antidyskinesia agent - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	antidyskinesia agent	go back to main search page
Accession:	CHEBI:66956	browse the term
Definition:	Any compound which can be used to treat or alleviate the symptoms of dyskinesia.
Synonyms:	related_synonym:	antidyskinesia agents; antidyskinesia drug; antidyskinesia drugs; antidyskinetic agent; antidyskinetic agents; antidyskinetic drug; antidyskinetic drugs

show annotations for term's descendants Sort by:
Rat (1547) Mouse (1527) Human (1537) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (1547)

(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dopamine receptor D1

multiple interactions
affects localization

A 77636 binds to and results in increased activity of DRD1 protein; SCH 23390 inhibits the reaction [A 77636 affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [A 77636 results in increased activity of DRD1 protein]

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

amantadine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

brain-derived neurotrophic factor

multiple interactions

[Fluoxetine co-treated with Amantadine] results in increased expression of BDNF mRNA

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

interferon, alpha-inducible protein 27

increases expression

Amantadine results in increased expression of IFI27 mRNA

NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294

G

interferon alpha and beta receptor subunit 1

affects expression

Amantadine affects the expression of IFNAR1 mRNA

NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979

G

Janus kinase 1

increases expression

Amantadine results in increased expression of JAK1 protein

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Amantadine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

microtubule-associated protein 2

decreases expression

Amantadine results in decreased expression of MAP2 mRNA

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

2'-5' oligoadenylate synthetase 2

increases expression

Amantadine results in increased expression of OAS2 mRNA

NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371

G

solute carrier family 47 member 1

multiple interactions

Amantadine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Amantadine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

signal transducer and activator of transcription 1

multiple interactions

[Amantadine co-treated with Ursodeoxycholic Acid co-treated with 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester] results in increased activity of STAT1

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

tyrosyl-DNA phosphodiesterase 1

decreases activity

Amantadine analog results in decreased activity of TDP1 protein

NCBI chr 6:119,163,192...119,231,029
Ensembl chr 6:119,163,166...119,231,021

apomorphine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amylase 2a3

multiple interactions

Apomorphine results in increased secretion of and results in increased activity of AMY1A protein; Atenolol inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein]; Metoclopramide inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein]

NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:201,317,920...201,326,532

G

arginine vasopressin

increases expression
multiple interactions

Apomorphine results in increased expression of AVP protein
Metoclopramide inhibits the reaction [Apomorphine results in increased expression of AVP protein]

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

bone morphogenetic protein 6

multiple interactions

Apomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Apomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

bone morphogenetic protein receptor type 1A

decreases expression

Apomorphine results in decreased expression of BMPR1A mRNA

NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616

G

cholecystokinin

multiple interactions
decreases activity

Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine]

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

cholecystokinin B receptor

affects response to substance

CCKBR protein affects the susceptibility to Apomorphine

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Apomorphine results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

dopamine receptor D1

multiple interactions

Apomorphine binds to and results in increased activity of DRD1 protein; SCH 23390 inhibits the reaction [Apomorphine results in increased activity of DRD1 protein]
[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]

PMID:8103921 PMID:15985612

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions
affects response to substance
increases response to substance

[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]
Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]
DRD2 protein affects the susceptibility to Apomorphine
DRD2 protein results in increased susceptibility to Apomorphine

PMID:2571179 PMID:7520908 PMID:8103596 PMID:8103921 PMID:14639100 More...

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

increases response to substance

DRD3 protein results in increased susceptibility to Apomorphine

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Apomorphine results in increased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

furin (paired basic amino acid cleaving enzyme)

decreases expression

Apomorphine results in decreased expression of FURIN mRNA

NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314

G

glial cell derived neurotrophic factor

multiple interactions

GDNF protein affects the susceptibility to [Apomorphine co-treated with Oxidopamine]

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

growth hormone 1

increases secretion
increases expression

Apomorphine results in increased secretion of GH1 protein
Apomorphine results in increased expression of GH1 protein

PMID:993808 PMID:8889285

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

hepcidin antimicrobial peptide

multiple interactions
decreases secretion
decreases expression

Apomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Apomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]; Apomorphine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Apomorphine results in decreased secretion of HAMP protein modified form
Apomorphine results in decreased expression of HAMP mRNA

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

5-hydroxytryptamine receptor 1A

multiple interactions

[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

5-hydroxytryptamine receptor 6

increases response to substance
multiple interactions

HTR6 protein results in increased susceptibility to Apomorphine
Ro4368554 inhibits the reaction [HTR6 protein results in increased susceptibility to Apomorphine]

NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912

G

interleukin 6

multiple interactions

Apomorphine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Apomorphine inhibits the reaction [Oxidopamine results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

ornithine decarboxylase 1

increases activity

Apomorphine results in increased activity of ODC1 protein

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

proenkephalin

multiple interactions

Apomorphine inhibits the reaction [Reserpine results in increased expression of PENK mRNA]

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

prolactin

decreases expression

Apomorphine results in decreased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

parvalbumin

affects expression

Apomorphine affects the expression of PVALB protein

NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561

G

regulator of G-protein signaling 9

affects response to substance

RGS9 affects the susceptibility to Apomorphine

NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892

G

sonic hedgehog signaling molecule

multiple interactions

SHH protein modified form affects the susceptibility to [Apomorphine co-treated with Oxidopamine]

NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170

G

solute carrier family 22 member 2

multiple interactions

Apomorphine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

synaptotagmin 7

multiple interactions

[Reserpine co-treated with Apomorphine] results in increased expression of SYT7 mRNA

NCBI chr 1:207,031,359...207,093,787
Ensembl chr 1:207,031,592...207,089,026

G

tachykinin, precursor 1

multiple interactions

Apomorphine promotes the reaction [Reserpine results in increased expression of TAC1 mRNA]

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

benserazide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catechol-O-methyltransferase

increases methylation

COMT protein results in increased methylation of Benserazide

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

dopa decarboxylase

multiple interactions

Benserazide binds to and results in decreased activity of DDC protein

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

dopamine receptor D1

multiple interactions

[Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein]

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions

[Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein]

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

benzatropine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Benztropine results in decreased activity of ABCB4 protein

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

acyl-CoA thioesterase 2

increases expression

Benztropine results in increased expression of ACOT2 protein

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

actin, beta-like 2

increases expression

Benztropine results in increased expression of ACTBL2 protein

NCBI chr 2:42,858,020...42,860,767
Ensembl chr 2:42,858,020...42,860,767

G

actin related protein 1A

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of ACTR1A protein

NCBI chr 1:245,237,821...245,256,618
Ensembl chr 1:245,237,826...245,256,495

G

actin related protein 3

decreases expression

Benztropine results in decreased expression of ACTR3 protein

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

G

adenylosuccinate lyase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of ADSL protein

NCBI chr 7:112,479,256...112,503,439
Ensembl chr 7:112,479,271...112,503,760

G

alkylglycerone phosphate synthase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of AGPS protein

NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830

G

adenylate kinase 1

decreases expression

Benztropine results in decreased expression of AK1 protein

NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041

G

annexin A1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of ANXA1 protein

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A5

decreases expression

Benztropine results in decreased expression of ANXA5 protein

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

annexin A6

decreases expression

Benztropine results in decreased expression of ANXA6 protein

NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433

G

annexin A7

increases expression

Benztropine results in increased expression of ANXA7 protein

NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385

G

acidic residue methyltransferase 1

increases expression

Benztropine results in increased expression of ARMT1 protein

NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

Benztropine results in decreased expression of ASNS protein

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

aspartate-beta-hydroxylase

increases expression

Benztropine results in increased expression of ASPH protein

NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

Benztropine results in increased expression of ATP2A3 protein

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

ATP synthase F1 subunit gamma

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of ATP5F1C protein

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367

G

ATPase H+ transporting V1 subunit B2

decreases expression

Benztropine results in decreased expression of ATP6V1B2 protein

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

ataxin 10

increases expression

Benztropine results in increased expression of ATXN10 protein

NCBI chr 7:116,441,768...116,565,093
Ensembl chr 7:116,441,613...116,565,087

G

bromodomain adjacent to zinc finger domain, 1B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of BAZ1B protein

NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426

G

BCAR1 scaffold protein, Cas family member

decreases expression

Benztropine results in decreased expression of BCAR1 protein

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

bridge-like lipid transfer protein family member 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of BLTP1 protein

NCBI chr 2:119,708,114...119,924,697
Ensembl chr 2:119,708,209...119,924,695

G

bone morphogenetic protein 6

increases expression

Benztropine results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

bromodomain containing 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of BRD2 protein

NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388

G

basigin (Ok blood group)

decreases expression

Benztropine results in decreased expression of BSG protein

NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387

G

caldesmon 1

decreases expression
multiple interactions

Benztropine results in decreased expression of CALD1 protein
[Cuprizone co-treated with Benztropine] results in decreased expression of CALD1 protein

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calumenin

decreases expression

Benztropine results in decreased expression of CALU protein

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

calcium/calmodulin-dependent protein kinase II delta

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of CAMK2D protein

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

G

cell cycle associated protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CAPRIN1 protein

NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502

G

caspase 8 associated protein 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CASP8AP2 protein

NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275

G

chromobox 5

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of CBX5 protein

NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022

G

cell division cycle and apoptosis regulator 1

increases expression

Benztropine results in increased expression of CCAR1 protein

NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526

G

coiled-coil domain containing 121

increases expression

Benztropine results in increased expression of CCDC121 protein

NCBI chr 6:24,970,845...24,973,451
Ensembl chr 6:24,970,833...24,973,478

G

chaperonin containing TCP1 subunit 6A

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CCT6A protein

NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337

G

chaperonin containing TCP1 subunit 7

decreases expression

Benztropine results in decreased expression of CCT7 protein

NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580

G

chaperonin containing TCP1 subunit 8

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CCT8 protein

NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079

G

Cd276 molecule

decreases expression

Benztropine results in decreased expression of CD276 protein

NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380

G

centromere protein V

increases expression

Benztropine results in increased expression of CENPV protein

NCBI chr10:47,214,479...47,228,552
Ensembl chr10:47,214,490...47,228,761

G

chromodomain helicase DNA binding protein 4

decreases expression

Benztropine results in decreased expression of CHD4 protein

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

creatine kinase B

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of CKB protein

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

2',3'-cyclic nucleotide 3' phosphodiesterase

multiple interactions
decreases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of CNP protein
Benztropine results in decreased expression of CNP protein

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

collagen type XIV alpha 1 chain

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of COL14A1 protein

NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214

G

collagen type V alpha 2 chain

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of COL5A2 protein

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

COP9 signalosome subunit 4

decreases expression

Benztropine results in decreased expression of COPS4 protein

NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887

G

coronin 1B

decreases expression

Benztropine results in decreased expression of CORO1B protein

NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416

G

coronin 7

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CORO7 protein

NCBI chr10:10,880,299...10,941,001
Ensembl chr10:10,885,196...10,941,001

G

copine 3

decreases expression

Benztropine results in decreased expression of CPNE3 protein

NCBI chr 5:33,014,658...33,063,934
Ensembl chr 5:33,016,307...33,063,934

G

cleavage and polyadenylation specific factor 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CPSF3 protein

NCBI chr 6:40,836,121...40,864,129
Ensembl chr 6:40,836,097...40,864,128

G

cartilage associated protein

increases expression

Benztropine results in increased expression of CRTAP protein

NCBI chr 8:114,047,929...114,067,636
Ensembl chr 8:114,047,933...114,067,631

G

crystallin zeta

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CRYZ protein

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

cold shock domain containing E1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CSDE1 protein

NCBI chr 2:190,546,015...190,582,787
Ensembl chr 2:190,554,980...190,582,784

G

cleavage stimulation factor subunit 2

decreases expression

Benztropine results in decreased expression of CSTF2 protein

NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476

G

C-terminal binding protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CTBP1 protein

NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821

G

cullin 2

increases expression

Benztropine results in increased expression of CUL2 protein

NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968

G

cullin 4B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CUL4B protein

NCBI chr X:117,287,481...117,326,688
Ensembl chr X:117,287,484...117,326,688

G

aspartyl-tRNA synthetase 2 (mitochondrial)

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of DARS2 protein

NCBI chr13:73,308,726...73,336,558
Ensembl chr13:73,308,726...73,336,934

G

DAZ associated protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of DAZAP1 protein

NCBI chr 7:9,423,673...9,448,116
Ensembl chr 7:9,424,178...9,538,818

G

dynactin subunit 2

increases expression

Benztropine results in increased expression of DCTN2 protein

NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543

G

DEAD-box helicase 17

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of DDX17 protein

NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193

G

DEAD-box helicase 3, X-linked

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of DDX3X protein

NCBI chr X:9,479,532...9,493,169
Ensembl chr X:9,479,532...9,493,168

G

DiGeorge syndrome critical region gene 6

decreases expression

Benztropine results in decreased expression of DGCR6 protein

NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823

G

24-dehydrocholesterol reductase

increases expression

Benztropine results in increased expression of DHCR24 protein

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

DEAH-box helicase 8

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of DHX8 protein

NCBI chr10:86,667,641...86,704,198
Ensembl chr10:86,667,834...86,705,137

G

dihydrolipoamide S-acetyltransferase

multiple interactions
increases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of DLAT protein
Benztropine results in increased expression of DLAT protein

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479

G

discs large MAGUK scaffold protein 2

increases expression

Benztropine results in increased expression of DLG2 protein

NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

Benztropine results in increased expression of DNAJB11 protein

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

dipeptidylpeptidase 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of DPP3 protein

NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541

G

dihydropyrimidinase-like 2

decreases expression

Benztropine results in decreased expression of DPYSL2 protein

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

dihydropyrimidinase-like 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of DPYSL3 protein

NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157

G

dynein cytoplasmic 1 light intermediate chain 1

decreases expression

Benztropine results in decreased expression of DYNC1LI1 protein

NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934

G

EBNA1 binding protein 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EBNA1BP2 protein

NCBI chr 5:132,148,164...132,152,730
Ensembl chr 5:132,148,143...132,153,267

G

eukaryotic translation elongation factor 1 gamma

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EEF1G protein

NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382

G

eukaryotic translation initiation factor 2 subunit gamma

increases expression

Benztropine results in increased expression of EIF2S3 protein

NCBI chr X:58,916,513...58,939,923
Ensembl chr X:58,917,490...58,940,686

G

eukaryotic translation initiation factor 3, subunit B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3B protein

NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886

G

eukaryotic translation initiation factor 3, subunit C

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3C protein

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 3, subunit H

decreases expression

Benztropine results in decreased expression of EIF3H protein

NCBI chr 7:83,091,037...83,174,451
Ensembl chr 7:83,091,039...83,174,451

G

eukaryotic translation initiation factor 3, subunit L

increases expression
multiple interactions

Benztropine results in increased expression of EIF3L protein
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3L protein

NCBI chr 7:110,652,565...110,663,614
Ensembl chr 7:110,627,107...110,663,614

G

eukaryotic translation initiation factor 5

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5 protein

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

eukaryotic translation initiation factor 5B

multiple interactions
increases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5B protein
Benztropine results in increased expression of EIF5B protein

NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482

G

eukaryotic translation initiation factor 6

decreases expression

Benztropine results in decreased expression of EIF6 protein

NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401

G

enolase 1

decreases expression

Benztropine results in decreased expression of ENO1 protein

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

Eph receptor B3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EPHB3 protein

NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370

G

Epsin 1

decreases expression

Benztropine results in decreased expression of EPN1 protein

NCBI chr 1:68,742,491...68,760,570
Ensembl chr 1:68,742,789...68,758,874

G

EGFR pathway substrate 8, signaling adaptor

decreases expression

Benztropine results in decreased expression of EPS8 protein

NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873

G

ERH, mRNA splicing and mitosis factor

increases expression

Benztropine results in increased expression of ERH protein

NCBI chr 6:100,280,933...100,291,200
Ensembl chr 6:100,280,930...100,291,210

G

ER lipid raft associated 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of ERLIN2 protein

NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671

G

EWS RNA-binding protein 1

decreases expression

Benztropine results in decreased expression of EWSR1 protein

NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544

G

exosome component 9

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EXOSC9 protein

NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051

G

ezrin

decreases expression

Benztropine results in decreased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

fatty acid binding protein 3

increases expression

Benztropine results in increased expression of FABP3 protein

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

farnesyl diphosphate synthase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of FDPS protein

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

flotillin 2

increases expression

Benztropine results in increased expression of FLOT2 protein

NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756

G

Fms related receptor tyrosine kinase 1

decreases expression

Benztropine results in decreased expression of FLT1 protein

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

FYVE and coiled-coil domain autophagy adaptor 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of FYCO1 protein

NCBI chr 8:123,412,105...123,479,315
Ensembl chr 8:123,412,112...123,479,021

G

G3BP stress granule assembly factor 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of G3BP2 protein

NCBI chr14:15,932,403...16,020,555
Ensembl chr14:15,987,417...16,020,548

G

glucose-6-phosphate dehydrogenase

decreases expression

Benztropine results in decreased expression of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

polypeptide N-acetylgalactosaminyltransferase 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of GALNT2 protein

NCBI chr19:52,213,226...52,324,816
Ensembl chr19:52,213,351...52,324,813

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GART protein

NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125

G

GATA zinc finger domain containing 2B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GATAD2B protein

NCBI chr 2:175,748,594...175,829,837
Ensembl chr 2:175,749,433...175,825,542

G

guanine deaminase

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of GDA protein

NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416

G

glutamine fructose-6-phosphate transaminase 1

decreases expression

Benztropine results in decreased expression of GFPT1 protein

NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471

G

gamma-glutamyl cyclotransferase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GGCT protein

NCBI chr 4:84,122,921...84,129,327
Ensembl chr 4:84,123,118...84,129,277

G

glutaredoxin 3

increases expression

Benztropine results in increased expression of GLRX3 protein

NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010

G

glutaminase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GLS protein

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

G protein subunit alpha 12

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GNA12 protein

NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255

G

golgin A4

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of GOLGA4 protein

NCBI chr 8:118,208,200...118,285,003

G

golgin B1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GOLGB1 protein

NCBI chr11:63,843,179...63,900,665
Ensembl chr11:63,843,986...63,900,770

G

glutamic-oxaloacetic transaminase 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of GOT2 protein

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glucose-6-phosphate isomerase

increases expression

Benztropine results in increased expression of GPI protein

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

G patch domain and KOW motifs

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GPKOW protein

NCBI chr X:14,791,601...14,806,384
Ensembl chr X:14,791,610...14,806,384

G

general transcription factor IIE subunit 1

decreases expression

Benztropine results in decreased expression of GTF2E1 protein

NCBI chr11:63,182,073...63,215,349
Ensembl chr11:63,182,349...63,213,942

G

general transcription factor IIF subunit 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GTF2F1 protein

NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423

G

GTP binding protein 4

increases expression

Benztropine results in increased expression of GTPBP4 protein

NCBI chr17:61,308,033...61,328,184
Ensembl chr17:61,308,014...61,418,009

G

glycogen synthase 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GYS1 protein

NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292

G

H2A clustered histone 20

increases expression

Benztropine results in increased expression of H2AC20 protein

NCBI chr 2:183,779,879...183,780,357

G

H2A.J histone

increases expression

Benztropine results in increased expression of H2AJ protein

NCBI chr 4:169,675,718...169,676,202
Ensembl chr 4:169,675,752...169,677,006

G

3-hydroxyacyl-CoA dehydratase 3

increases expression

Benztropine results in increased expression of HACD3 protein

NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

Benztropine results in increased expression of HADHB protein

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

histidyl-tRNA synthetase 1

increases expression

Benztropine results in increased expression of HARS1 protein

NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740

G

histone acetyltransferase 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of HAT1 protein

NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517

G

host cell factor C1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of HCFC1 protein

NCBI chr X:151,687,779...151,712,688
Ensembl chr X:151,687,779...151,712,638

G

hemicentin 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of HMCN2 protein

NCBI chr 3:14,588,353...14,738,320
Ensembl chr 3:14,588,662...14,738,025

G

heterogeneous nuclear ribonucleoprotein D

decreases expression

Benztropine results in decreased expression of HNRNPD protein

NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786

G

heterogeneous nuclear ribonucleoprotein K

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of HNRNPK protein

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

HPS3, biogenesis of lysosomal organelles complex 2 subunit 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of HPS3 protein

NCBI chr 2:102,484,574...102,527,580
Ensembl chr 2:102,484,574...102,526,047

G

hydroxysteroid (17-beta) dehydrogenase 12

increases expression

Benztropine results in increased expression of HSD17B12 protein

NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617

G

hydroxysteroid (17-beta) dehydrogenase 4

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of HSD17B4 protein

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

heat shock protein 90 beta family member 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of HSP90B1 protein

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

Benztropine results in decreased expression of IDI1 protein

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

interleukin 1 alpha

decreases expression

Benztropine results in decreased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

decreases expression

Benztropine results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

increases expression

Benztropine results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

junctional adhesion molecule 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of JAM3 protein

NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355

G

Jupiter microtubule associated homolog 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of JPT2 protein

NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170

G

lysyl-tRNA synthetase 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of KARS1 protein

NCBI chr19:39,957,846...39,976,837
Ensembl chr19:39,957,846...39,977,632

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Benztropine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium channel tetramerization domain containing 12

decreases expression

Benztropine results in decreased expression of KCTD12 protein

NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282

G

KH RNA binding domain containing, signal transduction associated 1

decreases expression

Benztropine results in decreased expression of KHDRBS1 protein

NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180

G

kinesin family member 5C

decreases expression

Benztropine results in decreased expression of KIF5C protein

NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413

G

kelch domain containing 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of KLHDC2 protein

NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187

G

kelch-like family member 41

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of KLHL41 protein

NCBI chr 3:54,434,291...54,447,415
Ensembl chr 3:54,434,234...54,449,222

G

karyopherin subunit alpha 4

increases expression

Benztropine results in increased expression of KPNA4 protein

NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081

G

kinectin 1

multiple interactions
decreases expression

[Cuprizone co-treated with Benztropine] results in increased expression of KTN1 protein
Benztropine results in decreased expression of KTN1 protein

NCBI chr15:20,913,665...21,002,588
Ensembl chr15:20,914,642...21,002,578

G

lactamase, beta 2

increases expression

Benztropine results in increased expression of LACTB2 protein

NCBI chr 5:5,569,080...5,591,843
Ensembl chr 5:5,569,067...5,596,429

G

laminin subunit beta 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of LAMB1 protein

NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585

G

laminin subunit gamma 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of LAMC1 protein

NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492

G

LIM domain and actin binding 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of LIMA1 protein

NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473

G

lipase A, lysosomal acid type

increases expression

Benztropine results in increased expression of LIPA protein

NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633

G

leiomodin 2

increases expression

Benztropine results in increased expression of LMOD2 protein

NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120

G

lanosterol synthase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of LSS protein

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

leukotriene A4 hydrolase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of LTA4H protein

NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600

G

LUC7-like

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of LUC7L protein

NCBI chr10:15,273,340...15,307,131
Ensembl chr10:15,273,348...15,303,112

G

MAGE family member A9

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of MAGEA9 protein

NCBI chr X:142,619,282...142,624,654
Ensembl chr X:142,619,395...142,624,653

G

MAGE family member D2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of MAGED2 protein

NCBI chr X:19,733,593...19,741,769
Ensembl chr X:19,733,597...19,740,477

G

microtubule-associated protein 1S

increases expression

Benztropine results in increased expression of MAP1S protein

NCBI chr16:18,516,759...18,527,777
Ensembl chr16:18,517,574...18,527,988

G

microtubule-associated protein 4

decreases expression

Benztropine results in decreased expression of MAP4 protein

NCBI chr 8:109,925,233...110,064,370
Ensembl chr 8:109,925,575...110,064,362

G

microtubule-associated protein, RP/EB family, member 1

decreases expression

Benztropine results in decreased expression of MAPRE1 protein

NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983

G

MARCKS-like 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of MARCKSL1 protein

NCBI chr 5:141,851,491...141,853,814
Ensembl chr 5:141,850,110...141,853,817

G

methionine adenosyltransferase 2 non-catalytic beta subunit

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of MAT2B protein

NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777

G

membrane bound O-acyltransferase domain containing 7

decreases expression

Benztropine results in decreased expression of MBOAT7 protein

NCBI chr 1:65,525,206...65,539,538
Ensembl chr 1:65,525,213...65,539,538

G

malate dehydrogenase 1

decreases expression

Benztropine results in decreased expression of MDH1 protein

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Benztropine results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

methionyl aminopeptidase 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of METAP2 protein

NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434

G

macrophage migration inhibitory factor

increases expression

Benztropine results in increased expression of MIF protein

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504

G

metadherin

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of MTDH protein

NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of MTHFD1L protein

NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905

G

myosin heavy chain 3

increases expression

Benztropine results in increased expression of MYH3 protein

NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992

G

N-acetyltransferase 10

decreases expression

Benztropine results in decreased expression of NAT10 protein

NCBI chr 3:90,111,643...90,149,891
Ensembl chr 3:90,111,645...90,149,927

G

nuclear cap binding protein subunit 1

decreases expression

Benztropine results in decreased expression of NCBP1 protein

NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089

G

nectin cell adhesion molecule 2

decreases expression

Benztropine results in decreased expression of NECTIN2 protein

NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360

G

nicotinamide N-methyltransferase

increases expression

Benztropine results in increased expression of NNMT protein

NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655

G

NOC2-like nucleolar associated transcriptional repressor

increases expression

Benztropine results in increased expression of NOC2L protein

NCBI chr 5:166,820,150...166,831,949
Ensembl chr 5:166,820,161...166,831,949

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

Benztropine results in decreased expression of NSF protein

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

NSFL1 cofactor

decreases expression

Benztropine results in decreased expression of NSFL1C protein

NCBI chr 3:139,978,306...140,002,876
Ensembl chr 3:139,978,301...140,002,870

G

nuclear mitotic apparatus protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of NUMA1 protein

NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855

G

nucleoporin 153

increases expression

Benztropine results in increased expression of NUP153 protein

NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876

G

nucleoporin 50

increases expression

Benztropine results in increased expression of NUP50 protein

NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905

G

nucleoporin 54

decreases expression

Benztropine results in decreased expression of NUP54 protein

NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028

G

nucleoporin 93

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of NUP93 protein

NCBI chr19:10,684,214...10,788,009
Ensembl chr19:10,682,075...10,788,026

G

nuclear RNA export factor 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of NXF1 protein

NCBI chr 1:205,655,442...205,668,637
Ensembl chr 1:205,655,375...205,668,636

G

ornithine aminotransferase

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of OAT protein

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

oxoglutarate dehydrogenase

decreases expression

Benztropine results in decreased expression of OGDH protein

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

Obg-like ATPase 1

increases expression

Benztropine results in increased expression of OLA1 protein

NCBI chr 3:57,966,896...58,085,955
Ensembl chr 3:57,966,896...58,084,480

G

prolyl 4-hydroxylase subunit beta

decreases expression

Benztropine results in decreased expression of P4HB protein

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

proliferation-associated 2G4

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PA2G4 protein

NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PAFAH1B1 protein

NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808

G

phosphoprotein membrane anchor with glycosphingolipid microdomains 1

decreases expression

Benztropine results in decreased expression of PAG1 protein

NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849

G

poly (ADP-ribose) polymerase 1

multiple interactions
decreases expression

[Cuprizone co-treated with Benztropine] results in increased expression of PARP1 protein
Benztropine results in decreased expression of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pyruvate carboxylase

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of PC protein

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

poly(rC) binding protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PCBP1 protein

NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500

G

poly(rC) binding protein 2

decreases expression

Benztropine results in decreased expression of PCBP2 protein

NCBI chr 7:133,605,375...133,631,312
Ensembl chr 7:133,605,573...133,629,863

G

protocadherin gamma subfamily A, 2

decreases expression

Benztropine results in decreased expression of PCDHGA2 protein

NCBI chr18:29,493,954...29,667,865
Ensembl chr18:29,493,954...29,667,868

G

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

decreases expression

Benztropine results in decreased expression of PCMT1 protein

NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201

G

PEST proteolytic signal containing nuclear protein

increases expression

Benztropine results in increased expression of PCNP protein

NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348

G

phosducin-like 3

decreases expression

Benztropine results in decreased expression of PDCL3 protein

NCBI chr 9:41,234,322...41,243,769
Ensembl chr 9:41,234,234...41,243,735

G

protein disulfide isomerase family A, member 3

decreases expression

Benztropine results in decreased expression of PDIA3 protein

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

G

protein disulfide isomerase family A, member 6

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PDIA6 protein

NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613

G

PDZ and LIM domain 5

decreases expression

Benztropine results in decreased expression of PDLIM5 protein

NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275

G

phosphatidylethanolamine binding protein 1

decreases expression

Benztropine results in decreased expression of PEBP1 protein

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

G

profilin 1

increases expression

Benztropine results in increased expression of PFN1 protein

NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631

G

phosphoglycerate kinase 1

decreases expression

Benztropine results in decreased expression of PGK1 protein

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

phosphoglucomutase 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PGM3 protein

NCBI chr 8:87,518,317...87,536,021
Ensembl chr 8:87,517,701...87,536,022

G

PHD finger protein 14

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PHF14 protein

NCBI chr 4:40,009,691...40,195,877
Ensembl chr 4:40,009,264...40,195,885

G

phosphoglycerate dehydrogenase

decreases expression

Benztropine results in decreased expression of PHGDH protein

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

phosphotyrosine interaction domain containing 1

increases expression

Benztropine results in increased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PIN1 protein

NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785

G

peptidase, mitochondrial processing subunit alpha

increases expression

Benztropine results in increased expression of PMPCA protein

NCBI chr 3:9,207,731...9,216,846
Ensembl chr 3:9,207,717...9,216,844

G

PNMA family member 1

increases expression

Benztropine results in increased expression of PNMA1 protein

NCBI chr 6:103,782,244...103,784,029
Ensembl chr 6:103,773,889...103,784,567

G

PNMA family member 8A

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PNMA8A protein

NCBI chr 1:77,629,272...77,643,156
Ensembl chr 1:77,639,423...77,642,082

G

paraoxonase 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PON3 protein

NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855

G

inorganic pyrophosphatase 1

multiple interactions
increases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of PPA1 protein
Benztropine results in increased expression of PPA1 protein

NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215

G

protein phosphatase, Mg2+/Mn2+ dependent, 1F

decreases expression

Benztropine results in decreased expression of PPM1F protein

NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340

G

protein phosphatase 1, regulatory subunit 12A

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of PPP1R12A protein

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

G

protein phosphatase 1, regulatory (inhibitor) subunit 14B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PPP1R14B protein

NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319

G

protein phosphatase 3 catalytic subunit alpha

increases expression

Benztropine results in increased expression of PPP3CA protein

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

protein kinase cAMP-dependent type II regulatory subunit alpha

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PRKAR2A protein

NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628

G

PRKCSH beta subunit of glucosidase II

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of PRKCSH protein

NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492

G

protein arginine methyltransferase 1

decreases expression

Benztropine results in decreased expression of PRMT1 protein

NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345

G

pre-mRNA processing factor 6

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PRPF6 protein

NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991

G

proteasome 20S subunit alpha 1

decreases expression

Benztropine results in decreased expression of PSMA1 protein

NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472

G

proteasome 20S subunit beta 7

decreases expression

Benztropine results in decreased expression of PSMB7 protein

NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937

G

proteasome 26S subunit, ATPase 1

decreases expression

Benztropine results in decreased expression of PSMC1 protein

NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123

G

proteasome 26S subunit, ATPase 3

increases expression

Benztropine results in increased expression of PSMC3 protein

NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358

G

proteasome 26S subunit, non-ATPase 7

increases expression

Benztropine results in increased expression of PSMD7 protein

NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588

G

Pentatricopeptide repeat domain 3

increases expression
multiple interactions

Benztropine results in increased expression of PTCD3 protein
[Cuprizone co-treated with Benztropine] results in decreased expression of PTCD3 protein

NCBI chr 4:103,922,440...103,957,445
Ensembl chr 4:103,920,566...103,957,538

G

prostaglandin-endoperoxide synthase 2

decreases expression

Benztropine results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 7

decreases expression

Benztropine results in decreased expression of PTK7 protein

NCBI chr 9:14,352,155...14,418,473
Ensembl chr 9:14,351,202...14,418,494

G

poly-U binding splicing factor 60

decreases expression

Benztropine results in decreased expression of PUF60 protein

NCBI chr 7:107,782,799...107,793,759
Ensembl chr 7:107,782,770...107,794,531

G

PWP2, small subunit processome component

increases expression

Benztropine results in increased expression of PWP2 protein

NCBI chr20:10,499,332...10,512,965
Ensembl chr20:10,499,363...10,513,640

G

pyrroline-5-carboxylate reductase 1

increases expression

Benztropine results in increased expression of PYCR1 protein

NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549

G

quinoid dihydropteridine reductase

decreases expression

Benztropine results in decreased expression of QDPR protein

NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854

G

receptor for activated C kinase 1

decreases expression

Benztropine results in decreased expression of RACK1 protein

NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975

G

RNA binding motif protein 15

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of RBM15 protein

NCBI chr 2:194,945,974...194,954,498
Ensembl chr 2:194,945,974...194,954,703

G

RIC8 guanine nucleotide exchange factor A

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of RIC8A protein

NCBI chr 1:195,935,162...195,941,469
Ensembl chr 1:195,935,349...195,941,467

G

ribosomal protein L10A

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of RPL10A protein

NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357

G

ribosomal protein L19

increases expression

Benztropine results in increased expression of RPL19 protein

NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112

G

ribosomal protein L24

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of RPL24 protein

NCBI chr11:44,653,937...44,659,346
Ensembl chr11:44,653,937...44,659,370

G

ribosomal protein L30

increases expression

Benztropine results in increased expression of RPL30 protein

NCBI chr 7:65,648,266...65,651,401
Ensembl chr 7:65,645,991...65,651,363
Ensembl chr10:65,645,991...65,651,363
Ensembl chr10:65,645,991...65,651,363

