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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:C4-dicarboxylic acid
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Accession:CHEBI:66873 term browser browse the term
Definition:Any dicarboxylic acid that contains four carbon atoms.
Synonyms:related_synonym: C4-dicarboxylic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:61336



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Ac-Asp-Glu term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Folh1 folate hydrolase 1 affects binding
multiple interactions
ISO isospaglumic acid binds to FOLH1 protein
[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]
CTD PMID:24508213 NCBI chr 7:86,365,733...86,425,171
Ensembl chr 7:86,368,185...86,425,151
JBrowse link
artesunate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions
decreases expression
EXP
ISO
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]
CTD PMID:30551460 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 affects localization ISO artesunate affects the localization of AIFM1 protein CTD PMID:24704559 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440
JBrowse link
G Ar androgen receptor multiple interactions ISO artesunate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Atg12 autophagy related 12 increases expression ISO Artesunate results in increased expression of ATG12 mRNA CTD PMID:30551460 NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647
JBrowse link
G Atg3 autophagy related 3 increases expression ISO Artesunate results in increased expression of ATG3 mRNA CTD PMID:30551460 NCBI chr16:44,979,192...45,008,901
Ensembl chr16:44,979,148...45,008,901
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Artesunate results in increased expression of ATG5 mRNA CTD PMID:30551460 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
ISO Artesunate results in increased expression of BAX protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions
ISO Artesunate results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]
[1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bst1 bone marrow stromal cell antigen 1 increases response to substance ISO BST1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:43,976,235...44,000,810
Ensembl chr 5:43,976,227...44,001,328
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
ISO artesunate results in increased activity of CASP3 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]
CTD PMID:19513562 PMID:24704559 PMID:33002460 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 affects expression ISO artesunate affects the expression of CASP9 protein CTD PMID:24704559 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase increases expression
decreases response to substance
ISO artesunate results in increased expression of CAT protein
CAT protein results in decreased susceptibility to artesunate
CTD PMID:19513562 PMID:20144594 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 decreases response to substance ISO CCT2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:116,886,902...116,899,757
Ensembl chr10:116,886,906...116,899,719
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation
multiple interactions
ISO Artesunate results in increased phosphorylation of CHEK1 protein
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein]
CTD PMID:31664825 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases response to substance ISO CLIP4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr17:72,076,674...72,171,205
Ensembl chr17:72,075,468...72,171,268
JBrowse link
G Coq8a coenzyme Q8A decreases response to substance ISO COQ8A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:179,992,803...180,023,585
Ensembl chr 1:179,992,803...180,027,167
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] CTD PMID:29031619 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 affects metabolic processing ISO CYP2A6 protein affects the metabolism of Artesunate CTD PMID:12920490 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
JBrowse link
G Dbh dopamine beta hydroxylase increases response to substance ISO DBH mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212
JBrowse link
G Des desmin decreases expression
multiple interactions
ISO Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]
CTD PMID:30551460 NCBI chr 1:75,336,936...75,345,223
Ensembl chr 1:75,336,973...75,345,223
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO artesunate binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO artesunate results in increased expression of FAS protein CTD PMID:19513562 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Flna filamin, alpha increases response to substance ISO FLNA mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr  X:73,267,067...73,293,787
Ensembl chr  X:73,267,067...73,293,426
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA]
Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein
CTD PMID:30551460 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Fth1 ferritin heavy polypeptide 1 decreases expression
multiple interactions
ISO Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
CTD PMID:30551460 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
JBrowse link
G Fzd7 frizzled class receptor 7 increases response to substance ISO FZD7 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:59,521,306...59,526,114
Ensembl chr 1:59,521,583...59,526,114
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects response to substance
decreases response to substance
ISO GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate
CTD PMID:15796179 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit decreases response to substance ISO GCLM mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases activity
EXP
ISO
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]
Artesunate results in decreased activity of GPX4 protein
CTD PMID:30551460 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G Gstm4 glutathione S-transferase, mu 4 affects response to substance ISO GSTM4 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 3:107,937,887...107,952,495
Ensembl chr 3:107,947,724...107,952,210
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases expression ISO artesunate results in decreased expression of GSTP1 protein CTD PMID:19513562 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Gstz1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) affects response to substance ISO GSTZ1 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr12:87,192,102...87,211,497
Ensembl chr12:87,193,939...87,211,497
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein] CTD PMID:31664825 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:27474069 PMID:30031708 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:27474069 PMID:30031708 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) increases response to substance ISO ITGB1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases lipidation
multiple interactions
ISO Artesunate results in increased lipidation of MAP1LC3B protein
3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]
CTD PMID:33002460 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 affects response to substance ISO MGST3 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 1:167,199,535...167,221,410
Ensembl chr 1:167,199,535...167,221,410
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:29031619 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]
CTD PMID:29031619 PMID:30551460 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:27474069 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase decreases response to substance ISO MTHFD2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 6:83,282,686...83,302,926
Ensembl chr 6:83,282,673...83,302,890
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions
ISO Artesunate results in decreased phosphorylation of MTOR protein
acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]
CTD PMID:33002460 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] CTD PMID:30031708 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
JBrowse link
G Naca nascent polypeptide-associated complex alpha polypeptide decreases response to substance ISO NACA mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:127,869,144...127,884,506
Ensembl chr10:127,871,444...127,884,506
JBrowse link
G Nckap1 NCK-associated protein 1 increases response to substance ISO NCKAP1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:80,330,856...80,411,526
Ensembl chr 2:80,330,856...80,411,724
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein
CTD PMID:30551460 NCBI chr14:31,881,884...31,901,210
Ensembl chr14:31,881,822...31,901,812
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization ISO artesunate affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions
ISO Artesunate results in increased cleavage of PARP1 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]
CTD PMID:24704559 PMID:33002460 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29031619 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pgr progesterone receptor multiple interactions ISO artesunate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein CTD PMID:30551460 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] CTD PMID:27474069 PMID:30031708 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Artesunate results in increased phosphorylation of RPA2 protein CTD PMID:31664825 NCBI chr 4:132,495,671...132,506,057
Ensembl chr 4:132,495,643...132,506,063
JBrowse link
G Rpl41 ribosomal protein L41 decreases response to substance ISO RPL41 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:128,383,979...128,385,037
Ensembl chr10:128,383,983...128,385,174
JBrowse link
G Rpl6 ribosomal protein L6 decreases response to substance ISO RPL6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:121,342,564...121,347,304
Ensembl chr 5:121,342,544...121,347,304
JBrowse link
G Rpl7 ribosomal protein L7 decreases response to substance ISO RPL7 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:16,171,519...16,174,657
Ensembl chr 1:16,171,519...16,174,886
JBrowse link
G Rps12 ribosomal protein S12 decreases response to substance ISO RPS12 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:23,661,042...23,664,297
Ensembl chr10:23,661,081...23,663,173
JBrowse link
G Rps15a ribosomal protein S15A decreases response to substance ISO RPS15A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:117,703,597...117,715,370
Ensembl chr 7:117,703,595...117,715,411
JBrowse link
G Rps6 ribosomal protein S6 decreases response to substance ISO RPS6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649
JBrowse link
G Slc25a19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 decreases response to substance ISO SLC25A19 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr11:115,504,991...115,519,122
Ensembl chr11:115,505,004...115,519,121
JBrowse link
G Sp1 trans-acting transcription factor 1 decreases expression ISO artesunate results in decreased expression of SP1 protein CTD PMID:19513562 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839
JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions
ISO Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]
CTD PMID:30551460 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Srsf2 serine and arginine-rich splicing factor 2 decreases response to substance ISO SRSF2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr11:116,740,723...116,744,511
Ensembl chr11:116,740,727...116,743,920
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions
increases expression
ISO Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA] CTD PMID:30551460 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:27474069 PMID:30031708 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects response to substance
multiple interactions
ISO TPT1 protein affects the susceptibility to artesunate
Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:15878303 PMID:33259807 NCBI chr14:76,082,771...76,085,743
Ensembl chr14:76,082,533...76,085,965
JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions
ISO Artesunate results in increased expression of TP53 protein
Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:33259807 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases response to substance ISO TUFM mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:126,086,445...126,089,903
Ensembl chr 7:126,086,533...126,089,903
JBrowse link
G Ulk1 unc-51 like kinase 1 increases phosphorylation
multiple interactions
ISO Artesunate results in increased phosphorylation of ULK1 protein
acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]
CTD PMID:33002460 NCBI chr 5:110,932,355...110,957,991
Ensembl chr 5:110,932,354...110,957,963
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] CTD PMID:29031619 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Yy1 YY1 transcription factor decreases expression ISO artesunate results in decreased expression of YY1 protein CTD PMID:19513562 NCBI chr12:108,758,841...108,786,074
Ensembl chr12:108,758,899...108,786,074
JBrowse link
G Zbtb4 zinc finger and BTB domain containing 4 increases response to substance ISO ZBTB4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr11:69,656,738...69,674,852
Ensembl chr11:69,656,738...69,674,849
JBrowse link
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCA1 mRNA CTD PMID:23783067 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCB4 mRNA CTD PMID:23783067 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
JBrowse link
G Abcd1 ATP-binding cassette, sub-family D member 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of ABCD1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD1 mRNA CTD PMID:23783067 NCBI chr  X:72,760,203...72,782,140
Ensembl chr  X:72,760,203...72,782,140
JBrowse link
G Abcd2 ATP-binding cassette, sub-family D member 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD2 mRNA CTD PMID:23783067 NCBI chr15:91,029,874...91,076,013
Ensembl chr15:91,030,074...91,076,002
JBrowse link
G Acaa1a acetyl-Coenzyme A acyltransferase 1A multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACAA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1A mRNA CTD PMID:23783067 NCBI chr 9:119,170,113...119,179,361
Ensembl chr 9:119,168,742...119,179,365
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1B mRNA CTD PMID:23783067 NCBI chr 9:118,977,111...118,986,149
Ensembl chr 9:118,977,091...118,986,161
JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACACB mRNA CTD PMID:23783067 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822
JBrowse link
G Acads acyl-Coenzyme A dehydrogenase, short chain multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADS mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADS mRNA CTD PMID:23783067 NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405
JBrowse link
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADVL mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADVL mRNA CTD PMID:23783067 NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237
JBrowse link
G Ache acetylcholinesterase decreases activity ISO Aspartame metabolite results in decreased activity of ACHE protein CTD PMID:16129618 PMID:17580119 PMID:17673349 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Aco1 aconitase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACO1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACO1 mRNA CTD PMID:23783067 NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338
JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACOT1 mRNA CTD PMID:23783067 NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ADGRE1 mRNA CTD PMID:23783067 NCBI chr17:57,665,650...57,790,527
Ensembl chr17:57,665,691...57,790,527
JBrowse link
G Agt angiotensinogen decreases expression ISO Aspartame results in decreased expression of AGT mRNA CTD PMID:31655124 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Aspartame results in decreased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation ISO Aspartame results in increased phosphorylation of AKT1 protein CTD PMID:33992720 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ALOX15 mRNA CTD PMID:23783067 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857
JBrowse link
G Apoe apolipoprotein E decreases expression ISO Aspartame results in decreased expression of APOE mRNA CTD PMID:31655124 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO
EXP
[Aspartame co-treated with Methotrexate] results in increased expression of BAX mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of BAX protein
Aspartame results in increased expression of BAX mRNA
[Fats, Unsaturated co-treated with Aspartame] affects the expression of BAX mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of BAX mRNA
CTD PMID:23783067 PMID:25009784 PMID:32951320 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO
EXP
[Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 mRNA; [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 protein
Aspartame results in decreased expression of BCL2 mRNA
CTD PMID:25009784 PMID:32951320 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Cabp2 calcium binding protein 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CABP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CABP2 mRNA CTD PMID:23783067 NCBI chr19:4,131,469...4,137,340
Ensembl chr19:4,131,578...4,137,340
JBrowse link
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1A mRNA CTD PMID:23783067 NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875
JBrowse link
G Cacna1i calcium channel, voltage-dependent, alpha 1I subunit multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1I mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1I mRNA CTD PMID:23783067 NCBI chr15:80,171,439...80,282,493
Ensembl chr15:80,171,439...80,282,480
JBrowse link
G Cacna2d4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA2D4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA2D4 mRNA CTD PMID:23783067 NCBI chr 6:119,213,435...119,329,368
Ensembl chr 6:119,213,487...119,329,368
JBrowse link
G Cacnb2 calcium channel, voltage-dependent, beta 2 subunit multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNB2 mRNA CTD PMID:23783067 NCBI chr 2:14,608,672...14,993,622
Ensembl chr 2:14,607,899...14,992,719
JBrowse link
G Cacng4 calcium channel, voltage-dependent, gamma subunit 4 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG4 mRNA CTD PMID:23783067 NCBI chr11:107,623,183...107,685,532
Ensembl chr11:107,623,183...107,685,383
JBrowse link
G Cacng8 calcium channel, voltage-dependent, gamma subunit 8 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG8 mRNA CTD PMID:23783067 NCBI chr 7:3,442,558...3,464,782
Ensembl chr 7:3,439,199...3,464,164
JBrowse link
G Calhm2 calcium homeostasis modulator family member 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CALHM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALHM2 mRNA CTD PMID:23783067 NCBI chr19:47,120,671...47,126,733
Ensembl chr19:47,093,792...47,126,733
JBrowse link
G Calr3 calreticulin 3 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CALR3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALR3 mRNA CTD PMID:23783067 NCBI chr 8:73,178,020...73,197,638
Ensembl chr 8:73,178,020...73,197,714
JBrowse link
G Cant1 calcium activated nucleotidase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CANT1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CANT1 mRNA CTD PMID:23783067 NCBI chr11:118,297,115...118,309,971
Ensembl chr11:118,297,115...118,309,912
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO
EXP
[Aspartame co-treated with Methotrexate] results in increased expression of CASP3 mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 protein modified form
Aspartame results in increased expression of CASP3 mRNA
CTD PMID:25009784 PMID:32951320 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CASP9 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CASP9 mRNA CTD PMID:23783067 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO
EXP
[Aspartame co-treated with Methotrexate] results in increased activity of CAT protein
Aspartame results in decreased activity of CAT protein
CTD PMID:25009784 PMID:32951320 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] results in increased expression of CCL2 protein; [Sodium Glutamate co-treated with Aspartame] inhibits the reaction [Fats, Unsaturated results in increased expression of CCL2 protein] CTD PMID:23783067 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO Aspartame results in decreased expression of CDH1 protein CTD PMID:33992720 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A affects localization
multiple interactions
ISO Aspartame affects the localization of CDKN1A protein
TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]
CTD PMID:33992720 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions
decreases expression
EXP
ISO
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CDKN1B mRNA
Aspartame results in decreased expression of CDKN1B protein
CTD PMID:23783067 PMID:33992720 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Cherp calcium homeostasis endoplasmic reticulum protein multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CHERP mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CHERP mRNA CTD PMID:23783067 NCBI chr 8:73,214,327...73,229,077
Ensembl chr 8:73,214,333...73,229,070
JBrowse link
G Cmc1 C-X9-C motif containing 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CMC1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CMC1 mRNA CTD PMID:23783067 NCBI chr 9:117,893,051...117,979,264
Ensembl chr 9:117,893,590...117,979,245
JBrowse link
G Cox11 cytochrome c oxidase assembly protein 11, copper chaperone multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX11 mRNA CTD PMID:23783067 NCBI chr11:90,529,010...90,536,803
Ensembl chr11:90,528,999...90,535,757
JBrowse link
G Cox7a1 cytochrome c oxidase subunit 7A1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX7A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX7A1 mRNA CTD PMID:23783067 NCBI chr 7:29,883,596...29,885,455
Ensembl chr 7:29,883,569...29,885,503
JBrowse link
G Cox8b cytochrome c oxidase subunit 8B multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX8B mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX8B mRNA CTD PMID:23783067 NCBI chr 7:140,478,855...140,480,359
Ensembl chr 7:140,478,858...140,480,359
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CPT1B mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1B mRNA CTD PMID:23783067 NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1C mRNA CTD PMID:23783067 NCBI chr 7:44,607,907...44,624,304
Ensembl chr 7:44,608,796...44,624,275
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CREB1 mRNA CTD PMID:23783067 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CSF1 mRNA CTD PMID:23783067 NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity ISO Aspartame results in increased activity of CYP1A1 protein CTD PMID:16937917 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity ISO Aspartame results in increased activity of CYP1A2 protein CTD PMID:16937917 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases activity ISO Aspartame results in increased activity of CYP2B2 protein CTD PMID:16937917 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Aspartame results in increased expression of and results in increased activity of CYP2E1 protein CTD PMID:16937917 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CYP4A10 mRNA CTD PMID:23783067 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846
JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CYP4A14 mRNA CTD PMID:23783067 NCBI chr 4:115,343,397...115,353,355
Ensembl chr 4:115,343,397...115,353,339
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of DIABLO mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DIABLO mRNA CTD PMID:23783067 NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239
JBrowse link
G Dnajc27 DnaJ heat shock protein family (Hsp40) member C27 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of DNAJC27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DNAJC27 mRNA CTD PMID:23783067 NCBI chr12:4,132,569...4,174,140
Ensembl chr12:4,132,583...4,160,606
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of E2F1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of E2F1 mRNA CTD PMID:23783067 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
JBrowse link
G Edn2 endothelin 2 decreases expression ISO Aspartame results in decreased expression of EDN2 mRNA CTD PMID:31655124 NCBI chr 4:120,018,403...120,024,557
Ensembl chr 4:120,018,403...120,024,557
JBrowse link
G Ednra endothelin receptor type A decreases expression ISO Aspartame results in decreased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093
JBrowse link
G Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of EHHADH mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EHHADH mRNA CTD PMID:23783067 NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of EPHX2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EPHX2 mRNA CTD PMID:23783067 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949
JBrowse link
G F2 coagulation factor II decreases activity ISO Aspartame analog results in decreased activity of F2 protein; Aspartame results in decreased activity of F2 protein CTD PMID:15572260 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Aspartame results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525
JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of FOXO3 mRNA CTD PMID:23783067 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
JBrowse link
G Fshb follicle stimulating hormone beta decreases expression EXP Aspartame results in decreased expression of FSHB protein CTD PMID:32951320 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GADD45B mRNA CTD PMID:23783067 NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038
JBrowse link
G Gfm2 G elongation factor, mitochondrial 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of GFM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GFM2 mRNA CTD PMID:23783067 NCBI chr13:97,274,445...97,317,710
Ensembl chr13:97,274,445...97,317,703
JBrowse link
G Gip gastric inhibitory polypeptide multiple interactions EXP Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]; Sodium Glutamate inhibits the reaction [Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]] CTD PMID:23783067 NCBI chr11:95,915,358...95,921,657
Ensembl chr11:95,915,371...95,921,657
JBrowse link
G Gli1 GLI-Kruppel family member GLI1 affects localization
multiple interactions
ISO Aspartame affects the localization of GLI1 protein
TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]
CTD PMID:33992720 NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843
JBrowse link
G Gli2 GLI-Kruppel family member GLI2 decreases expression ISO Aspartame results in decreased expression of GLI2 protein CTD PMID:33992720 NCBI chr 1:118,761,791...118,987,578
Ensembl chr 1:118,761,862...118,981,349
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO Aspartame results in increased phosphorylation of GSK3B protein CTD PMID:33992720 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gsr glutathione reductase multiple interactions ISO [Aspartame co-treated with Methotrexate] results in decreased activity of GSR protein CTD PMID:25009784 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHA mRNA CTD PMID:23783067 NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHB mRNA CTD PMID:23783067 NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC1 mRNA CTD PMID:23783067 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC5 mRNA CTD PMID:23783067 NCBI chr11:102,085,244...102,120,968
Ensembl chr11:102,085,258...102,120,992
JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HGF mRNA CTD PMID:23783067 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150
JBrowse link
G Hras Harvey rat sarcoma virus oncogene increases expression EXP Aspartame results in increased expression of HRAS CTD PMID:17354619 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918
JBrowse link
G Hspg2 perlecan (heparan sulfate proteoglycan 2) multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HSPG2 mRNA CTD PMID:23783067 NCBI chr 4:137,196,062...137,297,941
Ensembl chr 4:137,196,080...137,297,941
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of IDH2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IDH2 mRNA CTD PMID:23783067 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
JBrowse link
G Il11 interleukin 11 decreases expression ISO Aspartame results in decreased expression of IL11 mRNA CTD PMID:31655124 NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Aspartame results in increased expression of IL1B mRNA CTD PMID:31655124 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il3 interleukin 3 decreases expression ISO Aspartame results in decreased expression of IL3 mRNA CTD PMID:31655124 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103
JBrowse link
G Il6 interleukin 6 increases secretion ISO Aspartame results in increased secretion of IL6 protein CTD PMID:20837131 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Immt inner membrane protein, mitochondrial multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of IMMT mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IMMT mRNA CTD PMID:23783067 NCBI chr 6:71,806,200...71,852,250
Ensembl chr 6:71,808,315...71,854,372
JBrowse link
G Ins2 insulin II increases expression
multiple interactions
ISO
EXP
Aspartame results in increased expression of INS protein
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] results in increased expression of INS2 protein; Aspartame inhibits the reaction [Fats, Unsaturated results in increased expression of INS2 protein]
CTD PMID:1805284 PMID:23783067 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Kdr kinase insert domain protein receptor increases secretion ISO Aspartame results in increased secretion of KDR protein CTD PMID:20837131 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
JBrowse link
G Lep leptin decreases expression
multiple interactions
ISO
EXP
Aspartame results in decreased expression of LEP protein
[Fats, Unsaturated co-treated with Aspartame] results in increased expression of LEP protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of LEP protein]
CTD PMID:11890951 PMID:23783067 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Lhb luteinizing hormone beta decreases expression EXP Aspartame results in decreased expression of LHB protein CTD PMID:32951320 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
JBrowse link
G Lipg lipase, endothelial multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LIPG mRNA CTD PMID:23783067 NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334
JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP1 mRNA CTD PMID:23783067 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017
JBrowse link
G Lrp2 low density lipoprotein receptor-related protein 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP2 mRNA CTD PMID:23783067 NCBI chr 2:69,254,679...69,416,373
Ensembl chr 2:69,254,684...69,416,409
JBrowse link
G Lrp4 low density lipoprotein receptor-related protein 4 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP4 mRNA CTD PMID:23783067 NCBI chr 2:91,287,794...91,344,246
Ensembl chr 2:91,287,856...91,344,124
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation ISO Aspartame results in increased phosphorylation of MAPK1 protein CTD PMID:20837131 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation ISO Aspartame results in increased phosphorylation of MAPK3 protein CTD PMID:20837131 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mcu mitochondrial calcium uniporter multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MCU mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MCU mRNA CTD PMID:23783067 NCBI chr10:59,282,806...59,453,231
Ensembl chr10:59,282,806...59,452,514
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA CTD PMID:23783067 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Med23 mediator complex subunit 23 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MED23 mRNA CTD PMID:23783067 NCBI chr10:24,745,889...24,789,358
Ensembl chr10:24,745,884...24,789,579
JBrowse link
G Mef2d myocyte enhancer factor 2D multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MEF2D mRNA CTD PMID:23783067 NCBI chr 3:88,049,248...88,079,398
Ensembl chr 3:88,049,679...88,079,393
JBrowse link
G Micos10 mitochondrial contact site and cristae organizing system subunit 10 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MINOS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MINOS1 mRNA CTD PMID:23783067 NCBI chr 4:138,829,125...138,858,667
Ensembl chr 4:138,829,125...138,858,424
JBrowse link
G Micu1 mitochondrial calcium uptake 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MICU1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MICU1 mRNA CTD PMID:23783067 NCBI chr10:59,538,385...59,699,956
Ensembl chr10:59,538,299...59,699,954
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL20 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL20 mRNA CTD PMID:23783067 NCBI chr 4:155,887,335...155,893,288
Ensembl chr 4:155,887,335...155,894,432
JBrowse link
G Mrpl3 mitochondrial ribosomal protein L3 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL3 mRNA CTD PMID:23783067 NCBI chr 9:104,930,394...104,954,665
Ensembl chr 9:104,930,438...104,957,087
JBrowse link
G Mrps12 mitochondrial ribosomal protein S12 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS12 mRNA CTD PMID:23783067 NCBI chr 7:28,439,066...28,441,246
Ensembl chr 7:28,439,066...28,441,245
JBrowse link
G Mrps24 mitochondrial ribosomal protein S24 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS24 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS24 mRNA CTD PMID:23783067 NCBI chr11:5,653,982...5,657,701
Ensembl chr11:5,653,983...5,665,680
JBrowse link
G Mrps27 mitochondrial ribosomal protein S27 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS27 mRNA CTD PMID:23783067 NCBI chr13:99,481,275...99,552,070
Ensembl chr13:99,481,294...99,552,070
JBrowse link
G Mrps7 mitchondrial ribosomal protein S7 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS7 mRNA CTD PMID:23783067 NCBI chr11:115,494,966...115,498,862
Ensembl chr11:115,494,751...115,498,862
JBrowse link
G Mtfp1 mitochondrial fission process 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MTFP1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MTFP1 mRNA CTD PMID:23783067 NCBI chr11:4,041,481...4,045,431
Ensembl chr11:4,041,480...4,045,445
JBrowse link
G Myc myelocytomatosis oncogene increases expression EXP
ISO
Aspartame results in increased expression of MYC
Aspartame results in increased expression of MYC protein
CTD PMID:17354619 PMID:33992720 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NCOR1 mRNA CTD PMID:23783067 NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367
JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA12 mRNA CTD PMID:23783067 NCBI chr10:94,034,897...94,057,302
Ensembl chr10:94,034,582...94,057,305
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA5 mRNA CTD PMID:23783067 NCBI chr 6:24,518,661...24,527,689
Ensembl chr 6:24,518,665...24,528,012
JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB10 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB10 mRNA CTD PMID:23783067 NCBI chr17:24,941,034...24,943,397
Ensembl chr17:24,941,034...24,943,452
JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB2 mRNA CTD PMID:23783067 NCBI chr 6:39,569,499...39,576,777
Ensembl chr 6:39,569,508...39,580,316
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB6 mRNA CTD PMID:23783067 NCBI chr 4:40,270,591...40,279,421
Ensembl chr 4:40,270,591...40,279,421
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS1 mRNA CTD PMID:23783067 NCBI chr 1:63,182,751...63,215,981
Ensembl chr 1:63,182,755...63,215,992
JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase core subunit S6 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS6 mRNA CTD PMID:23783067 NCBI chr13:73,467,995...73,476,574
Ensembl chr13:73,467,957...73,476,661
JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFV1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFV1 mRNA CTD PMID:23783067 NCBI chr19:4,057,499...4,062,755
Ensembl chr19:4,057,384...4,062,806
JBrowse link
G Nf1 neurofibromin 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NF1 mRNA CTD PMID:23783067 NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438
JBrowse link
G Notch1 notch 1 multiple interactions
affects localization
EXP
ISO
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOTCH1 mRNA
Aspartame affects the localization of NOTCH1 protein modified form
TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form]
CTD PMID:23783067 PMID:33992720 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOX1 mRNA CTD PMID:23783067 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705
JBrowse link
G Nppb natriuretic peptide type B decreases expression ISO Aspartame results in decreased expression of NPPB mRNA CTD PMID:31655124 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662
JBrowse link
G Npy neuropeptide Y decreases expression ISO Aspartame results in decreased expression of NPY protein CTD PMID:11890951 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NR1I3 mRNA CTD PMID:23783067 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
JBrowse link
G Onecut1 one cut domain, family member 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ONECUT1 mRNA CTD PMID:23783067 NCBI chr 9:74,769,203...74,796,930
Ensembl chr 9:74,769,203...74,799,063
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 alpha 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHA2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHA2 mRNA CTD PMID:23783067 NCBI chr 3:140,915,765...140,918,116
Ensembl chr 3:140,915,765...140,918,116
JBrowse link
G Pdhb pyruvate dehydrogenase (lipoamide) beta multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHB mRNA CTD PMID:23783067 NCBI chr14:14,296,470...14,303,782
Ensembl chr14:14,296,748...14,303,777
JBrowse link
G Pex1 peroxisomal biogenesis factor 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX1 mRNA CTD PMID:23783067 NCBI chr 5:3,646,066...3,687,230
Ensembl chr 5:3,646,066...3,687,232
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX11A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX11A mRNA CTD PMID:23783067 NCBI chr 7:79,385,705...79,392,879
Ensembl chr 7:79,385,705...79,392,879
JBrowse link
G Pex13 peroxisomal biogenesis factor 13 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX13 mRNA CTD PMID:23783067 NCBI chr11:23,597,283...23,615,883
Ensembl chr11:23,596,479...23,615,959
JBrowse link
G Pex5 peroxisomal biogenesis factor 5 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX5 mRNA CTD PMID:23783067 NCBI chr 6:124,373,774...124,392,878
Ensembl chr 6:124,373,775...124,392,026
JBrowse link
G Pex7 peroxisomal biogenesis factor 7 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX7 mRNA CTD PMID:23783067 NCBI chr10:19,735,836...19,783,420
Ensembl chr10:19,729,646...19,783,435
JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB2 mRNA CTD PMID:23783067 NCBI chr 1:130,616,780...130,656,990
Ensembl chr 1:130,616,919...130,656,990
Ensembl chr 1:130,616,919...130,656,990
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB4 mRNA CTD PMID:23783067 NCBI chr 9:108,817,336...108,861,302
Ensembl chr 9:108,820,846...108,861,296
JBrowse link
G Pld2 phospholipase D2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLD2 mRNA CTD PMID:23783067 NCBI chr11:70,430,318...70,448,936
Ensembl chr11:70,430,890...70,448,936
JBrowse link
G Plg plasminogen decreases expression ISO Aspartame results in decreased expression of PLG mRNA CTD PMID:31655124 NCBI chr17:12,597,496...12,638,271
Ensembl chr17:12,597,495...12,638,272
JBrowse link
G Plxnd1 plexin D1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLXND1 mRNA CTD PMID:23783067 NCBI chr 6:115,931,772...115,972,300
Ensembl chr 6:115,931,772...115,971,966
JBrowse link
G Polg polymerase (DNA directed), gamma multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of POLG mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of POLG mRNA CTD PMID:23783067 NCBI chr 7:79,095,979...79,117,659
Ensembl chr 7:79,095,979...79,116,110
JBrowse link
G Pomc pro-opiomelanocortin-alpha increases expression ISO Aspartame results in increased expression of POMC protein alternative form CTD PMID:1805284 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 affects localization ISO Aspartame affects the localization of POU5F1 protein CTD PMID:33992720 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARA mRNA CTD PMID:23783067 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Ppard peroxisome proliferator activator receptor delta multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARD mRNA CTD PMID:23783067 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARG mRNA CTD PMID:23783067 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARGC1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARGC1A mRNA CTD PMID:23783067 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Prdx5 peroxiredoxin 5 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PRDX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PRDX5 mRNA CTD PMID:23783067 NCBI chr19:6,884,065...6,887,474
