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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-nitro-1,2-phenylenediamine
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Accession:CHEBI:67116 term browser browse the term
Definition:The primary amino compound that is 1,2-phenylenediamine (o-phenylenediamine) substituted at the 4- (para-) position by a nitro group.
Synonyms:exact_synonym: 4-nitrobenzene-1,2-diamine
 related_synonym: 1,2-Diamino-4-nitrobenzene;   2-Amino-4-nitroaniline;   3,4-Diaminonitrobenzene;   4-Nitro-1,2-benzenediamine;   4-Nitro-1,2-diaminobenzene;   4-Nitro-o-phenylenediamine;   Formula=C6H7N3O2;   InChI=1S/C6H7N3O2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H,7-8H2;   InChIKey=RAUWPNXIALNKQM-UHFFFAOYSA-N;   SMILES=Nc1ccc(cc1N)[N+]([O-])=O;   p-nitro-o-phenylendiamine;   p-nitro-o-phenylenediamine
 xref: Beilstein:608106;   CAS:99-56-9;   KEGG:C19384
 xref_mesh: MESH:C012277
 xref: PMID:1650428;   PMID:2682235;   Patent:KR20080065716;   Reaxys:608106


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4-nitro-1,2-phenylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of ABCB1B mRNA CTD PMID:17070881 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of ACMSD mRNA CTD PMID:17070881 NCBI chr13:44,424,689...44,468,734
Ensembl chr13:44,424,689...44,468,734
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of ACSL3 mRNA CTD PMID:17070881 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
JBrowse link
G Aen apoptosis enhancing nuclease decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of AEN mRNA CTD PMID:17070881 NCBI chr 1:140,584,328...140,593,749
Ensembl chr 1:140,584,380...140,593,745
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO 1,2-diamino-4-nitrobenzene results in increased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO 1,2-diamino-4-nitrobenzene results in increased expression of AKR1C2 mRNA CTD PMID:26198647 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of AKR7A3 mRNA CTD PMID:17070881 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of ALDH1A1 mRNA CTD PMID:17070881 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of ALDH1A4 mRNA CTD PMID:17070881 NCBI chr 1:240,584,233...240,601,843
Ensembl chr 1:240,562,423...240,601,744
JBrowse link
G Apoa2 apolipoprotein A2 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of APOA2 mRNA CTD PMID:17070881 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of APOA4 mRNA CTD PMID:17070881 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of APOC3 mRNA CTD PMID:17070881 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Asf1a anti-silencing function 1A histone chaperone increases expression ISO 1,2-diamino-4-nitrobenzene results in increased expression of ASF1A mRNA CTD PMID:26198647 NCBI chr20:34,894,419...34,909,265
Ensembl chr20:34,894,419...34,909,265
JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of ATP6V1D mRNA CTD PMID:17070881 NCBI chr 6:102,032,271...102,047,754
Ensembl chr 6:102,032,276...102,047,758
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of BAX mRNA CTD PMID:17070881 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of BTG2 mRNA CTD PMID:17070881 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G C7 complement C7 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of C7 mRNA CTD PMID:17070881 NCBI chr 2:54,707,621...54,781,624
Ensembl chr 2:54,709,138...54,777,729
JBrowse link
G Cblc Cbl proto-oncogene C decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of CBLC mRNA CTD PMID:17070881 NCBI chr 1:80,699,321...80,716,146
Ensembl chr 1:80,699,323...80,716,146
JBrowse link
G Ccng1 cyclin G1 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of CCNG1 mRNA CTD PMID:17070881 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cd276 Cd276 molecule increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of CD276 mRNA CTD PMID:17070881 NCBI chr 8:63,312,060...63,350,411
Ensembl chr 8:63,318,019...63,350,269
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of CDKN1A mRNA CTD PMID:17070881 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cpq carboxypeptidase Q decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of CPQ mRNA CTD PMID:17070881 NCBI chr 7:71,709,174...72,167,413
Ensembl chr 7:71,709,157...72,167,417
JBrowse link
G Cryab crystallin, alpha B decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of CRYAB mRNA CTD PMID:17070881 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of CYP2C13 mRNA CTD PMID:17070881 NCBI chr 1:258,796,624...258,877,023
Ensembl chr 1:258,796,622...258,877,045
JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of CYP4F5 mRNA CTD PMID:17070881 NCBI chr 7:14,559,806...14,574,345
Ensembl chr 7:14,529,482...14,574,361
