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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:CFTR potentiator
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Accession:CHEBI:66902 term browser browse the term
Definition:A membrane transport modulator that restores the chloride ion transport ability of defective cystic fibrosis transmembrane conductance regulator (CFTR) genes.
Synonyms:related_synonym: CFTR potentiators;   cystic fibrosis transmembrane conductance regulator potentiator;   cystic fibrosis transmembrane conductance regulator potentiators
 xref: Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator



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fucoxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases expression ISO fucoxanthin results in increased expression of ACOX1 mRNA CTD PMID:20519145 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of ACTA1 mRNA] CTD PMID:33448797 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased methylation of ADCY7 gene]; fucoxanthin inhibits the reaction [Glucose results in increased expression of ADCY7 mRNA] CTD PMID:33448797 NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311
JBrowse link
G Ak8 adenylate kinase 8 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of AK8 mRNA] CTD PMID:33448797 NCBI chr 3:12,028,895...12,144,468
Ensembl chr 3:12,028,954...12,144,465
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of AKT1 protein] CTD PMID:26418808 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alcam activated leukocyte cell adhesion molecule multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of ALCAM mRNA] CTD PMID:33448797 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
JBrowse link
G Ankrd61 ankyrin repeat domain 61 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of ANKRD61 mRNA] CTD PMID:33448797 NCBI chr12:10,718,908...10,723,267
Ensembl chr12:10,718,908...10,723,265
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of ARHGDIB mRNA] CTD PMID:33448797 NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
JBrowse link
G Armcx6 armadillo repeat containing, X-linked 6 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of ARMCX6 mRNA] CTD PMID:33448797 NCBI chr  X:97,929,032...97,932,032
Ensembl chr  X:97,929,041...97,931,977
JBrowse link
G Atg10 autophagy related 10 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of ATG10 mRNA] CTD PMID:33448797 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of ATP2A1 mRNA] CTD PMID:33448797 NCBI chr 1:181,026,606...181,044,859 JBrowse link
G Bambi BMP and activin membrane-bound inhibitor multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of BAMBI mRNA] CTD PMID:33448797 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of BCHE mRNA] CTD PMID:33448797 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein] CTD PMID:20594983 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO fucoxanthin results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP3 protein]
CTD PMID:20594983 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP7 protein] CTD PMID:20594983 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casz1 castor zinc finger 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of CASZ1 mRNA] CTD PMID:33448797 NCBI chr 5:159,243,965...159,393,935
Ensembl chr 5:159,243,995...159,393,400
JBrowse link
G Cat catalase multiple interactions ISO fucoxanthin inhibits the reaction [Carrageenan results in decreased activity of CAT protein] CTD PMID:26418808 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccdc116 coiled-coil domain containing 116 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of CCDC116 mRNA] CTD PMID:33448797 NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607
JBrowse link
G Ccr10 C-C motif chemokine receptor 10 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of CCR10 mRNA] CTD PMID:33448797 NCBI chr10:86,108,551...86,110,988
Ensembl chr10:86,108,551...86,110,988
JBrowse link
G Cd1d1 CD1d1 molecule multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of CD1D1 mRNA] CTD PMID:33448797 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
JBrowse link
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of CELSR1 mRNA] CTD PMID:33448797 NCBI chr 7:116,987,616...117,125,035
Ensembl chr 7:116,987,605...117,125,164
JBrowse link
G Cemip cell migration inducing hyaluronidase 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of CEMIP mRNA] CTD PMID:33448797 NCBI chr 1:137,906,921...138,062,430
Ensembl chr 1:137,908,920...138,062,415
JBrowse link
G Cfp complement factor properdin multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of CFP mRNA] CTD PMID:33448797 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573
JBrowse link
