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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:C4-dicarboxylic acid
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Accession:CHEBI:66873 term browser browse the term
Definition:Any dicarboxylic acid that contains four carbon atoms.
Synonyms:related_synonym: C4-dicarboxylic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:61336


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aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis
EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
diethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRDX2 peroxiredoxin 2 decreases activity EXP diethyl maleate results in decreased activity of PRDX2 protein CTD PMID:19208552 NCBI chr 2:66,207,829...66,211,474
Ensembl chr 2:66,207,796...66,213,567
JBrowse link
maleic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO2 aconitase 2 multiple interactions
decreases activity
EXP Curcumin inhibits the reaction [maleic acid results in decreased activity of ACO2 protein] CTD PMID:25119790 NCBI chr 5:7,014,383...7,071,023
Ensembl chr 5:7,002,124...7,070,999
JBrowse link
sarpogrelate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS protein] CTD PMID:11426759 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN protein] CTD PMID:11426759 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK1 protein] CTD PMID:11426759 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK3 protein] CTD PMID:11426759 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 879
    chemical entity 879
      group 842
        inorganic group 698
          oxo group 389
            organic oxo compound 389
              carbonyl compound 389
                dicarboxylic acids and O-substituted derivatives 13
                  dicarboxylic acid 13
                    C4-dicarboxylic acid 7
                      2-chlorosuccinic acid 0
                      2-hydroxy-3-oxosuccinic acid + 0
                      3-hydroxyaspartic acid + 0
                      3-methylthioaspartic acid + 0
                      3-thio-L-aspartic acid + 0
                      N-carbamoylaspartic acid + 0
                      N-formimidoyl-L-aspartic acid 0
                      aspartic acid + 1
                      butenedioic acid + 2
                      butynedioic acid + 0
                      dihydroxyfumaric acid 0
                      enol-oxaloacetic acid 0
                      iminoaspartic acid 0
                      malic acid + 0
                      methylmalonic acid + 0
                      oxaloacetic acid + 0
                      succinic acid + 4
                      succinic acid-d4 0
                      tetraric acid + 0
                      thiomalic acid + 0
                      trans-2,3-epoxysuccinic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 879
    subatomic particle 864
      composite particle 864
        hadron 864
          baryon 864
            nucleon 864
              atomic nucleus 864
                atom 864
                  main group element atom 854
                    p-block element atom 851
                      carbon group element atom 827
                        carbon atom 826
                          organic molecular entity 826
                            organic group 392
                              organic divalent group 390
                                organodiyl group 390
                                  carbonyl group 389
                                    carbonyl compound 389
                                      dicarboxylic acids and O-substituted derivatives 13
                                        dicarboxylic acid 13
                                          C4-dicarboxylic acid 7
                                            2-chlorosuccinic acid 0
                                            2-hydroxy-3-oxosuccinic acid + 0
                                            3-hydroxyaspartic acid + 0
                                            3-methylthioaspartic acid + 0
                                            3-thio-L-aspartic acid + 0
                                            N-carbamoylaspartic acid + 0
                                            N-formimidoyl-L-aspartic acid 0
                                            aspartic acid + 1
                                            butenedioic acid + 2
                                            butynedioic acid + 0
                                            dihydroxyfumaric acid 0
                                            enol-oxaloacetic acid 0
                                            iminoaspartic acid 0
                                            malic acid + 0
                                            methylmalonic acid + 0
                                            oxaloacetic acid + 0
                                            succinic acid + 4
                                            succinic acid-d4 0
                                            tetraric acid + 0
                                            thiomalic acid + 0
                                            trans-2,3-epoxysuccinic acid 0
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