Ensembl chr19:6,884,065...6,887,474
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ROCK1 mRNA CTD PMID:23783067 NCBI chr18:10,064,401...10,182,225
Ensembl chr18:10,064,401...10,182,045
JBrowse link
G S100a13 S100 calcium binding protein A13 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A13 mRNA CTD PMID:23783067 NCBI chr 3:90,421,542...90,431,888
Ensembl chr 3:90,421,742...90,431,888
JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A8 mRNA CTD PMID:23783067 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342
JBrowse link
G Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of SDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SDHB mRNA CTD PMID:23783067 NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT1 mRNA CTD PMID:23783067 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Sirt2 sirtuin 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA CTD PMID:23783067 NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086
JBrowse link
G Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 decreases activity ISO Aspartame results in decreased activity of SLC15A1 protein CTD PMID:15846457 NCBI chr14:121,697,033...121,742,666
Ensembl chr14:121,697,033...121,742,664
JBrowse link
G Slc4a2 solute carrier family 4 (anion exchanger), member 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC4A2 mRNA CTD PMID:23783067 NCBI chr 5:24,628,834...24,645,945
Ensembl chr 5:24,628,835...24,645,948
JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of SLC8A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC8A1 mRNA CTD PMID:23783067 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806
JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 affects localization ISO Aspartame affects the localization of SOX2 protein CTD PMID:33992720 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610
JBrowse link
G Srebf2 sterol regulatory element binding factor 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SREBF2 mRNA CTD PMID:23783067 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of STAT3 mRNA CTD PMID:23783067 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Surf1 surfeit gene 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of SURF1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SURF1 mRNA CTD PMID:23783067 NCBI chr 2:26,803,390...26,806,667
Ensembl chr 2:26,803,393...26,806,542
JBrowse link
G Tas1r1 taste receptor, type 1, member 1 increases expression
multiple interactions
ISO Aspartame results in increased expression of TAS1R1 protein
Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form]
CTD PMID:33992720 NCBI chr 4:152,112,371...152,122,947
Ensembl chr 4:152,112,371...152,123,025
JBrowse link
G Tas1r2 taste receptor, type 1, member 2 multiple interactions
affects binding
ISO Aspartame binds to and results in increased activity of TAS1R2 protein; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]; Aspartame binds to TAS1R2 protein
CTD PMID:15353592 PMID:17168764 PMID:17935609 PMID:20173092 PMID:33992720 NCBI chr 4:139,380,849...139,397,591
Ensembl chr 4:139,380,849...139,397,591
JBrowse link
G Tas1r3 taste receptor, type 1, member 3 affects binding
decreases expression
multiple interactions
ISO Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]
Aspartame results in decreased expression of TAS1R3 protein
Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
CTD PMID:17168764 PMID:17935609 PMID:33992720 NCBI chr 4:155,943,725...155,947,810
Ensembl chr 4:155,943,725...155,947,819
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of TFAM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TFAM mRNA CTD PMID:23783067 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of THBS1 mRNA CTD PMID:23783067 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] results in increased expression of TNF protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of TNF protein] CTD PMID:23783067 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions
EXP Aspartame results in increased expression of TRP53; Aspartame results in increased expression of TRP53 mRNA
[Fats, Unsaturated co-treated with Aspartame] affects the expression of TRP53 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TRP53 mRNA
CTD PMID:17354619 PMID:23783067 PMID:32951320 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity ISO Aspartame results in increased activity of TRPV1 protein CTD PMID:17567713 PMID:18804451 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of TUFM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TUFM mRNA CTD PMID:23783067 NCBI chr 7:126,086,445...126,089,903
Ensembl chr 7:126,086,533...126,089,903
JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of UCP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UCP2 mRNA CTD PMID:23783067 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of UQCR11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UQCR11 mRNA CTD PMID:23783067 NCBI chr10:80,238,831...80,242,655
Ensembl chr10:80,238,831...80,242,664
JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion ISO Aspartame results in increased secretion of VEGFA protein CTD PMID:20837131 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vim vimentin increases expression ISO Aspartame results in increased expression of VIM protein CTD PMID:33992720 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of XDH mRNA CTD PMID:23783067 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191
JBrowse link
citraconic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 affects localization ISO citraconic acid affects the localization of BACH1 protein CTD PMID:27277809 NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234
JBrowse link
G Foxm1 forkhead box M1 increases expression ISO citraconic acid results in increased expression of FOXM1 protein CTD PMID:28289076 NCBI chr 6:128,339,957...128,352,849
Ensembl chr 6:128,339,930...128,353,109
JBrowse link
G Fth1 ferritin heavy polypeptide 1 increases expression ISO citraconic acid results in increased expression of FTH1 protein CTD PMID:28289076 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression
multiple interactions
ISO citraconic acid results in increased expression of FTL protein
citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein]
CTD PMID:28289076 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO
EXP
citraconic acid results in increased expression of GCLC protein
citraconic acid results in increased expression of GCLC mRNA
CTD PMID:27277809 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression EXP
ISO
citraconic acid results in increased expression of GCLM mRNA
citraconic acid results in increased expression of GCLM protein
CTD PMID:27277809 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gsr glutathione reductase increases expression ISO
EXP
citraconic acid results in increased expression of GSR protein
citraconic acid results in increased expression of GSR mRNA
CTD PMID:27277809 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
citraconic acid results in increased expression of HMOX1 mRNA
citraconic acid results in increased expression of HMOX1 mRNA; citraconic acid results in increased expression of HMOX1 protein
CTD PMID:27277809 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G mt-Cytb cytochrome b, mitochondrial increases expression
multiple interactions
EXP citraconic acid results in increased expression of CYTB mRNA
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA]
CTD PMID:27277809 NCBI chr MT:14,145...15,288
Ensembl chr MT:14,145...15,288
JBrowse link
G mt-Nd1 NADH dehydrogenase 1, mitochondrial increases expression
multiple interactions
EXP citraconic acid results in increased expression of ND1 mRNA
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA]
CTD PMID:27277809 NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707
JBrowse link
G mt-Nd5 NADH dehydrogenase 5, mitochondrial multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA] CTD PMID:27277809 NCBI chr MT:11,742...13,565
Ensembl chr MT:11,742...13,565
JBrowse link
G mt-Nd6 NADH dehydrogenase 6, mitochondrial multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA] CTD PMID:27277809 NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070
JBrowse link
G Mterf1a mitochondrial transcription termination factor 1a increases expression EXP citraconic acid results in increased expression of MTERF1A mRNA CTD PMID:27277809 NCBI chr 5:3,914,576...3,943,933
Ensembl chr 5:3,940,581...3,943,933
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization
multiple interactions
ISO
EXP
citraconic acid affects the localization of NFE2L2 protein
citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein]
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA]
CTD PMID:27277809 PMID:28289076 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO citraconic acid results in increased expression of NQO1 mRNA; citraconic acid results in increased expression of NQO1 protein CTD PMID:27277809 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Polrmt polymerase (RNA) mitochondrial (DNA directed) multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA] CTD PMID:27277809 NCBI chr10:79,571,951...79,582,436
Ensembl chr10:79,571,957...79,582,415
JBrowse link
D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation ISO
EXP
D-Aspartic Acid results in increased phosphorylation of AKT1 protein CTD PMID:26189884 PMID:31398714 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Ar androgen receptor affects expression
increases expression
ISO D-Aspartic Acid affects the expression of AR mRNA
D-Aspartic Acid results in increased expression of AR protein
CTD PMID:24439162 PMID:26044185 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Aurkb aurora kinase B increases expression EXP D-Aspartic Acid results in increased expression of AURKB protein CTD PMID:26189884 NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490
JBrowse link
G Casp3 caspase 3 multiple interactions ISO D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:30822420 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cln8 CLN8 transmembrane ER and ERGIC protein affects export
multiple interactions
EXP CLN8 protein affects the export of D-Aspartic Acid
CLN8 protein affects the reaction [[Ionomycin co-treated with Calcium] results in increased transport of D-Aspartic Acid]; CLN8 protein affects the reaction [[Potassium Chloride co-treated with Calcium] results in increased transport of D-Aspartic Acid]
CTD PMID:22302580 NCBI chr 8:14,931,335...14,951,720
Ensembl chr 8:14,931,335...14,951,720
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO D-Aspartic Acid results in increased expression of CYP11A1 mRNA CTD PMID:24713504 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
increases expression
ISO
EXP
D-Aspartic Acid results in decreased expression of CYP19A1 protein
D-Aspartic Acid results in increased expression of CYP19A1 mRNA; D-Aspartic Acid results in increased expression of CYP19A1 protein
CTD PMID:24439162 PMID:26044185 PMID:26189884 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Ddo D-aspartate oxidase increases degradation
affects abundance
increases metabolic processing
ISO
EXP
DDO protein results in increased degradation of D-Aspartic Acid
DDO protein affects the abundance of D-Aspartic Acid
DDO protein results in increased metabolism of D-Aspartic Acid
CTD PMID:16516413 PMID:16525061 PMID:16725213 PMID:18842900 PMID:26961959 More... NCBI chr10:40,505,933...40,557,847
Ensembl chr10:40,506,007...40,557,843
JBrowse link
G Esr1 estrogen receptor 1 (alpha) decreases expression
increases expression
ISO D-Aspartic Acid results in decreased expression of ESR1 protein
D-Aspartic Acid results in increased expression of ESR1 mRNA
CTD PMID:24439162 PMID:26044185 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) increases expression EXP D-Aspartic Acid results in increased expression of ESR2 protein CTD PMID:26189884 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) increases expression ISO D-Aspartic Acid results in increased expression of GRIN1 mRNA CTD PMID:24439162 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) increases expression ISO D-Aspartic Acid results in increased expression of GRIN2A mRNA CTD PMID:24439162 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424
JBrowse link
G Itpr3 inositol 1,4,5-triphosphate receptor 3 affects metabolic processing EXP ITPR3 mutant form affects the metabolism of D-Aspartic Acid CTD PMID:32853769 NCBI chr17:27,275,976...27,341,197
Ensembl chr17:27,276,278...27,341,197
JBrowse link
G Lhb luteinizing hormone beta increases expression ISO D-Aspartic Acid results in increased expression of LHB protein CTD PMID:24713504 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation ISO
EXP
D-Aspartic Acid results in increased phosphorylation of MAPK1 protein CTD PMID:24439162 PMID:26189884 PMID:31398714 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation EXP
ISO
D-Aspartic Acid results in increased phosphorylation of MAPK3 protein CTD PMID:24439162 PMID:26189884 PMID:31398714 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases cleavage
ISO D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased cleavage of MAPT protein] CTD PMID:30822420 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP D-Aspartic Acid results in increased expression of PCNA protein CTD PMID:26189884 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Prep prolyl endopeptidase increases expression ISO D-Aspartic Acid results in increased expression of PREP protein CTD PMID:31398714 NCBI chr10:44,943,312...45,038,847
Ensembl chr10:44,943,299...45,043,294
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO SOD1 protein affects the reaction [Glycine results in increased secretion of D-Aspartic Acid] CTD PMID:12684256 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases expression ISO D-Aspartic Acid results in increased expression of SRD5A1 mRNA CTD PMID:26044185 NCBI chr13:69,721,568...69,759,611
Ensembl chr13:69,721,568...69,759,561
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 increases expression ISO D-Aspartic Acid results in increased expression of SRD5A2 mRNA CTD PMID:26044185 NCBI chr17:74,321,886...74,354,855
Ensembl chr17:74,323,950...74,354,911
JBrowse link
G Srr serine racemase increases abundance
multiple interactions
ISO
EXP
SRR protein results in increased abundance of D-Aspartic Acid
[SRR protein results in increased metabolism of Aspartic Acid] which results in increased abundance of D-Aspartic Acid; Adenosine Triphosphate inhibits the reaction [Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]; Adenosine Triphosphate promotes the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Hydroxylamine inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Pyridoxal Phosphate inhibits the reaction [Hydroxylamine inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]
CTD PMID:27387750 NCBI chr11:74,794,853...74,818,427
Ensembl chr11:74,797,185...74,816,774
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO D-Aspartic Acid results in increased expression of STAR mRNA; D-Aspartic Acid results in increased expression of STAR protein CTD PMID:24713504 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
diethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO diethyl fumarate results in increased cleavage of CASP3 protein CTD PMID:21105742 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO diethyl fumarate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 increases cleavage ISO diethyl fumarate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463
JBrowse link
diethyl malate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle, aorta affects expression EXP diethyl malate affects the expression of ACTA2 mRNA CTD PMID:24814887 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 affects expression EXP diethyl malate affects the expression of ACTC1 mRNA CTD PMID:24814887 NCBI chr 2:113,877,763...113,883,356
Ensembl chr 2:113,877,763...113,884,029
JBrowse link
G Actn3 actinin alpha 3 affects expression EXP diethyl malate affects the expression of ACTN3 mRNA CTD PMID:24814887 NCBI chr19:4,911,244...4,927,937
Ensembl chr19:4,911,244...4,927,937
JBrowse link
G Adcy1 adenylate cyclase 1 affects expression EXP diethyl malate affects the expression of ADCY1 mRNA CTD PMID:24814887 NCBI chr11:7,013,433...7,128,506
Ensembl chr11:7,013,489...7,128,506
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) affects expression EXP diethyl malate affects the expression of ADH1 mRNA CTD PMID:24814887 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459
JBrowse link
G Agt angiotensinogen affects expression EXP diethyl malate affects the expression of AGT mRNA CTD PMID:24814887 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 affects expression EXP diethyl malate affects the expression of ALDH1A7 mRNA CTD PMID:24814887 NCBI chr19:20,670,318...20,704,920
Ensembl chr19:20,670,317...20,704,926
JBrowse link
G C3 complement component 3 affects expression EXP diethyl malate affects the expression of C3 mRNA CTD PMID:24814887 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G Cacnb2 calcium channel, voltage-dependent, beta 2 subunit affects expression EXP diethyl malate affects the expression of CACNB2 mRNA CTD PMID:24814887 NCBI chr 2:14,608,672...14,993,622
Ensembl chr 2:14,607,899...14,992,719
JBrowse link
G Cacnb4 calcium channel, voltage-dependent, beta 4 subunit affects expression EXP diethyl malate affects the expression of CACNB4 mRNA CTD PMID:24814887 NCBI chr 2:52,318,332...52,566,816
Ensembl chr 2:52,318,337...52,566,843
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions
affects expression
EXP S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA] CTD PMID:24814887 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224
JBrowse link
G Cbr2 carbonyl reductase 2 affects expression EXP diethyl malate affects the expression of CBR2 mRNA CTD PMID:24814887 NCBI chr11:120,620,311...120,622,851
Ensembl chr11:120,620,315...120,622,940
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 affects expression EXP diethyl malate affects the expression of CCL20 mRNA CTD PMID:24814887 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 affects expression EXP diethyl malate affects the expression of CCL6 mRNA CTD PMID:24814887 NCBI chr11:83,478,712...83,483,913
Ensembl chr11:83,478,708...83,483,913
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 affects expression EXP diethyl malate affects the expression of CCL7 mRNA CTD PMID:24814887 NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351
JBrowse link
G Ccl9 C-C motif chemokine ligand 9 affects expression EXP diethyl malate affects the expression of CCL9 mRNA CTD PMID:24814887 NCBI chr11:83,463,743...83,469,462
Ensembl chr11:83,463,745...83,469,462
JBrowse link
G Col11a1 collagen, type XI, alpha 1 affects expression EXP diethyl malate affects the expression of COL11A1 mRNA CTD PMID:24814887 NCBI chr 3:113,823,933...114,014,405
Ensembl chr 3:113,824,189...114,014,367
JBrowse link
G Col2a1 collagen, type II, alpha 1 affects expression EXP diethyl malate affects the expression of COL2A1 mRNA CTD PMID:24814887 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
JBrowse link
G Col3a1 collagen, type III, alpha 1 affects expression EXP diethyl malate affects the expression of COL3A1 mRNA CTD PMID:24814887 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866
JBrowse link
G Col6a1 collagen, type VI, alpha 1 affects expression EXP diethyl malate affects the expression of COL6A1 mRNA CTD PMID:24814887 NCBI chr10:76,544,626...76,561,869
Ensembl chr10:76,544,626...76,562,002
JBrowse link
G Comp cartilage oligomeric matrix protein affects expression EXP diethyl malate affects the expression of COMP mRNA CTD PMID:24814887 NCBI chr 8:70,826,186...70,834,721
Ensembl chr 8:70,826,208...70,834,716
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 affects expression
multiple interactions
EXP diethyl malate affects the expression of CXCL12 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA]
CTD PMID:24814887 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 affects expression EXP diethyl malate affects the expression of CXCL5 mRNA CTD PMID:24814887 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression EXP diethyl malate affects the expression of CXCL1 mRNA CTD PMID:24814887 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 affects expression EXP diethyl malate affects the expression of CYP2J9 mRNA CTD PMID:24814887 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815
JBrowse link
G Dapk2 death-associated protein kinase 2 affects expression EXP diethyl malate affects the expression of DAPK2 mRNA CTD PMID:24814887 NCBI chr 9:66,065,364...66,179,524
Ensembl chr 9:66,065,505...66,179,524
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 affects expression EXP diethyl malate affects the expression of DHRS3 mRNA CTD PMID:24814887 NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779
JBrowse link
G Dhx58 DExH-box helicase 58 affects expression EXP diethyl malate affects the expression of DHX58 mRNA CTD PMID:24814887 NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097
JBrowse link
G Edar ectodysplasin-A receptor affects expression EXP diethyl malate affects the expression of EDAR mRNA CTD PMID:24814887 NCBI chr10:58,436,602...58,511,518
Ensembl chr10:58,436,611...58,511,476
JBrowse link
G Ednra endothelin receptor type A affects expression EXP diethyl malate affects the expression of EDNRA mRNA CTD PMID:24814887 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093
JBrowse link
G Epas1 endothelial PAS domain protein 1 affects expression EXP diethyl malate affects the expression of EPAS1 mRNA CTD PMID:24814887 NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838
JBrowse link
G Epha7 Eph receptor A7 affects expression EXP diethyl malate affects the expression of EPHA7 mRNA CTD PMID:24814887 NCBI chr 4:28,811,840...28,969,391
Ensembl chr 4:28,813,131...28,967,499
JBrowse link
G Ephb2 Eph receptor B2 affects expression EXP diethyl malate affects the expression of EPHB2 mRNA CTD PMID:24814887 NCBI chr 4:136,374,850...136,563,637
Ensembl chr 4:136,374,850...136,563,299
JBrowse link
G Ephb6 Eph receptor B6 affects expression EXP diethyl malate affects the expression of EPHB6 mRNA CTD PMID:24814887 NCBI chr 6:41,581,940...41,597,445
Ensembl chr 6:41,582,416...41,597,443
JBrowse link
G Fgf10 fibroblast growth factor 10 affects expression EXP diethyl malate affects the expression of FGF10 mRNA CTD PMID:24814887 NCBI chr13:118,851,199...118,928,651
Ensembl chr13:118,806,327...118,928,651
JBrowse link
G Fgf18 fibroblast growth factor 18 multiple interactions
affects expression
EXP S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA] CTD PMID:24814887 NCBI chr11:33,066,970...33,097,400
Ensembl chr11:33,067,430...33,097,400
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 affects expression EXP diethyl malate affects the expression of FGFR2 mRNA CTD PMID:24814887 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079
JBrowse link
G Fst follistatin affects expression EXP diethyl malate affects the expression of FST mRNA CTD PMID:24814887 NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487
JBrowse link
G Fzd2 frizzled class receptor 2 affects expression EXP diethyl malate affects the expression of FZD2 mRNA CTD PMID:24814887 NCBI chr11:102,495,257...102,498,884
Ensembl chr11:102,495,222...102,498,884
JBrowse link
G Fzd7 frizzled class receptor 7 affects expression EXP diethyl malate affects the expression of FZD7 mRNA CTD PMID:24814887 NCBI chr 1:59,521,306...59,526,114
Ensembl chr 1:59,521,583...59,526,114
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects expression EXP diethyl malate affects the expression of GCLC mRNA CTD PMID:24814887 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions
affects expression
EXP S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA] CTD PMID:24814887 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Ggt6 gamma-glutamyltransferase 6 affects expression EXP diethyl malate affects the expression of GGT6 mRNA CTD PMID:24814887 NCBI chr11:72,326,067...72,329,392
Ensembl chr11:72,326,352...72,329,226
JBrowse link
G Gli2 GLI-Kruppel family member GLI2 affects expression EXP diethyl malate affects the expression of GLI2 mRNA CTD PMID:24814887 NCBI chr 1:118,761,791...118,987,578
Ensembl chr 1:118,761,862...118,981,349
JBrowse link
G Gnao1 guanine nucleotide binding protein, alpha O affects expression EXP diethyl malate affects the expression of GNAO1 mRNA CTD PMID:24814887 NCBI chr 8:94,537,213...94,696,016
Ensembl chr 8:94,536,594...94,696,016
JBrowse link
G Gng7 guanine nucleotide binding protein (G protein), gamma 7 affects expression EXP diethyl malate affects the expression of GNG7 mRNA CTD PMID:24814887 NCBI chr10:80,784,463...80,850,742
Ensembl chr10:80,784,458...80,850,779
JBrowse link
G Gsr glutathione reductase affects expression EXP diethyl malate affects the expression of GSR mRNA CTD PMID:24814887 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gss glutathione synthetase multiple interactions
affects expression
EXP S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA] CTD PMID:24814887 NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 affects expression
multiple interactions
EXP diethyl malate affects the expression of GSTA1 mRNA; diethyl malate affects the expression of GSTA3 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA]; S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA3 mRNA]
CTD PMID:24814887 NCBI chr 1:21,310,837...21,335,885
Ensembl chr 1:21,310,813...21,335,885
JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 affects expression EXP diethyl malate affects the expression of GUCY1A1 mRNA CTD PMID:24814887 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096
JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 affects expression EXP diethyl malate affects the expression of GUCY1B1 mRNA CTD PMID:24814887 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996
JBrowse link
G H2-DMb1 histocompatibility 2, class II, locus Mb1 affects expression EXP diethyl malate affects the expression of H2-DMB1 mRNA CTD PMID:24814887 NCBI chr17:34,372,165...34,379,203
Ensembl chr17:34,372,046...34,379,204
JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 affects expression EXP diethyl malate affects the expression of H2-M3 mRNA CTD PMID:24814887 NCBI chr17:37,581,094...37,585,380
Ensembl chr17:37,581,111...37,585,375
JBrowse link
G Hck hemopoietic cell kinase affects expression EXP diethyl malate affects the expression of HCK mRNA CTD PMID:24814887 NCBI chr 2:152,950,388...152,993,361
Ensembl chr 2:152,950,388...152,993,361
JBrowse link
G Hgf hepatocyte growth factor affects expression EXP diethyl malate affects the expression of HGF mRNA CTD PMID:24814887 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression EXP diethyl malate affects the expression of IGF1 mRNA CTD PMID:24814887 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Il15 interleukin 15 affects expression EXP diethyl malate affects the expression of IL15 mRNA CTD PMID:24814887 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851
JBrowse link
G Il18 interleukin 18 affects expression EXP diethyl malate affects the expression of IL18 mRNA CTD PMID:24814887 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Irag1 inositol 1,4,5-triphosphate receptor associated 1 affects expression EXP diethyl malate affects the expression of IRAG1 mRNA CTD PMID:24814887 NCBI chr 7:110,467,464...110,582,116
Ensembl chr 7:110,467,473...110,581,668
JBrowse link
G Irf7 interferon regulatory factor 7 affects expression EXP diethyl malate affects the expression of IRF7 mRNA CTD PMID:24814887 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier affects expression EXP diethyl malate affects the expression of ISG15 mRNA CTD PMID:24814887 NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253
JBrowse link
G Itga11 integrin alpha 11 affects expression EXP diethyl malate affects the expression of ITGA11 mRNA CTD PMID:24814887 NCBI chr 9:62,585,137...62,691,618
Ensembl chr 9:62,585,108...62,691,264
JBrowse link
G Itga3 integrin alpha 3 affects expression EXP diethyl malate affects the expression of ITGA3 mRNA CTD PMID:24814887 NCBI chr11:94,935,301...94,967,637
Ensembl chr11:94,935,300...94,967,627
JBrowse link
G Kcnmb4 potassium large conductance calcium-activated channel, subfamily M, beta member 4 affects expression EXP diethyl malate affects the expression of KCNMB4 mRNA CTD PMID:24814887 NCBI chr10:116,251,951...116,309,787
Ensembl chr10:116,253,766...116,309,783
JBrowse link
G Lama1 laminin, alpha 1 affects expression EXP diethyl malate affects the expression of LAMA1 mRNA CTD PMID:24814887 NCBI chr17:68,004,129...68,129,640
Ensembl chr17:68,004,254...68,129,642
JBrowse link
G Lama4 laminin, alpha 4 affects expression EXP diethyl malate affects the expression of LAMA4 mRNA CTD PMID:24814887 NCBI chr10:38,841,511...38,986,184
Ensembl chr10:38,841,511...38,986,184
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 affects phosphorylation
multiple interactions
EXP diethyl malate affects the phosphorylation of MAPK1 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein]
CTD PMID:24814887 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 affects phosphorylation
multiple interactions
EXP diethyl malate affects the phosphorylation of MAPK3 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein]
CTD PMID:24814887 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Myl9 myosin, light polypeptide 9, regulatory affects expression EXP diethyl malate affects the expression of MYL9 mRNA CTD PMID:24814887 NCBI chr 2:156,617,373...156,623,578
Ensembl chr 2:156,617,340...156,623,578
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 affects expression EXP diethyl malate affects the expression of ODC1 mRNA CTD PMID:24814887 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide affects expression
multiple interactions
EXP diethyl malate affects the expression of PDGFB mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]
CTD PMID:24814887 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178
JBrowse link
G Pdgfd platelet-derived growth factor, D polypeptide affects expression EXP diethyl malate affects the expression of PDGFD mRNA CTD PMID:24814887 NCBI chr 9:6,168,377...6,534,284
Ensembl chr 9:6,168,584...6,378,850
JBrowse link
G Pf4 platelet factor 4 affects expression EXP diethyl malate affects the expression of PF4 mRNA CTD PMID:24814887 NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242
JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 affects expression EXP diethyl malate affects the expression of PIK3IP1 mRNA CTD PMID:24814887 NCBI chr11:3,280,731...3,292,971
Ensembl chr11:3,280,401...3,292,971
JBrowse link
G Plxnc1 plexin C1 affects expression EXP diethyl malate affects the expression of PLXNC1 mRNA CTD PMID:24814887 NCBI chr10:94,626,728...94,780,875
Ensembl chr10:94,626,728...94,780,697
JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I affects expression EXP diethyl malate affects the expression of PRKG1 mRNA CTD PMID:24814887 NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433
JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase affects expression EXP diethyl malate affects the expression of PTGIS mRNA CTD PMID:24814887 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524
JBrowse link
G Ramp2 receptor (calcitonin) activity modifying protein 2 affects expression EXP diethyl malate affects the expression of RAMP2 mRNA CTD PMID:24814887 NCBI chr11:101,137,160...101,139,076
Ensembl chr11:101,136,854...101,150,372
JBrowse link
G Rgs3 regulator of G-protein signaling 3 affects expression EXP diethyl malate affects the expression of RGS3 mRNA CTD PMID:24814887 NCBI chr 4:62,478,079...62,621,256
Ensembl chr 4:62,478,084...62,622,238
JBrowse link
G Rigi RNA sensor RIG-I affects expression EXP diethyl malate affects the expression of RIGI mRNA CTD PMID:24814887 NCBI chr 4:40,203,775...40,239,843
Ensembl chr 4:40,203,773...40,239,828
JBrowse link
G Runx1t1 RUNX1 translocation partner 1 affects expression EXP diethyl malate affects the expression of RUNX1T1 mRNA CTD PMID:24814887 NCBI chr 4:13,742,628...13,895,056
Ensembl chr 4:13,743,436...13,893,649
JBrowse link
G Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B affects expression EXP diethyl malate affects the expression of SEMA3B mRNA CTD PMID:24814887 NCBI chr 9:107,474,868...107,486,440
Ensembl chr 9:107,474,873...107,486,428
JBrowse link
G Sema4g sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G affects expression EXP diethyl malate affects the expression of SEMA4G mRNA CTD PMID:24814887 NCBI chr19:44,976,838...44,991,836
Ensembl chr19:44,977,540...44,991,836
JBrowse link
G Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A affects expression EXP diethyl malate affects the expression of SEMA5A mRNA CTD PMID:24814887 NCBI chr15:32,244,959...32,696,487
Ensembl chr15:32,244,956...32,696,487
JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects expression EXP diethyl malate affects the expression of STAT1 mRNA CTD PMID:24814887 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression
multiple interactions
EXP diethyl malate affects the expression of TGFB2 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]
CTD PMID:24814887 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186
JBrowse link
G Thbs1 thrombospondin 1 affects expression EXP diethyl malate affects the expression of THBS1 mRNA CTD PMID:24814887 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614
JBrowse link
G Thbs2 thrombospondin 2 affects expression EXP diethyl malate affects the expression of THBS2 mRNA CTD PMID:24814887 NCBI chr17:14,885,762...14,914,524
Ensembl chr17:14,885,762...14,914,497
JBrowse link
G Tnc tenascin C affects expression EXP diethyl malate affects the expression of TNC mRNA CTD PMID:24814887 NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) affects expression EXP diethyl malate affects the expression of TNFRSF11B mRNA CTD PMID:24814887 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880
JBrowse link
G Tnnt1 troponin T1, skeletal, slow affects expression EXP diethyl malate affects the expression of TNNT1 mRNA CTD PMID:24814887 NCBI chr 7:4,507,568...4,518,974
Ensembl chr 7:4,507,569...4,519,381
JBrowse link
G Tslp thymic stromal lymphopoietin affects expression EXP diethyl malate affects the expression of TSLP mRNA CTD PMID:24814887 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850
JBrowse link
diethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family member 2 increases expression EXP diethyl maleate results in increased expression of ABCC2 mRNA CTD PMID:25270620 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abhd4 abhydrolase domain containing 4 increases expression EXP diethyl maleate results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr14:54,491,586...54,506,626
Ensembl chr14:54,491,645...54,508,094
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha decreases expression EXP diethyl maleate results in decreased expression of ACACA mRNA CTD PMID:25270620 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions ISO diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]] CTD PMID:17134953 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
JBrowse link
G Acy3 aminoacylase 3 decreases expression ISO diethyl maleate results in decreased expression of ACY3 mRNA CTD PMID:21161181 NCBI chr19:4,036,570...4,040,007
Ensembl chr19:4,036,570...4,040,007
JBrowse link
G Adm adrenomedullin increases expression ISO diethyl maleate results in increased expression of ADM mRNA CTD PMID:33545341 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027
JBrowse link
G Adora3 adenosine A3 receptor decreases expression ISO diethyl maleate results in decreased expression of ADORA3 mRNA CTD PMID:21161181 NCBI chr 3:105,811,737...105,816,244
Ensembl chr 3:105,778,174...105,816,242
JBrowse link
G Aen apoptosis enhancing nuclease increases expression ISO diethyl maleate results in increased expression of AEN mRNA CTD PMID:33545341 NCBI chr 7:78,545,675...78,560,957
Ensembl chr 7:78,545,602...78,560,957
JBrowse link
G Afp alpha fetoprotein increases expression EXP diethyl maleate results in increased expression of AFP mRNA CTD PMID:25270620 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
JBrowse link
G Ahcyl1 S-adenosylhomocysteine hydrolase-like 1 increases expression EXP diethyl maleate results in increased expression of AHCYL1 mRNA CTD PMID:25270620 NCBI chr 3:107,570,436...107,603,876
Ensembl chr 3:107,570,434...107,603,876
JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 increases expression ISO diethyl maleate results in increased expression of AKR1A1 protein CTD PMID:21161181 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 increases expression ISO diethyl maleate results in increased expression of AKR1B10 mRNA CTD PMID:33545341 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
JBrowse link
G Akr1c19 aldo-keto reductase family 1, member C19 increases expression EXP diethyl maleate results in increased expression of AKR1C19 mRNA CTD PMID:25270620 NCBI chr13:4,283,499...4,298,360
Ensembl chr13:4,278,699...4,302,842
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases expression ISO diethyl maleate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 affects reduction EXP diethyl maleate affects the reduction of ALDH1A1 protein CTD PMID:19843705 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression ISO diethyl maleate results in decreased expression of ALDH1B1 mRNA CTD PMID:21161181 NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial decreases reduction
increases expression
decreases expression
EXP
ISO
diethyl maleate results in decreased reduction of ALDH2 protein
diethyl maleate results in increased expression of ALDH2 protein
diethyl maleate results in decreased expression of ALDH2 protein
CTD PMID:19843705 PMID:21161181 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
JBrowse link
G Aldob aldolase B, fructose-bisphosphate decreases expression ISO diethyl maleate results in decreased expression of ALDOB protein CTD PMID:21161181 NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO diethyl maleate results in decreased expression of AMIGO2 mRNA CTD PMID:21161181 NCBI chr15:97,141,955...97,145,168
Ensembl chr15:97,142,006...97,145,168
JBrowse link
G Angptl2 angiopoietin-like 2 decreases expression ISO diethyl maleate results in decreased expression of ANGPTL2 mRNA CTD PMID:21161181 NCBI chr 2:33,105,963...33,137,737
Ensembl chr 2:33,106,081...33,137,729
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO diethyl maleate results in increased expression of ANGPTL4 mRNA CTD PMID:33545341 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804
JBrowse link
G Ankrd46 ankyrin repeat domain 46 decreases expression ISO diethyl maleate results in decreased expression of ANKRD46 mRNA CTD PMID:21161181 NCBI chr15:36,477,814...36,496,937
Ensembl chr15:36,477,814...36,496,966
JBrowse link
G Anln anillin, actin binding protein increases expression ISO diethyl maleate results in increased expression of ANLN mRNA CTD PMID:21161181 NCBI chr 9:22,243,305...22,302,132
Ensembl chr 9:22,243,308...22,300,484
JBrowse link
G Anxa1 annexin A1 affects expression ISO diethyl maleate affects the expression of ANXA1 mRNA CTD PMID:34480604 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
JBrowse link
G Anxa3 annexin A3 decreases expression ISO diethyl maleate results in decreased expression of ANXA3 mRNA CTD PMID:21161181 NCBI chr 5:96,941,257...96,993,825
Ensembl chr 5:96,941,198...96,993,825
JBrowse link
G Ap3m2 adaptor-related protein complex 3, mu 2 subunit decreases expression ISO diethyl maleate results in decreased expression of AP3M2 mRNA CTD PMID:21161181 NCBI chr 8:23,277,370...23,297,308
Ensembl chr 8:23,277,370...23,295,638
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO diethyl maleate results in increased expression of APAF1 mRNA CTD PMID:11875189 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632
JBrowse link
G Aplp1 amyloid beta precursor like protein 1 decreases expression EXP diethyl maleate results in decreased expression of APLP1 mRNA CTD PMID:25270620 NCBI chr 7:30,134,405...30,144,960
Ensembl chr 7:30,134,407...30,144,960
JBrowse link
G Apol9a apolipoprotein L 9a decreases expression ISO diethyl maleate results in decreased expression of APOL9A mRNA CTD PMID:21161181 NCBI chr15:77,287,989...77,295,280
Ensembl chr15:77,287,989...77,295,335
JBrowse link
G Arhgap9 Rho GTPase activating protein 9 increases expression ISO diethyl maleate results in increased expression of ARHGAP9 mRNA CTD PMID:33545341 NCBI chr10:127,157,829...127,165,816
Ensembl chr10:127,157,833...127,165,812
JBrowse link
G Arrdc2 arrestin domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of ARRDC2 mRNA CTD PMID:21161181 NCBI chr 8:71,287,773...71,293,173