G

ribosomal protein L7A

decreases expression

Benztropine results in decreased expression of RPL7A protein

NCBI chr 3:10,239,026...10,241,703
Ensembl chr 3:10,239,001...10,241,716

G

ribosomal protein lateral stalk subunit P1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of RPLP1 protein

NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339

G

ribosomal protein S12

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of RPS12 protein

NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014

G

ribosomal protein S18

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of RPS18 protein

NCBI chr20:4,931,427...4,935,538
Ensembl chr10:101,204,500...101,205,146
Ensembl chr20:101,204,500...101,205,146

G

ribosomal protein S27

increases expression

Benztropine results in increased expression of RPS27 protein

NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964

G

ribosomal protein S27a

increases expression

Benztropine results in increased expression of RPS27A protein

NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011

G

ribosomal protein S3

decreases expression

Benztropine results in decreased expression of RPS3 protein

NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680

G

RuvB-like AAA ATPase 2

increases expression

Benztropine results in increased expression of RUVBL2 protein

NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342

G

SUMO1 activating enzyme subunit 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SAE1 protein

NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986

G

seryl-tRNA synthetase 1

decreases expression

Benztropine results in decreased expression of SARS1 protein

NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277

G

SATB homeobox 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of SATB2 protein

NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707

G

saccharopine dehydrogenase (putative)

decreases expression

Benztropine results in decreased expression of SCCPDH protein

NCBI chr13:91,400,120...91,421,875
Ensembl chr13:91,400,190...91,422,222

G

syndecan binding protein

decreases expression

Benztropine results in decreased expression of SDCBP protein

NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572

G

Sec23 homolog A, COPII coat complex component

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of SEC23A protein

NCBI chr 6:76,658,793...76,706,125
Ensembl chr 6:76,658,427...76,706,035

G

SEC61 translocon subunit beta

increases expression

Benztropine results in increased expression of SEC61B protein

NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804

G

SEC63 homolog, protein translocation regulator

increases expression

Benztropine results in increased expression of SEC63 protein

NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055

G

Serpine1 mRNA binding protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SERBP1 protein

NCBI chr 4:96,401,587...96,421,816
Ensembl chr 4:96,401,477...96,421,813

G

serpin family B member 3A

increases expression

Benztropine results in increased expression of SERPINB4 protein

NCBI chr13:23,241,303...23,246,328
Ensembl chr13:23,236,972...23,246,985

G

splicing factor 1

decreases expression

Benztropine results in decreased expression of SF1 protein

NCBI chr 1:203,670,016...203,683,432
Ensembl chr 1:203,670,018...203,684,330

G

splicing factor 3b, subunit 3

decreases expression

Benztropine results in decreased expression of SF3B3 protein

NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245

G

sarcoglycan, alpha

decreases expression

Benztropine results in decreased expression of SGCA protein

NCBI chr10:79,904,698...79,922,808
Ensembl chr10:79,908,738...79,922,813

G

SH3 and PX domains 2B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SH3PXD2B protein

NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170

G

serine hydroxymethyltransferase 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SHMT1 protein

NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820

G

solute carrier family 22 member 2

multiple interactions

Benztropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 25 member 6

increases expression

Benztropine results in increased expression of SLC25A6 protein

NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199

G

solute carrier family 2 member 1

decreases expression

Benztropine results in decreased expression of SLC2A1 protein

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 38, member 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of SLC38A2 protein

NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 3 member 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of SLC3A2 protein

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 6 member 3

multiple interactions

Benztropine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

secretory leukocyte peptidase inhibitor

increases expression

Benztropine results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

decreases expression

Benztropine results in decreased expression of SMARCB1 protein

NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620

G

structural maintenance of chromosomes 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SMC3 protein

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

SMU1, DNA replication regulator and spliceosomal factor

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SMU1 protein

NCBI chr 5:55,856,691...55,875,262
Ensembl chr 5:55,856,246...55,875,300

G

small nuclear ribonucleoprotein U5 subunit 200

multiple interactions
increases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of SNRNP200 protein
Benztropine results in increased expression of SNRNP200 protein

NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182

G

small nuclear ribonucleoprotein polypeptide A

increases expression

Benztropine results in increased expression of SNRPA protein

NCBI chr 1:82,481,770...82,490,540
Ensembl chr 1:82,481,770...82,490,538

G

small nuclear ribonucleoprotein D2 polypeptide

increases expression

Benztropine results in increased expression of SNRPD2 protein

NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351

G

splicing regulatory glutamic acid and lysine rich protein 1

decreases expression

Benztropine results in decreased expression of SREK1 protein

NCBI chr 2:34,849,548...34,885,120
Ensembl chr 2:34,852,458...34,884,972

G

serine and arginine rich splicing factor 5

increases expression

Benztropine results in increased expression of SRSF5 protein

NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177

G

signal transducer and activator of transcription 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

stromal interaction molecule 1

decreases expression

Benztropine results in decreased expression of STIM1 protein

NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363

G

stress-induced phosphoprotein 1

decreases expression

Benztropine results in decreased expression of STIP1 protein

NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476

G

serine/threonine kinase receptor associated protein

decreases expression

Benztropine results in decreased expression of STRAP protein

NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828

G

STIP1 homology and U-box containing protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of STUB1 protein

NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

decreases expression

Benztropine results in decreased expression of SUCLG1 protein

NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600

G

small ubiquitin-like modifier 2

decreases expression

Benztropine results in decreased expression of SUMO2 protein

NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513

G

Sad1 and UNC84 domain containing 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SUN1 protein

NCBI chr12:15,396,378...15,441,277
Ensembl chr12:15,396,381...15,441,571

G

synaptotagmin binding, cytoplasmic RNA interacting protein

decreases expression

Benztropine results in decreased expression of SYNCRIP protein

NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515

G

transgelin 2

decreases expression

Benztropine results in decreased expression of TAGLN2 protein

NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972

G

tubulin folding cofactor B

decreases expression

Benztropine results in decreased expression of TBCB protein

NCBI chr 1:85,477,639...85,483,488
Ensembl chr 1:85,477,640...85,483,488

G

TRPM8 channel-associated factor 1

multiple interactions
decreases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of TCAF1 protein
Benztropine results in decreased expression of TCAF1 protein

NCBI chr 4:71,589,674...71,639,274
Ensembl chr 4:71,591,200...71,613,309

G

trans-golgi network protein 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of TGOLN2 protein

NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164

G

talin 2

decreases expression

Benztropine results in decreased expression of TLN2 protein

NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219

G

thymopoietin

decreases expression

Benztropine results in decreased expression of TMPO protein

NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727

G

tankyrase 1 binding protein 1

multiple interactions
decreases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of TNKS1BP1 protein
Benztropine results in decreased expression of TNKS1BP1 protein

NCBI chr 3:70,135,335...70,160,071
Ensembl chr 3:70,137,837...70,160,038

G

translocase of outer mitochondrial membrane 34

decreases expression
multiple interactions

Benztropine results in decreased expression of TOMM34 protein
[Cuprizone co-treated with Benztropine] results in increased expression of TOMM34 protein

NCBI chr 3:152,729,345...152,746,295
Ensembl chr 3:152,729,349...152,746,373

G

DNA topoisomerase I mitochondrial

increases expression

Benztropine results in increased expression of TOP1MT protein

NCBI chr 7:107,338,092...107,368,125
Ensembl chr 7:107,342,527...107,366,049

G

tropomyosin 2

decreases expression

Benztropine results in decreased expression of TPM2 protein

NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992

G

tropomyosin 3

decreases expression

Benztropine results in decreased expression of TPM3 protein

NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013

G

translocated promoter region, nuclear basket protein

decreases expression

Benztropine results in decreased expression of TPR protein

NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496

G

tripartite motif-containing 28

decreases expression
multiple interactions

Benztropine results in decreased expression of TRIM28 protein
[Cuprizone co-treated with Benztropine] results in increased expression of TRIM28 protein

NCBI chr 1:73,652,441...73,659,388
Ensembl chr 1:73,652,709...73,659,380

G

tetraspanin 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of TSPAN3 protein

NCBI chr 8:56,546,067...56,569,815
Ensembl chr 8:56,546,069...56,569,880

G

tetratricopeptide repeat domain 21A

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of TTC21A protein

NCBI chr 8:119,667,044...119,702,028
Ensembl chr 8:119,666,933...119,702,456

G

tweety family member 2

increases expression

Benztropine results in increased expression of TTYH2 protein

NCBI chr10:99,709,063...99,753,449
Ensembl chr10:99,709,007...99,753,444

G

tweety family member 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of TTYH3 protein

NCBI chr12:13,996,831...14,025,457
Ensembl chr12:13,997,045...14,025,459

G

tubulin, beta 5 class I

increases expression

Benztropine results in increased expression of TUBB protein

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

twinfilin actin-binding protein 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of TWF2 protein

NCBI chr 8:106,845,253...106,858,298
Ensembl chr 8:106,845,253...106,858,298

G

taxilin alpha

decreases expression

Benztropine results in decreased expression of TXLNA protein

NCBI chr 5:141,969,337...141,985,054
Ensembl chr 5:141,969,346...141,984,583

G

thymidylate synthetase

increases expression

Benztropine results in increased expression of TYMS protein

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

U2 small nuclear RNA auxiliary factor 2

decreases expression

Benztropine results in decreased expression of U2AF2 protein

NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492

G

ubiquitin-like modifier activating enzyme 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of UBA2 protein

NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682

G

ubiquitin associated protein 2-like

decreases expression

Benztropine results in decreased expression of UBAP2L protein

NCBI chr 2:175,438,703...175,494,085
Ensembl chr 2:175,438,703...175,493,998

G

ubiquitin C

increases expression

Benztropine results in increased expression of UBC protein

NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925

G

ubiquilin 2

decreases expression

Benztropine results in decreased expression of UBQLN2 protein

NCBI chr X:17,853,086...17,856,505
Ensembl chr X:17,853,114...17,856,505

G

ubiquitin C-terminal hydrolase L1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of UCHL1 protein

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

G

ubiquitin C-terminal hydrolase L3

decreases expression

Benztropine results in decreased expression of UCHL3 protein

NCBI chr15:78,485,304...78,527,355
Ensembl chr15:78,485,315...78,527,355
Ensembl chr 3:78,485,315...78,527,355

G

UDP-glucose 6-dehydrogenase

decreases expression

Benztropine results in decreased expression of UGDH protein

NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354

G

unc-45 myosin chaperone B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of UNC45B protein

NCBI chr10:67,845,464...67,873,143
Ensembl chr10:67,845,462...67,873,389

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of UQCRC2 protein

NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453

G

USO1 vesicle transport factor

decreases expression

Benztropine results in decreased expression of USO1 protein

NCBI chr14:15,866,638...15,932,185
Ensembl chr14:15,866,638...15,932,171

G

ubiquitin specific peptidase 10

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of USP10 protein

NCBI chr19:47,972,858...48,014,900
Ensembl chr19:47,972,611...48,014,897

G

ubiquitin specific peptidase 14

increases expression

Benztropine results in increased expression of USP14 protein

NCBI chr18:1,018,111...1,057,727
Ensembl chr18:1,019,400...1,057,519

G

UTP18 small subunit processome component

increases expression

Benztropine results in increased expression of UTP18 protein

NCBI chr10:78,811,879...78,839,338
Ensembl chr10:78,811,880...78,839,627

G

vasodilator-stimulated phosphoprotein

decreases expression

Benztropine results in decreased expression of VASP protein

NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061

G

tryptophanyl-tRNA synthetase 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of WARS1 protein

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

WD repeat domain 12

decreases expression

Benztropine results in decreased expression of WDR12 protein

NCBI chr 9:61,475,498...61,502,762
Ensembl chr 9:61,475,517...61,502,469

G

xin actin-binding repeat containing 2

decreases expression

Benztropine results in decreased expression of XIRP2 protein

NCBI chr 3:52,126,213...52,213,094
Ensembl chr 3:51,870,092...52,213,091

G

exportin 7

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of XPO7 protein

NCBI chr15:45,742,053...45,828,050
Ensembl chr15:45,742,053...45,828,050

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

increases expression

Benztropine results in increased expression of YWHAQ protein

NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273

G

zinc finger and BTB domain containing 42

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of ZBTB42 protein

NCBI chr 6:131,734,257...131,742,459
Ensembl chr 6:131,738,356...131,742,685

G

zinc finger RNA binding protein

decreases expression

Benztropine results in decreased expression of ZFR protein

NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322

G

zinc finger with KRAB and SCAN domains 7

decreases expression

Benztropine results in decreased expression of ZKSCAN7 protein

NCBI chr 8:122,501,938...122,519,600
Ensembl chr 8:122,502,218...122,519,600

biperiden

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Biperiden results in decreased activity of ABCB4 protein

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

bone morphogenetic protein 6

increases expression

Biperiden results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

cholinergic receptor, muscarinic 1

multiple interactions

Biperiden binds to and results in decreased activity of CHRM1 protein

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

epiregulin

increases expression

Biperiden results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

interleukin 1 alpha

increases expression

Biperiden results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

Biperiden results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

increases expression

Biperiden results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Biperiden results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

phosphotyrosine interaction domain containing 1

increases expression

Biperiden results in increased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

solute carrier family 7 member 11

increases expression

Biperiden results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

bromocriptine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression
multiple interactions

Bromocriptine results in increased expression of ABCB1 protein
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Spiperone inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases activity
increases expression
multiple interactions

Bromocriptine results in increased activity of ABCB1B promoter
Bromocriptine results in increased expression of ABCB1B mRNA
Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; eticlopride inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Pertussis Toxin inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Spiperone inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

aldo-keto reductase family 1, member C3

increases expression
multiple interactions

Bromocriptine results in increased expression of AKR1C3 mRNA
methyl cellosolve inhibits the reaction [Bromocriptine results in increased expression of AKR1C3 mRNA]

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

activating transcription factor 3

increases expression

Bromocriptine results in increased expression of ATF3 mRNA; Bromocriptine results in increased expression of ATF3 protein

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Bromocriptine results in increased expression of BAX protein
[Bromocriptine co-treated with Octreotide] results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

brain-derived neurotrophic factor

decreases secretion

Bromocriptine results in decreased secretion of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

catenin beta 1

multiple interactions

[Bromocriptine co-treated with Estradiol] results in decreased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
decreases expression

Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of CYP11A1 mRNA]
Bromocriptine results in decreased expression of CYP11A1 protein

PMID:12742521 PMID:21427058

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

Bromocriptine results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Bromocriptine results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects binding
affects metabolic processing
multiple interactions

Bromocriptine binds to CYP3A4 protein
CYP3A4 protein affects the metabolism of Bromocriptine
Bromocriptine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]

PMID:15286053 PMID:17198380 PMID:19299527

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dopamine beta-hydroxylase

decreases activity

Bromocriptine results in decreased activity of DBH protein

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

dopamine receptor D2

affects expression
affects response to substance
multiple interactions
decreases expression
increases expression
increases response to substance

Bromocriptine affects the expression of DRD2 mRNA
DRD2 protein affects the susceptibility to Bromocriptine
Bromocriptine binds to and results in increased activity of DRD2 mRNA; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]
Bromocriptine results in decreased expression of DRD2 mRNA
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Bromocriptine results in increased expression of DRD2 mRNA
DRD2 polymorphism results in increased susceptibility to Bromocriptine

PMID:1534540 PMID:8103596 PMID:15781964 PMID:16901644 PMID:20063113

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

multiple interactions
decreases expression

[1-Methyl-4-phenylpyridinium co-treated with Bromocriptine] results in decreased expression of DRD3 mRNA
Bromocriptine results in decreased expression of DRD3 mRNA

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

estrogen receptor 1

multiple interactions

[Bromocriptine co-treated with Estradiol] results in increased expression of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

follicle stimulating hormone subunit beta

increases expression

Bromocriptine results in increased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

glial cell derived neurotrophic factor

decreases expression
decreases secretion

Bromocriptine results in decreased expression of GDNF mRNA
Bromocriptine results in decreased secretion of GDNF protein

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

growth hormone 1

increases expression
decreases expression

Bromocriptine results in increased expression of GH1 protein
Bromocriptine results in decreased expression of GH1 protein

PMID:772175 PMID:3226523 PMID:3745407 PMID:7293648 PMID:19420816

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

heme oxygenase 1

increases expression

Bromocriptine results in increased expression of HMOX1 mRNA; Bromocriptine results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

5-hydroxytryptamine receptor 7

multiple interactions

[Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Bromocriptine binds to and results in decreased activity of HTR7 protein

PMID:18996971 PMID:19509219

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

G

insulin 2

decreases expression

Bromocriptine results in decreased expression of INS protein

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

luteinizing hormone subunit beta

increases expression

Bromocriptine results in increased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

mitogen activated protein kinase 1

multiple interactions

Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

NFE2 like bZIP transcription factor 2

increases localization

Bromocriptine results in increased localization of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nerve growth factor

increases secretion

Bromocriptine results in increased secretion of NGF protein

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nitric oxide synthase 2

multiple interactions

Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 5, group A, member 2

multiple interactions

Bromocriptine affects the reaction [methyl cellosolve results in increased expression of NR5A2 mRNA]

NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326

G

proliferating cell nuclear antigen

multiple interactions

[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

proopiomelanocortin

decreases expression
increases expression
multiple interactions

Bromocriptine results in decreased expression of POMC protein alternative form
Bromocriptine results in increased expression of POMC mRNA; Bromocriptine results in increased expression of POMC protein modified form
Bromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone]

PMID:1325994 PMID:6274577 PMID:12742521

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

protein kinase C, delta

multiple interactions
affects localization

Bromocriptine promotes the reaction [Estrogens results in increased expression of and results in increased cleavage of PRKCD protein]
Bromocriptine affects the localization of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

prolactin

multiple interactions
decreases secretion
decreases expression

Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Nalorphine results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein]
Bromocriptine results in decreased secretion of PRL protein
Bromocriptine results in decreased expression of PRL protein
Bromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Estradiol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of PRL protein]; Estradiol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Ethanol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]

PMID:86031 PMID:86795 PMID:90217 PMID:1407345 PMID:1874184 More...

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

scavenger receptor class B, member 1

multiple interactions

Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of SCARB1 mRNA]

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

superoxide dismutase 1

multiple interactions

Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

steroidogenic acute regulatory protein

decreases expression

Bromocriptine results in decreased expression of STAR protein

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 5A

affects localization

Bromocriptine affects the localization of STAT5A protein

NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866

G

transforming growth factor alpha

multiple interactions

Bromocriptine inhibits the reaction [Estradiol results in increased expression of TGFA mRNA]

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

multiple interactions

[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of TGFB1 protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein]
Bromocriptine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:11752888 PMID:21867702

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

multiple interactions

[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VEGFA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vasoactive intestinal peptide

multiple interactions

Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein]
[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]

PMID:6441721 PMID:15677882

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

cabergoline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

brain-derived neurotrophic factor

increases expression

Cabergoline results in increased expression of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

cAMP responsive element binding protein 1

increases expression

Cabergoline results in increased expression of CREB1 protein modified form

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

dopamine receptor D2

multiple interactions

Cabergoline binds to and results in increased activity of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

glial cell derived neurotrophic factor

increases expression
increases secretion

cabergoline results in increased expression of GDNF mRNA
cabergoline results in increased secretion of GDNF protein

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

nerve growth factor

increases expression
increases secretion

cabergoline results in increased expression of NGF mRNA
cabergoline results in increased secretion of NGF protein

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

prolactin

decreases expression
multiple interactions
decreases secretion

cabergoline results in decreased expression of PRL protein
Haloperidol inhibits the reaction [cabergoline results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [cabergoline results in decreased secretion of PRL protein]

PMID:2570719 PMID:3745407 PMID:7670571 PMID:15377706

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

carbidopa

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Carbidopa inhibits the reaction [Cisplatin results in increased expression of BAX protein]
Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]

PMID:34560070 PMID:35202708

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

PMID:34560070 PMID:35202708

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]

PMID:34560070 PMID:35202708

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]

PMID:34560070 PMID:35202708

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catechol-O-methyltransferase

increases methylation

COMT protein results in increased methylation of Carbidopa

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

dopa decarboxylase

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]
Carbidopa binds to and results in decreased activity of DDC protein

PMID:35151785 PMID:35202708

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

dynamin 1-like

multiple interactions

Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

fission, mitochondrial 1

multiple interactions

Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]

NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377

G

glutamic--pyruvic transaminase

multiple interactions

Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

interleukin 1 beta

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]; Carbidopa inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

monoamine oxidase A

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]; Carbidopa inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]

PMID:34560070 PMID:35202708

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

mitofusin 1

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]

NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640

G

mitochondrially encoded ATP synthase membrane subunit 6

multiple interactions

Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]

NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599

G

mitochondrially encoded cytochrome b

multiple interactions

Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]

NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]

NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]; Carbidopa inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

signal transducer and activator of transcription 3

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tumor necrosis factor

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of TNF protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of TNF protein]; Carbidopa inhibits the reaction [Cisplatin results in increased secretion of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tryptophan hydroxylase 1

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]

NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344

carbinoxamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

carbinoxamine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

solute carrier family 22 member 2

multiple interactions

carbinoxamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

dimenhydrinate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

decreases activity

Dimenhydrinate results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

solute carrier family 22 member 2

multiple interactions

Dimenhydrinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

diphenhydramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

autophagy related 5

affects response to substance

ATG5 protein affects the susceptibility to Diphenhydramine

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

butyrylcholinesterase

multiple interactions
decreases activity

Protons affects the reaction [Diphenhydramine results in decreased activity of BCHE protein]

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

bone morphogenetic protein 6

decreases expression

Diphenhydramine results in decreased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

epiregulin

decreases expression

Diphenhydramine results in decreased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

coagulation factor III, tissue factor

multiple interactions

Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

G protein subunit alpha i1

increases response to substance

GNAI1 results in increased susceptibility to Diphenhydramine

NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417

G

G protein subunit alpha i2

increases response to substance

GNAI2 results in increased susceptibility to Diphenhydramine

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

histamine receptor H 1

multiple interactions

Diphenhydramine binds to and results in decreased activity of HRH1 protein; Diphenhydramine binds to and results in increased activity of HRH1 protein; Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein]
[Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin

PMID:1912125 PMID:2419744 PMID:2461127 PMID:7522859 PMID:9609743 More...

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

interleukin 1 beta

increases expression
decreases expression

Diphenhydramine results in increased expression of IL1B mRNA
Diphenhydramine results in decreased expression of IL1B mRNA

PMID:28138970 PMID:32816093

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

decreases expression

Diphenhydramine results in decreased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 6

multiple interactions

Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen-activated protein kinase 8

increases activity

Diphenhydramine results in increased activity of MAPK8

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

[Diphenhydramine co-treated with PK 11195] binds to and results in increased activity of NR1I3 protein alternative form

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

phospholipase A2 group IVA

multiple interactions

Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

G

prostaglandin-endoperoxide synthase 2

decreases expression

Diphenhydramine results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

solute carrier family 22 member 1

multiple interactions

Diphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

multiple interactions

Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

PMID:16263091 PMID:21599003

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

multiple interactions

Diphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 22 member 5

multiple interactions

Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 7 member 11

decreases expression

Diphenhydramine results in decreased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

secretory leukocyte peptidase inhibitor

increases expression

Diphenhydramine results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

entacapone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA oxidase 3, pristanoyl

affects binding

entacapone binds to ACOX3 protein

NCBI chr14:75,133,986...75,176,767
Ensembl chr14:75,094,676...75,176,205

G

acyl-CoA synthetase long-chain family member 1

affects binding

entacapone binds to ACSL1 protein

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

ADP-ribosylhydrolase like 1

affects binding

entacapone binds to ADPRHL1 protein

NCBI chr16:76,283,186...76,315,075
Ensembl chr16:76,283,103...76,354,440

G

AU RNA binding methylglutaconyl-CoA hydratase

affects binding

entacapone binds to AUH protein

NCBI chr17:12,329,522...12,424,882
Ensembl chr17:12,329,524...12,424,896

G

clathrin heavy chain

affects binding

entacapone binds to CLTC protein

NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737

G

catechol-O-methyltransferase

decreases activity
affects binding
multiple interactions

entacapone results in decreased activity of COMT protein
entacapone binds to COMT protein
[entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; entacapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]

PMID:12898346 PMID:15566291 PMID:19783845 PMID:20334432 PMID:23206800 More...

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

enoyl-CoA hydratase, short chain 1

affects binding

entacapone binds to ECHS1 protein

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

epiregulin

increases expression

entacapone results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression

entacapone results in decreased expression of GPAM protein

NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639

G

hemoglobin subunit beta

affects binding

entacapone binds to HBB protein

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

hydroxysteroid (17-beta) dehydrogenase 13

affects binding

entacapone binds to HSD17B13 protein

NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166

G

hydroxysteroid (17-beta) dehydrogenase 4

affects binding

entacapone binds to HSD17B4 protein

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

interleukin 1 alpha

increases expression

entacapone results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

entacapone results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

entacapone results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

pyruvate carboxylase

affects binding

entacapone binds to PC protein

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

phosphotyrosine interaction domain containing 1

decreases expression

entacapone results in decreased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

prostaglandin-endoperoxide synthase 2

increases expression

entacapone results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

solute carrier family 7 member 11

decreases expression

entacapone results in decreased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

secretory leukocyte peptidase inhibitor

decreases expression

entacapone results in decreased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

synuclein alpha

multiple interactions

entacapone inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

sulfotransferase family 2A member 1

affects binding

entacapone binds to SULT2A1 protein

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

TNF alpha induced protein 6

decreases expression

entacapone results in decreased expression of TNFAIP6 mRNA

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of entacapone

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of entacapone

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation
decreases glucuronidation

UGT1A9 protein results in increased glucuronidation of entacapone
UGT1A9 protein mutant form results in decreased glucuronidation of entacapone

PMID:15044611 PMID:15802387 PMID:16344532

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

haloperidol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases expression
decreases activity

Haloperidol inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]
Haloperidol results in decreased expression of ABCB1 mRNA
Haloperidol results in decreased activity of ABCB1 protein

PMID:15946544 PMID:16810505

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

multiple interactions
decreases expression

Haloperidol inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]
Haloperidol results in decreased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily G member 2

multiple interactions

Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

acyl-CoA dehydrogenase, very long chain

decreases expression

Haloperidol results in decreased expression of ACADVL protein

NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075

G

acetyl-CoA acetyltransferase 1

decreases expression

Haloperidol results in decreased expression of ACAT1 protein

NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855

G

acyl-CoA synthetase long-chain family member 3

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of ACSL3 protein

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

ADAM metallopeptidase domain 1a

decreases expression

Haloperidol results in decreased expression of ADAM1A mRNA

NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311

G

adenylate cyclase 5

affects response to substance
multiple interactions

ADCY5 protein affects the susceptibility to Haloperidol
SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Haloperidol]

NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974

G

ADCYAP receptor type I

affects expression

Haloperidol affects the expression of ADCYAP1R1 mRNA

NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700

G

adenosine A2a receptor

affects response to substance

ADORA2A protein affects the susceptibility to Haloperidol

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adenylosuccinate lyase

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of ADSL protein

NCBI chr 7:112,479,256...112,503,439
Ensembl chr 7:112,479,271...112,503,760

G

1-acylglycerol-3-phosphate O-acyltransferase 1

decreases expression

Haloperidol results in decreased expression of AGPAT1 mRNA

NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278

G

alkylglycerone phosphate synthase

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of AGPS protein

NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830

G

adenylate kinase 4

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of AK4 protein

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

AKT serine/threonine kinase 1

decreases expression

Haloperidol results in decreased expression of AKT1 mRNA

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

increases expression

Haloperidol results in increased expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

aldehyde dehydrogenase 18 family, member A1

decreases expression

Haloperidol results in decreased expression of ALDH18A1 protein

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldolase, fructose-bisphosphate A

increases expression

Haloperidol results in increased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate C

increases expression

Haloperidol results in increased expression of ALDOC mRNA

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

ankyrin repeat and KH domain containing 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of ANKHD1 protein

NCBI chr18:28,161,882...28,260,917
Ensembl chr18:28,162,311...28,268,024

G

adaptor related protein complex 2 subunit alpha 2

decreases expression

Haloperidol results in decreased expression of AP2A2 mRNA

NCBI chr 1:196,652,315...196,725,609
Ensembl chr 1:196,652,337...196,725,603

G

adaptor related protein complex 2 subunit beta 1

affects expression

Haloperidol affects the expression of AP2B1 mRNA

NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013

G

adaptor related protein complex 2 subunit mu 1

increases expression

Haloperidol results in increased expression of AP2M1 protein

NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140

G

adaptor related protein complex 3 subunit beta 1

increases expression

Haloperidol results in increased expression of AP3B1 protein

NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935

G

apolipoprotein D

increases expression

Haloperidol results in increased expression of APOD mRNA

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of APPL1 protein

NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692

G

activity-regulated cytoskeleton-associated protein

increases expression
multiple interactions

Haloperidol results in increased expression of ARC mRNA
8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of ARC mRNA]

PMID:18208916 PMID:19695244

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

ADP-ribosylation factor 1

decreases expression

Haloperidol results in decreased expression of ARF1 mRNA

NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434

G

ADP-ribosylation factor 3

decreases expression

Haloperidol results in decreased expression of ARF3 mRNA

NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002

G

ADP ribosylation factor like GTPase 3

decreases expression

Haloperidol results in decreased expression of ARL3 mRNA

NCBI chr 1:245,400,659...245,446,673
Ensembl chr 1:245,400,550...245,446,820

G

ADP-ribosylation factor like GTPase 5A

decreases expression

Haloperidol results in decreased expression of ARL5A mRNA

NCBI chr 3:36,878,461...36,903,362
Ensembl chr 3:36,880,712...36,903,211

G

actin related protein 2/3 complex, subunit 4

increases expression

Haloperidol results in increased expression of ARPC4 mRNA

NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

Haloperidol results in decreased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

aspartate-beta-hydroxylase

increases expression

Haloperidol results in increased expression of ASPH protein

NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876

G

ATPase Na+/K+ transporting subunit alpha 1

decreases expression

Haloperidol results in decreased expression of ATP1A1 mRNA

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase Na+/K+ transporting subunit alpha 3

decreases expression

Haloperidol results in decreased expression of ATP1A3 mRNA

NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

Haloperidol results in increased expression of ATP1B1 mRNA

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase Na+/K+ transporting subunit beta 2

decreases expression

Haloperidol results in decreased expression of ATP1B2 mRNA

NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933

G

ATPase Na+/K+ transporting subunit beta 3

increases expression

Haloperidol results in increased expression of ATP1B3 mRNA

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of ATP2A3 protein

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

ATPase H+ transporting V1 subunit B1

decreases expression

Haloperidol results in decreased expression of ATP6V1B1 protein

NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475

G

ATPase H+ transporting V1 subunit B2

decreases expression

Haloperidol results in decreased expression of ATP6V1B2 mRNA

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

axin 2

decreases expression

Haloperidol results in decreased expression of AXIN2 mRNA

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression

Haloperidol results in decreased expression of BAX protein
Haloperidol results in increased expression of BAX mRNA; Haloperidol results in increased expression of BAX protein

PMID:16462815 PMID:17069804

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

branched chain amino acid transaminase 2

decreases expression

Haloperidol results in decreased expression of BCAT2 protein

NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007

G

BCL2, apoptosis regulator

increases expression

Haloperidol results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
increases expression
decreases expression

EPO protein inhibits the reaction [Haloperidol results in decreased expression of BCL2L1 protein]
Haloperidol results in increased expression of BCL2L1 protein

PMID:16462815 PMID:17805306

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

brain-derived neurotrophic factor

multiple interactions
increases expression
decreases expression

BDNF protein inhibits the reaction [Haloperidol results in increased activity of CASP3 protein]; EPO protein inhibits the reaction [Haloperidol results in decreased expression of BDNF protein]; Haloperidol inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]
Haloperidol results in increased expression of BDNF mRNA
Haloperidol results in increased expression of BDNF protein
Haloperidol inhibits the reaction [Cocaine results in decreased expression of BDNF protein]
Haloperidol results in decreased expression of BDNF mRNA; Haloperidol results in decreased expression of BDNF protein

PMID:11488957 PMID:12393228 PMID:12478621 PMID:15168214 PMID:17442543 More...

