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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:CFTR potentiator
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Accession:CHEBI:66902 term browser browse the term
Definition:A membrane transport modulator that restores the chloride ion transport ability of defective cystic fibrosis transmembrane conductance regulator (CFTR) genes.
Synonyms:related_synonym: CFTR potentiators;   cystic fibrosis transmembrane conductance regulator potentiator;   cystic fibrosis transmembrane conductance regulator potentiators
 xref: Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator


show annotations for term's descendants           Sort by:
fucoxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl increases expression EXP fucoxanthin results in increased expression of ACOX1 mRNA CTD PMID:20519145 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Acta1 actin alpha 1, skeletal muscle multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of ACTA1 mRNA] CTD PMID:33448797 NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490 		JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased methylation of ADCY7 gene]; fucoxanthin inhibits the reaction [Glucose results in increased expression of ADCY7 mRNA] CTD PMID:33448797 NCBI chr 8:88,998,818...89,056,593
Ensembl chr 8:88,999,031...89,056,590 		JBrowse link
G Ak8 adenylate kinase 8 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of AK8 mRNA] CTD PMID:33448797 NCBI chr 2:28,588,287...28,703,177
Ensembl chr 2:28,590,176...28,703,177 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases expression		 EXP
ISO		 fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of AKT1 protein]
fucoxanthin results in decreased expression of AKT1 mRNA		 CTD PMID:26418808 PMID:35266250 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of ALCAM mRNA] CTD PMID:33448797 NCBI chr16:52,069,359...52,273,444
Ensembl chr16:52,069,359...52,274,437 		JBrowse link
G Ankrd61 ankyrin repeat domain 61 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of ANKRD61 mRNA] CTD PMID:33448797 NCBI chr 5:143,827,455...143,831,885
Ensembl chr 5:143,827,559...143,834,503 		JBrowse link
G Arhgdib Rho, GDP dissociation inhibitor (GDI) beta multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of ARHGDIB mRNA] CTD PMID:33448797 NCBI chr 6:136,900,653...136,918,895
Ensembl chr 6:136,900,653...136,918,897 		JBrowse link
G Armcx6 armadillo repeat containing, X-linked 6 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of ARMCX6 mRNA] CTD PMID:33448797 NCBI chr  X:133,649,204...133,657,236
Ensembl chr  X:133,649,210...133,652,166 		JBrowse link
G Atg10 autophagy related 10 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of ATG10 mRNA] CTD PMID:33448797 NCBI chr13:91,083,467...91,372,189
Ensembl chr13:91,083,475...91,372,087 		JBrowse link
G Atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of ATP2A1 mRNA] CTD PMID:33448797 NCBI chr 7:126,045,032...126,062,245
Ensembl chr 7:126,045,030...126,062,280 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of BAMBI mRNA] CTD PMID:33448797 NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404 		JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of BCHE mRNA] CTD PMID:33448797 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO fucoxanthin results in decreased expression of BCL2 mRNA CTD PMID:35266250 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein] CTD PMID:20594983 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bmp8b bone morphogenetic protein 8b multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of BMP8B mRNA] CTD PMID:33448797 NCBI chr 4:122,998,101...123,019,887
Ensembl chr 4:122,998,958...123,025,892 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO fucoxanthin results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP3 protein]		 CTD PMID:20594983 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP7 protein] CTD PMID:20594983 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casz1 castor zinc finger 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of CASZ1 mRNA] CTD PMID:33448797 NCBI chr 4:148,888,823...149,039,350
Ensembl chr 4:148,888,886...149,039,346 		JBrowse link
G Cat catalase multiple interactions EXP fucoxanthin inhibits the reaction [Carrageenan results in decreased activity of CAT protein] CTD PMID:26418808 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccdc116 coiled-coil domain containing 116 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of CCDC116 mRNA] CTD PMID:33448797 NCBI chr16:16,956,928...16,965,459
Ensembl chr16:16,956,928...16,965,093 		JBrowse link