G Cnn1 calponin 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of CNN1 mRNA] CTD PMID:33448797 NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098
JBrowse link
G Col7a1 collagen type VII alpha 1 chain multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of COL7A1 mRNA] CTD PMID:33448797 NCBI chr 8:109,604,877...109,637,252
Ensembl chr 8:109,604,861...109,637,252
JBrowse link
G Cpq carboxypeptidase Q multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of CPQ mRNA] CTD PMID:33448797 NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546
JBrowse link
G Crlf1 cytokine receptor-like factor 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of CRLF1 mRNA] CTD PMID:33448797 NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of CYP2E1 mRNA] CTD PMID:33448797 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Disp2 dispatched RND transporter family member 2 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of DISP2 mRNA] CTD PMID:33448797 NCBI chr 3:105,762,303...105,777,826
Ensembl chr 3:105,762,305...105,777,800
JBrowse link
G Dmtn dematin actin binding protein multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of DMTN mRNA] CTD PMID:33448797 NCBI chr15:45,677,974...45,705,601
Ensembl chr15:45,677,977...45,705,601
JBrowse link
G Drd3 dopamine receptor D3 increases activity ISO fucoxanthin results in increased activity of DRD3 protein CTD PMID:31323226 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Drd4 dopamine receptor D4 increases activity ISO fucoxanthin results in increased activity of DRD4 protein CTD PMID:31323226 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Dusp13 dual specificity phosphatase 13 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of DUSP13 mRNA] CTD PMID:33448797 NCBI chr15:2,559,720...2,575,105
Ensembl chr15:2,533,547...2,575,539
JBrowse link
G Elapor1 endosome-lysosome associated apoptosis and autophagy regulator 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of ELAPOR1 mRNA] CTD PMID:33448797 NCBI chr 2:196,089,199...196,169,055
Ensembl chr 2:196,091,646...196,168,716
JBrowse link
G Esrp1 epithelial splicing regulatory protein 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of ESRP1 mRNA] CTD PMID:33448797 NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062
JBrowse link
G Fam78b family with sequence similarity 78, member B multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of FAM78B mRNA] CTD PMID:33448797 NCBI chr13:79,162,405...79,250,958 JBrowse link
G Fam83c family with sequence similarity 83, member C multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of FAM83C mRNA] CTD PMID:33448797 NCBI chr 3:144,333,736...144,339,758
Ensembl chr 3:144,332,982...144,339,802
JBrowse link
G Fam98c family with sequence similarity 98, member C multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of FAM98C mRNA] CTD PMID:33448797 NCBI chr 1:84,452,806...84,456,414
Ensembl chr 1:84,452,814...84,456,385
JBrowse link
G Fbp2 fructose-bisphosphatase 2 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of FBP2 mRNA] CTD PMID:33448797 NCBI chr17:2,236,088...2,253,702
Ensembl chr17:2,236,336...2,253,698
JBrowse link
G Fcho1 FCH and mu domain containing endocytic adaptor 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of FCHO1 mRNA] CTD PMID:33448797 NCBI chr16:18,413,452...18,430,795
Ensembl chr16:18,413,363...18,435,104
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of FGF1 mRNA] CTD PMID:33448797 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgl2 fibrinogen-like 2 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of FGL2 mRNA] CTD PMID:33448797 NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207
JBrowse link
G Flg filaggrin decreases expression ISO fucoxanthin results in decreased expression of FLG mRNA CTD PMID:27590588 NCBI chr 2:178,888,688...178,912,731 JBrowse link
G Gask1b golgi associated kinase 1B multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of GASK1B mRNA] CTD PMID:33448797 NCBI chr 2:165,047,689...165,112,479
Ensembl chr 2:165,047,684...165,112,477
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO fucoxanthin results in increased expression of GJA1 mRNA; fucoxanthin results in increased expression of GJA1 protein CTD PMID:19737546 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gjb1 gap junction protein, beta 1 increases expression ISO fucoxanthin results in increased expression of GJB1 mRNA; fucoxanthin results in increased expression of GJB1 protein CTD PMID:19737546 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gng2 G protein subunit gamma 2 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of GNG2 mRNA] CTD PMID:33448797 NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183
JBrowse link
G Gpm6b glycoprotein m6b multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of GPM6B mRNA] CTD PMID:33448797 NCBI chr  X:28,057,788...28,204,409