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

Bet1 golgi vesicular membrane trafficking protein-like

affects expression

Haloperidol affects the expression of BET1L mRNA

NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040

G

BOP1 ribosomal biogenesis factor

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of BOP1 protein

NCBI chr 7:108,172,062...108,195,875
Ensembl chr 7:108,172,066...108,195,931

G

bromodomain PHD finger transcription factor

decreases expression

Haloperidol results in decreased expression of BPTF mRNA

NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769

G

calcium voltage-gated channel subunit alpha1 A

decreases expression

Haloperidol results in decreased expression of CACNA1A mRNA

PMID:14647396 PMID:16715494

NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225

G

calcitonin-related polypeptide alpha

affects activity

Haloperidol affects the activity of CALCA protein

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

calmodulin 2

increases expression

Haloperidol results in increased expression of CALM2 mRNA

NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions
increases expression
decreases expression

Haloperidol results in decreased expression of and results in decreased phosphorylation of CAMK2A protein
Haloperidol results in increased expression of CAMK2A mRNA
Haloperidol results in decreased expression of CAMK2A protein

PMID:15860345 PMID:18061412 PMID:19289156

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

Haloperidol results in decreased expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

Haloperidol results in decreased expression of CAMK2D mRNA

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

G

calcium/calmodulin-dependent protein kinase IV

decreases expression
increases expression

Haloperidol results in decreased expression of CAMK4 protein
Haloperidol results in increased expression of CAMK4 mRNA

PMID:15860345 PMID:19289156

NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487

G

calcium/calmodulin-dependent protein kinase kinase 1

decreases expression

Haloperidol results in decreased expression of CAMKK1 protein

NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498

G

calcium/calmodulin-dependent protein kinase kinase 2

decreases expression

Haloperidol results in decreased expression of CAMKK2 protein

NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279

G

cyclase associated actin cytoskeleton regulatory protein 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of CAP1 protein

NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769

G

caspase 3

multiple interactions
increases expression
increases activity

BDNF protein inhibits the reaction [Haloperidol results in increased activity of CASP3 protein]; EPO protein inhibits the reaction [Haloperidol results in increased expression of CASP3 protein]

PMID:15168214 PMID:17805306 PMID:18590723

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions
decreases activity
decreases expression

Carvedilol inhibits the reaction [Haloperidol results in decreased expression of CAT protein]; Haloperidol results in decreased activity of and results in decreased expression of CAT protein; Zolpidem inhibits the reaction [Haloperidol results in decreased activity of CAT]
Haloperidol results in decreased activity of CAT protein
Cannabidiol inhibits the reaction [Haloperidol results in decreased activity of CAT protein]

PMID:12010767 PMID:12482469 PMID:16564057 PMID:17513028 PMID:30217539

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

chromobox 5

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of CBX5 protein

NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022

G

coiled-coil domain containing 121

increases expression

Haloperidol results in increased expression of CCDC121 protein

NCBI chr 6:24,970,845...24,973,451
Ensembl chr 6:24,970,833...24,973,478

G

cholecystokinin

increases expression

Haloperidol results in increased expression of CCK mRNA

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

cyclin D1

decreases expression

Haloperidol results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

increases expression

Haloperidol results in increased expression of CCND3 mRNA

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin L1

increases expression

Haloperidol results in increased expression of CCNL1 mRNA

NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368

G

chaperonin containing TCP1 subunit 8

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of CCT8 protein

NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079

G

cell division cycle 42

increases expression

Haloperidol results in increased expression of CDC42 mRNA

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

cyclin-dependent kinase 4

increases expression

Haloperidol results in increased expression of CDK4 mRNA

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5

increases expression

Haloperidol results in increased expression of CDK5 mRNA

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

G

cilia and flagella associated protein 161

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of CFAP161 protein

NCBI chr 1:137,743,783...137,768,685
Ensembl chr 1:137,743,784...137,768,730

G

craniofacial development protein 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of CFDP1 protein

NCBI chr19:39,718,313...39,823,824
Ensembl chr19:39,718,347...39,823,824

G

cofilin 1

increases expression

Haloperidol results in increased expression of CFL1 protein

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

cell adhesion molecule L1-like

decreases expression

Haloperidol results in decreased expression of CHL1 mRNA

NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265

G

chimerin 1

decreases expression

Haloperidol results in decreased expression of CHN1 mRNA

NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490

G

cysteine and histidine rich domain containing 1

increases expression

Haloperidol results in increased expression of CHORDC1 protein

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

cholinergic receptor, muscarinic 4

affects response to substance

CHRM4 affects the susceptibility to Haloperidol

NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159

G

claudin 11

decreases expression

Haloperidol results in decreased expression of CLDN11 mRNA

NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050

G

clathrin, light chain A

affects expression

Haloperidol affects the expression of CLTA mRNA

NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472

G

clathrin, light chain B

decreases expression

Haloperidol results in decreased expression of CLTB mRNA

NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169

G

cardiomyopathy associated 5

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of CMYA5 protein

NCBI chr 2:24,279,520...24,378,253
Ensembl chr 2:24,279,528...24,378,364

G

CCR4-NOT transcription complex, subunit 3

decreases expression

Haloperidol results in decreased expression of CNOT3 protein

NCBI chr 1:65,555,924...65,572,167
Ensembl chr 1:65,555,924...65,572,167

G

2',3'-cyclic nucleotide 3' phosphodiesterase

decreases expression

Haloperidol results in decreased expression of CNP mRNA

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

cannabinoid receptor 1

multiple interactions
increases methylation

CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]]; CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]]
Haloperidol results in increased methylation of CNR1 promoter
Haloperidol inhibits the reaction [Methylazoxymethanol Acetate results in decreased methylation of CNR1 promoter]

PMID:28017790 PMID:30496751

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

coilin

increases expression

Haloperidol results in increased expression of COIL mRNA

NCBI chr10:73,789,077...73,810,378
Ensembl chr10:73,789,488...73,810,393

G

COP9 signalosome subunit 3

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of COPS3 protein

NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597

G

COP9 signalosome subunit 4

decreases expression

Haloperidol results in decreased expression of COPS4 protein

NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887

G

carboxypeptidase N subunit 1

increases expression

Haloperidol results in increased expression of CPN1 mRNA

NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465

G

copine 3

decreases expression

Haloperidol results in decreased expression of CPNE3 protein

NCBI chr 5:33,014,658...33,063,934
Ensembl chr 5:33,016,307...33,063,934

G

cAMP responsive element binding protein 1

multiple interactions
increases activity
increases phosphorylation

Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]
Amphetamine affects the reaction [Haloperidol results in increased activity of CREB1 protein modified form]

PMID:12125044 PMID:12871586

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

corticotropin releasing hormone

decreases expression

Haloperidol results in decreased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

corticotropin releasing hormone binding protein

decreases expression

Haloperidol results in decreased expression of CRHBP mRNA

NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710

G

cryptochrome circadian regulator 1

decreases expression

Haloperidol results in decreased expression of CRY1 mRNA

NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091

G

casein kinase 2 alpha 1

decreases expression

Haloperidol results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

cystatin C

increases expression

Haloperidol results in increased expression of CST3 mRNA

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822

G

catenin alpha 1

decreases expression

Haloperidol results in decreased expression of CTNNA1 protein

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

catenin beta 1

decreases expression
increases expression
multiple interactions

Haloperidol results in decreased expression of CTNNB1 mRNA
Haloperidol results in increased expression of CTNNB1 protein
DRD2 protein affects the reaction [Haloperidol results in increased expression of CTNNB1 protein]

PMID:16144542 PMID:18797397

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

chymotrypsin-like

increases expression

Haloperidol results in increased expression of CTRL mRNA

NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626

G

cathepsin K

increases expression

Haloperidol results in increased expression of CTSK mRNA

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cytochrome b5 reductase 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of CYB5R1 protein

NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects response to substance

CYP2D6 protein polymorphism affects the susceptibility to Haloperidol

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol; Fluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]; Fluvoxamine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]; nefazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]; norfluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]; Trazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions

CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol; Fluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; Fluvoxamine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; nefazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; norfluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; Trazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

DDB1 and CUL4 associated factor 6

decreases expression

Haloperidol results in decreased expression of DCAF6 mRNA

NCBI chr13:77,626,257...77,727,645
Ensembl chr13:77,626,307...77,727,512

G

doublecortin-like kinase 1

increases expression

Haloperidol results in increased expression of DCLK1 mRNA

PMID:15860345 PMID:18797397

NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956

G

DEAD-box helicase 27

increases expression

Haloperidol results in increased expression of DDX27 protein

NCBI chr 3:155,744,182...155,763,380
Ensembl chr 3:155,744,150...155,763,372

G

DEAD-box helicase 46

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of DDX46 protein

NCBI chr17:8,942,070...8,988,440
Ensembl chr17:8,944,454...8,988,439

G

DEAD-box helicase 5

decreases expression

Haloperidol results in decreased expression of DDX5 protein

NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283

G

DENN domain containing 10

increases expression

Haloperidol results in increased expression of DENND10 mRNA

NCBI chr 1:259,950,955...259,974,459
Ensembl chr 1:259,950,866...259,974,455

G

DEPP autophagy regulator 1

increases expression

Haloperidol results in increased expression of DEPP1 mRNA

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

diacylglycerol kinase, alpha

decreases expression

Haloperidol results in decreased expression of DGKA mRNA

NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110

G

DEAH-box helicase 36

decreases expression

Haloperidol results in decreased expression of DHX36 protein

NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572

G

DEAH-box helicase 38

decreases expression

Haloperidol results in decreased expression of DHX38 protein

NCBI chr19:37,512,893...37,530,135
Ensembl chr19:37,512,891...37,530,140

G

dihydrolipoamide S-acetyltransferase

decreases expression

Haloperidol results in decreased expression of DLAT mRNA

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479

G

discs large MAGUK scaffold protein 2

increases expression

Haloperidol results in increased expression of DLG2 protein

NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475

G

dynein, axonemal, heavy chain 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of DNAH1 protein

NCBI chr16:6,455,514...6,517,103
Ensembl chr16:6,456,002...6,518,350

G

dynein, axonemal, heavy chain 3

increases expression

Haloperidol results in increased expression of DNAH3 protein

NCBI chr 1:174,305,929...174,479,490
Ensembl chr 1:174,306,644...174,479,474

G

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of DNAJB1 protein

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B11

multiple interactions
increases expression

[Cuprizone co-treated with Haloperidol] results in increased expression of DNAJB11 protein
Haloperidol results in increased expression of DNAJB11 protein

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

double PHD fingers 1

increases expression

Haloperidol results in increased expression of DPF1 mRNA

NCBI chr 1:84,602,212...84,615,954
Ensembl chr 1:84,602,336...84,615,950

G

down-regulator of transcription 1

decreases expression

Haloperidol results in decreased expression of DR1 protein

NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638

G

dopamine receptor D1

affects binding
increases expression
decreases expression
affects activity

Haloperidol binds to DRD1 protein
Haloperidol results in increased expression of DRD1 protein
Haloperidol results in decreased expression of DRD1 mRNA
Haloperidol affects the activity of DRD1 protein

PMID:8750706 PMID:8794996 PMID:12887421 PMID:16983399 PMID:23611293

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

affects binding
affects activity
multiple interactions
increases expression
affects response to substance

DRD2 protein binds to Haloperidol; DRD2 protein binds to Haloperidol analog; Haloperidol binds to DRD2 protein
Haloperidol affects the activity of DRD2 protein
[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; cyclo(leucylglycine) inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein]; felbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein]; Haloperidol binds to and results in decreased activity of DRD2 protein; Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Haloperidol inhibits the reaction [iodosulpride binds to DRD2 protein]; Haloperidol inhibits the reaction [Spiperone binds to DRD2 protein]; Haloperidol promotes the reaction [Dopamine binds to DRD2 protein]; zinc chloride inhibits the reaction [Haloperidol binds to DRD2 protein]
Haloperidol results in increased expression of DRD2; Haloperidol results in increased expression of DRD2 mRNA; Haloperidol results in increased expression of DRD2 protein
Haloperidol binds to DRD2; Haloperidol binds to DRD2 protein; Haloperidol binds to DRD2 protein alternative form
[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Ethanol; [Haloperidol results in increased expression of DRD2 protein] which results in decreased susceptibility to Pentobarbital; Haloperidol binds to and results in decreased activity of DRD2 protein
DRD2 affects the susceptibility to Haloperidol; DRD2 protein affects the susceptibility to Haloperidol
Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]

PMID:1351265 PMID:1361536 PMID:1380082 PMID:2945998 PMID:7845605 More...

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

affects binding
multiple interactions

DRD3 protein binds to Haloperidol analog
Haloperidol affects the reaction [Methylazoxymethanol Acetate results in increased expression of DRD3 mRNA]

PMID:14552778 PMID:32360362

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

affects activity
affects binding

Haloperidol affects the activity of DRD4 protein
Haloperidol binds to Drd4 protein

CTD
RGD

PMID:23611293 PMID:8078498

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

dystrophin related protein 2

increases expression

Haloperidol results in increased expression of DRP2 mRNA alternative form

NCBI chr X:97,607,577...97,658,117
Ensembl chr X:97,607,719...97,655,684

G

dystrobrevin binding protein 1

increases response to substance
affects response to substance

DTNBP1 gene polymorphism results in increased susceptibility to Haloperidol
DTNBP1 protein affects the susceptibility to Haloperidol

NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661

G

dual specificity phosphatase 1

decreases expression

Haloperidol results in decreased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 6

decreases expression

Haloperidol results in decreased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

dishevelled segment polarity protein 3

multiple interactions
increases expression

DRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]

NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462

G

eukaryotic translation elongation factor 1 gamma

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of EEF1G protein

NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382

G

early growth response 1

affects expression
multiple interactions
increases expression

Haloperidol affects the expression of EGR1 protein
Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]; OPRM1 protein inhibits the reaction [Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]]
Haloperidol results in increased expression of EGR1 mRNA; Haloperidol results in increased expression of EGR1 protein

PMID:12243769 PMID:16452686 PMID:17028028 PMID:17913375 PMID:18208916 More...

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

affects expression
increases expression
decreases expression

Haloperidol affects the expression of EGR2 mRNA
Haloperidol results in increased expression of EGR2 mRNA
Haloperidol results in decreased expression of EGR2 protein

PMID:17028028 PMID:18208916 PMID:19401217

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

eukaryotic translation initiation factor 2B subunit epsilon

increases expression

Haloperidol results in increased expression of EIF2B5 protein

NCBI chr11:80,394,433...80,404,468
Ensembl chr11:80,394,433...80,404,419

G

eukaryotic translation initiation factor 5A

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of EIF5A protein

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

ETS transcription factor ELK1

increases phosphorylation
multiple interactions

Haloperidol results in increased phosphorylation of ELK1 protein
Nifedipine affects the reaction [Haloperidol results in increased phosphorylation of ELK1 protein]
SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of ELK1 protein]

PMID:12871586 PMID:17913375

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

enolase 1

increases expression

Haloperidol results in increased expression of ENO1 mRNA

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

erythropoietin

multiple interactions

EPO protein inhibits the reaction [Haloperidol results in decreased expression of BCL2L1 protein]; EPO protein inhibits the reaction [Haloperidol results in decreased expression of BDNF protein]; EPO protein inhibits the reaction [Haloperidol results in increased expression of CASP3 protein]

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

endoplasmic reticulum aminopeptidase 1

decreases expression

Haloperidol results in decreased expression of ERAP1 protein

NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447

G

erb-b2 receptor tyrosine kinase 2

multiple interactions

Haloperidol results in increased expression of and results in increased phosphorylation of ERBB2 protein

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 4

increases expression
multiple interactions

Haloperidol results in increased expression of ERBB4 protein
Haloperidol results in increased expression of and results in increased phosphorylation of ERBB4 protein

PMID:18184445 PMID:26961615

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

endoplasmic reticulum-golgi intermediate compartment 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of ERGIC1 protein

NCBI chr10:16,531,192...16,626,974
Ensembl chr10:16,531,194...16,626,957

G

ezrin

decreases expression

Haloperidol results in decreased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

fatty acid binding protein 3

affects response to substance
increases expression

FABP3 affects the susceptibility to Haloperidol
Haloperidol results in increased expression of FABP3 protein

PMID:20181611 PMID:34122009

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

fatty acid synthase

increases expression

Haloperidol results in increased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

Fms related receptor tyrosine kinase 1

decreases expression

Haloperidol results in decreased expression of FLT1 protein

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

fibronectin type III domain containing 4

increases expression

Haloperidol results in increased expression of FNDC4 mRNA

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
decreases expression

8-Hydroxy-2-(di-n-propylamino)tetralin affects the reaction [Haloperidol results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Haloperidol results in increased expression of FOS protein]; ifenprodil inhibits the reaction [Haloperidol results in increased expression of FOS protein]; tandospirone inhibits the reaction [Haloperidol results in increased expression of FOS protein]; traxoprodil mesylate inhibits the reaction [Haloperidol results in increased expression of FOS protein]; WAY 100135 inhibits the reaction [tandospirone inhibits the reaction [Haloperidol results in increased expression of FOS protein]]
Haloperidol results in increased expression of FOS mRNA; Haloperidol results in increased expression of FOS protein
Haloperidol results in decreased expression of FOS mRNA; Haloperidol results in decreased expression of FOS protein
8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Dronabinol promotes the reaction [Haloperidol results in increased expression of FOS protein]; Nifedipine affects the reaction [Haloperidol results in increased expression of FOS protein]; Nimodipine affects the reaction [Haloperidol results in increased expression of FOS protein]; Propranolol inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Theophylline inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]

PMID:1393566 PMID:9571656 PMID:9748542 PMID:10199625 PMID:10435392 More...

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Haloperidol results in increased expression of FOSB protein alternative form
Haloperidol results in increased expression of FOSB modified form; Haloperidol results in increased expression of FOSB mRNA; Haloperidol results in increased expression of FOSB protein
8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOSB mRNA]

PMID:8714707 PMID:11180499 PMID:12243769 PMID:15579174 PMID:19695244 More...

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions
increases expression

Amphetamine affects the reaction [Haloperidol results in increased expression of FOSL1 protein]
Haloperidol results in increased expression of FOSL1 mRNA; Haloperidol results in increased expression of FOSL1 protein

PMID:12125044 PMID:18208916

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

increases expression

Haloperidol results in increased expression of FOSL2 mRNA

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

FYN proto-oncogene, Src family tyrosine kinase

multiple interactions
increases phosphorylation
affects response to substance

FYN gene mutant form inhibits the reaction [Haloperidol results in increased phosphorylation of GRIN2B protein]
Haloperidol results in increased phosphorylation of FYN protein
FYN protein affects the susceptibility to Haloperidol

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

gamma-aminobutyric acid type A receptor subunit alpha 1

decreases expression

Haloperidol results in decreased expression of GABRA1 mRNA

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 3

increases expression

Haloperidol results in increased expression of GABRB3 mRNA

NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961

G

glutamate decarboxylase 1

multiple interactions
increases expression
decreases expression

[Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein
Haloperidol results in increased expression of GAD1 mRNA
Haloperidol results in decreased expression of GAD1 mRNA; Haloperidol results in decreased expression of GAD1 protein

PMID:12887421 PMID:14519413 PMID:15061247 PMID:15967061 PMID:18923069 More...

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

glutamate decarboxylase 2

decreases expression
increases expression

Haloperidol results in decreased expression of GAD2 mRNA; Haloperidol results in decreased expression of GAD2 protein
Haloperidol results in increased expression of GAD2 mRNA

PMID:18923069 PMID:19359144

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

polypeptide N-acetylgalactosaminyltransferase 2

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of GALNT2 protein

NCBI chr19:52,213,226...52,324,816
Ensembl chr19:52,213,351...52,324,813

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

Haloperidol results in increased expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

guanine deaminase

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of GDA protein

NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

Haloperidol results in increased expression of GDPD3 mRNA

NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063

G

glial fibrillary acidic protein

decreases expression

Haloperidol results in decreased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

GTPase, IMAP family member 5

decreases expression

Haloperidol results in decreased expression of GIMAP5 mRNA

NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086

G

gap junction protein, alpha 1

decreases expression

Haloperidol results in decreased expression of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glyoxalase 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of GLO1 protein

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

glutamate-ammonia ligase

decreases expression

Haloperidol results in decreased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

G protein subunit alpha 12

decreases expression

Haloperidol results in decreased expression of GNA12 mRNA

NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255

G

G protein subunit alpha i1

decreases expression

Haloperidol results in decreased expression of GNAI1 mRNA

NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417

G

G protein subunit alpha i2

decreases expression

Haloperidol results in decreased expression of GNAI2 mRNA

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

G protein subunit alpha i3

decreases expression

Haloperidol results in decreased expression of GNAI3 mRNA

NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742

G

G protein subunit alpha o1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of GNAO1 protein

NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493

G

GNAS complex locus

decreases expression

Haloperidol results in decreased expression of GNAS mRNA

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

gonadotropin releasing hormone 1

multiple interactions

Haloperidol inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

glutamic-oxaloacetic transaminase 2

affects expression
multiple interactions

Haloperidol affects the expression of GOT2 mRNA
[Cuprizone co-treated with Haloperidol] results in increased expression of GOT2 protein

PMID:15860345 PMID:34122009

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glutathione peroxidase 1

increases expression

Haloperidol results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutamate ionotropic receptor AMPA type subunit 1

decreases expression

Haloperidol results in decreased expression of GRIA1 mRNA

NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283

G

glutamate ionotropic receptor kainate type subunit 2

increases expression

Haloperidol results in increased expression of GRIK2 mRNA

NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375

G

glutamate ionotropic receptor kainate type subunit 4

increases expression

Haloperidol results in increased expression of GRIK4 mRNA

NCBI chr 8:42,903,043...43,331,990
Ensembl chr 8:42,905,056...43,193,751

G

glutamate ionotropic receptor kainate type subunit 5

increases expression

Haloperidol results in increased expression of GRIK5 mRNA

PMID:14647396 PMID:15860345

NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression
increases expression

Haloperidol results in decreased expression of GRIN1 mRNA
Haloperidol results in increased expression of GRIN1 mRNA

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

Haloperidol results in decreased expression of GRIN2A mRNA; Haloperidol results in decreased expression of GRIN2A protein

PMID:12608697 PMID:15860345 PMID:18061412

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions
increases phosphorylation

FYN gene mutant form inhibits the reaction [Haloperidol results in increased phosphorylation of GRIN2B protein]

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glutamate ionotropic receptor NMDA type subunit 2C

increases expression

Haloperidol results in increased expression of GRIN2C mRNA

NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427

G

glutamate ionotropic receptor NMDA type subunit 2D

decreases expression

Haloperidol results in decreased expression of GRIN2D mRNA

NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793

G

glutamate ionotropic receptor NMDA type subunit 3B

increases expression

Haloperidol results in increased expression of GRIN3B mRNA

NCBI chr 7:9,730,861...9,737,183
Ensembl chr 7:9,730,862...9,737,183

G

G protein-coupled receptor kinase 6

decreases expression

Haloperidol results in decreased expression of GRK6 mRNA

NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644

G

glutamate metabotropic receptor 1

increases expression

Haloperidol results in increased expression of GRM1 mRNA

NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170

G

glutamate metabotropic receptor 2

increases expression

Haloperidol results in increased expression of GRM2 mRNA

NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146

G

glycogen synthase kinase 3 alpha

increases expression
multiple interactions

Haloperidol results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3A protein]

NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802

G

glycogen synthase kinase 3 beta

multiple interactions
increases expression

DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein]
Haloperidol results in increased expression of GSK3B mRNA; Haloperidol results in increased expression of GSK3B protein

PMID:16144542 PMID:19359144

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase mu 1

increases expression

Haloperidol results in increased expression of GSTM1 mRNA

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

decreases expression

Haloperidol results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

multiple interactions
decreases expression

Haloperidol inhibits the reaction [GSTP1 protein results in decreased susceptibility to Doxorubicin]
Haloperidol results in decreased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

general transcription factor IIE subunit 1

decreases expression

Haloperidol results in decreased expression of GTF2E1 protein

NCBI chr11:63,182,073...63,215,349
Ensembl chr11:63,182,349...63,213,942

G

H2A clustered histone 18

increases expression

Haloperidol results in increased expression of H2AC18 mRNA

NCBI chr 2:183,808,398...183,808,992

G

H2A clustered histone 20

increases expression

Haloperidol results in increased expression of H2AC20 protein

NCBI chr 2:183,779,879...183,780,357

G

H2A.J histone

increases expression

Haloperidol results in increased expression of H2AJ protein

NCBI chr 4:169,675,718...169,676,202
Ensembl chr 4:169,675,752...169,677,006

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of HADHB protein

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

histidyl-tRNA synthetase 1

increases expression

Haloperidol results in increased expression of HARS1 protein

NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740

G

host cell factor C1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of HCFC1 protein

NCBI chr X:151,687,779...151,712,688
Ensembl chr X:151,687,779...151,712,638

G

HIG1 hypoxia inducible domain family, member 1A

increases expression

Haloperidol results in increased expression of HIGD1A mRNA

NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases activity
increases expression
multiple interactions

Haloperidol results in increased activity of HMGCR protein
Haloperidol results in increased expression of HMGCR mRNA
[Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides

PMID:16027736 PMID:17052361

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Haloperidol results in increased expression of HMGCS1 mRNA

PMID:16027736 PMID:17052361

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

heterogeneous nuclear ribonucleoprotein C

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of HNRNPC protein

NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183

G

heterogeneous nuclear ribonucleoprotein K

decreases expression

Haloperidol results in decreased expression of HNRNPK protein

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

homer scaffold protein 1

multiple interactions
increases expression

Cycloserine inhibits the reaction [Haloperidol results in increased expression of HOMER1 mRNA]

PMID:12464447 PMID:15860345 PMID:20147574

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

hippocalcin-like 4

decreases expression

Haloperidol results in decreased expression of HPCAL4 mRNA

NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416

G

hydroxysteroid (17-beta) dehydrogenase 4

decreases expression

Haloperidol results in decreased expression of HSD17B4 protein

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

heparan sulfate proteoglycan 2

decreases expression
multiple interactions

Haloperidol results in decreased expression of HSPG2 mRNA
HSPG2 gene results in increased susceptibility to [Haloperidol co-treated with Reserpine]

NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594

G

heat shock protein family H (Hsp110) member 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of HSPH1 protein

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

5-hydroxytryptamine receptor 1D

decreases expression

Haloperidol results in decreased expression of HTR1D mRNA

NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619

G

5-hydroxytryptamine receptor 2A

affects binding
multiple interactions

Haloperidol binds to HTR2A protein
[Phencyclidine co-treated with Haloperidol] affects the activity of HTR2A protein

PMID:7520908 PMID:12191584 PMID:15380371

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

5-hydroxytryptamine receptor 2C

decreases expression

Haloperidol results in decreased expression of HTR2C mRNA

NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287

G

inhibitor of DNA binding 2

decreases expression
increases expression

Haloperidol results in decreased expression of ID2 mRNA
Haloperidol results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

IKBKB interacting protein

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of IKBIP protein

NCBI chr 7:25,579,865...25,598,548
Ensembl chr 7:25,579,832...25,605,162

G

interleukin 10

multiple interactions

[Cannabidiol co-treated with Haloperidol] results in increased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions
increases expression

Cannabidiol inhibits the reaction [Haloperidol results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression
multiple interactions

Haloperidol results in increased expression of IL6 mRNA
Cannabidiol inhibits the reaction [Haloperidol results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

ILK associated serine/threonine phosphatase

decreases expression

Haloperidol results in decreased expression of ILKAP mRNA

NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892

G

inosine monophosphate dehydrogenase 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of IMPDH1 protein

NCBI chr 4:57,801,842...57,817,434
Ensembl chr 4:57,801,831...57,819,076

G

inhibin subunit alpha

decreases expression

Haloperidol results in decreased expression of INHA mRNA

NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248

G

inhibin subunit beta E

increases expression

Haloperidol results in increased expression of INHBE mRNA

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
decreases expression

Haloperidol results in increased expression of JUN mRNA; Haloperidol results in increased expression of JUN protein
Haloperidol results in decreased expression of JUN mRNA

PMID:12093589 PMID:12125044 PMID:15860345 PMID:18208916

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
decreases expression

8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of JUNB mRNA]
Haloperidol results in decreased expression of JUNB mRNA

PMID:12093589 PMID:19695244

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

potassium voltage-gated channel subfamily A member 1

increases expression

Haloperidol results in increased expression of KCNA1 mRNA; Haloperidol results in increased expression of KCNA1 protein

NCBI chr 4:159,464,223...159,472,905
Ensembl chr 4:159,464,188...159,472,682

G

potassium voltage-gated channel subfamily A regulatory beta subunit 1

decreases expression

Haloperidol results in decreased expression of KCNAB1 mRNA

NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

Haloperidol inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Haloperidol results in decreased activity of KCNH2 protein

PMID:15671647 PMID:16278312 PMID:16494862 PMID:19583963 PMID:21158687

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium voltage-gated channel interacting protein 3

decreases expression

Haloperidol results in decreased expression of KCNIP3 mRNA; Haloperidol results in decreased expression of KCNIP3 protein

NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556

G

lysine demethylase 1A

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of KDM1A protein

NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319

G

kinase insert domain receptor

increases expression

Haloperidol results in increased expression of KDR protein

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

kinesin family member 5C

decreases expression

Haloperidol results in decreased expression of KIF5C protein

NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413

G

kizuna centrosomal protein

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of KIZ protein

NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190

G

kinesin light chain 1

decreases expression

Haloperidol results in decreased expression of KLC1 mRNA

NCBI chr 6:130,823,416...130,866,729
Ensembl chr 6:130,823,419...130,867,031

G

kinesin light chain 4

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of KLC4 protein

NCBI chr 9:14,337,164...14,351,075
Ensembl chr 9:14,337,534...14,351,066

G

kelch domain containing 2

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of KLHDC2 protein

NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187

G

lysine methyltransferase 2A

decreases expression

Haloperidol results in decreased expression of KMT2A mRNA

NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181

G

karyopherin subunit alpha 4

increases expression

Haloperidol results in increased expression of KPNA4 protein

NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081

G

KRAS proto-oncogene, GTPase

increases expression

Haloperidol results in increased expression of KRAS mRNA

NCBI chr 4:178,185,418...178,218,484

G

kringle containing transmembrane protein 1

multiple interactions
increases expression

[Cuprizone co-treated with Haloperidol] results in decreased expression of KREMEN1 protein
Haloperidol results in increased expression of KREMEN1 protein

NCBI chr14:80,081,870...80,147,489
Ensembl chr14:80,084,403...80,147,516

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

increases expression

Haloperidol results in increased expression of LAMTOR3 mRNA

NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607

G

lactate dehydrogenase B

decreases expression
increases expression

Haloperidol results in decreased expression of LDHB mRNA
Haloperidol results in increased expression of LDHB mRNA

PMID:15860345 PMID:16465460

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

low density lipoprotein receptor

increases expression

Haloperidol results in increased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

galectin 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of LGALS1 protein

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

lipase A, lysosomal acid type

increases expression

Haloperidol results in increased expression of LIPA protein

NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633

G

myelin-associated glycoprotein

decreases expression

Haloperidol results in decreased expression of MAG mRNA

NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656

G

microtubule-associated protein 1A

increases expression
decreases expression

Haloperidol results in increased expression of MAP1A mRNA
Haloperidol results in decreased expression of MAP1A protein

PMID:15860345 PMID:34122009

NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899

G

microtubule-associated protein 2

increases expression

Haloperidol results in increased expression of MAP2 mRNA

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase kinase 1

decreases expression

Haloperidol results in decreased expression of MAP2K1 mRNA

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

decreases expression
increases expression

Haloperidol results in decreased expression of MAP2K2 mRNA
Haloperidol results in increased expression of MAP2K2 mRNA

PMID:14647396 PMID:15860345

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase kinase 5

decreases expression

Haloperidol results in decreased expression of MAP2K5 mRNA

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983

G

mitogen-activated protein kinase kinase kinase 1

increases expression

Haloperidol results in increased expression of MAP3K1 mRNA

NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463

G

mitogen activated protein kinase kinase kinase 12

increases expression

Haloperidol results in increased expression of MAP3K12 mRNA

NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789

G

mitogen activated protein kinase 1

increases phosphorylation
decreases expression
multiple interactions

Haloperidol results in increased phosphorylation of MAPK1 protein
Haloperidol results in decreased expression of MAPK1 mRNA
[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]; Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]; CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]

PMID:12871586 PMID:15860345 PMID:28017790

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

affects expression

Haloperidol affects the expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Haloperidol results in increased phosphorylation of MAPK3 protein
[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]; Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]; CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]

PMID:12871586 PMID:28017790

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 6

affects expression

Haloperidol affects the expression of MAPK6 mRNA

NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720

G

mitogen-activated protein kinase 8

increases phosphorylation

Haloperidol results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

affects expression

Haloperidol affects the expression of MAPK9 mRNA

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microtubule-associated protein, RP/EB family, member 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of MAPRE1 protein

NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983

G

MAS1 proto-oncogene, G protein-coupled receptor

decreases expression

Haloperidol results in decreased expression of MAS1 mRNA

NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709

G

myelin basic protein

decreases expression

Haloperidol results in decreased expression of MBP mRNA

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

melanoma cell adhesion molecule

increases expression

Haloperidol results in increased expression of MCAM protein

NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571

G

melanin-concentrating hormone receptor 1

affects binding

Haloperidol binds to MCHR1 protein

NCBI chr 7:112,761,554...112,764,746
Ensembl chr 7:112,761,554...112,764,032

G

matrix metallopeptidase 10

decreases expression

Haloperidol results in decreased expression of MMP10 protein

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

myelin oligodendrocyte glycoprotein

decreases expression

Haloperidol results in decreased expression of MOG mRNA

NCBI chr20:1,513,137...1,523,473
Ensembl chr20:1,513,239...1,523,474

G

mitochondrial ribosomal protein S31

increases expression

Haloperidol results in increased expression of MRPS31 protein

NCBI chr16:69,601,349...69,621,609
Ensembl chr16:69,601,349...69,630,654

G

myeloid-associated differentiation marker

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of MYADM protein

NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035

G

myosin Vb

decreases expression

Haloperidol results in decreased expression of MYO5B protein

NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745

G

nucleosome assembly protein 1-like 3

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of NAP1L3 protein

NCBI chr X:88,347,595...88,350,393
Ensembl chr X:88,347,598...88,350,393

G

neurocan

decreases expression

Haloperidol results in decreased expression of NCAN mRNA

NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436

G

non-SMC condensin I complex, subunit H

decreases expression

Haloperidol results in decreased expression of NCAPH protein

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

nucleolin

increases expression

Haloperidol results in increased expression of NCL mRNA

NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136

G

NADH:ubiquinone oxidoreductase core subunit V1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of NDUFV1 protein

NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466

G

NEDD4 E3 ubiquitin protein ligase

decreases expression

Haloperidol results in decreased expression of NEDD4 mRNA

NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951

G

nuclear factor kappa B subunit 1

decreases expression

Haloperidol results in decreased expression of NFKB1 protein

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nerve growth factor receptor

decreases expression

Haloperidol results in decreased expression of NGFR mRNA

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

nucleolar protein interacting with the FHA domain of MKI67

decreases expression

Haloperidol results in decreased expression of NIFK protein

NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896

G

NOP14 nucleolar protein

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of NOP14 protein

NCBI chr14:76,081,313...76,102,454
Ensembl chr14:76,080,793...76,102,453

G

NOP53 ribosome biogenesis factor

increases expression

Haloperidol results in increased expression of NOP53 mRNA

NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902

G

nitric oxide synthase 2

multiple interactions
increases expression

Cannabidiol inhibits the reaction [Haloperidol results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

natriuretic peptide A

affects activity

Haloperidol affects the activity of NPPA protein modified form

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

neuronal pentraxin 2

decreases expression

Haloperidol results in decreased expression of NPTX2 mRNA

NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345

G

neuropeptide Y

multiple interactions
increases expression
decreases expression

Haloperidol promotes the reaction [Amphetamine results in decreased expression of NPY protein]
Haloperidol results in increased expression of NPY protein
Haloperidol results in decreased expression of NPY mRNA

PMID:7644023 PMID:15985714 PMID:16516965

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Haloperidol results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group D, member 1

increases expression

Haloperidol results in increased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 4, group A, member 1

affects response to substance
multiple interactions
increases expression
decreases expression

NR4A1 affects the susceptibility to Haloperidol
8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of NR4A1 mRNA]
Haloperidol results in decreased expression of NR4A1 mRNA

PMID:10987852 PMID:11564422 PMID:14603264 PMID:19695244

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 3

increases expression

Haloperidol results in increased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

neuregulin 1

increases expression

Haloperidol results in increased expression of NRG1 protein

PMID:18184445 PMID:26961615

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

Haloperidol results in decreased expression of NSF mRNA
Haloperidol results in decreased expression of NSF protein

PMID:15860345 PMID:34122009

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

neurotensin

multiple interactions
increases expression

SLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA]
Haloperidol results in increased expression of NTS mRNA; Haloperidol results in increased expression of NTS protein
8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]; Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]

PMID:10199625 PMID:11120399 PMID:11602683 PMID:12887421 PMID:14603264 More...

