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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:meclofenamic acid
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Accession:CHEBI:6710 term browser browse the term
Definition:An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
Synonyms:exact_synonym: 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid
 related_synonym: CI-583;   Formula=C14H11Cl2NO2;   INF 4668;   InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19);   InChIKey=SBDNJUWAMKYJOX-UHFFFAOYSA-N;   N-(2,6-dichloro-3-methylphenyl)anthranilic acid;   N-(2,6-dichloro-m-tolyl)anthranilic acid;   N-(3-methyl-2,6-dichlorophenyl)anthranilic acid;   SMILES=Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl;   acide meclofenamique;   acido meclofenamico;   acidum meclofenamicum
 xref: CAS:644-62-2;   DrugBank:DB00939;   Drug_Central:1650;   HMDB:HMDB0015074;   KEGG:C07117;   KEGG:D02341;   LINCS:LSM-3108
 xref_mesh: MESH:D008469
 xref: PDBeChem:JMS;   PMID:15598972;   PMID:16986603;   PMID:17348907;   PMID:1810521;   PMID:19279153;   PMID:21660425;   PMID:23534549;   PMID:23567745;   PMID:23584353;   PMID:322627;   PMID:7349327;   Patent:DE1149045;   Patent:US3313848;   Reaxys:2221428;   Wikipedia:Meclofenamic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:76230


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meclofenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Meclofenamic Acid results in decreased activity of AKR1C4 protein CTD PMID:27163852 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Meclofenamic Acid results in decreased activity of AKR1C2 protein CTD PMID:19010312, PMID:26362498, PMID:27163852 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Meclofenamic Acid results in decreased activity of AKR1C3 protein CTD PMID:19010312, PMID:26362498, PMID:27163852 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO Meclofenamic Acid results in decreased activity of ALOX5 protein CTD PMID:3020588 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Ren renin multiple interactions EXP Meclofenamic Acid inhibits the reaction [Yohimbine results in increased expression of REN protein] CTD PMID:6323192 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Sell selectin L decreases expression ISO Meclofenamic Acid results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO Meclofenamic Acid inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO Meclofenamic Acid results in decreased activity of SULT1A1 protein CTD PMID:17073578 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO Meclofenamic Acid results in decreased activity of SULT1E1 protein CTD PMID:17073578 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Meclofenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:10328874 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        pharmacological role 18793
          analgesic 13061
            meclofenamic acid 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        aromatic carboxylic acid 10889
                                          benzoic acids 10858
                                            aminobenzoic acid 1614
                                              meclofenamic acid 11
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