G Ccr10 chemokine (C-C motif) receptor 10 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of CCR10 mRNA] CTD PMID:33448797 NCBI chr11:101,063,824...101,066,269
Ensembl chr11:101,063,823...101,066,269 		JBrowse link
G Cd1d1 CD1d1 antigen multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of CD1D1 mRNA] CTD PMID:33448797 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of CELSR1 mRNA] CTD PMID:33448797 NCBI chr15:85,782,959...85,918,424
Ensembl chr15:85,783,130...85,918,404 		JBrowse link
G Cemip cell migration inducing protein, hyaluronan binding multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of CEMIP mRNA] CTD PMID:33448797 NCBI chr 7:83,582,065...83,735,893
Ensembl chr 7:83,582,065...83,735,710 		JBrowse link
G Cfp complement factor properdin multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of CFP mRNA] CTD PMID:33448797 NCBI chr  X:20,791,693...20,797,794
Ensembl chr  X:20,791,693...20,797,794 		JBrowse link
G Cnn1 calponin 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of CNN1 mRNA] CTD PMID:33448797 NCBI chr 9:22,010,501...22,020,517
Ensembl chr 9:22,010,512...22,020,926 		JBrowse link
G Col7a1 collagen, type VII, alpha 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of COL7A1 mRNA] CTD PMID:33448797 NCBI chr 9:108,782,654...108,813,943
Ensembl chr 9:108,782,654...108,813,943 		JBrowse link
G Cpq carboxypeptidase Q multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of CPQ mRNA] CTD PMID:33448797 NCBI chr15:33,083,275...33,594,698
Ensembl chr15:33,083,275...33,594,698 		JBrowse link
G Crlf1 cytokine receptor-like factor 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of CRLF1 mRNA] CTD PMID:33448797 NCBI chr 8:70,945,798...70,956,728
Ensembl chr 8:70,945,808...70,956,731 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of CYP2E1 mRNA] CTD PMID:33448797 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dbil5 diazepam binding inhibitor-like 5 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of DBIL5 mRNA] CTD PMID:33448797 NCBI chr11:76,108,439...76,109,491
Ensembl chr11:76,108,434...76,109,492 		JBrowse link
G Disp2 dispatched RND tramsporter family member 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of DISP2 mRNA] CTD PMID:33448797 NCBI chr 2:118,610,183...118,625,656
Ensembl chr 2:118,610,200...118,641,774 		JBrowse link
G Dmtn dematin actin binding protein multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of DMTN mRNA] CTD PMID:33448797 NCBI chr14:70,839,624...70,873,488
Ensembl chr14:70,838,703...70,873,488 		JBrowse link
G Drd3 dopamine receptor D3 increases activity ISO fucoxanthin results in increased activity of DRD3 protein CTD PMID:31323226 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Drd4 dopamine receptor D4 increases activity ISO fucoxanthin results in increased activity of DRD4 protein CTD PMID:31323226 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377 		JBrowse link
G Dusp13 dual specificity phosphatase 13 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of DUSP13B mRNA] CTD PMID:33448797 NCBI chr14:21,783,463...21,792,947
Ensembl chr14:21,783,462...21,801,249 		JBrowse link
G Elapor1 endosome-lysosome associated apoptosis and autophagy regulator 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of ELAPOR1 mRNA] CTD PMID:33448797 NCBI chr 3:108,362,995...108,444,064
Ensembl chr 3:108,363,010...108,443,852 		JBrowse link
G Esrp1 epithelial splicing regulatory protein 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of ESRP1 mRNA] CTD PMID:33448797 NCBI chr 4:11,331,933...11,386,783
Ensembl chr 4:11,331,933...11,386,783 		JBrowse link
G Fam78b family with sequence similarity 78, member B multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of FAM78B mRNA] CTD PMID:33448797 NCBI chr 1:166,827,456...166,918,871
Ensembl chr 1:166,828,986...166,918,871 		JBrowse link
G Fam83c family with sequence similarity 83, member C multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of FAM83C mRNA] CTD PMID:33448797 NCBI chr 2:155,671,103...155,676,772
Ensembl chr 2:155,669,468...155,676,774 		JBrowse link
G Fam98c family with sequence similarity 98, member C multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of FAM98C mRNA] CTD PMID:33448797 NCBI chr 7:28,851,935...28,855,653
Ensembl chr 7:28,851,935...28,855,659 		JBrowse link
G Fbp2 fructose bisphosphatase 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of FBP2 mRNA] CTD PMID:33448797 NCBI chr13:62,984,698...63,006,214
Ensembl chr13:62,984,691...63,006,236 		JBrowse link
G Fcho1 FCH domain only 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of FCHO1 mRNA] CTD PMID:33448797 NCBI chr 8:72,161,031...72,181,980
Ensembl chr 8:72,161,031...72,178,360 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of FGF1 mRNA] CTD PMID:33448797 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525 		JBrowse link
