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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sympatholytic agent
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Accession:CHEBI:66991 term browser browse the term
Definition:Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
Synonyms:related_synonym: sympatholytic;   sympatholytic agents;   sympatholytic drug;   sympatholytic drugs;   sympatholytics
 xref: Wikipedia:Sympatholytic


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alpha-methyl-L-dopa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase increases methylation
decreases activity
EXP COMT protein results in increased methylation of Methyldopa
Methyldopa results in decreased activity of COMT protein
CTD PMID:7053299 PMID:11160877 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 decreases activity EXP Methyldopa analog results in decreased activity of GSTA1 protein CTD PMID:8131222 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G GSTM1 glutathione S-transferase mu 1 decreases activity EXP Methyldopa analog results in decreased activity of GSTM1 protein CTD PMID:8131222 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases activity EXP Methyldopa analog results in decreased activity of GSTP1 protein CTD PMID:8131222 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G PRL prolactin increases expression
increases secretion
EXP Methyldopa results in increased expression of PRL protein
Methyldopa results in increased secretion of PRL protein
CTD PMID:1867878 PMID:7265421 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G REN renin decreases activity ISO Methyldopa results in decreased activity of REN protein CTD PMID:145319 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
alprenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions
increases phosphorylation
increases activity
EXP [Alprenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Alprenolol binds to and results in decreased activity of ADRB1 protein; Alprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; CGP 20712A affects the reaction [Alprenolol results in increased activity of ADRB1 protein]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[Alprenolol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein; Alprenolol results in increased phosphorylation of ADRB1 protein
CTD PMID:12761341 PMID:14730417 PMID:15060759 PMID:18787115 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP
ISO
[Alprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Alprenolol co-treated with ADRB2 protein] results in increased expression of GNAS protein; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
Alprenolol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; Alprenolol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]
CTD PMID:10455254 PMID:12198331 PMID:14730417 PMID:17925438 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G ADRB3 adrenoceptor beta 3 multiple interactions EXP [Alprenolol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Alprenolol binds to and results in increased activity of ADRB3 protein; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599
JBrowse link
G ARRB1 arrestin beta 1 multiple interactions EXP [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115 PMID:24334028 NCBI chr11:75,260,122...75,351,662
Ensembl chr11:75,260,122...75,351,705
JBrowse link
G ARRB2 arrestin beta 2 multiple interactions EXP Alprenolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115 NCBI chr17:4,710,619...4,721,500
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions
increases phosphorylation
EXP AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[Alprenolol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein
CTD PMID:18787115 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G GNAS GNAS complex locus multiple interactions EXP [Alprenolol co-treated with ADRB2 protein] results in increased expression of GNAS protein CTD PMID:10455254 NCBI chr20:58,839,681...58,911,192
Ensembl chr20:58,839,718...58,911,192
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 multiple interactions ISO Alprenolol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein] CTD PMID:12198331 NCBI chr11:67,266,420...67,286,556
Ensembl chr11:67,266,473...67,286,556
JBrowse link
G HBEGF heparin binding EGF like growth factor multiple interactions EXP HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]] CTD PMID:18787115 NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A multiple interactions ISO [Alprenolol co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] CTD PMID:8392199 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,550...46,897,076
Ensembl chr13:46,831,550...46,897,076
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
[Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK1 protein]
CTD PMID:17925438 PMID:18787115 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
[Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK3 protein]
CTD PMID:17925438 PMID:18787115 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MIR125A microRNA 125a multiple interactions
increases expression
EXP
ISO
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA
Alprenolol results in increased expression of MIR125A mRNA
CTD PMID:24334028 NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339
JBrowse link
G MIR125B1 microRNA 125b-1 multiple interactions
increases expression
EXP
ISO
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA
Alprenolol results in increased expression of MIR125B-1 mRNA
CTD PMID:24334028 NCBI chr11:122,099,757...122,099,844
Ensembl chr11:122,099,757...122,099,844
JBrowse link
G MIR150 microRNA 150 multiple interactions
increases expression
EXP
ISO
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA
Alprenolol results in increased expression of MIR150 mRNA
CTD PMID:24334028 NCBI chr19:49,500,785...49,500,868
Ensembl chr19:49,500,785...49,500,868
JBrowse link
G MIR214 microRNA 214 multiple interactions
increases expression
EXP
ISO
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA
Alprenolol results in increased expression of MIR214 mRNA
CTD PMID:24334028 NCBI chr 1:172,138,798...172,138,907
Ensembl chr 1:172,138,798...172,138,907
JBrowse link
G NPPA natriuretic peptide A increases expression ISO Alprenolol results in increased expression of NPPA mRNA CTD PMID:12721106 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G ODC1 ornithine decarboxylase 1 multiple interactions ISO Alprenolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein] CTD PMID:10353628 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G REN renin multiple interactions
decreases expression
EXP Alprenolol inhibits the reaction [Hydralazine results in increased expression of REN protein]
Alprenolol results in decreased expression of REN protein
CTD PMID:923630 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Alprenolol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
EXP Atenolol inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atenolol results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ADRA2A adrenoceptor alpha 2A affects response to substance EXP ADRA2A gene SNP affects the susceptibility to Atenolol CTD PMID:15614026 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907
JBrowse link
G ADRB1 adrenoceptor beta 1 decreases activity
multiple interactions
affects binding
affects response to substance
decreases expression
EXP
ISO
Atenolol results in decreased activity of ADRB1 protein
Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
Atenolol binds to ADRB1 protein
[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine; [Atenolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]