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of DDAH1 mRNA CTD PMID:17070881 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014
JBrowse link
G Epcam epithelial cell adhesion molecule increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of EPCAM mRNA CTD PMID:17070881 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of EPHX1 mRNA CTD PMID:17070881 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of FAS mRNA CTD PMID:17070881 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of FHIT mRNA CTD PMID:17070881 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO 1,2-diamino-4-nitrobenzene results in increased expression of GCLC mRNA CTD PMID:26198647 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 1,2-diamino-4-nitrobenzene results in increased expression of GCLM mRNA CTD PMID:26198647 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO 1,2-diamino-4-nitrobenzene results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of GRIA3 mRNA CTD PMID:17070881 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of GSTM1 mRNA CTD PMID:17070881 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of HSD17B6 mRNA CTD PMID:17070881 NCBI chr 7:2,412,370...2,431,249
Ensembl chr 7:2,412,363...2,431,197
Ensembl chr13:2,412,363...2,431,197
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of IL2RA mRNA CTD PMID:17070881 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO 1,2-diamino-4-nitrobenzene results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of MGMT mRNA CTD PMID:17070881 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of NUPR1 mRNA CTD PMID:17070881 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Olr37 olfactory receptor 37 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of OLR37 mRNA CTD PMID:17070881 NCBI chr 1:164,755,094...164,756,059 JBrowse link
G Orm1 orosomucoid 1 increases expression ISO 1,2-diamino-4-nitrobenzene results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of PHLDA3 mRNA CTD PMID:17070881 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of RHOBTB2 mRNA CTD PMID:17070881 NCBI chr15:51,465,148...51,485,562
Ensembl chr15:51,465,148...51,485,692
JBrowse link
G Serpina7 serpin family A member 7 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of SERPINA7 mRNA CTD PMID:17070881 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Slc16a10 solute carrier family 16 member 10 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of SLC16A10 mRNA CTD PMID:17070881 NCBI chr20:45,138,433...45,260,155
Ensembl chr20:45,143,453...45,260,119
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 1,2-diamino-4-nitrobenzene results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 decreases expression EXP 1,2-diamino-4-nitrobenzene results in decreased expression of SPINK1 mRNA CTD PMID:17070881 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO 1,2-diamino-4-nitrobenzene results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 1,2-diamino-4-nitrobenzene results in increased expression of SRXN1 mRNA CTD PMID:26198647 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of SUGCT mRNA CTD PMID:17070881 NCBI chr17:49,991,314...51,030,950 JBrowse link
G Sulf2 sulfatase 2 affects expression EXP 1,2-diamino-4-nitrobenzene affects the expression of SULF2 mRNA CTD PMID:17070881 NCBI chr 3:162,791,349...162,872,984
Ensembl chr 3:162,791,355...162,872,831
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of SULT2A1 mRNA CTD PMID:17070881 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression EXP 1,2-diamino-4-nitrobenzene results in increased expression of ZMAT3 mRNA CTD PMID:17070881 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      chemical role 19320
        environmental contaminant 18645
          benzene 5608
            1,2-phenylenediamine 2557
              4-nitro-1,2-phenylenediamine 54
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    main group molecular entity 19744
                      s-block molecular entity 19491
                        hydrogen molecular entity 19483
                          hydrides 18748
                            inorganic hydride 17481
                              pnictogen hydride 17454
                                nitrogen hydride 17296
                                  azane 17015
                                    ammonia 17014
                                      organic amino compound 17013
                                        polyamine 8238
                                          diamine 8165
                                            primary diamine 5645
                                              phenylenediamine 2641
                                                1,2-phenylenediamine 2557
                                                  4-nitro-1,2-phenylenediamine 54
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