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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:megestrol acetate
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Accession:CHEBI:6723 term browser browse the term
Definition:A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer.
Synonyms:exact_synonym: 6-methyl-3,20-dioxopregna-4,6-dien-17-yl acetate
 related_synonym: 17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione;   17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate;   17alpha-Acetoxy-6-dehydro-6-methylprogesterone;   17alpha-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate;   6-Methyl-17alpha-acetoxypregna-4,6-diene-3,20-dione;   6-Methyl-17alpha-hydroxy-delta(sup 6)-progesterone acetate;   6-Methyl-6-dehydro-17alpha-acetoxyprogesterone;   6-Methyl-delta(sup 4,6)-pregnadien-17alpha-ol-3,20-dione acetate;   6-Methyl-delta(sup 6)-dehydro-17alpha-acetoxyprogesterone;   BDH 1298;   BDH1298;   Formula=C24H32O4;   InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1;   InChIKey=RQZAXGRLVPAYTJ-GQFGMJRRSA-N;   Maygace;   Megace;   Megeron;   Megestat;   Megestil;   Megestin;   Niagestin;   Ovaban;   Ovarid;   Pallace;   SC-10363;   SC10363;   SMILES=[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C=C(C)C2=CC(=O)CC[C@]12C;   Volidan;   magestin
 xref: Beilstein:1917291;   CAS:595-33-5;   DrugBank:DB00351;   KEGG:C08151;   KEGG:D00952;   LIPID_MAPS_instance:LMST02030118
 xref_mesh: MESH:D019290
 xref: PMCID:PMC7207385;   PMID:11986264;   PMID:27038209;   PMID:27218795;   PMID:27639080;   PMID:28986550;   PMID:29050522;   PMID:29095656;   PMID:29400904;   PMID:29442239;   PMID:29542279;   PMID:29581752;   PMID:30112227;   PMID:30157059;   PMID:31036192;   PMID:31359357;   PMID:31451262;   PMID:31462353;   PMID:31497435;   PMID:31961463;   PMID:32084501;   PMID:32122805;   PMID:32652300;   PMID:5320316;   Patent:GB870286;   Patent:US2891079;   Patent:US3356573;   Patent:US3400137;   Wikipedia:Megestrol_acetate


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megestrol acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Megestrol Acetate results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO Megestrol Acetate results in increased expression of AHSA1 protein CTD PMID:16939895 NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345 		JBrowse link
G Ar androgen receptor multiple interactions ISO Megestrol Acetate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bcl11b BAF chromatin remodeling complex subunit BCL11B multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of BCL11B mRNA CTD PMID:22085904 NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224 		JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression ISO Megestrol Acetate results in increased expression of CCT6A protein CTD PMID:16939895 NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337 		JBrowse link
G Cldn1 claudin 1 multiple interactions
decreases expression		 ISO Megestrol Acetate results in decreased expression of and affects the localization of CLDN1 protein
Megestrol Acetate results in decreased expression of CLDN1 mRNA		 CTD PMID:22883527 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cldn4 claudin 4 multiple interactions
decreases expression		 ISO Megestrol Acetate results in decreased expression of and results in increased localization of CLDN4 protein
Megestrol Acetate results in decreased expression of CLDN4 mRNA		 CTD PMID:23095775 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Megestrol Acetate results in increased expression of COMT protein CTD PMID:16939895 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein affects the reaction [Megestrol Acetate results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 increases expression
multiple interactions		 ISO Megestrol Acetate results in increased expression of GREB1 mRNA
ESR1 protein affects the reaction [Megestrol Acetate results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Megestrol Acetate results in increased expression of GREB1 mRNA]		 CTD PMID:33405908 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Krt8 keratin 8 increases expression ISO Megestrol Acetate results in increased expression of KRT8 protein CTD PMID:16939895 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728 		JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP12 protein CTD PMID:22085904 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP3 protein CTD PMID:22085904 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp8 matrix metallopeptidase 8 multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP8 protein CTD PMID:22085904 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Megestrol Acetate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppia peptidylprolyl isomerase A decreases expression ISO Megestrol Acetate results in decreased expression of PPIA protein CTD PMID:16939895 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Rab6a RAB6A, member RAS oncogene family increases expression ISO Megestrol Acetate results in increased expression of RAB6A protein CTD PMID:16939895 NCBI chr 1:154,957,870...155,008,922
Ensembl chr 1:154,958,189...154,996,715 		JBrowse link
G Sf3a3 splicing factor 3a, subunit 3 increases expression ISO Megestrol Acetate results in increased expression of SF3A3 protein CTD PMID:16939895 NCBI chr 5:136,967,713...136,987,345
Ensembl chr 5:136,967,691...136,987,361 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions		 ISO Megestrol Acetate results in increased expression of SGK1 mRNA
Fulvestrant inhibits the reaction [Megestrol Acetate results in increased expression of SGK1 mRNA]		 CTD PMID:33405908 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Megestrol Acetate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tnc tenascin C multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of TNC mRNA CTD PMID:22085904 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            antineoplastic agent 17359
              megestrol acetate 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      ketone 16957
                                        oxyketone 8674
                                          alpha-oxyketone 8674
                                            alpha-hydroxy ketone 8674
                                              tertiary alpha-hydroxy ketone 8378
                                                megestrol 27
                                                  megestrol acetate 21
paths to the root