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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:meclofenamic acid
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Accession:CHEBI:6710 term browser browse the term
Definition:An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
Synonyms:exact_synonym: 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid
 related_synonym: CI-583;   Formula=C14H11Cl2NO2;   INF 4668;   InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19);   InChIKey=SBDNJUWAMKYJOX-UHFFFAOYSA-N;   N-(2,6-dichloro-3-methylphenyl)anthranilic acid;   N-(2,6-dichloro-m-tolyl)anthranilic acid;   N-(3-methyl-2,6-dichlorophenyl)anthranilic acid;   SMILES=Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl;   acide meclofenamique;   acido meclofenamico;   acidum meclofenamicum
 xref: CAS:644-62-2;   DrugBank:DB00939;   Drug_Central:1650;   HMDB:HMDB0015074;   KEGG:C07117;   KEGG:D02341;   LINCS:LSM-3108
 xref_mesh: MESH:D008469
 xref: PDBeChem:JMS;   PMID:15598972;   PMID:16986603;   PMID:17348907;   PMID:1810521;   PMID:19279153;   PMID:21660425;   PMID:23534549;   PMID:23567745;   PMID:23584353;   PMID:322627;   PMID:7349327;   Patent:DE1149045;   Patent:US3313848;   Reaxys:2221428;   Wikipedia:Meclofenamic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:76230


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meclofenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Meclofenamic Acid results in decreased activity of AKR1C4 protein CTD PMID:27163852 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Meclofenamic Acid results in decreased activity of AKR1C2 protein CTD PMID:19010312 PMID:26362498 PMID:27163852 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Meclofenamic Acid results in decreased activity of AKR1C3 protein CTD PMID:19010312 PMID:26362498 PMID:27163852 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO Meclofenamic Acid results in decreased activity of ALOX5 protein CTD PMID:3020588 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Ren renin multiple interactions EXP Meclofenamic Acid inhibits the reaction [Yohimbine results in increased expression of REN protein] CTD PMID:6323192 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases activity ISO Meclofenamic Acid results in decreased activity of AKR1C1 protein CTD PMID:19010312 PMID:26362498 PMID:27163852 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
JBrowse link
G Sell selectin L decreases expression ISO Meclofenamic Acid results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO Meclofenamic Acid inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO Meclofenamic Acid results in decreased activity of SULT1A1 protein CTD PMID:17073578 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO Meclofenamic Acid results in decreased activity of SULT1E1 protein CTD PMID:17073578 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Meclofenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:10328874 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        pharmacological role 18842
          analgesic 13302
            meclofenamic acid 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        aromatic carboxylic acid 11708
                                          benzoic acids 11681
                                            aminobenzoic acid 1632
                                              meclofenamic acid 12
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