Ensembl chr  X:28,059,450...28,204,211
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of GRIN1 mRNA] CTD PMID:33448797 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Gypc glycophorin C (Gerbich blood group) multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of GYPC mRNA] CTD PMID:33448797 NCBI chr18:24,160,738...24,193,408
Ensembl chr18:24,160,739...24,193,204
JBrowse link
G Hhat hedgehog acyltransferase multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of HHAT mRNA] CTD PMID:33448797 NCBI chr13:104,024,507...104,283,581
Ensembl chr13:104,010,916...104,282,893
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO fucoxanthin results in decreased activity of HMGCR protein CTD PMID:20519145 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
fucoxanthin results in increased expression of HMOX1 protein CTD PMID:23358145 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hunk hormonally upregulated Neu-associated kinase multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of HUNK mRNA] CTD PMID:33448797 NCBI chr11:29,641,051...29,758,392
Ensembl chr11:29,640,775...29,757,526
JBrowse link
G Ica1l islet cell autoantigen 1-like multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of ICA1L mRNA] CTD PMID:33448797 NCBI chr 9:61,410,959...61,469,884
Ensembl chr 9:61,412,091...61,470,134
JBrowse link
G Icam5 intercellular adhesion molecule 5 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of ICAM5 mRNA] CTD PMID:33448797 NCBI chr 8:19,567,390...19,575,588
Ensembl chr 8:19,568,600...19,575,588
JBrowse link
G Ifi44 interferon-induced protein 44 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of IFI44 mRNA] CTD PMID:33448797 NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22735499 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il23r interleukin 23 receptor multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of IL23R mRNA] CTD PMID:33448797 NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021
JBrowse link
G Il24 interleukin 24 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of IL24 mRNA] CTD PMID:33448797 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 multiple interactions ISO fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:22735499 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irag1 inositol 1,4,5-triphosphate receptor associated 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of IRAG1 mRNA] CTD PMID:33448797 NCBI chr 1:164,981,716...165,094,232
Ensembl chr 1:164,981,716...165,094,176
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of IRF7 mRNA] CTD PMID:33448797 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of KCNIP2 mRNA]; fucoxanthin inhibits the reaction [Glucose results in increased methylation of KCNIP2 gene] CTD PMID:33448797 NCBI chr 1:244,641,147...244,664,939
Ensembl chr 1:244,641,150...244,664,874
JBrowse link
G Lpcat1 lysophosphatidylcholine acyltransferase 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of LPCAT1 mRNA] CTD PMID:33448797 NCBI chr 1:29,766,070...29,816,401
Ensembl chr 1:29,766,071...29,816,401
JBrowse link
G Lrrc61 leucine rich repeat containing 61 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of LRRC61 mRNA] CTD PMID:33448797 NCBI chr 4:77,503,857...77,523,909
Ensembl chr 4:77,503,857...77,524,020
JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of LTC4S mRNA] CTD PMID:33448797 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
JBrowse link
G Ly96 lymphocyte antigen 96 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of LY96 mRNA] CTD PMID:33448797 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
JBrowse link
G Mak male germ cell-associated kinase multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAK mRNA] CTD PMID:33448797 NCBI chr17:23,683,674...23,731,125
Ensembl chr17:23,693,878...23,730,001
JBrowse link
G Mamdc2 MAM domain containing 2 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAMDC2 mRNA] CTD PMID:33448797 NCBI chr 1:220,863,959...221,016,493
Ensembl chr 1:220,863,976...221,016,354
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO fucoxanthin results in decreased activity of MAOA protein CTD PMID:31323226 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B decreases activity ISO fucoxanthin results in decreased activity of MAOB protein CTD PMID:31323226 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAP3K13 mRNA] CTD PMID:33448797 NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of MAPK1 protein] CTD PMID:26418808 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of MAPK3 protein] CTD PMID:26418808 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mfsd3 major facilitator superfamily domain containing 3 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of MFSD3 mRNA] CTD PMID:33448797 NCBI chr 7:108,419,644...108,423,469