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

NUMB-like, endocytic adaptor protein

decreases expression

Haloperidol results in decreased expression of NUMBL mRNA

NCBI chr 1:82,549,814...82,573,788
Ensembl chr 1:82,550,054...82,573,776

G

nucleoporin 54

decreases expression

Haloperidol results in decreased expression of NUP54 protein

NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028

G

nuclear protein 1, transcriptional regulator

increases expression

Haloperidol results in increased expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

ornithine aminotransferase

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of OAT protein

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

opioid related nociceptin receptor 1

affects response to substance

OPRL1 affects the susceptibility to Haloperidol

NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920

G

opioid receptor, mu 1

multiple interactions

OPRM1 protein inhibits the reaction [Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]]

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

oxysterol binding protein-like 8

increases expression

Haloperidol results in increased expression of OSBPL8 mRNA

NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888

G

Parkinsonism associated deglycase

increases expression

Haloperidol results in increased expression of PARK7 mRNA

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

decreases expression

Haloperidol results in decreased expression of PCMT1 protein

NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201

G

proprotein convertase subtilisin/kexin type 1 inhibitor

increases expression

Haloperidol results in increased expression of PCSK1N mRNA

NCBI chr X:14,580,036...14,583,478
Ensembl chr X:14,580,038...14,583,566

G

phosphodiesterase 10A

increases expression

Haloperidol results in increased expression of PDE10A mRNA; Haloperidol results in increased expression of PDE10A protein

NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563

G

phosphodiesterase 1B

increases expression

Haloperidol results in increased expression of PDE1B mRNA; Haloperidol results in increased expression of PDE1B protein

PMID:14647396 PMID:18222493

NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580

G

phosphodiesterase 4A

decreases expression

Haloperidol results in decreased expression of PDE4A protein

NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961

G

PDZ and LIM domain 5

decreases expression

Haloperidol results in decreased expression of PDLIM5 protein

NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275

G

PDZ domain containing RING finger 3

decreases expression

Haloperidol results in decreased expression of PDZRN3 protein

NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959

G

proenkephalin

multiple interactions
increases expression

3,4-dicarboxyphenylglycine promotes the reaction [Haloperidol results in increased expression of PENK mRNA]; Docosahexaenoic Acids inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; Tretinoin inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]
Haloperidol results in increased expression of PENK mRNA; Haloperidol results in increased expression of PENK protein
1-aminocyclopentane-1,2,4-tricarboxylic acid inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; 1-aminoindan-1,5-dicarboxylic acid inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; 2-(2,3-dicarboxycyclopropyl)glycine promotes the reaction [Haloperidol results in increased expression of PENK mRNA]; 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; Memantine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]

PMID:3838946 PMID:7637876 PMID:12373537 PMID:12727308 PMID:12834887 More...

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

period circadian regulator 1

increases expression

Haloperidol results in increased expression of PER1 mRNA

NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431

G

prefoldin subunit 5

increases expression

Haloperidol results in increased expression of PFDN5 mRNA

NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516

G

phosphofructokinase, platelet

increases expression
multiple interactions

Haloperidol results in increased expression of PFKP mRNA
[Cuprizone co-treated with Haloperidol] results in increased expression of PFKP protein

PMID:15860345 PMID:34122009

NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018

G

profilin 1

increases expression

Haloperidol results in increased expression of PFN1 protein

NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631

G

phosphoglycerate kinase 1

increases expression

Haloperidol results in increased expression of PGK1 mRNA

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

phosphatase and actin regulator 1

increases expression

Haloperidol results in increased expression of PHACTR1 mRNA

NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831

G

phosphatidylinositol binding clathrin assembly protein

decreases expression

Haloperidol results in decreased expression of PICALM mRNA

NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557

G

phosphoinositide-3-kinase regulatory subunit 3

decreases expression

Haloperidol results in decreased expression of PIK3R3 mRNA

NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583

G

cAMP-dependent protein kinase inhibitor beta

decreases expression

Haloperidol results in decreased expression of PKIB mRNA

NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187

G

pyruvate kinase M1/2

increases expression

Haloperidol results in increased expression of PKM mRNA

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

proteolipid protein 1

decreases expression

Haloperidol results in decreased expression of PLP1 mRNA

PMID:17177202 PMID:18797397

NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032

G

pyridoxal phosphate binding protein

increases expression

Haloperidol results in increased expression of PLPBP protein

NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886

G

plastin 3

decreases expression

Haloperidol results in decreased expression of PLS3 protein

NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891

G

peptidase, mitochondrial processing subunit alpha

increases expression

Haloperidol results in increased expression of PMPCA protein

NCBI chr 3:9,207,731...9,216,846
Ensembl chr 3:9,207,717...9,216,844

G

inorganic pyrophosphatase 1

increases expression

Haloperidol results in increased expression of PPA1 protein

NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215

G

PPARG coactivator 1 alpha

multiple interactions

[Cannabidiol co-treated with Haloperidol] results in increased expression of PPARGC1A protein

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein phosphatase, Mg2+/Mn2+ dependent, 1A

decreases expression

Haloperidol results in decreased expression of PPM1A mRNA

NCBI chr 6:91,439,094...91,486,139
Ensembl chr 6:91,438,834...91,480,697

G

protein phosphatase, Mg2+/Mn2+ dependent, 1B

decreases expression

Haloperidol results in decreased expression of PPM1B mRNA

NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974

G

protein phosphatase, Mg2+/Mn2+ dependent, 1F

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of PPM1F protein

NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340

G

protein phosphatase 1 catalytic subunit beta

decreases expression

Haloperidol results in decreased expression of PPP1CB mRNA

NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824

G

protein phosphatase 1 catalytic subunit gamma

decreases expression

Haloperidol results in decreased expression of PPP1CC mRNA

NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553

G

protein phosphatase 1, regulatory (inhibitor) subunit 14B

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of PPP1R14B protein

NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319

G

protein phosphatase 1, regulatory (inhibitor) subunit 1A

decreases expression

Haloperidol results in decreased expression of PPP1R1A mRNA

NCBI chr 7:134,654,578...134,662,236
Ensembl chr 7:134,654,579...134,662,230

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

increases phosphorylation

Haloperidol results in increased phosphorylation of PPP1R1B protein

NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775

G

protein phosphatase 1, regulatory (inhibitor) subunit 2

decreases expression

Haloperidol results in decreased expression of PPP1R2 mRNA

NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463

G

protein phosphatase 1, regulatory subunit 9B

decreases expression

Haloperidol results in decreased expression of PPP1R9B protein

NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083

G

protein phosphatase 2 catalytic subunit alpha

decreases expression

Haloperidol results in decreased expression of PPP2CA mRNA

NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862

G

protein phosphatase 2 catalytic subunit beta

decreases expression

Haloperidol results in decreased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

protein phosphatase 2 scaffold subunit A alpha

increases expression

Haloperidol results in increased expression of PPP2R1A mRNA

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

G

protein phosphatase 2, regulatory subunit B, alpha

decreases expression

Haloperidol results in decreased expression of PPP2R2A mRNA

NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924

G

protein phosphatase 3 catalytic subunit alpha

multiple interactions
decreases expression

[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Haloperidol results in decreased expression of PPP3CA mRNA; Haloperidol results in decreased expression of PPP3CA protein

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

protein phosphatase 5, catalytic subunit

decreases expression
multiple interactions

Haloperidol results in decreased expression of PPP5C mRNA
[Cuprizone co-treated with Haloperidol] results in decreased expression of PPP5C protein

PMID:14647396 PMID:34122009

NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456

G

protein kinase cAMP-activated catalytic subunit alpha

increases expression

Haloperidol results in increased expression of PRKACA mRNA

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

G

protein kinase cAMP-activated catalytic subunit beta

increases expression

Haloperidol results in increased expression of PRKACB mRNA

NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198

G

protein kinase cAMP-dependent type II regulatory subunit alpha

multiple interactions
increases expression

Haloperidol promotes the reaction [Cyclic AMP binds to PRKAR2A protein]
[Cuprizone co-treated with Haloperidol] results in decreased expression of PRKAR2A protein
Haloperidol results in increased expression of PRKAR2A mRNA; Haloperidol results in increased expression of PRKAR2A protein

PMID:11907174 PMID:34122009

NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628

G

protein kinase cAMP-dependent type II regulatory subunit beta

multiple interactions
increases expression
decreases expression

Haloperidol promotes the reaction [Cyclic AMP binds to PRKAR2B protein]
Haloperidol results in increased expression of PRKAR2B mRNA; Haloperidol results in increased expression of PRKAR2B protein
Haloperidol results in decreased expression of PRKAR2B mRNA

PMID:11907174 PMID:15860345

NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933

G

protein kinase C, beta

multiple interactions
increases expression

[Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB protein
Haloperidol results in increased expression of PRKCB mRNA

PMID:15860345 PMID:15967061

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, epsilon

increases expression

Haloperidol results in increased expression of PRKCE mRNA

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

PRKCSH beta subunit of glucosidase II

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of PRKCSH protein

NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492

G

protein kinase C, zeta

increases expression

Haloperidol results in increased expression of PRKCZ mRNA

NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367

G

prolactin

affects expression
increases secretion
multiple interactions
increases expression

Haloperidol affects the expression of PRL protein
Haloperidol results in increased secretion of PRL protein
Haloperidol inhibits the reaction [Aripiprazole results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [cabergoline results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Dopamine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [talipexole results in decreased secretion of PRL protein]; LHRH, N-acetyl-(4-chlorophenylalanyl)(1)-(4-chlorophenylalanyl)(2)-tryptophyl(3)-arginyl(6)-alanine(10)- inhibits the reaction [Haloperidol results in increased expression of PRL protein]; Triptorelin Pamoate inhibits the reaction [Haloperidol results in increased expression of PRL protein]

PMID:1304992 PMID:1380082 PMID:2136057 PMID:3019639 PMID:3158510 More...

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

pre-mRNA processing factor 19

increases expression

Haloperidol results in increased expression of PRPF19 protein

NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662

G

pre-mRNA processing factor 38B

decreases expression

Haloperidol results in decreased expression of PRPF38B mRNA

NCBI chr 2:196,553,224...196,562,271
Ensembl chr 2:196,553,225...196,562,250

G

proline-rich coiled-coil 2A

decreases expression

Haloperidol results in decreased expression of PRRC2A mRNA

NCBI chr20:3,658,391...3,674,143
Ensembl chr20:3,658,695...3,674,130

G

peroxiredoxin like 2A

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of PRXL2A protein

NCBI chr16:16,866,601...16,886,378
Ensembl chr16:16,866,603...16,886,433

G

proteasome 20S subunit beta 9

decreases expression

Haloperidol results in decreased expression of PSMB9 mRNA

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

G

proteasome 26S subunit, non-ATPase 12

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of PSMD12 protein

NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287

G

prostaglandin-endoperoxide synthase 2

increases expression

Haloperidol results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

prothymosin alpha

increases expression

Haloperidol results in increased expression of PTMA protein

NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333

G

parathymosin

increases expression

Haloperidol results in increased expression of PTMS mRNA

NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009

G

purine rich element binding protein A

increases expression

Haloperidol results in increased expression of PURA protein

NCBI chr18:27,885,071...27,905,509
Ensembl chr18:27,884,556...27,905,513

G

purine rich element binding protein B

decreases expression

Haloperidol results in decreased expression of PURB protein

NCBI chr14:81,342,374...81,344,857
Ensembl chr14:81,336,448...81,351,432

G

parvalbumin

multiple interactions

Haloperidol inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA]

NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561

G

pyrroline-5-carboxylate reductase 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of PYCR1 protein

NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549

G

glycogen phosphorylase, muscle associated

decreases expression

Haloperidol results in decreased expression of PYGM protein

NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368

G

QKI, KH domain containing RNA binding

increases expression

Haloperidol results in increased expression of QKI mRNA alternative form

NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831

G

RAB10, member RAS oncogene family

increases expression

Haloperidol results in increased expression of RAB10 mRNA

NCBI chr 6:26,267,081...26,319,739
Ensembl chr 6:26,266,859...26,320,193

G

RAB11a, member RAS oncogene family

increases expression

Haloperidol results in increased expression of RAB11A mRNA

NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525

G

RAB12, member RAS oncogene family

increases expression

Haloperidol results in increased expression of RAB12 mRNA

NCBI chr 9:106,480,301...106,506,895
Ensembl chr 9:106,480,301...106,506,910

G

RAB28, member RAS oncogene family

increases expression

Haloperidol results in increased expression of RAB28 mRNA

NCBI chr14:69,245,846...69,322,968
Ensembl chr14:69,245,854...69,322,967

G

RAB4A, member RAS oncogene family

decreases expression

Haloperidol results in decreased expression of RAB4A mRNA

NCBI chr19:51,795,613...51,822,706
Ensembl chr19:51,795,613...51,822,703

G

RAB5A, member RAS oncogene family

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of RAB5A protein

NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873

G

RAB6A, member RAS oncogene family

increases expression

Haloperidol results in increased expression of RAB6A mRNA

NCBI chr 1:154,957,870...155,008,922
Ensembl chr 1:154,958,189...154,996,715

G

RAB7A, member RAS oncogene family

decreases expression

Haloperidol results in decreased expression of RAB7A mRNA

NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889

G

RAB8A, member RAS oncogene family

decreases expression

Haloperidol results in decreased expression of RAB8A mRNA

NCBI chr16:17,654,027...17,675,385
Ensembl chr16:17,654,034...17,675,678

G

Rac family small GTPase 1

increases expression

Haloperidol results in increased expression of RAC1 mRNA

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

RAS like proto-oncogene A

increases expression

Haloperidol results in increased expression of RALA mRNA

NCBI chr17:47,092,163...47,145,192
Ensembl chr17:47,092,207...47,144,063

G

RAS like proto-oncogene B

increases expression

Haloperidol results in increased expression of RALB mRNA

NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202

G

RAN binding protein 3

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of RANBP3 protein

NCBI chr 9:1,507,233...1,544,460
Ensembl chr 9:1,507,361...1,544,460

G

RAP1B, member of RAS oncogene family

increases expression

Haloperidol results in increased expression of RAP1B mRNA

NCBI chr 7:53,423,039...53,456,349
Ensembl chr 7:53,423,130...53,456,370

G

Rap guanine nucleotide exchange factor 4

decreases expression

Haloperidol results in decreased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

retinoic acid receptor, beta

increases expression

Haloperidol results in increased expression of RARB mRNA alternative form

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

RAS protein-specific guanine nucleotide-releasing factor 1

affects localization

Haloperidol affects the localization of RASGRF1 protein

NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269

G

RAS guanyl releasing protein 1

decreases expression

Haloperidol results in decreased expression of RASGRP1 mRNA

NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056

G

reticulocalbin 1

multiple interactions
decreases expression

[Cuprizone co-treated with Haloperidol] results in increased expression of RCN1 protein
Haloperidol results in decreased expression of RCN1 protein

NCBI chr 3:91,841,052...91,855,295
Ensembl chr 3:91,841,052...91,855,295

G

retinol dehydrogenase 11

decreases expression

Haloperidol results in decreased expression of RDH11 protein

NCBI chr 6:97,979,377...97,995,252
Ensembl chr 6:97,979,378...97,995,252

G

radixin

decreases expression

Haloperidol results in decreased expression of RDX protein

NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678

G

RELA proto-oncogene, NF-kB subunit

increases expression

Haloperidol results in increased expression of RELA protein

PMID:18554768 PMID:18590723

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

reelin

decreases expression

Haloperidol results in decreased expression of RELN mRNA; Haloperidol results in decreased expression of RELN protein

NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211

G

regulator of G-protein signaling 2

increases expression

Haloperidol results in increased expression of RGS2 mRNA

PMID:11409749 PMID:11516571

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

regulator of G-protein signaling 4

increases expression

Haloperidol results in increased expression of RGS4 mRNA

NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068

G

regulator of G-protein signaling 8

increases expression

Haloperidol results in increased expression of RGS8 mRNA

NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807

G

regulator of G-protein signaling 9

affects response to substance

RGS9 affects the susceptibility to Haloperidol

NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892

G

ras homolog family member A

decreases expression

Haloperidol results in decreased expression of RHOA mRNA

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

regulating synaptic membrane exocytosis 1

decreases expression

Haloperidol results in decreased expression of RIMS1 mRNA

NCBI chr 9:24,696,959...25,196,404
Ensembl chr 9:24,698,854...25,196,631

G

RAR-related orphan receptor B

decreases expression

Haloperidol results in decreased expression of RORB mRNA

NCBI chr 1:216,363,629...216,544,390
Ensembl chr 1:216,363,629...216,544,390

G

ribosomal protein L13

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of RPL13 protein

NCBI chr19:51,153,990...51,156,541
Ensembl chr19:51,153,924...51,163,014

G

ribosomal protein L18A

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of RPL18A protein

NCBI chr16:18,542,555...18,544,578
Ensembl chr16:18,542,566...18,545,546

G

ribosomal protein L19

decreases expression
multiple interactions

Haloperidol results in decreased expression of RPL19 protein
[Cuprizone co-treated with Haloperidol] results in increased expression of RPL19 protein

NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112

G

ribosomal protein L30

increases expression

Haloperidol results in increased expression of RPL30 protein

NCBI chr 7:65,648,266...65,651,401
Ensembl chr 7:65,645,991...65,651,363
Ensembl chr10:65,645,991...65,651,363
Ensembl chr10:65,645,991...65,651,363

G

ribosomal protein L6

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of RPL6 protein

NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921

G

ribosomal protein L8

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of RPL8 protein

NCBI chr 7:108,626,194...108,628,485
Ensembl chr 7:108,622,324...108,628,482
Ensembl chr 3:108,622,324...108,628,482

G

ribosomal protein lateral stalk subunit P0 like 1

decreases expression

Haloperidol results in decreased expression of RPLP0P6 protein

NCBI chr 2:191,921,503...191,922,661
Ensembl chr 2:191,921,574...191,922,646

G

ribosomal protein lateral stalk subunit P2

increases expression

Haloperidol results in increased expression of RPLP2 mRNA

NCBI chr 1:196,546,086...196,548,636
Ensembl chr 1:196,546,352...196,548,645

G

ribosomal protein S10

increases expression

Haloperidol results in increased expression of RPS10 mRNA

NCBI chr20:5,694,313...5,698,922
Ensembl chr20:5,694,313...5,699,044
Ensembl chr 6:5,694,313...5,699,044

G

ribosomal protein S16

decreases expression

Haloperidol results in decreased expression of RPS16 protein

NCBI chr 1:83,643,066...83,646,056
Ensembl chr 1:83,643,130...83,646,206

G

ribosomal protein S27

increases expression

Haloperidol results in increased expression of RPS27 protein

NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964

G

ribosomal protein S27a

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of RPS27A protein

NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011

G

ribosomal protein S9

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of RPS9 protein

NCBI chr 1:65,511,723...65,515,076
Ensembl chr 1:65,511,723...65,515,123

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

increases expression

Haloperidol results in increased expression of RRAD mRNA

NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417

G

ribosome binding protein 1

decreases expression

Haloperidol results in decreased expression of RRBP1 protein

NCBI chr 3:131,314,996...131,376,930
Ensembl chr 3:131,314,998...131,376,981

G

remodeling and spacing factor 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of RSF1 protein

NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051

G

reticulon 4

decreases expression

Haloperidol results in decreased expression of RTN4 mRNA

NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686

G

retinoid X receptor gamma

affects response to substance
increases expression

RXRG protein affects the susceptibility to Haloperidol
Haloperidol results in increased expression of RXRG mRNA alternative form

PMID:10336693 PMID:11564422

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

S100 calcium binding protein A9

decreases expression

Haloperidol results in decreased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

SUMO1 activating enzyme subunit 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of SAE1 protein

NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986

G

seryl-tRNA synthetase 1

decreases expression

Haloperidol results in decreased expression of SARS1 protein

NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277

G

SATB homeobox 2

decreases expression

Haloperidol results in decreased expression of SATB2 protein

NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707

G

Sbds, ribosome maturation factor

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of SBDS protein

NCBI chr12:26,420,410...26,429,650
Ensembl chr12:26,420,414...26,429,649

G

sterol-C5-desaturase

increases expression

Haloperidol results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

stearoyl-CoA desaturase

increases expression

Haloperidol results in increased expression of SCD mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

SEC61 translocon subunit alpha 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of SEC61A1 protein

NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925

G

SEC63 homolog, protein translocation regulator

increases expression

Haloperidol results in increased expression of SEC63 protein

NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055

G

serine (or cysteine) peptidase inhibitor, clade A, member 3N

increases expression

Haloperidol results in increased expression of SERPINA3 mRNA; Haloperidol results in increased expression of SERPINA3 protein

PMID:17175557 PMID:34122009

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family I member 1

decreases expression

Haloperidol results in decreased expression of SERPINI1 mRNA

NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135

G

splicing factor 3B subunit 4

decreases expression

Haloperidol results in decreased expression of SF3B4 protein

NCBI chr 2:183,732,791...183,737,545
Ensembl chr 2:183,732,754...183,737,959

G

sarcoglycan, delta

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of SGCD protein

NCBI chr10:31,346,480...32,328,364
Ensembl chr10:31,280,511...31,724,840

G

serum/glucocorticoid regulated kinase 1

increases expression

Haloperidol results in increased expression of SGK1 mRNA

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

SH3 domain-containing kinase-binding protein 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of SH3KBP1 protein

NCBI chr X:34,877,862...35,223,013
Ensembl chr X:34,877,866...35,222,747

G

SH3 and PX domains 2B

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of SH3PXD2B protein

NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170

G

solute carrier family 17 member 6

increases expression

Haloperidol results in increased expression of SLC17A6 mRNA; Haloperidol results in increased expression of SLC17A6 protein

NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542

G

solute carrier family 17 member 8

affects response to substance

SLC17A8 protein affects the susceptibility to Haloperidol

NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079

G

solute carrier family 18 member A2

affects binding

Haloperidol binds to SLC18A2 protein

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 1 member 1

decreases expression

Haloperidol results in decreased expression of SLC1A1 mRNA

NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402

G

solute carrier family 1 member 2

decreases expression

Haloperidol results in decreased expression of SLC1A2 mRNA

NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 1 member 3

decreases expression

Haloperidol results in decreased expression of SLC1A3 mRNA

NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605

G

solute carrier family 22 member 2

multiple interactions

Haloperidol inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 25 member 3

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of SLC25A3 protein

NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727

G

solute carrier family 2 member 4

increases expression

Haloperidol results in increased expression of SLC2A4 mRNA

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 39 member 7

increases expression

Haloperidol results in increased expression of SLC39A7 mRNA

NCBI chr20:4,823,166...4,826,538
Ensembl chr20:4,822,012...4,826,537

G

solute carrier family 6 member 3

multiple interactions
increases expression

SLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA]
Haloperidol results in increased expression of SLC6A3 protein

PMID:14698760 PMID:17069804

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 6 member 4

increases expression

Haloperidol results in increased expression of SLC6A4

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

synaptosome associated protein 25

affects response to substance
affects expression

SNAP25 gene SNP affects the susceptibility to Haloperidol
Haloperidol affects the expression of SNAP25 mRNA

PMID:15823421 PMID:15860345

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

G

small nuclear ribonucleoprotein D2 polypeptide

increases expression

Haloperidol results in increased expression of SNRPD2 mRNA

NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351

G

superoxide dismutase 1

increases expression
decreases expression
multiple interactions

Haloperidol results in increased expression of SOD1 mRNA
Haloperidol results in decreased expression of SOD1 protein
Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]; Haloperidol results in decreased activity of and results in decreased expression of SOD1 protein; olanzapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]; Risperidone inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]

PMID:12482469 PMID:12752374 PMID:16564057

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression
multiple interactions

Haloperidol results in decreased expression of SOD2 mRNA; Haloperidol results in decreased expression of SOD2 protein
Haloperidol results in decreased activity of and results in decreased expression of SOD2 protein

PMID:12482469 PMID:15860345 PMID:16564057

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

increases expression

Haloperidol results in increased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

striated muscle enriched protein kinase

increases expression

Haloperidol results in increased expression of SPEG protein

NCBI chr 9:76,865,714...76,923,170
Ensembl chr 9:76,865,754...76,923,144

G

sterol regulatory element binding transcription factor 2

multiple interactions

Haloperidol results in increased cleavage of and results in increased activity of SREBF2 protein

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

SRP receptor subunit alpha

decreases expression

Haloperidol results in decreased expression of SRPRA protein

NCBI chr 8:33,560,365...33,566,458
Ensembl chr 8:33,560,348...33,566,470

G

serine and arginine rich splicing factor 2

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of SRSF2 protein

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

serine and arginine rich splicing factor 5

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of SRSF5 protein

NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177

G

stress-induced phosphoprotein 1

decreases expression

Haloperidol results in decreased expression of STIP1 protein

NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476

G

striatin 4

increases expression

Haloperidol results in increased expression of STRN4 mRNA

NCBI chr 1:77,482,267...77,511,862
Ensembl chr 1:77,482,094...77,511,858

G

STT3 oligosaccharyltransferase complex catalytic subunit A

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of STT3A protein

NCBI chr 8:36,443,623...36,483,111
Ensembl chr 8:36,446,788...36,483,293

G

syntaxin 1A

increases expression

Haloperidol results in increased expression of STX1A mRNA

NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930

G

syntaxin 1B

affects expression

Haloperidol affects the expression of STX1B mRNA

NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280

G

syntaxin 4

increases expression

Haloperidol results in increased expression of STX4 mRNA

NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979

G

syntaxin 5

decreases expression

Haloperidol results in decreased expression of STX5 mRNA

NCBI chr 1:205,637,401...205,653,563
Ensembl chr 1:205,637,413...205,653,563

G

syntaxin 7

decreases expression

Haloperidol results in decreased expression of STX7 mRNA

NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279

G

syntaxin 8

affects expression

Haloperidol affects the expression of STX8 mRNA

NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993

G

SPT3 homolog, SAGA and STAGA complex component

increases expression

Haloperidol results in increased expression of SUPT3H mRNA

NCBI chr 9:15,878,296...16,206,768
Ensembl chr 9:15,868,287...16,206,706

G

synapsin II

increases expression

Haloperidol results in increased expression of SYN2 mRNA

NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192

G

synaptophysin-like 1

decreases expression

Haloperidol results in decreased expression of SYPL1 mRNA

NCBI chr 6:49,565,111...49,585,205
Ensembl chr 6:49,565,154...49,585,330

G

synaptotagmin 11

increases expression

Haloperidol results in increased expression of SYT11 mRNA

NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964

G

synaptotagmin 3

decreases expression

Haloperidol results in decreased expression of SYT3 mRNA

NCBI chr 1:94,880,835...94,895,518
Ensembl chr 1:94,881,247...94,895,246

G

synaptotagmin 4

affects expression

Haloperidol affects the expression of SYT4 mRNA

NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332

G

tachykinin, precursor 1

increases expression

Haloperidol results in increased expression of TAC1 mRNA

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

transgelin

decreases expression

Haloperidol results in decreased expression of TAGLN mRNA

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

transgelin 2

decreases expression

Haloperidol results in decreased expression of TAGLN2 protein

NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972

G

transporter 1, ATP binding cassette subfamily B member

decreases expression

Haloperidol results in decreased expression of TAP1 mRNA

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

G

TatD DNase domain containing 1

increases expression

Haloperidol results in increased expression of TATDN1 mRNA

NCBI chr 7:90,449,979...90,481,000
Ensembl chr 7:90,441,079...90,481,133

G

TRPM8 channel-associated factor 1

decreases expression

Haloperidol results in decreased expression of TCAF1 protein

NCBI chr 4:71,589,674...71,639,274
Ensembl chr 4:71,591,200...71,613,309

G

transcription elongation regulator 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of TCERG1 protein

NCBI chr18:34,505,708...34,566,470
Ensembl chr18:34,505,751...34,566,470

G

transferrin

decreases expression

Haloperidol results in decreased expression of TRF mRNA

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

trans-golgi network protein 2

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of TGOLN2 protein

NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164

G

tyrosine hydroxylase

increases expression

Haloperidol results in increased expression of TH protein

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

thyroid hormone receptor alpha

decreases expression
increases expression

Haloperidol results in decreased expression of THRA mRNA alternative form
Haloperidol results in increased expression of THRA mRNA alternative form

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

talin 2

decreases expression

Haloperidol results in decreased expression of TLN2 protein

NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219

G

transmembrane 9 superfamily member 2

decreases expression

Haloperidol results in decreased expression of TM9SF2 protein

NCBI chr15:99,201,556...99,254,054
Ensembl chr15:99,201,489...99,254,049

G

transmembrane protein 109

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of TMEM109 protein

NCBI chr 1:207,519,628...207,530,245
Ensembl chr 1:207,519,624...207,530,215

G

tropomodulin 3

decreases expression

Haloperidol results in decreased expression of TMOD3 protein

NCBI chr 8:76,248,978...76,310,855
Ensembl chr 8:76,248,979...76,310,977

G

transmembrane serine protease 2

increases expression

Haloperidol results in increased expression of TMPRSS2 mRNA

NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715

G

tumor necrosis factor

multiple interactions
increases expression

Haloperidol affects the reaction [Phencyclidine affects the expression of TNF mRNA]
Cannabidiol inhibits the reaction [Haloperidol results in increased expression of TNF mRNA]
Haloperidol results in increased expression of TNF protein