Ensembl chr 8:71,287,773...71,292,364
JBrowse link
G Arrdc4 arrestin domain containing 4 decreases expression EXP diethyl maleate results in decreased expression of ARRDC4 mRNA CTD PMID:25270620 NCBI chr 7:68,386,742...68,398,986
Ensembl chr 7:68,386,743...68,398,989
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone increases expression ISO diethyl maleate results in increased expression of ASF1B mRNA CTD PMID:21161181 NCBI chr 8:84,682,323...84,696,824
Ensembl chr 8:84,682,136...84,696,826
JBrowse link
G Asxl1 ASXL transcriptional regulator 1 decreases expression EXP diethyl maleate results in decreased expression of ASXL1 mRNA CTD PMID:25270620 NCBI chr 2:153,187,750...153,245,927
Ensembl chr 2:153,187,749...153,245,927
JBrowse link
G Atm ataxia telangiectasia mutated increases expression ISO diethyl maleate results in increased expression of ATM mRNA CTD PMID:11875189 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression ISO diethyl maleate results in increased expression of ATP5F1B protein CTD PMID:21161181 NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260
JBrowse link
G Aurka aurora kinase A increases expression
decreases expression
ISO
EXP
diethyl maleate results in increased expression of AURKA mRNA
diethyl maleate results in decreased expression of AURKA mRNA
CTD PMID:21161181 PMID:25270620 NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO diethyl maleate results in increased expression of BBC3 mRNA CTD PMID:33545341 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases expression
EXP
ISO
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA
diethyl maleate results in increased expression of BCL2 mRNA
CTD PMID:22564015 PMID:33545341 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b decreases expression ISO diethyl maleate results in decreased expression of BCL2A1 mRNA CTD PMID:21161181 NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880
JBrowse link
G Bcl3 B cell leukemia/lymphoma 3 decreases expression EXP diethyl maleate results in decreased expression of BCL3 mRNA CTD PMID:25270620 NCBI chr 7:19,542,387...19,556,691
Ensembl chr 7:19,542,387...19,556,695
JBrowse link
G Bcl6b B cell CLL/lymphoma 6, member B decreases expression ISO diethyl maleate results in decreased expression of BCL6B mRNA CTD PMID:21161181 NCBI chr11:70,114,953...70,120,624
Ensembl chr11:70,114,954...70,120,624
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 decreases expression ISO diethyl maleate results in decreased expression of BHLHE41 mRNA CTD PMID:21161181 NCBI chr 6:145,803,969...145,811,146
Ensembl chr 6:145,803,969...145,811,284
JBrowse link
G Bhmt betaine-homocysteine methyltransferase decreases expression ISO diethyl maleate results in decreased expression of BHMT mRNA CTD PMID:21161181 NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions EXP diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA] CTD PMID:12774022 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
JBrowse link
G Blvrb biliverdin reductase B increases expression EXP diethyl maleate results in increased expression of BLVRB mRNA CTD PMID:25270620 PMID:34626751 NCBI chr 7:27,147,403...27,165,406
Ensembl chr 7:27,147,403...27,165,569
JBrowse link
G Bmf BCL2 modifying factor decreases expression ISO diethyl maleate results in decreased expression of BMF mRNA CTD PMID:21161181 NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168
JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 increases expression ISO diethyl maleate results in increased expression of BRIP1 mRNA CTD PMID:21161181 NCBI chr11:85,948,957...86,092,041
Ensembl chr11:85,948,964...86,092,019
JBrowse link
G Btbd2 BTB domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of BTBD2 mRNA CTD PMID:21161181 NCBI chr10:80,478,457...80,492,328
Ensembl chr10:80,478,451...80,492,328
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression
decreases expression
multiple interactions
EXP diethyl maleate results in increased expression of BTG2 mRNA
diethyl maleate results in decreased expression of BTG2 mRNA
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
CTD PMID:22003191 PMID:25270620 PMID:34626751 NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858
JBrowse link
G C6 complement component 6 decreases expression ISO diethyl maleate results in decreased expression of C6 mRNA CTD PMID:21161181 NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449
JBrowse link
G Casp2 caspase 2 increases expression ISO diethyl maleate results in increased expression of CASP2 mRNA CTD PMID:11875189 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO diethyl maleate results in increased expression of CASP3 mRNA
diethyl maleate results in increased cleavage of CASP3 protein
CTD PMID:11875189 PMID:21105742 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 increases expression ISO diethyl maleate results in increased expression of CASP9 mRNA CTD PMID:11875189 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase decreases expression ISO diethyl maleate results in decreased expression of CAT protein CTD PMID:21161181 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression EXP diethyl maleate results in increased expression of CBR1 mRNA CTD PMID:25270620 NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression
multiple interactions
ISO
EXP
diethyl maleate results in increased expression of CBR3 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA]
CTD PMID:20806931 PMID:25270620 NCBI chr16:93,480,107...93,487,879
Ensembl chr16:93,480,103...93,487,878
JBrowse link
G Cbx4 chromobox 4 increases expression ISO diethyl maleate results in increased expression of CBX4 mRNA CTD PMID:33545341 NCBI chr11:118,968,399...118,977,067
Ensembl chr11:118,968,399...118,977,047
JBrowse link
G Ccdc50 coiled-coil domain containing 50 decreases expression EXP diethyl maleate results in decreased expression of CCDC50 mRNA CTD PMID:25270620 NCBI chr16:27,205,815...27,270,968
Ensembl chr16:27,207,619...27,270,968
JBrowse link
G Ccna1 cyclin A1 decreases expression ISO diethyl maleate results in decreased expression of CCNA1 mRNA CTD PMID:11875189 NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922
JBrowse link
G Ccna2 cyclin A2 increases expression ISO diethyl maleate results in increased expression of CCNA2 mRNA CTD PMID:21161181 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression
ISO
EXP
diethyl maleate results in decreased expression of CCND1 mRNA
diethyl maleate results in increased expression of CCND1 mRNA
CTD PMID:11875189 PMID:21161181 PMID:25270620 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccne2 cyclin E2 increases expression ISO diethyl maleate results in increased expression of CCNE2 mRNA CTD PMID:21161181 NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Ccnk cyclin K decreases expression ISO diethyl maleate results in decreased expression of CCNK mRNA CTD PMID:11875189 NCBI chr12:108,145,543...108,170,252
Ensembl chr12:108,145,838...108,169,618
JBrowse link
G Cd80 CD80 antigen multiple interactions
increases expression
ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
diethyl maleate results in increased expression of CD80 protein
CTD PMID:31958493 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
JBrowse link
G Cd86 CD86 antigen multiple interactions
increases expression
ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein] CTD PMID:24136171 PMID:31958493 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO diethyl maleate results in increased expression of CDC25A mRNA CTD PMID:21161181 NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression ISO diethyl maleate results in increased expression of CDCA2 mRNA CTD PMID:21161181 NCBI chr14:67,910,629...67,953,290
Ensembl chr14:67,913,780...67,953,290
JBrowse link
G Cdca3 cell division cycle associated 3 increases expression ISO diethyl maleate results in increased expression of CDCA3 mRNA CTD PMID:21161181 NCBI chr 6:124,806,533...124,810,664
Ensembl chr 6:124,806,510...124,810,664
JBrowse link
G Cdca8 cell division cycle associated 8 increases expression ISO diethyl maleate results in increased expression of CDCA8 mRNA CTD PMID:21161181 NCBI chr 4:124,812,258...124,830,710
Ensembl chr 4:124,812,258...124,833,104
JBrowse link
G Cdh11 cadherin 11 decreases expression ISO diethyl maleate results in decreased expression of CDH11 mRNA CTD PMID:21161181 NCBI chr 8:103,358,727...103,512,125
Ensembl chr 8:103,358,727...103,512,274
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
ISO diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]
CTD PMID:11875189 PMID:27982581 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cds2 CDP-diacylglycerol synthase 2 increases expression EXP diethyl maleate results in increased expression of CDS2 mRNA CTD PMID:25270620 NCBI chr 2:132,105,068...132,153,970
Ensembl chr 2:132,105,068...132,153,970
JBrowse link
G Ces1d carboxylesterase 1D increases reduction
decreases expression
EXP
ISO
diethyl maleate results in increased reduction of CES1D protein
diethyl maleate results in decreased expression of CES1D protein
CTD PMID:19843705 PMID:21161181 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
JBrowse link
G Ces2a carboxylesterase 2A increases reduction EXP diethyl maleate results in increased reduction of CES2A protein CTD PMID:19843705 NCBI chr 8:105,460,635...105,468,266
Ensembl chr 8:105,460,635...105,468,266
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO diethyl maleate results in decreased expression of CFLAR mRNA CTD PMID:21161181 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 increases expression ISO diethyl maleate results in increased expression of CHRNA4 mRNA CTD PMID:33545341 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339
JBrowse link
G Cidec cell death-inducing DFFA-like effector c decreases expression ISO diethyl maleate results in decreased expression of CIDEC mRNA CTD PMID:21161181 NCBI chr 6:113,401,595...113,412,721
Ensembl chr 6:113,401,595...113,412,721
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO diethyl maleate results in decreased expression of CITED2 mRNA CTD PMID:21161181 NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422
JBrowse link
G Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 decreases expression ISO diethyl maleate results in decreased expression of CITED4 mRNA CTD PMID:21161181 NCBI chr 4:120,523,760...120,525,017
Ensembl chr 4:120,523,769...120,525,017
JBrowse link
G Ckb creatine kinase, brain decreases reduction EXP diethyl maleate results in decreased reduction of CKB protein CTD PMID:19843705 NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO diethyl maleate results in increased expression of CKS2 mRNA CTD PMID:33545341 NCBI chr13:51,799,268...51,804,698
Ensembl chr13:51,799,268...51,804,696
JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO diethyl maleate results in increased expression of CLK1 mRNA CTD PMID:33545341 NCBI chr 1:58,451,147...58,463,247
Ensembl chr 1:58,449,348...58,463,225
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 decreases expression ISO diethyl maleate results in decreased expression of CMPK2 mRNA CTD PMID:21161181 NCBI chr12:26,519,121...26,529,836
Ensembl chr12:26,519,203...26,529,836
JBrowse link
G Cntn1 contactin 1 increases expression ISO diethyl maleate results in increased expression of CNTN1 mRNA CTD PMID:33545341 NCBI chr15:91,949,034...92,239,834
Ensembl chr15:91,949,046...92,239,848
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression ISO diethyl maleate results in decreased expression of COL1A1 mRNA CTD PMID:21161181 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Col3a1 collagen, type III, alpha 1 decreases expression EXP diethyl maleate results in decreased expression of COL3A1 mRNA CTD PMID:25270620 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866
JBrowse link
G Commd3 COMM domain containing 3 increases expression EXP diethyl maleate results in increased expression of COMMD3 mRNA CTD PMID:25270620 NCBI chr 2:18,677,246...18,681,042
Ensembl chr 2:18,677,234...18,681,042
JBrowse link
G Comt catechol-O-methyltransferase decreases expression ISO diethyl maleate results in decreased expression of COMT mRNA CTD PMID:21161181 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
G Cp ceruloplasmin decreases expression EXP diethyl maleate results in decreased expression of CP mRNA CTD PMID:25270620 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309
JBrowse link
G Cpsf4l cleavage and polyadenylation specific factor 4-like increases expression ISO diethyl maleate results in increased expression of CPSF4L mRNA CTD PMID:33545341 NCBI chr11:113,588,997...113,601,125
Ensembl chr11:113,588,998...113,600,843
JBrowse link
G Crym crystallin, mu decreases expression ISO diethyl maleate results in decreased expression of CRYM mRNA CTD PMID:21161181 NCBI chr 7:119,785,603...119,801,212
Ensembl chr 7:119,785,603...119,801,334
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression ISO diethyl maleate results in decreased expression of CSRP1 mRNA CTD PMID:21161181 NCBI chr 1:135,614,650...135,679,970
Ensembl chr 1:135,647,799...135,679,970
JBrowse link
G Csrp3 cysteine and glycine-rich protein 3 decreases reduction EXP diethyl maleate results in decreased reduction of CSRP3 protein CTD PMID:19843705 NCBI chr 7:48,480,146...48,497,799
Ensembl chr 7:48,480,146...48,497,781
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression ISO diethyl maleate results in decreased expression of CXCL10 mRNA CTD PMID:21161181 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO diethyl maleate results in decreased expression of CXCL12 mRNA CTD PMID:21161181 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression
multiple interactions
increases secretion
increases stability
ISO diethyl maleate results in increased expression of CXCL8 mRNA; diethyl maleate results in increased expression of CXCL8 protein
bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CXCL8 protein]
diethyl maleate results in increased secretion of CXCL8 protein
diethyl maleate results in increased stability of CXCL8 mRNA
CTD PMID:20491607 PMID:20541004 PMID:21920952 PMID:21969073 PMID:24136171 More... NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression ISO diethyl maleate results in decreased expression of CXCL9 mRNA CTD PMID:21161181 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
JBrowse link
G Cyb5a cytochrome b5 type A (microsomal) increases expression EXP diethyl maleate results in increased expression of CYB5A mRNA CTD PMID:25270620 NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression ISO diethyl maleate results in decreased expression of CYP26B1 mRNA CTD PMID:21161181 NCBI chr 6:84,548,396...84,570,890
Ensembl chr 6:84,548,396...84,570,890
JBrowse link
G D17H6S56E-5 DNA segment, Chr 17, human D6S56E 5 decreases expression EXP diethyl maleate results in decreased expression of D17H6S56E-5 mRNA CTD PMID:25270620 NCBI chr17:35,215,654...35,219,722
Ensembl chr17:35,215,654...35,219,393
JBrowse link
G Dbp D site albumin promoter binding protein decreases expression ISO diethyl maleate results in decreased expression of DBP mRNA CTD PMID:21161181 NCBI chr 7:45,354,658...45,359,579
Ensembl chr 7:45,354,512...45,359,627
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO diethyl maleate results in increased expression of DDIT3 mRNA; diethyl maleate results in increased expression of DDIT3 protein CTD PMID:33545341 PMID:35724838 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO diethyl maleate results in increased expression of DDIT4 mRNA CTD PMID:33545341 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression EXP diethyl maleate results in increased expression of DDIT4L mRNA CTD PMID:25270620 NCBI chr 3:137,329,433...137,334,093
Ensembl chr 3:137,327,373...137,334,094
JBrowse link
G Ddx60 DExD/H box helicase 60 decreases expression ISO diethyl maleate results in decreased expression of DDX60 mRNA CTD PMID:21161181 NCBI chr 8:62,381,155...62,491,278
Ensembl chr 8:62,381,121...62,491,278
JBrowse link
G Dhx58 DExH-box helicase 58 decreases expression ISO diethyl maleate results in decreased expression of DHX58 mRNA CTD PMID:21161181 NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO diethyl maleate results in increased expression of DNAJB1 mRNA CTD PMID:33545341 PMID:34480604 NCBI chr 8:84,334,804...84,339,282
Ensembl chr 8:84,334,822...84,339,282
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO diethyl maleate results in increased expression of DNAJB4 mRNA CTD PMID:33545341 NCBI chr 3:151,887,217...151,915,720
Ensembl chr 3:151,884,148...151,915,939
JBrowse link
G Dnmbp dynamin binding protein decreases expression ISO diethyl maleate results in decreased expression of DNMBP mRNA CTD PMID:21161181 NCBI chr19:43,835,259...43,930,930
Ensembl chr19:43,835,260...43,928,630
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 decreases reduction EXP diethyl maleate results in decreased reduction of DPYSL2 protein CTD PMID:19843705 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,106,137
JBrowse link
G Dtx3l deltex 3-like, E3 ubiquitin ligase decreases expression ISO diethyl maleate results in decreased expression of DTX3L mRNA CTD PMID:21161181 NCBI chr16:35,746,885...35,759,397
Ensembl chr16:35,746,881...35,759,521
JBrowse link
G Dus3l dihydrouridine synthase 3 like decreases expression EXP diethyl maleate results in decreased expression of DUS3L mRNA CTD PMID:25270620 NCBI chr17:57,069,224...57,077,093
Ensembl chr17:57,071,757...57,077,093
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO diethyl maleate results in increased expression of DUSP6 mRNA CTD PMID:33545341 NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression ISO diethyl maleate results in decreased expression of EEF2K mRNA CTD PMID:21161181 NCBI chr 7:120,442,080...120,506,441
Ensembl chr 7:120,442,054...120,506,673
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression ISO diethyl maleate results in increased expression of EGLN3 mRNA CTD PMID:34480604 NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression ISO diethyl maleate results in decreased expression of EIF2AK2 mRNA CTD PMID:21161181 NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 increases expression EXP diethyl maleate results in increased expression of ENTPD5 mRNA CTD PMID:25270620 NCBI chr12:84,420,649...84,455,803
Ensembl chr12:84,420,631...84,455,803
JBrowse link
G Eras ES cell-expressed Ras decreases expression EXP diethyl maleate results in decreased expression of ERAS mRNA CTD PMID:25270620 NCBI chr  X:7,790,515...7,794,846
Ensembl chr  X:7,790,515...7,794,846
JBrowse link
G Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 like increases expression ISO diethyl maleate results in increased expression of ERCC6L mRNA CTD PMID:21161181 NCBI chr  X:101,186,426...101,200,697
Ensembl chr  X:101,185,322...101,200,697
JBrowse link
G Exo1 exonuclease 1 increases expression ISO diethyl maleate results in increased expression of EXO1 mRNA CTD PMID:21161181 NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055
JBrowse link
G Fabp1 fatty acid binding protein 1, liver increases expression ISO diethyl maleate results in increased expression of FABP1 protein CTD PMID:21161181 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
JBrowse link
G Fabp7 fatty acid binding protein 7, brain decreases expression ISO diethyl maleate results in decreased expression of FABP7 mRNA CTD PMID:21161181 NCBI chr10:57,661,019...57,664,546
Ensembl chr10:57,660,977...57,664,546
JBrowse link
G Fah fumarylacetoacetate hydrolase affects expression ISO diethyl maleate affects the expression of FAH mRNA CTD PMID:34480604 NCBI chr 7:84,234,367...84,255,150
Ensembl chr 7:84,234,367...84,255,930
JBrowse link
G Fam83d family with sequence similarity 83, member D increases expression ISO diethyl maleate results in increased expression of FAM83D mRNA CTD PMID:33545341 NCBI chr 2:158,610,011...158,628,557
Ensembl chr 2:158,610,013...158,628,557
JBrowse link
G Fasn fatty acid synthase decreases expression ISO diethyl maleate results in decreased expression of FASN mRNA CTD PMID:21161181 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO diethyl maleate results in decreased expression of FBN1 mRNA CTD PMID:21161181 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913
JBrowse link
G Fbp1 fructose bisphosphatase 1 decreases expression ISO diethyl maleate results in decreased expression of FBP1 protein CTD PMID:21161181 NCBI chr13:63,012,567...63,036,112
Ensembl chr13:63,012,567...63,036,096
JBrowse link
G Fgf17 fibroblast growth factor 17 decreases expression EXP diethyl maleate results in decreased expression of FGF17 mRNA CTD PMID:25270620 NCBI chr14:70,873,643...70,880,064
Ensembl chr14:70,873,643...70,879,708
JBrowse link
G Fgg fibrinogen gamma chain decreases expression EXP diethyl maleate results in decreased expression of FGG mRNA CTD PMID:25270620 NCBI chr 3:82,915,031...82,922,363
Ensembl chr 3:82,915,031...82,922,356
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases expression ISO diethyl maleate results in decreased expression of FGR mRNA CTD PMID:21161181 NCBI chr 4:132,701,406...132,729,204
Ensembl chr 4:132,701,406...132,729,221
JBrowse link
G Fndc3b fibronectin type III domain containing 3B decreases expression EXP diethyl maleate results in decreased expression of FNDC3B mRNA CTD PMID:25270620 NCBI chr 3:27,470,284...27,765,469
Ensembl chr 3:27,470,311...27,765,456
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression EXP
ISO
diethyl maleate results in increased expression of FOS mRNA CTD PMID:10915739 PMID:33545341 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein] CTD PMID:30261343 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Foxo3 forkhead box O3 increases expression ISO diethyl maleate results in increased expression of FOXO3 mRNA CTD PMID:33545341 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
JBrowse link
G Fstl3 follistatin-like 3 increases expression ISO diethyl maleate results in increased expression of FSTL3 mRNA CTD PMID:33545341 NCBI chr10:79,613,108...79,618,464
Ensembl chr10:79,613,106...79,618,464
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO
EXP
diethyl maleate results in decreased expression of G6PC1 mRNA CTD PMID:25270620 PMID:30261343 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases activity
increases expression
ISO diethyl maleate results in increased activity of G6PD protein
diethyl maleate results in increased expression of G6PD mRNA
CTD PMID:3099627 PMID:30261343 PMID:33545341 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800
JBrowse link
G Gab1 growth factor receptor bound protein 2-associated protein 1 decreases expression EXP diethyl maleate results in decreased expression of GAB1 mRNA CTD PMID:25270620 NCBI chr 8:81,491,060...81,607,151
Ensembl chr 8:81,491,067...81,607,148
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO diethyl maleate results in increased expression of GADD45A mRNA CTD PMID:33545341 PMID:34480604 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma increases expression ISO diethyl maleate results in increased expression of GADD45G mRNA CTD PMID:33545341 NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases reduction EXP diethyl maleate results in increased reduction of GAPDH protein CTD PMID:19843705 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
JBrowse link
G Gba2 glucosidase beta 2 decreases expression EXP diethyl maleate results in decreased expression of GBA2 mRNA CTD PMID:25270620 NCBI chr 4:43,566,928...43,578,893
Ensembl chr 4:43,566,928...43,578,873
JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression ISO diethyl maleate results in decreased expression of GBP2 mRNA CTD PMID:21161181 NCBI chr 3:142,326,424...142,343,769
Ensembl chr 3:142,326,363...142,343,769
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
EXP
ISO
diethyl maleate results in increased activity of GCLC protein
diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein
CTD PMID:10915739 PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 More... NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO
EXP
diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein CTD PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 More... NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO diethyl maleate results in increased expression of GCNT3 mRNA CTD PMID:33545341 NCBI chr 9:69,938,777...69,947,172
Ensembl chr 9:69,938,778...69,945,370
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO diethyl maleate results in increased expression of GDF15 mRNA CTD PMID:33545341 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Gdf9 growth differentiation factor 9 increases expression ISO diethyl maleate results in increased expression of GDF9 mRNA CTD PMID:33545341 NCBI chr11:53,321,773...53,328,731
Ensembl chr11:53,321,850...53,328,731
JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 increases expression ISO diethyl maleate results in increased expression of GFOD1 mRNA CTD PMID:33545341 NCBI chr13:43,348,716...43,457,648
Ensembl chr13:43,348,721...43,457,648
JBrowse link
G Glul glutamate-ammonia ligase decreases expression EXP diethyl maleate results in decreased expression of GLUL mRNA CTD PMID:25270620 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469
JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial decreases expression ISO diethyl maleate results in decreased expression of GOT2 protein CTD PMID:21161181 NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175
JBrowse link
G Gpihbp1 GPI-anchored HDL-binding protein 1 decreases expression EXP diethyl maleate results in decreased expression of GPIHBP1 mRNA CTD PMID:25270620 NCBI chr15:75,468,479...75,470,062
Ensembl chr15:75,468,477...75,471,330
JBrowse link
G Gpx2 glutathione peroxidase 2 affects expression ISO diethyl maleate affects the expression of GPX2 mRNA CTD PMID:34480604 NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273
JBrowse link
G Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) decreases expression ISO diethyl maleate results in decreased expression of GRIA3 mRNA CTD PMID:21161181 NCBI chr  X:40,489,351...40,767,478
Ensembl chr  X:40,489,731...40,767,478
JBrowse link
G Gsn gelsolin decreases reduction EXP diethyl maleate results in decreased reduction of GSN protein CTD PMID:19843705 NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904
JBrowse link
G Gsr glutathione reductase increases expression EXP diethyl maleate results in increased expression of GSR mRNA CTD PMID:25270620 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gss glutathione synthetase increases expression ISO diethyl maleate results in increased expression of GSS mRNA CTD PMID:10978506 NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) increases expression ISO diethyl maleate results in increased expression of GSTA5 protein CTD PMID:9794803 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP diethyl maleate results in increased expression of GSTA2 mRNA CTD PMID:25270620 NCBI chr 9:78,197,210...78,212,807
Ensembl chr 9:78,197,205...78,212,807
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions EXP [diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA CTD PMID:22564015 NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 decreases expression ISO diethyl maleate results in decreased expression of GSTM1 protein CTD PMID:21161181 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression EXP diethyl maleate results in increased expression of GSTO1 mRNA CTD PMID:25270620 NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases expression ISO diethyl maleate results in increased expression of GSTP1 protein CTD PMID:9794803 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 increases expression ISO diethyl maleate results in increased expression of GSTT1 protein CTD PMID:9794803 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418
JBrowse link
G Gtse1 G two S phase expressed protein 1 increases expression ISO diethyl maleate results in increased expression of GTSE1 mRNA CTD PMID:21161181 NCBI chr15:85,743,928...85,760,774
Ensembl chr15:85,743,946...85,760,774
JBrowse link
G H2az2 H2A.Z histone variant 2 increases expression ISO diethyl maleate results in increased expression of H2AZ2 mRNA CTD PMID:33545341 NCBI chr11:6,377,226...6,394,511
Ensembl chr11:6,377,229...6,394,443
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) increases expression EXP diethyl maleate results in increased expression of H6PD mRNA CTD PMID:25270620 NCBI chr 4:150,063,931...150,093,480
Ensembl chr 4:150,063,932...150,093,480
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO diethyl maleate results in increased expression of HAMP mRNA CTD PMID:33545341 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
JBrowse link
G Helb helicase (DNA) B decreases expression EXP diethyl maleate results in decreased expression of HELB mRNA CTD PMID:25270620 NCBI chr10:119,919,513...119,948,917
Ensembl chr10:119,919,513...119,948,892
JBrowse link
G Hes6 hairy and enhancer of split 6 decreases expression ISO diethyl maleate results in decreased expression of HES6 mRNA CTD PMID:21161181 NCBI chr 1:91,339,204...91,342,901
Ensembl chr 1:91,339,205...91,341,760
JBrowse link
G Hjurp Holliday junction recognition protein increases expression ISO diethyl maleate results in increased expression of HJURP mRNA CTD PMID:21161181 NCBI chr 1:88,186,578...88,205,366
Ensembl chr 1:88,190,193...88,205,355
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO
EXP
diethyl maleate results in increased expression of HMOX1 mRNA; diethyl maleate results in increased expression of HMOX1 protein CTD PMID:20491607 PMID:25270620 PMID:30261343 PMID:33545341 PMID:34480604 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases reduction EXP diethyl maleate results in decreased reduction of HNRNPH1 protein CTD PMID:19843705 NCBI chr11:50,266,084...50,277,355
Ensembl chr11:50,267,817...50,277,355
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 increases expression ISO diethyl maleate results in increased expression of HSD17B10 mRNA CTD PMID:33545341 NCBI chr  X:150,784,892...150,787,438
Ensembl chr  X:150,784,841...150,787,438
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression ISO diethyl maleate results in decreased expression of HSD17B2 mRNA CTD PMID:21161181 NCBI chr 8:118,427,752...118,485,767
Ensembl chr 8:118,428,643...118,485,766
JBrowse link
G Hspa1b heat shock protein 1B increases expression ISO diethyl maleate results in increased expression of HSPA1B mRNA CTD PMID:33545341 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
JBrowse link
G Hspa1l heat shock protein 1-like increases expression ISO diethyl maleate results in increased expression of HSPA1L mRNA CTD PMID:33545341 NCBI chr17:35,191,679...35,198,204
Ensembl chr17:35,191,679...35,198,261
JBrowse link
G Hspa5 heat shock protein 5 decreases reduction EXP diethyl maleate results in decreased reduction of HSPA5 protein CTD PMID:19843705 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Hspa8 heat shock protein 8 increases reduction EXP diethyl maleate results in increased reduction of HSPA8 protein CTD PMID:19843705 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression EXP diethyl maleate results in increased expression of HTATIP2 mRNA CTD PMID:25270620 NCBI chr 7:49,408,761...49,423,748
Ensembl chr 7:49,408,863...49,423,723
JBrowse link
G Hycc2 hyccin PI4KA lipid kinase complex subunit 2 decreases expression ISO diethyl maleate results in decreased expression of HYCC2 mRNA CTD PMID:21161181 NCBI chr 1:58,561,965...58,625,492
Ensembl chr 1:58,561,965...58,625,482
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP
ISO
diethyl maleate results in decreased expression of ICAM1 mRNA
diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
CTD PMID:25270620 PMID:35724838 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression EXP diethyl maleate results in decreased expression of ID3 mRNA CTD PMID:25270620 NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066
JBrowse link
G Id4 inhibitor of DNA binding 4 decreases expression EXP diethyl maleate results in decreased expression of ID4 mRNA CTD PMID:25270620 NCBI chr13:48,414,592...48,419,504
Ensembl chr13:48,414,704...48,419,502
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO diethyl maleate results in decreased expression of IFIT3 mRNA CTD PMID:21161181 NCBI chr19:34,560,519...34,566,382
Ensembl chr19:34,560,931...34,566,131
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO diethyl maleate results in increased expression of IFRD1 mRNA CTD PMID:33545341 NCBI chr12:40,253,128...40,273,184
Ensembl chr12:40,251,566...40,298,503
JBrowse link
G Ikbke inhibitor of kappaB kinase epsilon decreases expression EXP diethyl maleate results in decreased expression of IKBKE mRNA CTD PMID:25270620 NCBI chr 1:131,182,337...131,207,339
Ensembl chr 1:131,182,080...131,207,344
JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma increases expression EXP diethyl maleate results in increased expression of IKBKG mRNA CTD PMID:25270620 NCBI chr  X:73,436,883...73,498,013
Ensembl chr  X:73,436,896...73,497,460
JBrowse link
G Il10 interleukin 10 increases secretion ISO diethyl maleate results in increased secretion of IL10 protein CTD PMID:31958493 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il18 interleukin 18 increases expression ISO diethyl maleate results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO diethyl maleate inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [IL1B protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein] CTD PMID:35724838 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il1r1 interleukin 1 receptor, type I affects expression ISO diethyl maleate affects the expression of IL1R1 mRNA CTD PMID:34480604 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Inhbb inhibin beta-B decreases expression EXP diethyl maleate results in decreased expression of INHBB mRNA CTD PMID:25270620 NCBI chr 1:119,343,193...119,349,978
Ensembl chr 1:119,343,195...119,349,978
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression ISO diethyl maleate results in decreased expression of INMT mRNA CTD PMID:21161181 NCBI chr 6:55,147,612...55,151,975
Ensembl chr 6:55,147,611...55,152,028
JBrowse link
G Ins2 insulin II multiple interactions ISO diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein] CTD PMID:30261343 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Ints7 integrator complex subunit 7 decreases expression EXP diethyl maleate results in decreased expression of INTS7 mRNA CTD PMID:25270620 NCBI chr 1:191,307,652...191,355,802
Ensembl chr 1:191,307,748...191,355,800
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO diethyl maleate results in decreased expression of IRF7 mRNA CTD PMID:21161181 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394
JBrowse link
G Irf9 interferon regulatory factor 9 decreases expression ISO diethyl maleate results in decreased expression of IRF9 mRNA CTD PMID:21161181 NCBI chr14:55,841,442...55,847,487
Ensembl chr14:55,841,028...55,847,487
JBrowse link
G Irgm1 immunity-related GTPase family M member 1 decreases expression ISO diethyl maleate results in decreased expression of IRGM mRNA CTD PMID:21161181 NCBI chr11:48,756,072...48,762,247
Ensembl chr11:48,752,795...48,762,510
JBrowse link
G Itgal integrin alpha L decreases expression ISO diethyl maleate results in decreased expression of ITGAL mRNA CTD PMID:21161181 NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 decreases expression EXP diethyl maleate results in decreased expression of ITIH3 mRNA CTD PMID:25270620 NCBI chr14:30,630,529...30,645,748
Ensembl chr14:30,630,529...30,645,717
JBrowse link
G Itih4 inter alpha-trypsin inhibitor, heavy chain 4 decreases expression EXP diethyl maleate results in decreased expression of ITIH4 mRNA CTD PMID:25270620 NCBI chr14:30,608,433...30,623,943
Ensembl chr14:30,608,433...30,624,310
JBrowse link
G Jam3 junction adhesion molecule 3 decreases expression ISO diethyl maleate results in decreased expression of JAM3 mRNA CTD PMID:21161181 NCBI chr 9:27,008,680...27,066,739
Ensembl chr 9:27,008,680...27,066,717
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
increases phosphorylation
EXP
ISO
pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
diethyl maleate results in increased expression of JUN protein modified form
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of JUN protein modified form]
diethyl maleate results in increased expression of JUN mRNA
CTD PMID:10915739 PMID:12774022 PMID:30261343 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kcne3 potassium voltage-gated channel, Isk-related subfamily, gene 3 decreases expression EXP diethyl maleate results in decreased expression of KCNE3 mRNA CTD PMID:25270620 NCBI chr 7:99,825,714...99,834,076
Ensembl chr 7:99,825,709...99,834,076
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 increases expression ISO diethyl maleate results in increased expression of KEAP1 mRNA; diethyl maleate results in increased expression of KEAP1 protein CTD PMID:27358234 PMID:33545341 PMID:34480604 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
JBrowse link
G Khdrbs3 KH domain containing, RNA binding, signal transduction associated 3 increases expression ISO diethyl maleate results in increased expression of KHDRBS3 mRNA CTD PMID:33545341 NCBI chr15:68,800,155...68,973,064
Ensembl chr15:68,800,269...68,973,060
JBrowse link
G Kifc1 kinesin family member C1 increases expression ISO diethyl maleate results in increased expression of KIFC1 mRNA CTD PMID:21161181 NCBI chr17:34,094,640...34,109,607
Ensembl chr17:34,094,633...34,109,635
JBrowse link
G Klf10 Kruppel-like transcription factor 10 decreases expression ISO
EXP
diethyl maleate results in decreased expression of KLF10 mRNA CTD PMID:21161181 PMID:25270620 NCBI chr15:38,291,702...38,300,950
Ensembl chr15:38,291,707...38,300,950
JBrowse link
G Krt75 keratin 75 increases reduction EXP diethyl maleate results in increased reduction of KRT75 protein CTD PMID:19843705 NCBI chr15:101,471,778...101,482,339
Ensembl chr15:101,471,780...101,482,339
JBrowse link
G Lama1 laminin, alpha 1 decreases expression EXP diethyl maleate results in decreased expression of LAMA1 mRNA CTD PMID:25270620 NCBI chr17:68,004,129...68,129,640
Ensembl chr17:68,004,254...68,129,642
JBrowse link
G Lancl2 LanC (bacterial lantibiotic synthetase component C)-like 2 decreases expression EXP diethyl maleate results in decreased expression of LANCL2 mRNA CTD PMID:25270620 NCBI chr 6:57,679,440...57,716,434
Ensembl chr 6:57,679,525...57,716,424
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO diethyl maleate results in decreased expression of LDLR mRNA CTD PMID:21161181 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
JBrowse link
G Lepr leptin receptor decreases expression ISO diethyl maleate results in decreased expression of LEPR mRNA CTD PMID:21161181 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein decreases expression ISO diethyl maleate results in decreased expression of LGALS3BP mRNA CTD PMID:21161181 NCBI chr11:118,283,573...118,292,787
Ensembl chr11:118,283,577...118,292,918
JBrowse link
G Lmnb1 lamin B1 increases expression ISO diethyl maleate results in increased expression of LMNB1 mRNA CTD PMID:21161181 NCBI chr18:56,840,885...56,886,496
Ensembl chr18:56,840,885...56,886,496
JBrowse link
G Lmo7 LIM domain only 7 decreases expression ISO diethyl maleate results in decreased expression of LMO7 mRNA CTD PMID:21161181 NCBI chr14:101,967,353...102,172,144
Ensembl chr14:101,967,393...102,172,146
JBrowse link
G Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 decreases expression ISO diethyl maleate results in decreased expression of LRIG3 mRNA CTD PMID:21161181 NCBI chr10:125,802,088...125,851,228
Ensembl chr10:125,802,037...125,851,228
JBrowse link
G Lrrn4 leucine rich repeat neuronal 4 increases expression ISO diethyl maleate results in increased expression of LRRN4 mRNA CTD PMID:21161181 NCBI chr 2:132,710,436...132,735,930
Ensembl chr 2:132,710,225...132,722,811
JBrowse link
G Lrtm2 leucine-rich repeats and transmembrane domains 2 decreases expression ISO diethyl maleate results in decreased expression of LRTM2 mRNA CTD PMID:21161181 NCBI chr 6:119,292,094...119,315,009
Ensembl chr 6:119,292,094...119,307,727
JBrowse link
G Ltc4s leukotriene C4 synthase decreases expression ISO diethyl maleate results in decreased expression of LTC4S mRNA CTD PMID:21161181 NCBI chr11:50,127,288...50,129,378
Ensembl chr11:50,127,288...50,129,443
JBrowse link
G Lum lumican decreases expression ISO diethyl maleate results in decreased expression of LUM mRNA CTD PMID:21161181 NCBI chr10:97,401,363...97,408,565
Ensembl chr10:97,400,990...97,408,565
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO diethyl maleate results in increased expression of MAFF mRNA CTD PMID:20491607 PMID:33545341 NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) increases expression ISO diethyl maleate results in increased expression of MAFG mRNA CTD PMID:33545341 PMID:34480604 NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426
JBrowse link