ADRB1 protein polymorphism affects the susceptibility to Atenolol
Atenolol results in decreased expression of ADRB1 mRNA
CTD PMID:1389726 PMID:2462161 PMID:2897299 PMID:8102213 PMID:8386603 PMID:9593075 PMID:10372227 PMID:10894789 PMID:11425575 PMID:11483288 PMID:12022239 PMID:12761341 PMID:14730417 PMID:15060759 PMID:17003101 PMID:17369603 PMID:17628611 PMID:22192668 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 increases expression
affects binding
multiple interactions
EXP
ISO
Atenolol results in increased expression of ADRB2 protein
Atenolol binds to ADRB2 protein
Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
[Atenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]
CTD PMID:2462161 PMID:6093157 PMID:9593075 PMID:11425575 PMID:11483288 PMID:12920204 PMID:14730417 PMID:17925438 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G ADRB3 adrenoceptor beta 3 multiple interactions EXP Atenolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599
JBrowse link
G AGT angiotensinogen affects response to substance
decreases expression
EXP AGT gene SNP affects the susceptibility to Atenolol
Atenolol results in decreased expression of AGT protein
CTD PMID:14639093 PMID:14700505 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AMY2B amylase alpha 2B multiple interactions ISO Atenolol inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Cisplatin results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Lithium Chloride results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 1:103,554,644...103,579,534
Ensembl chr 1:103,553,815...103,579,534
JBrowse link
G APOA1 apolipoprotein A1 decreases expression EXP Atenolol results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOA2 apolipoprotein A2 decreases expression EXP Atenolol results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631
JBrowse link
G APOB apolipoprotein B increases expression EXP Atenolol results in increased expression of APOB; Atenolol results in increased expression of APOB protein CTD PMID:1928808 PMID:2193493 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G ATF1 activating transcription factor 1 multiple interactions EXP Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein] CTD PMID:16671086 NCBI chr12:50,763,682...50,821,162
Ensembl chr12:50,763,710...50,821,162
JBrowse link
G B2M beta-2-microglobulin decreases expression EXP Atenolol results in decreased expression of B2M protein CTD PMID:2656332 NCBI chr15:44,711,492...44,718,145
Ensembl chr15:44,711,487...44,718,877
Ensembl chr15:44,711,487...44,718,877
JBrowse link
G BDKRB2 bradykinin receptor B2 affects response to substance EXP BDKRB2 exon polymorphism affects the susceptibility to Atenolol CTD PMID:12640257 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C increases response to substance EXP CACNA1C gene polymorphism results in increased susceptibility to Atenolol CTD PMID:20031608 NCBI chr12:1,969,552...2,697,950
Ensembl chr12:1,970,786...2,697,950
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein] CTD PMID:10728402 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase multiple interactions ISO Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Atenolol promotes the reaction [Quercetin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]]; Atenolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Quercetin promotes the reaction [Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]] CTD PMID:2575990 PMID:22391854 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions ISO Atenolol inhibits the reaction [Isoproterenol results in increased expression of CDK1 mRNA] CTD PMID:9593584 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CLEC2B C-type lectin domain family 2 member B increases expression EXP Atenolol results in increased expression of CLEC2B mRNA CTD PMID:19915711 NCBI chr12:9,852,369...9,869,354
Ensembl chr12:9,852,984...9,870,136
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein] CTD PMID:16671086 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G EDN1 endothelin 1 affects response to substance EXP EDN1 gene polymorphism affects the susceptibility to Atenolol CTD PMID:15188945 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of EGFR protein] CTD PMID:16671086 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G FAS Fas cell surface death receptor multiple interactions EXP Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand multiple interactions EXP Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B multiple interactions EXP Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 NCBI chr 2:24,033,205...24,067,743
Ensembl chr 2:24,049,701...24,063,681
JBrowse link
G FKBP5 FKBP prolyl isomerase 5 decreases expression EXP Atenolol results in decreased expression of FKBP5 mRNA CTD PMID:19915711 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO Atenolol inhibits the reaction [Dopamine results in increased activity of G6PD protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of G6PD protein] CTD PMID:1978808 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GJA1 gap junction protein alpha 1 increases expression ISO Atenolol results in increased expression of GJA1 protein CTD PMID:16448880 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GJA4 gap junction protein alpha 4 increases expression ISO Atenolol results in increased expression of GJA4 protein CTD PMID:16448880 NCBI chr 1:34,792,958...34,795,747
Ensembl chr 1:34,792,999...34,795,747
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 decreases expression ISO Atenolol results in decreased expression of GRK2 mRNA; Atenolol results in decreased expression of GRK2 protein CTD PMID:9788834 NCBI chr11:67,266,420...67,286,556
Ensembl chr11:67,266,473...67,286,556
JBrowse link
G INS insulin multiple interactions EXP Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 affects response to substance EXP KCNJ2 gene affects the susceptibility to Atenolol CTD PMID:15028050 NCBI chr17:70,169,532...70,180,044
Ensembl chr17:70,168,673...70,180,044
Ensembl chr17:70,168,673...70,180,044
JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 affects response to substance EXP KCNQ1 gene affects the susceptibility to Atenolol CTD PMID:15028050 NCBI chr11:2,445,008...2,849,110
Ensembl chr11:2,444,684...2,849,105
Ensembl chr11:2,444,684...2,849,105
JBrowse link
G LIPC lipase C, hepatic type multiple interactions EXP LIPC gene SNP affects the susceptibility to and affects the metabolism of Atenolol CTD PMID:23536766 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein] CTD PMID:16671086 PMID:17003101 PMID:17925438 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein] CTD PMID:16671086 PMID:17003101 PMID:17925438 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Atenolol inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:19439816 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPPA natriuretic peptide A decreases expression EXP Atenolol results in decreased expression of NPPA protein CTD PMID:12866806 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NPPB natriuretic peptide B multiple interactions
decreases expression
increases expression
ISO
EXP
[Atenolol co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA
Atenolol results in decreased expression of NPPB mRNA
Atenolol results in increased expression of NPPB protein
CTD PMID:15969258 PMID:18192850 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G PLA2G4C phospholipase A2 group IVC multiple interactions EXP PLA2G4C gene SNP affects the susceptibility to and affects the metabolism of Atenolol CTD PMID:23536766 NCBI chr19:48,047,846...48,111,383
