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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitroxoline
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Accession:CHEBI:67121 term browser browse the term
Definition:A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.
Synonyms:exact_synonym: 5-nitroquinolin-8-ol
 related_synonym: 5-NOK;   5-Nitro-8-hydroxyquinoline;   5-Nitro-8-oxyquinoline;   5-Nitro-8-quinolinol;   5-Nitrox;   5NOK;   8-Hydroxy-5-nitroquinoline;   Formula=C9H6N2O3;   InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H;   InChIKey=RJIWZDNTCBHXAL-UHFFFAOYSA-N;   SMILES=Oc1ccc([N+]([O-])=O)c2cccnc12;   nitroxolina;   nitroxolinum
 xref: CAS:4008-48-4;   Chemspider:13863774;   DrugBank:DB01422;   Drug_Central:1954;   KEGG:D07245
 xref_mesh: MESH:C005308
 xref: PDBeChem:HNQ;   PMID:1650428;   PMID:19530075;   PMID:20833114;   PMID:21088277;   PMID:21598397;   PMID:21899946;   PMID:22391578;   PMID:2571967;   PMID:3043342;   PMID:3302880;   PMID:3309833;   PMID:3543811;   PMID:6771105;   PMID:7251741;   Wikipedia:Nitroxoline


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nitroxoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:31638783 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cat catalase multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT protein] CTD PMID:31638783 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of and affects the localization of FOXO3 protein]; nitroxoline results in decreased expression of and affects the localization of FOXO3 protein CTD PMID:31638783 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Metap2 methionyl aminopeptidase 2 decreases activity ISO nitroxoline results in decreased activity of METAP2 protein CTD PMID:21088277 NCBI chr 7:34,762,241...34,789,456
Ensembl chr 7:34,762,231...34,789,479
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]
nitroxoline results in decreased expression of SIRT1 protein
CTD PMID:31638783 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 protein] CTD PMID:31638783 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 protein] CTD PMID:31638783 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          nitroxoline 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organonitrogen heterocyclic compound 17485
                                    quinolines 2563
                                      hydroxyquinoline 302
                                        monohydroxyquinoline 302
                                          nitroxoline 7
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