G Maoa monoamine oxidase A increases expression EXP diethyl maleate results in increased expression of MAOA mRNA CTD PMID:25270620 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Mapk1ip1l mitogen-activated protein kinase 1 interacting protein 1-like increases expression ISO diethyl maleate results in increased expression of MAPK1IP1L mRNA CTD PMID:33545341 NCBI chr14:47,535,731...47,560,663
Ensembl chr14:47,535,723...47,560,661
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression
multiple interactions
ISO diethyl maleate results in increased expression of MAPK8 protein modified form
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK8 protein modified form]
CTD PMID:30261343 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression
multiple interactions
ISO diethyl maleate results in increased expression of MAPK9 protein modified form
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK9 protein modified form]
CTD PMID:30261343 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Marveld1 MARVEL (membrane-associating) domain containing 1 decreases expression ISO diethyl maleate results in decreased expression of MARVELD1 mRNA CTD PMID:21161181 NCBI chr19:42,135,879...42,140,137
Ensembl chr19:42,135,839...42,140,142
JBrowse link
G Mboat7 membrane bound O-acyltransferase domain containing 7 increases expression ISO diethyl maleate results in increased expression of MBOAT7 mRNA CTD PMID:33545341 NCBI chr 7:3,680,788...3,696,188
Ensembl chr 7:3,680,788...3,696,522
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor increases expression ISO diethyl maleate results in increased expression of MCM10 mRNA CTD PMID:21161181 NCBI chr 2:4,995,535...5,017,602
Ensembl chr 2:4,994,525...5,017,602
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO diethyl maleate results in increased expression of MCM4 mRNA CTD PMID:21161181 NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression EXP diethyl maleate results in increased expression of ME1 mRNA CTD PMID:25270620 NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006
JBrowse link
G Mfap4 microfibrillar-associated protein 4 decreases expression ISO diethyl maleate results in decreased expression of MFAP4 mRNA CTD PMID:21161181 NCBI chr11:61,376,257...61,379,536
Ensembl chr11:61,376,257...61,379,726
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO diethyl maleate results in decreased activity of MGMT protein CTD PMID:16950796 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 increases expression ISO diethyl maleate results in increased expression of MKI67 mRNA CTD PMID:21161181 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 decreases expression ISO diethyl maleate results in decreased expression of MKNK2 mRNA CTD PMID:21161181 NCBI chr10:80,501,152...80,512,264
Ensembl chr10:80,501,161...80,513,946
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression EXP diethyl maleate results in increased expression of MMP12 mRNA CTD PMID:10216232 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) increases expression ISO diethyl maleate results in increased expression of MMP1 mRNA CTD PMID:33545341 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO diethyl maleate results in decreased expression of MMP2 mRNA CTD PMID:21161181 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO diethyl maleate results in increased expression of MMP3 mRNA CTD PMID:33545341 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mpzl1 myelin protein zero-like 1 decreases expression ISO diethyl maleate results in decreased expression of MPZL1 mRNA CTD PMID:34480604 NCBI chr 1:165,419,745...165,462,144
Ensembl chr 1:165,419,809...165,462,107
JBrowse link
G Msn moesin increases reduction EXP diethyl maleate results in increased reduction of MSN protein CTD PMID:19843705 NCBI chr  X:95,139,651...95,212,159
Ensembl chr  X:95,139,648...95,212,158
JBrowse link
G Mt2 metallothionein 2 increases expression ISO diethyl maleate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
JBrowse link
G Mx1 MX dynamin-like GTPase 1 decreases expression ISO diethyl maleate results in decreased expression of MX1 mRNA CTD PMID:21161181 NCBI chr16:97,248,235...97,264,106
Ensembl chr16:97,248,235...97,264,107
JBrowse link
G Mybl2 myeloblastosis oncogene-like 2 increases expression ISO diethyl maleate results in increased expression of MYBL2 mRNA CTD PMID:21161181 NCBI chr 2:162,896,246...162,926,608
Ensembl chr 2:162,896,607...162,926,608
JBrowse link
G Mycn v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived decreases expression EXP diethyl maleate results in decreased expression of MYCN mRNA CTD PMID:25270620 NCBI chr12:12,986,094...12,991,837
Ensembl chr12:12,986,094...12,991,915
JBrowse link
G Nat8 N-acetyltransferase 8 (GCN5-related) decreases expression ISO diethyl maleate results in decreased expression of NAT8 mRNA CTD PMID:21161181 NCBI chr 6:85,807,369...85,813,839
Ensembl chr 6:85,807,370...85,809,064
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression ISO diethyl maleate results in increased expression of NCAPH mRNA CTD PMID:21161181 NCBI chr 2:126,945,729...126,975,857
Ensembl chr 2:126,945,729...126,975,874
JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 increases expression ISO diethyl maleate results in increased expression of NDRG1 mRNA CTD PMID:33545341 NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization
increases activity
increases expression
multiple interactions
decreases response to substance
EXP
ISO
diethyl maleate affects the localization of NFE2L2 protein
diethyl maleate results in increased activity of NFE2L2 protein
diethyl maleate results in increased expression of NFE2L2 protein
[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; diethyl maleate binds to and results in increased activity of NFE2L2 protein; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; diethyl maleate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]
NFE2L2 results in decreased susceptibility to diethyl maleate
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
CTD PMID:12235164 PMID:20806931 PMID:21465251 PMID:22003191 PMID:25762726 More... NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP
ISO
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]
diethyl maleate inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of NFKBIA protein]
CTD PMID:12774022 PMID:35724838 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 decreases expression ISO diethyl maleate results in decreased expression of NHERF1 mRNA CTD PMID:21161181 NCBI chr11:115,054,138...115,072,009
Ensembl chr11:115,054,167...115,072,007
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]
Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
CTD PMID:7532384 PMID:9918918 PMID:12774022 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Notch1 notch 1 increases expression ISO diethyl maleate results in increased expression of NOTCH1 mRNA CTD PMID:33545341 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO
EXP
diethyl maleate results in increased expression of NQO1 mRNA CTD PMID:20491607 PMID:25270620 PMID:33545341 PMID:34480604 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO diethyl maleate results in decreased expression of NR0B2 mRNA CTD PMID:21161181 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO diethyl maleate results in decreased expression of NR1D1 mRNA CTD PMID:21161181 NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159
JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO diethyl maleate results in decreased expression of NREP mRNA CTD PMID:21161181 NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082
JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor decreases expression EXP diethyl maleate results in decreased expression of NSMF mRNA CTD PMID:25270620 NCBI chr 2:24,944,370...24,952,893
Ensembl chr 2:24,944,367...24,952,893
JBrowse link
G Ntf3 neurotrophin 3 decreases expression ISO diethyl maleate results in decreased expression of NTF3 mRNA CTD PMID:21161181 NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873
JBrowse link
G Nup153 nucleoporin 153 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; diethyl maleate results in increased phosphorylation of and results in increased O-linked glycosylation of NUP153 protein CTD PMID:20041180 NCBI chr13:46,833,369...46,890,682
Ensembl chr13:46,833,381...46,881,416
JBrowse link
G Nup88 nucleoporin 88 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]; diethyl maleate results in increased phosphorylation of and results in increased glycosylation of NUP88 protein CTD PMID:20041180 NCBI chr11:70,833,884...70,860,799
Ensembl chr11:70,833,884...70,860,799
JBrowse link
G Oaf out at first homolog decreases expression ISO diethyl maleate results in decreased expression of OAF mRNA CTD PMID:21161181 NCBI chr 9:43,132,575...43,151,113
Ensembl chr 9:43,132,532...43,151,208
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 multiple interactions EXP [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA CTD PMID:22564015 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression ISO diethyl maleate results in increased expression of ORC1 mRNA CTD PMID:21161181 NCBI chr 4:108,436,651...108,472,030
Ensembl chr 4:108,436,620...108,472,030
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO diethyl maleate results in increased expression of OSGIN1 mRNA CTD PMID:33545341 NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 decreases expression ISO diethyl maleate results in decreased expression of P2RX7 mRNA CTD PMID:21161181 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO diethyl maleate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 decreases expression ISO diethyl maleate results in decreased expression of PBLD protein CTD PMID:21161181 NCBI chr10:62,896,404...62,913,743
Ensembl chr10:62,895,941...62,913,741
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO diethyl maleate results in decreased expression of PCNA mRNA CTD PMID:11875189 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression ISO diethyl maleate results in decreased expression of PDLIM2 mRNA CTD PMID:21161181 NCBI chr14:70,401,667...70,415,140
Ensembl chr14:70,401,667...70,415,130
JBrowse link
G Pdrg1 p53 and DNA damage regulated 1 increases expression EXP diethyl maleate results in increased expression of PDRG1 mRNA CTD PMID:25270620 NCBI chr 2:152,850,810...152,857,939
Ensembl chr 2:152,850,810...152,857,347
JBrowse link
G Per2 period circadian clock 2 decreases expression ISO diethyl maleate results in decreased expression of PER2 mRNA CTD PMID:21161181 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046
JBrowse link
G Per3 period circadian clock 3 decreases expression ISO diethyl maleate results in decreased expression of PER3 mRNA CTD PMID:21161181 NCBI chr 4:151,081,475...151,129,167
Ensembl chr 4:151,088,109...151,129,122
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity ISO diethyl maleate results in increased activity of PGD protein CTD PMID:3099627 NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression EXP diethyl maleate results in increased expression of PGRMC1 mRNA CTD PMID:25270620 NCBI chr  X:35,861,846...35,869,732
Ensembl chr  X:35,861,859...35,869,732
JBrowse link
G Pir pirin increases expression EXP diethyl maleate results in increased expression of PIR mRNA CTD PMID:25270620 NCBI chr  X:163,052,427...163,156,009
Ensembl chr  X:163,052,367...163,156,007
JBrowse link
G Pklr pyruvate kinase liver and red blood cell decreases expression ISO diethyl maleate results in decreased expression of PKLR mRNA CTD PMID:21161181 NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091
JBrowse link
G Plat plasminogen activator, tissue increases expression
decreases expression
ISO
EXP
diethyl maleate results in increased expression of PLAT mRNA
diethyl maleate results in decreased expression of PLAT mRNA
CTD PMID:21161181 PMID:25270620 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
JBrowse link
G Plek pleckstrin decreases expression ISO diethyl maleate results in decreased expression of PLEK mRNA CTD PMID:21161181 NCBI chr11:16,921,206...16,958,718
Ensembl chr11:16,921,206...17,002,381
JBrowse link
G Plekhm1 pleckstrin homology domain containing, family M (with RUN domain) member 1 increases expression ISO diethyl maleate results in increased expression of PLEKHM1 mRNA CTD PMID:33545341 NCBI chr11:103,255,101...103,303,531
Ensembl chr11:103,255,101...103,303,513
JBrowse link
G Plin2 perilipin 2 increases expression ISO diethyl maleate results in increased expression of PLIN2 mRNA CTD PMID:33545341 NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297
JBrowse link
G Plk1 polo like kinase 1 increases expression ISO diethyl maleate results in increased expression of PLK1 mRNA CTD PMID:33545341 NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096
JBrowse link
G Plk3 polo like kinase 3 increases expression ISO diethyl maleate results in increased expression of PLK3 mRNA CTD PMID:33545341 NCBI chr 4:116,985,852...116,991,244
Ensembl chr 4:116,985,852...116,991,160
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 increases expression ISO diethyl maleate results in increased expression of POU5F1 mRNA CTD PMID:33545341 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases activity
ISO diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol inhibits the reaction [diethyl maleate results in decreased activity of PPARA protein]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate results in decreased activity of PPARA protein] CTD PMID:17134953 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta decreases expression ISO diethyl maleate results in decreased expression of PPARGC1B mRNA CTD PMID:21161181 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502
JBrowse link
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B decreases expression ISO diethyl maleate results in decreased expression of PPP1R3B mRNA CTD PMID:21161181 NCBI chr 8:35,842,847...35,855,293
Ensembl chr 8:35,842,893...35,855,293
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C decreases expression ISO diethyl maleate results in decreased expression of PPP1R3C mRNA CTD PMID:21161181 NCBI chr19:36,709,131...36,714,004
Ensembl chr19:36,709,131...36,714,053
JBrowse link
G Prdm14 PR domain containing 14 decreases expression EXP diethyl maleate results in decreased expression of PRDM14 mRNA CTD PMID:25270620 NCBI chr 1:13,183,649...13,197,467
Ensembl chr 1:13,183,681...13,197,387
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP
ISO
diethyl maleate results in increased expression of PRDX1 mRNA CTD PMID:9506838 NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019
JBrowse link
G Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit decreases expression EXP diethyl maleate results in decreased expression of PRKAB1 mRNA CTD PMID:25270620 NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567
JBrowse link
G Prkag2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit increases expression ISO diethyl maleate results in increased expression of PRKAG2 mRNA CTD PMID:33545341 NCBI chr 5:25,067,733...25,311,576
Ensembl chr 5:25,067,742...25,305,640
JBrowse link
G Prkcb protein kinase C, beta affects expression ISO diethyl maleate affects the expression of PRKCB protein CTD PMID:31958493 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCD protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCD protein CTD PMID:11118818 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCE protein CTD PMID:11118818 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
JBrowse link
G Prss8 serine protease 8 (prostasin) decreases expression ISO diethyl maleate results in decreased expression of PRSS8 mRNA CTD PMID:21161181 NCBI chr 7:127,524,889...127,529,266
Ensembl chr 7:127,524,888...127,529,276
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression EXP diethyl maleate results in increased expression of PTGR1 mRNA CTD PMID:25270620 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G Ptpn14 protein tyrosine phosphatase, non-receptor type 14 increases expression EXP diethyl maleate results in increased expression of PTPN14 mRNA CTD PMID:25270620 NCBI chr 1:189,460,417...189,608,892
Ensembl chr 1:189,460,465...189,608,892
JBrowse link
G Pus1 pseudouridine synthase 1 decreases expression EXP diethyl maleate results in decreased expression of PUS1 mRNA CTD PMID:25270620 NCBI chr 5:110,921,533...110,928,523
Ensembl chr 5:110,921,533...110,928,525
JBrowse link
G Pxn paxillin increases expression ISO diethyl maleate results in increased expression of PXN mRNA CTD PMID:33545341 NCBI chr 5:115,630,035...115,694,046
Ensembl chr 5:115,644,735...115,694,046
JBrowse link
G Rab27a RAB27A, member RAS oncogene family decreases expression ISO diethyl maleate results in decreased expression of RAB27A mRNA CTD PMID:21161181 NCBI chr 9:72,952,092...73,004,905
Ensembl chr 9:72,952,136...73,004,911
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [IL1B protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of RELA protein]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; RELA protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein] CTD PMID:20116392 PMID:35724838 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rho rhodopsin increases expression ISO diethyl maleate results in increased expression of RHO mRNA CTD PMID:33545341 NCBI chr 6:115,903,741...115,916,999
Ensembl chr 6:115,908,709...115,916,997
JBrowse link
G Rnf114 ring finger protein 114 decreases expression EXP diethyl maleate results in decreased expression of RNF114 mRNA CTD PMID:25270620 NCBI chr 2:167,334,565...167,358,093
Ensembl chr 2:167,334,565...167,358,093
JBrowse link
G Rnf14 ring finger protein 14 increases expression EXP diethyl maleate results in increased expression of RNF14 mRNA CTD PMID:25270620 NCBI chr18:38,410,513...38,450,905
Ensembl chr18:38,417,590...38,450,902
JBrowse link
G Rrm2 ribonucleotide reductase M2 increases expression ISO diethyl maleate results in increased expression of RRM2 mRNA CTD PMID:21161181 PMID:33545341 NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of RSAD2 mRNA CTD PMID:21161181 NCBI chr12:26,492,742...26,506,451
Ensembl chr12:26,492,745...26,506,451
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) decreases expression ISO diethyl maleate results in decreased expression of S100A9 mRNA CTD PMID:21161181 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
JBrowse link
G Sash3 SAM and SH3 domain containing 3 decreases expression ISO diethyl maleate results in decreased expression of SASH3 mRNA CTD PMID:21161181 NCBI chr  X:47,235,313...47,250,442
Ensembl chr  X:47,235,313...47,250,442
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression ISO diethyl maleate results in decreased expression of SCARB1 mRNA CTD PMID:34480604 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 decreases expression ISO diethyl maleate results in decreased expression of SCD1 mRNA CTD PMID:21161181 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
JBrowse link
G Sds serine dehydratase decreases expression ISO diethyl maleate results in decreased expression of SDS mRNA CTD PMID:21161181 NCBI chr 5:120,614,612...120,621,997
Ensembl chr 5:120,614,591...120,621,997
JBrowse link
G Selenop selenoprotein P decreases expression ISO diethyl maleate results in decreased expression of SELENOP mRNA CTD PMID:30261343 NCBI chr15:3,300,249...3,309,992
Ensembl chr15:3,298,029...3,309,990
JBrowse link
G Serpinb6b serine (or cysteine) peptidase inhibitor, clade B, member 6b decreases expression EXP diethyl maleate results in decreased expression of SERPINB6B mRNA CTD PMID:25270620 NCBI chr13:33,140,797...33,163,050
Ensembl chr13:33,149,192...33,163,050
JBrowse link
G Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 decreases expression EXP diethyl maleate results in decreased expression of SERPIND1 mRNA CTD PMID:25270620 NCBI chr16:17,149,235...17,161,438
Ensembl chr16:17,149,235...17,161,439
JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO diethyl maleate results in increased expression of SERTAD1 mRNA CTD PMID:33545341 NCBI chr 7:27,186,378...27,189,741
Ensembl chr 7:27,186,335...27,189,741
JBrowse link
G Sez6 seizure related gene 6 decreases expression ISO diethyl maleate results in decreased expression of SEZ6 mRNA CTD PMID:21161181 NCBI chr11:77,821,403...77,869,874
Ensembl chr11:77,821,626...77,869,874
JBrowse link
G Sfxn1 sideroflexin 1 decreases expression EXP diethyl maleate results in decreased expression of SFXN1 mRNA CTD PMID:25270620 NCBI chr13:54,225,675...54,262,365
Ensembl chr13:54,225,888...54,262,361
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 (BTK-associated) increases expression
affects expression
ISO diethyl maleate results in increased expression of SH3BP5 mRNA
diethyl maleate affects the expression of SH3BP5 mRNA
CTD PMID:33545341 PMID:34480604 NCBI chr14:31,094,571...31,158,056
Ensembl chr14:31,081,837...31,158,035
JBrowse link
G Six4 sine oculis-related homeobox 4 increases expression EXP diethyl maleate results in increased expression of SIX4 mRNA CTD PMID:25270620 NCBI chr12:73,146,383...73,160,201
Ensembl chr12:73,146,383...73,160,230
JBrowse link
G Slc16a6 solute carrier family 16 (monocarboxylic acid transporters), member 6 decreases expression EXP diethyl maleate results in decreased expression of SLC16A6 mRNA CTD PMID:25270620 NCBI chr11:109,341,681...109,366,428
Ensembl chr11:109,341,681...109,364,424
JBrowse link
G Slc1a4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 increases expression EXP diethyl maleate results in increased expression of SLC1A4 mRNA CTD PMID:25270620 NCBI chr11:20,252,180...20,282,713
Ensembl chr11:20,252,180...20,282,713
JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 decreases expression ISO diethyl maleate results in decreased expression of SLC2A2 mRNA CTD PMID:21161181 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508
JBrowse link
G Slc2a5 solute carrier family 2 (facilitated glucose transporter), member 5 decreases expression ISO diethyl maleate results in decreased expression of SLC2A5 mRNA CTD PMID:21161181 NCBI chr 4:150,203,801...150,228,625
Ensembl chr 4:150,203,740...150,228,626
JBrowse link
G Slc39a14 solute carrier family 39 (zinc transporter), member 14 decreases expression EXP diethyl maleate results in decreased expression of SLC39A14 mRNA CTD PMID:25270620 NCBI chr14:70,540,916...70,588,873
Ensembl chr14:70,540,918...70,588,874
JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 increases expression ISO diethyl maleate results in increased expression of SLC3A2 mRNA CTD PMID:33545341 NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733
JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 multiple interactions ISO diethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA] CTD PMID:21303654 NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683
JBrowse link
G Slc44a4 solute carrier family 44, member 4 decreases expression ISO diethyl maleate results in decreased expression of SLC44A4 mRNA CTD PMID:21161181 NCBI chr17:35,133,200...35,149,412
Ensembl chr17:35,133,442...35,149,412
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions
increases expression
EXP
ISO
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA] CTD PMID:12235164 PMID:33545341 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 decreases expression ISO diethyl maleate results in decreased expression of SLCO2A1 mRNA CTD PMID:21161181 NCBI chr 9:102,885,686...102,973,201
Ensembl chr 9:102,865,911...102,973,201
JBrowse link
G Slfn3 schlafen 3 decreases expression ISO diethyl maleate results in decreased expression of SLFN3 mRNA CTD PMID:21161181 NCBI chr11:83,082,156...83,105,980
Ensembl chr11:83,082,156...83,105,980
JBrowse link
G Smc4 structural maintenance of chromosomes 4 increases expression ISO diethyl maleate results in increased expression of SMC4 mRNA CTD PMID:21161181 NCBI chr 3:68,912,071...68,941,956
Ensembl chr 3:68,912,071...68,941,956
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1, acid lysosomal increases expression
multiple interactions
increases activity
ISO diethyl maleate results in increased expression of SMPD1 mRNA
Dactinomycin inhibits the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]
diethyl maleate results in increased activity of SMPD1 protein
CTD PMID:25762726 NCBI chr 7:105,203,567...105,207,596
Ensembl chr 7:105,203,567...105,207,596
JBrowse link
G Smtn smoothelin increases expression ISO diethyl maleate results in increased expression of SMTN mRNA CTD PMID:21161181 NCBI chr11:3,467,522...3,489,337
Ensembl chr11:3,467,523...3,490,612
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression EXP diethyl maleate results in decreased expression of SOCS3 mRNA CTD PMID:25270620 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing decreases expression ISO diethyl maleate results in decreased expression of SORL1 mRNA CTD PMID:21161181 NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 increases expression ISO diethyl maleate results in increased expression of SOX9 mRNA CTD PMID:21161181 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586
JBrowse link
G Sp5 trans-acting transcription factor 5 decreases expression EXP diethyl maleate results in decreased expression of SP5 mRNA CTD PMID:25270620 NCBI chr 2:70,305,267...70,308,070
Ensembl chr 2:70,305,267...70,308,073
JBrowse link
G Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) increases expression ISO diethyl maleate results in increased expression of SPC25 mRNA CTD PMID:21161181 NCBI chr 2:69,009,753...69,036,583
Ensembl chr 2:69,024,239...69,036,538
JBrowse link
G Spta1 spectrin alpha, erythrocytic 1 increases expression EXP diethyl maleate results in increased expression of SPTA1 mRNA CTD PMID:25270620 NCBI chr 1:174,000,305...174,076,015
Ensembl chr 1:174,000,342...174,076,016
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 increases cleavage ISO diethyl maleate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463
JBrowse link
G Sptbn4 spectrin beta, non-erythrocytic 4 increases expression EXP diethyl maleate results in increased expression of SPTBN4 mRNA CTD PMID:25270620 NCBI chr 7:27,055,808...27,147,128
Ensembl chr 7:27,055,808...27,147,111
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 increases expression ISO diethyl maleate results in increased expression of SPTLC1 mRNA CTD PMID:33545341 NCBI chr13:53,486,784...53,531,401
Ensembl chr13:53,486,784...53,531,433
JBrowse link
G Sqstm1 sequestosome 1 increases expression EXP
ISO
diethyl maleate results in increased expression of SQSTM1 mRNA CTD PMID:25270620 PMID:33545341 PMID:34480604 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO diethyl maleate results in decreased expression of SREBF1 mRNA CTD PMID:21161181 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) multiple interactions
decreases expression
increases expression
EXP
ISO
[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
diethyl maleate results in decreased expression of SRXN1 mRNA
[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
diethyl maleate results in increased expression of SRXN1 mRNA; diethyl maleate results in increased expression of SRXN1 protein
CTD PMID:22003191 PMID:25270620 PMID:27358234 PMID:27982581 PMID:33545341 More... NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO diethyl maleate results in decreased expression of STAT1 mRNA CTD PMID:21161181 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Steap4 STEAP family member 4 decreases expression EXP diethyl maleate results in decreased expression of STEAP4 mRNA CTD PMID:25270620 NCBI chr 5:8,010,472...8,032,213
Ensembl chr 5:8,010,457...8,032,213
JBrowse link
G Sulf2 sulfatase 2 decreases expression ISO diethyl maleate results in decreased expression of SULF2 mRNA CTD PMID:21161181 NCBI chr 2:165,915,819...165,997,603
Ensembl chr 2:165,915,009...165,997,583
JBrowse link
G Tagln transgelin decreases expression ISO diethyl maleate results in decreased expression of TAGLN mRNA CTD PMID:21161181 NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356
JBrowse link
G Tatdn2 TatD DNase domain containing 2 increases expression ISO diethyl maleate results in increased expression of TATDN2 mRNA CTD PMID:33545341 NCBI chr 6:113,674,090...113,688,030
Ensembl chr 6:113,674,011...113,688,030
JBrowse link
G Tbcel tubulin folding cofactor E-like increases expression EXP diethyl maleate results in increased expression of TBCEL mRNA CTD PMID:25270620 NCBI chr 9:42,323,612...42,383,534
Ensembl chr 9:42,323,612...42,419,105
JBrowse link
G Tent4a terminal nucleotidyltransferase 4A increases expression ISO diethyl maleate results in increased expression of TENT4A mRNA CTD PMID:33545341 NCBI chr13:69,646,071...69,682,710
Ensembl chr13:69,646,078...69,682,736
JBrowse link
G Tent5a terminal nucleotidyltransferase 5A decreases expression ISO diethyl maleate results in decreased expression of TENT5A mRNA CTD PMID:21161181 NCBI chr 9:85,202,492...85,209,203
Ensembl chr 9:85,202,492...85,209,401
JBrowse link
G Tesmin testis expressed metallothionein like affects localization EXP diethyl maleate affects the localization of TESMIN protein CTD PMID:12606435 NCBI chr19:3,438,857...3,457,823
Ensembl chr19:3,438,857...3,457,823
JBrowse link
G Tfeb transcription factor EB decreases expression EXP diethyl maleate results in decreased expression of TFEB mRNA CTD PMID:25270620 NCBI chr17:48,047,962...48,103,341
Ensembl chr17:48,047,955...48,103,344
JBrowse link
G Tgm2 transglutaminase 2, C polypeptide increases expression ISO diethyl maleate results in increased expression of TGM2 mRNA CTD PMID:21161181 NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO diethyl maleate results in increased expression of THBS1 mRNA CTD PMID:21161181 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614
JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO diethyl maleate results in decreased expression of THRSP mRNA CTD PMID:21161181 NCBI chr 7:97,062,140...97,066,757
Ensembl chr 7:97,062,145...97,066,937
JBrowse link
G Tm4sf1 transmembrane 4 superfamily member 1 increases expression ISO diethyl maleate results in increased expression of TM4SF1 mRNA CTD PMID:21161181 NCBI chr 3:57,193,038...57,295,150
Ensembl chr 3:57,193,032...57,209,409
Ensembl chr 3:57,193,032...57,209,409
JBrowse link
G Tmem209 transmembrane protein 209 increases expression EXP diethyl maleate results in increased expression of TMEM209 mRNA CTD PMID:25270620 NCBI chr 6:30,480,806...30,509,786
Ensembl chr 6:30,479,052...30,509,782
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; [diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; [diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
CTD PMID:7476933 PMID:7532384 PMID:12774022 PMID:20116392 PMID:31958493 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions ISO diethyl maleate inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein] CTD PMID:35724838 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405
JBrowse link
G Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) decreases expression ISO diethyl maleate results in decreased expression of TNFRSF14 mRNA CTD PMID:21161181 NCBI chr 4:155,002,944...155,013,077
Ensembl chr 4:155,006,390...155,013,020
JBrowse link
G Tpm2 tropomyosin 2, beta decreases expression ISO diethyl maleate results in decreased expression of TPM2 mRNA CTD PMID:21161181 NCBI chr 4:43,513,726...43,523,583
Ensembl chr 4:43,514,711...43,523,765
JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions
decreases response to substance
ISO diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein]
TRAP1 protein results in decreased susceptibility to diethyl maleate
CTD PMID:17853063 NCBI chr16:3,857,835...3,895,704
Ensembl chr16:3,857,835...3,895,691
JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression EXP diethyl maleate results in decreased expression of TRDMT1 mRNA CTD PMID:25270620 NCBI chr 2:13,509,690...13,549,475
Ensembl chr 2:13,513,825...13,549,479
JBrowse link
G Trf transferrin decreases expression ISO diethyl maleate results in decreased expression of TF protein CTD PMID:21161181 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
JBrowse link
G Trib1 tribbles pseudokinase 1 increases expression ISO diethyl maleate results in increased expression of TRIB1 mRNA CTD PMID:33545341 NCBI chr15:59,520,503...59,528,948
Ensembl chr15:59,520,199...59,528,948
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO diethyl maleate results in increased expression of TRIB3 mRNA CTD PMID:33545341 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952
JBrowse link
G Trim6 tripartite motif-containing 6 decreases expression ISO diethyl maleate results in decreased expression of TRIM6 mRNA CTD PMID:21161181 NCBI chr 7:103,868,002...103,884,359
Ensembl chr 7:103,868,000...103,884,359
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 increases expression ISO diethyl maleate results in increased expression of TRIP13 mRNA CTD PMID:21161181 NCBI chr13:74,060,577...74,085,855
Ensembl chr13:74,059,466...74,085,903
JBrowse link
G Trp53 transformation related protein 53 multiple interactions EXP
ISO
TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD PMID:22003191 PMID:27982581 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO diethyl maleate results in decreased expression of TSC22D1 mRNA CTD PMID:21161181 NCBI chr14:76,652,401...76,745,205
Ensembl chr14:76,652,401...76,745,205
JBrowse link
G Tspan8 tetraspanin 8 decreases expression ISO diethyl maleate results in decreased expression of TSPAN8 mRNA CTD PMID:21161181 NCBI chr10:115,652,722...115,685,798
Ensembl chr10:115,652,737...115,685,798
JBrowse link
G Tstd1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 decreases expression EXP diethyl maleate results in decreased expression of TSTD1 mRNA CTD PMID:25270620 NCBI chr 1:171,246,601...171,247,920
Ensembl chr 1:171,246,440...171,247,920
JBrowse link
G Txn1 thioredoxin 1 decreases activity ISO diethyl maleate results in decreased activity of TXN protein CTD PMID:15388247 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO diethyl maleate results in increased expression of TXNIP mRNA CTD PMID:21161181 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO diethyl maleate results in increased expression of TXNRD1 mRNA CTD PMID:15521073 PMID:33545341 PMID:34480604 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Ubd ubiquitin D decreases expression ISO diethyl maleate results in decreased expression of UBD mRNA CTD PMID:21161181 NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986
JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases expression EXP diethyl maleate results in increased expression of UGT2B35 mRNA CTD PMID:25270620 NCBI chr 5:87,148,719...87,161,133
Ensembl chr 5:87,148,719...87,161,134
JBrowse link
G Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 increases expression ISO diethyl maleate results in increased expression of UHRF1 mRNA CTD PMID:21161181 NCBI chr17:56,610,405...56,630,486
Ensembl chr17:56,610,321...56,630,486
JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression ISO diethyl maleate results in decreased expression of USP18 mRNA CTD PMID:21161181 NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876
JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression ISO diethyl maleate results in decreased expression of USP2 mRNA CTD PMID:21161181 NCBI chr 9:43,978,318...44,006,924
Ensembl chr 9:43,978,318...44,006,924
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO diethyl maleate results in increased expression of VEGFA mRNA CTD PMID:33545341 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Wdr31 WD repeat domain 31 decreases expression EXP diethyl maleate results in decreased expression of WDR31 mRNA CTD PMID:25270620 NCBI chr 4:62,366,890...62,389,236
Ensembl chr 4:62,366,890...62,389,133
JBrowse link
G Wdr6 WD repeat domain 6 decreases expression ISO diethyl maleate results in decreased expression of WDR6 mRNA CTD PMID:21161181 NCBI chr 9:108,449,510...108,455,862
Ensembl chr 9:108,449,510...108,455,938
JBrowse link
G Ypel5 yippee like 5 increases expression EXP diethyl maleate results in increased expression of YPEL5 mRNA CTD PMID:25270620 NCBI chr17:73,143,623...73,157,439
Ensembl chr17:73,143,448...73,158,190
JBrowse link
G Zfand2a zinc finger, AN1-type domain 2A increases expression ISO diethyl maleate results in increased expression of ZFAND2A mRNA CTD PMID:33545341 PMID:34480604 NCBI chr 5:139,456,971...139,470,246
Ensembl chr 5:139,456,966...139,470,304
JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO diethyl maleate results in increased expression of ZFP36 protein CTD PMID:21969073 NCBI chr 7:28,076,208...28,078,680
Ensembl chr 7:28,076,209...28,079,678
JBrowse link
G Zfp367 zinc finger protein 367 increases expression ISO diethyl maleate results in increased expression of ZNF367 mRNA CTD PMID:21161181 NCBI chr13:64,280,836...64,301,013
Ensembl chr13:64,280,832...64,301,016
JBrowse link
G Zfp37 zinc finger protein 37 decreases expression ISO diethyl maleate results in decreased expression of ZFP37 mRNA CTD PMID:21161181 NCBI chr 4:62,107,777...62,126,685
Ensembl chr 4:62,107,777...62,149,284
JBrowse link
G Zfp493 zinc finger protein 493 decreases reduction EXP diethyl maleate results in decreased reduction of ZFP493 protein CTD PMID:19843705 NCBI chr13:67,927,812...67,937,201
Ensembl chr13:67,927,812...67,940,631
JBrowse link
G Znrd2 zinc ribbon domain containing 2 decreases expression EXP diethyl maleate results in decreased expression of ZNRD2 mRNA CTD PMID:25270620 NCBI chr19:5,780,334...5,781,760
Ensembl chr19:5,780,331...5,781,760
Ensembl chr19:5,780,331...5,781,760
JBrowse link
dimethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of ACSL4 protein] CTD PMID:35870111 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:30703375 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein] CTD PMID:36999408 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
JBrowse link
G Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 multiple interactions EXP Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA] CTD PMID:30742845 NCBI chr 4:19,876,838...19,922,566
Ensembl chr 4:19,876,841...19,922,605
JBrowse link
G Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 affects localization ISO Dimethyl Fumarate affects the localization of BACH1 protein CTD PMID:27277809 NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO Dimethyl Fumarate inhibits the reaction [Propylthiouracil results in decreased expression of BDNF mRNA]; Dimethyl Fumarate inhibits the reaction [Propylthiouracil results in decreased expression of BDNF protein] CTD PMID:35869475 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein] CTD PMID:36999408 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Cat catalase multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein] CTD PMID:36999408 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO
EXP
Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCL2 mRNA]
Dimethyl Fumarate results in decreased expression of CCL2 mRNA
CTD PMID:26683377 PMID:27277809 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Cd68 CD68 antigen multiple interactions EXP Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA] CTD PMID:27277809 NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979
JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CD74 mRNA] CTD PMID:30021835 NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724
JBrowse link
G Ciita class II transactivator multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CIITA mRNA] CTD PMID:30021835 NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions EXP Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
JBrowse link
G Ctsk cathepsin K multiple interactions EXP Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL10 mRNA] CTD PMID:30021835 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA] CTD PMID:30021835 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions
increases expression
ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of FTH1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]
Dimethyl Fumarate results in increased expression of FTH1 mRNA; Dimethyl Fumarate results in increased expression of FTH1 protein
CTD PMID:28289076 PMID:35870111 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
JBrowse link
G Ftl1 ferritin light polypeptide 1 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]
Dimethyl Fumarate results in increased expression of FTL mRNA; Dimethyl Fumarate results in increased expression of FTL protein
CTD PMID:28289076 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
EXP
ISO
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]
Dimethyl Fumarate results in increased expression of GCLC protein
CTD PMID:27277809 PMID:30248482 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression
multiple interactions
ISO
EXP
Dimethyl Fumarate results in increased expression of GCLM protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]
CTD PMID:27277809 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gpx4 glutathione peroxidase 4 increases metabolic processing
multiple interactions
ISO Dimethyl Fumarate results in increased metabolism of GPX4 protein
Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of GPX4 protein]
