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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:conduritol
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Accession:CHEBI:67218 term browser browse the term
Definition:A tetrol that is cyclohexene in which a hydrogen attached to each of the carbons at positions 3, 4, 5, and 6 is replaced by a hydroxy group. The group consists of six possible diastereoisomers, known as conduritols A to F, some of which can exist as two distinct enantiomers.
Synonyms:exact_synonym: cyclohex-5-ene-1,2,3,4-tetrol
 related_synonym: Formula=C6H10O4;   InChI=1S/C6H10O4/c7-3-1-2-4(8)6(10)5(3)9/h1-10H;   InChIKey=LRUBQXAKGXQBHA-UHFFFAOYSA-N;   SMILES=OC1C=CC(O)C(O)C1O
 xref: PMID:12003543;   PMID:16267592;   PMID:21630704;   Wikipedia:Conduritol



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conduritol B epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba glucosylceramidase beta multiple interactions
decreases activity
ISO
EXP
[conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein
[conduritol epoxide binds to and results in decreased activity of GBA protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein
conduritol epoxide analog results in decreased activity of GBA protein
CTD PMID:9101438 PMID:19576930 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Snca synuclein alpha multiple interactions ISO [conduritol epoxide binds to and results in decreased activity of GBA protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein CTD PMID:19576930 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    chemical entity 20088
      molecular entity 20058
        polyatomic entity 20018
          heteroatomic molecular entity 19924
            hydroxides 19454
              organic hydroxy compound 19017
                polyol 11024
                  cyclitol 7463
                    conduritol 2
                      (+)-conduritol B + 2
                      (-)-conduritol B + 2
                      conduritol A 0
                      conduritol epoxide + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    main group molecular entity 19960
                      s-block molecular entity 19784
                        hydrogen molecular entity 19777
                          hydrides 19115
                            organic hydride 18675
                              organic fundamental parent 18657
                                hydrocarbon 18408
                                  olefin 8888
                                    cyclic olefin 410
                                      monocyclic olefin 407
                                        cycloalkene 400
                                          cyclohexene 3
                                            conduritol 2
                                              (+)-conduritol B + 2
                                              (-)-conduritol B + 2
                                              conduritol A 0
                                              conduritol epoxide + 2
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