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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mefenamic acid
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Accession:CHEBI:6717 term browser browse the term
Definition:An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
Synonyms:exact_synonym: 2-[(2,3-dimethylphenyl)amino]benzoic acid
 related_synonym: CI-473;   CN-35355;   Formula=C15H15NO2;   INF-3355;   InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18);   InChIKey=HYYBABOKPJLUIN-UHFFFAOYSA-N;   Mefenaminsaeure;   N-(2,3-xylyl)-2-aminobenzoic acid;   N-2,3-xylylanthranilic acid;   Ponstel;   SMILES=Cc1cccc(Nc2ccccc2C(O)=O)c1C;   acide mefenamique;   acido mefenamico;   acidum mefenamicum
 xref: CAS:61-68-7;   DrugBank:DB00784;   Drug_Central:1663;   HMDB:HMDB0014922;   KEGG:C02168;   KEGG:D00151;   LINCS:LSM-4085
 xref_mesh: MESH:D008528
 xref: PDBeChem:ID8;   PMID:14001132;   PMID:17330662;   PMID:22275128;   PMID:22369458;   PMID:23402341;   PMID:23494912;   PMID:23656341;   PMID:2684858;   PMID:28166217;   PMID:3304401;   PMID:4212650;   PMID:425903;   PMID:4916242;   PMID:5286553;   PMID:577447;   PMID:6155061;   Patent:BE605302;   Patent:US3138636;   Reaxys:2216243;   Wikipedia:Mefenamic_acid


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mefenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Mefenamic Acid analog results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Mefenamic Acid analog results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Mefenamic Acid analog results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alb albumin multiple interactions
affects binding		 ISO Mefenamic Acid inhibits the reaction [Valproic Acid binds to ALB protein]
Mefenamic Acid binds to ALB protein		 CTD PMID:8946661 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases glutathionylation
increases hydroxylation		 ISO CYP1A1 protein results in increased glutathionylation of Mefenamic Acid analog
CYP1A1 protein results in increased hydroxylation of Mefenamic Acid		 CTD PMID:25372302 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases glutathionylation
increases hydroxylation
multiple interactions
increases oxidation		 ISO Mefenamic Acid results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased glutathionylation of Mefenamic Acid analog
CYP1A2 protein results in increased hydroxylation of Mefenamic Acid
SOD1 protein inhibits the reaction [CYP1A2 protein results in increased oxidation of Mefenamic Acid]		 CTD PMID:18816299 PMID:25372302 PMID:33259822 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Mefenamic Acid results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of Mefenamic Acid CTD PMID:25372302 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation
increases glutathionylation		 ISO CYP3A4 protein results in increased hydroxylation of Mefenamic Acid
CYP3A4 protein results in increased glutathionylation of Mefenamic Acid analog		 CTD PMID:25372302 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases glutathionylation ISO GSTA1 protein results in increased glutathionylation of Mefenamic Acid analog CTD PMID:25372302 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases glutathionylation ISO GSTA2 protein results in increased glutathionylation of Mefenamic Acid analog CTD PMID:25372302 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases glutathionylation ISO GSTM1 protein results in increased glutathionylation of Mefenamic Acid analog CTD PMID:25372302 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases glutathionylation ISO GSTM3 protein results in increased glutathionylation of Mefenamic Acid analog CTD PMID:25372302 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases glutathionylation ISO GSTP1 protein results in increased glutathionylation of Mefenamic Acid analog CTD PMID:25372302 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity
increases expression		 ISO Mefenamic Acid results in increased activity of HPGD protein
Mefenamic Acid results in increased expression of HPGD mRNA		 CTD PMID:19501039 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Il1b interleukin 1 beta decreases secretion ISO Mefenamic Acid results in decreased secretion of IL1B protein CTD PMID:10393680 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases secretion ISO Mefenamic Acid results in decreased secretion of IL6 protein CTD PMID:10393680 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnk10 potassium two pore domain channel subfamily K member 10 multiple interactions ISO Mefenamic Acid promotes the reaction [KCNK10 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 6:117,690,052...117,826,120
Ensembl chr 6:117,694,222...117,825,695 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 multiple interactions ISO Mefenamic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435 		JBrowse link
G Kcnk4 potassium two pore domain channel subfamily K member 4 multiple interactions ISO Mefenamic Acid promotes the reaction [KCNK4 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 1:204,117,941...204,129,494
Ensembl chr 1:204,114,572...204,125,925 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Mefenamic Acid affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Mefenamic Acid inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol] CTD PMID:29281794 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO Mefenamic Acid inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]; NQO2 protein results in increased reduction of and results in decreased glutathionylation of Mefenamic Acid metabolite CTD PMID:29281794 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Mefenamic Acid results in increased activity of NR1I2 protein CTD PMID:28728110 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [pyrrolidine analog binds to Palladium binds to Mefenamic Acid] which results in decreased activity of PON1 protein; [pyrrolidine analog binds to Platinum binds to Mefenamic Acid] which results in decreased activity of PON1 protein CTD PMID:29512227 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Sell selectin L decreases expression ISO Mefenamic Acid results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Mefenamic Acid results in decreased activity of SLC22A1 protein CTD PMID:12388633 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity ISO Mefenamic Acid results in decreased activity of SLC22A9 protein CTD PMID:12388633 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Mefenamic Acid results in decreased activity of SLC22A6 protein CTD PMID:12388633 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity ISO Mefenamic Acid results in decreased activity of SLC22A7 protein CTD PMID:12388633 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein inhibits the reaction [CYP1A2 protein results in increased oxidation of Mefenamic Acid] CTD PMID:33259822 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
decreases activity		 ISO
EXP		 [Mefenamic Acid results in decreased activity of SULT1A1 protein] which results in decreased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of 6-hydroxymelatonin]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of Dopamine]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of harmol]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of naringenin]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of salicylamide] CTD PMID:11181495 PMID:29596660 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Tyr tyrosinase decreases expression ISO Mefenamic Acid results in decreased expression of TYR mRNA; Mefenamic Acid results in decreased expression of TYR protein CTD PMID:21079976 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Mefenamic Acid CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased metabolism of bromfenac] CTD PMID:19740398 PMID:31815452 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
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  CHEBI ontology 19812
    role 19784
      biological role 19782
        xenobiotic 18684
          mefenamic acid 35
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    subatomic particle 19810
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              atomic nucleus 19810
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                  main group element atom 19755
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                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic group 18902
                              organic divalent group 18884
                                organodiyl group 18884
                                  carbonyl group 18850
                                    carbonyl compound 18850
                                      carboxylic acid 18564
                                        aromatic carboxylic acid 11831
                                          benzoic acids 11806
                                            aminobenzoic acid 1637
                                              mefenamic acid 35
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