PMID:16478754 PMID:18554768 PMID:18590723 PMID:30217539

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TRAF2 and NCK interacting kinase

decreases expression

Haloperidol results in decreased expression of TNIK mRNA

NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750

G

torsin family 1, member A

affects response to substance

TOR1A gene mutant form affects the susceptibility to Haloperidol

NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691

G

tumor protein p53

increases expression

Haloperidol results in increased expression of TP53 mRNA; Haloperidol results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

triosephosphate isomerase 1

increases expression

Haloperidol results in increased expression of TPI1 mRNA

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

tripartite motif-containing 2

decreases expression

Haloperidol results in decreased expression of TRIM2 mRNA

NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927

G

tripartite motif-containing 23

decreases expression

Haloperidol results in decreased expression of TRIM23 mRNA

NCBI chr 2:35,302,405...35,335,746
Ensembl chr 2:35,302,409...35,335,743

G

tripartite motif-containing 28

decreases expression

Haloperidol results in decreased expression of TRIM28 protein

NCBI chr 1:73,652,441...73,659,388
Ensembl chr 1:73,652,709...73,659,380

G

tRNA methyltransferase 13 homolog

decreases expression

Haloperidol results in decreased expression of TRMT13 protein

NCBI chr 2:204,533,630...204,547,711
Ensembl chr 2:204,533,632...204,546,843

G

transient receptor potential cation channel, subfamily V, member 5

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of TRPV5 protein

NCBI chr 4:70,536,432...70,562,743
Ensembl chr 4:70,536,440...70,562,745

G

tau tubulin kinase 1

increases expression

Haloperidol results in increased expression of TTBK1 protein

NCBI chr 9:14,493,166...14,538,372
Ensembl chr 9:14,493,389...14,535,774

G

tubulin, beta 4B class IVb

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of TUBB4B protein

NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296

G

taxilin alpha

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of TXLNA protein

NCBI chr 5:141,969,337...141,985,054
Ensembl chr 5:141,969,346...141,984,583

G

ubiquitin A-52 residue ribosomal protein fusion product 1

increases expression

Haloperidol results in increased expression of UBA52 mRNA

NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807

G

ubiquitin C

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of UBC protein

NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925

G

ubiquitin-conjugating enzyme E2R 2

increases expression

Haloperidol results in increased expression of UBE2R2 mRNA

NCBI chr 5:56,286,604...56,345,160
Ensembl chr 5:56,286,725...56,345,513

G

ubiquilin 4

decreases expression

Haloperidol results in decreased expression of UBQLN4 protein

NCBI chr 2:174,012,726...174,028,062
Ensembl chr 2:174,012,777...174,028,059

G

upstream binding transcription factor

decreases expression

Haloperidol results in decreased expression of UBTF protein

NCBI chr10:87,258,217...87,274,291
Ensembl chr10:87,258,217...87,272,969

G

UDP-glucose pyrophosphorylase 2

increases expression

Haloperidol results in increased expression of UGP2 protein

NCBI chr14:95,456,330...95,497,483
Ensembl chr14:95,456,330...95,496,830

G

UDP glycosyltransferase 8

decreases expression

Haloperidol results in decreased expression of UGT8A mRNA

NCBI chr 2:214,264,483...214,332,769
Ensembl chr 2:214,264,483...214,332,660

G

unc-13 homolog A

decreases expression

Haloperidol results in decreased expression of UNC13A mRNA

NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872

G

ubiquinol-cytochrome c reductase, complex III subunit XI

increases expression

Haloperidol results in increased expression of UQCR11 mRNA

NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750

G

USO1 vesicle transport factor

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of USO1 protein

NCBI chr14:15,866,638...15,932,185
Ensembl chr14:15,866,638...15,932,171

G

ubiquitin specific peptidase 5

multiple interactions
increases expression

[Cuprizone co-treated with Haloperidol] results in increased expression of USP5 protein
Haloperidol results in increased expression of USP5 protein

NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711

G

ubiquitin specific peptidase 7

multiple interactions

[Cuprizone co-treated with Haloperidol] results in increased expression of USP7 protein

NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355

G

vesicle-associated membrane protein 1

decreases expression
increases expression

Haloperidol results in decreased expression of VAMP1 mRNA
Haloperidol results in increased expression of VAMP1 mRNA

NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349

G

vesicle-associated membrane protein 2

decreases expression
increases expression

Haloperidol results in decreased expression of VAMP2 mRNA
Haloperidol results in increased expression of VAMP2 mRNA

NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809

G

vasoactive intestinal peptide receptor 2

decreases expression

Haloperidol results in decreased expression of VIPR2 mRNA

NCBI chr 6:136,996,664...137,070,599
Ensembl chr 6:137,001,511...137,070,597

G

very low density lipoprotein receptor

increases expression

Haloperidol results in increased expression of VLDLR protein

NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920

G

visinin-like 1

decreases expression

Haloperidol results in decreased expression of VSNL1 mRNA

NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479

G

tryptophanyl-tRNA synthetase 1

multiple interactions

[Cuprizone co-treated with Haloperidol] results in decreased expression of WARS1 protein

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

WW domain binding protein 1-like

decreases expression

Haloperidol results in decreased expression of WBP1L mRNA

NCBI chr 1:245,472,292...245,528,627
Ensembl chr 1:245,472,296...245,528,627

G

WD repeat domain 12

decreases expression

Haloperidol results in decreased expression of WDR12 protein

NCBI chr 9:61,475,498...61,502,762
Ensembl chr 9:61,475,517...61,502,469

G

WD repeat domain, phosphoinositide interacting 1

increases expression

Haloperidol results in increased expression of WIPI1 mRNA

NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846

G

WWC family member 3

decreases expression

Haloperidol results in decreased expression of WWC3 protein

NCBI chr X:23,584,204...23,701,864
Ensembl chr X:23,584,424...23,700,513

G

xin actin-binding repeat containing 2

decreases expression

Haloperidol results in decreased expression of XIRP2 protein

NCBI chr 3:52,126,213...52,213,094
Ensembl chr 3:51,870,092...52,213,091

G

X-prolyl aminopeptidase 1

increases expression

Haloperidol results in increased expression of XPNPEP1 protein

NCBI chr 1:252,001,366...252,052,077
Ensembl chr 1:252,001,367...252,051,479

G

zinc finger RNA binding protein

decreases expression

Haloperidol results in decreased expression of ZFR protein

NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322

lisuride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

multiple interactions

Lisuride binds to and results in decreased activity of ADRA1A protein; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

5-hydroxytryptamine receptor 7

multiple interactions

[Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Lisuride binds to and results in decreased activity of HTR7 protein

PMID:18996971 PMID:19509219

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

G

interferon gamma

increases expression

Lisuride results in increased expression of IFNG

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

prolactin

multiple interactions
decreases secretion

Lisuride inhibits the reaction [Metoclopramide results in increased secretion of PRL protein]; Lisuride results in decreased expression of and results in decreased secretion of PRL protein
Lisuride analog results in decreased secretion of PRL protein; Lisuride results in decreased secretion of PRL protein

PMID:386688 PMID:6492995

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

solute carrier family 22 member 2

multiple interactions

Lisuride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

memantine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

asoxime chloride inhibits the reaction [Memantine inhibits the reaction [Soman results in decreased activity of ACHE protein]]; Memantine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Memantine inhibits the reaction [Soman results in decreased activity of ACHE protein]
Memantine results in decreased activity of ACHE protein

PMID:2241428 PMID:30588862 PMID:30682440

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

amyloid beta precursor protein

multiple interactions

Memantine inhibits the reaction [Streptozocin results in increased expression of APP protein modified form]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

activity-regulated cytoskeleton-associated protein

multiple interactions

Memantine inhibits the reaction [Lipopolysaccharides results in decreased expression of ARC protein]

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

BCL2 associated X, apoptosis regulator

affects expression

Memantine affects the expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

Memantine analog inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; Memantine inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]
Memantine results in decreased expression of BCL2 protein

PMID:29226720 PMID:32092300

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

baculoviral IAP repeat-containing 5

decreases expression

Memantine results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]; Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calpain 1

multiple interactions

Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of CAPN1 protein]

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

caspase 1

multiple interactions

Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases expression

Memantine inhibits the reaction [benzo(e)pyrene results in increased activity of CASP3 protein]; Memantine inhibits the reaction [catechol results in increased activity of CASP3 protein]; Memantine inhibits the reaction [salsolinol results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]
Memantine results in increased expression of CASP3 protein
Memantine inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CASP3 protein]
Memantine inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]

PMID:17996985 PMID:19959636 PMID:20347921 PMID:24333387 PMID:29226720 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

Memantine inhibits the reaction [benzo(e)pyrene results in increased activity of CASP7 protein]; Memantine inhibits the reaction [catechol results in increased activity of CASP7 protein]

PMID:19959636 PMID:20347921

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

increases expression

Memantine results in increased expression of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin D1

decreases expression

Memantine results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase 4

increases expression

Memantine results in increased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cAMP responsive element binding protein 1

multiple interactions

Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of CREB1 protein]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

discs large MAGUK scaffold protein 4

multiple interactions

Memantine inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein]
Memantine inhibits the reaction [Lipopolysaccharides results in decreased expression of DLG4 protein]

PMID:24333387 PMID:34474083

NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153

G

DLG associated protein 2

multiple interactions

Memantine inhibits the reaction [Streptozocin results in decreased expression of DLGAP2 mRNA]

NCBI chr16:74,786,771...75,496,402
Ensembl chr16:74,791,509...75,496,407

G

glial fibrillary acidic protein

multiple interactions

Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP mRNA]; Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP protein]
Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein]

PMID:24333387 PMID:34474083

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

Memantine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of GRIN2B protein]

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glycogen synthase kinase 3 beta

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Memantine analog inhibits the reaction [Glutamic Acid results in decreased phosphorylation of and results in increased activity of GSK3B protein]]; Memantine analog inhibits the reaction [Glutamic Acid results in decreased phosphorylation of and results in increased activity of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

interleukin 1 beta

multiple interactions

Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

integrin subunit alpha M

multiple interactions

Memantine inhibits the reaction [Streptozocin results in increased expression of ITGAM mRNA]; Memantine inhibits the reaction [Streptozocin results in increased expression of ITGAM protein]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

mitogen activated protein kinase 1

multiple interactions

Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Memantine results in decreased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

neurofilament light chain

multiple interactions

Memantine inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Memantine inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

NLR family, pyrin domain containing 3

multiple interactions

Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

proenkephalin

multiple interactions

Memantine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

protein phosphatase 2 catalytic subunit alpha

multiple interactions

[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Okadaic Acid co-treated with Fingolimod Hydrochloride co-treated with Memantine] results in increased expression of PPP2CA mRNA; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Okadaic Acid co-treated with Fingolimod Hydrochloride co-treated with Memantine] results in increased expression of PPP2CA protein

NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862

G

protein kinase C, gamma

increases expression

Memantine results in increased expression of PRKCG mRNA

NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384

G

tumor necrosis factor

multiple interactions

Memantine inhibits the reaction [Streptozocin results in increased expression of TNF protein]
Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:24333387 PMID:34474083

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

mesulergine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

5-hydroxytryptamine receptor 2B

affects binding
multiple interactions

mesulergine binds to HTR2B protein
Fluoxetine promotes the reaction [mesulergine binds to HTR2B protein]

NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108

G

5-hydroxytryptamine receptor 2C

affects binding
multiple interactions

mesulergine binds to HTR2C protein
N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [mesulergine binds to HTR2C protein]
Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]; Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]

PMID:18083778 PMID:19439326 PMID:19700373 PMID:29458138

NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287

G

5-hydroxytryptamine receptor 7

affects binding
multiple interactions

mesulergine binds to HTR7 protein
[mesulergine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; mesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]

PMID:14578406 PMID:20827463

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

G

prolactin

multiple interactions

mesulergine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

metixene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

methixene results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

orphenadrine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein like 1

affects expression

Orphenadrine affects the expression of A1BGL1 mRNA

NCBI chr 7:92,314,930...92,318,652

G

alpha-2-macroglobulin

affects expression

Orphenadrine affects the expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP-binding cassette, sub-family B member 1B

affects expression

Orphenadrine affects the expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 2

multiple interactions

[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

affects expression

Orphenadrine affects the expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily D member 2

affects expression

Orphenadrine affects the expression of ABCD2 mRNA

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

actin binding LIM protein family, member 3

affects expression

Orphenadrine affects the expression of ABLIM3 mRNA

NCBI chr18:55,256,135...55,376,629
Ensembl chr18:55,257,583...55,376,380

G

angiotensin converting enzyme 2

affects expression

Orphenadrine affects the expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

alkaline ceramidase 3

affects expression

Orphenadrine affects the expression of ACER3 mRNA

NCBI chr 1:152,504,180...152,606,596
Ensembl chr 1:152,504,186...152,606,591

G

acyl-CoA synthetase long-chain family member 5

affects expression

Orphenadrine affects the expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

acyl-CoA synthetase medium-chain family member 3

affects expression

Orphenadrine affects the expression of ACSM3 mRNA

NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184

G

adhesion G protein-coupled receptor G2

affects expression

Orphenadrine affects the expression of ADGRG2 mRNA

NCBI chr X:34,297,402...34,422,590
Ensembl chr X:34,297,402...34,422,609

G

adhesion G protein-coupled receptor V1

affects expression

Orphenadrine affects the expression of ADGRV1 mRNA

NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688

G

alcohol dehydrogenase 4 (class II), pi polypeptide

affects expression

Orphenadrine affects the expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

adenosine A1 receptor

affects expression

Orphenadrine affects the expression of ADORA1 mRNA

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2a receptor

affects expression

Orphenadrine affects the expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adrenoceptor beta 2

affects expression

Orphenadrine affects the expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

ajuba LIM protein

affects expression

Orphenadrine affects the expression of JUB mRNA

NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021

G

aldo-keto reductase family 7 member A3

affects expression

Orphenadrine affects the expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

aldehyde dehydrogenase 1 family, member A1

affects expression

Orphenadrine affects the expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

alkaline phosphatase, biomineralization associated

affects expression

Orphenadrine affects the expression of ALPL mRNA

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

ALS2 C-terminal like

affects expression

Orphenadrine affects the expression of ALS2CL mRNA

NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:110,864,975...110,884,419

G

adhesion molecule with Ig like domain 3

affects expression

Orphenadrine affects the expression of AMIGO3 mRNA

NCBI chr 8:108,741,899...108,743,425
Ensembl chr 8:108,693,060...108,744,555

G

angiomotin like 2

affects expression

Orphenadrine affects the expression of AMOTL2 mRNA

NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910

G

angiopoietin-like 4

affects expression

Orphenadrine affects the expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

angiopoietin-like 6

affects expression

Orphenadrine affects the expression of ANGPTL6 mRNA

NCBI chr 8:19,413,617...19,419,925
Ensembl chr 8:19,413,619...19,419,925

G

ankyrin repeat domain 9

affects expression

Orphenadrine affects the expression of ANKRD9 mRNA

NCBI chr 6:130,001,914...130,008,792
Ensembl chr 6:129,998,486...130,008,923

G

anoctamin 1

affects expression

Orphenadrine affects the expression of ANO1 mRNA

NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069

G

annexin A5

affects expression

Orphenadrine affects the expression of ANXA5 mRNA

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

amyloid beta precursor protein

affects expression

Orphenadrine affects the expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 9

affects expression

Orphenadrine affects the expression of AQP9 mRNA

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

Rho GTPase activating protein 10

affects expression

Orphenadrine affects the expression of ARHGAP10 mRNA

NCBI chr19:30,448,572...30,710,315
Ensembl chr19:30,448,637...30,710,313

G

Rho GTPase activating protein 22

affects expression

Orphenadrine affects the expression of ARHGAP22 mRNA

NCBI chr16:8,473,806...8,631,552
Ensembl chr16:8,476,306...8,631,548

G

Rho guanine nucleotide exchange factor 10

affects expression

Orphenadrine affects the expression of ARHGEF10 mRNA

NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173

G

Rho guanine nucleotide exchange factor 15

affects expression

Orphenadrine affects the expression of ARHGEF15 mRNA

NCBI chr10:53,650,521...53,663,269
Ensembl chr10:53,650,553...53,663,913

G

armadillo repeat containing, X-linked 1

affects expression

Orphenadrine affects the expression of ARMCX1 mRNA

NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299

G

arrestin domain containing 2

affects expression

Orphenadrine affects the expression of ARRDC2 mRNA

NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029

G

activating transcription factor 3

affects expression

Orphenadrine affects the expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATPase plasma membrane Ca2+ transporting 2

affects expression

Orphenadrine affects the expression of ATP2B2 mRNA

NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665

G

attractin like 1

affects expression

Orphenadrine affects the expression of ATRNL1 mRNA

NCBI chr 1:256,670,976...257,219,291
Ensembl chr 1:256,670,627...257,213,197

G

antizyme inhibitor 2

affects expression

Orphenadrine affects the expression of AZIN2 mRNA

NCBI chr 5:141,281,310...141,310,415
Ensembl chr 5:141,281,249...141,310,397

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9

affects expression

Orphenadrine affects the expression of B3GNT9 mRNA

NCBI chr19:33,129,740...33,134,048
Ensembl chr19:33,128,142...33,132,344

G

beta-1,4-galactosyltransferase 6

affects expression

Orphenadrine affects the expression of B4GALT6 mRNA

NCBI chr18:11,958,382...12,015,247
Ensembl chr18:11,958,390...12,015,247

G

BMP and activin membrane-bound inhibitor

affects expression

Orphenadrine affects the expression of BAMBI mRNA

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

Bcl-2 binding component 3

affects expression

Orphenadrine affects the expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL6, transcription repressor

affects expression

Orphenadrine affects the expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

beta-carotene oxygenase 2

affects expression

Orphenadrine affects the expression of BCO2 mRNA

NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467

G

basic helix-loop-helix family, member a15

affects expression

Orphenadrine affects the expression of BHLHA15 mRNA

NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713

G

BicC family RNA binding protein 1

affects expression

Orphenadrine affects the expression of BICC1 mRNA

NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776

G

bone morphogenetic protein 4

affects expression

Orphenadrine affects the expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

BTB domain containing 7

affects expression

Orphenadrine affects the expression of BTBD7 mRNA

NCBI chr 6:121,920,365...122,010,114
Ensembl chr 6:121,923,023...121,972,405

G

similar to human chromosome 11 open reading frame 24

affects expression

Orphenadrine affects the expression of C1H11ORF24 mRNA

NCBI chr 1:200,945,188...200,953,953
Ensembl chr 1:200,945,180...200,962,585

G

C1q and TNF related 2

affects expression

Orphenadrine affects the expression of C1QTNF2 mRNA

NCBI chr10:27,941,948...27,958,926
Ensembl chr10:27,941,948...27,959,185

G

similar to human chromosome 15 open reading frame 39

affects expression

Orphenadrine affects the expression of C8H15ORF39 mRNA

NCBI chr 8:57,646,324...57,655,896
Ensembl chr 8:57,645,756...57,655,941

G

calcitonin receptor like receptor

affects expression

Orphenadrine affects the expression of CALCRL mRNA

NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910

G

carbonic anhydrase 1

affects expression

Orphenadrine affects the expression of CA1 mRNA

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 2

affects expression

Orphenadrine affects the expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

affects expression

Orphenadrine affects the expression of CA3 mRNA

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

caspase recruitment domain family, member 19

affects expression

Orphenadrine affects the expression of CARD19 mRNA

NCBI chr17:15,432,632...15,445,317
Ensembl chr17:15,432,612...15,445,318

G

caspase 2

affects expression

Orphenadrine affects the expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

Cbl proto-oncogene C

affects expression

Orphenadrine affects the expression of CBLC mRNA

NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755

G

chromobox 4

affects expression

Orphenadrine affects the expression of CBX4 mRNA

NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706

G

coiled-coil domain containing 68

affects expression

Orphenadrine affects the expression of CCDC68 mRNA

NCBI chr18:63,541,828...63,584,122
Ensembl chr18:63,541,896...63,584,119

G

cellular communication network factor 1

affects expression

Orphenadrine affects the expression of CCN1 mRNA

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cyclin D1

multiple interactions

Orphenadrine promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

affects expression

Orphenadrine affects the expression of CCND2 mRNA

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

CD24 molecule

affects expression

Orphenadrine affects the expression of CD24 mRNA

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

G

Cd276 molecule

affects expression

Orphenadrine affects the expression of CD276 mRNA

NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380

G

CD36 molecule

affects expression

Orphenadrine affects the expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CDC42 effector protein 1

affects expression

Orphenadrine affects the expression of CDC42EP1 mRNA

NCBI chr 7:110,395,287...110,403,203
Ensembl chr 7:110,395,332...110,403,200

G

cadherin 3

affects expression

Orphenadrine affects the expression of CDH3 mRNA

NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084

G

cerebellar degeneration-related protein 2

affects expression

Orphenadrine affects the expression of CDR2 mRNA

NCBI chr 1:175,502,837...175,527,746
Ensembl chr 1:175,502,838...175,537,472

G

carboxylesterase 2H

affects expression

Orphenadrine affects the expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

cilia and flagella associated protein 68

affects expression

Orphenadrine affects the expression of CFAP68 mRNA

NCBI chr 8:51,107,663...51,113,192
Ensembl chr 8:51,107,721...51,113,420

G

cell growth regulator with EF hand domain 1

affects expression

Orphenadrine affects the expression of CGREF1 mRNA

NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852

G

charged multivesicular body protein 4C

affects expression

Orphenadrine affects the expression of CHMP4C mRNA

NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668

G

cell death-inducing DFFA-like effector a

affects expression

Orphenadrine affects the expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cytokine inducible SH2-containing protein

affects expression

Orphenadrine affects the expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

cardiotrophin-like cytokine factor 1

affects expression

Orphenadrine affects the expression of CLCF1 mRNA

NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605

G

claudin 23

affects expression

Orphenadrine affects the expression of CLDN23 mRNA

NCBI chr16:56,413,677...56,415,401
Ensembl chr16:56,413,381...56,415,523

G

carnosine dipeptidase 1

affects expression

Orphenadrine affects the expression of CNDP1 mRNA

NCBI chr18:77,984,886...78,030,837
Ensembl chr18:77,984,907...78,007,765

G

collagen type IV alpha 3 chain

affects expression

Orphenadrine affects the expression of COL4A3 mRNA

NCBI chr 9:83,875,849...84,004,955
Ensembl chr 9:83,875,561...84,001,895

G

carnitine palmitoyltransferase 1B

affects expression

Orphenadrine affects the expression of CPT1B mRNA

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

carnitine O-acetyltransferase

affects expression

Orphenadrine affects the expression of CRAT mRNA

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255

G

cytokine receptor-like factor 2

affects expression

Orphenadrine affects the expression of CRLF2 mRNA

NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642

G

crystallin, alpha B

affects expression

Orphenadrine affects the expression of CRYAB mRNA

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

crystallin, lambda 1

affects expression

Orphenadrine affects the expression of CRYL1 mRNA

NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997

G

CUB and Sushi multiple domains 1

affects expression

Orphenadrine affects the expression of CSMD1 mRNA

NCBI chr16:72,218,189...73,818,380
Ensembl chr16:72,218,503...73,817,614

G

cysteine and serine rich nuclear protein 1

affects expression

Orphenadrine affects the expression of CSRNP1 mRNA

NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183

G

cystatin 9-like

affects expression

Orphenadrine affects the expression of CST9L mRNA

NCBI chr 3:136,288,093...136,290,906
Ensembl chr 3:136,288,093...136,290,906

G

CTP synthase 1

affects expression

Orphenadrine affects the expression of CTPS1 mRNA

NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180

G

chymotrypsinogen B1

affects expression

Orphenadrine affects the expression of CTRB mRNA

NCBI chr19:39,652,931...39,657,689
Ensembl chr19:39,652,933...39,657,688

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
affects expression

[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA
Orphenadrine affects the expression of CYP1A1 mRNA

PMID:23665939 PMID:23665940

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

Orphenadrine inhibits the reaction [CYP1A2 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]
Orphenadrine results in decreased activity of CYP1A2 protein
Orphenadrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]

PMID:9241656 PMID:18493746

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 15

affects expression

Orphenadrine affects the expression of CYP2B15 mRNA

NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492

G

cytochrome P450, family 2, subfamily b, polypeptide 2

affects expression
multiple interactions

Orphenadrine affects the expression of CYP2B2 mRNA
[Orphenadrine co-treated with Phenobarbital] affects the expression of CYP2B2 mRNA

PMID:23665939 PMID:23665940

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
decreases activity

Orphenadrine inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]
Orphenadrine results in decreased activity of CYP2B6 protein

PMID:9241656 PMID:12464242 PMID:15306208

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily c, polypeptide 12

affects expression

Orphenadrine affects the expression of CYP2C12 mRNA

NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019

G

cytochrome P450, family 2, subfamily c, polypeptide 24

affects expression

Orphenadrine affects the expression of CYP2C24 mRNA

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity

Orphenadrine inhibits the reaction [CYP2E1 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]
Orphenadrine results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 62

affects expression

Orphenadrine affects the expression of CYP3A62 mRNA

NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833

G

cytochrome P450, family 4, subfamily a, polypeptide 1

affects expression

Orphenadrine affects the expression of CYP4A1 mRNA

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily a, polypeptide 8

affects expression

Orphenadrine affects the expression of CYP4A8 mRNA

NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476

G

cytochrome P450, family 4, subfamily b, polypeptide 1

affects expression

Orphenadrine affects the expression of CYP4B1 mRNA

NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348

G

cytochrome P450, family 4, subfamily f, polypeptide 5

affects expression

Orphenadrine affects the expression of CYP4F5 mRNA

NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978

G

cytochrome P450 family 7 subfamily A member 1

affects expression

Orphenadrine affects the expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

affects expression

Orphenadrine affects the expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

cysteine-rich transmembrane module containing 1

affects expression

Orphenadrine affects the expression of CYSTM1 mRNA

NCBI chr18:27,945,862...28,013,509
Ensembl chr18:27,951,653...28,013,510

G

cysteine and tyrosine rich 1

affects expression

Orphenadrine affects the expression of CYYR1 mRNA

NCBI chr11:24,557,620...24,664,007
Ensembl chr11:24,515,316...24,663,961

G

dishevelled-binding antagonist of beta-catenin 2

affects expression

Orphenadrine affects the expression of DACT2 mRNA

NCBI chr 1:55,181,023...55,191,026
Ensembl chr 1:55,181,024...55,191,096

G

defensin beta 36

affects expression

Orphenadrine affects the expression of DEFB36 mRNA

NCBI chr 3:141,078,001...141,086,832
Ensembl chr 3:141,086,058...141,086,728

G

disco-interacting protein 2 homolog A

affects expression

Orphenadrine affects the expression of DIP2A mRNA

NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217

G

delta like canonical Notch ligand 1

affects expression

Orphenadrine affects the expression of DLL1 mRNA

NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179

G

dynein heavy chain domain 1

affects expression

Orphenadrine affects the expression of DNHD1 mRNA

NCBI chr 1:159,990,785...160,077,990
Ensembl chr 1:159,990,438...160,074,858

G

dipeptidyl peptidase like 6

affects expression

Orphenadrine affects the expression of DPP6 mRNA

NCBI chr 4:7,589,386...8,508,666
Ensembl chr 4:7,591,009...8,508,532

G

developmental pluripotency associated 3 like 2

affects expression

Orphenadrine affects the expression of DPPA3L2 mRNA

NCBI chr17:2,886,537...2,887,217

G

DNA-damage regulated autophagy modulator 1

affects expression

Orphenadrine affects the expression of DRAM1 mRNA

NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765

G

dual specificity phosphatase 1

affects expression

Orphenadrine affects the expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 10

affects expression

Orphenadrine affects the expression of DUSP10 mRNA

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

G

dual specificity phosphatase 13B

affects expression

Orphenadrine affects the expression of DUSP13B mRNA

NCBI chr15:2,567,432...2,575,105
Ensembl chr15:2,533,547...2,575,539

G

dual specificity phosphatase 16

affects expression

Orphenadrine affects the expression of DUSP16 mRNA

NCBI chr 4:167,546,780...167,630,173
Ensembl chr 4:167,548,155...167,629,980

G

dual specificity phosphatase 8

affects expression

Orphenadrine affects the expression of DUSP8 mRNA

NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921

G

estrogen-induced osteoclastogenesis regulator 1

affects expression

Orphenadrine affects the expression of EEIG1 mRNA

NCBI chr 3:15,822,441...15,854,651
Ensembl chr 3:15,823,144...15,854,643

G

EEIG family member 2

affects expression

Orphenadrine affects the expression of EEIG2 mRNA

NCBI chr 2:196,608,499...196,663,371
Ensembl chr 2:196,608,499...196,663,371

G

EGF containing fibulin extracellular matrix protein 1

affects expression

Orphenadrine affects the expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

egl-9 family hypoxia-inducible factor 3

affects expression

Orphenadrine affects the expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

early growth response 1

affects expression

Orphenadrine affects the expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

elastin microfibril interfacer 1

affects expression

Orphenadrine affects the expression of EMILIN1 mRNA

NCBI chr 6:25,455,974...25,463,713
Ensembl chr 6:25,445,298...25,463,698

G

Eph receptor A2

affects expression

Orphenadrine affects the expression of EPHA2 mRNA

NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117

G

EPH receptor B4

affects expression

Orphenadrine affects the expression of EPHB4 mRNA

NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314

G

ERI1 exoribonuclease family member 2

affects expression

Orphenadrine affects the expression of ERI2 mRNA

NCBI chr 1:174,140,831...174,168,757
Ensembl chr 1:174,141,993...174,168,665

G

coagulation factor VIII

affects expression

Orphenadrine affects the expression of F8 mRNA

NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857

G

family with sequence similarity 89, member A

affects expression

Orphenadrine affects the expression of FAM89A mRNA

NCBI chr19:52,710,002...52,722,630
Ensembl chr19:52,710,019...52,722,631

G

F-box protein 27

affects expression

Orphenadrine affects the expression of FBXO27 mRNA

NCBI chr 1:83,965,426...83,987,781
Ensembl chr 1:83,965,986...83,987,778

G

fer-1-like family member 5

affects expression

Orphenadrine affects the expression of FER1L5 mRNA

NCBI chr 9:38,605,835...38,661,869
Ensembl chr 9:38,607,843...38,660,425

G

FYVE, RhoGEF and PH domain containing 5

affects expression

Orphenadrine affects the expression of FGD5 mRNA

NCBI chr 4:124,497,061...124,594,564
Ensembl chr 4:124,497,068...124,594,563

G

Fms related receptor tyrosine kinase 1

affects expression

Orphenadrine affects the expression of FLT1 mRNA

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

Fms related receptor tyrosine kinase 4

affects expression

Orphenadrine affects the expression of FLT4 mRNA

NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770

G

flavin containing dimethylaniline monoxygenase 1

affects expression

Orphenadrine affects the expression of FMO1 mRNA

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

fibronectin type III domain containing 5

affects expression

Orphenadrine affects the expression of FNDC5 mRNA

NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731

G

follistatin

affects expression

Orphenadrine affects the expression of FST mRNA

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

growth arrest and DNA-damage-inducible, gamma

affects expression

Orphenadrine affects the expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

growth differentiation factor 11

affects expression

Orphenadrine affects the expression of GDF11 mRNA

NCBI chr 7:1,311,732...1,325,211
Ensembl chr 7:1,311,732...1,320,725

G

gamma-glutamyltransferase 1

affects expression

Orphenadrine affects the expression of GGT1 mRNA

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

GIMAP family P-loop NTPase domain containing 1

affects expression

Orphenadrine affects the expression of GIMD1 mRNA

NCBI chr 2:221,103,878...221,138,559
Ensembl chr 2:221,103,878...221,138,553

G

GIPC PDZ domain containing family, member 2

affects expression

Orphenadrine affects the expression of GIPC2 mRNA

NCBI chr 2:241,030,764...241,110,236
Ensembl chr 2:241,030,770...241,110,236

G

Gem-interacting protein

affects expression

Orphenadrine affects the expression of GMIP mRNA

NCBI chr16:19,600,723...19,614,459
Ensembl chr16:19,600,723...19,614,027

G

G protein subunit alpha 14

affects expression

Orphenadrine affects the expression of GNA14 mRNA

NCBI chr 1:213,714,993...213,900,083
Ensembl chr 1:213,716,020...213,897,423

G

G protein subunit alpha i1

affects expression

Orphenadrine affects the expression of GNAI1 mRNA

NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417

G

glycerol-3-phosphate acyltransferase 3

affects expression

Orphenadrine affects the expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

G protein-coupled receptor 17

affects expression

Orphenadrine affects the expression of GPR17 mRNA

NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966

G

glutathione peroxidase 2

affects expression
multiple interactions

Orphenadrine affects the expression of GPX2 mRNA
[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA; [Phenobarbital co-treated with Orphenadrine] affects the expression of GPX2 mRNA

PMID:23665939 PMID:23665940

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutamate ionotropic receptor AMPA type subunit 3

affects expression

Orphenadrine affects the expression of GRIA3 mRNA

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

glutamate ionotropic receptor kainate type subunit 5

affects expression

Orphenadrine affects the expression of GRIK5 mRNA

NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125

G

Gse1 coiled-coil protein

affects expression

Orphenadrine affects the expression of GSE1 mRNA

NCBI chr19:48,274,164...48,629,456
Ensembl chr19:48,274,127...48,629,458

G

glutathione S-transferase mu 4

affects expression

Orphenadrine affects the expression of GSTM4 mRNA

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase, mu 5

multiple interactions
affects expression

[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA; [Phenobarbital co-treated with Orphenadrine] affects the expression of GSTM3 mRNA
Orphenadrine affects the expression of GSTM3 mRNA

PMID:23665939 PMID:23665940

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

glutathione S-transferase pi 1

affects expression

Orphenadrine affects the expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

histidine ammonia lyase

affects expression

Orphenadrine affects the expression of HAL mRNA

NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701

G

heme binding protein 2

affects expression

Orphenadrine affects the expression of HEBP2 mRNA

NCBI chr 1:13,194,982...13,201,777
Ensembl chr 1:13,194,982...13,201,777

G

hes family bHLH transcription factor 1

affects expression

Orphenadrine affects the expression of HES1 mRNA

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hepatocyte growth factor

affects expression

Orphenadrine affects the expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

HID1 domain containing

affects expression

Orphenadrine affects the expression of HID1 mRNA

NCBI chr10:100,589,555...100,610,050
Ensembl chr10:100,589,555...100,610,041

G

heat shock protein family A (Hsp70) member 1A

affects expression

Orphenadrine affects the expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

affects expression

Orphenadrine affects the expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

hyccin PI4KA lipid kinase complex subunit 1

affects expression

Orphenadrine affects the expression of HYCC1 mRNA

NCBI chr 4:11,132,224...11,239,120
Ensembl chr 4:11,132,385...11,239,113

G

inhibitor of DNA binding 1

affects expression

Orphenadrine affects the expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 3

affects expression

Orphenadrine affects the expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

indoleamine 2,3-dioxygenase 2

affects expression

Orphenadrine affects the expression of IDO2 mRNA

NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324

G

immediate early response 5

affects expression

Orphenadrine affects the expression of IER5 mRNA

NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227

G

insulin-like growth factor binding protein 1

affects expression

Orphenadrine affects the expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

