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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:olivetolic acid
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Accession:CHEBI:66955 term browser browse the term
Definition:A member of the class of benzoic acids that is salicylic acid in which the hydrogens ortho- and para- to the carboxy group are replaced by a pentyl and a hydroxy group, respectively.
Synonyms:exact_synonym: 2,4-dihydroxy-6-pentylbenzoic acid
 related_synonym: 6-pentyl-beta-resorcylic acid;   Formula=C12H16O4;   InChI=1S/C12H16O4/c1-2-3-4-5-8-6-9(13)7-10(14)11(8)12(15)16/h6-7,13-14H,2-5H2,1H3,(H,15,16);   InChIKey=SXFKFRRXJUJGSS-UHFFFAOYSA-N;   SMILES=CCCCCc1cc(O)cc(O)c1C(O)=O;   allazetolcarboxylic acid;   olivetolcarboxylic acid
 xref: CAS:491-72-5;   MetaCyc:CPD-7165;   PMID:19454282;   PMID:22802619;   Reaxys:2807862
 cyclic_relationship: is_conjugate_acid_of CHEBI:66950


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cannabidiolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhlhe41 basic helix-loop-helix family, member e41 increases expression ISO cannabidiolic acid results in increased expression of BHLHE41 mRNA CTD PMID:25242400 NCBI chr 4:180,230,742...180,235,138
Ensembl chr 4:180,232,382...180,234,804
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO cannabidiolic acid results in decreased expression of FOS mRNA CTD PMID:27530354 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases expression ISO cannabidiolic acid results in increased expression of HTR1A mRNA CTD PMID:27530354 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO cannabidiolic acid results in decreased expression of ID1 mRNA CTD PMID:25242400 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
ISO cannabidiolic acid results in increased expression of PPARG mRNA
cannabidiolic acid results in decreased expression of PPARG protein
CTD PMID:28853159 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO cannabidiolic acid results in decreased expression of PTGS2 mRNA
cannabidiolic acid inhibits the reaction [GW 501516 results in increased expression of PTGS2 mRNA]; cannabidiolic acid promotes the reaction [GSK0660 results in decreased expression of PTGS2 mRNA]
CTD PMID:25242400 PMID:27530354 PMID:32238697 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO cannabidiolic acid results in increased activity of TRPA1 protein CTD PMID:31096838 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 decreases expression ISO cannabidiolic acid results in decreased expression of TRPM8 mRNA CTD PMID:27530354 NCBI chr 9:95,393,370...95,484,528
Ensembl chr 9:95,398,237...95,482,890
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity
multiple interactions
ISO cannabidiolic acid results in increased activity of TRPV1 protein
[cannabidiolic acid results in increased activity of TRPV1 protein] which results in increased uptake of Calcium
CTD PMID:31096838 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 multiple interactions
increases expression
ISO [cannabidiolic acid results in increased activity of TRPV2 protein] which results in increased uptake of Calcium
cannabidiolic acid results in increased expression of TRPV2 mRNA
CTD PMID:27530354 PMID:31096838 NCBI chr10:48,903,540...48,925,036
Ensembl chr10:48,903,540...48,925,030
JBrowse link
cannabigerolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
ISO cannabigerolic acid results in increased expression of PPARG mRNA
cannabigerolic acid results in decreased expression of PPARG protein
CTD PMID:28853159 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases activity
ISO [cannabigerolic acid results in increased activity of TRPV1 protein] which results in increased uptake of Calcium CTD PMID:31096838 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      biological role 19833
        biochemical role 19370
          metabolite 19350
            olivetolic acid 10
              cannabidiolic acid 10
              cannabigerolic acid 2
              cannabinerolic acid 0
              cytonic acid A 0
              cytonic acid B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      carboxylic acid 18153
                                        aromatic carboxylic acid 10918
                                          benzoic acids 10887
                                            olivetolic acid 10
                                              cannabidiolic acid 10
                                              cannabigerolic acid 2
                                              cannabinerolic acid 0
                                              cytonic acid A 0
                                              cytonic acid B 0
paths to the root