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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitroxoline
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Accession:CHEBI:67121 term browser browse the term
Definition:A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.
Synonyms:exact_synonym: 5-nitroquinolin-8-ol
 related_synonym: 5-NOK;   5-Nitro-8-hydroxyquinoline;   5-Nitro-8-oxyquinoline;   5-Nitro-8-quinolinol;   5-Nitrox;   5NOK;   8-Hydroxy-5-nitroquinoline;   Formula=C9H6N2O3;   InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H;   InChIKey=RJIWZDNTCBHXAL-UHFFFAOYSA-N;   SMILES=Oc1ccc([N+]([O-])=O)c2cccnc12;   nitroxolina;   nitroxolinum
 xref: CAS:4008-48-4;   Chemspider:13863774;   DrugBank:DB01422;   Drug_Central:1954;   KEGG:D07245
 xref_mesh: MESH:C005308
 xref: PDBeChem:HNQ;   PMID:1650428;   PMID:19530075;   PMID:20833114;   PMID:21088277;   PMID:21598397;   PMID:21899946;   PMID:22391578;   PMID:2571967;   PMID:3043342;   PMID:3302880;   PMID:3309833;   PMID:3543811;   PMID:6771105;   PMID:7251741;   Wikipedia:Nitroxoline



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nitroxoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:31638783 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT protein] CTD PMID:31638783 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of and affects the localization of FOXO3 protein]; nitroxoline results in decreased expression of and affects the localization of FOXO3 protein CTD PMID:31638783 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Metap2 methionyl aminopeptidase 2 decreases activity ISO nitroxoline results in decreased activity of METAP2 protein CTD PMID:21088277 NCBI chr 7:28,412,771...28,440,458
Ensembl chr 7:28,411,608...28,440,434
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]
nitroxoline results in decreased expression of SIRT1 protein
CTD PMID:31638783 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 protein] CTD PMID:31638783 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 protein] CTD PMID:31638783 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        antimicrobial agent 17482
          nitroxoline 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic heterocyclic compound 18604
                                  organonitrogen heterocyclic compound 17670
                                    quinolines 2592
                                      hydroxyquinoline 307
                                        monohydroxyquinoline 307
                                          nitroxoline 7
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