Indian hedgehog signaling molecule

affects expression

Orphenadrine affects the expression of IHH mRNA

NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

affects expression

Orphenadrine affects the expression of IKBKG mRNA

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

interleukin 17 receptor B

affects expression

Orphenadrine affects the expression of IL17RB mRNA

NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125

G

interleukin 33

affects expression

Orphenadrine affects the expression of IL33 mRNA

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

inverted formin 2

affects expression

Orphenadrine affects the expression of INF2 mRNA

NCBI chr 6:131,649,162...131,675,944
Ensembl chr 6:131,649,211...131,675,941

G

inositol hexakisphosphate kinase 2

affects expression

Orphenadrine affects the expression of IP6K2 mRNA

NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166

G

interferon regulatory factor 7

affects expression

Orphenadrine affects the expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

iroquois homeobox 1

affects expression

Orphenadrine affects the expression of IRX1 mRNA

NCBI chr 1:31,294,615...31,300,444
Ensembl chr 1:31,294,615...31,300,444

G

ISG15 ubiquitin-like modifier

affects expression

Orphenadrine affects the expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

integrin subunit beta 3

affects expression

Orphenadrine affects the expression of ITGB3 mRNA

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects expression

Orphenadrine affects the expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

affects expression

Orphenadrine affects the expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

type I keratin KA11

affects expression

Orphenadrine affects the expression of KA11 mRNA

NCBI chr10:85,161,424...85,164,737
Ensembl chr10:85,066,802...85,171,799

G

KN motif and ankyrin repeat domains 2

affects expression

Orphenadrine affects the expression of KANK2 mRNA

NCBI chr 8:20,311,676...20,341,107
Ensembl chr 8:20,311,676...20,340,900

G

potassium inwardly-rectifying channel, subfamily J, member 15

affects expression

Orphenadrine affects the expression of KCNJ15 mRNA

NCBI chr11:34,577,397...34,621,725
Ensembl chr11:34,577,363...34,621,952

G

potassium two pore domain channel subfamily K member 5

affects expression

Orphenadrine affects the expression of KCNK5 mRNA

NCBI chr15:4,122,442...4,164,718
Ensembl chr15:4,122,442...4,164,718

G

KLF transcription factor 10

affects expression

Orphenadrine affects the expression of KLF10 mRNA

NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994

G

kelch-like family member 21

affects expression

Orphenadrine affects the expression of KLHL21 mRNA

NCBI chr 5:162,514,888...162,523,545
Ensembl chr 5:162,514,765...162,523,545

G

kynurenine 3-monooxygenase

affects expression

Orphenadrine affects the expression of KMO mRNA

NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881

G

keratin 10

affects expression

Orphenadrine affects the expression of KRT10 mRNA

NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701

G

keratin 8

affects expression

Orphenadrine affects the expression of KRT8 mRNA

NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728

G

lymphocyte activating 3

affects expression

Orphenadrine affects the expression of LAG3 mRNA

NCBI chr 4:157,712,665...157,722,229
Ensembl chr 4:157,712,667...157,720,404

G

leucine, glutamate and lysine rich 1

affects expression

Orphenadrine affects the expression of LEKR1 mRNA

NCBI chr 2:149,889,615...150,061,167
Ensembl chr 2:149,891,106...150,060,469

G

galectin 2

affects expression

Orphenadrine affects the expression of LGALS2 mRNA

NCBI chr 7:110,403,171...110,410,046
Ensembl chr 7:110,403,173...110,404,802

G

LIM homeobox 8

affects expression

Orphenadrine affects the expression of LHX8 mRNA

NCBI chr 2:243,244,958...243,269,624
Ensembl chr 2:243,244,961...243,269,416

G

leukocyte immunoglobulin like receptor B4

affects expression

Orphenadrine affects the expression of LILRB4 mRNA

NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660

G

lin-7 homolog A, crumbs cell polarity complex component

affects expression

Orphenadrine affects the expression of LIN7A mRNA

NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550

G

leiomodin 2

affects expression

Orphenadrine affects the expression of LMOD2 mRNA

NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120

G

lysyl oxidase-like 4

affects expression

Orphenadrine affects the expression of LOXL4 mRNA

NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:241,397,983...241,416,322

G

lysophosphatidylcholine acyltransferase 4

affects expression

Orphenadrine affects the expression of LPCAT4 mRNA

NCBI chr 3:99,044,729...99,052,963
Ensembl chr 3:99,044,729...99,052,875

G

lipin 2

affects expression

Orphenadrine affects the expression of LPIN2 mRNA

NCBI chr 9:111,083,378...111,158,193
Ensembl chr 9:111,083,745...111,158,193

G

lipoprotein lipase

affects expression

Orphenadrine affects the expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

leucine rich repeat neuronal 4

affects expression

Orphenadrine affects the expression of LRRN4 mRNA

NCBI chr 3:120,138,093...120,150,877
Ensembl chr 3:120,139,410...120,150,831

G

leukotriene C4 synthase

affects expression

Orphenadrine affects the expression of LTC4S mRNA

NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651

G

MAF bZIP transcription factor B

affects expression

Orphenadrine affects the expression of MAFB mRNA

NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031

G

MAGE family member E1

affects expression

Orphenadrine affects the expression of MAGEE1 mRNA

NCBI chr X:70,189,242...70,192,789
Ensembl chr X:70,189,187...70,192,810

G

microtubule-associated protein 1S

affects expression

Orphenadrine affects the expression of MAP1S mRNA

NCBI chr16:18,516,759...18,527,777
Ensembl chr16:18,517,574...18,527,988

G

mitogen activated protein kinase kinase kinase kinase 2

affects expression

Orphenadrine affects the expression of MAP4K2 mRNA

NCBI chr 1:203,645,098...203,660,782
Ensembl chr 1:203,645,153...203,660,331

G

mitogen-activated protein kinase kinase kinase kinase 4

affects expression

Orphenadrine affects the expression of MAP4K4 mRNA

NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698

G

mitogen-activated protein kinase 12

affects expression

Orphenadrine affects the expression of MAPK12 mRNA

NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664

G

matrilin 4

affects expression

Orphenadrine affects the expression of MATN4 mRNA

NCBI chr 3:153,120,605...153,135,628
Ensembl chr 3:153,120,632...153,135,865

G

melanoma cell adhesion molecule

affects expression

Orphenadrine affects the expression of MCAM mRNA

NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571

G

methionyl aminopeptidase type 1D (mitochondrial)

affects expression

Orphenadrine affects the expression of METAP1D mRNA

NCBI chr 3:56,279,471...56,354,518
Ensembl chr 3:56,279,493...56,351,981

G

mex-3 RNA binding family member B

affects expression

Orphenadrine affects the expression of MEX3B mRNA

NCBI chr 1:136,855,130...136,859,365
Ensembl chr 1:136,855,130...136,859,354

G

mex-3 RNA binding family member D

affects expression

Orphenadrine affects the expression of MEX3D mRNA

NCBI chr 7:9,325,575...9,332,705
Ensembl chr 7:9,325,488...9,332,096

G

milk fat globule EGF and factor V/VIII domain containing

affects expression

Orphenadrine affects the expression of MFGE8 mRNA

NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073

G

midline 1

affects expression

Orphenadrine affects the expression of MID1 mRNA

NCBI chr X:24,116,674...24,491,205
Ensembl chr X:24,120,293...24,248,353

G

MID1 interacting protein 1

affects expression

Orphenadrine affects the expression of MID1IP1 mRNA

NCBI chr X:12,060,993...12,063,318
Ensembl chr X:12,060,883...12,065,774

G

midnolin

affects expression

Orphenadrine affects the expression of MIDN mRNA

NCBI chr 7:9,548,100...9,559,605
Ensembl chr 7:9,549,650...9,559,752

G

MAPK interacting serine/threonine kinase 2

affects expression

Orphenadrine affects the expression of MKNK2 mRNA

NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827

G

MLX interacting protein

affects expression

Orphenadrine affects the expression of MLXIP mRNA

NCBI chr12:33,128,524...33,192,300
Ensembl chr12:33,128,520...33,192,374

G

monocyte to macrophage differentiation-associated

affects expression

Orphenadrine affects the expression of MMD mRNA

NCBI chr10:75,073,278...75,101,528
Ensembl chr10:75,073,365...75,101,528

G

matrix metallopeptidase 12

affects expression

Orphenadrine affects the expression of MMP12 mRNA

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 15

affects expression

Orphenadrine affects the expression of MMP15 mRNA

NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943

G

muscle RAS oncogene homolog

affects expression

Orphenadrine affects the expression of MRAS mRNA

NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408

G

maestro heat-like repeat family member 2A

affects expression

Orphenadrine affects the expression of MROH2A mRNA

NCBI chr 9:88,814,515...88,862,346
Ensembl chr 9:88,814,197...88,852,607

G

macrophage stimulating 1 receptor

affects expression

Orphenadrine affects the expression of MST1R mRNA

NCBI chr 8:108,596,100...108,611,441
Ensembl chr 8:108,597,299...108,612,455

G

myotubularin related protein 7

affects expression

Orphenadrine affects the expression of MTMR7 mRNA

NCBI chr16:51,641,267...51,732,212
Ensembl chr16:51,641,190...51,732,182

G

MTSS I-BAR domain containing 2

affects expression

Orphenadrine affects the expression of MTSS2 mRNA

NCBI chr19:38,692,793...38,714,575
Ensembl chr19:38,693,194...38,713,507

G

MX dynamin like GTPase 2

affects expression

Orphenadrine affects the expression of MX2 mRNA

NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342

G

myosin binding protein H

affects expression

Orphenadrine affects the expression of MYBPH mRNA

NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893

G

Myb-related transcription factor, partner of profilin

affects expression

Orphenadrine affects the expression of MYPOP mRNA

NCBI chr 1:78,639,699...78,650,555
Ensembl chr 1:78,639,769...78,650,552

G

myelin regulatory factor

affects expression

Orphenadrine affects the expression of MYRF mRNA

NCBI chr 1:206,854,175...206,886,276
Ensembl chr 1:206,854,175...206,886,157

G

N-acetyltransferase 8 (GCN5-related) family member 2

affects expression

Orphenadrine affects the expression of NAT8F2 mRNA

NCBI chr 4:118,319,984...118,323,159
Ensembl chr 4:118,319,988...118,324,395

G

non-SMC condensin I complex, subunit H

affects expression

Orphenadrine affects the expression of NCAPH mRNA

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

nuclear receptor coactivator 7

affects expression

Orphenadrine affects the expression of NCOA7 mRNA

NCBI chr 1:26,856,228...27,016,950
Ensembl chr 1:26,856,530...27,015,871

G

neurofilament heavy chain

affects expression

Orphenadrine affects the expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

neuralized E3 ubiquitin protein ligase 3

affects expression

Orphenadrine affects the expression of NEURL3 mRNA

NCBI chr 9:38,494,486...38,503,352
Ensembl chr 9:38,494,489...38,502,649

G

NFKB inhibitor zeta

affects expression

Orphenadrine affects the expression of NFKBIZ mRNA

NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723

G

NHS like 3

affects expression

Orphenadrine affects the expression of NHSL3 mRNA

NCBI chr 5:141,564,399...141,593,154
Ensembl chr 5:141,564,399...141,593,176

G

ninjurin 2

affects expression

Orphenadrine affects the expression of NINJ2 mRNA

NCBI chr 4:153,306,439...153,408,618
Ensembl chr 4:153,306,553...153,408,617

G

NIPA-like domain containing 2

affects expression

Orphenadrine affects the expression of NIPAL2 mRNA

NCBI chr 7:65,774,477...65,884,807
Ensembl chr 7:65,774,477...65,884,807

G

NLR family, CARD domain containing 4

affects expression

Orphenadrine affects the expression of NLRC4 mRNA

NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248

G

nocturnin

affects expression

Orphenadrine affects the expression of NOCT mRNA

NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400

G

nitric oxide synthase 1 adaptor protein

affects expression

Orphenadrine affects the expression of NOS1AP mRNA

NCBI chr13:82,547,799...82,820,999
Ensembl chr13:82,530,577...82,820,949

G

nitric oxide synthase 3

affects expression

Orphenadrine affects the expression of NOS3 mRNA

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

neuropeptide Y

affects expression

Orphenadrine affects the expression of NPY mRNA

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

nuclear receptor subfamily 1, group D, member 1

affects expression

Orphenadrine affects the expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

neuronal regeneration related protein

affects expression

Orphenadrine affects the expression of NREP mRNA

NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591

G

neuregulin 1

affects expression

Orphenadrine affects the expression of NRG1 mRNA

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

neurexin 1

affects expression

Orphenadrine affects the expression of NRXN1 mRNA

NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710

G

nuclear protein 1, transcriptional regulator

affects expression

Orphenadrine affects the expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

ornithine aminotransferase

affects expression

Orphenadrine affects the expression of OAT mRNA

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

osteoglycin

affects expression

Orphenadrine affects the expression of OGN mRNA

NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739

G

olfactory receptor 1198

affects expression

Orphenadrine affects the expression of OLR1198 mRNA

NCBI chr 8:37,575,356...37,576,285
Ensembl chr 8:37,574,531...37,576,995

G

olfactory receptor 1428

affects expression

Orphenadrine affects the expression of OLR1428 mRNA

NCBI chr10:42,947,353...42,948,300
Ensembl chr10:42,944,142...42,948,881

G

olfactory receptor 1451

affects expression

Orphenadrine affects the expression of OLR1451 mRNA

NCBI chr10:43,429,140...43,430,069
Ensembl chr10:43,424,036...43,432,210

G

osteomodulin

affects expression

Orphenadrine affects the expression of OMD mRNA

NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441

G

olfactory receptor family 2 subfamily N member 1L

affects expression

Orphenadrine affects the expression of OR2N1L mRNA

NCBI chr20:340,574...341,512

G

olfactory receptor family 2 subfamily Y member 1I

affects expression

Orphenadrine affects the expression of OR2Y1I mRNA

NCBI chr10:33,737,199...33,738,128
Ensembl chr10:33,732,012...33,738,729

G

oxidative stress induced growth inhibitor 1

affects expression

Orphenadrine affects the expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

prolyl 3-hydroxylase 2

affects expression

Orphenadrine affects the expression of P3H2 mRNA

NCBI chr11:74,634,267...74,775,422
Ensembl chr11:74,634,267...74,775,421

G

prolyl 3-hydroxylase family member 4

affects expression

Orphenadrine affects the expression of P3H4 mRNA

NCBI chr10:85,338,158...85,345,108
Ensembl chr10:85,338,161...85,345,093

G

pannexin 2

affects expression

Orphenadrine affects the expression of PANX2 mRNA

NCBI chr 7:120,139,259...120,153,056
Ensembl chr 7:120,139,294...120,152,361

G

protocadherin 12

affects expression

Orphenadrine affects the expression of PCDH12 mRNA

NCBI chr18:30,103,728...30,119,307
Ensembl chr18:30,103,728...30,119,307

G

Purkinje cell protein 4-like 1

affects expression

Orphenadrine affects the expression of PCP4L1 mRNA

NCBI chr13:83,588,992...83,612,631
Ensembl chr13:83,588,992...83,609,966

G

proprotein convertase subtilisin/kexin type 9

affects expression

Orphenadrine affects the expression of PCSK9 mRNA

NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688

G

phosphodiesterase 5A

affects expression

Orphenadrine affects the expression of PDE5A mRNA

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

pyruvate dehydrogenase kinase 4

affects expression

Orphenadrine affects the expression of PDK4 mRNA

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

podoplanin

affects expression

Orphenadrine affects the expression of PDPN mRNA

NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656

G

period circadian regulator 2

affects expression

Orphenadrine affects the expression of PER2 mRNA

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

G

phosphofructokinase, muscle

affects expression

Orphenadrine affects the expression of PFKM mRNA

NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192

G

pleckstrin homology-like domain, family A, member 2

affects expression

Orphenadrine affects the expression of PHLDA2 mRNA

NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836

G

pleckstrin homology-like domain, family A, member 3

affects expression

Orphenadrine affects the expression of PHLDA3 mRNA

NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335

G

pleckstrin homology-like domain, family B, member 3

affects expression

Orphenadrine affects the expression of PHLDB3 mRNA

NCBI chr 1:80,201,083...80,219,541
Ensembl chr 1:80,201,578...80,219,534

G

phosphoethanolamine/phosphocholine phosphatase 1

affects expression

Orphenadrine affects the expression of PHOSPHO1 mRNA

NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342

G

phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

affects expression

Orphenadrine affects the expression of PIP5K1C mRNA

NCBI chr 7:8,397,406...8,426,030
Ensembl chr 7:8,397,406...8,425,988

G

pleckstrin homology and FYVE domain containing 2

affects expression

Orphenadrine affects the expression of PLEKHF2 mRNA

NCBI chr 5:24,091,077...24,106,758
Ensembl chr 5:24,090,688...24,106,601

G

pleckstrin homology, MyTH4 and FERM domain containing H1

affects expression

Orphenadrine affects the expression of PLEKHH1 mRNA

NCBI chr 6:97,839,288...97,888,712
Ensembl chr 6:97,839,288...97,888,709

G

perilipin 3

affects expression

Orphenadrine affects the expression of PLIN3 mRNA

NCBI chr 9:1,111,178...1,123,057
Ensembl chr 9:1,102,366...1,123,147

G

prostate transmembrane protein, androgen induced 1

affects expression

Orphenadrine affects the expression of PMEPA1 mRNA

NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454

G

peripheral myelin protein 22

affects expression

Orphenadrine affects the expression of PMP22 mRNA

NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714

G

DNA polymerase gamma 2, accessory subunit

affects expression

Orphenadrine affects the expression of POLG2 mRNA

NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008

G

protein phosphatase, Mg2+/Mn2+ dependent, 1J

affects expression

Orphenadrine affects the expression of PPM1J mRNA

NCBI chr 2:192,278,597...192,283,883
Ensembl chr 2:192,278,517...192,283,882

G

protein phosphatase, Mg2+/Mn2+ dependent, 1K

affects expression

Orphenadrine affects the expression of PPM1K mRNA

NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152

G

protein phosphatase 1, regulatory (inhibitor) subunit 1A

affects expression

Orphenadrine affects the expression of PPP1R1A mRNA

NCBI chr 7:134,654,578...134,662,236
Ensembl chr 7:134,654,579...134,662,230

G

PRELI domain containing 2

affects expression

Orphenadrine affects the expression of PRELID2 mRNA

NCBI chr18:33,869,934...33,961,320
Ensembl chr18:33,873,599...33,961,225

G

protein kinase C, eta

affects expression

Orphenadrine affects the expression of PRKCH mRNA

NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654

G

prolactin receptor

affects expression

Orphenadrine affects the expression of PRLR mRNA

NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718

G

proline rich protein 2

affects expression

Orphenadrine affects the expression of PRP2 mRNA

NCBI chr 4:165,600,085...165,603,662

G

proline rich and Gla domain 4

affects expression

Orphenadrine affects the expression of PRRG4 mRNA

NCBI chr 3:91,214,646...91,243,347
Ensembl chr 3:91,214,653...91,243,273

G

serine protease 53

affects expression

Orphenadrine affects the expression of PRSS53 mRNA

NCBI chr 1:182,494,944...182,501,607
Ensembl chr 1:182,494,955...182,500,115

G

protein tyrosine phosphatase, receptor type, N

affects expression

Orphenadrine affects the expression of PTPRN mRNA

NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190

G

PVR cell adhesion molecule

affects expression

Orphenadrine affects the expression of PVR mRNA

NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715

G

PWWP domain containing 2B

affects expression

Orphenadrine affects the expression of PWWP2B mRNA

NCBI chr 1:194,040,395...194,059,979
Ensembl chr 1:194,041,341...194,059,958

G

RAB11 family interacting protein 5

affects expression

Orphenadrine affects the expression of RAB11FIP5 mRNA

NCBI chr 4:117,871,301...117,908,819
Ensembl chr 4:117,871,308...117,908,741

G

RAB23, member RAS oncogene family

affects expression

Orphenadrine affects the expression of RAB23 mRNA

NCBI chr 9:35,943,522...35,967,367
Ensembl chr 9:35,944,085...35,966,927

G

RAB3D, member RAS oncogene family

affects expression

Orphenadrine affects the expression of RAB3D mRNA

NCBI chr 8:20,438,622...20,449,269
Ensembl chr 8:20,439,294...20,449,185

G

retinoic acid receptor, gamma

affects expression

Orphenadrine affects the expression of RARG mRNA

NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177

G

Ras association domain family member 1

affects expression

Orphenadrine affects the expression of RASSF1 mRNA

NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164

G

RELT-like 1

affects expression

Orphenadrine affects the expression of RELL1 mRNA

NCBI chr14:44,318,640...44,378,541
Ensembl chr14:44,303,009...44,378,500

G

renin binding protein

affects expression

Orphenadrine affects the expression of RENBP mRNA

NCBI chr X:151,661,463...151,670,538
Ensembl chr X:151,661,458...151,670,516

G

replication initiator 1

affects expression

Orphenadrine affects the expression of REPIN1 mRNA

NCBI chr 4:77,548,724...77,554,242
Ensembl chr 4:77,548,849...77,554,257

G

regulated endocrine-specific protein 18

affects expression

Orphenadrine affects the expression of RESP18 mRNA

NCBI chr 9:76,765,179...76,771,824
Ensembl chr 9:76,764,590...76,778,722

G

regulator of G-protein signaling 16

affects expression

Orphenadrine affects the expression of RGS16 mRNA

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

G

rhomboid 5 homolog 2

affects expression

Orphenadrine affects the expression of RHBDF2 mRNA

NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283

G

ras homolog family member C

affects expression

Orphenadrine affects the expression of RHOC mRNA

NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306

G

ras homolog family member F, filopodia associated

affects expression

Orphenadrine affects the expression of RHOF mRNA

NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703

G

regulator of microtubule dynamics 2

affects expression

Orphenadrine affects the expression of RMDN2 mRNA

NCBI chr 6:15,372,569...15,443,000
Ensembl chr 6:15,375,496...15,441,480

G

Rho family GTPase 1

affects expression

Orphenadrine affects the expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

somatomedin B and thrombospondin, type 1 domain containing

affects expression

Orphenadrine affects the expression of SBSPON mRNA

NCBI chr 5:3,402,763...3,433,338
Ensembl chr 5:3,402,648...3,435,420

G

stearoyl-CoA desaturase

affects expression

Orphenadrine affects the expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

sodium channel epithelial 1 subunit alpha

affects expression

Orphenadrine affects the expression of SCNN1A mRNA

NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181

G

syndecan 3

affects expression

Orphenadrine affects the expression of SDC3 mRNA

NCBI chr 5:142,965,659...142,998,390
Ensembl chr 5:142,965,591...142,996,480

G

SEBOX homeobox

affects expression

Orphenadrine affects the expression of SEBOX mRNA

NCBI chr10:63,399,215...63,400,086
Ensembl chr10:63,399,165...63,400,606

G

serine incorporator 2

affects expression

Orphenadrine affects the expression of SERINC2 mRNA

NCBI chr 5:142,592,308...142,614,628
Ensembl chr 5:142,592,309...142,618,364

G

serpin family A member 7

affects expression

Orphenadrine affects the expression of SERPINA7 mRNA

NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040

G

SERTA domain containing 1

affects expression

Orphenadrine affects the expression of SERTAD1 mRNA

NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091

G

SET domain containing 7, histone lysine methyltransferase

affects expression

Orphenadrine affects the expression of SETD7 mRNA

NCBI chr 2:135,562,683...135,605,468
Ensembl chr 2:135,562,683...135,605,468

G

serum/glucocorticoid regulated kinase 1

affects expression

Orphenadrine affects the expression of SGK1 mRNA

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

SH3 and PX domains 2B

affects expression

Orphenadrine affects the expression of SH3PXD2B mRNA

NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170

G

SH3 and multiple ankyrin repeat domains 3

affects expression

Orphenadrine affects the expression of SHANK3 mRNA

NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374

G

shisa family member 4

affects expression

Orphenadrine affects the expression of SHISA4 mRNA

NCBI chr13:46,799,735...46,803,816
Ensembl chr13:46,799,772...46,803,998

G

shroom family member 3

affects expression

Orphenadrine affects the expression of SHROOM3 mRNA

NCBI chr14:15,099,415...15,396,832
Ensembl chr14:15,099,423...15,396,915

G

SID1 transmembrane family, member 1

affects expression

Orphenadrine affects the expression of SIDT1 mRNA

NCBI chr11:56,362,788...56,459,939
Ensembl chr11:56,363,512...56,459,050

G

SIN3-HDAC complex associated factor

affects expression

Orphenadrine affects the expression of SINHCAF mRNA

NCBI chr 4:181,888,301...181,913,294
Ensembl chr 4:181,888,312...181,910,276

G

signal-induced proliferation-associated 1

affects expression

Orphenadrine affects the expression of SIPA1 mRNA

NCBI chr 1:202,938,532...202,950,672
Ensembl chr 1:202,938,580...202,950,591

G

SKI-like proto-oncogene

affects expression

Orphenadrine affects the expression of SKIL mRNA

NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080

G

solute carrier family 12 member 4

affects expression

Orphenadrine affects the expression of SLC12A4 mRNA

NCBI chr19:33,838,418...33,860,369
Ensembl chr19:33,838,419...33,860,331

G

solute carrier family 16 member 10

affects expression

Orphenadrine affects the expression of SLC16A10 mRNA

NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839

G

solute carrier family 16, member 11

affects expression

Orphenadrine affects the expression of SLC16A11 mRNA

NCBI chr10:54,929,129...54,933,021
Ensembl chr10:54,927,725...54,942,915

G

solute carrier family 16, member 14

affects expression

Orphenadrine affects the expression of SLC16A14 mRNA

NCBI chr 9:86,110,066...86,137,546
Ensembl chr 9:86,112,894...86,137,318

G

solute carrier family 16 member 5

affects expression

Orphenadrine affects the expression of SLC16A5 mRNA

NCBI chr10:100,707,434...100,721,338
Ensembl chr10:100,707,434...100,721,338

G

solute carrier family 16, member 6

affects expression

Orphenadrine affects the expression of SLC16A6 mRNA

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 1 member 4

affects expression

Orphenadrine affects the expression of SLC1A4 mRNA

NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418

G

solute carrier family 22 member 2

multiple interactions

Orphenadrine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Orphenadrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 30 member 2

affects expression

Orphenadrine affects the expression of SLC30A2 mRNA

NCBI chr 5:146,559,733...146,571,957
Ensembl chr 5:146,559,733...146,571,956

G

solute carrier family 35, member F2

affects expression

Orphenadrine affects the expression of SLC35F2 mRNA

NCBI chr 8:54,159,970...54,203,614
Ensembl chr 8:54,159,970...54,203,612

G

solute carrier family 41 member 1

affects expression

Orphenadrine affects the expression of SLC41A1 mRNA

NCBI chr13:43,270,792...43,291,162
Ensembl chr13:43,270,792...43,291,162

G

solute carrier family 6 member 8

affects expression

Orphenadrine affects the expression of SLC6A8 mRNA

NCBI chr X:151,384,675...151,393,979
Ensembl chr X:151,384,675...151,393,979

G

solute carrier family 7, member 4

affects expression

Orphenadrine affects the expression of SLC7A4 mRNA

NCBI chr11:83,435,093...83,439,078
Ensembl chr11:83,435,211...83,438,881

G

solute carrier family 9 member A7

affects expression

Orphenadrine affects the expression of SLC9A7 mRNA

NCBI chr X:2,214,064...2,395,052
Ensembl chr X:2,214,441...2,388,012

G

SMAD family member 6

affects expression

Orphenadrine affects the expression of SMAD6 mRNA

NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763

G

smoothelin-like 2

affects expression

Orphenadrine affects the expression of SMTNL2 mRNA

NCBI chr10:57,008,322...57,029,505
Ensembl chr10:57,008,327...57,029,505

G

sorting nexin 10

affects expression

Orphenadrine affects the expression of SNX10 mRNA

NCBI chr 4:80,612,648...80,677,005
Ensembl chr 4:80,612,669...80,676,996

G

sortilin 1

affects expression

Orphenadrine affects the expression of SORT1 mRNA

NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354

G

SRY-box transcription factor 18

affects expression

Orphenadrine affects the expression of SOX18 mRNA

NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290

G

SRY-box transcription factor 4

affects expression

Orphenadrine affects the expression of SOX4 mRNA

NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665

G

SPC25 component of NDC80 kinetochore complex

affects expression

Orphenadrine affects the expression of SPC25 mRNA

NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959

G

Spetex-2C protein

affects expression

Orphenadrine affects the expression of SPETEX2C mRNA

NCBI chr15:4,779,251...4,781,549
Ensembl chr15:4,779,229...4,781,731

G

Spetex-2F protein

affects expression

Orphenadrine affects the expression of SPETEX2F mRNA

NCBI chr15:17,716,315...17,720,203
Ensembl chr15:17,716,358...17,733,744

G

Spetex-2G protein

affects expression

Orphenadrine affects the expression of SPETEX2G mRNA

NCBI chr15:4,615,554...4,619,166
Ensembl chr15:4,615,466...4,662,812

G

serine peptidase inhibitor, Kazal type 9

affects expression

Orphenadrine affects the expression of SPINK9 mRNA

NCBI chr18:36,427,043...36,430,271
Ensembl chr18:36,426,989...36,430,271

G

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2

affects expression

Orphenadrine affects the expression of SPOCK2 mRNA

NCBI chr20:28,037,334...28,064,272
Ensembl chr20:28,033,475...28,064,272

G

SRC kinase signaling inhibitor 1

affects expression

Orphenadrine affects the expression of SRCIN1 mRNA

NCBI chr10:82,502,911...82,569,882
Ensembl chr10:82,504,393...82,571,040

G

steroid 5 alpha-reductase 1

affects expression

Orphenadrine affects the expression of SRD5A1 mRNA

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

G

SH3 and cysteine rich domain 3

affects expression

Orphenadrine affects the expression of STAC3 mRNA

NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589

G

StAR-related lipid transfer domain containing 9

affects expression

Orphenadrine affects the expression of STARD9 mRNA

NCBI chr 3:107,581,097...107,672,746
Ensembl chr 3:107,581,164...107,673,898

G

syntaxin binding protein 1

affects expression

Orphenadrine affects the expression of STXBP1 mRNA

NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369

G

sulfotransferase family 1E member 1

affects expression

Orphenadrine affects the expression of SULT1E1 mRNA

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

synapse defective Rho GTPase homolog 1

affects expression

Orphenadrine affects the expression of SYDE1 mRNA

NCBI chr 7:11,032,931...11,038,917
Ensembl chr 7:11,032,898...11,039,869

G

synaptic Ras GTPase activating protein 1

affects expression

Orphenadrine affects the expression of SYNGAP1 mRNA

NCBI chr20:5,026,366...5,056,659
Ensembl chr20:5,026,364...5,056,672

G

synaptojanin 2

affects expression

Orphenadrine affects the expression of SYNJ2 mRNA

NCBI chr 1:46,518,594...46,621,919
Ensembl chr 1:46,518,709...46,633,687

G

synemin

affects expression

Orphenadrine affects the expression of SYNM mRNA

NCBI chr 1:121,333,712...121,363,652
Ensembl chr 1:121,333,720...121,363,652

G

tubulin folding cofactor E-like

affects expression

Orphenadrine affects the expression of TBCEL mRNA

NCBI chr 8:42,795,648...42,854,552
Ensembl chr 8:42,796,730...42,854,552

G

TEA domain transcription factor 2

affects expression

Orphenadrine affects the expression of TEAD2 mRNA

NCBI chr 1:95,702,366...95,719,186
Ensembl chr 1:95,703,005...95,719,186

G

teneurin transmembrane protein 2

affects expression

Orphenadrine affects the expression of TENM2 mRNA

NCBI chr10:20,480,662...21,706,415
Ensembl chr10:20,481,854...21,705,597

G

testis expressed 13B

affects expression

Orphenadrine affects the expression of TEX13B mRNA

NCBI chr X:104,490,937...104,511,224
Ensembl chr X:104,490,091...104,494,201

G

testis expressed 36

affects expression

Orphenadrine affects the expression of TEX36 mRNA

NCBI chr 1:188,390,062...188,404,448
Ensembl chr 1:188,390,064...188,404,377

G

thioesterase superfamily member 6

affects expression

Orphenadrine affects the expression of THEM6 mRNA

NCBI chr 7:106,606,570...106,609,747
Ensembl chr 7:106,606,570...106,609,746

G

TRAF-interacting protein with forkhead-associated domain

affects expression

Orphenadrine affects the expression of TIFA mRNA

NCBI chr 2:216,257,926...216,267,635
Ensembl chr 2:216,234,774...216,267,841

G

TLC domain containing 4

affects expression

Orphenadrine affects the expression of TLCD4 mRNA

NCBI chr 2:209,284,873...209,360,156
Ensembl chr 2:209,289,732...209,341,353

G

talin rod domain containing 1

affects expression

Orphenadrine affects the expression of TLNRD1 mRNA

NCBI chr 1:137,864,340...137,866,359
Ensembl chr 1:137,864,343...137,866,359

G

transmembrane BAX inhibitor motif containing 1

affects expression

Orphenadrine affects the expression of TMBIM1 mRNA

NCBI chr 9:75,871,835...75,889,366
Ensembl chr 9:75,871,835...75,889,069

G

transmembrane protein 184B

affects expression

Orphenadrine affects the expression of TMEM184B mRNA

NCBI chr 7:110,925,092...110,967,975
Ensembl chr 7:110,925,092...110,967,943

G

transmembrane protein 184C

affects expression

Orphenadrine affects the expression of TMEM184C mRNA

NCBI chr19:30,345,183...30,361,275
Ensembl chr19:30,345,290...30,361,269

G

transmembrane protein 200B

affects expression

Orphenadrine affects the expression of TMEM200B mRNA

NCBI chr 5:144,107,795...144,110,551
Ensembl chr 5:144,103,550...144,112,506

G

TNF alpha induced protein 2

affects expression

Orphenadrine affects the expression of TNFAIP2 mRNA

NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914

G

TNF receptor superfamily member 11B

affects expression

Orphenadrine affects the expression of TNFRSF11B mRNA

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 12A

affects expression

Orphenadrine affects the expression of TNFRSF12A mRNA

NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045

G

tyrosine kinase, non-receptor, 1

affects expression

Orphenadrine affects the expression of TNK1 mRNA

NCBI chr10:54,571,396...54,580,547
Ensembl chr10:54,571,117...54,579,940

G

tensin 1

affects expression

Orphenadrine affects the expression of TNS1 mRNA

NCBI chr 9:75,491,886...75,702,853
Ensembl chr 9:75,495,814...75,703,225

G

TOG array regulator of axonemal microtubules 2

affects expression

Orphenadrine affects the expression of TOGARAM2 mRNA

NCBI chr 6:23,770,979...23,828,884
Ensembl chr 6:23,771,052...23,828,499

G

TOX high mobility group box family member 3

affects expression

Orphenadrine affects the expression of TOX3 mRNA

NCBI chr19:16,648,338...16,757,151
Ensembl chr19:16,648,342...16,757,148

G

tropomyosin 1

affects expression

Orphenadrine affects the expression of TPM1 mRNA

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

G

Tnf receptor associated factor 4

affects expression

Orphenadrine affects the expression of TRAF4 mRNA

NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284

G

tripartite motif-containing 36

affects expression

Orphenadrine affects the expression of TRIM36 mRNA

NCBI chr18:38,859,604...38,912,859
Ensembl chr18:38,861,018...38,912,859

G

tripartite motif-containing 54

affects expression

Orphenadrine affects the expression of TRIM54 mRNA

NCBI chr 6:25,239,340...25,258,511
Ensembl chr 6:25,239,340...25,258,511

G

transient receptor potential cation channel, subfamily M, member 2

affects expression

Orphenadrine affects the expression of TRPM2 mRNA

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

G

transient receptor potential cation channel, subfamily V, member 2

affects expression

Orphenadrine affects the expression of TRPV2 mRNA

NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260

G

TSC22 domain family, member 3

affects expression

Orphenadrine affects the expression of TSC22D3 mRNA

NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861

G

alpha tocopherol transfer protein like

affects expression

Orphenadrine affects the expression of TTPAL mRNA

NCBI chr 3:152,278,246...152,296,550
Ensembl chr 3:152,278,303...152,296,513

G

ubiquitin-like modifier activating enzyme 7

affects expression

Orphenadrine affects the expression of UBA7 mRNA

NCBI chr 8:108,665,289...108,674,097
Ensembl chr 8:108,665,292...108,674,099

G

UDP glucuronosyltransferase family 2 member A3

affects expression

Orphenadrine affects the expression of UGT2A3 mRNA

NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729

G

UDP glucuronosyltransferase 2 family, polypeptide B1

affects expression

Orphenadrine affects the expression of UGT2B1 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

