D019290
xref: PMCID:PMC7207385; PMID:11986264; PMID:27038209; PMID:27218795; PMID:27639080; PMID:28986550; PMID:29050522; PMID:29095656; PMID:29400904; PMID:29442239; PMID:29542279; PMID:29581752; PMID:30112227; PMID:30157059; PMID:31036192; PMID:31359357; PMID:31451262; PMID:31462353; PMID:31497435; PMID:31961463; PMID:32084501; PMID:32122805; PMID:32652300; PMID:5320316; Patent:GB870286; Patent:US2891079; Patent:US3356573; Patent:US3400137; Wikipedia:Megestrol_acetate
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Abcb11
ATP binding cassette subfamily B member 11
decreases activity
ISO
Megestrol Acetate results in decreased activity of ABCB11 protein
CTD
PMID:23956101
NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
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Ahsa1
activator of Hsp90 ATPase activity 1
increases expression
ISO
Megestrol Acetate results in increased expression of AHSA1 protein
CTD
PMID:16939895
NCBI chr 6:111,296,168...111,304,224
Ensembl chr 6:111,296,417...111,304,224
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Ar
androgen receptor
multiple interactions
ISO
Megestrol Acetate binds to and results in decreased activity of AR protein
CTD
PMID:25752796
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Bcl11b
BAF chromatin remodeling complex subunit BCL11B
multiple interactions
EXP
[Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of BCL11B mRNA
CTD
PMID:22085904
NCBI chr 6:131,834,097...131,927,251
Ensembl chr 6:131,834,097...131,926,272
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Cct6a
chaperonin containing TCP1 subunit 6A
increases expression
ISO
Megestrol Acetate results in increased expression of CCT6A protein
CTD
PMID:16939895
NCBI chr12:30,491,584...30,501,813
Ensembl chr12:30,491,416...30,501,860
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Cldn1
claudin 1
multiple interactions decreases expression
ISO
Megestrol Acetate results in decreased expression of and affects the localization of CLDN1 protein Megestrol Acetate results in decreased expression of CLDN1 mRNA
CTD
PMID:22883527
NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
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Cldn4
claudin 4
multiple interactions decreases expression
ISO
Megestrol Acetate results in decreased expression of and results in increased localization of CLDN4 protein Megestrol Acetate results in decreased expression of CLDN4 mRNA
CTD
PMID:23095775
NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
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Comt
catechol-O-methyltransferase
increases expression
ISO
Megestrol Acetate results in increased expression of COMT protein
CTD
PMID:16939895
NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
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Krt8
keratin 8
increases expression
ISO
Megestrol Acetate results in increased expression of KRT8 protein
CTD
PMID:16939895
NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
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Mmp12
matrix metallopeptidase 12
multiple interactions
EXP
[Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP12 protein
CTD
PMID:22085904
NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
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Mmp3
matrix metallopeptidase 3
multiple interactions
EXP
[Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP3 protein
CTD
PMID:22085904
NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
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Mmp8
matrix metallopeptidase 8
multiple interactions
EXP
[Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP8 protein
CTD
PMID:22085904
NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
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Pgr
progesterone receptor
multiple interactions
ISO
Megestrol Acetate binds to and results in increased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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Ppia
peptidylprolyl isomerase A
decreases expression
ISO
Megestrol Acetate results in decreased expression of PPIA protein
CTD
PMID:16939895
NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
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Rab6a
RAB6A, member RAS oncogene family
increases expression
ISO
Megestrol Acetate results in increased expression of RAB6A protein
CTD
PMID:16939895
NCBI chr 1:165,624,973...165,664,201
Ensembl chr 1:165,625,058...165,664,192
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Sf3a3
splicing factor 3a, subunit 3
increases expression
ISO
Megestrol Acetate results in increased expression of SF3A3 protein
CTD
PMID:16939895
NCBI chr 5:142,702,721...142,722,350
Ensembl chr 5:142,702,685...142,722,341
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Megestrol Acetate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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Tnc
tenascin C
multiple interactions
EXP
[Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of TNC mRNA
CTD
PMID:22085904
NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
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