Ensembl chr19:48,047,843...48,110,817
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein] CTD PMID:17003101 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTPN5 protein tyrosine phosphatase non-receptor type 5 multiple interactions ISO Atenolol inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] CTD PMID:17623046 NCBI chr11:18,727,928...18,792,721
Ensembl chr11:18,727,928...18,792,721
JBrowse link
G REN renin multiple interactions
decreases expression
decreases activity
EXP
ISO
[aliskiren co-treated with Atenolol] results in decreased activity of REN protein; [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein
Atenolol results in decreased expression of REN protein
Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]; Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]
Atenolol results in decreased activity of REN protein
CTD PMID:3142437 PMID:3333524 PMID:9300315 PMID:14639093 PMID:18957387 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G RYR2 ryanodine receptor 2 increases activity
multiple interactions
EXP Atenolol results in increased activity of RYR2 protein
Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein]
CTD PMID:12743001 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988
JBrowse link
G SLC19A1 solute carrier family 19 member 1 decreases expression EXP Atenolol results in decreased expression of SLC19A1 mRNA CTD PMID:19616087 NCBI chr21:45,502,517...45,563,140
Ensembl chr21:45,493,572...45,573,365
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Atenolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC6A8 solute carrier family 6 member 8 decreases expression EXP Atenolol results in decreased expression of SLC6A8 mRNA CTD PMID:19915711 NCBI chr  X:153,687,926...153,696,593
Ensembl chr  X:153,687,926...153,696,588
JBrowse link
G SLCO4C1 solute carrier organic anion transporter family member 4C1 increases expression EXP Atenolol results in increased expression of SLCO4C1 mRNA CTD PMID:19915711 NCBI chr 5:102,233,986...102,296,516
Ensembl chr 5:102,233,986...102,296,284
JBrowse link
G SNORA49 small nucleolar RNA, H/ACA box 49 increases expression EXP Atenolol results in increased expression of SNORA49 mRNA CTD PMID:19915711 NCBI chr12:132,031,224...132,031,360
Ensembl chr12:132,031,224...132,031,359
JBrowse link
G SNRPN small nuclear ribonucleoprotein polypeptide N increases expression EXP Atenolol results in increased expression of SNRPN mRNA CTD PMID:19915711 NCBI chr15:24,823,637...24,978,723
Ensembl chr15:24,823,637...24,978,723
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP
ISO
Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]
Atenolol promotes the reaction [Thyroxine results in decreased expression of SOD1 protein]
CTD PMID:2575990 PMID:11163531 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP
ISO
Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]
Atenolol inhibits the reaction [Thyroxine results in increased expression of SOD2 protein]
CTD PMID:2575990 PMID:11163531 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 decreases response to substance ISO TRPA1 gene mutant form results in decreased susceptibility to Atenolol CTD PMID:29627347 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TXN thioredoxin increases expression EXP Atenolol results in increased expression of TXN mRNA CTD PMID:19915711 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
betaxolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions
affects binding
ISO
EXP
Betaxolol affects the reaction [Cocaine affects the expression of ADRB1 protein]; Betaxolol inhibits the reaction [Cocaine affects the expression of ADRB1 protein]
Betaxolol binds to ADRB1 protein
Betaxolol binds to and results in decreased activity of ADRB1 protein
CTD PMID:10372227 PMID:11436944 PMID:17513029 PMID:18596687 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Betaxolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; Betaxolol binds to and results in decreased activity of ADRB2 protein CTD PMID:11436944 PMID:17925438 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO Betaxolol affects the reaction [Cocaine affects the phosphorylation of CREB1 protein] CTD PMID:18596687 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRH corticotropin releasing hormone multiple interactions ISO Betaxolol affects the reaction [Cocaine affects the expression of CRH mRNA] CTD PMID:18596687 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G NPPA natriuretic peptide A decreases expression ISO Betaxolol results in decreased expression of NPPA mRNA; Betaxolol results in decreased expression of NPPA protein CTD PMID:12693380 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NPPB natriuretic peptide B decreases expression ISO Betaxolol results in decreased expression of NPPB mRNA CTD PMID:12693380 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
bisoprolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases transport
multiple interactions
EXP ABCB1 protein results in increased transport of Bisoprolol
Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Bisoprolol]
CTD PMID:16671962 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ADRB1 adrenoceptor beta 1 decreases activity
increases expression
multiple interactions
affects binding
EXP
ISO
Bisoprolol results in decreased activity of ADRB1 protein
Bisoprolol results in increased expression of ADRB1 mRNA
[Bisoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; Bisoprolol binds to and results in decreased activity of ADRB1 protein; Bisoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Bisoprolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]
Bisoprolol binds to ADRB1 protein
CTD PMID:1389726 PMID:2897299 PMID:10372227 PMID:11562432 PMID:12535855 PMID:14730417 PMID:15060759 PMID:17200720 PMID:20668454 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions
increases expression
EXP
ISO
[Bisoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Bisoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Bisoprolol binds to and results in decreased activity of ADRB2 protein; Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
Bisoprolol results in increased expression of ADRB2 mRNA
CTD PMID:14730417 PMID:17925438 PMID:20668454 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G ADRB3 adrenoceptor beta 3 multiple interactions EXP Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599
JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases expression EXP Bisoprolol results in decreased expression of CCL2 protein CTD PMID:19840533 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G GNAS GNAS complex locus increases expression ISO Bisoprolol results in increased expression of GNAS mRNA CTD PMID:20668454 NCBI chr20:58,839,681...58,911,192
Ensembl chr20:58,839,718...58,911,192
JBrowse link
G IL10 interleukin 10 increases expression EXP Bisoprolol results in increased expression of IL10 protein CTD PMID:19840533 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta decreases expression EXP Bisoprolol results in decreased expression of IL1B protein CTD PMID:19840533 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 decreases expression EXP Bisoprolol results in decreased expression of IL6 protein CTD PMID:19840533 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin multiple interactions EXP Bisoprolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G PRKCA protein kinase C alpha decreases expression ISO Bisoprolol results in decreased expression of PRKCA protein CTD PMID:20668454 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PRKCD protein kinase C delta decreases expression ISO Bisoprolol results in decreased expression of PRKCD protein CTD PMID:20668454 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Bisoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Bisoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin] CTD PMID:19740083 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G TNF tumor necrosis factor decreases expression EXP Bisoprolol results in decreased expression of TNF protein CTD PMID:19840533 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
carteolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions EXP Carteolol binds to and results in decreased activity of ADRB1 protein CTD PMID:11436944 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP Carteolol binds to and results in decreased activity of ADRB2 protein CTD PMID:11436944 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
clonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor multiple interactions ISO [1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine CTD PMID:8987795 NCBI chr 1:203,127,705...203,167,405
Ensembl chr 1:203,090,654...203,167,405
JBrowse link
G ADRA2A adrenoceptor alpha 2A multiple interactions EXP
ISO
Clonidine binds to and results in increased activity of ADRA2A protein
[5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine
CTD PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907
JBrowse link
G ADRA2B adrenoceptor alpha 2B multiple interactions EXP Clonidine binds to and results in increased activity of ADRA2B protein CTD PMID:10217548 NCBI chr 2:96,112,876...96,116,571
Ensembl chr 2:96,112,876...96,116,571
JBrowse link
G ADRA2C adrenoceptor alpha 2C multiple interactions
increases response to substance
EXP
ISO
Clonidine binds to and results in increased activity of ADRA2C protein
ADRA2C results in increased susceptibility to Clonidine
CTD PMID:8987795 PMID:10217548 NCBI chr 4:3,766,385...3,768,526
Ensembl chr 4:3,766,348...3,768,526
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 increases expression EXP Clonidine results in increased expression of AIFM1 protein CTD PMID:28115640 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G APOA1 apolipoprotein A1 decreases expression EXP Clonidine results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOA2 apolipoprotein A2 decreases expression EXP Clonidine results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631
JBrowse link
G AVP arginine vasopressin increases expression ISO Clonidine results in increased expression of AVP protein CTD PMID:7400963 NCBI chr20:3,082,556...3,093,521
Ensembl chr20:3,082,556...3,084,724
JBrowse link
G BAD BCL2 associated agonist of cell death increases expression EXP Clonidine results in increased expression of BAD protein CTD PMID:28115640 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Clonidine results in decreased expression of BCL2 protein CTD PMID:28115640 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 increases expression ISO Clonidine results in increased expression of BCL2L1 mRNA CTD PMID:12423672 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CASP2 caspase 2 increases activity EXP Clonidine results in increased activity of CASP2 protein CTD PMID:28115640 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
JBrowse link
G CASP3 caspase 3 increases expression
increases activity
ISO
EXP
Clonidine results in increased expression of CASP3 mRNA
Clonidine results in increased activity of CASP3 protein
CTD PMID:15351510 PMID:28115640 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases activity EXP Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases activity EXP Clonidine results in increased activity of CASP9 protein CTD PMID:28115640 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions ISO Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides] CTD PMID:12598592 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G COMT catechol-O-methyltransferase increases expression ISO Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 increases metabolic processing
multiple interactions
EXP CYP2D6 protein results in increased metabolism of Clonidine
[[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine
CTD PMID:31585114 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein] CTD PMID:12560108 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GAL galanin and GMAP prepropeptide increases activity ISO Clonidine results in increased activity of GAL protein CTD PMID:10818254 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
JBrowse link
G GH1 growth hormone 1 increases expression
multiple interactions
increases secretion
EXP
ISO
Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]
L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]
CTD PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 PMID:17889730 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G GNAI1 G protein subunit alpha i1 affects response to substance ISO GNAI1 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 7:80,134,831...80,226,181
Ensembl chr 7:79,768,028...80,226,181
JBrowse link
G GNAI3 G protein subunit alpha i3 affects response to substance ISO GNAI3 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 increases expression ISO Clonidine results in increased expression of HSP90AA1 mRNA CTD PMID:10684495 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression ISO Clonidine results in increased expression of HSPD1 mRNA CTD PMID:10684495 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G IFNG interferon gamma multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein] CTD PMID:16192389 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 increases secretion EXP Clonidine results in increased secretion of IL10 protein CTD PMID:16612254 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein] CTD PMID:16192389 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]
CTD PMID:12065299 PMID:16192389 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein] CTD PMID:16192389 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G INS insulin decreases secretion EXP Clonidine results in decreased secretion of INS protein CTD PMID:707001 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NPPA natriuretic peptide A increases expression ISO Clonidine results in increased expression of NPPA protein CTD PMID:18378355 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NPY neuropeptide Y increases expression
multiple interactions
decreases expression
ISO Clonidine results in increased expression of NPY mRNA
Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]
CTD PMID:1878751 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
JBrowse link
G OPRM1 opioid receptor mu 1 multiple interactions
increases response to substance
ISO [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine
OPRM1 results in increased susceptibility to Clonidine
CTD PMID:8987795 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
JBrowse link
G PDCD4 programmed cell death 4 decreases expression EXP Clonidine results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G POMC proopiomelanocortin increases expression
multiple interactions
increases secretion
decreases expression
EXP
ISO
Clonidine results in increased expression of POMC protein
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]
Clonidine results in decreased expression of POMC protein
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone
CTD PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PRL prolactin increases expression
multiple interactions
EXP
ISO
Clonidine results in increased expression of PRL protein
Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]