Ensembl chr 7:108,421,350...108,423,461
JBrowse link
G Myo7b myosin VIIb multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of MYO7B mRNA] CTD PMID:33448797 NCBI chr18:23,588,307...23,669,841
Ensembl chr18:23,588,307...23,669,809
JBrowse link
G Nkd2 NKD inhibitor of WNT signaling pathway 2 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of NKD2 mRNA] CTD PMID:33448797 NCBI chr 1:29,442,898...29,470,839
Ensembl chr 1:29,441,328...29,470,821
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; fucoxanthin inhibits the reaction [Carrageenan results in increased expression of NOS2 protein] CTD PMID:22735499 PMID:26418808 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nrbp2 nuclear receptor binding protein 2 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of NRBP2 mRNA] CTD PMID:33448797 NCBI chr 7:107,798,642...107,805,230
Ensembl chr 7:107,799,497...107,805,230
JBrowse link
G Ntm neurotrimin multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of NTM mRNA] CTD PMID:33448797 NCBI chr 8:27,376,582...28,366,604
Ensembl chr 8:27,377,773...28,366,595
JBrowse link
G Nxpe4 neurexophilin and PC-esterase domain family member 4 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of NXPE4 mRNA] CTD PMID:33448797 NCBI chr 8:48,502,697...48,744,101
Ensembl chr 8:48,722,440...48,744,100
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of OAS3 mRNA] CTD PMID:33448797 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781
JBrowse link
G Pacsin1 protein kinase C and casein kinase substrate in neurons 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of PACSIN1 mRNA] CTD PMID:33448797 NCBI chr20:5,718,134...5,768,064
Ensembl chr20:5,719,857...5,765,313
JBrowse link
G Pcdh17 protocadherin 17 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of PCDH17 mRNA] CTD PMID:33448797 NCBI chr15:60,222,088...60,316,172
Ensembl chr15:60,222,004...60,313,999
JBrowse link
G Pcdhgb6 protocadherin gamma subfamily B, 6 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of PCDHGB6 mRNA] CTD PMID:33448797
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased methylation of PIP5K1B gene]; fucoxanthin inhibits the reaction [Glucose results in increased expression of PIP5K1B mRNA] CTD PMID:33448797 NCBI chr 1:221,907,220...222,183,672
Ensembl chr 1:221,914,159...222,183,672
JBrowse link
G Pitpnm3 PITPNM family member 3 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of PITPNM3 mRNA] CTD PMID:33448797 NCBI chr10:56,674,697...56,766,552
Ensembl chr10:56,676,261...56,766,584
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO fucoxanthin results in increased expression of PPARA mRNA CTD PMID:20519145 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO fucoxanthin results in decreased expression of PPARG mRNA CTD PMID:20519145 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Psen2 presenilin 2 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of PSEN2 mRNA] CTD PMID:33448797 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO fucoxanthin analog affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; fucoxanthin analog affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; fucoxanthin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein] CTD PMID:22735499 PMID:26418808 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rab40b Rab40b, member RAS oncogene family multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of RAB40B mRNA] CTD PMID:33448797 NCBI chr10:106,631,514...106,659,090
Ensembl chr10:106,631,514...106,659,090
JBrowse link
G Retn resistin decreases expression ISO fucoxanthin results in decreased expression of RETN protein CTD PMID:20519145 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Rimbp3 RIMS binding protein 3 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of RIMBP3 mRNA] CTD PMID:33448797 NCBI chr11:83,783,816...83,789,391
Ensembl chr11:83,784,244...83,789,082
JBrowse link
G Rtp4 receptor (chemosensory) transporter protein 4 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of RTP4 mRNA] CTD PMID:33448797 NCBI chr11:77,237,341...77,249,194
Ensembl chr11:77,238,216...77,335,437
JBrowse link
G Shc4 SHC adaptor protein 4 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of SHC4 mRNA] CTD PMID:33448797 NCBI chr 3:112,880,598...112,974,216
Ensembl chr 3:112,880,600...112,974,366
JBrowse link
G Slc16a5 solute carrier family 16 member 5 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of SLC16A5 mRNA] CTD PMID:33448797 NCBI chr10:100,707,434...100,721,338
Ensembl chr10:100,707,434...100,721,338
