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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:megestrol acetate
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Accession:CHEBI:6723 term browser browse the term
Definition:A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer.
Synonyms:exact_synonym: 6-methyl-3,20-dioxopregna-4,6-dien-17-yl acetate
 related_synonym: 17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione;   17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate;   17alpha-Acetoxy-6-dehydro-6-methylprogesterone;   17alpha-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate;   6-Methyl-17alpha-acetoxypregna-4,6-diene-3,20-dione;   6-Methyl-17alpha-hydroxy-delta(sup 6)-progesterone acetate;   6-Methyl-6-dehydro-17alpha-acetoxyprogesterone;   6-Methyl-delta(sup 4,6)-pregnadien-17alpha-ol-3,20-dione acetate;   6-Methyl-delta(sup 6)-dehydro-17alpha-acetoxyprogesterone;   BDH 1298;   BDH1298;   Formula=C24H32O4;   InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1;   InChIKey=RQZAXGRLVPAYTJ-GQFGMJRRSA-N;   Maygace;   Megace;   Megeron;   Megestat;   Megestil;   Megestin;   Niagestin;   Ovaban;   Ovarid;   Pallace;   SC-10363;   SC10363;   SMILES=[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C=C(C)C2=CC(=O)CC[C@]12C;   Volidan;   magestin
 xref: Beilstein:1917291;   CAS:595-33-5;   DrugBank:DB00351;   KEGG:C08151;   KEGG:D00952;   LIPID_MAPS_instance:LMST02030118
 xref_mesh: MESH:D019290
 xref: PMCID:PMC7207385;   PMID:11986264;   PMID:27038209;   PMID:27218795;   PMID:27639080;   PMID:28986550;   PMID:29050522;   PMID:29095656;   PMID:29400904;   PMID:29442239;   PMID:29542279;   PMID:29581752;   PMID:30112227;   PMID:30157059;   PMID:31036192;   PMID:31359357;   PMID:31451262;   PMID:31462353;   PMID:31497435;   PMID:31961463;   PMID:32084501;   PMID:32122805;   PMID:32652300;   PMID:5320316;   Patent:GB870286;   Patent:US2891079;   Patent:US3356573;   Patent:US3400137;   Wikipedia:Megestrol_acetate


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megestrol acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Megestrol Acetate results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO Megestrol Acetate results in increased expression of AHSA1 protein CTD PMID:16939895 NCBI chr 6:111,296,168...111,304,224
Ensembl chr 6:111,296,417...111,304,224
JBrowse link
G Ar androgen receptor multiple interactions ISO Megestrol Acetate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bcl11b BAF chromatin remodeling complex subunit BCL11B multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of BCL11B mRNA CTD PMID:22085904 NCBI chr 6:131,834,097...131,927,251
Ensembl chr 6:131,834,097...131,926,272
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression ISO Megestrol Acetate results in increased expression of CCT6A protein CTD PMID:16939895 NCBI chr12:30,491,584...30,501,813
Ensembl chr12:30,491,416...30,501,860
JBrowse link
G Cldn1 claudin 1 multiple interactions
decreases expression
ISO Megestrol Acetate results in decreased expression of and affects the localization of CLDN1 protein
Megestrol Acetate results in decreased expression of CLDN1 mRNA
CTD PMID:22883527 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Cldn4 claudin 4 multiple interactions
decreases expression
ISO Megestrol Acetate results in decreased expression of and results in increased localization of CLDN4 protein
Megestrol Acetate results in decreased expression of CLDN4 mRNA
CTD PMID:23095775 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Megestrol Acetate results in increased expression of COMT protein CTD PMID:16939895 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Krt8 keratin 8 increases expression ISO Megestrol Acetate results in increased expression of KRT8 protein CTD PMID:16939895 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP12 protein CTD PMID:22085904 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP3 protein CTD PMID:22085904 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp8 matrix metallopeptidase 8 multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP8 protein CTD PMID:22085904 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Megestrol Acetate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Ppia peptidylprolyl isomerase A decreases expression ISO Megestrol Acetate results in decreased expression of PPIA protein CTD PMID:16939895 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Rab6a RAB6A, member RAS oncogene family increases expression ISO Megestrol Acetate results in increased expression of RAB6A protein CTD PMID:16939895 NCBI chr 1:165,624,973...165,664,201
Ensembl chr 1:165,625,058...165,664,192
JBrowse link
G Sf3a3 splicing factor 3a, subunit 3 increases expression ISO Megestrol Acetate results in increased expression of SF3A3 protein CTD PMID:16939895 NCBI chr 5:142,702,721...142,722,350
Ensembl chr 5:142,702,685...142,722,341
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Megestrol Acetate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tnc tenascin C multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of TNC mRNA CTD PMID:22085904 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      application 19477
        pharmaceutical 19350
          drug 19350
            antineoplastic agent 17010
              megestrol acetate 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic group 18550
                              organic divalent group 18541
                                organodiyl group 18541
                                  carbonyl group 18447
                                    carbonyl compound 18447
                                      ketone 16192
                                        oxyketone 8647
                                          alpha-oxyketone 8647
                                            alpha-hydroxy ketone 8647
                                              tertiary alpha-hydroxy ketone 8372
                                                megestrol 24
                                                  megestrol acetate 18
paths to the root