unc-5 netrin receptor B

affects expression

Orphenadrine affects the expression of UNC5B mRNA

NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537

G

unk like zinc finger

affects expression

Orphenadrine affects the expression of UNKL mRNA

NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225

G

uridine phosphorylase 2

affects expression

Orphenadrine affects the expression of UPP2 mRNA

NCBI chr 3:43,273,048...43,317,417
Ensembl chr 3:43,273,048...43,317,417

G

ubiquitin specific peptidase 18

affects expression

Orphenadrine affects the expression of USP18 mRNA

NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144

G

integral membrane transport protein UST4r

affects expression

Orphenadrine affects the expression of UST4R mRNA

NCBI chr 1:205,072,204...205,142,718
Ensembl chr 1:205,072,296...205,142,691

G

vav guanine nucleotide exchange factor 2

affects expression

Orphenadrine affects the expression of VAV2 mRNA

NCBI chr 3:10,584,688...10,754,128
Ensembl chr 3:10,584,688...10,754,052

G

vasoactive intestinal peptide receptor 1

affects expression

Orphenadrine affects the expression of VIPR1 mRNA

NCBI chr 8:121,303,739...121,339,587
Ensembl chr 8:121,310,248...121,339,585

G

vanin 1

affects expression

Orphenadrine affects the expression of VNN1 mRNA

NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395

G

vomeronasal 2 receptor, 3

affects expression

Orphenadrine affects the expression of VOM2R3 mRNA

NCBI chr 1:76,909...85,784
Ensembl chr 1:76,834...358,271

G

WAP four-disulfide core domain 1

affects expression

Orphenadrine affects the expression of WFDC1 mRNA

NCBI chr19:47,720,191...47,739,121
Ensembl chr19:47,720,423...47,739,108

G

WAS/WASL interacting protein family, member 3

affects expression

Orphenadrine affects the expression of WIPF3 mRNA

NCBI chr 4:83,550,075...83,629,929
Ensembl chr 4:83,550,468...83,629,386

G

X-prolyl aminopeptidase 2

affects expression

Orphenadrine affects the expression of XPNPEP2 mRNA

NCBI chr X:127,287,765...127,317,036
Ensembl chr X:127,287,979...127,317,223

G

zinc finger and BTB domain containing 10

affects expression

Orphenadrine affects the expression of ZBTB10 mRNA

NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515

G

zinc finger and BTB domain containing 42

affects expression

Orphenadrine affects the expression of ZBTB42 mRNA

NCBI chr 6:131,734,257...131,742,459
Ensembl chr 6:131,738,356...131,742,685

G

zinc finger, C2HC-type containing 1A

affects expression

Orphenadrine affects the expression of ZC2HC1A mRNA

NCBI chr 2:94,287,352...94,324,655
Ensembl chr 2:94,287,354...94,324,882

G

zinc finger DHHC-type palmitoyltransferase 8

affects expression

Orphenadrine affects the expression of ZDHHC8 mRNA

NCBI chr11:82,755,110...82,769,280
Ensembl chr11:82,755,143...82,767,734

G

zinc finger protein 319

affects expression

Orphenadrine affects the expression of ZFP319 mRNA

NCBI chr19:9,702,827...9,706,806
Ensembl chr19:9,702,144...9,713,198

G

zinc finger protein 334

affects expression

Orphenadrine affects the expression of ZFP334 mRNA

NCBI chr 3:154,112,537...154,125,087
Ensembl chr 3:154,113,561...154,125,057

G

zinc finger protein 354A

affects expression

Orphenadrine affects the expression of ZFP354A mRNA

NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068

G

zinc finger protein 36

affects expression

Orphenadrine affects the expression of ZFP36 mRNA

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

G

zinc finger protein 36, C3H type-like 2

affects expression

Orphenadrine affects the expression of ZFP36L2 mRNA

NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064

G

zinc finger protein 503

affects expression

Orphenadrine affects the expression of ZFP503 mRNA

NCBI chr15:2,313,060...2,316,848
Ensembl chr15:2,313,060...2,316,848

G

zinc finger protein 668

affects expression

Orphenadrine affects the expression of ZFP668 mRNA

NCBI chr 1:182,474,633...182,484,957
Ensembl chr 1:182,474,633...182,492,878

pergolide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]
Pergolide inhibits the reaction [Levodopa results in increased expression of BAX protein]

PMID:15081873 PMID:15672541

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

dopamine receptor D1

increases activity

Pergolide results in increased activity of DRD1 protein

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

increases activity

Pergolide results in increased activity of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

glial cell derived neurotrophic factor

increases expression
increases secretion

Pergolide results in increased expression of GDNF mRNA
Pergolide results in increased secretion of GDNF protein

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

potassium voltage-gated channel subfamily A member 5

decreases activity

Pergolide results in decreased activity of KCNA5 protein

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

G

potassium calcium-activated channel subfamily M alpha 1

decreases activity

Pergolide results in decreased activity of KCNMA1 protein

NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198

G

mutS homolog 2

multiple interactions

Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

nuclear factor kappa B subunit 1

multiple interactions

Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of NFKB1 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nerve growth factor

increases expression
increases secretion

Pergolide results in increased expression of NGF mRNA
Pergolide results in increased secretion of NGF protein

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of RELA protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 2

multiple interactions

Pergolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

tumor protein p53

multiple interactions

Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]
Pergolide inhibits the reaction [Levodopa results in increased expression of TRP53 protein]

PMID:15081873 PMID:15672541

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

pimozide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2, apoptosis regulator

decreases expression

Pimozide results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

istradefylline inhibits the reaction [Pimozide results in increased expression of FOS protein]; Tropicamide promotes the reaction [Pimozide results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

potassium voltage-gated channel subfamily A member 10

multiple interactions

Pimozide inhibits the reaction [KCNA10 protein results in increased transport of Potassium]

NCBI chr 2:194,786,500...194,798,575
Ensembl chr 2:194,786,500...194,798,575

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

Pimozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Pimozide results in decreased activity of KCNH2 protein

PMID:15671647 PMID:19583963 PMID:21158687 PMID:24052561

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

luteinizing hormone subunit beta

multiple interactions

Pimozide results in decreased secretion of and results in decreased glycosylation of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

prolactin

increases expression

Pimozide results in increased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

pramipexole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

ATP synthase F1 subunit alpha

multiple interactions

Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of ATP5F1A protein]

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

caspase 3

multiple interactions

pramipexole inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

dopamine receptor D2

multiple interactions

pramipexole binds to and results in increased activity of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

multiple interactions

pramipexole binds to and results in increased activity of DRD3 protein

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

mitogen-activated protein kinase 8

multiple interactions

pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

PPARG coactivator 1 alpha

increases expression

Pramipexole results in increased expression of PPARGC1A protein

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein tyrosine phosphatase, receptor type, D

increases expression

[Pramipexole cotreated with exercise] increases expression of Ptprd protein in the striatum

RGD

NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396

G

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions

Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of SDHB protein]

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

pridinol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

pridinol results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

solute carrier family 22 member 2

multiple interactions

pridinol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

procyclidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Procyclidine results in decreased activity of ABCB4 protein

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

bone morphogenetic protein 6

increases expression

Procyclidine results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

epiregulin

increases expression

Procyclidine results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

interleukin 1 alpha

increases expression

Procyclidine results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

Procyclidine results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

increases expression

Procyclidine results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Procyclidine results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

phosphotyrosine interaction domain containing 1

increases expression

Procyclidine results in increased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

prostaglandin-endoperoxide synthase 2

increases expression

Procyclidine results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

solute carrier family 22 member 2

multiple interactions

Procyclidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 7 member 11

increases expression

Procyclidine results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

secretory leukocyte peptidase inhibitor

increases expression

Procyclidine results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

TNF alpha induced protein 6

increases expression

Procyclidine results in increased expression of TNFAIP6 mRNA

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

profenamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

decreases activity
multiple interactions

profenamine results in decreased activity of BCHE protein
profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]

PMID:18656440 PMID:22407886 PMID:28299395 PMID:32278739 PMID:32795450

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

potassium voltage-gated channel subfamily H member 2

decreases activity

profenamine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

ropinirole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2, apoptosis regulator

increases expression

ropinirole results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions

ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

dopamine receptor D2

multiple interactions

ropinirole binds to and results in increased activity of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

multiple interactions

ropinirole binds to and results in increased activity of DRD3 protein

PMID:18242171 PMID:18393062

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

multiple interactions

ropinirole binds to and results in increased activity of DRD4 protein

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

early growth response 1

decreases expression

ropinirole results in decreased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

interleukin 1 beta

multiple interactions

ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ropinirole inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

mitogen activated protein kinase 1

increases phosphorylation

ropinirole results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

ropinirole results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

tumor necrosis factor

multiple interactions

ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

tolcapone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arylacetamide deacetylase

decreases expression

tolcapone results in decreased expression of AADAC mRNA

NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734

G

alanyl-tRNA synthetase 1

increases expression

Tolcapone results in increased expression of AARS1 mRNA

NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147

G

ATP binding cassette subfamily B member 11

decreases activity

tolcapone results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily D member 2

affects binding

tolcapone binds to ABCD2 protein

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

abhydrolase domain containing 10, depalmitoylase

affects binding

tolcapone binds to ABHD10 protein

NCBI chr11:55,081,273...55,095,044
Ensembl chr11:55,081,049...55,107,866

G

acetyl-CoA acetyltransferase 2

increases expression

tolcapone results in increased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

acyl-CoA oxidase 3, pristanoyl

affects binding

tolcapone binds to ACOX3 protein

NCBI chr14:75,133,986...75,176,767
Ensembl chr14:75,094,676...75,176,205

G

acyl-CoA synthetase long-chain family member 1

affects binding
decreases expression

tolcapone binds to ACSL1 protein
tolcapone results in decreased expression of ACSL1 mRNA; tolcapone results in decreased expression of ACSL1 protein

PMID:19783845 PMID:29688484

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase long-chain family member 5

decreases expression

tolcapone results in decreased expression of ACSL5 protein

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

acyl-CoA synthetase short-chain family member 2

increases expression

tolcapone results in increased expression of ACSS2 mRNA

NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675

G

actin alpha 2, smooth muscle

affects binding

tolcapone binds to ACTA2 protein

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

ADP-ribosylhydrolase like 1

affects binding

tolcapone binds to ADPRHL1 protein

NCBI chr16:76,283,186...76,315,075
Ensembl chr16:76,283,103...76,354,440

G

aspartylglucosaminidase

decreases expression

tolcapone results in decreased expression of AGA mRNA

NCBI chr16:38,504,661...38,516,607
Ensembl chr16:38,504,663...38,516,606

G

allograft inflammatory factor 1

decreases expression

tolcapone results in decreased expression of AIF1 mRNA

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

adenylate kinase 2

affects binding

tolcapone binds to AK2 protein

NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632

G

aldo-keto reductase family 1, member C1

affects binding

Tolcapone binds to AKR1C1 protein

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C3

decreases expression

tolcapone results in decreased expression of AKR1C3 mRNA

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

aldo-keto reductase family 1, member D1

affects binding

tolcapone binds to AKR1D1 protein

NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372

G

aldehyde dehydrogenase 18 family, member A1

affects binding

tolcapone binds to ALDH18A1 protein

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldehyde dehydrogenase 1 family, member B1

affects binding

tolcapone binds to ALDH1B1 protein

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 1 family, member L1

increases expression

tolcapone results in increased expression of ALDH1L1 mRNA

NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465

G

aldehyde dehydrogenase 3 family, member A2

affects binding

tolcapone binds to ALDH3A2 protein

NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281

G

ALG13, UDP-N-acetylglucosaminyltransferase subunit

decreases expression

Tolcapone results in decreased expression of ALG13 mRNA

NCBI chr X:107,906,320...107,968,232
Ensembl chr X:107,885,093...107,942,695

G

autocrine motility factor receptor

increases expression

tolcapone results in increased expression of AMFR mRNA

NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247

G

adipocyte plasma membrane associated protein

affects binding

tolcapone binds to APMAP protein

NCBI chr 3:139,409,021...139,437,296
Ensembl chr 3:139,409,022...139,437,341

G

apolipoprotein A1

affects binding

tolcapone binds to APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein B

decreases expression
decreases secretion

tolcapone results in decreased expression of APOB mRNA
tolcapone results in decreased secretion of APOB protein alternative form

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein C2

decreases expression

tolcapone results in decreased expression of APOC2 mRNA

NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476

G

apolipoprotein E

affects binding

tolcapone binds to APOE protein

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

apolipoprotein O-like

decreases expression

tolcapone results in decreased expression of APOOL mRNA

NCBI chr X:77,377,723...77,443,672
Ensembl chr X:77,377,781...77,443,900

G

ADP-ribosylation factor 4

affects binding

tolcapone binds to ARF4 protein

NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261

G

ADP-ribosylation factor like GTPase 1

affects binding

tolcapone binds to ARL1 protein

NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898

G

ATPase family, AAA domain containing 1

affects binding

tolcapone binds to ATAD1 protein

NCBI chr 1:230,544,227...230,610,524
Ensembl chr 1:230,544,047...230,596,548

G

ATPase family, AAA domain containing 3A

affects binding

tolcapone binds to ATAD3A protein

NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482

G

activating transcription factor 5

increases expression

tolcapone results in increased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

ATPase Na+/K+ transporting subunit beta 3

affects binding

tolcapone binds to ATP1B3 protein

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598

G

ATP synthase F1 subunit beta

affects binding

tolcapone binds to ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase F1 subunit gamma

affects binding

Tolcapone binds to ATP5F1C protein

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367

G

ATP synthase F1 subunit epsilon

decreases expression

tolcapone results in decreased expression of ATP5F1E mRNA

NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450

G

ATP synthase membrane subunit e

decreases expression
affects binding

tolcapone results in decreased expression of ATP5ME mRNA
tolcapone binds to ATP5ME protein

PMID:19783845 PMID:24136188

NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013

G

ATP synthase membrane subunit f

affects binding

tolcapone binds to ATP5MF protein

NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236

G

ATP synthase membrane subunit G

decreases expression
affects binding

tolcapone results in decreased expression of ATP5MG mRNA
tolcapone binds to ATP5MG protein

PMID:19783845 PMID:24136188

NCBI chr 8:45,225,680...45,233,630
Ensembl chr 8:45,225,686...45,233,559

G

ATP synthase membrane subunit K

decreases expression

Tolcapone results in decreased expression of ATP5MK mRNA

NCBI chr 1:245,973,910...245,980,702
Ensembl chr 1:245,973,914...245,980,761
Ensembl chr10:245,973,914...245,980,761

G

ATP synthase peripheral stalk subunit F6

decreases expression

tolcapone results in decreased expression of ATP5PF mRNA

NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119

G

ATP synthase peripheral stalk subunit OSCP

affects binding

tolcapone binds to ATP5PO protein

NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592

G

AU RNA binding methylglutaconyl-CoA hydratase

affects binding

tolcapone binds to AUH protein

NCBI chr17:12,329,522...12,424,882
Ensembl chr17:12,329,524...12,424,896

G

gamma-butyrobetaine hydroxylase 1

decreases expression

tolcapone results in decreased expression of BBOX1 mRNA

NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458

G

basal cell adhesion molecule (Lutheran blood group)

affects binding

tolcapone binds to BCAM protein

NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403

G

B-cell receptor-associated protein 29

decreases expression

tolcapone results in decreased expression of BCAP29 mRNA

NCBI chr 6:48,182,702...48,222,698
Ensembl chr 6:48,182,706...48,222,720

G

BCAS2, pre-mRNA processing factor

decreases expression

tolcapone results in decreased expression of BCAS2 mRNA

NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389

G

bridge-like lipid transfer protein family member 1

increases expression

Tolcapone results in increased expression of BLTP1 mRNA

NCBI chr 2:119,708,114...119,924,697
Ensembl chr 2:119,708,209...119,924,695

G

BMP-binding endothelial regulator

affects binding

tolcapone binds to BMPER protein

NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256

G

BMS1 ribosome biogenesis factor

affects binding

tolcapone binds to BMS1 protein

NCBI chr 4:151,558,163...151,595,187
Ensembl chr 4:151,558,163...151,595,127

G

bisphosphoglycerate mutase

decreases expression

tolcapone results in decreased expression of BPGM mRNA

NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581

G

basic transcription factor 3-like 4

decreases expression

tolcapone results in decreased expression of BTF3L4 mRNA

NCBI chr 5:123,567,902...123,587,527
Ensembl chr 5:123,567,907...123,586,866

G

C1D nuclear receptor corepressor

decreases expression

tolcapone results in decreased expression of C1D mRNA

NCBI chr14:91,660,951...91,673,177
Ensembl chr14:91,660,989...91,672,852

G

C1GALT1-specific chaperone 1

decreases expression

tolcapone results in decreased expression of C1GALT1C1 mRNA

NCBI chr X:117,378,123...117,382,620
Ensembl chr X:117,375,525...117,382,787

G

complement C4B

increases expression

tolcapone results in increased expression of C4B mRNA

NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681

G

complement C5

increases expression

tolcapone results in increased expression of C5 mRNA

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

complement C8 alpha chain

increases expression

tolcapone results in increased expression of C8A mRNA

NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754

G

similar to human chromosome 11 open reading frame 71

decreases expression

Tolcapone results in decreased expression of C8H11ORF71 mRNA

NCBI chr 8:48,838,556...48,838,970
Ensembl chr 8:48,838,100...48,842,270

G

similar to human chromosome 15 open reading frame 61

decreases expression

Tolcapone results in decreased expression of C8H15ORF61 mRNA

NCBI chr 8:63,868,125...63,872,863
Ensembl chr 8:63,868,125...63,872,751

G

carbonyl reductase 4

decreases expression

tolcapone results in decreased expression of CBR4 mRNA

NCBI chr16:28,629,928...28,684,230
Ensembl chr16:28,617,224...28,645,712

G

cyclin L2

increases expression

tolcapone results in increased expression of CCNL2 mRNA

NCBI chr 5:166,416,940...166,428,997
Ensembl chr 5:166,417,508...166,436,882

G

chaperonin containing TCP1 subunit 7

affects binding

tolcapone binds to CCT7 protein

NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580

G

CD36 molecule

increases expression

tolcapone results in increased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

complement factor B

increases expression

tolcapone results in increased expression of CFB mRNA

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

coiled-coil-helix-coiled-coil-helix domain containing 1

decreases expression

tolcapone results in decreased expression of CHCHD1 mRNA

NCBI chr15:3,592,719...3,593,901
Ensembl chr15:3,592,727...3,593,901

G

coiled-coil-helix-coiled-coil-helix domain containing 7

decreases expression

tolcapone results in decreased expression of CHCHD7 mRNA

NCBI chr 5:16,957,127...16,961,682
Ensembl chr 5:16,957,188...16,961,184

G

chromatin accessibility complex subunit 1

decreases expression

tolcapone results in decreased expression of CHRAC1 mRNA

NCBI chr 7:105,013,047...105,016,435
Ensembl chr 7:105,013,015...105,017,136

G

churchill domain containing 1

decreases expression

tolcapone results in decreased expression of CHURC1 mRNA

NCBI chr 6:95,464,488...95,485,208
Ensembl chr 6:95,470,683...95,619,586

G

cytosolic iron-sulfur assembly component 2A

decreases expression

tolcapone results in decreased expression of CIAO2A mRNA

NCBI chr 8:66,670,533...66,682,455
Ensembl chr 8:66,670,483...66,682,455

G

cell death-inducing DFFA-like effector a

increases expression

tolcapone results in increased expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

CDGSH iron sulfur domain 1

affects binding

tolcapone binds to CISD1 protein

NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924

G

C-type lectin domain family 4, member A3

decreases expression

Tolcapone results in decreased expression of CLEC4A3 mRNA

NCBI chr 4:156,214,030...156,224,818
Ensembl chr 4:156,214,718...156,224,817

G

clathrin heavy chain

affects binding

tolcapone binds to CLTC protein

NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737

G

cornichon family member 4

decreases expression

tolcapone results in decreased expression of CNIH4 mRNA

NCBI chr13:92,910,315...92,926,428
Ensembl chr13:92,910,315...92,927,853

G

COMM domain containing 6

decreases expression

tolcapone results in decreased expression of COMMD6 mRNA

NCBI chr15:78,467,333...78,474,382
Ensembl chr15:78,467,804...78,474,382

G

catechol-O-methyltransferase

decreases activity
multiple interactions
increases methylation
affects binding

tolcapone results in decreased activity of COMT protein
[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]; [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine; tolcapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]
COMT protein results in increased methylation of tolcapone
tolcapone binds to COMT protein

PMID:2089102 PMID:7566641 PMID:7768073 PMID:8821542 PMID:9333106 More...

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

COPI coat complex subunit gamma 1

affects binding

tolcapone binds to COPG1 protein

NCBI chr 4:120,366,540...120,392,502
Ensembl chr 4:120,366,542...120,415,616

G

COPI coat complex subunit gamma 2

decreases expression

tolcapone results in decreased expression of COPG2 mRNA

NCBI chr 4:59,366,086...59,501,591
Ensembl chr 4:59,366,086...59,501,618

G

coenzyme Q10A

decreases expression

tolcapone results in decreased expression of COQ10A mRNA

NCBI chr 7:792,089...798,392
Ensembl chr 7:792,089...800,161

G

coenzyme Q3 methyltransferase

decreases expression

tolcapone results in decreased expression of COQ3 mRNA

NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607

G

cytochrome c oxidase subunit 6C

affects binding
decreases expression

tolcapone binds to COX6C protein
tolcapone results in decreased expression of COX6C mRNA

PMID:19783845 PMID:24136188

NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963

G

cytochrome c oxidase subunit 7A2

decreases expression

tolcapone results in decreased expression of COX7A2 mRNA

NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633

G

cytochrome c oxidase subunit 7B

decreases expression

tolcapone results in decreased expression of COX7B mRNA

NCBI chr X:71,083,486...71,089,733
Ensembl chr X:71,083,456...71,089,732

G

ceruloplasmin

increases expression

tolcapone results in increased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

cAMP responsive element modulator

decreases expression

tolcapone results in decreased expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

cysteine-rich protein 2

increases expression

tolcapone results in increased expression of CRIP2 mRNA

NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065

G

chromosome segregation 1 like

affects binding

tolcapone binds to CSE1L protein

NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865

G

cystatin B

decreases expression

tolcapone results in decreased expression of CSTB mRNA

NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526

G

cytochrome c-1

affects binding

tolcapone binds to CYC1 protein

NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity

tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Tolcapone results in decreased activity of CYP1A1 protein

PMID:18493746 PMID:33814510

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression

tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
tolcapone results in increased expression of CYP1A2 mRNA

PMID:18493746 PMID:24136188

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Tolcapone results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases response to substance

CYP3A4 protein results in increased susceptibility to Tolcapone

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 51

increases expression

tolcapone results in increased expression of CYP51 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

death-associated protein

increases expression

tolcapone results in increased expression of DAP mRNA

NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752

G

dCMP deaminase

affects binding

tolcapone binds to DCTD protein

NCBI chr16:44,066,952...44,098,654
Ensembl chr16:44,055,128...44,098,446

G

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

affects binding

tolcapone binds to DDOST protein

NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413

G

DEAD-box helicase 18

affects binding

tolcapone binds to DDX18 protein

NCBI chr13:32,729,697...32,743,161
Ensembl chr13:32,729,700...32,743,161

G

24-dehydrocholesterol reductase

affects binding
increases expression

tolcapone binds to DHCR24 protein
tolcapone results in increased expression of DHCR24 mRNA

PMID:19783845 PMID:24136188

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

7-dehydrocholesterol reductase

affects binding

tolcapone binds to DHCR7 protein

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

distal membrane arm assembly component 1

decreases expression

tolcapone results in decreased expression of DMAC1 mRNA

NCBI chr 5:89,241,173...89,243,793
Ensembl chr 5:89,242,661...89,243,757

G

DnaJ heat shock protein family (Hsp40) member C15

decreases expression

tolcapone results in decreased expression of DNAJC15 mRNA

NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675

G

dedicator of cytokinesis 11

decreases expression

tolcapone results in decreased expression of DOCK11 mRNA

NCBI chr X:115,131,720...115,314,854
Ensembl chr X:115,131,909...115,314,854

G

dolichyl-phosphate mannosyltransferase subunit 3, regulatory

decreases expression

tolcapone results in decreased expression of DPM3 mRNA

NCBI chr 2:174,676,532...174,677,047
Ensembl chr 2:174,676,363...174,677,668
Ensembl chr15:174,676,363...174,677,668

G

dpy-30 histone methyltransferase complex regulatory subunit

decreases expression

tolcapone results in decreased expression of DPY30 mRNA

NCBI chr 6:21,120,947...21,141,720
Ensembl chr 6:21,120,947...21,141,432

G

deoxythymidylate kinase

decreases expression

tolcapone results in decreased expression of DTYMK mRNA

NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870

G

dynein light chain LC8-type 1

decreases expression

tolcapone results in decreased expression of DYNLL1 mRNA

NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741

G

dynein light chain Tctex-type 3

decreases expression

tolcapone results in decreased expression of DYNLT3 mRNA

NCBI chr X:13,327,933...13,337,139
Ensembl chr X:13,327,892...13,337,139

G

EBP, cholestenol delta-isomerase

increases expression

tolcapone results in increased expression of EBP mRNA

NCBI chr X:14,299,427...14,305,826
Ensembl chr X:14,299,448...14,305,826

G

enoyl-CoA hydratase, short chain 1

affects binding

tolcapone binds to ECHS1 protein

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

elongin C

decreases expression

tolcapone results in decreased expression of ELOC mRNA

NCBI chr 5:2,661,527...2,677,893
Ensembl chr 5:2,661,724...2,677,890

G

epiregulin

decreases expression

Tolcapone results in decreased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

coagulation factor V

increases expression

tolcapone results in increased expression of F5 mRNA

NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317

G

family with sequence similarity 162, member A

affects binding

tolcapone binds to FAM162A protein

NCBI chr11:64,680,978...64,709,865
Ensembl chr11:64,680,323...64,711,239

G

fibrillarin-like 1

affects binding

tolcapone binds to FBLL1 protein

NCBI chr10:20,258,656...20,260,299
Ensembl chr10:20,258,656...20,260,299

G

Fcf1 rRNA-processing protein

decreases expression

tolcapone results in decreased expression of FCF1 mRNA

NCBI chr 6:104,617,780...104,629,643
Ensembl chr 6:104,617,770...104,629,643

G

fibrinogen alpha chain

affects binding

tolcapone binds to FGA protein

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

formation of mitochondrial complex V assembly factor 1

decreases expression

tolcapone results in decreased expression of FMC1 mRNA

NCBI chr 4:67,274,104...67,282,140
Ensembl chr 4:67,274,104...67,282,140

G

glutaryl-CoA dehydrogenase

affects binding

tolcapone binds to GCDH protein

NCBI chr19:23,263,215...23,269,689
Ensembl chr19:23,263,264...23,269,681

G

golgi glycoprotein 1

affects binding

tolcapone binds to GLG1 protein

NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178

G

glia maturation factor, gamma

decreases expression

tolcapone results in decreased expression of GMFG mRNA

NCBI chr 1:83,728,797...83,739,189
Ensembl chr 1:83,728,776...83,739,183

G

G protein subunit gamma 10

decreases expression

tolcapone results in decreased expression of GNG10 mRNA

NCBI chr 5:73,856,124...73,863,017
Ensembl chr 5:73,856,164...73,863,012
Ensembl chr 5:73,856,164...73,863,012

G

G protein subunit gamma 5

decreases expression

tolcapone results in decreased expression of GNG5 mRNA

NCBI chr 2:235,394,680...235,403,177
Ensembl chr 1:77,292,043...77,292,513

G

glypican 3

affects binding

tolcapone binds to GPC3 protein

NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798

G

general transcription factor IIH subunit 5

decreases expression

tolcapone results in decreased expression of GTF2H5 mRNA

NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939

G

H2A.Z variant histone 2

affects binding

Tolcapone binds to H2AZ2 protein

NCBI chr14:81,293,304...81,312,209
Ensembl chr14:81,293,299...81,312,144

G

hemoglobin subunit beta

affects binding

tolcapone binds to HBB protein

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

HIG1 hypoxia inducible domain family, member 1A

decreases expression

tolcapone results in decreased expression of HIGD1A mRNA

NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443

G

histidine triad nucleotide binding protein 3

decreases expression

tolcapone results in decreased expression of HINT3 mRNA

NCBI chr 1:27,035,936...27,045,799
Ensembl chr 1:27,035,905...27,047,721

G

histone cluster 1 H4 family member B

decreases expression

Tolcapone results in decreased expression of HIST1H4B mRNA

NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370

G

heterogeneous nuclear ribonucleoprotein H1

affects binding

tolcapone binds to HNRNPH1 protein

NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846

G

hydroxysteroid (17-beta) dehydrogenase 11

affects binding

tolcapone binds to HSD17B11 protein

NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161

G

hydroxysteroid (17-beta) dehydrogenase 12

affects binding

tolcapone binds to HSD17B12 protein

NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617

G

hydroxysteroid (17-beta) dehydrogenase 13

affects binding

tolcapone binds to HSD17B13 protein

NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166

G

hydroxysteroid (17-beta) dehydrogenase 4

affects binding

tolcapone binds to HSD17B4 protein

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

hydroxysteroid dehydrogenase like 2

increases expression

tolcapone results in increased expression of HSDL2 mRNA

NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839

G

intraflagellar transport associated protein

decreases expression

Tolcapone results in decreased expression of IFTAP mRNA

NCBI chr 3:87,812,068...87,906,517
Ensembl chr 3:87,817,408...87,906,547

G

insulin-like growth factor binding protein 1

increases expression

tolcapone results in increased expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

interleukin 24

decreases expression

Tolcapone results in decreased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

importin 7

affects binding

tolcapone binds to IPO7 protein

NCBI chr 1:164,062,702...164,102,938
Ensembl chr 1:164,062,702...164,102,938

G

integral membrane protein 2A

affects binding

tolcapone binds to ITM2A protein

NCBI chr X:72,486,383...72,492,344
Ensembl chr X:72,486,381...72,492,363

G

jagunal homolog 1

affects binding

tolcapone binds to JAGN1 protein

NCBI chr 4:146,591,577...146,596,287
Ensembl chr 4:146,591,510...146,596,288

G

potassium voltage-gated channel subfamily H member 2

decreases activity

tolcapone results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

alpha-ketoglutarate dehydrogenase subunit 4

decreases expression

Tolcapone results in decreased expression of KGD4 mRNA

NCBI chr 2:31,870,549...31,878,335
Ensembl chr 2:31,870,551...31,880,730

G

kininogen 1

increases expression

Tolcapone results in increased expression of KNG1 mRNA

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

L antigen family, member 3

decreases expression

tolcapone results in decreased expression of LAGE3 mRNA

NCBI chr X:152,138,209...152,139,632
Ensembl chr X:152,138,218...152,139,632

G

lipopolysaccharide binding protein

increases expression

tolcapone results in increased expression of LBP mRNA

NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586

G

leucine rich repeat containing 59

affects binding

tolcapone binds to LRRC59 protein

NCBI chr10:79,572,295...79,586,953
Ensembl chr10:79,572,317...79,602,533

G

LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

tolcapone results in decreased expression of LSM3 mRNA

NCBI chr 4:124,021,023...124,027,269
Ensembl chr 4:124,021,023...124,027,269

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

tolcapone results in decreased expression of LSM5 mRNA

NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165
Ensembl chr 4:104,652,477...104,654,165