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of SLC18A2 mRNA] CTD PMID:33448797 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc6a18 solute carrier family 6 member 18 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of SLC6A18 mRNA] CTD PMID:33448797 NCBI chr 1:29,607,288...29,621,925
Ensembl chr 1:29,608,077...29,621,925
JBrowse link
G Strip2 striatin interacting protein 2 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of STRIP2 mRNA] CTD PMID:33448797 NCBI chr 4:58,536,034...58,578,279
Ensembl chr 4:58,536,055...58,578,291
JBrowse link
G Syn1 synapsin I multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of SYN1 mRNA] CTD PMID:33448797 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396
JBrowse link
G Synpo2l synaptopodin 2-like multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of SYNPO2L mRNA] CTD PMID:33448797 NCBI chr15:3,631,974...3,641,429
Ensembl chr15:3,631,834...3,641,429
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of TGFB1I1 mRNA] CTD PMID:33448797 NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080
JBrowse link
G Thsd7a thrombospondin type 1 domain containing 7A multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of THSD7A mRNA] CTD PMID:33448797 NCBI chr 4:40,461,124...40,899,345
Ensembl chr 4:40,460,814...40,899,583
JBrowse link
G Tmeff1 transmembrane protein with EGF-like and two follistatin-like domains 1 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of TMEFF1 mRNA]; fucoxanthin inhibits the reaction [Glucose results in increased methylation of TMEFF1 gene] CTD PMID:33448797 NCBI chr 5:62,910,740...62,996,494
Ensembl chr 5:62,910,740...62,996,493
JBrowse link
G Tmem229b transmembrane protein 229B multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of TMEM229B mRNA] CTD PMID:33448797 NCBI chr 6:97,771,645...97,819,582
Ensembl chr 6:97,775,332...97,819,489
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:22735499 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf13 TNF superfamily member 13 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of TNFSF13 mRNA] CTD PMID:33448797 NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042
JBrowse link
G Ttc21a tetratricopeptide repeat domain 21A multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of TTC21A mRNA] CTD PMID:33448797 NCBI chr 8:119,667,044...119,702,028
Ensembl chr 8:119,666,933...119,702,456
JBrowse link
G Wnt7b Wnt family member 7B multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of WNT7B mRNA] CTD PMID:33448797 NCBI chr 7:116,634,817...116,679,089
Ensembl chr 7:116,634,814...116,679,581
JBrowse link
G Zfp521 zinc finger protein 521 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZFP521 mRNA] CTD PMID:33448797 NCBI chr18:4,775,952...5,068,592
Ensembl chr18:4,787,295...5,068,458
JBrowse link
G Zfp566 zinc finger protein 566 multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in increased expression of ZFP566 mRNA] CTD PMID:33448797 NCBI chr 1:85,318,449...85,342,186
Ensembl chr 1:85,318,452...85,333,161
JBrowse link
G Zxdc ZXD family zinc finger C multiple interactions ISO fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZXDA mRNA] CTD PMID:33448797 NCBI chr 4:122,882,389...122,914,486
Ensembl chr 4:122,882,336...122,916,496
JBrowse link
ivacaftor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO [ivacaftor co-treated with Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin] results in increased activity of CFTR protein; [ivacaftor results in increased activity of CFTR protein mutant form] which affects the transport of Sodium; [ivacaftor results in increased activity of CFTR protein mutant form] which results in increased secretion of Chlorides
ivacaftor results in increased activity of CFTR protein; ivacaftor results in increased activity of CFTR protein mutant form
CTD PMID:19846789 PMID:21083385 PMID:21602569 PMID:32374624 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
lumacaftor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn1 calpain 1 multiple interactions ISO CAPN1 protein affects the reaction [lumacaftor binds to CFTR protein mutant form] CTD PMID:31324722 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
affects folding
ISO [Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; calpain inhibitor 2 promotes the reaction [lumacaftor binds to and affects the folding of CFTR protein mutant form]; CAPN1 protein affects the reaction [lumacaftor binds to CFTR protein mutant form]; lumacaftor binds to and affects the folding of CFTR protein mutant form
lumacaftor affects the folding of CFTR protein mutant form
CTD PMID:31324722 PMID:32374624 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biophysical role 13180
          membrane transport modulator 12995
            CFTR potentiator 117
              Orkambi 0
              fucoxanthin 115
              ivacaftor + 1
              lumacaftor + 2
paths to the root