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G |
Gli1 |
GLI family zinc finger 1 |
decreases expression |
ISO |
sonidegib results in decreased expression of GLI1 mRNA |
CTD |
PMID:24973920 |
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NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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G |
Gli2 |
GLI family zinc finger 2 |
decreases expression multiple interactions decreases response to substance |
ISO |
sonidegib results in decreased expression of GLI2 mRNA sonidegib inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA] GLI2 protein results in decreased susceptibility to sonidegib |
CTD |
PMID:24973920 |
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NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
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G |
Mtor |
mechanistic target of rapamycin kinase |
increases phosphorylation |
EXP |
sonidegib results in increased phosphorylation of MTOR protein |
CTD |
PMID:31568847 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Mycn |
MYCN proto-oncogene, bHLH transcription factor |
decreases response to substance |
ISO |
MYCN protein results in decreased susceptibility to sonidegib |
CTD |
PMID:24973920 |
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NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
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G |
Smo |
smoothened, frizzled class receptor |
decreases response to substance |
ISO |
SMO protein mutant form results in decreased susceptibility to sonidegib |
CTD |
PMID:24973920 |
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NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
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G |
Sufu |
SUFU negative regulator of hedgehog signaling |
multiple interactions decreases response to substance |
ISO |
sonidegib inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA] SUFU gene mutant form results in decreased susceptibility to sonidegib |
CTD |
PMID:24973920 |
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NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577
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G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
HhAntag691 inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; HhAntag691 inhibits the reaction [AGT protein results in increased expression of SHH protein] |
CTD |
PMID:31181250 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein] |
CTD |
PMID:22087285 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
HhAntag691 inhibits the reaction [nickel monoxide results in decreased expression of BECN1 protein] |
CTD |
PMID:34608745 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
HhAntag691 results in increased cleavage of CASP3 protein |
CTD |
PMID:22087285 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
HhAntag691 results in decreased expression of CCND1 mRNA |
CTD |
PMID:24973920 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd2 |
cyclin D2 |
decreases expression |
ISO |
HhAntag691 results in decreased expression of CCND2 mRNA |
CTD |
PMID:24973920 |
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NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression |
ISO |
HhAntag691 results in decreased expression of CDK6 mRNA |
CTD |
PMID:24973920 |
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NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Fas |
Fas cell surface death receptor |
increases expression multiple interactions |
ISO |
HhAntag691 results in increased expression of FAS protein [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein] |
CTD |
PMID:22087285 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Gli1 |
GLI family zinc finger 1 |
multiple interactions decreases expression |
ISO |
[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10B protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the susceptibility to HhAntag691; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] vismodegib decreases Gli1 protein expression in pituitary adenoma cells HhAntag691 results in decreased expression of GLI1 mRNA |
CTD RGD |
PMID:22087285 PMID:24973920 PMID:27585885 PMID:31181250 PMID:31642701 PMID:31519191 More...
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RGD:150573695 |
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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G |
Gli2 |
GLI family zinc finger 2 |
multiple interactions increases response to substance decreases expression decreases response to substance |
ISO |
[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10B protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the susceptibility to HhAntag691; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI2 protein] GLI2 gene mutant form results in increased susceptibility to HhAntag691 HhAntag691 results in decreased expression of GLI2 mRNA GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA] GLI2 protein results in decreased susceptibility to HhAntag691 |
CTD |
PMID:22087285 PMID:24973920 PMID:27585885 PMID:31181250 |
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NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
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G |
Gli3 |
GLI family zinc finger 3 |
multiple interactions |
ISO |
HhAntag691 inhibits the reaction [AGT protein results in decreased expression of GLI3 protein] |
CTD |
PMID:31181250 |
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NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
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G |
Hhip |
Hedgehog-interacting protein |
decreases expression |
ISO |
HhAntag691 results in decreased expression of HHIP mRNA |
CTD |
PMID:24973920 |
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NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
HhAntag691 inhibits the reaction [nickel monoxide results in decreased lipidation of and results in decreased cleavage of MAP1LC3B protein] |
CTD |
PMID:34608745 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G |
Mycn |
MYCN proto-oncogene, bHLH transcription factor |
decreases response to substance |
ISO |
MYCN protein results in decreased susceptibility to HhAntag691 |
CTD |
PMID:24973920 |
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NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
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G |
Pax6 |
paired box 6 |
increases expression |
ISO |
HhAntag691 results in increased expression of PAX6 mRNA |
CTD |
PMID:27585885 |
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NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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G |
Pdgfra |
platelet derived growth factor receptor alpha |
multiple interactions decreases expression |
ISO |
[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein] |
CTD |
PMID:22087285 |
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NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
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G |
Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
increases expression |
ISO |
vismodegib increases protein kinase A protein expression in pituitary adenoma cells |
RGD |
PMID:31519191 |
RGD:150573695 |
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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G |
Ptch1 |
patched 1 |
decreases expression multiple interactions |
ISO |
HhAntag691 results in decreased expression of PTCH1 mRNA GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA] |
CTD |
PMID:22087285 PMID:24973920 PMID:27585885 |
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NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
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G |
Ptch2 |
patched 2 |
decreases expression |
ISO |
HhAntag691 results in decreased expression of PTCH2 mRNA |
CTD |
PMID:22087285 |
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NCBI chr 5:130,571,956...130,592,506
Ensembl chr 5:130,572,312...130,592,405
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G |
Shh |
sonic hedgehog signaling molecule |
decreases expression multiple interactions |
ISO |
HhAntag691 results in decreased expression of SHH mRNA GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA] HhAntag691 inhibits the reaction [AGT protein results in increased expression of SHH protein]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] |
CTD |
PMID:27585885 PMID:31181250 PMID:31642701 |
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NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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G |
Smo |
smoothened, frizzled class receptor |
decreases expression decreases response to substance |
ISO |
HhAntag691 results in decreased expression of SMO mRNA SMO protein mutant form results in decreased susceptibility to HhAntag691 |
CTD |
PMID:22087285 PMID:24973920 |
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NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
HhAntag691 inhibits the reaction [nickel monoxide results in increased expression of SQSTM1 protein] |
CTD |
PMID:34608745 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Sufu |
SUFU negative regulator of hedgehog signaling |
decreases response to substance increases expression multiple interactions |
ISO |
SUFU gene mutant form results in decreased susceptibility to HhAntag691 vismodegib increases SUFU protein expression in pituitary adenoma cells HhAntag691 inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA] |
CTD RGD |
PMID:24973920 PMID:31519191 |
RGD:150573695 |
NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577
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G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
increases expression multiple interactions |
ISO |
HhAntag691 results in increased expression of TNFRSF10A protein [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein] |
CTD |
PMID:22087285 |
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NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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