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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:olivetolic acid
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Accession:CHEBI:66955 term browser browse the term
Definition:A member of the class of benzoic acids that is salicylic acid in which the hydrogens ortho- and para- to the carboxy group are replaced by a pentyl and a hydroxy group, respectively.
Synonyms:exact_synonym: 2,4-dihydroxy-6-pentylbenzoic acid
 related_synonym: 6-pentyl-beta-resorcylic acid;   Formula=C12H16O4;   InChI=1S/C12H16O4/c1-2-3-4-5-8-6-9(13)7-10(14)11(8)12(15)16/h6-7,13-14H,2-5H2,1H3,(H,15,16);   InChIKey=SXFKFRRXJUJGSS-UHFFFAOYSA-N;   SMILES=CCCCCc1cc(O)cc(O)c1C(O)=O;   allazetolcarboxylic acid;   olivetolcarboxylic acid
 xref: CAS:491-72-5;   MetaCyc:CPD-7165;   PMID:19454282;   PMID:22802619;   Reaxys:2807862
 cyclic_relationship: is_conjugate_acid_of CHEBI:66950


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cannabidiolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHLHE41 basic helix-loop-helix family member e41 increases expression EXP cannabidiolic acid results in increased expression of BHLHE41 mRNA CTD PMID:25242400 NCBI chr12:26,120,030...26,125,037
Ensembl chr12:26,120,030...26,125,037
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP cannabidiolic acid results in decreased expression of FOS mRNA CTD PMID:27530354 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A increases expression EXP cannabidiolic acid results in increased expression of HTR1A mRNA CTD PMID:27530354 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,960,356...63,962,507
Ensembl chr 5:63,960,356...63,962,507
JBrowse link
G ID1 inhibitor of DNA binding 1, HLH protein decreases expression EXP cannabidiolic acid results in decreased expression of ID1 mRNA CTD PMID:25242400 NCBI chr20:31,605,289...31,606,510
Ensembl chr20:31,605,283...31,606,515
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression
increases expression
EXP cannabidiolic acid results in decreased expression of PPARG protein
cannabidiolic acid results in increased expression of PPARG mRNA
CTD PMID:28853159 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP cannabidiolic acid results in decreased expression of PTGS2 mRNA
cannabidiolic acid inhibits the reaction [GW 501516 results in increased expression of PTGS2 mRNA]; cannabidiolic acid promotes the reaction [GSK0660 results in decreased expression of PTGS2 mRNA]
CTD PMID:25242400 PMID:27530354 PMID:32238697 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 increases activity EXP cannabidiolic acid results in increased activity of TRPA1 protein CTD PMID:31096838 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TRPM8 transient receptor potential cation channel subfamily M member 8 decreases expression EXP cannabidiolic acid results in decreased expression of TRPM8 mRNA CTD PMID:27530354 NCBI chr 2:233,917,342...234,019,522
Ensembl chr 2:233,917,373...234,019,522
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 increases activity
multiple interactions
EXP cannabidiolic acid results in increased activity of TRPV1 protein
[cannabidiolic acid results in increased activity of TRPV1 protein] which results in increased uptake of Calcium
CTD PMID:31096838 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G TRPV2 transient receptor potential cation channel subfamily V member 2 multiple interactions
increases expression
EXP [cannabidiolic acid results in increased activity of TRPV2 protein] which results in increased uptake of Calcium
cannabidiolic acid results in increased expression of TRPV2 mRNA
CTD PMID:27530354 PMID:31096838 NCBI chr17:16,415,543...16,437,003
Ensembl chr17:16,415,571...16,437,003
JBrowse link
cannabigerolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARG peroxisome proliferator activated receptor gamma increases expression
decreases expression
EXP cannabigerolic acid results in increased expression of PPARG mRNA
cannabigerolic acid results in decreased expression of PPARG protein
CTD PMID:28853159 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions
increases activity
EXP [cannabigerolic acid results in increased activity of TRPV1 protein] which results in increased uptake of Calcium CTD PMID:31096838 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24381
    role 24291
      biological role 24258
        biochemical role 23647
          metabolite 23566
            olivetolic acid 10
              cannabidiolic acid 10
              cannabigerolic acid 2
              cannabinerolic acid 0
              cytonic acid A 0
              cytonic acid B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24381
    subatomic particle 24338
      composite particle 24338
        hadron 24338
          baryon 24338
            nucleon 24338
              atomic nucleus 24338
                atom 24338
                  main group element atom 24185
                    p-block element atom 24185
                      carbon group element atom 23965
                        carbon atom 23925
                          organic molecular entity 23925
                            organic group 22218
                              organic divalent group 22192
                                organodiyl group 22192
                                  carbonyl group 22175
                                    carbonyl compound 22175
                                      carboxylic acid 21201
                                        aromatic carboxylic acid 11619
                                          benzoic acids 11588
                                            olivetolic acid 10
                                              cannabidiolic acid 10
                                              cannabigerolic acid 2
                                              cannabinerolic acid 0
                                              cytonic acid A 0
                                              cytonic acid B 0
paths to the root