CTD PMID:29917289 PMID:35870111 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G Gsr glutathione reductase increases expression
multiple interactions
ISO
EXP
Dimethyl Fumarate results in increased expression of GSR protein
Dimethyl Fumarate results in increased expression of GSR mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]
CTD PMID:27277809 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G H2-Ea histocompatibility 2, class II antigen E alpha multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of HLA-DRA mRNA] CTD PMID:30021835 NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Dimethyl Fumarate results in increased expression of HMOX1 mRNA; Dimethyl Fumarate results in increased expression of HMOX1 protein
[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]
Acetylcysteine inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
[Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of HMOX1 protein]; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
CTD PMID:20961405 PMID:23942037 PMID:26683377 PMID:27277809 PMID:28790194 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
Dimethyl Fumarate results in decreased expression of ICAM1 mRNA
CTD PMID:26683377 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CD74 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CIITA mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL10 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of HLA-DRA mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]; Dimethyl Fumarate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]
Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]
CTD PMID:15663561 PMID:23942037 PMID:30021835 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein] CTD PMID:36999408 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA] CTD PMID:26683377 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
JBrowse link
G Il6ra interleukin 6 receptor, alpha decreases expression ISO Dimethyl Fumarate results in decreased expression of IL6R protein CTD PMID:28134847 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA] CTD PMID:30021835 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of LAMP2 protein alternative form] CTD PMID:29950142 NCBI chr  X:37,488,524...37,545,337
Ensembl chr  X:37,490,234...37,545,331
JBrowse link
G mt-Co3 cytochrome c oxidase III, mitochondrial increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of COX3 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA]
CTD PMID:27277809 NCBI chr MT:8,607...9,390
Ensembl chr MT:8,607...9,390
JBrowse link
G mt-Cytb cytochrome b, mitochondrial multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of CYTB mRNA] CTD PMID:27277809 NCBI chr MT:14,145...15,288
Ensembl chr MT:14,145...15,288
JBrowse link
G mt-Nd1 NADH dehydrogenase 1, mitochondrial increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of ND1 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND1 mRNA]
CTD PMID:27277809 NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707
JBrowse link
G mt-Nd2 NADH dehydrogenase 2, mitochondrial increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of ND2 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND2 mRNA]
CTD PMID:27277809 NCBI chr MT:3,914...4,951
Ensembl chr MT:3,914...4,951
JBrowse link
G mt-Nd5 NADH dehydrogenase 5, mitochondrial multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND5 mRNA] CTD PMID:27277809 NCBI chr MT:11,742...13,565
Ensembl chr MT:11,742...13,565
JBrowse link
G Mterf1a mitochondrial transcription termination factor 1a increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of MTERF1A mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF1A mRNA]
CTD PMID:27277809 NCBI chr 5:3,914,576...3,943,933
Ensembl chr 5:3,940,581...3,943,933
JBrowse link
G Mterf3 mitochondrial transcription termination factor 3 increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of MTERF3 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF3 mRNA]
CTD PMID:27277809 NCBI chr13:67,053,520...67,081,148
Ensembl chr13:67,055,032...67,081,152
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression
affects localization
EXP
ISO
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of CYTB mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of LAMP2 protein alternative form]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF1A mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF3 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND2 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND5 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLG2 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLRMT mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SSBP1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFAM mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB1M mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB2M mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TWNK mRNA]; NFE2L2 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein promotes the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]
[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of NFE2L2 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]
Dimethyl Fumarate results in increased expression of NFE2L2 protein
Dimethyl Fumarate affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
CTD PMID:23942037 PMID:27277809 PMID:28289076 PMID:28790194 PMID:29950142 More... NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein] CTD PMID:36999408 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein] CTD PMID:36999408 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases activity
increases expression
multiple interactions
ISO
EXP
Dimethyl Fumarate results in increased activity of NQO1 protein
Dimethyl Fumarate results in increased expression of NQO1 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of NQO1 mRNA]
Dimethyl Fumarate results in increased expression of NQO1 mRNA; Dimethyl Fumarate results in increased expression of NQO1 protein
[Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Mitomycin; [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Streptonigrin
CTD PMID:15655414 PMID:16045903 PMID:27277809 PMID:28790194 PMID:30248482 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide multiple interactions ISO [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein CTD PMID:20961405 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178
JBrowse link
G Polg2 polymerase (DNA directed), gamma 2, accessory subunit increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of POLG2 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLG2 mRNA]
CTD PMID:27277809 NCBI chr11:106,659,030...106,670,363
Ensembl chr11:106,659,079...106,670,363
JBrowse link
G Polrmt polymerase (RNA) mitochondrial (DNA directed) increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of POLRMT mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLRMT mRNA]
CTD PMID:27277809 NCBI chr10:79,571,951...79,582,436
Ensembl chr10:79,571,957...79,582,415
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Dimethyl Fumarate binds to and affects the localization of and results in decreased activity of RELA protein; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:26683377 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of RIPK3 protein] CTD PMID:36000575 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322
JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein] CTD PMID:35870111 NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein] CTD PMID:35870111 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein] CTD PMID:36999408 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SQSTM1 protein] CTD PMID:29950142 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Ssbp1 single-stranded DNA binding protein 1 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SSBP1 mRNA] CTD PMID:27277809 NCBI chr 6:40,448,302...40,458,757
Ensembl chr 6:40,448,286...40,461,634
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFAM mRNA] CTD PMID:27277809 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110
JBrowse link
G Tfb1m transcription factor B1, mitochondrial increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of TFB1M mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB1M mRNA]
CTD PMID:27277809 NCBI chr17:3,569,119...3,608,064
Ensembl chr17:3,569,531...3,608,056
JBrowse link
G Tfb2m transcription factor B2, mitochondrial increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of TFB2M mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB2M mRNA]
CTD PMID:27277809 NCBI chr 1:179,355,617...179,373,870
Ensembl chr 1:179,355,620...179,373,832
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:30703375 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased activity of RELA protein]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]
Dimethyl Fumarate results in decreased expression of TNF mRNA
CTD PMID:26683377 PMID:27277809 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions EXP Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
JBrowse link
G Twnk twinkle mtDNA helicase multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TWNK mRNA] CTD PMID:27277809 NCBI chr19:44,994,102...45,001,203
Ensembl chr19:44,994,102...45,001,201
JBrowse link
dimethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO dimethyl maleate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 increases cleavage ISO dimethyl maleate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463
JBrowse link
fumaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 multiple interactions EXP fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 protein] CTD PMID:23707484 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions EXP fumaric acid inhibits the reaction [TNF protein results in increased expression of CCR3 protein] CTD PMID:23707484 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726
JBrowse link
G Hlcs holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) decreases activity ISO fumaric acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr16:93,930,054...94,116,098
Ensembl chr16:93,929,741...94,114,430
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP fumaric acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:23707484 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Lepr leptin receptor affects abundance EXP LEPR affects the abundance of fumaric acid CTD PMID:20567778 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP fumaric acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:23707484 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP fumaric acid inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:23707484 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP fumaric acid inhibits the reaction [TNF protein affects the localization of RELA protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCR3 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fumaric acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:23707484 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP fumaric acid inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:23707484 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
goralatide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme increases expression
multiple interactions
decreases expression
EXP goralatide results in increased expression of ACE mRNA
[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]
goralatide results in decreased expression of ACE mRNA
CTD PMID:20096676 PMID:33007385 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions EXP ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein] CTD PMID:33007385 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
CTD PMID:31181250 PMID:33007385 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]
CTD PMID:31181250 PMID:33007385 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein] CTD PMID:33007385 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 affects abundance
multiple interactions
EXP BDKRB1 protein affects the abundance of goralatide
[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide
CTD PMID:20096676 NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:33007385 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Col3a1 collagen, type III, alpha 1 multiple interactions EXP ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] CTD PMID:33007385 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866
JBrowse link
G Gli1 GLI-Kruppel family member GLI1 multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]
CTD PMID:31181250 NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843
JBrowse link
G Gli2 GLI-Kruppel family member GLI2 multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]
CTD PMID:31181250 NCBI chr 1:118,761,791...118,987,578
Ensembl chr 1:118,761,862...118,981,349
JBrowse link
G Gli3 GLI-Kruppel family member GLI3 multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]
CTD PMID:31181250 NCBI chr13:15,638,308...15,904,611
Ensembl chr13:15,637,820...15,904,611
JBrowse link
G Mas1 MAS1 oncogene multiple interactions EXP ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] CTD PMID:33007385 NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030
JBrowse link
G Ptch1 patched 1 multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]
CTD PMID:31181250 NCBI chr13:63,656,142...63,721,274
Ensembl chr13:63,656,142...63,721,412
JBrowse link
G Shh sonic hedgehog multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]
CTD PMID:31181250 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254
JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]
CTD PMID:31181250 NCBI chr 6:29,735,480...29,761,359
Ensembl chr 6:29,735,502...29,761,364
JBrowse link
G Vim vimentin multiple interactions EXP goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:33007385 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
hydrocortisone succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP1A2 CTD PMID:18347083 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G F2 coagulation factor II affects expression ISO hydrocortisone hemisuccinate affects the expression of F2 protein CTD PMID:12542493 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
JBrowse link
G Il18 interleukin 18 decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL18 protein CTD PMID:20421217 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1b interleukin 1 beta decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL1B protein CTD PMID:20421217 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL6 protein CTD PMID:20421217 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of TNF protein CTD PMID:20421217 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
L-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor multiple interactions ISO [bafilomycin A1 co-treated with EGF protein] results in increased abundance of Aspartic Acid CTD PMID:22689575 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Srr serine racemase affects abundance
multiple interactions
increases metabolic processing
EXP SRR protein affects the abundance of Aspartic Acid
[SRR protein results in increased metabolism of Aspartic Acid] which results in increased abundance of D-Aspartic Acid
CTD PMID:27387750 NCBI chr11:74,794,853...74,818,427
Ensembl chr11:74,797,185...74,816,774
JBrowse link
malathion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1110032F04Rik RIKEN cDNA 1110032F04 gene decreases expression ISO Malathion results in decreased expression of C3ORF80 mRNA CTD PMID:37047231 NCBI chr 3:68,776,684...68,779,496
Ensembl chr 3:68,776,919...68,779,496
JBrowse link
G 1700024G13Rik RIKEN cDNA 1700024G13 gene decreases expression ISO Malathion results in decreased expression of C10ORF53 mRNA CTD PMID:37047231 NCBI chr14:32,098,459...32,110,330
Ensembl chr14:32,098,025...32,110,348
JBrowse link
G 1700031M16Rik RIKEN cDNA 1700031M16 gene decreases expression ISO Malathion results in decreased expression of C12ORF54 mRNA CTD PMID:37047231 NCBI chr15:98,296,326...98,314,016
Ensembl chr15:98,296,300...98,314,149
Ensembl chr15:98,296,300...98,314,149
JBrowse link
G A830018L16Rik RIKEN cDNA A830018L16 gene decreases expression ISO Malathion results in decreased expression of C8ORF34 mRNA CTD PMID:37047231 NCBI chr 1:11,484,121...12,046,126
Ensembl chr 1:11,484,329...12,046,125
JBrowse link
G AA467197 expressed sequence AA467197 increases expression ISO Malathion results in increased expression of C15ORF48 mRNA CTD PMID:37047231 NCBI chr 2:122,479,807...122,482,996
Ensembl chr 2:122,478,906...122,483,111
JBrowse link
G Acbd5 acyl-Coenzyme A binding domain containing 5 increases expression ISO Malathion results in increased expression of ACBD5 mRNA CTD PMID:37047231 NCBI chr 2:22,958,189...23,004,525
Ensembl chr 2:22,958,179...23,005,570
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Malathion co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]; Oximes analog inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]
[Endosulfan co-treated with Malathion] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in increased activity of ACHE protein; Taurine inhibits the reaction [Malathion results in decreased activity of ACHE protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]
CTD PMID:2380476 PMID:4859365 PMID:14713564 PMID:18617161 PMID:19429256 More... NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Acot6 acyl-CoA thioesterase 6 decreases expression ISO Malathion results in decreased expression of ACOT6 mRNA CTD PMID:37047231 NCBI chr12:84,147,538...84,158,128
Ensembl chr12:84,147,428...84,158,123
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 decreases expression EXP Malathion results in decreased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 7:119,217,035...119,261,738
Ensembl chr 7:119,206,249...119,261,738
JBrowse link
G Adam11 a disintegrin and metallopeptidase domain 11 increases methylation ISO Malathion results in increased methylation of ADAM11 promoter CTD PMID:37047231 NCBI chr11:102,652,261...102,671,089
Ensembl chr11:102,652,265...102,671,088
JBrowse link
G Adam32 a disintegrin and metallopeptidase domain 32 decreases expression ISO Malathion results in decreased expression of ADAM32 mRNA CTD PMID:37047231 NCBI chr 8:25,326,159...25,438,933
Ensembl chr 8:25,326,156...25,438,820
JBrowse link
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif 12 decreases expression ISO Malathion results in decreased expression of ADAMTS12 mRNA CTD PMID:37047231 NCBI chr15:11,064,781...11,349,321
Ensembl chr15:11,064,876...11,349,317
JBrowse link
G Adamts20 ADAM metallopeptidase with thrombospondin type 1 motif 20 decreases expression ISO Malathion results in decreased expression of ADAMTS20 mRNA CTD PMID:37047231 NCBI chr15:94,166,177...94,329,966
Ensembl chr15:94,168,044...94,363,299
JBrowse link
G Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif 6 increases expression ISO Malathion results in increased expression of ADAMTS6 mRNA CTD PMID:37047231 NCBI chr13:104,423,026...104,633,203
Ensembl chr13:104,424,343...104,633,203
JBrowse link
G Add3 adducin 3 increases expression ISO Malathion results in increased expression of ADD3 mRNA CTD PMID:19784758 NCBI chr19:53,128,874...53,235,518
Ensembl chr19:53,128,874...53,235,830
JBrowse link
G Adm adrenomedullin increases expression ISO Malathion results in increased expression of ADM mRNA CTD PMID:37047231 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027
JBrowse link
G Adra2a adrenergic receptor, alpha 2a increases expression ISO Malathion results in increased expression of ADRA2A mRNA CTD PMID:37047231 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413
JBrowse link
G Aff1 AF4/FMR2 family, member 1 increases expression ISO Malathion results in increased expression of AFF1 mRNA mutant form CTD PMID:28624474 NCBI chr 5:103,840,307...104,003,188
Ensembl chr 5:103,840,240...104,003,188
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO [prothioconazole co-treated with terbutylazine co-treated with bitertanol co-treated with cypermethrin co-treated with Malathion] results in increased activity of AHR protein CTD PMID:25684042 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases expression ISO Malathion results in increased expression of AKR1C2 mRNA CTD PMID:16079077 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
JBrowse link
G Akr1e1 aldo-keto reductase family 1, member E1 decreases expression ISO Malathion results in decreased expression of AKR1E2 mRNA CTD PMID:37047231 NCBI chr13:4,641,122...4,659,163
Ensembl chr13:4,640,749...4,659,173
JBrowse link
G Alkal2 ALK and LTK ligand 2 increases expression ISO Malathion results in increased expression of ALKAL2 mRNA CTD PMID:37047231 NCBI chr12:30,934,323...30,943,855
Ensembl chr12:30,934,321...30,943,853
JBrowse link
G Amot angiomotin decreases expression ISO Malathion results in decreased expression of AMOT mRNA CTD PMID:37047231 NCBI chr  X:144,229,420...144,288,145
Ensembl chr  X:144,229,421...144,288,177
JBrowse link
G Angptl2 angiopoietin-like 2 decreases expression ISO Malathion results in decreased expression of ANGPTL2 mRNA CTD PMID:37047231 NCBI chr 2:33,105,963...33,137,737
Ensembl chr 2:33,106,081...33,137,729
JBrowse link
G Angptl4 angiopoietin-like 4 decreases methylation
increases expression
ISO Malathion results in decreased methylation of ANGPTL4 promoter
Malathion results in increased expression of ANGPTL4 mRNA
CTD PMID:37047231 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804
JBrowse link
G Ank1 ankyrin 1, erythroid decreases expression ISO Malathion results in decreased expression of ANK1 mRNA CTD PMID:37047231 NCBI chr 8:23,464,852...23,640,517
Ensembl chr 8:23,464,860...23,640,513
JBrowse link
G Ankrd55 ankyrin repeat domain 55 increases expression ISO Malathion results in increased expression of ANKRD55 mRNA CTD PMID:37047231 NCBI chr13:112,424,985...112,523,391
Ensembl chr13:112,424,985...112,520,536
JBrowse link
G Aplf aprataxin and PNKP like factor decreases expression ISO Malathion results in decreased expression of APLF mRNA CTD PMID:37047231 NCBI chr 6:87,605,407...87,649,244
Ensembl chr 6:87,605,406...87,649,175
JBrowse link
G Aqp12 aquaporin 12 decreases expression ISO Malathion results in decreased expression of AQP12A mRNA CTD PMID:37047231 NCBI chr 1:92,934,056...92,939,991
Ensembl chr 1:92,934,056...92,939,991
JBrowse link
G Aqp9 aquaporin 9 increases expression ISO Malathion results in increased expression of AQP9 mRNA CTD PMID:37047231 NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] results in decreased activity of AR protein
Malathion results in decreased expression of AR mRNA
CTD PMID:23871939 PMID:36336997 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Armc3 armadillo repeat containing 3 decreases expression ISO Malathion results in decreased expression of ARMC3 mRNA CTD PMID:37047231 NCBI chr 2:19,203,676...19,315,054
Ensembl chr 2:19,204,113...19,315,052
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 decreases expression ISO Malathion results in decreased expression of ARNT2 mRNA CTD PMID:37047231 NCBI chr 7:83,895,486...84,059,201
Ensembl chr 7:83,895,486...84,059,384
JBrowse link
G Asic5 acid-sensing ion channel family member 5 increases expression ISO Malathion results in increased expression of ASIC5 mRNA CTD PMID:37047231 NCBI chr 3:81,889,600...81,928,540
Ensembl chr 3:81,889,597...81,928,540
JBrowse link
G Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 decreases expression ISO Malathion results in decreased expression of ATP2B3 mRNA CTD PMID:37047231 NCBI chr  X:72,546,356...72,632,267
Ensembl chr  X:72,546,692...72,614,611
JBrowse link
G B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 decreases expression ISO Malathion results in decreased expression of B4GALT1 mRNA CTD PMID:32069766 NCBI chr 4:40,804,602...40,855,711
Ensembl chr 4:40,804,602...40,854,005
JBrowse link
G B9d1 B9 protein domain 1 decreases expression ISO Malathion results in decreased expression of B9D1 mRNA CTD PMID:37047231 NCBI chr11:61,395,970...61,403,757
Ensembl chr11:61,395,970...61,403,757
JBrowse link
G Bax BCL2-associated X protein decreases expression
multiple interactions
increases expression
ISO
EXP
Malathion results in decreased expression of BAX mRNA
crocin inhibits the reaction [Malathion results in increased expression of BAX protein]
Plant Extracts inhibits the reaction [Malathion results in increased expression of BAX protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of BAX protein]
Acetylcysteine inhibits the reaction [Malathion results in increased expression of BAX protein]
CTD PMID:23774768 PMID:30769050 PMID:32120800 PMID:35274200 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases activity
decreases activity
ISO Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of BCHE protein]
Malathion results in increased activity of BCHE protein
CTD PMID:17364237 PMID:18617161 PMID:21983245 PMID:25180440 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
increases expression
multiple interactions
ISO
EXP
Malathion results in decreased expression of BCL2 mRNA
Malathion results in increased expression of BCL2 protein
Malathion results in increased expression of BCL2 mRNA
Acetylcysteine inhibits the reaction [Malathion results in decreased expression of BCL2 protein]
CTD PMID:23774768 PMID:30673264 PMID:30769050 PMID:32120800 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bdnf brain derived neurotrophic factor increases methylation
decreases secretion
ISO Malathion results in increased methylation of BDNF protein
Malathion results in decreased secretion of BDNF protein
CTD PMID:35292247 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Bmi1 Bmi1 polycomb ring finger oncogene increases expression ISO Malathion results in increased expression of BMI1 mRNA CTD PMID:32069766 NCBI chr 2:18,681,953...18,691,440
Ensembl chr 2:18,681,829...18,691,440
JBrowse link
G Brd7 bromodomain containing 7 increases expression EXP Malathion results in increased expression of BRD7 mRNA CTD PMID:18214912 NCBI chr 8:89,056,522...89,089,249
Ensembl chr 8:89,057,667...89,088,822
JBrowse link
G Bsnd barttin CLCNK type accessory beta subunit increases expression ISO Malathion results in increased expression of BSND mRNA CTD PMID:37047231 NCBI chr 4:106,340,653...106,349,440
Ensembl chr 4:106,340,653...106,349,480
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Malathion results in decreased expression of BTG1 mRNA CTD PMID:32069766 NCBI chr10:96,452,863...96,458,675
Ensembl chr10:96,452,868...96,458,671
JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase decreases expression ISO Malathion results in decreased expression of BUB1 mRNA CTD PMID:16079077 NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785
JBrowse link
G C1ql2 complement component 1, q subcomponent-like 2 decreases expression ISO Malathion results in decreased expression of C1QL2 mRNA CTD PMID:37047231 NCBI chr 1:120,268,312...120,270,903
Ensembl chr 1:120,268,312...120,270,903
JBrowse link
G Cabp7 calcium binding protein 7 decreases expression ISO Malathion results in decreased expression of CABP7 mRNA CTD PMID:37047231 NCBI chr11:4,686,892...4,697,179
Ensembl chr11:4,686,892...4,696,778
JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit increases expression ISO Malathion results in increased expression of CACNA1C mRNA CTD PMID:37047231 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA] CTD PMID:28385489 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II, beta multiple interactions ISO Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA] CTD PMID:28385489 NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362
JBrowse link
G Capn8 calpain 8 decreases expression ISO Malathion results in decreased expression of CAPN8 mRNA CTD PMID:37047231 NCBI chr 1:182,392,314...182,462,021
Ensembl chr 1:182,392,572...182,459,917
JBrowse link
G Cartpt CART prepropeptide increases expression ISO Malathion results in increased expression of CARTPT mRNA CTD PMID:37047231 NCBI chr13:100,034,991...100,037,191
Ensembl chr13:100,034,997...100,037,599
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
increases expression
EXP
ISO
Malathion results in increased activity of CASP3 protein
Malathion results in increased cleavage of CASP3 protein
Malathion results in increased activity of and results in increased cleavage of CASP3 protein; Metoclopramide inhibits the reaction [Malathion results in increased activity of and results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
Malathion results in increased expression of CASP3 mRNA
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
CTD PMID:12505448 PMID:19815060 PMID:21628957 PMID:27941166 PMID:29027213 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase decreases expression ISO Malathion results in decreased expression of CASP4 mRNA CTD PMID:32069766 NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Casp8 caspase 8 increases activity EXP Malathion results in increased activity of CASP8 protein CTD PMID:12505448 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
multiple interactions
increases expression
EXP
ISO
Malathion results in increased activity of CASP9 protein
Malathion results in increased cleavage of CASP9 protein
Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP9 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
CTD PMID:12505448 PMID:21628957 PMID:27941166 PMID:30769050 PMID:35274200 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions
decreases activity
decreases expression
increases activity
ISO
EXP
[Dimethoate co-treated with Malathion] results in increased activity of CAT protein; [Selenium co-treated with Vitamin E] inhibits the reaction [Malathion results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; Pentoxifylline inhibits the reaction [Malathion results in increased activity of CAT protein]; Taurine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of CAT protein]
Malathion results in decreased expression of CAT protein
[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Malathion results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [Malathion results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]
[Malathion co-treated with 1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide] results in increased activity of CAT protein; [Malathion co-treated with pralidoxime] results in increased activity of CAT protein; lavender oil inhibits the reaction [Malathion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Malathion results in decreased activity of CAT protein]; Polyphenols inhibits the reaction [Malathion results in decreased activity of CAT protein]
CTD PMID:11834209 PMID:18655177 PMID:19429256 PMID:20194575 PMID:21628957 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cbfb core binding factor beta increases expression ISO Malathion results in increased expression of CBFB mRNA CTD PMID:32069766 NCBI chr 8:105,897,306...105,944,621
Ensembl chr 8:105,897,306...105,944,621
JBrowse link
G Ccdc126 coiled-coil domain containing 126 increases expression ISO Malathion results in increased expression of CCDC126 mRNA CTD PMID:37047231 NCBI chr 6:49,296,204...49,318,521
Ensembl chr 6:49,296,208...49,318,516
JBrowse link
G Ccdc192 coiled-coil domain containing 192 increases expression ISO Malathion results in increased expression of CCDC192 mRNA CTD PMID:37047231 NCBI chr18:57,666,814...57,864,139
Ensembl chr18:57,666,852...57,864,137
JBrowse link
G Cck cholecystokinin increases expression ISO Malathion results in increased expression of CCK mRNA CTD PMID:19784758 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 increases expression ISO Malathion results in increased expression of CCL1 mRNA CTD PMID:37047231 NCBI chr11:82,067,492...82,070,638
Ensembl chr11:82,067,483...82,196,516
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression ISO Malathion results in increased expression of CCL19 mRNA CTD PMID:37047231 NCBI chr 4:42,754,525...42,756,558
Ensembl chr 4:42,754,525...42,756,577
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Malathion results in increased expression of CCL20 mRNA CTD PMID:37047231 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Malathion results in increased expression of CCL3 mRNA CTD PMID:37047231 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO Malathion results in increased expression of CCL7 mRNA CTD PMID:37047231 NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351
JBrowse link
G Ccm2l cerebral cavernous malformation 2-like increases expression ISO Malathion results in increased expression of CCM2L mRNA CTD PMID:37047231 NCBI chr 2:152,907,857...152,923,655
Ensembl chr 2:152,907,875...152,923,655
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Malathion results in decreased expression of CCNA2 protein CTD PMID:30769050 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Malathion results in decreased expression of CCNB1 protein CTD PMID:30769050 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Malathion results in decreased expression of CCNE1 protein CTD PMID:30769050 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Ccser1 coiled-coil serine rich 1 increases expression ISO Malathion results in increased expression of CCSER1 mRNA CTD PMID:37047231 NCBI chr 6:61,156,942...62,359,847
Ensembl chr 6:61,157,308...62,359,849
JBrowse link
G Cd14 CD14 antigen decreases expression ISO Malathion results in decreased expression of CD14 mRNA CTD PMID:32069766 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
JBrowse link
G Cd274 CD274 antigen increases expression ISO Malathion results in increased expression of CD274 mRNA CTD PMID:37047231 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495
JBrowse link
G Cd36 CD36 molecule increases expression ISO Malathion results in increased expression of CD36 mRNA CTD PMID:32069766 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cd5 CD5 antigen decreases expression ISO Malathion results in decreased expression of CD5 mRNA CTD PMID:32069766 NCBI chr19:10,695,471...10,716,390
Ensembl chr19:10,694,480...10,716,366
JBrowse link
G Cd69 CD69 antigen increases expression ISO Malathion results in increased expression of CD69 mRNA CTD PMID:37047231 NCBI chr 6:129,244,287...129,252,332
Ensembl chr 6:129,244,288...129,252,399
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO Malathion results in decreased expression of CDC20 mRNA CTD PMID:18214805 NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549
JBrowse link
G Cdk15 cyclin dependent kinase 15 increases expression ISO Malathion results in increased expression of CDK15 mRNA CTD PMID:37047231 NCBI chr 1:59,296,029...59,391,656
Ensembl chr 1:59,296,065...59,392,152
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
increases expression
ISO Malathion results in decreased expression of CDK2 protein
Malathion results in increased expression of CDK2 mRNA
CTD PMID:30769050 PMID:32069766 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO Malathion results in increased expression of CEBPG mRNA CTD PMID:32069766 NCBI chr 7:34,745,847...34,755,991
Ensembl chr 7:34,745,847...34,755,998
JBrowse link
G Cenpf centromere protein F decreases expression ISO Malathion results in decreased expression of CENPF mRNA CTD PMID:16079077 NCBI chr 1:189,372,803...189,420,302
Ensembl chr 1:189,372,803...189,420,283
JBrowse link
G Ces1d carboxylesterase 1D increases expression EXP Malathion results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
JBrowse link
G Cfap157 cilia and flagella associated protein 157 decreases expression ISO Malathion results in decreased expression of CFAP157 mRNA CTD PMID:37047231 NCBI chr 2:32,667,425...32,674,417
Ensembl chr 2:32,667,393...32,674,440
JBrowse link
G Cfap91 cilia and flagella associated protein 91 decreases expression ISO Malathion results in decreased expression of CFAP91 mRNA CTD PMID:37047231 NCBI chr16:38,118,116...38,162,222
Ensembl chr16:38,118,116...38,162,505
JBrowse link
G Cfb complement factor B increases expression ISO Malathion results in increased expression of CFB mRNA CTD PMID:37047231 NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494
JBrowse link
G Ch25h cholesterol 25-hydroxylase increases expression ISO Malathion results in increased expression of CH25H mRNA CTD PMID:37047231 NCBI chr19:34,451,183...34,452,548
Ensembl chr19:34,451,178...34,452,564
JBrowse link
G Cldn12 claudin 12 increases expression ISO Malathion results in increased expression of CLDN12 mRNA CTD PMID:37047231 NCBI chr 5:5,555,109...5,564,953
Ensembl chr 5:5,539,537...5,564,958
JBrowse link
G Cldn22 claudin 22 decreases expression ISO Malathion results in decreased expression of CLDN22 mRNA CTD PMID:37047231 NCBI chr 8:48,277,501...48,278,511
Ensembl chr 8:48,277,517...48,278,511
JBrowse link
G Cldn5 claudin 5 multiple interactions
decreases expression
ISO [Malathion co-treated with Lead] results in decreased expression of CLDN5 protein
Malathion results in decreased expression of CLDN5 protein
CTD PMID:20970449 NCBI chr16:18,595,597...18,597,012
Ensembl chr16:18,595,597...18,597,012
JBrowse link
G Cma1 chymase 1, mast cell decreases expression ISO Malathion results in decreased expression of CMA1 mRNA CTD PMID:37047231 NCBI chr14:56,178,908...56,182,132
Ensembl chr14:56,178,908...56,182,132
JBrowse link
G Cntn4 contactin 4 increases expression ISO Malathion results in increased expression of CNTN4 mRNA CTD PMID:37047231 NCBI chr 6:105,654,505...106,677,102
Ensembl chr 6:105,654,621...106,676,271
JBrowse link
G Col1a2 collagen, type I, alpha 2 increases expression ISO Malathion results in increased expression of COL1A2 mRNA CTD PMID:32069766 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Cpne9 copine family member IX decreases expression ISO Malathion results in decreased expression of CPNE9 mRNA CTD PMID:37047231 NCBI chr 6:113,259,244...113,282,532
Ensembl chr 6:113,259,268...113,282,588
JBrowse link
G Cpz carboxypeptidase Z decreases expression ISO Malathion results in decreased expression of CPZ mRNA CTD PMID:37047231 NCBI chr 5:35,659,562...35,682,970
Ensembl chr 5:35,659,562...35,683,042
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
decreases expression
ISO caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA] CTD PMID:20233601 PMID:25404496 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560
JBrowse link
G Crisp3 cysteine-rich secretory protein 3 decreases expression ISO Malathion results in decreased expression of CRISP3 mRNA CTD PMID:37047231 NCBI chr17:40,532,668...40,553,179
Ensembl chr17:40,532,668...40,553,179
JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 decreases expression ISO Malathion results in decreased expression of CRISPLD2 mRNA CTD PMID:19784758 NCBI chr 8:120,719,177...120,779,533
Ensembl chr 8:120,719,177...120,779,532
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) increases expression ISO Malathion results in increased expression of CSF2 protein
Malathion results in increased expression of CSF2 mRNA
CTD PMID:34778934 PMID:37047231 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) increases expression ISO Malathion results in increased expression of CSF3 mRNA CTD PMID:37047231 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455
JBrowse link
G Ctsd cathepsin D increases expression EXP Malathion results in increased expression of CTSD protein CTD PMID:8812242 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
JBrowse link
G Cxcl11 chemokine (C-X-C motif) ligand 11 increases expression ISO Malathion results in increased expression of CXCL11 mRNA CTD PMID:37047231 NCBI chr 5:92,507,403...92,511,155
Ensembl chr 5:92,507,403...92,513,344
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO Malathion results in increased expression of CXCL8 mRNA CTD PMID:37047231 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions
increases expression
EXP Plant Extracts inhibits the reaction [Malathion results in increased expression of CYBB protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of CYBB protein] CTD PMID:32120800 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cym chymosin decreases expression ISO Malathion results in decreased expression of CYMP mRNA CTD PMID:37047231 NCBI chr 3:107,118,611...107,129,048
Ensembl chr 3:107,118,609...107,129,048
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression
EXP lavender oil inhibits the reaction [Malathion results in decreased expression of CYP11A1 mRNA] CTD PMID:30409133 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO [bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion co-treated with terbutylazine] results in increased expression of CYP19A1 mRNA CTD PMID:23954766 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases expression
ISO CYP1A2 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP1A2 mRNA
CTD PMID:15557345 PMID:22310298 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression ISO Malathion results in increased expression of CYP27B1 mRNA CTD PMID:37047231 NCBI chr10:126,884,115...126,891,897
Ensembl chr10:126,884,119...126,888,875
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 increases expression ISO Malathion results in increased expression of CYP2A6 mRNA CTD PMID:22310298 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases activity