G

LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

tolcapone results in decreased expression of LSM7 mRNA

NCBI chr 7:8,856,698...8,859,113
Ensembl chr 7:8,856,489...8,859,119

G

mago homolog, exon junction complex subunit

decreases expression

tolcapone results in decreased expression of MAGOH mRNA

NCBI chr 5:122,639,268...122,646,650
Ensembl chr 5:122,639,308...122,646,617

G

MBL associated serine protease 1

increases expression

tolcapone results in increased expression of MASP1 mRNA

NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974

G

matrin 3

decreases expression

tolcapone results in decreased expression of MATR3 mRNA

NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166

G

methylmalonyl CoA epimerase

decreases expression

tolcapone results in decreased expression of MCEE mRNA

NCBI chr 1:117,964,576...117,987,779
Ensembl chr 1:117,964,576...117,988,484

G

MCTS1, re-initiation and release factor

decreases expression

tolcapone results in decreased expression of MCTS1 mRNA

NCBI chr X:117,350,723...117,362,504
Ensembl chr X:117,350,889...117,362,504

G

mediator complex subunit 21

decreases expression

tolcapone results in decreased expression of MED21 mRNA

NCBI chr 4:179,560,509...179,583,811
Ensembl chr 4:179,560,579...179,567,548

G

mediator complex subunit 28

decreases expression

tolcapone results in decreased expression of MED28 mRNA

NCBI chr14:65,594,785...65,603,583
Ensembl chr14:65,594,647...65,603,583

G

mediator complex subunit 31

decreases expression

tolcapone results in decreased expression of MED31 mRNA

NCBI chr10:56,836,944...56,840,326
Ensembl chr10:56,836,944...56,840,326

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Tolcapone results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

methyltransferase 5, N6-adenosine

decreases expression

tolcapone results in decreased expression of METTL5 mRNA

NCBI chr 3:54,625,790...54,638,066
Ensembl chr 3:54,625,793...54,638,039

G

major facilitator superfamily domain containing 5

decreases expression

tolcapone results in decreased expression of MFSD5 mRNA

NCBI chr 7:133,409,096...133,411,377
Ensembl chr 7:133,402,537...133,411,396

G

microsomal glutathione S-transferase 1

affects binding

tolcapone binds to MGST1 protein

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

MIA SH3 domain ER export factor 3

decreases expression

tolcapone results in decreased expression of MIA3 mRNA

NCBI chr13:94,970,421...95,012,071
Ensembl chr13:94,970,424...95,011,972

G

MKKS centrosomal shuttling protein

decreases expression

tolcapone results in decreased expression of MKKS mRNA

NCBI chr 3:124,201,877...124,221,142
Ensembl chr 3:124,201,877...124,220,162

G

makorin ring finger protein 1

decreases expression

tolcapone results in decreased expression of MKRN1 mRNA

NCBI chr 4:68,175,908...68,197,216
Ensembl chr 4:68,175,909...68,197,165

G

metabolism of cobalamin associated D

decreases expression

tolcapone results in decreased expression of MMADHC mRNA

NCBI chr 3:34,708,649...34,726,554
Ensembl chr 3:34,708,649...34,726,771

G

mitochondrial ribosomal protein L1

decreases expression

tolcapone results in decreased expression of MRPL1 mRNA

NCBI chr14:13,300,522...13,359,654
Ensembl chr14:13,300,522...13,359,721

G

mitochondrial ribosomal protein L13

decreases expression

tolcapone results in decreased expression of MRPL13 mRNA

NCBI chr 7:86,951,541...86,973,147
Ensembl chr 7:86,951,541...86,973,577

G

mitochondrial ribosomal protein L14

decreases expression

tolcapone results in decreased expression of MRPL14 mRNA

NCBI chr 9:15,302,840...15,315,195
Ensembl chr 9:15,302,427...15,315,267

G

mitochondrial ribosomal protein L18

decreases expression

tolcapone results in decreased expression of MRPL18 mRNA

NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987

G

mitochondrial ribosomal protein L20

decreases expression

tolcapone results in decreased expression of MRPL20 mRNA

NCBI chr 5:166,408,962...166,413,492
Ensembl chr 5:166,408,962...166,413,492

G

mitochondrial ribosomal protein L22

decreases expression

tolcapone results in decreased expression of MRPL22 mRNA

NCBI chr10:42,345,446...42,355,779
Ensembl chr10:42,342,776...42,355,779

G

mitochondrial ribosomal protein L23

decreases expression

tolcapone results in decreased expression of MRPL23 mRNA

NCBI chr 1:197,687,452...197,695,222
Ensembl chr 1:197,687,347...197,695,222

G

mitochondrial ribosomal protein L30

decreases expression

tolcapone results in decreased expression of MRPL30 mRNA

NCBI chr 9:40,125,352...40,136,189
Ensembl chr 9:40,125,430...40,137,257

G

mitochondrial ribosomal protein L32

decreases expression

tolcapone results in decreased expression of MRPL32 mRNA

NCBI chr17:50,565,133...50,568,000
Ensembl chr17:50,565,055...50,568,010

G

mitochondrial ribosomal protein L36

decreases expression

tolcapone results in decreased expression of MRPL36 mRNA

NCBI chr 1:29,965,481...29,968,896
Ensembl chr 1:29,965,317...29,968,807

G

mitochondrial ribosomal protein L40

decreases expression

tolcapone results in decreased expression of MRPL40 mRNA

NCBI chr11:82,133,398...82,139,234
Ensembl chr11:82,133,398...82,139,233

G

mitochondrial ribosomal protein L53

decreases expression

tolcapone results in decreased expression of MRPL53 mRNA

NCBI chr 4:115,615,329...115,616,219

G

mitochondrial ribosomal protein S14

decreases expression

tolcapone results in decreased expression of MRPS14 mRNA

NCBI chr13:72,429,168...72,434,915
Ensembl chr13:72,408,558...72,434,915

G

mitochondrial ribosomal protein S18C

decreases expression

tolcapone results in decreased expression of MRPS18C mRNA

NCBI chr14:8,812,301...8,818,538
Ensembl chr14:8,791,330...8,818,516

G

mitochondrial ribosomal protein S24

decreases expression

tolcapone results in decreased expression of MRPS24 mRNA

NCBI chr14:80,584,671...80,588,801
Ensembl chr14:80,584,673...80,588,871

G

mitochondrial ribosomal protein S33

decreases expression

tolcapone results in decreased expression of MRPS33 mRNA

NCBI chr 4:68,596,729...68,605,547
Ensembl chr 4:68,596,729...68,605,428

G

methylthioadenosine phosphorylase

affects binding

tolcapone binds to MTAP protein

NCBI chr 5:103,874,460...103,920,684
Ensembl chr 5:103,873,020...103,939,406

G

microsomal triglyceride transfer protein

increases expression

tolcapone results in increased expression of MTTP protein

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

mevalonate kinase

increases expression

tolcapone results in increased expression of MVK mRNA

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

G

N(alpha)-acetyltransferase 20, NatB catalytic subunit

decreases expression

tolcapone results in decreased expression of NAA20 mRNA

NCBI chr 3:133,322,036...133,336,843
Ensembl chr 3:133,322,064...133,337,009

G

N-acetyltransferase 10

affects binding

tolcapone binds to NAT10 protein

NCBI chr 3:90,111,643...90,149,891
Ensembl chr 3:90,111,645...90,149,927

G

NADH:ubiquinone oxidoreductase subunit A1

decreases expression

tolcapone results in decreased expression of NDUFA1 mRNA

NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633

G

NADH:ubiquinone oxidoreductase subunit A2

decreases expression

tolcapone results in decreased expression of NDUFA2 mRNA

NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076

G

NADH:ubiquinone oxidoreductase subunit A6

decreases expression

tolcapone results in decreased expression of NDUFA6 mRNA

NCBI chr 7:113,866,382...113,870,239
Ensembl chr 7:113,866,382...113,870,239

G

NADH:ubiquinone oxidoreductase subunit A7

decreases expression

tolcapone results in decreased expression of NDUFA7 mRNA

NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976

G

NADH:ubiquinone oxidoreductase subunit A9

affects binding

tolcapone binds to NDUFA9 protein

NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018

G

NADH:ubiquinone oxidoreductase subunit B6

decreases expression

tolcapone results in decreased expression of NDUFB6 mRNA

NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181

G

NADH:ubiquinone oxidoreductase subunit C2

decreases expression

tolcapone results in decreased expression of NDUFC2 mRNA

NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189

G

NADH:ubiquinone oxidoreductase subunit S4

decreases expression

tolcapone results in decreased expression of NDUFS4 mRNA

NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846

G

NADH:ubiquinone oxidoreductase subunit S5

decreases expression

tolcapone results in decreased expression of NDUFS5 mRNA

NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603

G

NFE2 like bZIP transcription factor 2

decreases expression

tolcapone results in decreased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nipsnap homolog 1

affects binding

tolcapone binds to NIPSNAP1 protein

NCBI chr14:79,734,234...79,758,101
Ensembl chr14:79,734,209...79,758,098

G

nipsnap homolog 2

affects binding

tolcapone binds to NIPSNAP2 protein

NCBI chr12:26,906,068...26,944,201
Ensembl chr12:26,911,723...26,944,166

G

NME/NM23 nucleoside diphosphate kinase 3

decreases expression

tolcapone results in decreased expression of NME3 mRNA

NCBI chr10:13,917,309...13,918,415
Ensembl chr10:13,917,403...13,918,359

G

NOP56 ribonucleoprotein

affects binding

tolcapone binds to NOP56 protein

NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841

G

nephrocystin 1

decreases expression

tolcapone results in decreased expression of NPHP1 mRNA

NCBI chr 3:114,960,650...115,016,234
Ensembl chr 3:114,960,650...115,016,234

G

NPL4 homolog, ubiquitin recognition factor

increases expression

tolcapone results in increased expression of NPLOC4 mRNA

NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

tolcapone results in decreased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear protein 2, transcriptional regulator

decreases expression

tolcapone results in decreased expression of NUPR2 mRNA

NCBI chr12:26,800,123...26,803,228
Ensembl chr12:26,799,800...26,803,304

G

prolyl 4-hydroxylase subunit alpha 1

affects binding

tolcapone binds to P4HA1 protein

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786

G

pyruvate carboxylase

affects binding

tolcapone binds to PC protein

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

proliferating cell nuclear antigen

decreases expression

tolcapone results in decreased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

phosphate cytidylyltransferase 1A, choline

affects binding

tolcapone binds to PCYT1A protein

NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357

G

PDZ domain containing 11

decreases expression

tolcapone results in decreased expression of PDZD11 mRNA

NCBI chr X:65,718,689...65,721,742
Ensembl chr X:65,704,067...65,721,642

G

prefoldin subunit 1

decreases expression

tolcapone results in decreased expression of PFDN1 mRNA

NCBI chr18:28,014,145...28,067,148
Ensembl chr18:28,014,145...28,067,064

G

prefoldin subunit 5

decreases expression

tolcapone results in decreased expression of PFDN5 mRNA

NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516

G

phosphoglucomutase 1

increases expression

tolcapone results in increased expression of PGM1 mRNA

NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728

G

progesterone receptor

multiple interactions

tolcapone binds to and results in decreased activity of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phosphatidylinositol glycan anchor biosynthesis, class P

decreases expression

tolcapone results in decreased expression of PIGP mRNA

NCBI chr11:33,682,943...33,689,111
Ensembl chr11:33,682,948...33,689,321

G

phosphatidylinositol glycan anchor biosynthesis, class S

affects binding

tolcapone binds to PIGS protein

NCBI chr10:63,222,611...63,237,190
Ensembl chr10:63,222,572...63,237,187

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 4

decreases expression

tolcapone results in decreased expression of PIN4 mRNA

NCBI chr X:67,232,066...67,238,709
Ensembl chr X:67,232,081...67,238,702

G

perilipin 2

affects binding

tolcapone binds to PLIN2 protein

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

perilipin 3

affects binding

tolcapone binds to PLIN3 protein

NCBI chr 9:1,111,178...1,123,057
Ensembl chr 9:1,102,366...1,123,147

G

patatin-like phospholipase domain containing 2

increases expression

tolcapone results in increased expression of PNPLA2 mRNA

NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805

G

RNA polymerase I subunit H

decreases expression

Tolcapone results in decreased expression of POLR1H mRNA

NCBI chr20:1,594,936...1,598,854
Ensembl chr20:1,594,936...1,598,854

G

RNA polymerase II subunit G

decreases expression

tolcapone results in decreased expression of POLR2G mRNA

NCBI chr 1:205,689,160...205,692,537
Ensembl chr 1:205,689,160...205,692,686

G

pre-mRNA processing factor 8

affects binding

tolcapone binds to PRPF8 protein

NCBI chr10:60,331,494...60,354,606
Ensembl chr10:60,331,494...60,354,606

G

peroxiredoxin like 2A

affects binding

tolcapone binds to PRXL2A protein

NCBI chr16:16,866,601...16,886,378
Ensembl chr16:16,866,603...16,886,433

G

proteasome 26S subunit, ATPase 5

affects binding

tolcapone binds to PSMC5 protein

NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135

G

proteasome activator subunit 2

affects binding

tolcapone binds to PSME2 protein

NCBI chr15:29,078,495...29,082,794
Ensembl chr15:29,078,500...29,082,946

G

prostaglandin-endoperoxide synthase 2

increases expression

Tolcapone results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

peptidyl-tRNA hydrolase 2

affects binding

tolcapone binds to PTRH2 protein

NCBI chr10:71,505,113...71,515,297
Ensembl chr10:71,504,956...71,515,398

G

RNA guanine-7 methyltransferase activating subunit

decreases expression

tolcapone results in decreased expression of RAMAC mRNA

NCBI chr 1:135,708,529...135,714,417
Ensembl chr 1:135,708,535...135,722,151

G

RAN, member RAS oncogene family

affects binding

tolcapone binds to RAN protein

NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276

G

RAP1A, member of RAS oncogene family

decreases expression

tolcapone results in decreased expression of RAP1A mRNA

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

ribosomal biogenesis factor

decreases expression

Tolcapone results in decreased expression of RBIS mRNA

NCBI chr 2:86,981,314...86,997,352
Ensembl chr 2:86,991,315...87,041,339

G

RNA binding motif protein 8A

decreases expression

tolcapone results in decreased expression of RBM8A mRNA

NCBI chr 2:184,165,189...184,167,959
Ensembl chr 2:184,165,193...184,167,959

G

retinol binding protein 1

decreases expression

tolcapone results in decreased expression of RBP1 mRNA

NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743

G

receptor accessory protein 6

affects binding

tolcapone binds to REEP6 protein

NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597

G

similar to RIKEN cDNA 1110059G10

decreases expression

tolcapone results in decreased expression of RGD1311745 mRNA

NCBI chr 8:122,598,363...122,609,127
Ensembl chr 8:122,598,401...122,609,168

G

ring finger protein 7

decreases expression

tolcapone results in decreased expression of RNF7 mRNA

NCBI chr 8:97,038,845...97,048,080
Ensembl chr 8:97,038,840...97,047,824

G

renalase, FAD-dependent amine oxidase

decreases expression

tolcapone results in decreased expression of RNLS mRNA

NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823

G

reactive oxygen species modulator 1

decreases expression

tolcapone results in decreased expression of ROMO1 mRNA

NCBI chr 3:144,659,709...144,661,310
Ensembl chr 3:144,659,826...144,661,310

G

replication protein A3

decreases expression

tolcapone results in decreased expression of RPA3 mRNA

NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709

G

ribosomal protein L10A

affects binding

tolcapone binds to RPL10A protein

NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357

G

ribosomal protein L15

affects binding

tolcapone binds to RPL15 protein

NCBI chr15:7,503,883...7,507,166
Ensembl chr15:7,503,883...7,507,165

G

ribosomal protein L18A

affects binding

tolcapone binds to RPL18A protein

NCBI chr16:18,542,555...18,544,578
Ensembl chr16:18,542,566...18,545,546

G

ribosomal protein L22

affects binding

tolcapone binds to RPL22 protein

NCBI chr 5:162,835,241...162,843,394
Ensembl chr 5:162,833,740...162,843,368
Ensembl chr 7:162,833,740...162,843,368
Ensembl chr 4:162,833,740...162,843,368

G

ribosomal protein L22 like 1

decreases expression

tolcapone results in decreased expression of RPL22L1 mRNA

NCBI chr 2:111,754,687...111,756,623
Ensembl chr 2:111,754,687...111,756,625

G

ribosomal protein L23

affects binding

tolcapone binds to RPL23 protein

NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870

G

ribosomal protein L35A

decreases expression

tolcapone results in decreased expression of RPL35A mRNA

NCBI chr11:67,726,031...67,729,953
Ensembl chr11:67,726,032...67,729,942
Ensembl chr 5:67,726,032...67,729,942

G

ribosomal protein L36A

decreases expression

tolcapone results in decreased expression of RPL36A mRNA

NCBI chr X:97,766,179...97,768,892
Ensembl chr X:97,766,179...97,768,892

G

ribosomal protein L41

decreases expression

tolcapone results in decreased expression of RPL41 mRNA

NCBI chr 7:977,885...978,965

G

ribosomal protein L7A

affects binding

tolcapone binds to RPL7A protein

NCBI chr 3:10,239,026...10,241,703
Ensembl chr 3:10,239,001...10,241,716

G

ribosomal protein L7-like 1

affects binding

tolcapone binds to RPL7L1 protein

NCBI chr 9:14,198,101...14,206,119
Ensembl chr 9:14,198,092...14,206,110

G

ribosomal protein L9

decreases expression

tolcapone results in decreased expression of RPL9 mRNA

NCBI chr14:42,893,945...42,897,140
Ensembl chr14:42,893,942...42,897,136
Ensembl chr 3:42,893,942...42,897,136

G

ribonuclease P/MRP subunit p21

decreases expression

tolcapone results in decreased expression of RPP21 mRNA

NCBI chr20:2,018,170...2,020,100
Ensembl chr20:2,018,147...2,020,106

G

ribosomal protein S11

affects binding

tolcapone binds to RPS11 protein

NCBI chr 1:95,605,690...95,607,798
Ensembl chr 1:95,605,692...95,607,874

G

ribosomal protein S14

affects binding

tolcapone binds to RPS14 protein

NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166

G

ribosomal protein S15a

decreases expression

tolcapone results in decreased expression of RPS15A mRNA

NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995

G

ribosomal protein S20

affects binding

tolcapone binds to RPS20 protein

NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475

G

ribosomal protein S21, pseudogene 1

decreases expression

tolcapone results in decreased expression of RPS21 mRNA

NCBI chr 5:153,387,133...153,387,476
Ensembl chr 5:153,387,176...153,387,427

G

ribosomal protein S24

decreases expression

tolcapone results in decreased expression of RPS24 mRNA

NCBI chr16:89,538...94,267
Ensembl chr16:89,604...94,279

G

ribosomal protein s25

decreases expression

tolcapone results in decreased expression of RPS25 mRNA

NCBI chr 8:44,733,623...44,735,999
Ensembl chr 8:44,733,029...44,737,271

G

ribosomal protein S27

decreases expression

tolcapone results in decreased expression of RPS27 mRNA

NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964

G

ribosomal protein S27a

affects binding

tolcapone binds to RPS27A protein

NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011

G

S100 calcium binding protein A10

decreases expression

tolcapone results in decreased expression of S100A10 mRNA

NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661

G

sterol-C5-desaturase

increases expression

tolcapone results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

stearoyl-CoA desaturase

affects binding
decreases expression

tolcapone binds to SCD protein
tolcapone results in decreased expression of SCD1 mRNA

PMID:19783845 PMID:24136188

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

succinate dehydrogenase complex flavoprotein subunit A

affects binding

tolcapone binds to SDHA protein

NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535

G

succinate dehydrogenase complex iron sulfur subunit B

affects binding

tolcapone binds to SDHB protein

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

G

SEC11 homolog C, signal peptidase complex subunit

affects binding

tolcapone binds to SEC11C protein

NCBI chr18:59,320,932...59,337,272
Ensembl chr18:59,320,884...59,337,364

G

SEC31 homolog A, COPII coat complex component

affects binding

tolcapone binds to SEC31A protein

NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273

G

Serpine1 mRNA binding protein 1

affects binding

tolcapone binds to SERBP1 protein

NCBI chr 4:96,401,587...96,421,816
Ensembl chr 4:96,401,477...96,421,813

G

splicing factor 3B, subunit 6

affects binding

tolcapone binds to SF3B6 protein

NCBI chr 6:27,826,044...27,835,086
Ensembl chr 6:27,826,029...27,835,156

G

sideroflexin 1

affects binding

tolcapone binds to SFXN1 protein

NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529

G

SIK family kinase 3

increases expression

tolcapone results in increased expression of SIK3 mRNA

NCBI chr 8:46,312,253...46,522,444
Ensembl chr 8:46,311,989...46,522,444

G

solute carrier family 1 member 5

affects binding

tolcapone binds to SLC1A5 protein

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 25 member 1

affects binding

tolcapone binds to SLC25A1 protein

NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781

G

solute carrier family 25 member 13

affects binding

tolcapone binds to SLC25A13 protein

NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902

G

solute carrier family 25 member 4

affects binding

tolcapone binds to SLC25A4 protein

NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733

G

solute carrier family 25 member 5

affects binding

tolcapone binds to SLC25A5 protein

NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967

G

solute carrier family 25 member 6

affects binding

tolcapone binds to SLC25A6 protein

NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199

G

solute carrier family 39 member 7

affects binding

tolcapone binds to SLC39A7 protein

NCBI chr20:4,823,166...4,826,538
Ensembl chr20:4,822,012...4,826,537

G

solute carrier family 7 member 11

decreases expression

Tolcapone results in decreased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

secretory leukocyte peptidase inhibitor

decreases expression

Tolcapone results in decreased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

small integral membrane protein 26

decreases expression

tolcapone results in decreased expression of SMIM26 mRNA

NCBI chr 3:131,990,147...131,991,779
Ensembl chr 3:131,990,291...131,992,132

G

SNAP-associated protein

decreases expression

tolcapone results in decreased expression of SNAPIN mRNA

NCBI chr 2:175,971,575...175,974,164
Ensembl chr 2:175,971,257...175,974,231

G

synuclein alpha

multiple interactions

tolcapone inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

small nuclear ribonucleoprotein U4/U6.U5 subunit 27

decreases expression

Tolcapone results in decreased expression of SNRNP27 mRNA

NCBI chr 4:119,123,676...119,133,234
Ensembl chr 4:119,121,877...119,133,234

G

small nuclear ribonucleoprotein polypeptide B2

decreases expression

tolcapone results in decreased expression of SNRPB2 mRNA

NCBI chr 3:130,399,239...130,408,821
Ensembl chr 3:130,399,248...130,408,812

G

small nuclear ribonucleoprotein D3 polypeptide

decreases expression

tolcapone results in decreased expression of SNRPD3 mRNA

NCBI chr20:13,130,112...13,145,947
Ensembl chr20:13,130,119...13,145,978

G

small nuclear ribonucleoprotein polypeptide E

decreases expression

tolcapone results in decreased expression of SNRPE mRNA

NCBI chr13:45,050,986...45,057,231
Ensembl chr13:45,050,986...45,057,310
Ensembl chr 8:45,050,986...45,057,310

G

small nuclear ribonucleoprotein polypeptide F

decreases expression

tolcapone results in decreased expression of SNRPF mRNA

NCBI chr 7:28,130,427...28,137,129
Ensembl chr 7:28,130,427...28,137,129

G

small nuclear ribonucleoprotein polypeptide G

decreases expression

tolcapone results in decreased expression of SNRPG mRNA

NCBI chr 4:118,812,278...118,819,827
Ensembl chr 4:118,812,252...118,819,826

G

superoxide dismutase 1

decreases expression

tolcapone results in decreased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression

tolcapone results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

signal recognition particle 14

decreases expression

tolcapone results in decreased expression of SRP14 mRNA

NCBI chr 3:105,442,184...105,445,875
Ensembl chr 3:105,442,198...105,445,859

G

SRP receptor subunit beta

affects binding

tolcapone binds to SRPRB protein

NCBI chr 8:103,768,685...103,782,632

G

SS18 like 2

decreases expression

tolcapone results in decreased expression of SS18L2 mRNA

NCBI chr 8:121,375,263...121,377,877
Ensembl chr 8:121,375,308...121,377,877

G

signal sequence receptor subunit 1

affects binding

tolcapone binds to SSR1 protein

NCBI chr17:26,833,720...26,861,821
Ensembl chr17:26,833,741...26,861,821

G

SH3 and cysteine rich domain 3

decreases expression

tolcapone results in decreased expression of STAC3 mRNA

NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589

G

signal transducer and activator of transcription 3

increases expression

tolcapone results in increased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

sulfotransferase family 2A member 1

affects binding

tolcapone binds to SULT2A1 protein

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

TATA-box binding protein associated factor 9

decreases expression

tolcapone results in decreased expression of TAF9 mRNA

NCBI chr 2:31,794,316...31,798,324
Ensembl chr 2:31,794,142...31,798,769

G

tubulin folding cofactor A

decreases expression

tolcapone results in decreased expression of TBCA mRNA

NCBI chr 2:26,011,714...26,065,909
Ensembl chr 2:26,011,795...26,065,907

G

transcription elongation factor A like 8

decreases expression

tolcapone results in decreased expression of TCEAL8 mRNA

NCBI chr X:99,171,307...99,173,377
Ensembl chr X:99,171,177...99,173,710

G

transferrin receptor 2

increases expression

tolcapone results in increased expression of TFR2 mRNA

NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591

G

translocase of inner mitochondrial membrane 10

decreases expression

tolcapone results in decreased expression of TIMM10 mRNA

NCBI chr 3:69,908,397...69,911,943
Ensembl chr 3:69,908,456...69,911,940

G

translocase of inner mitochondrial membrane 44

affects binding

tolcapone binds to TIMM44 protein

NCBI chr12:2,612,581...2,629,374
Ensembl chr12:2,612,581...2,629,351

G

translocase of inner mitochondrial membrane 8 homolog B

decreases expression

tolcapone results in decreased expression of TIMM8B mRNA

NCBI chr 8:50,954,350...50,955,730
Ensembl chr 8:50,954,342...50,955,729

G

thymidine kinase 2

affects binding

tolcapone binds to TK2 protein

NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924

G

TM2 domain containing 1

decreases expression

tolcapone results in decreased expression of TM2D1 mRNA

NCBI chr 5:113,020,793...113,062,134
Ensembl chr 5:113,020,760...113,050,933

G

transmembrane p24 trafficking protein 10

affects binding

tolcapone binds to TMED10 protein

NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753

G

transmembrane p24 trafficking protein 4

affects binding

tolcapone binds to TMED4 protein

NCBI chr14:81,125,049...81,129,646
Ensembl chr14:81,125,053...81,129,631

G

transmembrane p24 trafficking protein 9

affects binding

tolcapone binds to TMED9 protein

NCBI chr17:9,029,646...9,034,160
Ensembl chr17:9,029,646...9,034,176

G

transmembrane protein 126A

decreases expression

tolcapone results in decreased expression of TMEM126A mRNA

NCBI chr 1:144,424,481...144,430,730
Ensembl chr 1:144,422,703...144,430,628

G

transmembrane protein 126B

decreases expression

tolcapone results in decreased expression of TMEM126B mRNA

NCBI chr 1:144,437,142...144,451,508
Ensembl chr 1:144,437,145...144,451,435

G

transmembrane protein 128

decreases expression

tolcapone results in decreased expression of TMEM128 mRNA

NCBI chr14:72,539,530...72,548,623
Ensembl chr14:72,539,532...72,548,550

G

transmembrane protein 203

decreases expression

tolcapone results in decreased expression of TMEM203 mRNA

NCBI chr 3:8,070,904...8,071,732
Ensembl chr 3:8,070,914...8,071,867

G

transmembrane protein 238

decreases expression

tolcapone results in decreased expression of TMEM238 mRNA

NCBI chr 1:69,057,083...69,062,477
Ensembl chr 1:69,056,805...69,076,133

G

transmembrane protein 256

decreases expression

tolcapone results in decreased expression of TMEM256 mRNA

NCBI chr10:54,559,030...54,560,146
Ensembl chr10:54,555,360...54,560,120

G

thymosin beta 4, X-linked

decreases expression

tolcapone results in decreased expression of TMSB4X mRNA

NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667

G

TNF alpha induced protein 8

affects binding

tolcapone binds to TNFAIP8 protein

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

TNF receptor superfamily member 1A

increases expression

tolcapone results in increased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

translocase of outer mitochondrial membrane 20

affects binding

tolcapone binds to TOMM20 protein

NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198

G

translocase of outer mitochondrial membrane 40

affects binding

tolcapone binds to TOMM40 protein

NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915

G

translocase of outer mitochondrial membrane 7

affects binding

tolcapone binds to TOMM7 protein

NCBI chr 4:11,305,122...11,311,963
Ensembl chr 4:11,305,110...11,311,962

G

tumor protein p53 inducible protein 3

decreases expression

Tolcapone results in decreased expression of TP53I3 mRNA

NCBI chr 6:27,818,327...27,825,753

G

trafficking protein particle complex subunit 2L

decreases expression

tolcapone results in decreased expression of TRAPPC2L mRNA

NCBI chr19:50,662,507...50,666,193
Ensembl chr19:50,662,507...50,666,192

G

tetraspanin 6

decreases expression

tolcapone results in decreased expression of TSPAN6 mRNA

NCBI chr X:97,092,394...97,099,659
Ensembl chr X:97,092,388...97,099,309

G

tubulin, beta 6 class V

affects binding

tolcapone binds to TUBB6 protein

NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418

G

thioredoxin domain containing 17

decreases expression

tolcapone results in decreased expression of TXNDC17 mRNA

NCBI chr10:56,832,749...56,835,721

G

ubiquitin C-terminal hydrolase L3, pseudogene 1

decreases expression

tolcapone results in decreased expression of UCHL3-PS1 mRNA

NCBI chr 3:161,856,954...161,857,835

G

UDP glucuronosyltransferase family 1 member A9

decreases glucuronidation
increases glucuronidation

UGT1A9 protein mutant form results in decreased glucuronidation of tolcapone
UGT1A9 protein results in increased glucuronidation of tolcapone

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

ubiquinol cytochrome c reductase core protein 2

affects binding

tolcapone binds to UQCRC2 protein

NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

affects binding

tolcapone binds to UQCRFS1 protein

NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479

G

UV radiation resistance associated

increases expression

tolcapone results in increased expression of UVRAG mRNA

NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136

G

voltage-dependent anion channel 2

affects binding

tolcapone binds to VDAC2 protein

NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553

G

voltage-dependent anion channel 3

affects binding

tolcapone binds to VDAC3 protein

NCBI chr16:69,434,982...69,451,473
Ensembl chr16:69,435,005...69,451,471

G

visinin-like 1

affects binding

tolcapone binds to VSNL1 protein

NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479

G

WASH complex subunit 3

decreases expression

tolcapone results in decreased expression of WASHC3 mRNA

NCBI chr 7:22,621,078...22,665,550
Ensembl chr 7:22,621,078...22,690,696

G

wolframin ER transmembrane glycoprotein

affects binding

tolcapone binds to WFS1 protein

NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602

G

tyrosyl-tRNA synthetase 1

increases expression

Tolcapone results in increased expression of YARS1 mRNA

NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833

G

YEATS domain containing 4

decreases expression

tolcapone results in decreased expression of YEATS4 mRNA

NCBI chr 7:52,858,313...52,865,454
Ensembl chr 7:52,858,305...52,865,635

G

zinc and ring finger 1

increases expression

tolcapone results in increased expression of ZNRF1 mRNA

NCBI chr19:39,496,414...39,581,600
Ensembl chr19:39,496,527...39,580,969

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
role	19818
application	19630
pharmaceutical	19503
drug	19471
antidyskinesia agent	1547
L-dopa +	0
antiparkinson drug +	1179
apomorphine +	28
benzatropine +	329
biperiden +	10
bromocriptine +	41
carbidopa	19
cycrimine +	0
diphenhydramine +	21
entacapone +	26
haloperidol	519
lisuride +	5
orphenadrine +	419
pimozide	6
pramipexole	10
procyclidine +	13
profenamine +	2
ropinirole	13

paths to the root