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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitroxoline
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Accession:CHEBI:67121 term browser browse the term
Definition:A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.
Synonyms:exact_synonym: 5-nitroquinolin-8-ol
 related_synonym: 5-NOK;   5-Nitro-8-hydroxyquinoline;   5-Nitro-8-oxyquinoline;   5-Nitro-8-quinolinol;   5-Nitrox;   5NOK;   8-Hydroxy-5-nitroquinoline;   Formula=C9H6N2O3;   InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H;   InChIKey=RJIWZDNTCBHXAL-UHFFFAOYSA-N;   SMILES=Oc1ccc([N+]([O-])=O)c2cccnc12;   nitroxolina;   nitroxolinum
 xref: CAS:4008-48-4;   Chemspider:13863774;   DrugBank:DB01422;   Drug_Central:1954;   KEGG:D07245
 xref_mesh: MESH:C005308
 xref: PDBeChem:HNQ;   PMID:1650428;   PMID:19530075;   PMID:20833114;   PMID:21088277;   PMID:21598397;   PMID:21899946;   PMID:22391578;   PMID:2571967;   PMID:3043342;   PMID:3302880;   PMID:3309833;   PMID:3543811;   PMID:6771105;   PMID:7251741;   Wikipedia:Nitroxoline



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nitroxoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:31638783 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT protein] CTD PMID:31638783 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of and affects the localization of FOXO3 protein]; nitroxoline results in decreased expression of and affects the localization of FOXO3 protein CTD PMID:31638783 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Metap2 methionyl aminopeptidase 2 decreases activity ISO nitroxoline results in decreased activity of METAP2 protein CTD PMID:21088277 NCBI chr 7:28,412,771...28,440,458
Ensembl chr 7:28,411,608...28,440,434
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]
nitroxoline results in decreased expression of SIRT1 protein
CTD PMID:31638783 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 protein] CTD PMID:31638783 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 protein] CTD PMID:31638783 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20083
    role 20034
      biological role 20033
        antimicrobial agent 17814
          nitroxoline 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20083
    subatomic particle 20081
      composite particle 20081
        hadron 20081
          baryon 20081
            nucleon 20081
              atomic nucleus 20081
                atom 20081
                  main group element atom 19982
                    p-block element atom 19982
                      carbon group element atom 19909
                        carbon atom 19902
                          organic molecular entity 19902
                            organic molecule 19849
                              organic cyclic compound 19604
                                organic heterocyclic compound 18824
                                  organonitrogen heterocyclic compound 17760
                                    quinolines 2618
                                      hydroxyquinoline 312
                                        monohydroxyquinoline 312
                                          nitroxoline 7
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