multiple interactions
increases expression
affects metabolic processing
ISO Malathion results in decreased activity of CYP2B6 protein
Malathion promotes the reaction [isomalathion results in increased expression of CYP2B6 mRNA]
Malathion results in increased expression of CYP2B6 mRNA
CYP2B6 protein affects the metabolism of Malathion
CTD PMID:15557345 PMID:22310298 PMID:24333466 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity
multiple interactions
ISO Malathion results in decreased activity of CYP2C9 protein
Malathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]
CTD PMID:20183062 PMID:22634058 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Malathion results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 affects metabolic processing
increases expression
ISO CYP3A7 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP3A5 mRNA
CYP3A5 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP3A7 mRNA
CTD PMID:17110060 PMID:37047231 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
JBrowse link
G Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 multiple interactions ISO [Insecticides results in increased abundance of Malathion] which affects the methylation of CYP8B1 gene CTD PMID:34516295 NCBI chr 9:121,743,422...121,745,371
Ensembl chr 9:121,743,422...121,745,371
JBrowse link
G Dcn decorin increases expression ISO Malathion results in increased expression of DCN mRNA CTD PMID:37047231 NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005
JBrowse link
G Ddc dopa decarboxylase affects binding
increases expression
ISO Malathion binds to [DDC protein binds to Pyridoxal Phosphate]; Malathion binds to DDC protein
Malathion results in increased expression of DDC mRNA
CTD PMID:35151785 PMID:37047231 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144
JBrowse link
G Ddr1 discoidin domain receptor family, member 1 decreases expression ISO Malathion results in decreased expression of DDR1 mRNA CTD PMID:37047231 NCBI chr17:35,992,459...36,015,633
Ensembl chr17:35,992,459...36,015,513
JBrowse link
G Ddx11 DEAD/H box helicase 11 increases expression ISO Malathion results in increased expression of DDX11 mRNA CTD PMID:32069766 NCBI chr17:66,430,508...66,459,169
Ensembl chr17:66,430,515...66,459,169
JBrowse link
G Dio1 deiodinase, iodothyronine, type I decreases expression ISO Malathion results in decreased expression of DIO1 mRNA CTD PMID:37047231 NCBI chr 4:107,148,662...107,164,365
Ensembl chr 4:107,148,662...107,164,366
JBrowse link
G Disc1 disrupted in schizophrenia 1 increases expression ISO Malathion results in increased expression of DISC1 mRNA CTD PMID:37047231 NCBI chr 8:125,773,928...125,991,882
Ensembl chr 8:125,780,934...125,988,597
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 increases expression ISO Malathion results in increased expression of DKK2 mRNA CTD PMID:37047231 NCBI chr 3:131,791,027...131,886,065
Ensembl chr 3:131,791,053...131,886,065
JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression ISO Malathion results in increased expression of DLG2 mRNA CTD PMID:37047231 NCBI chr 7:90,125,399...92,098,454
Ensembl chr 7:90,125,880...92,098,455
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO Malathion results in decreased expression of DNMT1 mRNA CTD PMID:36370973 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
JBrowse link
G Dnmt3a DNA methyltransferase 3A affects expression ISO Malathion affects the expression of DNMT3A mRNA CTD PMID:36370973 NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443
JBrowse link
G Dnmt3b DNA methyltransferase 3B affects expression ISO Malathion affects the expression of DNMT3B mRNA CTD PMID:36370973 NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650
JBrowse link
G Doc2b double C2, beta decreases expression ISO Malathion results in decreased expression of DOC2B mRNA CTD PMID:37047231 NCBI chr11:75,659,096...75,686,886
Ensembl chr11:75,659,792...75,686,875
JBrowse link
G Dsp desmoplakin increases expression ISO Malathion results in increased expression of DSP mRNA CTD PMID:37047231 NCBI chr13:38,335,357...38,382,553
Ensembl chr13:38,335,270...38,382,553
JBrowse link
G Dspp dentin sialophosphoprotein decreases expression ISO Malathion results in decreased expression of DSPP mRNA CTD PMID:37047231 NCBI chr 5:104,318,569...104,327,993
Ensembl chr 5:104,318,578...104,327,993
JBrowse link
G Dtna dystrobrevin alpha decreases expression ISO Malathion results in decreased expression of DTNA mRNA CTD PMID:37047231 NCBI chr18:23,443,063...23,792,776
Ensembl chr18:23,548,192...23,792,772
JBrowse link
G Duox1 dual oxidase 1 increases expression
multiple interactions
EXP Malathion results in increased expression of DUOX1 protein
Plant Extracts inhibits the reaction [Malathion results in increased expression of DUOX1 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of DUOX1 protein]
CTD PMID:32120800 NCBI chr 2:122,143,525...122,178,454
Ensembl chr 2:122,146,153...122,178,453
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression ISO Malathion results in decreased expression of DUSP1 mRNA CTD PMID:32069766 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Malathion results in increased expression of DUSP5 mRNA CTD PMID:37047231 NCBI chr19:53,517,576...53,530,240
Ensembl chr19:53,517,540...53,530,862
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 increases expression ISO Malathion results in increased expression of DVL1 mRNA CTD PMID:18204794 NCBI chr 4:155,931,829...155,943,760
Ensembl chr 4:155,931,859...155,943,760
JBrowse link
G Ebi3 Epstein-Barr virus induced gene 3 increases expression ISO Malathion results in increased expression of EBI3 mRNA CTD PMID:37047231 NCBI chr17:56,259,623...56,264,022
Ensembl chr17:56,259,640...56,264,022
JBrowse link
G Edn1 endothelin 1 increases expression ISO Malathion results in increased expression of EDN1 mRNA CTD PMID:37047231 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Ednrb endothelin receptor type B decreases expression ISO Malathion results in decreased expression of EDNRB mRNA CTD PMID:37047231 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838
JBrowse link
G Efcab9 EF-hand calcium binding domain 9 increases expression ISO Malathion results in increased expression of EFCAB9 mRNA CTD PMID:37047231 NCBI chr11:32,472,733...32,483,144
Ensembl chr11:32,472,751...32,482,081
JBrowse link
G Ehbp1 EH domain binding protein 1 increases response to substance ISO EHBP1 gene SNP results in increased susceptibility to Malathion CTD PMID:23593118 NCBI chr11:21,955,825...22,237,086
Ensembl chr11:21,955,828...22,292,292
JBrowse link
G En1 engrailed 1 decreases expression ISO Malathion results in decreased expression of EN1 mRNA CTD PMID:37047231 NCBI chr 1:120,530,246...120,535,719
Ensembl chr 1:120,530,147...120,535,721
JBrowse link
G Enkur enkurin, TRPC channel interacting protein increases expression ISO Malathion results in increased expression of ENKUR mRNA CTD PMID:37047231 NCBI chr 2:21,185,542...21,210,176
Ensembl chr 2:21,185,542...21,210,176
JBrowse link
G Epha10 Eph receptor A10 increases expression ISO Malathion results in increased expression of EPHA10 mRNA CTD PMID:37047231 NCBI chr 4:124,775,408...124,811,594
Ensembl chr 4:124,774,692...124,811,593
JBrowse link
G Epha4 Eph receptor A4 increases expression ISO Malathion results in increased expression of EPHA4 mRNA CTD PMID:32069766 NCBI chr 1:77,343,819...77,491,763
Ensembl chr 1:77,343,822...77,491,725
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal decreases expression EXP Malathion results in decreased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469
JBrowse link
G Epop elongin BC and polycomb repressive complex 2 associated protein increases expression ISO Malathion results in increased expression of EPOP mRNA CTD PMID:37047231 NCBI chr11:97,518,213...97,520,542
Ensembl chr11:97,518,215...97,520,528
JBrowse link
G Eps8l1 EPS8-like 1 increases expression ISO Malathion results in increased expression of EPS8L1 mRNA CTD PMID:32069766 NCBI chr 7:4,463,636...4,483,486
Ensembl chr 7:4,463,673...4,483,486
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 increases expression ISO Malathion results in increased expression of ERBB4 mRNA CTD PMID:37047231 NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218
JBrowse link
G Esr1 estrogen receptor 1 (alpha) decreases activity ISO Malathion results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Etv6 ets variant 6 increases expression ISO Malathion results in increased expression of ETV6 mRNA mutant form CTD PMID:28624474 NCBI chr 6:134,012,663...134,247,121
Ensembl chr 6:134,012,663...134,247,121
JBrowse link
G F3 coagulation factor III increases expression ISO Malathion results in increased expression of F3 mRNA CTD PMID:37047231 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Fam124a family with sequence similarity 124, member A increases expression ISO Malathion results in increased expression of FAM124A mRNA CTD PMID:37047231 NCBI chr14:62,793,186...62,845,935
Ensembl chr14:62,793,186...62,845,935
JBrowse link
G Fam227b family with sequence similarity 227, member B decreases expression ISO Malathion results in decreased expression of FAM227B mRNA CTD PMID:37047231 NCBI chr 2:125,825,403...125,994,048
Ensembl chr 2:125,825,403...125,993,924
JBrowse link
G Fam229b family with sequence similarity 229, member B decreases expression ISO Malathion results in decreased expression of FAM229B mRNA CTD PMID:37047231 NCBI chr10:38,994,800...39,009,936
Ensembl chr10:38,994,800...39,009,910
JBrowse link
G Fgf22 fibroblast growth factor 22 decreases expression ISO Malathion results in decreased expression of FGF22 mRNA CTD PMID:37047231 NCBI chr10:79,590,887...79,593,629
Ensembl chr10:79,590,910...79,594,430
JBrowse link
G Fgf6 fibroblast growth factor 6 increases expression ISO Malathion results in increased expression of FGF6 mRNA CTD PMID:32069766 NCBI chr 6:126,992,505...127,001,681
Ensembl chr 6:126,992,549...127,005,150
JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 increases expression ISO Malathion results in increased expression of FGFBP1 mRNA CTD PMID:37047231 NCBI chr 5:44,136,200...44,139,173
Ensembl chr 5:44,136,200...44,139,121
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 increases expression ISO Malathion results in increased expression of FGFR1 mRNA CTD PMID:32069766 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734
JBrowse link
G Fgg fibrinogen gamma chain decreases expression ISO Malathion results in decreased expression of FGG mRNA CTD PMID:37047231 NCBI chr 3:82,915,031...82,922,363
Ensembl chr 3:82,915,031...82,922,356
JBrowse link
G Filip1l filamin A interacting protein 1-like increases expression ISO Malathion results in increased expression of FILIP1L mRNA CTD PMID:37047231 NCBI chr16:57,173,376...57,393,167
Ensembl chr16:57,173,456...57,393,489
JBrowse link
G Flt4 FMS-like tyrosine kinase 4 increases expression ISO Malathion results in increased expression of FLT4 mRNA CTD PMID:37047231 NCBI chr11:49,500,506...49,543,566
Ensembl chr11:49,500,090...49,543,566
JBrowse link
G Foxo1 forkhead box O1 decreases expression
increases methylation
multiple interactions
ISO Malathion results in decreased expression of FOXO1 mRNA
Malathion results in increased methylation of FOXO1 promoter
[Malathion results in increased methylation of FOXO1 promoter] which results in decreased expression of FOXO1 mRNA
CTD PMID:36370973 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Foxo4 forkhead box O4 increases expression ISO Malathion results in increased expression of FOXO4 mRNA CTD PMID:32069766 NCBI chr  X:100,297,855...100,304,479
Ensembl chr  X:100,298,134...100,304,479
JBrowse link
G Fshr follicle stimulating hormone receptor increases expression ISO Malathion results in increased expression of FSHR mRNA CTD PMID:32069766 NCBI chr17:89,292,380...89,508,103
Ensembl chr17:89,292,380...89,508,103
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions
increases activity
ISO [Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]
Malathion results in increased activity of G6PD protein
CTD PMID:27214522 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800
JBrowse link
G Gad1 glutamate decarboxylase 1 affects binding ISO Malathion binds to [GAD1 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD1 protein CTD PMID:35151785 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
JBrowse link
G Gad2 glutamic acid decarboxylase 2 affects binding ISO Malathion binds to [GAD2 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD2 protein CTD PMID:35151785 NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886
JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 increases expression ISO Malathion results in increased expression of GALNT16 mRNA CTD PMID:37047231 NCBI chr12:80,565,245...80,650,672
Ensembl chr12:80,565,051...80,677,746
JBrowse link
G Garin2 golgi associated RAB2 interactor 2 decreases expression ISO Malathion results in decreased expression of GARIN2 mRNA CTD PMID:37047231 NCBI chr12:78,738,257...78,781,290
Ensembl chr12:78,738,309...78,781,290
JBrowse link
G Gas2 growth arrest specific 2 increases expression ISO Malathion results in increased expression of GAS2 mRNA CTD PMID:37047231 NCBI chr 7:51,511,560...51,644,753
Ensembl chr 7:51,511,763...51,644,723
JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO Malathion results in decreased expression of GATA4 mRNA CTD PMID:37047231 NCBI chr14:63,436,363...63,509,161
Ensembl chr14:63,436,371...63,509,141
JBrowse link
G Gbp2b guanylate binding protein 2b increases expression ISO Malathion results in increased expression of GBP1 mRNA CTD PMID:37047231 NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940
JBrowse link
G Gbp5 guanylate binding protein 5 increases expression ISO Malathion results in increased expression of GBP5 mRNA CTD PMID:37047231 NCBI chr 3:142,202,695...142,228,105
Ensembl chr 3:142,199,739...142,228,105
JBrowse link
G Gk glycerol kinase multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [Malathion results in increased activity of GK protein] CTD PMID:25449180 NCBI chr  X:84,745,543...84,820,425
Ensembl chr  X:84,745,543...84,820,425
JBrowse link
G Gk2 glycerol kinase 2 decreases expression ISO Malathion results in decreased expression of GK2 mRNA CTD PMID:25449180 NCBI chr 5:97,602,989...97,604,882
Ensembl chr 5:97,603,001...97,604,880
JBrowse link
G Gm13889 predicted gene 13889 increases expression ISO Malathion results in increased expression of C11ORF96 mRNA CTD PMID:37047231 NCBI chr 2:93,786,155...93,787,445
Ensembl chr 2:93,786,155...93,787,546
JBrowse link
G Gm20348 predicted gene, 20348 increases expression
multiple interactions
ISO Malathion results in increased expression of TP53I3 mRNA
[Malathion co-treated with Estrogens] results in increased expression of TP53I3 mRNA
CTD PMID:18204794 NCBI chr12:4,860,475...4,867,155
Ensembl chr12:4,860,494...4,867,142
JBrowse link
G Gmnc geminin coiled-coil domain containing increases expression ISO Malathion results in increased expression of GMNC mRNA CTD PMID:37047231 NCBI chr16:26,775,985...26,810,424
Ensembl chr16:26,732,303...26,810,402
JBrowse link
G Gnai1 G protein subunit alpha i1 increases expression ISO Malathion results in increased expression of GNAI1 mRNA CTD PMID:37047231 NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression ISO Malathion results in decreased expression of GNAI2 mRNA CTD PMID:32069766 NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566
JBrowse link
G Got1l1 glutamic-oxaloacetic transaminase 1-like 1 increases expression ISO Malathion results in increased expression of GOT1L1 mRNA CTD PMID:37047231 NCBI chr 8:27,687,487...27,713,872
Ensembl chr 8:27,687,487...27,713,856
JBrowse link
G Gp5 glycoprotein 5 platelet increases expression ISO Malathion results in increased expression of GP5 mRNA CTD PMID:37047231 NCBI chr16:30,126,503...30,129,599
Ensembl chr16:30,126,503...30,129,597
JBrowse link
G Gpr179 G protein-coupled receptor 179 decreases expression ISO Malathion results in decreased expression of GPR179 mRNA CTD PMID:37047231 NCBI chr11:97,222,935...97,243,182
Ensembl chr11:97,222,935...97,242,903
JBrowse link
G Gps2 G protein pathway suppressor 2 decreases expression ISO Malathion results in decreased expression of GPS2 mRNA CTD PMID:32069766 NCBI chr11:69,804,805...69,807,882
Ensembl chr11:69,804,714...69,807,417
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases activity ISO Malathion results in increased activity of GPT protein CTD PMID:25180440 PMID:36370973 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gramd4 GRAM domain containing 4 decreases expression ISO Malathion results in decreased expression of GRAMD4 mRNA CTD PMID:32069766 NCBI chr15:85,941,896...86,021,837
Ensembl chr15:85,941,896...86,021,835
JBrowse link
G Grk1 G protein-coupled receptor kinase 1 increases expression ISO Malathion results in increased expression of GRK1 mRNA CTD PMID:37047231 NCBI chr 8:13,455,081...13,471,951
Ensembl chr 8:13,455,081...13,471,951
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression ISO Malathion results in increased expression of GSK3B mRNA CTD PMID:25449180 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gsr glutathione reductase multiple interactions
decreases activity
EXP
ISO
[Hexachlorocyclohexane co-treated with Malathion] results in decreased activity of GSR protein
zinc chloride inhibits the reaction [Malathion results in decreased activity of GSR protein]
CTD PMID:16718366 PMID:19429256 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases expression ISO Malathion results in decreased expression of GSTP1 mRNA CTD PMID:32069766 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Gzmb granzyme B multiple interactions
decreases expression
EXP Plant Extracts inhibits the reaction [Malathion results in decreased expression of GZMB protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of GZMB protein] CTD PMID:32120800 NCBI chr14:56,496,293...56,499,791
Ensembl chr14:56,496,295...56,499,717
JBrowse link
G H19 H19, imprinted maternally expressed transcript increases expression ISO Malathion results in increased expression of H19 mRNA CTD PMID:37047231 NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917
JBrowse link
G H2-Q1 histocompatibility 2, Q region locus 1 decreases expression ISO Malathion results in decreased expression of HLA-A mRNA CTD PMID:32069766 NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075
JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 decreases expression ISO Malathion results in decreased expression of HLA-E mRNA CTD PMID:32069766 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747
JBrowse link
G Has1 hyaluronan synthase 1 increases expression ISO Malathion results in increased expression of HAS1 mRNA CTD PMID:37047231 NCBI chr17:18,063,588...18,075,450
Ensembl chr17:18,063,585...18,075,467
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Malathion results in increased expression of HBEGF mRNA CTD PMID:37047231 NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858
JBrowse link
G Hdc histidine decarboxylase affects binding ISO Malathion binds to [HDC protein binds to Pyridoxal Phosphate]; Malathion binds to HDC protein CTD PMID:35151785 NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219
JBrowse link
G Hilpda hypoxia inducible lipid droplet associated increases expression ISO Malathion results in increased expression of HILPDA mRNA CTD PMID:37047231 NCBI chr 6:29,272,487...29,275,448
Ensembl chr 6:29,272,487...29,275,445
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Malathion results in increased expression of HMOX1 protein CTD PMID:34778934 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnmt histamine N-methyltransferase decreases expression ISO Malathion results in decreased expression of HNMT mRNA CTD PMID:37047231 NCBI chr 2:23,892,923...23,939,756
Ensembl chr 2:23,892,922...23,939,406
JBrowse link
G Hras Harvey rat sarcoma virus oncogene multiple interactions
increases expression
ISO [Malathion co-treated with Estrogens] results in increased expression of HRAS mRNA
Malathion results in increased expression of HRAS mRNA; Malathion results in increased expression of HRAS protein
CTD PMID:18204794 PMID:19787260 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression
multiple interactions
EXP
ISO
Malathion results in decreased expression of HSD17B3 mRNA
lavender oil inhibits the reaction [Malathion results in decreased expression of HSD17B3 mRNA]
CTD PMID:30409133 PMID:36336997 NCBI chr13:64,206,088...64,237,076
Ensembl chr13:64,206,080...64,237,044
JBrowse link
G Hsf2bp heat shock transcription factor 2 binding protein increases expression ISO Malathion results in increased expression of HSF2BP mRNA CTD PMID:37047231 NCBI chr17:32,163,743...32,253,869
Ensembl chr17:32,163,743...32,255,323
JBrowse link
G Hspb2 heat shock protein 2 increases expression ISO Malathion results in increased expression of HSPB2 protein CTD PMID:19607909 NCBI chr 9:50,662,372...50,663,654
Ensembl chr 9:50,662,378...50,663,654
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 decreases expression ISO Malathion results in decreased expression of HTATIP2 mRNA CTD PMID:32069766 NCBI chr 7:49,408,761...49,423,748
Ensembl chr 7:49,408,863...49,423,723
JBrowse link
G Htra4 HtrA serine peptidase 4 decreases expression ISO Malathion results in decreased expression of HTRA4 mRNA CTD PMID:37047231 NCBI chr 8:25,514,944...25,529,160
Ensembl chr 8:25,514,945...25,528,978
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression ISO Malathion results in increased expression of IDO1 mRNA CTD PMID:37047231 NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025
JBrowse link
G Ifi44l interferon-induced protein 44 like increases expression ISO Malathion results in increased expression of IFI44L mRNA CTD PMID:37047231 NCBI chr 3:151,464,374...151,468,528
Ensembl chr 3:151,464,374...151,468,529
JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP Malathion inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
increases expression
ISO
EXP
Malathion results in decreased expression of IFNG protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IFNG protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IFNG protein]
Malathion results in increased expression of IFNG mRNA
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]
CTD PMID:19145326 PMID:24810974 PMID:25180440 PMID:28987951 PMID:32120800 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il11 interleukin 11 increases expression ISO Malathion results in increased expression of IL11 mRNA CTD PMID:37047231 NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858
JBrowse link
G Il13 interleukin 13 increases expression ISO Malathion results in increased expression of IL13 mRNA CTD PMID:37047231 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il13ra2 interleukin 13 receptor, alpha 2 increases expression ISO Malathion results in increased expression of IL13RA2 mRNA CTD PMID:32069766 NCBI chr  X:146,166,474...146,214,982
Ensembl chr  X:146,166,472...146,212,188
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Malathion results in increased expression of IL1A mRNA CTD PMID:37047231 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IL1B mRNA] CTD PMID:24810974 PMID:25180440 PMID:28987951 PMID:37047231 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il1r2 interleukin 1 receptor, type II decreases expression ISO Malathion results in decreased expression of IL1R2 mRNA CTD PMID:19784758 NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391
JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions
EXP Malathion results in decreased expression of IL2 protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL2 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL2 protein]
CTD PMID:32120800 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il23a interleukin 23, alpha subunit p19 increases expression ISO Malathion results in increased expression of IL23A mRNA CTD PMID:37047231 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621
JBrowse link
G Il24 interleukin 24 increases expression ISO Malathion results in increased expression of IL24 mRNA CTD PMID:37047231 NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
JBrowse link
G Il36g interleukin 36G increases expression ISO Malathion results in increased expression of IL36G mRNA CTD PMID:37047231 NCBI chr 2:24,076,488...24,083,579
Ensembl chr 2:24,076,488...24,083,580
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
EXP Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL4 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL4 protein] CTD PMID:32120800 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL6 mRNA] CTD PMID:24810974 PMID:25180440 PMID:37047231 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Inhba inhibin beta-A decreases methylation
increases expression
ISO Malathion results in decreased methylation of INHBA promoter
Malathion results in increased expression of INHBA mRNA
CTD PMID:37047231 NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206
JBrowse link
G Ins1 insulin I increases expression ISO Malathion results in increased expression of INS1 protein CTD PMID:25449180 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 increases expression ISO Malathion results in increased expression of IRAK1 mRNA CTD PMID:32069766 NCBI chr  X:73,057,520...73,067,527
Ensembl chr  X:73,057,520...73,067,524
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 increases expression ISO Malathion results in increased expression of IRAK2 mRNA CTD PMID:37047231 NCBI chr 6:113,615,428...113,671,987
Ensembl chr 6:113,615,428...113,671,987
JBrowse link
G Irx2 Iroquois homeobox 2 increases expression ISO Malathion results in increased expression of IRX2 mRNA CTD PMID:37047231 NCBI chr13:72,771,463...72,782,315
Ensembl chr13:72,776,939...72,782,317
JBrowse link
G Itgb8 integrin beta 8 decreases methylation
increases expression
ISO Malathion results in decreased methylation of ITGB8 promoter
Malathion results in increased expression of ITGB8 mRNA
CTD PMID:37047231 NCBI chr12:119,121,757...119,202,891
Ensembl chr12:119,121,757...119,202,537
JBrowse link
G Kazn kazrin, periplakin interacting protein decreases expression ISO Malathion results in decreased expression of KAZN mRNA CTD PMID:37047231 NCBI chr 4:141,829,701...142,801,231
Ensembl chr 4:141,829,701...142,205,056
JBrowse link
G Kcnh5 potassium voltage-gated channel, subfamily H (eag-related), member 5 increases expression ISO Malathion results in increased expression of KCNH5 mRNA CTD PMID:37047231 NCBI chr12:74,943,991...75,224,625
Ensembl chr12:74,943,994...75,224,106
JBrowse link
G Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 decreases expression
increases methylation
ISO Malathion results in decreased expression of KCNMA1 mRNA
Malathion results in increased methylation of KCNMA1 promoter
CTD PMID:37047231 NCBI chr14:23,342,356...24,055,173
Ensembl chr14:23,339,499...24,064,559
JBrowse link
G Kif6 kinesin family member 6 decreases expression ISO Malathion results in decreased expression of KIF6 mRNA CTD PMID:37047231 NCBI chr17:49,922,121...50,216,875
Ensembl chr17:49,922,164...50,216,875
JBrowse link
G Kmt2a lysine (K)-specific methyltransferase 2A increases expression
increases mutagenesis
ISO Malathion results in increased expression of KMT2A mRNA mutant form
Malathion results in increased mutagenesis of KMT2A gene
CTD PMID:28624474 NCBI chr 9:44,714,652...44,793,492
Ensembl chr 9:44,714,652...44,792,594
JBrowse link
G Krt14 keratin 14 increases expression ISO Malathion results in increased expression of KRT14 mRNA CTD PMID:37047231 NCBI chr11:100,093,988...100,098,336
Ensembl chr11:100,093,988...100,098,374
JBrowse link
G Krt17 keratin 17 increases expression ISO Malathion results in increased expression of KRT17 mRNA CTD PMID:37047231 NCBI chr11:100,147,041...100,151,855
Ensembl chr11:100,147,043...100,151,855
JBrowse link
G Krtap27-1 keratin associated protein 27-1 increases expression ISO Malathion results in increased expression of KRTAP27-1 mRNA CTD PMID:37047231 NCBI chr16:88,467,934...88,468,612
Ensembl chr16:88,467,914...88,468,559
JBrowse link
G L1td1 LINE-1 type transposase domain containing 1 multiple interactions
affects expression
increases methylation
ISO [Malathion results in increased methylation of L1TD1 promoter] which affects the expression of L1TD1 mRNA
Malathion affects the expression of L1TD1 mRNA
CTD PMID:36370973 NCBI chr 4:98,614,991...98,626,723
Ensembl chr 4:98,614,971...98,626,717
JBrowse link
G Lat linker for activation of T cells increases expression ISO Malathion results in increased expression of LAT mRNA CTD PMID:19784758 NCBI chr 7:125,962,999...125,968,877
Ensembl chr 7:125,962,996...125,968,742
JBrowse link
G Lcorl ligand dependent nuclear receptor corepressor-like increases expression ISO Malathion results in increased expression of LCORL mRNA CTD PMID:37047231 NCBI chr 5:45,854,523...46,015,213
NCBI chr 5:45,877,009...45,884,920
Ensembl chr 5:45,854,523...46,014,957
JBrowse link
G Lelp1 late cornified envelope-like proline-rich 1 decreases expression ISO Malathion results in decreased expression of LELP1 mRNA CTD PMID:37047231 NCBI chr 3:92,042,301...92,050,061
Ensembl chr 3:92,042,304...92,050,051
JBrowse link
G Lemd1 LEM domain containing 1 increases expression ISO Malathion results in increased expression of LEMD1 mRNA CTD PMID:37047231 NCBI chr 1:132,118,361...132,185,120
Ensembl chr 1:132,119,169...132,186,965
JBrowse link
G Lgals1 lectin, galactose binding, soluble 1 decreases expression ISO Malathion results in decreased expression of LGALS1 mRNA CTD PMID:32069766 NCBI chr15:78,810,925...78,814,665
Ensembl chr15:78,810,925...78,814,665
JBrowse link
G Lif leukemia inhibitory factor increases expression ISO Malathion results in increased expression of LIF mRNA CTD PMID:37047231 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514
JBrowse link
G Lin28b lin-28 homolog B increases expression ISO Malathion results in increased expression of LIN28B mRNA CTD PMID:37047231 NCBI chr10:45,252,713...45,362,410
Ensembl chr10:45,252,716...45,362,491
JBrowse link
G Lingo1 leucine rich repeat and Ig domain containing 1 decreases expression ISO Malathion results in decreased expression of LINGO1 mRNA CTD PMID:37047231 NCBI chr 9:56,525,743...56,704,355
Ensembl chr 9:56,525,759...56,703,752
JBrowse link
G Lmbr1 limb region 1 increases expression ISO Malathion results in increased expression of LMBR1 mRNA CTD PMID:37047231 NCBI chr 5:29,434,800...29,583,414
Ensembl chr 5:29,481,000...29,485,295
Ensembl chr 5:29,481,000...29,485,295
JBrowse link
G Lpcat4 lysophosphatidylcholine acyltransferase 4 increases expression ISO Malathion results in increased expression of LPCAT4 mRNA CTD PMID:32069766 NCBI chr 2:112,070,186...112,077,456
Ensembl chr 2:112,069,813...112,077,456
JBrowse link
G Lrguk leucine-rich repeats and guanylate kinase domain containing decreases expression ISO Malathion results in decreased expression of LRGUK mRNA CTD PMID:37047231 NCBI chr 6:34,006,183...34,110,969
Ensembl chr 6:34,006,379...34,110,969
JBrowse link
G Lrp3 low density lipoprotein receptor-related protein 3 decreases expression ISO Malathion results in decreased expression of LRP3 mRNA CTD PMID:37047231 NCBI chr 7:34,900,303...34,914,770
Ensembl chr 7:34,899,452...34,914,923
JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 decreases expression ISO Malathion results in decreased expression of LYPD1 mRNA CTD PMID:37047231 NCBI chr 1:125,795,359...125,841,134
Ensembl chr 1:125,795,359...125,840,838
JBrowse link
G Lzts1 leucine zipper, putative tumor suppressor 1 increases expression ISO Malathion results in increased expression of LZTS1 mRNA CTD PMID:37047231 NCBI chr 8:69,585,311...69,636,901
Ensembl chr 8:69,585,321...69,636,877
JBrowse link
G Lzts2 leucine zipper, putative tumor suppressor 2 decreases expression ISO Malathion results in decreased expression of LZTS2 mRNA CTD PMID:32069766 NCBI chr19:45,003,615...45,015,554
Ensembl chr19:45,002,853...45,015,550
JBrowse link
G Macrod2 mono-ADP ribosylhydrolase 2 decreases expression ISO Malathion results in decreased expression of MACROD2 mRNA CTD PMID:37047231 NCBI chr 2:140,237,223...142,234,886
Ensembl chr 2:140,237,229...142,234,886
JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 decreases expression ISO Malathion results in decreased expression of MAP2K3 mRNA CTD PMID:32069766 NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637
JBrowse link
G Marchf3 membrane associated ring-CH-type finger 3 increases expression ISO Malathion results in increased expression of MARCHF3 mRNA CTD PMID:37047231 NCBI chr18:56,894,788...57,058,587
Ensembl chr18:56,894,788...57,058,620
JBrowse link
G Mbp myelin basic protein decreases expression ISO Malathion results in decreased expression of MBP mRNA CTD PMID:37047231 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions
increases expression
ISO [Malathion co-treated with Estrogens] results in increased expression of MCM2 mRNA
Malathion results in increased expression of MCM2 mRNA
CTD PMID:18204794 NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762
JBrowse link
G Meis1 Meis homeobox 1 decreases expression ISO Malathion results in decreased expression of MEIS1 mRNA CTD PMID:37047231 NCBI chr11:18,830,428...18,968,992
Ensembl chr11:18,829,817...18,968,985
JBrowse link
G Met met proto-oncogene increases expression ISO Malathion results in increased expression of MET mRNA CTD PMID:37047231 NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid increases expression ISO Malathion results in increased expression of MFSD2A mRNA CTD PMID:37047231 NCBI chr 4:122,840,643...122,855,844
Ensembl chr 4:122,840,643...122,854,981
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO Malathion results in increased expression of MMP10 mRNA CTD PMID:37047231 NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression ISO Malathion results in increased expression of MMP12 mRNA CTD PMID:37047231 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) increases expression ISO Malathion results in increased expression of MMP1 mRNA CTD PMID:37047231 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO Malathion results in increased expression of MMP3 mRNA CTD PMID:37047231 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [Malathion results in increased activity of MPO protein] CTD PMID:24810974 PMID:25180440 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial decreases expression EXP Malathion results in decreased expression of COX1 mRNA CTD PMID:18214912 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
JBrowse link
G mt-Co3 cytochrome c oxidase III, mitochondrial decreases expression EXP Malathion results in decreased expression of COX3 mRNA CTD PMID:18214912 NCBI chr MT:8,607...9,390
Ensembl chr MT:8,607...9,390
JBrowse link
G Mt2 metallothionein 2 increases expression ISO Malathion results in increased expression of MT2A mRNA CTD PMID:37047231 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
JBrowse link
G Mybphl myosin binding protein H-like increases expression ISO Malathion results in increased expression of MYBPHL mRNA CTD PMID:37047231 NCBI chr 3:108,272,227...108,287,373
Ensembl chr 3:108,272,227...108,287,373
JBrowse link
G Myo1b myosin IB increases expression ISO Malathion results in increased expression of MYO1B mRNA CTD PMID:37047231 NCBI chr 1:51,788,915...51,955,143
Ensembl chr 1:51,788,924...51,955,230
JBrowse link
G Myzap myocardial zonula adherens protein increases expression ISO Malathion results in increased expression of MYZAP mRNA CTD PMID:37047231 NCBI chr 9:71,411,629...71,499,642
Ensembl chr 9:71,411,629...71,499,642
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 decreases expression ISO Malathion results in decreased expression of NDUFS7 mRNA CTD PMID:37047231 NCBI chr10:80,084,939...80,092,628
Ensembl chr10:80,084,955...80,092,628
JBrowse link
G Nefh neurofilament, heavy polypeptide affects expression
increases expression
ISO Malathion affects the expression of NEFH mRNA
Malathion results in increased expression of NEFH mRNA
CTD PMID:22954530 PMID:28385489 NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064
JBrowse link
G Nek10 NIMA (never in mitosis gene a)- related kinase 10 decreases expression ISO Malathion results in decreased expression of NEK10 mRNA CTD PMID:37047231 NCBI chr14:7,457,704...7,666,183
Ensembl chr14:7,457,704...7,666,348
JBrowse link
G Neu4 sialidase 4 increases expression ISO Malathion results in increased expression of NEU4 mRNA CTD PMID:37047231 NCBI chr 1:93,948,215...93,956,056
Ensembl chr 1:93,948,173...93,956,056
JBrowse link
G Neurl3 neuralized E3 ubiquitin protein ligase 3 increases expression ISO Malathion results in increased expression of NEURL3 mRNA CTD PMID:37047231 NCBI chr 1:36,303,683...36,313,755
Ensembl chr 1:36,303,678...36,313,760
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases activity EXP Malathion results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfib nuclear factor I/B decreases expression ISO Malathion results in decreased expression of NFIB mRNA CTD PMID:37047231 NCBI chr 4:82,208,410...82,424,988
Ensembl chr 4:82,208,410...82,623,987
JBrowse link
G Ngf nerve growth factor multiple interactions ISO Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA] CTD PMID:28385489 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Ninj1 ninjurin 1 decreases expression ISO Malathion results in decreased expression of NINJ1 mRNA CTD PMID:32069766 NCBI chr13:49,341,005...49,349,727
Ensembl chr13:49,340,961...49,349,720
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Malathion results in decreased expression of NNT mRNA CTD PMID:37047231 NCBI chr13:119,472,063...119,545,793
Ensembl chr13:119,471,984...119,545,533
Ensembl chr13:119,471,984...119,545,533
JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression ISO Malathion results in increased expression of NOS2 mRNA CTD PMID:20233601 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression EXP Malathion results in increased expression of NQO1 mRNA CTD PMID:17311802 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
increases activity
ISO
EXP
Malathion results in increased expression of NR1I3 mRNA
Malathion results in increased activity of NR1I3 protein
CTD PMID:22310298 PMID:28927721 PMID:30203046 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Malathion results in increased expression of NR4A1 mRNA CTD PMID:37047231 NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression
decreases methylation
ISO Malathion results in increased expression of NR4A3 mRNA
Malathion results in decreased methylation of NR4A3 promoter
CTD PMID:37047231 NCBI chr 4:48,045,098...48,086,446
Ensembl chr 4:48,045,153...48,086,447
JBrowse link
G Ntn1 netrin 1 increases expression ISO Malathion results in increased expression of NTN1 mRNA CTD PMID:37047231 NCBI chr11:68,100,190...68,277,652
Ensembl chr11:68,100,190...68,291,649
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 increases expression ISO Malathion results in increased expression of NTRK2 mRNA CTD PMID:32069766 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784
JBrowse link
G Ocln occludin multiple interactions
decreases expression
ISO [Malathion co-treated with Lead] results in decreased expression of OCLN protein
Malathion results in decreased expression of OCLN protein
CTD PMID:20970449 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226
JBrowse link
G Ocstamp osteoclast stimulatory transmembrane protein increases expression ISO Malathion results in increased expression of OCSTAMP mRNA CTD PMID:37047231 NCBI chr 2:165,237,370...165,242,314
Ensembl chr 2:165,235,680...165,242,325
JBrowse link
G Odam odontogenic, ameloblast asssociated decreases expression ISO Malathion results in decreased expression of ODAM mRNA CTD PMID:37047231 NCBI chr 5:88,032,869...88,042,668
Ensembl chr 5:88,032,888...88,042,033
JBrowse link
G Odf2l outer dense fiber of sperm tails 2-like decreases expression ISO Malathion results in decreased expression of ODF2L mRNA CTD PMID:37047231 NCBI chr 3:144,824,330...144,859,676
Ensembl chr 3:144,824,349...144,859,676
JBrowse link
G Omg oligodendrocyte myelin glycoprotein affects expression ISO Malathion affects the expression of OMG mRNA CTD PMID:37047231 NCBI chr11:79,391,808...79,394,908
Ensembl chr11:79,391,808...79,394,910
JBrowse link
G Opn5 opsin 5 decreases expression ISO Malathion results in decreased expression of OPN5 mRNA CTD PMID:37047231 NCBI chr17:42,867,670...42,922,321
Ensembl chr17:42,867,674...42,922,286
JBrowse link
G Or2at4 olfactory receptor family 2 subfamily AT member 4 decreases expression ISO Malathion results in decreased expression of OR2AT4 mRNA CTD PMID:37047231 NCBI chr 7:99,384,352...99,385,302
Ensembl chr 7:99,379,480...99,385,606
JBrowse link
G Or2w3 olfactory receptor family 2 subfamily W member 3 increases expression ISO Malathion results in increased expression of OR2W3 mRNA CTD PMID:37047231 NCBI chr11:58,556,387...58,557,370
Ensembl chr11:58,549,608...58,560,354
JBrowse link
G Or4d1 olfactory receptor family 4 subfamily D member 1 decreases expression ISO Malathion results in decreased expression of OR4D1 mRNA CTD PMID:37047231 NCBI chr11:87,804,746...87,805,829