CTD PMID:1678730 PMID:16401171 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G REN renin increases activity
decreases activity
decreases expression
multiple interactions
EXP Clonidine results in increased activity of REN protein
Clonidine results in decreased activity of REN protein
Clonidine results in decreased expression of REN protein
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
CTD PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 PMID:7837211 PMID:12014310 PMID:20833658 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091 PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC22A3 solute carrier family 22 member 3 multiple interactions EXP
ISO
Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:9830022 PMID:10966924 PMID:16263091 NCBI chr 6:160,348,378...160,454,982
Ensembl chr 6:160,348,378...160,452,577
JBrowse link
G SLC47A1 solute carrier family 47 member 1 multiple interactions EXP Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034
JBrowse link
G SLC47A2 solute carrier family 47 member 2 multiple interactions EXP Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,678,313...19,719,598
Ensembl chr17:19,678,288...19,718,979
JBrowse link
G TAAR1 trace amine associated receptor 1 increases activity
multiple interactions
ISO Clonidine results in increased activity of TAAR1 protein
[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 6:132,643,312...132,659,182
Ensembl chr 6:132,644,898...132,646,051
Ensembl chr 6:132,644,898...132,646,051
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein CTD PMID:19067675 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein] CTD PMID:16192389 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 increases expression EXP Clonidine results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G TPD52 tumor protein D52 increases expression EXP Clonidine results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 8:79,918,717...80,171,564
Ensembl chr 8:80,034,745...80,231,232
JBrowse link
clonidine (amino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor multiple interactions ISO [1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine CTD PMID:8987795 NCBI chr 1:203,127,705...203,167,405
Ensembl chr 1:203,090,654...203,167,405
JBrowse link
G ADRA2A adrenoceptor alpha 2A multiple interactions EXP
ISO
Clonidine binds to and results in increased activity of ADRA2A protein
[5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine
CTD PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907
JBrowse link
G ADRA2B adrenoceptor alpha 2B multiple interactions EXP Clonidine binds to and results in increased activity of ADRA2B protein CTD PMID:10217548 NCBI chr 2:96,112,876...96,116,571
Ensembl chr 2:96,112,876...96,116,571
JBrowse link
G ADRA2C adrenoceptor alpha 2C multiple interactions
increases response to substance
EXP
ISO
Clonidine binds to and results in increased activity of ADRA2C protein
ADRA2C results in increased susceptibility to Clonidine
CTD PMID:8987795 PMID:10217548 NCBI chr 4:3,766,385...3,768,526
Ensembl chr 4:3,766,348...3,768,526
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 increases expression EXP Clonidine results in increased expression of AIFM1 protein CTD PMID:28115640 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G APOA1 apolipoprotein A1 decreases expression EXP Clonidine results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOA2 apolipoprotein A2 decreases expression EXP Clonidine results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631
JBrowse link
G AVP arginine vasopressin increases expression ISO Clonidine results in increased expression of AVP protein CTD PMID:7400963 NCBI chr20:3,082,556...3,093,521
Ensembl chr20:3,082,556...3,084,724
JBrowse link
G BAD BCL2 associated agonist of cell death increases expression EXP Clonidine results in increased expression of BAD protein CTD PMID:28115640 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Clonidine results in decreased expression of BCL2 protein CTD PMID:28115640 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 increases expression ISO Clonidine results in increased expression of BCL2L1 mRNA CTD PMID:12423672 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CASP2 caspase 2 increases activity EXP Clonidine results in increased activity of CASP2 protein CTD PMID:28115640 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
JBrowse link
G CASP3 caspase 3 increases expression
increases activity
ISO
EXP
Clonidine results in increased expression of CASP3 mRNA
Clonidine results in increased activity of CASP3 protein
CTD PMID:15351510 PMID:28115640 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases activity EXP Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases activity EXP Clonidine results in increased activity of CASP9 protein CTD PMID:28115640 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions ISO Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides] CTD PMID:12598592 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G COMT catechol-O-methyltransferase increases expression ISO Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 increases metabolic processing
multiple interactions
EXP CYP2D6 protein results in increased metabolism of Clonidine
[[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine
CTD PMID:31585114 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein] CTD PMID:12560108 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GAL galanin and GMAP prepropeptide increases activity ISO Clonidine results in increased activity of GAL protein CTD PMID:10818254 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
JBrowse link
G GH1 growth hormone 1 increases expression
multiple interactions
increases secretion
EXP
ISO
Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]
L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]
CTD PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 PMID:17889730 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G GNAI1 G protein subunit alpha i1 affects response to substance ISO GNAI1 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 7:80,134,831...80,226,181
Ensembl chr 7:79,768,028...80,226,181
JBrowse link
G GNAI3 G protein subunit alpha i3 affects response to substance ISO GNAI3 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 increases expression ISO Clonidine results in increased expression of HSP90AA1 mRNA CTD PMID:10684495 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression ISO Clonidine results in increased expression of HSPD1 mRNA CTD PMID:10684495 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G IFNG interferon gamma multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein] CTD PMID:16192389 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 increases secretion EXP Clonidine results in increased secretion of IL10 protein CTD PMID:16612254 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein] CTD PMID:16192389 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]
CTD PMID:12065299 PMID:16192389 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein] CTD PMID:16192389 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G INS insulin decreases secretion EXP Clonidine results in decreased secretion of INS protein CTD PMID:707001 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NPPA natriuretic peptide A increases expression ISO Clonidine results in increased expression of NPPA protein CTD PMID:18378355 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NPY neuropeptide Y increases expression
multiple interactions
decreases expression
ISO Clonidine results in increased expression of NPY mRNA
Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]
CTD PMID:1878751 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
JBrowse link
G OPRM1 opioid receptor mu 1 multiple interactions
increases response to substance
ISO [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine
OPRM1 results in increased susceptibility to Clonidine
CTD PMID:8987795 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
JBrowse link
G PDCD4 programmed cell death 4 decreases expression EXP Clonidine results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G POMC proopiomelanocortin increases expression
multiple interactions
increases secretion
decreases expression
EXP
ISO
Clonidine results in increased expression of POMC protein
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]
Clonidine results in decreased expression of POMC protein
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone
CTD PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PRL prolactin increases expression
multiple interactions
EXP
ISO
Clonidine results in increased expression of PRL protein
Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]
CTD PMID:1678730 PMID:16401171 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G REN renin increases activity
decreases activity
decreases expression
multiple interactions
EXP Clonidine results in increased activity of REN protein
Clonidine results in decreased activity of REN protein
Clonidine results in decreased expression of REN protein
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
CTD PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 PMID:7837211 PMID:12014310 PMID:20833658 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091 PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC22A3 solute carrier family 22 member 3 multiple interactions EXP
ISO
Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
CTD PMID:9830022 PMID:10966924 PMID:16263091 NCBI chr 6:160,348,378...160,454,982
Ensembl chr 6:160,348,378...160,452,577
JBrowse link
G SLC47A1 solute carrier family 47 member 1 multiple interactions EXP Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034
JBrowse link
G SLC47A2 solute carrier family 47 member 2 multiple interactions EXP Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,678,313...19,719,598
Ensembl chr17:19,678,288...19,718,979
JBrowse link
G TAAR1 trace amine associated receptor 1 increases activity
multiple interactions
ISO Clonidine results in increased activity of TAAR1 protein
[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 6:132,643,312...132,659,182
Ensembl chr 6:132,644,898...132,646,051
Ensembl chr 6:132,644,898...132,646,051
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein CTD PMID:19067675 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein] CTD PMID:16192389 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 increases expression EXP Clonidine results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G TPD52 tumor protein D52 increases expression EXP Clonidine results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 8:79,918,717...80,171,564
Ensembl chr 8:80,034,745...80,231,232
JBrowse link
clonidine (imino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor multiple interactions ISO [1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine CTD PMID:8987795 NCBI chr 1:203,127,705...203,167,405
Ensembl chr 1:203,090,654...203,167,405
JBrowse link
G ADRA2A adrenoceptor alpha 2A multiple interactions EXP
ISO
Clonidine binds to and results in increased activity of ADRA2A protein
[5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine
CTD PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907
JBrowse link
G ADRA2B adrenoceptor alpha 2B multiple interactions EXP Clonidine binds to and results in increased activity of ADRA2B protein CTD PMID:10217548 NCBI chr 2:96,112,876...96,116,571
Ensembl chr 2:96,112,876...96,116,571
JBrowse link
G ADRA2C adrenoceptor alpha 2C multiple interactions
increases response to substance
EXP
ISO
Clonidine binds to and results in increased activity of ADRA2C protein
ADRA2C results in increased susceptibility to Clonidine
CTD PMID:8987795 PMID:10217548 NCBI chr 4:3,766,385...3,768,526
Ensembl chr 4:3,766,348...3,768,526
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 increases expression EXP Clonidine results in increased expression of AIFM1 protein CTD PMID:28115640 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G APOA1 apolipoprotein A1 decreases expression EXP Clonidine results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOA2 apolipoprotein A2 decreases expression EXP Clonidine results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631
JBrowse link
G AVP arginine vasopressin increases expression ISO Clonidine results in increased expression of AVP protein CTD PMID:7400963 NCBI chr20:3,082,556...3,093,521
Ensembl chr20:3,082,556...3,084,724
JBrowse link
G BAD BCL2 associated agonist of cell death increases expression EXP Clonidine results in increased expression of BAD protein CTD PMID:28115640 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Clonidine results in decreased expression of BCL2 protein CTD PMID:28115640 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 increases expression ISO Clonidine results in increased expression of BCL2L1 mRNA CTD PMID:12423672 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CASP2 caspase 2 increases activity EXP Clonidine results in increased activity of CASP2 protein CTD PMID:28115640 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
JBrowse link
G CASP3 caspase 3 increases expression
increases activity
ISO
EXP
Clonidine results in increased expression of CASP3 mRNA
Clonidine results in increased activity of CASP3 protein
CTD PMID:15351510 PMID:28115640 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases activity EXP Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases activity EXP Clonidine results in increased activity of CASP9 protein CTD PMID:28115640 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions ISO Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides] CTD PMID:12598592 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G COMT catechol-O-methyltransferase increases expression ISO Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 increases metabolic processing
multiple interactions
EXP CYP2D6 protein results in increased metabolism of Clonidine
[[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine
CTD PMID:31585114 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein] CTD PMID:12560108 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GAL galanin and GMAP prepropeptide increases activity ISO Clonidine results in increased activity of GAL protein CTD PMID:10818254 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
JBrowse link
G GH1 growth hormone 1 increases expression
multiple interactions
increases secretion
EXP
ISO
Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]
L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]
CTD PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 PMID:17889730 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G GNAI1 G protein subunit alpha i1 affects response to substance ISO GNAI1 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 7:80,134,831...80,226,181
Ensembl chr 7:79,768,028...80,226,181
JBrowse link
