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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:olivetolic acid
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Accession:CHEBI:66955 term browser browse the term
Definition:A member of the class of benzoic acids that is salicylic acid in which the hydrogens ortho- and para- to the carboxy group are replaced by a pentyl and a hydroxy group, respectively.
Synonyms:exact_synonym: 2,4-dihydroxy-6-pentylbenzoic acid
 related_synonym: 6-pentyl-beta-resorcylic acid;   Formula=C12H16O4;   InChI=1S/C12H16O4/c1-2-3-4-5-8-6-9(13)7-10(14)11(8)12(15)16/h6-7,13-14H,2-5H2,1H3,(H,15,16);   InChIKey=SXFKFRRXJUJGSS-UHFFFAOYSA-N;   SMILES=CCCCCc1cc(O)cc(O)c1C(O)=O;   allazetolcarboxylic acid;   olivetolcarboxylic acid
 xref: CAS:491-72-5;   MetaCyc:CPD-7165;   PMID:19454282;   PMID:22802619;   Reaxys:2807862
 cyclic_relationship: is_conjugate_acid_of CHEBI:66950



show annotations for term's descendants           Sort by:
cannabidiolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases expression ISO cannabidiolic acid results in increased expression of ACOX1 mRNA CTD PMID:30611848 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 increases expression ISO cannabidiolic acid results in increased expression of BHLHE41 mRNA CTD PMID:25242400 NCBI chr 4:178,833,085...178,838,685
Ensembl chr 4:178,834,271...178,838,468
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression
ISO cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]
cannabidiolic acid results in increased expression of CEBPA mRNA
CTD PMID:30611848 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO cannabidiolic acid results in increased expression of CPT1A mRNA CTD PMID:30611848 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
ISO cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]
cannabidiolic acid results in increased expression of FABP4 mRNA
CTD PMID:30611848 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO cannabidiolic acid results in decreased expression of FOS mRNA CTD PMID:27530354 PMID:30496661 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases expression ISO cannabidiolic acid results in increased expression of HTR1A mRNA CTD PMID:27530354 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO cannabidiolic acid results in decreased expression of ID1 mRNA CTD PMID:25242400 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO cannabidiolic acid results in decreased expression of IGF1 protein CTD PMID:33010341 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Ins2 insulin 2 multiple interactions ISO cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA] CTD PMID:30611848 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
ISO cannabidiolic acid binds to and results in increased activity of PPARA protein
cannabidiolic acid results in increased expression of PPARA mRNA
CTD PMID:30611848 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
decreases expression
ISO cannabidiolic acid results in increased expression of PPARG mRNA
cannabidiolic acid binds to and results in increased activity of PPARG protein; cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]
cannabidiolic acid results in decreased expression of PPARG protein
CTD PMID:28853159 PMID:30611848 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO cannabidiolic acid results in decreased expression of PTGS2 mRNA
cannabidiolic acid inhibits the reaction [GW 501516 results in increased expression of PTGS2 mRNA]; cannabidiolic acid promotes the reaction [GSK0660 results in decreased expression of PTGS2 mRNA]
CTD PMID:25242400 PMID:27530354 PMID:30496661 PMID:32238697 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO cannabidiolic acid results in increased activity of TRPA1 protein CTD PMID:31096838 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 decreases expression ISO cannabidiolic acid results in decreased expression of TRPM8 mRNA CTD PMID:27530354 NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity
multiple interactions
ISO cannabidiolic acid results in increased activity of TRPV1 protein
[cannabidiolic acid results in increased activity of TRPV1 protein] which results in increased uptake of Calcium
CTD PMID:31096838 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 multiple interactions
increases expression
ISO [cannabidiolic acid results in increased activity of TRPV2 protein] which results in increased uptake of Calcium
cannabidiolic acid results in increased expression of TRPV2 mRNA
CTD PMID:27530354 PMID:31096838 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
JBrowse link
cannabigerolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases expression ISO cannabigerolic acid results in increased expression of ACOX1 mRNA CTD PMID:30611848 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO cannabigerolic acid results in increased expression of CPT1A mRNA CTD PMID:30611848 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
ISO cannabigerolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]
cannabigerolic acid results in increased expression of FABP4 mRNA
CTD PMID:30611848 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Ins2 insulin 2 multiple interactions ISO cannabigerolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; cannabigerolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA] CTD PMID:30611848 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions
ISO cannabigerolic acid results in increased expression of PPARA mRNA
cannabigerolic acid binds to and results in increased activity of PPARA protein
CTD PMID:30611848 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
multiple interactions
ISO cannabigerolic acid results in increased expression of PPARG mRNA
cannabigerolic acid results in decreased expression of PPARG protein
cannabigerolic acid binds to and results in increased activity of PPARG protein; cannabigerolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]
CTD PMID:28853159 PMID:30611848 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases activity
ISO [cannabigerolic acid results in increased activity of TRPV1 protein] which results in increased uptake of Calcium CTD PMID:31096838 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 affects activity EXP cannabigerolic acid affects the activity of TRPV3 protein CTD PMID:21726418 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        biochemical role 19429
          metabolite 19416
            olivetolic acid 18
              cannabidiolic acid 17
              cannabigerolic acid 8
              cannabinerolic acid 0
              cytonic acid A 0
              cytonic acid B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        aromatic carboxylic acid 11801
                                          benzoic acids 11775
                                            olivetolic acid 18
                                              cannabidiolic acid 17
                                              cannabigerolic acid 8
                                              cannabinerolic acid 0
                                              cytonic acid A 0
                                              cytonic acid B 0
paths to the root