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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vismodegib
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Accession:CHEBI:66903 term browser browse the term
Definition:A benzamide obtained by formal condensation between the carboxy group of 2-chloro-4-(methylsulfonyl)benzoic acid and the anilino group of 4-chloro-3-(pyridin-2-yl)aniline. Used for the treatment metastatic basal cell carcinoma.
Synonyms:exact_synonym: 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide
 related_synonym: Erivedge;   Formula=C19H14Cl2N2O3S;   InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24);   InChIKey=BPQMGSKTAYIVFO-UHFFFAOYSA-N;   SMILES=CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(c2)-c2ccccn2)c(Cl)c1;   vismodegibum
 alt_id: MESH:C538724
 xref: CAS:879085-55-9;   Drug_Central:4227
 xref_mesh: MESH:C538724
 xref: PMID:21602311;   PMID:21610148;   PMID:21753154;   PMID:22458643;   PMID:22489352;   PMID:22618984;   PMID:22653209;   PMID:22670903;   PMID:22670904;   PMID:22679179;   PMID:22718857;   PMID:22777303;   PMID:22788238;   PMID:22805146;   PMID:22844657;   Reaxys:12532124;   Wikipedia:Vismodegib


show annotations for term's descendants           Sort by:
vismodegib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions ISO HhAntag691 inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; HhAntag691 inhibits the reaction [AGT protein results in increased expression of SHH protein] CTD PMID:31181250 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		ISO [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein] CTD PMID:22087285 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO HhAntag691 inhibits the reaction [nickel monoxide results in decreased expression of BECN1 protein] CTD PMID:34608745 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO HhAntag691 results in increased cleavage of CASP3 protein CTD PMID:22087285 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO HhAntag691 results in decreased expression of CCND1 mRNA CTD PMID:24973920 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO HhAntag691 results in decreased expression of CCND2 mRNA CTD PMID:24973920 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO HhAntag691 results in decreased expression of CDK6 mRNA CTD PMID:24973920 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Efcab7 EF-hand calcium binding domain 7 affects response to substance ISO EFCAB7 protein affects the susceptibility to HhAntag691 CTD PMID:39366525 NCBI chr 5:114,525,403...114,576,130
Ensembl chr 5:114,525,167...114,576,129 		JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions 		ISO HhAntag691 results in increased expression of FAS protein
[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein] 		CTD PMID:22087285 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions
decreases expression
decreases expression 		ISO [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10B protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the susceptibility to HhAntag691; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]
HhAntag691 results in decreased expression of GLI1 mRNA
vismodegib decreases Gli1 protein expression in pituitary adenoma cells 		CTD
RGD		 PMID:22087285 PMID:24973920 PMID:27585885 PMID:31181250 PMID:31642701 More... RGD:150573695 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions
decreases response to substance
decreases expression
increases response to substance 		ISO [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10B protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the susceptibility to HhAntag691; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI2 protein]
GLI2 protein results in decreased susceptibility to HhAntag691
GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]
HhAntag691 results in decreased expression of GLI2 mRNA
GLI2 gene mutant form results in increased susceptibility to HhAntag691 		CTD PMID:22087285 PMID:24973920 PMID:27585885 PMID:31181250 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gli3 GLI family zinc finger 3 multiple interactions ISO HhAntag691 inhibits the reaction [AGT protein results in decreased expression of GLI3 protein] CTD PMID:31181250 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Hhip Hedgehog-interacting protein decreases expression ISO HhAntag691 results in decreased expression of HHIP mRNA CTD PMID:24973920 NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO HhAntag691 inhibits the reaction [nickel monoxide results in decreased lipidation of and results in decreased cleavage of MAP1LC3B protein] CTD PMID:34608745 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor decreases response to substance ISO MYCN protein results in decreased susceptibility to HhAntag691 CTD PMID:24973920 NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590 		JBrowse link
G Nkx2-1 NK2 homeobox 1 decreases expression ISO HhAntag691 results in decreased expression of NKX2.1 mRNA CTD PMID:27585885 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791 		JBrowse link
G Pax6 paired box 6 increases expression ISO HhAntag691 results in increased expression of PAX6 mRNA CTD PMID:27585885 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha multiple interactions
decreases expression 		ISO [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein] CTD PMID:22087285 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression ISO vismodegib increases protein kinase A protein expression in pituitary adenoma cells RGD PMID:31519191 RGD:150573695 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Ptch1 patched 1 decreases expression
multiple interactions 		ISO HhAntag691 results in decreased expression of PTCH1 mRNA
GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA] 		CTD PMID:22087285 PMID:24973920 PMID:27585885 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Ptch2 patched 2 decreases expression ISO HhAntag691 results in decreased expression of PTCH2 mRNA CTD PMID:22087285 NCBI chr 5:130,571,956...130,592,506
Ensembl chr 5:130,572,312...130,592,405 		JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression
multiple interactions 		ISO HhAntag691 results in decreased expression of SHH mRNA
GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]
HhAntag691 inhibits the reaction [AGT protein results in increased expression of SHH protein]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] 		CTD PMID:27585885 PMID:31181250 PMID:31642701 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Smo smoothened, frizzled class receptor decreases expression
decreases response to substance 		ISO HhAntag691 results in decreased expression of SMO mRNA
SMO protein mutant form results in decreased susceptibility to HhAntag691 		CTD PMID:22087285 PMID:24973920 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO HhAntag691 inhibits the reaction [nickel monoxide results in increased expression of SQSTM1 protein] CTD PMID:34608745 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling decreases response to substance
multiple interactions
increases expression 		ISO SUFU gene mutant form results in decreased susceptibility to HhAntag691
HhAntag691 inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]
vismodegib increases SUFU protein expression in pituitary adenoma cells 		CTD
RGD		 PMID:24973920 PMID:31519191 RGD:150573695 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression
multiple interactions 		ISO HhAntag691 results in increased expression of TNFRSF10A protein
[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein] 		CTD PMID:22087285 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      biological role 20803
        aetiopathogenetic role 19841
          teratogenic agent 16245
            vismodegib 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    p-block element atom 20766
                      carbon group element atom 20699
                        carbon atom 20693
                          organic molecular entity 20693
                            heteroorganic entity 20202
                              organochalcogen compound 19890
                                organooxygen compound 19792
                                  carbon oxoacid 19137
                                    carboxylic acid 19134
                                      carboacyl group 18064
                                        univalent carboacyl group 18064
                                          carbamoyl group 17899
                                            carboxamide 17899
                                              monocarboxylic acid amide 15935
                                                arenecarboxamide 8277
                                                  benzamides 8277
                                                    vismodegib 26
paths to the root