Ensembl chr11:87,804,094...87,811,793
JBrowse link
G Or4f7 olfactory receptor family 4 subfamily F member 7 decreases expression ISO Malathion results in decreased expression of OR4F29 mRNA CTD PMID:37047231 NCBI chr 2:111,644,131...111,645,069
Ensembl chr 2:111,642,592...111,650,685
JBrowse link
G Or6c2 olfactory receptor family 6 subfamily C member 2 decreases expression ISO Malathion results in decreased expression of OR6C2 mRNA CTD PMID:37047231 NCBI chr10:129,362,098...129,363,036
Ensembl chr10:129,357,661...129,364,222
JBrowse link
G Or9g4 olfactory receptor family 9 subfamily G member 4 decreases expression ISO Malathion results in decreased expression of OR9G4 mRNA CTD PMID:37047231 NCBI chr 2:85,504,555...85,509,085
Ensembl chr 2:85,504,001...85,509,111
JBrowse link
G P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 increases expression ISO Malathion results in increased expression of P2RX1 mRNA CTD PMID:19784758 NCBI chr11:72,889,882...72,906,026
Ensembl chr11:72,889,929...72,906,026
JBrowse link
G Palmd palmdelphin decreases expression ISO Malathion results in decreased expression of PALMD mRNA CTD PMID:37047231 NCBI chr 3:116,711,911...116,762,896
Ensembl chr 3:116,711,907...116,762,636
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions
EXP Malathion results in increased cleavage of PARP1 protein
Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]
CTD PMID:29027213 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pax1 paired box 1 increases expression ISO Malathion results in increased expression of PAX1 mRNA CTD PMID:32069766 NCBI chr 2:147,203,850...147,216,972
Ensembl chr 2:147,203,845...147,235,215
JBrowse link
G Pcdh15 protocadherin 15 decreases expression ISO Malathion results in decreased expression of PCDH15 mRNA CTD PMID:37047231 NCBI chr10:72,932,003...74,485,663
Ensembl chr10:72,935,174...74,485,569
JBrowse link
G Pcdhb19 protocadherin beta 19 decreases expression ISO Malathion results in decreased expression of PCDHB12 mRNA CTD PMID:37047231 NCBI chr18:37,630,049...37,637,181
Ensembl chr18:37,630,044...37,637,181
JBrowse link
G Pcdhgb1 protocadherin gamma subfamily B, 1 increases expression ISO Malathion results in increased expression of PCDHGB1 mRNA CTD PMID:37047231 NCBI chr18:37,813,325...37,974,923
Ensembl chr18:37,813,286...37,974,923
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Malathion results in increased expression of PCK1 mRNA] CTD PMID:25449180 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO Atropine inhibits the reaction [Malathion results in increased expression of PCNA] CTD PMID:12762645 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pde6c phosphodiesterase 6C, cGMP specific, cone, alpha prime decreases expression ISO Malathion results in decreased expression of PDE6C mRNA CTD PMID:37047231 NCBI chr19:38,121,220...38,172,391
Ensembl chr19:38,121,229...38,172,406
JBrowse link
G Pdia2 protein disulfide isomerase associated 2 decreases expression ISO Malathion results in decreased expression of PDIA2 mRNA CTD PMID:37047231 NCBI chr17:26,414,973...26,418,108
Ensembl chr17:26,414,973...26,418,061
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 decreases expression ISO Malathion results in decreased expression of PEBP1 mRNA CTD PMID:32069766 NCBI chr 5:117,420,716...117,425,629
Ensembl chr 5:117,420,719...117,425,690
JBrowse link
G Peg10 paternally expressed 10 increases expression ISO Malathion results in increased expression of PEG10 mRNA CTD PMID:37047231 NCBI chr 6:4,747,306...4,760,517
Ensembl chr 6:4,747,306...4,760,517
JBrowse link
G Pfn1 profilin 1 decreases expression ISO Malathion results in decreased expression of PFN1 mRNA CTD PMID:32069766 NCBI chr11:70,542,670...70,547,625
Ensembl chr11:70,542,676...70,545,470
JBrowse link
G Phb1 prohibitin 1 decreases expression ISO Malathion results in decreased expression of PHB1 mRNA CTD PMID:32069766 NCBI chr11:95,557,783...95,571,599
Ensembl chr11:95,557,783...95,571,599
JBrowse link
G Pitx1 paired-like homeodomain transcription factor 1 decreases expression ISO Malathion results in decreased expression of PITX1 mRNA CTD PMID:37047231 NCBI chr13:55,972,857...55,984,002
Ensembl chr13:55,972,864...55,984,005
JBrowse link
G Plat plasminogen activator, tissue decreases expression ISO Malathion results in decreased expression of PLAT mRNA CTD PMID:16079077 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO Malathion results in increased expression of PLAU mRNA CTD PMID:32069766 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO Malathion results in increased expression of PLAUR mRNA CTD PMID:37047231 NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393
JBrowse link
G Plcb4 phospholipase C, beta 4 increases expression ISO Malathion results in increased expression of PLCB4 mRNA CTD PMID:37047231 NCBI chr 2:135,500,523...135,856,522
Ensembl chr 2:135,500,931...135,856,513
JBrowse link
G Plekhd1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 decreases expression ISO Malathion results in decreased expression of PLEKHD1 mRNA CTD PMID:37047231 NCBI chr12:80,739,375...80,770,990
Ensembl chr12:80,739,365...80,770,988
JBrowse link
G Plin1 perilipin 1 increases expression ISO Malathion results in increased expression of PLIN1 mRNA CTD PMID:37047231 NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651
JBrowse link
G Plin2 perilipin 2 increases expression ISO Malathion results in increased expression of PLIN2 mRNA CTD PMID:37047231 NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297
JBrowse link
G Plp1 proteolipid protein (myelin) 1 decreases expression ISO Malathion results in decreased expression of PLP1 mRNA CTD PMID:37047231 NCBI chr  X:135,720,897...135,739,331
Ensembl chr  X:135,723,420...135,740,482
JBrowse link
G Pls3 plastin 3 (T-isoform) increases expression ISO Malathion results in increased expression of PLS3 mRNA CTD PMID:37047231 NCBI chr  X:74,829,259...74,918,788
Ensembl chr  X:74,829,260...74,918,788
JBrowse link
G Plvap plasmalemma vesicle associated protein decreases expression ISO Malathion results in decreased expression of PLVAP mRNA CTD PMID:37047231 NCBI chr 8:71,950,397...71,964,446
Ensembl chr 8:71,950,409...71,964,396
JBrowse link
G Pml promyelocytic leukemia decreases expression ISO Malathion results in decreased expression of PML mRNA CTD PMID:32069766 NCBI chr 9:58,125,359...58,157,077
Ensembl chr 9:58,125,359...58,157,069
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Malathion results in decreased expression of PPARA mRNA CTD PMID:25689681 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Prkd1 protein kinase D1 increases expression ISO Malathion results in increased expression of PRKD1 mRNA CTD PMID:32069766 NCBI chr12:50,388,009...50,696,075
Ensembl chr12:50,388,014...50,695,881
JBrowse link
G Prox2 prospero homeobox 2 decreases expression ISO Malathion results in decreased expression of PROX2 mRNA CTD PMID:37047231 NCBI chr12:85,132,584...85,157,606
Ensembl chr12:85,133,159...85,157,533
JBrowse link
G Proz protein Z, vitamin K-dependent plasma glycoprotein decreases expression ISO Malathion results in decreased expression of PROZ mRNA CTD PMID:37047231 NCBI chr 8:13,110,583...13,126,026
Ensembl chr 8:13,110,914...13,126,026
JBrowse link
G Ptcra pre T cell antigen receptor alpha decreases expression ISO Malathion results in decreased expression of PTCRA mRNA CTD PMID:37047231 NCBI chr17:47,066,589...47,074,659
Ensembl chr17:47,066,589...47,074,638
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Malathion results in increased expression of PTGS2 mRNA; Malathion results in increased expression of PTGS2 protein CTD PMID:30673264 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Pygl liver glycogen phosphorylase multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Malathion results in increased expression of PYGL mRNA] CTD PMID:25449180 NCBI chr12:70,237,589...70,274,457
Ensembl chr12:70,237,585...70,278,262
JBrowse link
G Rab11fip3 RAB11 family interacting protein 3 (class II) increases expression ISO Malathion results in increased expression of RAB11FIP3 mRNA CTD PMID:32069766 NCBI chr17:26,208,010...26,289,010
Ensembl chr17:26,208,010...26,288,529
JBrowse link
G Rab3c RAB3C, member RAS oncogene family decreases expression ISO Malathion results in decreased expression of RAB3C mRNA CTD PMID:37047231 NCBI chr13:110,190,721...110,417,530
Ensembl chr13:110,190,721...110,417,530
JBrowse link
G Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 increases expression ISO Malathion results in increased expression of RAPGEF5 mRNA CTD PMID:37047231 NCBI chr12:117,480,146...117,723,472
Ensembl chr12:117,480,099...117,723,472
JBrowse link
G Rbp3 retinol binding protein 3, interstitial decreases expression ISO Malathion results in decreased expression of RBP3 mRNA CTD PMID:37047231 NCBI chr14:33,675,960...33,686,176
Ensembl chr14:33,675,960...33,686,173
JBrowse link
G Rbp7 retinol binding protein 7, cellular decreases expression ISO Malathion results in decreased expression of RBP7 mRNA CTD PMID:37047231 NCBI chr 4:149,534,144...149,550,919
Ensembl chr 4:149,534,144...149,539,435
JBrowse link
G Redic1 regulator of DNA class I crossover intermediates 1 decreases expression ISO Malathion results in decreased expression of REDIC1 mRNA CTD PMID:37047231 NCBI chr15:91,083,654...91,146,291
Ensembl chr15:91,083,697...91,145,097
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases expression
multiple interactions
ISO Malathion results in increased expression of RELA mRNA
Taurine inhibits the reaction [Malathion results in increased expression of RELA mRNA]
CTD PMID:28987951 PMID:30673264 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Reln reelin increases expression ISO Malathion results in increased expression of RELN mRNA CTD PMID:37047231 NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700
JBrowse link
G Rfc3 replication factor C (activator 1) 3 decreases expression ISO Malathion results in decreased expression of RFC3 mRNA CTD PMID:16079077 NCBI chr 5:151,566,282...151,574,673
Ensembl chr 5:151,566,221...151,574,707
JBrowse link
G Rft1 RFT1 homolog decreases expression ISO Malathion results in decreased expression of RFT1 mRNA CTD PMID:37047231 NCBI chr14:30,375,041...30,413,274
Ensembl chr14:30,376,317...30,413,274
JBrowse link
G Rhoa ras homolog family member A decreases activity EXP Malathion results in decreased activity of RHOA protein CTD PMID:37270087 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Rhox13 reproductive homeobox 13 increases expression ISO Malathion results in increased expression of RHOXF1 mRNA CTD PMID:37047231 NCBI chr  X:37,210,059...37,218,850
Ensembl chr  X:37,210,096...37,218,844
JBrowse link
G Rimbp2 RIMS binding protein 2 decreases expression ISO Malathion results in decreased expression of RIMBP2 mRNA CTD PMID:37047231 NCBI chr 5:128,834,852...129,030,636
Ensembl chr 5:128,834,855...129,030,550
JBrowse link
G Rnase6 ribonuclease, RNase A family, 6 increases expression ISO Malathion results in increased expression of RNASE6 mRNA CTD PMID:19784758 NCBI chr14:51,361,365...51,369,644
Ensembl chr14:51,361,365...51,369,644
JBrowse link
G Rnf170 ring finger protein 170 increases expression ISO Malathion results in increased expression of RNF170 mRNA CTD PMID:37047231 NCBI chr 8:26,609,396...26,633,903
Ensembl chr 8:26,609,396...26,641,818
JBrowse link
G Rnf183 ring finger protein 183 increases expression ISO Malathion results in increased expression of RNF183 mRNA CTD PMID:37047231 NCBI chr 4:62,345,777...62,353,487
Ensembl chr 4:62,345,777...62,353,489
JBrowse link
G Robo4 roundabout guidance receptor 4 decreases expression ISO Malathion results in decreased expression of ROBO4 mRNA CTD PMID:37047231 NCBI chr 9:37,313,198...37,325,319
Ensembl chr 9:37,313,193...37,326,411
JBrowse link
G Rph3a rabphilin 3A decreases expression ISO Malathion results in decreased expression of RPH3A mRNA CTD PMID:37047231 NCBI chr 5:121,078,562...121,184,249
Ensembl chr 5:121,078,562...121,148,155
JBrowse link
G Rrad Ras-related associated with diabetes increases expression ISO Malathion results in increased expression of RRAD mRNA CTD PMID:37047231 NCBI chr 8:105,354,702...105,357,921
Ensembl chr 8:105,354,702...105,357,959
JBrowse link
G Rs1 retinoschisis (X-linked, juvenile) 1 (human) increases expression ISO Malathion results in increased expression of RS1 mRNA CTD PMID:37047231 NCBI chr  X:159,548,815...159,584,800
Ensembl chr  X:159,551,009...159,582,659
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 increases expression ISO Malathion results in increased expression of RSAD2 mRNA CTD PMID:37047231 NCBI chr12:26,492,742...26,506,451
Ensembl chr12:26,492,745...26,506,451
JBrowse link
G Rspo2 R-spondin 2 decreases expression ISO Malathion results in decreased expression of RSPO2 mRNA CTD PMID:37047231 NCBI chr15:42,884,184...43,034,990
Ensembl chr15:42,884,190...43,034,222
JBrowse link
G Runx1 runt related transcription factor 1 increases expression ISO Malathion results in increased expression of RUNX1 mRNA mutant form CTD PMID:28624474 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037
JBrowse link
G S100a1 S100 calcium binding protein A1 decreases expression ISO Malathion results in decreased expression of S100A1 mRNA CTD PMID:37047231 NCBI chr 3:90,418,341...90,421,637
Ensembl chr 3:90,418,341...90,421,699
JBrowse link
G Scg5 secretogranin V increases expression ISO Malathion results in increased expression of SCG5 mRNA CTD PMID:37047231 NCBI chr 2:113,606,708...113,659,423
Ensembl chr 2:113,606,707...113,659,466
JBrowse link
G Scn9a sodium channel, voltage-gated, type IX, alpha decreases expression ISO Malathion results in decreased expression of SCN9A mRNA CTD PMID:37047231 NCBI chr 2:66,310,424...66,465,456
Ensembl chr 2:66,310,424...66,465,306
JBrowse link
G Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 increases expression ISO Malathion results in increased expression of SERPINB2 mRNA CTD PMID:37047231 NCBI chr 1:107,439,153...107,453,330
Ensembl chr 1:107,439,153...107,463,208
JBrowse link
G Sftpb surfactant associated protein B decreases expression ISO Malathion results in decreased expression of SFTPB mRNA CTD PMID:37047231 NCBI chr 6:72,281,594...72,291,354
Ensembl chr 6:72,281,594...72,291,354
JBrowse link
G Sgpp2 sphingosine-1-phosphate phosphatase 2 increases expression ISO Malathion results in increased expression of SGPP2 mRNA CTD PMID:37047231 NCBI chr 1:78,286,186...78,396,926
Ensembl chr 1:78,286,982...78,396,926
JBrowse link
G Shc1 src homology 2 domain-containing transforming protein C1 increases expression ISO Malathion results in increased expression of SHC1 mRNA CTD PMID:32069766 NCBI chr 3:89,325,858...89,337,336
Ensembl chr 3:89,325,750...89,337,334
JBrowse link
G Shisa3 shisa family member 3 increases expression ISO Malathion results in increased expression of SHISA3 mRNA CTD PMID:37047231 NCBI chr 5:67,765,226...67,771,330
Ensembl chr 5:67,765,225...67,780,895
JBrowse link
G Shisa9 shisa family member 9 increases expression ISO Malathion results in increased expression of SHISA9 mRNA CTD PMID:37047231 NCBI chr16:11,801,457...12,088,768
Ensembl chr16:11,801,977...12,088,766
JBrowse link
G Shtn1 shootin 1 decreases expression ISO Malathion results in decreased expression of SHTN1 mRNA CTD PMID:37047231 NCBI chr19:58,961,790...59,064,536
Ensembl chr19:58,961,788...59,064,532
JBrowse link
G Slc14a1 solute carrier family 14 (urea transporter), member 1 decreases expression ISO Malathion results in decreased expression of SLC14A1 mRNA CTD PMID:37047231 NCBI chr18:78,143,306...78,185,334
Ensembl chr18:78,143,306...78,185,334
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Malathion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 multiple interactions ISO Malathion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663
JBrowse link
G Slc4a5 solute carrier family 4, sodium bicarbonate cotransporter, member 5 decreases expression ISO Malathion results in decreased expression of SLC4A5 mRNA CTD PMID:37047231 NCBI chr 6:83,184,561...83,281,927
Ensembl chr 6:83,196,810...83,281,927
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 increases expression ISO Malathion results in increased expression of SLCO4A1 mRNA CTD PMID:37047231 NCBI chr 2:180,098,019...180,116,646
Ensembl chr 2:180,098,038...180,116,660
JBrowse link
G Smim32 small integral membrane protein 32 decreases expression ISO Malathion results in decreased expression of SMIM32 mRNA CTD PMID:37047231 NCBI chr13:56,897,857...56,901,640
Ensembl chr13:56,900,184...56,901,640
JBrowse link
G Snca synuclein, alpha increases expression
multiple interactions
ISO Malathion results in increased expression of SNCA mRNA; Malathion results in increased expression of SNCA protein
crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein]; Levodopa inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; Levodopa inhibits the reaction [Malathion results in increased expression of SNCA protein]
CTD PMID:35274200 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Sntg1 syntrophin, gamma 1 decreases expression ISO Malathion results in decreased expression of SNTG1 mRNA CTD PMID:37047231 NCBI chr 1:8,429,963...9,371,882
Ensembl chr 1:8,431,699...9,370,103
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO Malathion results in decreased expression of SOCS3 mRNA CTD PMID:32069766 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases activity
decreases expression
multiple interactions
ISO
EXP
Malathion results in increased activity of SOD1 protein
Malathion results in decreased expression of SOD1 protein
lavender oil inhibits the reaction [Malathion results in decreased expression of SOD1 protein]
alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD1 protein]
CTD PMID:20194575 PMID:30409133 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
decreases expression
ISO
EXP
alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD2 protein]; Malathion results in increased expression of and results in increased activity of SOD2 protein
Malathion results in decreased expression of SOD2 protein
lavender oil inhibits the reaction [Malathion results in decreased expression of SOD2 protein]
CTD PMID:20194575 PMID:30409133 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Spata17 spermatogenesis associated 17 decreases expression ISO Malathion results in decreased expression of SPATA17 mRNA CTD PMID:37047231 NCBI chr 1:186,741,811...186,947,705
Ensembl chr 1:186,776,845...186,947,662
JBrowse link
G Spdya speedy/RINGO cell cycle regulator family, member A increases expression ISO Malathion results in increased expression of SPDYA mRNA CTD PMID:37047231 NCBI chr17:71,833,890...71,896,528
Ensembl chr17:71,859,056...71,896,528
JBrowse link
G Spink13 serine peptidase inhibitor, Kazal type 13 decreases expression ISO Malathion results in decreased expression of SPINK13 mRNA CTD PMID:37047231 NCBI chr18:62,740,570...62,874,458
Ensembl chr18:62,740,606...62,874,458
JBrowse link
G Spink4 serine peptidase inhibitor, Kazal type 4 decreases expression ISO Malathion results in decreased expression of SPINK4 mRNA CTD PMID:37047231 NCBI chr 4:40,920,056...40,931,395
Ensembl chr 4:40,920,052...40,931,395
JBrowse link
G Srsf5 serine and arginine-rich splicing factor 5 decreases expression ISO Malathion results in decreased expression of SRSF5 mRNA CTD PMID:19784758 NCBI chr12:80,992,308...80,997,277
Ensembl chr12:80,992,278...80,997,281
JBrowse link
G Sspo SCO-spondin decreases expression ISO Malathion results in decreased expression of SSPOP mRNA CTD PMID:37047231 NCBI chr 6:48,423,164...48,478,196
Ensembl chr 6:48,425,163...48,478,184
JBrowse link
G Sst somatostatin decreases expression ISO Malathion results in decreased expression of SST mRNA CTD PMID:37047231 NCBI chr16:23,708,327...23,710,041
Ensembl chr16:23,708,323...23,709,708
JBrowse link
G Sstr2 somatostatin receptor 2 increases expression ISO Malathion results in increased expression of SSTR2 mRNA CTD PMID:37047231 NCBI chr11:113,510,153...113,516,854
Ensembl chr11:113,510,168...113,516,854
JBrowse link
G St6gal2 beta galactoside alpha 2,6 sialyltransferase 2 increases expression ISO Malathion results in increased expression of ST6GAL2 mRNA CTD PMID:37047231 NCBI chr17:55,752,071...55,821,582
Ensembl chr17:55,752,383...55,821,582
JBrowse link
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 increases expression ISO Malathion results in increased expression of ST8SIA1 mRNA CTD PMID:19784758 NCBI chr 6:142,767,267...142,935,247
Ensembl chr 6:142,767,271...142,910,178
JBrowse link
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 increases expression ISO Malathion results in increased expression of ST8SIA4 mRNA CTD PMID:37047231 NCBI chr 1:95,515,407...95,595,473
Ensembl chr 1:95,515,407...95,595,296
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression
EXP lavender oil inhibits the reaction [Malathion results in decreased expression of STAR mRNA] CTD PMID:30409133 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Malathion results in decreased phosphorylation of STAT3 protein CTD PMID:34778934 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity EXP Malathion results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550
JBrowse link
G Stk36 serine/threonine kinase 36 decreases expression ISO Malathion results in decreased expression of STK36 mRNA CTD PMID:37047231 NCBI chr 1:74,640,583...74,676,053
Ensembl chr 1:74,640,604...74,676,053
JBrowse link
G Stra6 stimulated by retinoic acid gene 6 decreases expression ISO Malathion results in decreased expression of STRA6 mRNA CTD PMID:37047231 NCBI chr 9:57,971,076...58,061,287
Ensembl chr 9:57,971,071...58,061,279
JBrowse link
G Tcf7l1 transcription factor 7 like 1 (T cell specific, HMG box) increases expression ISO Malathion results in increased expression of TCF7L1 mRNA CTD PMID:37047231 NCBI chr 6:72,603,354...72,766,028
Ensembl chr 6:72,603,361...72,766,237
JBrowse link
G Tchhl1 trichohyalin-like 1 decreases expression ISO Malathion results in decreased expression of TCHHL1 mRNA CTD PMID:37047231 NCBI chr 3:93,376,061...93,379,287
Ensembl chr 3:93,376,061...93,379,287
JBrowse link
G Tdrd1 tudor domain containing 1 increases expression ISO Malathion results in increased expression of TDRD1 mRNA CTD PMID:37047231 NCBI chr19:56,814,603...56,858,444
Ensembl chr19:56,814,641...56,858,444
JBrowse link
G Tdrd6 tudor domain containing 6 increases expression ISO Malathion results in increased expression of TDRD6 mRNA CTD PMID:37047231 NCBI chr17:43,926,225...43,942,737
Ensembl chr17:43,926,226...43,941,190
JBrowse link
G Tdrp testis development related protein decreases expression ISO Malathion results in decreased expression of TDRP mRNA CTD PMID:37047231 NCBI chr 8:14,002,008...14,025,484
Ensembl chr 8:14,002,008...14,025,032
JBrowse link
G Tek TEK receptor tyrosine kinase increases expression ISO Malathion results in increased expression of TEK mRNA CTD PMID:32069766 NCBI chr 4:94,627,322...94,763,213
Ensembl chr 4:94,627,526...94,763,213
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 affects expression ISO Malathion affects the expression of TET1 mRNA CTD PMID:36370973 NCBI chr10:62,640,349...62,723,242
Ensembl chr10:62,640,349...62,744,775
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 decreases expression ISO Malathion results in decreased expression of TET2 mRNA CTD PMID:36370973 NCBI chr 3:133,169,438...133,250,882
Ensembl chr 3:133,169,440...133,250,900
JBrowse link
G Tet3 tet methylcytosine dioxygenase 3 affects expression ISO Malathion affects the expression of TET3 mRNA CTD PMID:36370973 NCBI chr 6:83,339,355...83,434,190
Ensembl chr 6:83,339,355...83,436,066
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 increases expression ISO Malathion results in increased expression of TFPI2 mRNA CTD PMID:37047231 NCBI chr 6:3,962,589...3,988,977
Ensembl chr 6:3,962,595...3,988,919
JBrowse link
G Tfrc transferrin receptor increases expression ISO Malathion results in increased expression of TFRC mRNA CTD PMID:32069766 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612
JBrowse link
G Tg thyroglobulin decreases expression ISO Malathion results in decreased expression of TG mRNA; Malathion results in decreased expression of TG protein CTD PMID:29143548 NCBI chr15:66,542,606...66,722,570
Ensembl chr15:66,542,602...66,722,570
JBrowse link
G Tifab TRAF-interacting protein with forkhead-associated domain, family member B decreases expression ISO Malathion results in decreased expression of TIFAB mRNA CTD PMID:37047231 NCBI chr13:56,318,917...56,326,816
Ensembl chr13:56,321,517...56,326,698
JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 decreases expression ISO Malathion results in decreased expression of TIMP3 mRNA CTD PMID:19784758 NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression
ISO [Malathion co-treated with Lead] results in decreased expression of TJP1 protein
Malathion results in decreased expression of TJP1 protein
CTD PMID:20970449 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
JBrowse link
G Tjp2 tight junction protein 2 multiple interactions
decreases expression
ISO [Malathion co-treated with Lead] results in decreased expression of TJP2 protein
Malathion results in decreased expression of TJP2 protein
CTD PMID:20970449 NCBI chr19:24,071,860...24,202,492
Ensembl chr19:24,071,869...24,202,394
JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions
EXP Malathion results in increased expression of TLR4 protein
Plant Extracts inhibits the reaction [Malathion results in increased expression of TLR4 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TLR4 protein]
CTD PMID:32120800 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tlr8 toll-like receptor 8 increases expression ISO Malathion results in increased expression of TLR8 mRNA CTD PMID:32069766 NCBI chr  X:166,024,119...166,047,325
Ensembl chr  X:166,025,692...166,047,325
JBrowse link
G Tmem114 transmembrane protein 114 decreases expression ISO Malathion results in decreased expression of TMEM114 mRNA CTD PMID:37047231 NCBI chr16:8,227,140...8,243,000
Ensembl chr16:8,227,139...8,243,000
JBrowse link
G Tmem158 transmembrane protein 158 increases expression ISO Malathion results in increased expression of TMEM158 mRNA CTD PMID:37047231 NCBI chr 9:123,088,122...123,089,854
Ensembl chr 9:123,088,118...123,089,829
JBrowse link
G Tmem241 transmembrane protein 241 decreases expression ISO Malathion results in decreased expression of TMEM241 mRNA CTD PMID:37047231 NCBI chr18:12,113,193...12,254,604
Ensembl chr18:12,097,507...12,254,594
JBrowse link
G Tmem65 transmembrane protein 65 increases expression ISO Malathion results in increased expression of TMEM65 mRNA CTD PMID:37047231 NCBI chr15:58,654,118...58,695,510
Ensembl chr15:58,654,118...58,695,487
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO Taurine inhibits the reaction [Malathion results in increased expression of TNF mRNA] CTD PMID:28987951 PMID:37047231 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 increases expression ISO Malathion results in increased expression of TNFAIP6 mRNA CTD PMID:37047231 NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698
JBrowse link
G Tnfaip8l3 tumor necrosis factor, alpha-induced protein 8-like 3 decreases expression ISO Malathion results in decreased expression of TNFAIP8L3 mRNA CTD PMID:37047231 NCBI chr 9:53,932,890...53,975,695
Ensembl chr 9:53,930,689...53,975,672
JBrowse link
G Tnfsf15 tumor necrosis factor (ligand) superfamily, member 15 affects expression ISO Malathion affects the expression of TNFSF15 mRNA CTD PMID:37047231 NCBI chr 4:63,642,837...63,663,296
Ensembl chr 4:63,642,840...63,663,350
JBrowse link
G Tnip3 TNFAIP3 interacting protein 3 increases expression ISO Malathion results in increased expression of TNIP3 mRNA CTD PMID:37047231 NCBI chr 6:65,567,382...65,611,024
Ensembl chr 6:65,502,297...65,611,024
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO Malathion results in increased expression of TPR mRNA CTD PMID:32069766 NCBI chr 1:150,268,544...150,325,686
Ensembl chr 1:150,268,589...150,325,686
JBrowse link
G Tram1l1 translocation associated membrane protein 1-like 1 increases expression ISO Malathion results in increased expression of TRAM1L1 mRNA CTD PMID:37047231 NCBI chr 3:124,114,686...124,116,909
Ensembl chr 3:124,114,504...124,118,392
JBrowse link
G Trim35 tripartite motif-containing 35 decreases expression ISO Malathion results in decreased expression of TRIM35 mRNA CTD PMID:32069766 NCBI chr14:66,534,474...66,548,873
Ensembl chr14:66,534,480...66,548,873
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression
ISO
EXP
Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]
Plant Extracts inhibits the reaction [Malathion results in increased expression of TRP53 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TRP53 protein]
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
Malathion results in increased expression of TP53 mRNA; Malathion results in increased expression of TP53 protein
CTD PMID:12505448 PMID:12762645 PMID:18204794 PMID:19787260 PMID:21628957 More... NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression ISO Malathion results in increased expression of TRPC1 mRNA; Malathion results in increased expression of TRPC1 protein CTD PMID:22674931 NCBI chr 9:95,587,125...95,632,438
Ensembl chr 9:95,587,135...95,632,428
JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 increases expression
decreases expression
ISO Malathion results in increased expression of TRPC4 mRNA; Malathion results in increased expression of TRPC4 protein
Malathion results in decreased expression of TRPC4 mRNA
CTD PMID:22674931 PMID:37047231 NCBI chr 3:54,063,441...54,225,892
Ensembl chr 3:54,063,456...54,225,892
JBrowse link
G Trpc5os transient receptor potential cation channel, subfamily C, member 5, opposite strand increases expression ISO Malathion results in increased expression of TRPC5OS mRNA CTD PMID:37047231 NCBI chr  X:143,238,872...143,260,059
Ensembl chr  X:143,239,577...143,260,062
JBrowse link
G Trpd52l3 tumor protein D52-like 3 decreases expression ISO Malathion results in decreased expression of TPD52L3 mRNA CTD PMID:37047231 NCBI chr19:29,981,190...29,983,420
Ensembl chr19:29,981,190...29,983,418
JBrowse link
G Tshr thyroid stimulating hormone receptor decreases expression ISO Malathion results in decreased expression of TSHR protein CTD PMID:29143548 NCBI chr12:91,367,767...91,507,283
Ensembl chr12:91,351,337...91,516,582
JBrowse link
G Ttc9 tetratricopeptide repeat domain 9 decreases expression ISO Malathion results in decreased expression of TTC9 mRNA CTD PMID:37047231 NCBI chr12:81,678,023...81,714,331
Ensembl chr12:81,678,023...81,714,331
JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator decreases expression ISO Malathion results in decreased expression of TUSC2 mRNA CTD PMID:32069766 NCBI chr 9:107,440,454...107,443,307
Ensembl chr 9:107,440,454...107,443,311
JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 increases expression ISO Malathion results in increased expression of TWIST1 mRNA CTD PMID:32069766 NCBI chr12:34,007,670...34,009,830
Ensembl chr12:34,007,670...34,009,828
JBrowse link
G Txnrd3 thioredoxin reductase 3 decreases expression ISO Malathion results in decreased expression of TXNRD3 mRNA CTD PMID:37047231 NCBI chr 6:89,620,970...89,652,511
Ensembl chr 6:89,620,970...89,652,511
JBrowse link
G Tyms thymidylate synthase decreases expression ISO Malathion results in decreased expression of TYMS mRNA CTD PMID:16079077 NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615
JBrowse link
G Ubd ubiquitin D increases expression ISO Malathion results in increased expression of UBD mRNA CTD PMID:37047231 NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986
JBrowse link
G Umodl1 uromodulin-like 1 increases expression ISO Malathion results in increased expression of UMODL1 mRNA CTD PMID:37047231 NCBI chr17:31,173,614...31,229,684
Ensembl chr17:31,173,614...31,229,684
JBrowse link
G Usp2 ubiquitin specific peptidase 2 increases expression ISO Malathion results in increased expression of USP2 mRNA CTD PMID:37047231 NCBI chr 9:43,978,318...44,006,924
Ensembl chr 9:43,978,318...44,006,924
JBrowse link
G Usp27x ubiquitin specific peptidase 27, X chromosome increases expression ISO Malathion results in increased expression of USP27X mRNA CTD PMID:37047231 NCBI chr  X:7,238,830...7,242,069
Ensembl chr  X:7,237,513...7,242,069
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor decreases expression ISO Malathion results in decreased expression of VHL mRNA CTD PMID:32069766 NCBI chr 6:113,600,955...113,608,595
Ensembl chr 6:113,600,920...113,608,594
JBrowse link
G Vpreb3 V-set pre-B cell surrogate light chain 3 increases expression ISO Malathion results in increased expression of VPREB3 mRNA CTD PMID:32069766 NCBI chr10:75,778,859...75,785,491
Ensembl chr10:75,778,891...75,785,491
JBrowse link
G Wbp2nl WBP2 N-terminal like decreases expression ISO Malathion results in decreased expression of WBP2NL mRNA CTD PMID:37047231 NCBI chr15:82,183,126...82,198,848
Ensembl chr15:82,183,155...82,198,824
JBrowse link
G Wfdc6a WAP four-disulfide core domain 6A decreases expression ISO Malathion results in decreased expression of WFDC6 mRNA CTD PMID:37047231 NCBI chr 2:164,421,439...164,427,704
Ensembl chr 2:164,421,439...164,427,367
JBrowse link
G Wipf3 WAS/WASL interacting protein family, member 3 decreases expression ISO Malathion results in decreased expression of WIPF3 mRNA CTD PMID:37047231 NCBI chr 6:54,406,206...54,480,753
Ensembl chr 6:54,406,588...54,480,753
JBrowse link
G Wt1 WT1 transcription factor increases expression ISO Malathion results in increased expression of WT1 mRNA CTD PMID:32069766 NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961
JBrowse link
G Xkr4 X-linked Kx blood group related 4 decreases expression ISO Malathion results in decreased expression of XKR4 mRNA CTD PMID:37047231 NCBI chr 1:3,269,956...3,741,733
Ensembl chr 1:3,276,124...3,741,721
JBrowse link
G Zfp42 zinc finger protein 42 decreases expression ISO Malathion results in decreased expression of ZFP42 mRNA CTD PMID:37047231 NCBI chr 8:43,748,100...43,760,041
Ensembl chr 8:43,748,100...43,760,017
JBrowse link
G Zfpm2 zinc finger protein, multitype 2 increases expression ISO Malathion results in increased expression of ZFPM2 mRNA CTD PMID:37047231 NCBI chr15:40,518,438...40,967,988
Ensembl chr15:40,518,431...40,967,988
JBrowse link
G Zscan5b zinc finger and SCAN domain containing 5B decreases expression ISO Malathion results in decreased expression of ZSCAN5B mRNA CTD PMID:37047231 NCBI chr 7:6,225,277...6,242,416
Ensembl chr 7:6,225,277...6,242,422
JBrowse link
maleic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 6430550D23Rik RIKEN cDNA 6430550D23 gene increases expression ISO maleic acid results in increased expression of C20ORF173 mRNA CTD PMID:28392987 NCBI chr 2:155,831,465...155,850,315
Ensembl chr 2:155,815,199...155,849,897
JBrowse link
G Abca7 ATP-binding cassette, sub-family A member 7 increases expression ISO maleic acid results in increased expression of ABCA7 mRNA CTD PMID:28392987 NCBI chr10:79,832,328...79,851,406
Ensembl chr10:79,832,328...79,851,406
JBrowse link
G Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 increases expression ISO maleic acid results in increased expression of AGAP1 mRNA CTD PMID:28392987 NCBI chr 1:89,382,533...89,823,004
Ensembl chr 1:89,382,528...89,825,339
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 decreases expression ISO maleic acid results in decreased expression of AKT2 mRNA CTD PMID:28392987 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
JBrowse link
G B4galnt4 beta-1,4-N-acetyl-galactosaminyl transferase 4 decreases expression ISO maleic acid results in decreased expression of B4GALNT4 mRNA CTD PMID:28392987 NCBI chr 7:140,640,891...140,652,313
Ensembl chr 7:140,641,017...140,652,313
JBrowse link
G Ccbe1 collagen and calcium binding EGF domains 1 increases expression ISO maleic acid results in increased expression of CCBE1 mRNA CTD PMID:28392987 NCBI chr18:66,189,926...66,424,909
Ensembl chr18:66,178,373...66,435,812
JBrowse link
G Cldn2 claudin 2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2] CTD PMID:25119790 NCBI chr  X:138,701,552...138,712,135
Ensembl chr  X:138,701,577...138,712,135
JBrowse link
G Cldn25 claudin 25 increases expression ISO maleic acid results in increased expression of CLDN25 mRNA CTD PMID:28392987 NCBI chr 9:48,958,857...48,959,642
Ensembl chr 9:48,958,902...48,959,594
JBrowse link
G Cracr2b calcium release activated channel regulator 2B increases expression ISO maleic acid results in increased expression of CRACR2B mRNA CTD PMID:28392987 NCBI chr 7:141,041,007...141,046,526
Ensembl chr 7:141,041,007...141,046,526
JBrowse link
G Exoc3l2 exocyst complex component 3-like 2 increases expression ISO maleic acid results in increased expression of EXOC3L2 mRNA CTD PMID:28392987 NCBI chr 7:19,197,212...19,230,687
Ensembl chr 7:19,197,256...19,230,687
JBrowse link
G Fbxo40 F-box protein 40 increases expression ISO maleic acid results in increased expression of FBXO40 mRNA CTD PMID:28392987 NCBI chr16:36,783,823...36,811,321
Ensembl chr16:36,783,822...36,810,829
JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I increases expression ISO maleic acid results in increased expression of FCGR1A mRNA CTD PMID:28392987 NCBI chr 3:96,190,225...96,201,285
Ensembl chr 3:96,190,225...96,201,285
JBrowse link
G Fmo1 flavin containing monooxygenase 1 increases expression ISO maleic acid results in increased expression of FMO1 mRNA CTD PMID:28392987 NCBI chr 1:162,657,130...162,694,170
Ensembl chr 1:162,657,130...162,694,179
JBrowse link
G Gab3 growth factor receptor bound protein 2-associated protein 3 increases expression ISO maleic acid results in increased expression of GAB3 mRNA CTD PMID:28392987 NCBI chr  X:74,032,151...74,128,511
Ensembl chr  X:74,010,449...74,129,064
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 increases expression ISO maleic acid results in increased expression of GGT5 mRNA CTD PMID:28392987 NCBI chr10:75,425,161...75,453,034
Ensembl chr10:75,425,174...75,453,034
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor increases expression ISO maleic acid results in increased expression of GNRHR mRNA CTD PMID:28392987 NCBI chr 5:86,328,613...86,345,760
Ensembl chr 5:86,328,613...86,345,760
JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) increases expression ISO maleic acid results in increased expression of GRIA1 mRNA CTD PMID:28392987 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070
JBrowse link
G H2bc8 H2B clustered histone 8 decreases expression ISO maleic acid results in decreased expression of H2BC8 mRNA CTD PMID:28392987 NCBI chr13:23,755,574...23,756,037
Ensembl chr13:23,755,570...23,756,187
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression
multiple interactions
ISO maleic acid results in increased expression of HAVCR1 protein
Curcumin inhibits the reaction [maleic acid results in increased expression of HAVCR1 protein]
CTD PMID:25119790 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO maleic acid affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO maleic acid results in increased expression of IGF1 mRNA CTD PMID:28392987 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Kcnc1 potassium voltage gated channel, Shaw-related subfamily, member 1 decreases expression ISO maleic acid results in decreased expression of KCNC1 mRNA CTD PMID:28392987 NCBI chr 7:46,045,643...46,088,130
Ensembl chr 7:46,045,921...46,088,128
JBrowse link
G Lcn2 lipocalin 2 multiple interactions
increases secretion
ISO Curcumin inhibits the reaction [maleic acid results in increased secretion of LCN2 protein] CTD PMID:25119790 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
JBrowse link
G Nfat5 nuclear factor of activated T cells 5 increases expression ISO maleic acid results in increased expression of NFAT5 mRNA CTD PMID:28392987 NCBI chr 8:108,020,072...108,106,149
Ensembl chr 8:108,020,102...108,106,149
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
affects expression
ISO Curcumin inhibits the reaction [maleic acid affects the expression of NFE2L2 protein] CTD PMID:25119790 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Or11g2 olfactory receptor family 11 subfamily G member 2 increases expression ISO maleic acid results in increased expression of OR11G2 mRNA CTD PMID:28392987 NCBI chr14:50,855,681...50,856,652
Ensembl chr14:50,852,336...50,857,296
JBrowse link
G Or6c65 olfactory receptor family 6 subfamily C member 65 increases expression ISO maleic acid results in increased expression of OR6C65 mRNA CTD PMID:28392987 NCBI chr10:129,603,367...129,604,305
Ensembl chr10:129,601,351...129,607,582
JBrowse link
G Pcdhac1 protocadherin alpha subfamily C, 1 increases expression ISO maleic acid results in increased expression of PCDHAC1 mRNA CTD PMID:28392987 NCBI chr18:37,223,189...37,320,710
Ensembl chr18:37,223,066...37,320,710
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 decreases expression ISO maleic acid results in decreased expression of PDPK1 mRNA CTD PMID:28392987 NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898