G GNAI3 G protein subunit alpha i3 affects response to substance ISO GNAI3 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 increases expression ISO Clonidine results in increased expression of HSP90AA1 mRNA CTD PMID:10684495 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression ISO Clonidine results in increased expression of HSPD1 mRNA CTD PMID:10684495 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G IFNG interferon gamma multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein] CTD PMID:16192389 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 increases secretion EXP Clonidine results in increased secretion of IL10 protein CTD PMID:16612254 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein] CTD PMID:16192389 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]
CTD PMID:12065299 PMID:16192389 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein] CTD PMID:16192389 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G INS insulin decreases secretion EXP Clonidine results in decreased secretion of INS protein CTD PMID:707001 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NPPA natriuretic peptide A increases expression ISO Clonidine results in increased expression of NPPA protein CTD PMID:18378355 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NPY neuropeptide Y increases expression
multiple interactions
decreases expression
ISO Clonidine results in increased expression of NPY mRNA
Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]
CTD PMID:1878751 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
JBrowse link
G OPRM1 opioid receptor mu 1 multiple interactions
increases response to substance
ISO [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine
OPRM1 results in increased susceptibility to Clonidine
CTD PMID:8987795 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
JBrowse link
G PDCD4 programmed cell death 4 decreases expression EXP Clonidine results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G POMC proopiomelanocortin increases expression
multiple interactions
increases secretion
decreases expression
EXP
ISO
Clonidine results in increased expression of POMC protein
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]
Clonidine results in decreased expression of POMC protein
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone
CTD PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PRL prolactin increases expression
multiple interactions
EXP
ISO
Clonidine results in increased expression of PRL protein
Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]
CTD PMID:1678730 PMID:16401171 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G REN renin increases activity
decreases activity
decreases expression
multiple interactions
EXP Clonidine results in increased activity of REN protein
Clonidine results in decreased activity of REN protein
Clonidine results in decreased expression of REN protein
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
CTD PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 PMID:7837211 PMID:12014310 PMID:20833658 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091 PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC22A3 solute carrier family 22 member 3 multiple interactions EXP
ISO
Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
CTD PMID:9830022 PMID:10966924 PMID:16263091 NCBI chr 6:160,348,378...160,454,982
Ensembl chr 6:160,348,378...160,452,577
JBrowse link
G SLC47A1 solute carrier family 47 member 1 multiple interactions EXP Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034
JBrowse link
G SLC47A2 solute carrier family 47 member 2 multiple interactions EXP Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,678,313...19,719,598
Ensembl chr17:19,678,288...19,718,979
JBrowse link
G TAAR1 trace amine associated receptor 1 increases activity
multiple interactions
ISO Clonidine results in increased activity of TAAR1 protein
[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 6:132,643,312...132,659,182
Ensembl chr 6:132,644,898...132,646,051
Ensembl chr 6:132,644,898...132,646,051
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein CTD PMID:19067675 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein] CTD PMID:16192389 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 increases expression EXP Clonidine results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G TPD52 tumor protein D52 increases expression EXP Clonidine results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 8:79,918,717...80,171,564
Ensembl chr 8:80,034,745...80,231,232
JBrowse link
debrisoquin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases response to substance
increases metabolic processing
increases hydroxylation
affects metabolic processing
increases abundance
multiple interactions
decreases metabolic processing
EXP CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin
CYP2D6 protein results in increased metabolism of Debrisoquin
CYP2D6 protein results in increased hydroxylation of Debrisoquin
CYP2D6 protein affects the metabolism of Debrisoquin; CYP2D6 protein polymorphism affects the metabolism of Debrisoquin
CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite
CYP2D6 gene mutant form affects the metabolism of and affects the hydroxylation of Debrisoquin; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite]
CYP2D6 gene mutant form results in decreased metabolism of Debrisoquin; CYP2D6 gene polymorphism results in decreased metabolism of Debrisoquin
CTD PMID:3577206 PMID:6603386 PMID:8946814 PMID:11673748 PMID:11823760 PMID:12464242 PMID:17470523 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
dihydroergotamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity EXP Dihydroergotamine results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 decreases activity EXP Dihydroergotamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
increases activity
EXP
ISO
Dihydroergotamine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Dihydroergotamine results in decreased activity of CYP1A1 protein
Dihydroergotamine results in increased activity of CYP1A1 protein
CTD PMID:18420780 PMID:18493746 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity ISO Dihydroergotamine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2A7 cytochrome P450 family 2 subfamily A member 7 decreases activity ISO Dihydroergotamine results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr19:40,875,439...40,885,951
Ensembl chr19:40,875,439...40,882,752
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 decreases activity ISO Dihydroergotamine results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases activity ISO Dihydroergotamine results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP Dihydroergotamine results in decreased activity of CYP2C9 protein CTD PMID:18420780 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases activity EXP
ISO
Dihydroergotamine results in decreased activity of CYP2D6 protein
Dihydroergotamine results in decreased activity of CYP2D22 protein
CTD PMID:18420780 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP
ISO
Dihydroergotamine results in decreased activity of CYP3A4 protein
Dihydroergotamine results in decreased activity of CYP3A11 protein
CTD PMID:18420780 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Dihydroergotamine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
guanethidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 decreases activity EXP Guanethidine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant affects expression
increases expression
ISO Guanethidine affects the expression of ACP5 protein
Guanethidine results in increased expression of ACP5 mRNA
CTD PMID:14527964 NCBI chr19:11,574,660...11,578,983
Ensembl chr19:11,574,660...11,579,008
JBrowse link
G CTSK cathepsin K increases expression
affects expression
ISO Guanethidine results in increased expression of CTSK mRNA
