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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Mazindol
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Accession:CHEBI:6702 term browser browse the term
Synonyms:related_synonym: Formula=C16H13ClN2O;   InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2;   InChIKey=ZPXSCAKFGYXMGA-UHFFFAOYSA-N;   SANOREX (TN);   SMILES=C1=CC=C2C(=C1)C=3N(C2(C=4C=CC(=CC4)Cl)O)CCN3;   mazanor;   mazildene
 xref: CAS:22232-71-9;   Drug_Central:1640;   HMDB:HMDB0014718;   KEGG:D00367
 xref_mesh: MESH:D008454


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Mazindol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO Mazindol inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium] CTD PMID:19647008 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO NOS1 protein affects the reaction [Methamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]] CTD PMID:11085313 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Slc18a2 solute carrier family 18 member A2 affects binding ISO Mazindol binds to SLC18A2 protein CTD PMID:7912402 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
affects binding
ISO
EXP
[Mazindol results in decreased activity of SLC6A3 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; Butyrates inhibits the reaction [Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]; Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Methamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]; NOS1 protein affects the reaction [Methamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]]
CTD PMID:9132989, PMID:11085313, PMID:11719704, PMID:15945060, PMID:17250655, PMID:17948891, PMID:18206288, PMID:25630971 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Mazindol binds to and results in decreased activity of SLC6A4 protein CTD PMID:16272152 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          carbon atom 19588
            organic molecular entity 19588
              Mazindol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            Mazindol 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.