G Fgl2 fibrinogen-like protein 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of FGL2 mRNA] CTD PMID:33448797 NCBI chr 5:21,577,671...21,583,384
Ensembl chr 5:21,577,640...21,583,372 		JBrowse link
G Flg filaggrin decreases expression EXP fucoxanthin results in decreased expression of FLG mRNA CTD PMID:27590588 NCBI chr 3:93,180,853...93,200,996
Ensembl chr 3:93,180,830...93,200,993 		JBrowse link
G Fv1 Friend virus susceptibility 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of FV1 mRNA] CTD PMID:33448797 NCBI chr 4:147,953,436...147,954,815
Ensembl chr 4:147,953,436...147,954,815 		JBrowse link
G G6pd2 glucose-6-phosphate dehydrogenase 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of G6PD2 mRNA] CTD PMID:33448797 NCBI chr 5:61,966,186...61,967,820
Ensembl chr 5:61,966,159...61,968,506 		JBrowse link
G Gask1b golgi associated kinase 1B multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of GASK1B mRNA] CTD PMID:33448797 NCBI chr 3:79,791,795...79,853,585
Ensembl chr 3:79,791,840...79,853,587 		JBrowse link
G Gbp8 guanylate-binding protein 8 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of GBP8 mRNA] CTD PMID:33448797 NCBI chr 5:105,160,379...105,201,475
Ensembl chr 5:105,162,016...105,287,406 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO fucoxanthin results in increased expression of GJA1 mRNA; fucoxanthin results in increased expression of GJA1 protein CTD PMID:19737546 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gjb1 gap junction protein, beta 1 increases expression ISO fucoxanthin results in increased expression of GJB1 mRNA; fucoxanthin results in increased expression of GJB1 protein CTD PMID:19737546 NCBI chr  X:100,419,982...100,429,235
Ensembl chr  X:100,419,984...100,429,235 		JBrowse link
G Gng2 guanine nucleotide binding protein (G protein), gamma 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of GNG2 mRNA] CTD PMID:33448797 NCBI chr14:19,922,626...20,027,893
Ensembl chr14:19,922,627...20,027,695 		JBrowse link
G Gpm6b glycoprotein m6b multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of GPM6B mRNA] CTD PMID:33448797 NCBI chr  X:165,021,775...165,172,029
Ensembl chr  X:165,021,907...165,171,984 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of GRIN1 mRNA] CTD PMID:33448797 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Gulo gulonolactone (L-) oxidase multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of GULO mRNA] CTD PMID:33448797 NCBI chr14:66,224,235...66,246,703
Ensembl chr14:66,224,235...66,246,656 		JBrowse link
G Gypc glycophorin C multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of GYPC mRNA] CTD PMID:33448797 NCBI chr18:32,661,373...32,693,087
Ensembl chr18:32,661,375...32,693,087 		JBrowse link
G Hhat hedgehog acyltransferase multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of HHAT mRNA] CTD PMID:33448797 NCBI chr 1:192,195,133...192,453,546
Ensembl chr 1:192,179,019...192,453,531 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase decreases activity EXP fucoxanthin results in decreased activity of HMGCR protein CTD PMID:20519145 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO fucoxanthin results in increased expression of HMOX1 protein CTD PMID:23358145 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hunk hormonally upregulated Neu-associated kinase multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of HUNK mRNA] CTD PMID:33448797 NCBI chr16:90,182,550...90,296,443
Ensembl chr16:90,182,901...90,296,441 		JBrowse link
G Ica1l islet cell autoantigen 1-like multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of ICA1L mRNA] CTD PMID:33448797 NCBI chr 1:60,024,955...60,082,646
Ensembl chr 1:60,021,649...60,082,343 		JBrowse link
G Icam5 intercellular adhesion molecule 5, telencephalin multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of ICAM5 mRNA] CTD PMID:33448797 NCBI chr 9:20,943,372...20,950,331
Ensembl chr 9:20,943,369...20,950,332 		JBrowse link
G Ifi44 interferon-induced protein 44 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of IFI44 mRNA] CTD PMID:33448797 NCBI chr 3:151,436,559...151,455,580
Ensembl chr 3:151,436,559...151,455,597 		JBrowse link
G Iigp1 interferon inducible GTPase 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of IIGP1 mRNA] CTD PMID:33448797 NCBI chr18:60,506,688...60,525,706
Ensembl chr18:60,509,099...60,525,706 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22735499 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il23r interleukin 23 receptor multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of IL23R mRNA] CTD PMID:33448797 NCBI chr 6:67,399,906...67,468,838
