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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sympatholytic agent
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Accession:CHEBI:66991 term browser browse the term
Definition:Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
Synonyms:related_synonym: sympatholytic;   sympatholytic agents;   sympatholytic drug;   sympatholytic drugs;   sympatholytics
 xref: Wikipedia:Sympatholytic


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atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
clonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases response to substance
EXP Clonidine binds to and results in increased activity of ADRA2A protein
ADRA2A protein results in increased susceptibility to Clonidine
CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684
JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722
JBrowse link
G NISCH nischarin multiple interactions
affects binding
EXP Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein] CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity
EXP [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
JBrowse link
G REN renin multiple interactions
decreases activity
EXP Clonidine results in decreased secretion of and results in decreased activity of REN protein
Clonidine results in decreased activity of REN protein
CTD PMID:6248808 PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
clonidine (amino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases response to substance
EXP Clonidine binds to and results in increased activity of ADRA2A protein
ADRA2A protein results in increased susceptibility to Clonidine
CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684
JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722
JBrowse link
G NISCH nischarin affects binding
multiple interactions
EXP Clonidine binds to NISCH protein
Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]
CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma increases activity
multiple interactions
EXP Clonidine results in increased activity of PIK3CG protein
[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein]
CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
JBrowse link
G REN renin multiple interactions
decreases activity
EXP Clonidine results in decreased secretion of and results in decreased activity of REN protein
Clonidine results in decreased activity of REN protein
CTD PMID:6248808 PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
clonidine (imino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases response to substance
EXP Clonidine binds to and results in increased activity of ADRA2A protein
ADRA2A protein results in increased susceptibility to Clonidine
CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684
JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722
JBrowse link
G NISCH nischarin affects binding
multiple interactions
EXP Clonidine binds to NISCH protein
Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]
CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity
EXP [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
JBrowse link
G REN renin multiple interactions
decreases activity
EXP Clonidine results in decreased secretion of and results in decreased activity of REN protein
Clonidine results in decreased activity of REN protein
CTD PMID:6248808 PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 226
    role 226
      biological role 226
        pharmacological role 147
          neurotransmitter agent 88
            adrenergic agent 27
              sympatholytic agent 6
                alpha-methyl-L-dopa + 0
                alprenolol + 0
                atenolol + 1
                betaxolol + 0
                bisoprolol + 0
                carteolol 0
                clonidine + 6
                debrisoquin + 0
                dihydroergotamine + 0
                ergoloid mesylate 0
                guanethidine + 0
                labetalol 0
                methysergide 0
                nadolol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 226
    role 226
      application 193
        pharmaceutical 190
          drug 190
            neurotransmitter agent 88
              adrenergic agent 27
                sympatholytic agent 6
                  alpha-methyl-L-dopa + 0
                  alprenolol + 0
                  atenolol + 1
                  betaxolol + 0
                  bisoprolol + 0
                  carteolol 0
                  clonidine + 6
                  debrisoquin + 0
                  dihydroergotamine + 0
                  ergoloid mesylate 0
                  guanethidine + 0
                  labetalol 0
                  methysergide 0
                  nadolol 0
paths to the root