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ONTOLOGY REPORT - ANNOTATIONS


Term:vismodegib
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Accession:CHEBI:66903 term browser browse the term
Definition:A benzamide obtained by formal condensation between the carboxy group of 2-chloro-4-(methylsulfonyl)benzoic acid and the anilino group of 4-chloro-3-(pyridin-2-yl)aniline. Used for the treatment metastatic basal cell carcinoma.
Synonyms:exact_synonym: 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide
 related_synonym: Erivedge;   Formula=C19H14Cl2N2O3S;   InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24);   InChIKey=BPQMGSKTAYIVFO-UHFFFAOYSA-N;   SMILES=CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(c2)-c2ccccn2)c(Cl)c1;   vismodegibum
 alt_id: MESH:C538724
 xref: CAS:879085-55-9 "ChemIDplus";   CAS:879085-55-9 "KEGG DRUG";   Drug_Central:4227 "DrugCentral"
 xref_mesh: MESH:C538724
 xref: PMID:21602311 "Europe PMC";   PMID:21610148 "Europe PMC";   PMID:21753154 "Europe PMC";   PMID:22458643 "Europe PMC";   PMID:22489352 "Europe PMC";   PMID:22618984 "Europe PMC";   PMID:22653209 "Europe PMC";   PMID:22670903 "Europe PMC";   PMID:22670904 "Europe PMC";   PMID:22679179 "Europe PMC";   PMID:22718857 "Europe PMC";   PMID:22777303 "Europe PMC";   PMID:22788238 "Europe PMC";   PMID:22805146 "Europe PMC";   PMID:22844657 "Europe PMC";   Reaxys:12532124 "Reaxys";   Wikipedia:Vismodegib


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vismodegib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccnd2 cyclin D2 JBrowse link 4 159,674,885 159,697,207 RGD:6480464
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:6480464
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:6480464
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:6480464
G Hhip Hedgehog-interacting protein JBrowse link 19 31,525,134 31,614,487 RGD:6480464
G Mycn MYCN proto-oncogene, bHLH transcription factor JBrowse link 6 38,222,554 38,228,419 RGD:6480464
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:6480464
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:6480464
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:6480464
G Ptch2 patched 2 JBrowse link 5 135,962,252 135,983,816 RGD:6480464
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:6480464
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:6480464
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:6480464
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        aetiopathogenetic role 18761
          teratogenic agent 15863
            vismodegib 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        carboacyl group 16944
                                          univalent carboacyl group 16944
                                            carbamoyl group 16623
                                              carboxamide 16623
                                                monocarboxylic acid amide 13187
                                                  arenecarboxamide 6405
                                                    benzamides 6405
                                                      vismodegib 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.