Ensembl chr 6:67,399,916...67,468,839 		JBrowse link
G Il24 interleukin 24 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of IL24 mRNA] CTD PMID:33448797 NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:22735499 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irag1 inositol 1,4,5-triphosphate receptor associated 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of IRAG1 mRNA] CTD PMID:33448797 NCBI chr 7:110,467,464...110,582,116
Ensembl chr 7:110,467,473...110,581,668 		JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of IRF7 mRNA] CTD PMID:33448797 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394 		JBrowse link
G Kap kidney androgen regulated protein multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of KAP mRNA] CTD PMID:33448797 NCBI chr 6:133,826,818...133,830,630
Ensembl chr 6:133,826,814...133,830,725 		JBrowse link
G Kcnip2 Kv channel-interacting protein 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of KCNIP2 mRNA]; fucoxanthin inhibits the reaction [Glucose results in increased methylation of KCNIP2 gene] CTD PMID:33448797 NCBI chr19:45,780,785...45,804,948
Ensembl chr19:45,780,278...45,804,500 		JBrowse link
G Lpcat1 lysophosphatidylcholine acyltransferase 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of LPCAT1 mRNA] CTD PMID:33448797 NCBI chr13:73,615,332...73,664,539
Ensembl chr13:73,615,316...73,664,541 		JBrowse link
G Lrrc61 leucine rich repeat containing 61 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of LRRC61 mRNA] CTD PMID:33448797 NCBI chr 6:48,531,732...48,547,656
Ensembl chr 6:48,531,730...48,547,656 		JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of LTC4S mRNA] CTD PMID:33448797 NCBI chr11:50,127,288...50,129,378
Ensembl chr11:50,127,288...50,129,443 		JBrowse link
G Ly96 lymphocyte antigen 96 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of LY96 mRNA] CTD PMID:33448797 NCBI chr 1:16,758,680...16,779,829
Ensembl chr 1:16,758,275...16,779,835 		JBrowse link
G Mak male germ cell-associated kinase multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAK mRNA] CTD PMID:33448797 NCBI chr13:41,178,483...41,233,182
Ensembl chr13:41,178,484...41,233,182 		JBrowse link
G Mamdc2 MAM domain containing 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAMDC2 mRNA] CTD PMID:33448797 NCBI chr19:23,279,973...23,425,855
Ensembl chr19:23,279,973...23,425,806 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO fucoxanthin results in decreased activity of MAOA protein CTD PMID:31323226 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057 		JBrowse link
G Maob monoamine oxidase B decreases activity ISO fucoxanthin results in decreased activity of MAOB protein CTD PMID:31323226 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605 		JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAP3K13 mRNA] CTD PMID:33448797 NCBI chr16:21,643,923...21,752,189
Ensembl chr16:21,613,096...21,752,189 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of MAPK1 protein] CTD PMID:26418808 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of MAPK3 protein] CTD PMID:26418808 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mfsd3 major facilitator superfamily domain containing 3 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of MFSD3 mRNA] CTD PMID:33448797 NCBI chr15:76,585,742...76,588,439
Ensembl chr15:76,585,665...76,588,439 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO fucoxanthin results in decreased expression of MTOR mRNA CTD PMID:35266250 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myo7b myosin VIIB multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of MYO7B mRNA] CTD PMID:33448797 NCBI chr18:32,092,287...32,169,984
Ensembl chr18:32,092,287...32,170,014 		JBrowse link
G Nkd2 naked cuticle 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of NKD2 mRNA] CTD PMID:33448797 NCBI chr13:73,966,653...73,995,750
Ensembl chr13:73,966,653...73,995,750 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; fucoxanthin inhibits the reaction [Carrageenan results in increased expression of NOS2 protein] CTD PMID:22735499 PMID:26418808 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nrbp2 nuclear receptor binding protein 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of NRBP2 mRNA] CTD PMID:33448797 NCBI chr15:75,957,364...75,963,539
Ensembl chr15:75,957,367...75,963,476 		JBrowse link
G Ntm neurotrimin multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of NTM mRNA] CTD PMID:33448797 NCBI chr 9:28,906,045...29,874,565
Ensembl chr 9:28,906,046...29,874,437 		JBrowse link
G Nxpe4 neurexophilin and PC-esterase domain family, member 4 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of NXPE4 mRNA] CTD PMID:33448797 NCBI chr 9:48,073,302...48,311,325