Guanethidine affects the expression of CTSK protein
CTD PMID:14527964 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,796,208...150,808,260
Ensembl chr 1:150,796,208...150,808,260
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO Guanethidine inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein] CTD PMID:16510159 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G MMP13 matrix metallopeptidase 13 increases expression ISO Guanethidine results in increased expression of MMP13 mRNA CTD PMID:14527964 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G NPY neuropeptide Y decreases expression
decreases secretion
ISO
EXP
Guanethidine results in decreased expression of NPY protein
Guanethidine results in decreased secretion of NPY protein
CTD PMID:9460767 PMID:14527964 PMID:15003356 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions ISO Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA] CTD PMID:15850565 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G TH tyrosine hydroxylase decreases expression ISO Guanethidine results in decreased expression of TH protein CTD PMID:9460767 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G VIP vasoactive intestinal peptide decreases expression ISO Guanethidine results in decreased expression of VIP protein CTD PMID:14527964 NCBI chr 6:152,750,797...152,759,765
Ensembl chr 6:152,750,797...152,759,765
JBrowse link
labetalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 decreases activity EXP Labetalol results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G ACE2 angiotensin I converting enzyme 2 increases activity EXP Labetalol results in increased activity of ACE2 protein CTD PMID:21859683 NCBI chr  X:15,518,197...15,602,158
Ensembl chr  X:15,561,033...15,602,148
Ensembl chr  X:15,561,033...15,602,148
JBrowse link
G ADRB1 adrenoceptor beta 1 decreases activity
affects binding
increases activity
multiple interactions
EXP
ISO
Labetalol results in decreased activity of ADRB1 protein
Labetalol binds to ADRB1 protein
Labetalol results in increased activity of ADRB1 protein
[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP; CGP 20712A inhibits the reaction [[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [Labetalol results in increased activity of ADRB1 protein]
Labetalol binds to and results in decreased activity of ADRB1 protein; Labetalol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
CTD PMID:2462161 PMID:2567112 PMID:11425575 PMID:11483288 PMID:12761341 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 decreases activity
affects binding
multiple interactions
EXP
ISO
Labetalol results in decreased activity of ADRB2 protein
Labetalol binds to ADRB2 protein
[Labetalol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein
Labetalol binds to and results in decreased activity of ADRB2 protein; Labetalol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
CTD PMID:2462161 PMID:2567112 PMID:11425575 PMID:11483288 PMID:17925438 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G AGT angiotensinogen decreases expression EXP Labetalol results in decreased expression of AGT protein CTD PMID:14627 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AVP arginine vasopressin multiple interactions EXP [Labetalol co-treated with Isoflurane] results in increased expression of AVP protein CTD PMID:1897344 NCBI chr20:3,082,556...3,093,521
Ensembl chr20:3,082,556...3,084,724
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP [Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP [Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NPPA natriuretic peptide A decreases activity EXP Labetalol results in decreased activity of NPPA protein CTD PMID:2524958 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G PRL prolactin multiple interactions
increases expression
EXP carbidopa, levodopa drug combination inhibits the reaction [Labetalol results in increased expression of PRL protein] CTD PMID:7105431 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G REN renin multiple interactions
decreases activity
EXP [Labetalol co-treated with Isoflurane] results in increased expression of REN protein
Labetalol results in decreased activity of REN protein
CTD PMID:1897344 PMID:2524958 PMID:7013770 PMID:7988622 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A1 protein] results in increased glucuronidation of Labetalol CTD PMID:18098064 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 multiple interactions EXP [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol; Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol] CTD PMID:18098064 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987
JBrowse link
methysergide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 decreases activity EXP Methysergide results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G ADRA1A adrenoceptor alpha 1A multiple interactions ISO Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:16545797 NCBI chr 8:26,738,113...26,870,994
Ensembl chr 8:26,748,150...26,867,278
JBrowse link
G CALCA calcitonin related polypeptide alpha affects activity ISO Methysergide affects the activity of CALCA protein CTD PMID:10075105 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B affects binding ISO Methysergide binds to HTR1B protein CTD PMID:11888550 NCBI chr 6:77,460,924...77,463,491
Ensembl chr 6:77,461,753...77,463,773
Ensembl chr 6:77,461,753...77,463,773
JBrowse link
nadolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions EXP Nadolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:15060759 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Nadolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP CTD PMID:17925438 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G IL10 interleukin 10 multiple interactions ISO [Nadolol co-treated with Mifepristone] promotes the reaction [methyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]] CTD PMID:16321413 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12B interleukin 12B multiple interactions ISO [Nadolol co-treated with Mifepristone] inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] CTD PMID:16321413 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Nadolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24371
    role 24282
      biological role 24249
        pharmacological role 21140
          neurotransmitter agent 18691
            adrenergic agent 9175
              sympatholytic agent 137
                alpha-methyl-L-dopa + 6
                alprenolol + 20
                atenolol + 53
                betaxolol + 6
                bisoprolol + 15
                carteolol 2
                clonidine + 52
                debrisoquin + 1
                dihydroergotamine + 11
                ergoloid mesylate 0
                guanethidine + 9
                labetalol 13
                methysergide 4
                nadolol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 24371
    role 24282
      application 23779
        pharmaceutical 23340
          drug 23340
            neurotransmitter agent 18691
              adrenergic agent 9175
                sympatholytic agent 137
                  alpha-methyl-L-dopa + 6
                  alprenolol + 20
                  atenolol + 53
                  betaxolol + 6
                  bisoprolol + 15
                  carteolol 2
                  clonidine + 52
                  debrisoquin + 1
                  dihydroergotamine + 11
                  ergoloid mesylate 0
                  guanethidine + 9
                  labetalol 13
                  methysergide 4
                  nadolol 5
paths to the root