Ensembl chr 9:48,073,321...48,311,325 		JBrowse link
G Oas3 2'-5' oligoadenylate synthetase 3 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of OAS3 mRNA] CTD PMID:33448797 NCBI chr 5:120,891,163...120,915,755
Ensembl chr 5:120,891,163...120,915,726 		JBrowse link
G Or1o4 olfactory receptor family 1 subfamily O member 4 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of OR1O4 mRNA] CTD PMID:33448797 NCBI chr17:37,590,392...37,591,309
Ensembl chr17:37,589,934...37,594,351 		JBrowse link
G Pacsin1 protein kinase C and casein kinase substrate in neurons 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of PACSIN1 mRNA] CTD PMID:33448797 NCBI chr17:27,874,565...27,930,092
Ensembl chr17:27,874,483...27,930,456 		JBrowse link
G Pcdh17 protocadherin 17 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of PCDH17 mRNA] CTD PMID:33448797 NCBI chr14:84,680,626...84,775,005
Ensembl chr14:84,681,003...84,776,442 		JBrowse link
G Pcdhgb6 protocadherin gamma subfamily B, 6 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of PCDHGB6 mRNA] CTD PMID:33448797 NCBI chr18:37,875,147...37,974,926
Ensembl chr18:37,875,147...37,974,926 		JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase, type 1 beta multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased methylation of PIP5K1B gene]; fucoxanthin inhibits the reaction [Glucose results in increased expression of PIP5K1B mRNA] CTD PMID:33448797 NCBI chr19:24,272,158...24,533,236
Ensembl chr19:24,272,158...24,533,236 		JBrowse link
G Pitpnm3 PITPNM family member 3 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of PITPNM3 mRNA] CTD PMID:33448797 NCBI chr11:71,938,354...72,026,715
Ensembl chr11:71,938,354...72,026,604 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP fucoxanthin results in increased expression of PPARA mRNA CTD PMID:20519145 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression EXP fucoxanthin results in decreased expression of PPARG mRNA CTD PMID:20519145 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Psen2 presenilin 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of PSEN2 mRNA] CTD PMID:33448797 NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP fucoxanthin analog affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; fucoxanthin analog affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; fucoxanthin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein] CTD PMID:22735499 PMID:26418808 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Ptgs2os prostaglandin-endoperoxide synthase 2, opposite strand multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of PTGS2OS mRNA] CTD PMID:33448797 NCBI chr 1:149,950,624...149,975,625
Ensembl chr 1:149,950,624...149,975,714 		JBrowse link
G Rab40b Rab40B, member RAS oncogene family multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of RAB40B mRNA] CTD PMID:33448797 NCBI chr11:121,246,951...121,279,080
Ensembl chr11:121,246,951...121,279,077 		JBrowse link
G Retn resistin decreases expression EXP fucoxanthin results in decreased expression of RETN protein CTD PMID:20519145 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110 		JBrowse link
G Rtp4 receptor transporter protein 4 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of RTP4 mRNA] CTD PMID:33448797 NCBI chr16:23,338,976...23,432,972
Ensembl chr16:23,339,041...23,432,972 		JBrowse link
G Shc4 SHC (Src homology 2 domain containing) family, member 4 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of SHC4 mRNA] CTD PMID:33448797 NCBI chr 2:125,469,359...125,566,085
Ensembl chr 2:125,469,367...125,566,068 		JBrowse link
G Slc16a5 solute carrier family 16 (monocarboxylic acid transporters), member 5 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of SLC16A5 mRNA] CTD PMID:33448797 NCBI chr11:115,353,231...115,365,224
Ensembl chr11:115,353,300...115,365,224 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of SLC18A2 mRNA] CTD PMID:33448797 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Slc6a18 solute carrier family 6 (neurotransmitter transporter), member 18 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of SLC6A18 mRNA] CTD PMID:33448797 NCBI chr13:73,809,869...73,826,142
Ensembl chr13:73,809,871...73,826,142 		JBrowse link
G Strip2 striatin interacting protein 2 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of STRIP2 mRNA] CTD PMID:33448797 NCBI chr 6:29,916,975...29,959,680
Ensembl chr 6:29,917,011...29,959,680 		JBrowse link
G Syn1 synapsin I multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of SYN1 mRNA] CTD PMID:33448797 NCBI chr  X:20,726,750...20,787,157
Ensembl chr  X:20,726,750...20,787,243 		JBrowse link
G Synpo2l synaptopodin 2-like multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of SYNPO2L mRNA] CTD PMID:33448797 NCBI chr14:20,709,013...20,718,422
Ensembl chr14:20,709,014...20,718,422 		JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of TGFB1I1 mRNA] CTD PMID:33448797 NCBI chr 7:127,845,963...127,852,884
Ensembl chr 7:127,845,984...127,854,871 		JBrowse link
G Thsd7a thrombospondin, type I, domain containing 7A multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of THSD7A mRNA] CTD PMID:33448797 NCBI chr 6:12,311,607...12,749,252
Ensembl chr 6:12,311,609...12,749,409 		JBrowse link
G Tmeff1 transmembrane protein with EGF-like and two follistatin-like domains 1 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of TMEFF1 mRNA]; fucoxanthin inhibits the reaction [Glucose results in increased methylation of TMEFF1 gene] CTD PMID:33448797 NCBI chr 4:48,584,583...48,663,132
Ensembl chr 4:48,585,174...48,663,131 		JBrowse link
G Tmem229b transmembrane protein 229B multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of TMEM229B mRNA] CTD PMID:33448797 NCBI chr12:79,008,569...79,054,333
Ensembl chr12:79,008,569...79,054,401 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:22735499 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of TNFSF13 mRNA] CTD PMID:33448797 NCBI chr11:69,573,403...69,576,380
Ensembl chr11:69,573,672...69,576,610 		JBrowse link
G Ttc21a tetratricopeptide repeat domain 21A multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of TTC21A mRNA] CTD PMID:33448797 NCBI chr 9:119,766,656...119,798,496
Ensembl chr 9:119,766,672...119,796,859 		JBrowse link
G Wnt7b wingless-type MMTV integration site family, member 7B multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of WNT7B mRNA] CTD PMID:33448797 NCBI chr15:85,419,638...85,466,022
Ensembl chr15:85,419,638...85,466,674 		JBrowse link
G Zfp521 zinc finger protein 521 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZFP521 mRNA] CTD PMID:33448797 NCBI chr18:13,820,070...14,105,812
Ensembl chr18:13,820,070...14,105,844 		JBrowse link
G Zfp566 zinc finger protein 566 multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in increased expression of ZFP566 mRNA] CTD PMID:33448797 NCBI chr 7:29,776,762...29,789,935
Ensembl chr 7:29,776,762...29,789,952 		JBrowse link
G Zxdc ZXD family zinc finger C multiple interactions EXP fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZXDA mRNA] CTD PMID:33448797 NCBI chr 6:90,346,460...90,380,472
Ensembl chr 6:90,346,474...90,380,472 		JBrowse link
ivacaftor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 increases activity
multiple interactions		 ISO ivacaftor results in increased activity of ABCB11 protein mutant form
ivacaftor inhibits the reaction [ABCB11 protein mutant form results in decreased transport of Taurocholic Acid]		 CTD PMID:36142670 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,960 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions
increases activity		 ISO [ivacaftor co-treated with Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin] results in increased activity of CFTR protein; [ivacaftor results in increased activity of CFTR protein mutant form] which affects the transport of Sodium; [ivacaftor results in increased activity of CFTR protein mutant form] which results in increased secretion of Chlorides; ivacaftor inhibits the reaction [Vehicle Emissions results in decreased activity of CFTR protein]
ivacaftor results in increased activity of CFTR protein; ivacaftor results in increased activity of CFTR protein mutant form		 CTD PMID:19846789 PMID:21083385 PMID:21602569 PMID:32374624 PMID:34601066 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
lumacaftor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn1 calpain 1 multiple interactions ISO CAPN1 protein affects the reaction [lumacaftor binds to CFTR protein mutant form] CTD PMID:31324722 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions
affects folding		 ISO [Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; calpain inhibitor 2 promotes the reaction [lumacaftor binds to and affects the folding of CFTR protein mutant form]; CAPN1 protein affects the reaction [lumacaftor binds to CFTR protein mutant form]; lumacaftor binds to and affects the folding of CFTR protein mutant form
lumacaftor affects the folding of CFTR protein mutant form		 CTD PMID:31324722 PMID:32374624 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22048
    role 22034
      biological role 22032
        biophysical role 13972
          membrane transport modulator 13783
            CFTR potentiator 129
              Orkambi 0
              fucoxanthin 126
              ivacaftor + 2
              lumacaftor + 2
paths to the root