JBrowse link
G Pkd1l1 polycystic kidney disease 1 like 1 increases expression ISO maleic acid results in increased expression of PKD1L1 mRNA CTD PMID:28392987 NCBI chr11:8,782,025...8,924,365
Ensembl chr11:8,776,708...8,923,266
JBrowse link
G Rsph6a radial spoke head 6 homolog A (Chlamydomonas) increases expression ISO maleic acid results in increased expression of RSPH6A mRNA CTD PMID:28392987 NCBI chr 7:18,788,603...18,808,384
Ensembl chr 7:18,788,615...18,808,372
JBrowse link
G S100a3 S100 calcium binding protein A3 increases expression ISO maleic acid results in increased expression of S100A3 mRNA CTD PMID:28392987 NCBI chr 3:90,467,571...90,510,922
Ensembl chr 3:90,491,966...90,510,009
JBrowse link
G Skap1 src family associated phosphoprotein 1 increases expression ISO maleic acid results in increased expression of SKAP1 mRNA CTD PMID:28392987 NCBI chr11:96,355,396...96,650,448
Ensembl chr11:96,355,419...96,649,956
JBrowse link
G Slc25a48 solute carrier family 25, member 48 increases expression ISO maleic acid results in increased expression of SLC25A48 mRNA CTD PMID:28392987 NCBI chr13:56,585,774...56,620,180
Ensembl chr13:56,586,168...56,622,052
JBrowse link
G Sox17 SRY (sex determining region Y)-box 17 increases expression ISO maleic acid results in increased expression of SOX17 mRNA CTD PMID:28392987 NCBI chr 1:4,561,154...4,567,624
Ensembl chr 1:4,561,154...4,567,577
JBrowse link
G Spata1 spermatogenesis associated 1 increases expression ISO maleic acid results in increased expression of SPATA1 mRNA CTD PMID:28392987 NCBI chr 3:146,162,955...146,205,548
Ensembl chr 3:146,162,951...146,205,508
JBrowse link
G Spem1 spermatid maturation 1 increases expression ISO maleic acid results in increased expression of SPEM1 mRNA CTD PMID:28392987 NCBI chr11:69,711,697...69,712,991
Ensembl chr11:69,711,702...69,713,006
JBrowse link
G Tcaf2 TRPM8 channel-associated factor 2 increases expression ISO maleic acid results in increased expression of TCAF2 mRNA CTD PMID:28392987 NCBI chr 6:42,599,950...42,622,134
Ensembl chr 6:42,599,950...42,622,188
JBrowse link
G Tnf tumor necrosis factor increases expression ISO maleic acid results in increased expression of TNF mRNA CTD PMID:28392987 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Zfp800 zinc finger protein 800 decreases expression ISO maleic acid results in decreased expression of ZNF800 mRNA CTD PMID:28392987 NCBI chr 6:28,210,543...28,398,010
Ensembl chr 6:28,239,926...28,398,004
JBrowse link
G Zgrf1 zinc finger, GRF-type containing 1 decreases expression ISO maleic acid results in decreased expression of ZGRF1 mRNA CTD PMID:28392987 NCBI chr 3:127,347,080...127,411,672
Ensembl chr 3:127,347,138...127,411,672
JBrowse link
maleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trp53 transformation related protein 53 multiple interactions ISO maleimide analog binds to and results in increased activity of TP53 protein mutant form CTD PMID:15998635 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
maleimides term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO Maleimides analog results in decreased activity of PTGS2 protein CTD PMID:8648609 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
malic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; [Glutamic Acid co-treated with malic acid] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein] CTD PMID:24732427 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial decreases abundance
multiple interactions
EXP IDH2 protein mutant form results in decreased abundance of malic acid
Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of malic acid]
CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
JBrowse link
G Mdh1 malate dehydrogenase 1, NAD (soluble) increases expression ISO malic acid deficiency results in increased expression of MDH1 mRNA CTD PMID:26811028 NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP [[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of malic acid CTD PMID:28223344 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO malic acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
methylmalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions
increases expression
ISO pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein] CTD PMID:28223158 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO Methylmalonic Acid results in increased expression of IL1B protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein]
CTD PMID:28223158 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein] CTD PMID:28223158 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Lepr leptin receptor affects abundance EXP LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
ISO pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein] CTD PMID:28223158 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein] CTD PMID:28223158 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
methylprednisolone succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis
ISO Dexamethasone promotes the reaction [CES2 protein results in increased hydrolysis of Methylprednisolone Hemisuccinate] CTD PMID:15794950 NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810
JBrowse link
monomethyl succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions EXP [alpha-ketoisocaproic acid co-treated with monomethyl succinate] inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO monomethyl succinate inhibits the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein] CTD PMID:21548882 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
N-ethylmaleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases activity ISO Ethylmaleimide results in decreased activity of ABCB1 protein CTD PMID:2900677 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 affects activity
multiple interactions
ISO Ethylmaleimide affects the activity of ABCC1 protein
Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
CTD PMID:9096673 PMID:9334814 PMID:16101123 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Alb albumin decreases transport ISO Ethylmaleimide results in decreased transport of ALB protein CTD PMID:15897811 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596
JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide multiple interactions
increases glutathionylation
ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532
JBrowse link
G Atp8b1 ATPase, class I, type 8B, member 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines] CTD PMID:11584374 NCBI chr18:64,662,050...64,794,342
Ensembl chr18:64,662,038...64,794,338
JBrowse link
G Cbr2 carbonyl reductase 2 increases acylation EXP Ethylmaleimide results in increased acylation of CBR2 protein CTD PMID:18597497 NCBI chr11:120,620,311...120,622,851
Ensembl chr11:120,620,315...120,622,940
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767
JBrowse link
G Chat choline acetyltransferase decreases activity EXP Ethylmaleimide results in decreased activity of CHAT protein CTD PMID:3437937 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions EXP Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] CTD PMID:10820281 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
JBrowse link
G Dusp23 dual specificity phosphatase 23 multiple interactions ISO Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr 1:172,458,336...172,460,504
Ensembl chr 1:172,458,331...172,460,529
JBrowse link
G F3 coagulation factor III increases expression ISO Ethylmaleimide results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases activity ISO Ethylmaleimide results in decreased activity of GAD1 protein CTD PMID:15836621 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
JBrowse link
G Gad2 glutamic acid decarboxylase 2 decreases activity ISO Ethylmaleimide results in decreased activity of GAD2 protein CTD PMID:15836621 NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886
JBrowse link
G Hoxb13 homeobox B13 increases response to substance ISO HOXB13 protein results in increased susceptibility to Ethylmaleimide CTD PMID:24213000 NCBI chr11:96,085,142...96,087,436
Ensembl chr11:96,085,142...96,088,273
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein] CTD PMID:22796344 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Ltbr lymphotoxin B receptor multiple interactions ISO Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr 6:125,283,534...125,291,026
Ensembl chr 6:125,283,534...125,290,848
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mt3 metallothionein 3 increases alkylation ISO Ethylmaleimide results in increased alkylation of MT3 protein CTD PMID:12383939 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774
JBrowse link
G Osm oncostatin M multiple interactions ISO Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr11:4,186,831...4,191,027
Ensembl chr11:4,186,420...4,191,026
JBrowse link
G Pah phenylalanine hydroxylase multiple interactions EXP Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998
JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein] CTD PMID:26060329 NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625
JBrowse link
G Senp6 SUMO/sentrin specific peptidase 6 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr 9:79,973,862...80,052,064
Ensembl chr 9:79,974,185...80,052,235
JBrowse link
G Slc12a5 solute carrier family 12, member 5 increases activity
multiple interactions
ISO Ethylmaleimide results in increased activity of SLC12A5 protein
Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD PMID:20086212 NCBI chr 2:164,802,766...164,841,651
Ensembl chr 2:164,802,722...164,841,651
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions EXP
ISO
Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839
JBrowse link
G Sumo2 small ubiquitin-like modifier 2 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr11:115,413,935...115,427,056
Ensembl chr11:115,413,928...115,427,102
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trf transferrin decreases uptake EXP Ethylmaleimide results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
JBrowse link
G Vdac1 voltage-dependent anion channel 1 affects binding ISO Ethylmaleimide binds to VDAC1 protein CTD PMID:20192921 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224
JBrowse link
N-Ethylmaleimide-S-glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc6 ATP-binding cassette, sub-family C member 6 multiple interactions
affects transport
ISO Benzbromarone inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]; Indomethacin inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]; Probenecid inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione] CTD PMID:11880368 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726
JBrowse link
N-methyl-D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
ISO kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of AKT1 protein] CTD PMID:26065936 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP1A1 protein] CTD PMID:34389372 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000
JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP1A2 protein] CTD PMID:34389372 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
JBrowse link
G Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP2B1 protein] CTD PMID:34389372 NCBI chr10:98,750,243...98,862,005
Ensembl chr10:98,750,268...98,862,005
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
ISO N-Methylaspartate results in increased expression of BAX protein
kukoamine B inhibits the reaction [N-Methylaspartate results in increased expression of BAX protein]
CTD PMID:26065936 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO kukoamine B inhibits the reaction [N-Methylaspartate results in decreased expression of BCL2 protein] CTD PMID:26065936 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNA1A protein] CTD PMID:34389372 NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875
JBrowse link
G Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNA1B protein] CTD PMID:34389372 NCBI chr 2:24,493,872...24,653,210
Ensembl chr 2:24,493,899...24,653,164
JBrowse link
G Cacnb1 calcium channel, voltage-dependent, beta 1 subunit multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNB1 protein] CTD PMID:34389372 NCBI chr11:97,892,339...97,913,860
Ensembl chr11:97,892,334...97,913,860
JBrowse link
G Cacnb4 calcium channel, voltage-dependent, beta 4 subunit multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNB4 protein] CTD PMID:34389372 NCBI chr 2:52,318,332...52,566,816
Ensembl chr 2:52,318,337...52,566,843
JBrowse link
G Capn2 calpain 2 increases activity ISO NMDA increases activity of Capn2 in rat hippocampal neuron cultures RGD PMID:19141074 RGD:13792555 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173
JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions
increases phosphorylation
ISO CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]; CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]
N-Methylaspartate results in increased phosphorylation of CAV1 protein
CTD PMID:35257817 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451
JBrowse link
G Cdk5 cyclin dependent kinase 5 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CDK5 protein] CTD PMID:34389372 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions
ISO N-Methylaspartate results in decreased phosphorylation of CREB1 protein
kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of CREB1 protein]
CTD PMID:26065936 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Ddo D-aspartate oxidase affects abundance EXP DDO protein affects the abundance of N-Methylaspartate CTD PMID:16516413 NCBI chr10:40,505,933...40,557,847
Ensembl chr10:40,506,007...40,557,843
JBrowse link
G Dlgap1 DLG associated protein 1 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of DLGAP1 protein] CTD PMID:34389372 NCBI chr17:70,276,068...71,128,408
Ensembl chr17:70,276,068...71,128,408
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 increases phosphorylation
multiple interactions
ISO N-Methylaspartate results in increased phosphorylation of ELAVL1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]
CTD PMID:31945382 NCBI chr 8:4,334,781...4,375,104
Ensembl chr 8:4,335,382...4,375,413
JBrowse link
G Fyn Fyn proto-oncogene multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of FYN protein] CTD PMID:34389372 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377
JBrowse link
G Gphn gephyrin multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of GPHN protein] CTD PMID:34389372 NCBI chr12:78,264,099...78,731,546
Ensembl chr12:78,273,153...78,731,546
JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) increases expression
multiple interactions
ISO N-Methylaspartate results in increased expression of GRIN2B protein
kukoamine B inhibits the reaction [N-Methylaspartate results in increased expression of GRIN2B protein]
CTD PMID:26065936 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of GSK3B protein] CTD PMID:34389372 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Hcn2 hyperpolarization-activated, cyclic nucleotide-gated K+ 2 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of HCN2 protein] CTD PMID:34389372 NCBI chr10:79,552,468...79,571,942
Ensembl chr10:79,552,468...79,571,942
JBrowse link
G Lmna lamin A multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of LMNA protein] CTD PMID:34389372 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
increases expression
ISO thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form]
N-Methylaspartate results in increased phosphorylation of MAPK1 protein
N-Methylaspartate results in decreased phosphorylation of MAPK1 protein
CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]; kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]
CTD PMID:22639866 PMID:26065936 PMID:35257817 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation
increases expression
ISO thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK3 protein modified form]
N-Methylaspartate results in increased phosphorylation of MAPK3 protein
CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]; kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]
CTD PMID:22639866 PMID:26065936 PMID:35257817 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of MAPT protein] CTD PMID:34389372 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects localization
multiple interactions
ISO N-Methylaspartate affects the localization of NCF1 protein
acetovanillone inhibits the reaction [N-Methylaspartate affects the localization of NCF1 protein]
CTD PMID:26065936 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions
decreases expression
ISO 3-(2-((phenylamino)carbonyl)ethenyl)-4,6-dichloroindole-2-carboxylic acid inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Memantine inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA] CTD PMID:31969611 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of NOS1 protein] CTD PMID:34389372 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases ADP-ribosylation ISO N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein CTD PMID:16903875 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of PRKCG protein] CTD PMID:34389372 NCBI chr 7:3,352,038...3,379,615
Ensembl chr 7:3,337,704...3,379,615
JBrowse link
G Rab3a RAB3A, member RAS oncogene family multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of RAB3A protein] CTD PMID:34389372 NCBI chr 8:71,207,258...71,211,276
Ensembl chr 8:71,207,328...71,211,323
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of RIMS1 protein] CTD PMID:34389372 NCBI chr 1:22,356,196...22,845,239
Ensembl chr 1:22,356,475...22,845,203
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 decreases expression ISO N-Methylaspartate results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr 7:143,531,819...143,979,780
Ensembl chr 7:143,555,665...143,978,231
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of SHANK3 protein] CTD PMID:34389372 NCBI chr15:89,376,929...89,444,464
Ensembl chr15:89,383,826...89,444,464
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein CTD PMID:31945382 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Stxbp1 syntaxin binding protein 1 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of STXBP1 protein] CTD PMID:34389372 NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257
JBrowse link
G Syn1 synapsin I multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of SYN1 protein] CTD PMID:34389372 NCBI chr  X:20,726,750...20,787,157
Ensembl chr  X:20,726,750...20,787,243
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression
ISO CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; U 0126 inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]
N-Methylaspartate results in decreased expression of TJP1 mRNA; N-Methylaspartate results in decreased expression of TJP1 protein
CTD PMID:35257817 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
JBrowse link
G Tuba1b tubulin, alpha 1B multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of TUBA1B protein] CTD PMID:34389372 NCBI chr15:98,829,310...98,832,271
Ensembl chr15:98,829,306...98,832,446
JBrowse link
G Vdac2 voltage-dependent anion channel 2 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of VDAC2 protein] CTD PMID:34389372 NCBI chr14:21,881,629...21,895,947
Ensembl chr14:21,875,306...21,895,947
JBrowse link
oxaloacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Got1 glutamic-oxaloacetic transaminase 1, soluble increases expression ISO Oxaloacetic Acid results in increased expression of GOT1 mRNA CTD PMID:26811028 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044
JBrowse link
G Mdh1 malate dehydrogenase 1, NAD (soluble) increases expression ISO Oxaloacetic Acid results in increased expression of MDH1 protein CTD PMID:26811028 NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367
JBrowse link
G mt-Co2 cytochrome c oxidase II, mitochondrial increases expression ISO Oxaloacetic Acid results in increased expression of COX2 mRNA; Oxaloacetic Acid results in increased expression of COX2 protein CTD PMID:26811028 NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1A mRNA; Oxaloacetic Acid results in increased expression of PPARGC1A protein CTD PMID:23056435 PMID:26811028 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1B protein CTD PMID:26811028 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502
JBrowse link
G Pprc1 peroxisome proliferative activated receptor, gamma, coactivator-related 1 increases expression ISO Oxaloacetic Acid results in increased expression of PPRC1 mRNA; Oxaloacetic Acid results in increased expression of PPRC1 protein CTD PMID:26811028 NCBI chr19:46,044,955...46,061,348
Ensembl chr19:46,033,325...46,061,354
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Oxaloacetic Acid results in increased expression of TFAM mRNA CTD PMID:26811028 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110
JBrowse link
Ro 31-8220 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 multiple interactions
decreases expression
ISO Ro 31-8220 inhibits the reaction [5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased expression of ABCA1 mRNA]
Ro 31-8220 results in decreased expression of ABCA1 mRNA
CTD PMID:15037193 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Ro 31-8220 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein] CTD PMID:36925031 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BCL2 protein] CTD PMID:36925031 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein] CTD PMID:22001173 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Ro 31-8220 results in increased activity of CASP3 protein
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]; Ro 31-8220 inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]
CTD PMID:17561261 PMID:18054255 PMID:22001173 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 increases activity ISO Ro 31-8220 results in increased activity of CASP8 protein CTD PMID:18054255 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein] CTD PMID:22001173 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cd38 CD38 antigen multiple interactions ISO Ro 31-8220 inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA] CTD PMID:21393419 NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]; Ro 31-8220 inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]
Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]
CTD PMID:15522277 PMID:16280361 PMID:22138297 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Ro 31-8220 inhibits the reaction [Neurotensin results in increased expression of CXCL8 mRNA] CTD PMID:17000667 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Dpp3 dipeptidylpeptidase 3 multiple interactions ISO Ro 31-8220 inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr19:4,957,257...4,978,315
Ensembl chr19:4,957,257...4,978,315
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein] CTD PMID:12169099 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein] CTD PMID:12947092 PMID:16877402 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide multiple interactions EXP Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA]; Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA] CTD PMID:16818790 NCBI chr 1:173,048,836...173,054,799
Ensembl chr 1:173,048,851...173,054,781
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
decreases expression
EXP Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
Ro 31-8220 results in decreased expression of FOS mRNA
CTD PMID:11353138 PMID:11568973 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein] CTD PMID:18058799 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of GJA1 protein] CTD PMID:36925031 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO Ro 31-8220 promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:66,005,826...66,019,670
Ensembl chr18:66,005,891...66,019,667
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO Ro 31-8220 results in decreased activity of GSK3B protein CTD PMID:10998351 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] CTD PMID:18048804 PMID:18357586 PMID:26275128 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hrh1 histamine receptor H1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA] CTD PMID:18360087 NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257
JBrowse link
G Il11 interleukin 11 multiple interactions ISO Ro 31-8220 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL11 mRNA] CTD PMID:22138297 NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ro 31-8220 inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:10712238 PMID:11854442 PMID:18054255 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA] CTD PMID:16818790 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins1 insulin I multiple interactions EXP
ISO
Ro 31-8220 inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]
Ro 31-8220 inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]
CTD PMID:14511371 PMID:19070612 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Jun jun proto-oncogene multiple interactions
decreases expression
EXP
ISO
Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]
Ro 31-8220 results in decreased expression of JUN mRNA
Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]
CTD PMID:11353138 PMID:11568973 PMID:12169099 PMID:19002563 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]
Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:10712238 PMID:12083801 PMID:16877402 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]
Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:10712238 PMID:12083801 PMID:16877402 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Ro 31-8220 inhibits the reaction [Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK8 protein] CTD PMID:11756236 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Ro 31-8220 inhibits the reaction [Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK9 protein] CTD PMID:11756236 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein] CTD PMID:12605413 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression
EXP Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Ro 31-8220 inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]
Ro 31-8220 results in decreased expression of MT1 mRNA
CTD PMID:11551972 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Ro 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of NOS2 protein] CTD PMID:32416088 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein]; Ro 31-8220 inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nts neurotensin increases activity
multiple interactions
ISO Ro 31-8220 results in increased activity of NTS protein
Ro 31-8220 affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; Tetradecanoylphorbol Acetate inhibits the reaction [Ro 31-8220 results in increased activity of NTS protein]
CTD PMID:18313772 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory inhibitor subunit 14A multiple interactions ISO Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein] CTD PMID:18986333 NCBI chr 7:28,988,732...28,992,817
Ensembl chr 7:28,988,733...28,993,226
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP
ISO
Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCA protein]
Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein]
CTD PMID:32416088 PMID:36925031 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCE protein] CTD PMID:32416088 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions EXP Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCG protein] CTD PMID:32416088 NCBI chr 7:3,352,038...3,379,615
Ensembl chr 7:3,337,704...3,379,615
JBrowse link
G Prkci protein kinase C, iota decreases activity EXP Ro 31-8220 results in decreased activity of PRKCI protein CTD PMID:14511371 NCBI chr 3:31,049,893...31,106,889
Ensembl chr 3:31,049,896...31,107,108
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Ro 31-8220 inhibits the reaction [NCX 4040 results in increased expression of PTGS2 protein]
Ro 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]
CTD PMID:11854442 PMID:19576865 PMID:32416088 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form] CTD PMID:18986333 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Rnf187 ring finger protein 187 multiple interactions
decreases stability
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ro 31-8220 results in decreased stability of RNF187 protein] CTD PMID:25851810 NCBI chr11:58,823,114...58,829,732
Ensembl chr11:58,823,114...58,829,742
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 decreases activity ISO Ro 31-8220 results in decreased activity of RPS6KA5 protein CTD PMID:15522277 NCBI chr12:100,514,692...100,691,693
Ensembl chr12:100,514,698...100,693,242
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA] CTD PMID:15037193 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
JBrowse link
G Sftpb surfactant associated protein B multiple interactions ISO Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]; Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPB protein] CTD PMID:11704537 NCBI chr 6:72,281,594...72,291,354
Ensembl chr 6:72,281,594...72,291,354
JBrowse link
G Sftpc surfactant associated protein C multiple interactions ISO Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]; Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPC protein] CTD PMID:11704537 NCBI chr14:70,758,381...70,761,521
Ensembl chr14:70,758,389...70,761,521
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA] CTD PMID:16818790 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions ISO Ro 31-8220 inhibits the reaction [decitabine results in increased expression of TNFSF10 protein] CTD PMID:17283156 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Ro 31-8220 results in decreased expression of VEGFA mRNA CTD PMID:12590138 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
SAICAR term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pkm pyruvate kinase, muscle multiple interactions ISO Glucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein] CTD PMID:23086999 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658
JBrowse link
sarpogrelate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-Coenzyme A acetyltransferase 1 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein] CTD PMID:16157345 NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO sarpogrelate results in increased expression of ADIPOQ protein CTD PMID:18235151 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G Adra1a adrenergic receptor, alpha 1a multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein] CTD PMID:11937776 NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617
JBrowse link
G Adra1b adrenergic receptor, alpha 1b multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein] CTD PMID:11937776 NCBI chr11:43,665,432...43,792,076
Ensembl chr11:43,665,433...43,792,037
JBrowse link
G Adra1d adrenergic receptor, alpha 1d multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein] CTD PMID:11937776 NCBI chr 2:131,387,277...131,404,417
Ensembl chr 2:131,387,770...131,404,203
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] CTD PMID:22975078 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 affects expression ISO sarpogrelate affects the expression of ATP2A2 mRNA; sarpogrelate affects the expression of ATP2A2 protein CTD PMID:18088389 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO
EXP
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of BAX protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]
CTD PMID:34560070 PMID:35202708 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; sarpogrelate inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; sarpogrelate inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]
CTD PMID:34560070 PMID:35202708 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
CTD PMID:34560070 PMID:35202708 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]
CTD PMID:34560070 PMID:35202708 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP
ISO
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]
sarpogrelate results in decreased expression of CCL2 protein
CTD PMID:18235151 PMID:26824242 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity
multiple interactions
ISO sarpogrelate metabolite results in decreased activity of CYP2D6 protein; sarpogrelate results in decreased activity of CYP2D6 protein
sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]
CTD PMID:24167220 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Ddc dopa decarboxylase multiple interactions EXP
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of DDC protein] CTD PMID:34560070 PMID:35202708 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP
ISO
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]
CTD PMID:35202708 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823
JBrowse link
G Fabp1 fatty acid binding protein 1, liver multiple interactions EXP sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of FABP1 protein] CTD PMID:24107419 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO
EXP
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]
CTD PMID:35202708 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]] CTD PMID:35202708 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Htr1b 5-hydroxytryptamine (serotonin) receptor 1B multiple interactions ISO sarpogrelate inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]; sarpogrelate metabolite inhibits the reaction [Iodocyanopindolol binds to HTR1B protein] CTD PMID:8937629 NCBI chr 9:81,510,344...81,515,885
Ensembl chr 9:81,510,344...81,515,881
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A multiple interactions
affects binding
ISO sarpogrelate binds to and results in decreased activity of HTR2A protein; sarpogrelate binds to and results in decreased activity of HTR2A protein mutant form; sarpogrelate metabolite binds to and results in decreased activity of HTR2A protein
sarpogrelate binds to HTR2A protein; sarpogrelate metabolite binds to HTR2A protein
CTD PMID:8937629 PMID:16974069 PMID:17031071 PMID:19672037 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934
JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C affects binding ISO sarpogrelate binds to HTR2C protein CTD PMID:16880620 NCBI chr  X:145,745,509...145,980,273
Ensembl chr  X:145,745,509...145,980,273
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO sarpogrelate inhibits the reaction [Glucose results in increased expression of ICAM1 protein] CTD PMID:23111892 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Il18 interleukin 18 decreases expression ISO sarpogrelate results in decreased expression of IL18 protein CTD PMID:15080020 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD PMID:34560070 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:11076827 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] CTD PMID:22975078 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137
JBrowse link
G Kdr kinase insert domain protein receptor multiple interactions EXP sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
JBrowse link
G Maoa monoamine oxidase A multiple interactions EXP
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]] CTD PMID:34560070 PMID:35202708 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Mfn1 mitofusin 1 multiple interactions EXP
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]
CTD PMID:35202708 NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of MMP13 mRNA] CTD PMID:25931318 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G mt-Atp6 ATP synthase 6, mitochondrial multiple interactions ISO
EXP
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]
CTD PMID:35202708 NCBI chr MT:7,927...8,607
Ensembl chr MT:7,927...8,607
JBrowse link
G mt-Cytb cytochrome b, mitochondrial multiple interactions ISO
EXP
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]
CTD PMID:35202708 NCBI chr MT:14,145...15,288
Ensembl chr MT:14,145...15,288
JBrowse link
G mt-Nd1 NADH dehydrogenase 1, mitochondrial multiple interactions ISO
EXP
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]
CTD PMID:35202708 NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO sarpogrelate inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]; sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein] CTD PMID:27133527 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO sarpogrelate promotes the reaction [Oxygen deficiency results in increased expression of NOS3 protein] CTD PMID:25931318 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 multiple interactions EXP sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] CTD PMID:27097221 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454
JBrowse link
G Pln phospholamban affects expression ISO sarpogrelate affects the expression of PLN mRNA; sarpogrelate affects the expression of PLN protein CTD PMID:18088389 NCBI chr10:53,213,782...53,222,095
Ensembl chr10:53,213,763...53,222,083
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein] CTD PMID:21262218 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] CTD PMID:34560070 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 decreases expression
multiple interactions
EXP sarpogrelate results in decreased expression of SERPINE2 mRNA
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
CTD PMID:24107419 PMID:27097221 NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 affects expression ISO sarpogrelate affects the expression of SLC2A1 protein CTD PMID:21183729 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 affects expression ISO sarpogrelate affects the expression of SLC2A4 protein CTD PMID:21183729 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA] CTD PMID:24650663 NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein] CTD PMID:34560070 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:24107419 PMID:27097221 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of TNF protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:34560070 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions ISO
EXP
sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TPH1 protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TPH1 protein]
CTD PMID:34560070 PMID:35202708 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of sarpogrelate metabolite CTD PMID:23704698 NCBI chr 1:88,093,734...88,147,724
Ensembl chr 1:88,093,734...88,146,719
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of sarpogrelate metabolite CTD PMID:23704698 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein] CTD PMID:22785018 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
SB 415286 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Copper affects the localization of APP protein] CTD PMID:24610780 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein] CTD PMID:33548343 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP8 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased activity of CASP8 protein] CTD PMID:15475000 PMID:15942663 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of CCND1 mRNA
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione co-treated with WNT3A protein] results in increased expression of CCND1 mRNA; bisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of CCND1 mRNA]
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]
CTD PMID:15753396 PMID:25381574 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased phosphorylation of CREB1 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]
CTD PMID:23292070 PMID:29723552 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein CTD PMID:19159680 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Dbn1 drebrin 1 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]] CTD PMID:33548343 NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]] CTD PMID:33548343 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased phosphorylation of DPYSL2 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]] CTD PMID:33548343 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,106,137
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein] CTD PMID:15475000 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases activity
ISO
EXP
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein]
CTD PMID:15753396 PMID:19159680 PMID:31563592 PMID:33548343 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gys1 glycogen synthase 1, muscle multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in increased phosphorylation of GYS1 protein] CTD PMID:23292070 NCBI chr 7:45,084,263...45,106,041
Ensembl chr 7:45,084,268...45,106,043
JBrowse link
G Il6 interleukin 6 multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA] CTD PMID:24560772 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 increases expression
multiple interactions
ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA
bisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]; WNT3A protein promotes the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]
CTD PMID:25381574 NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] CTD PMID:22155090 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:23292070 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631
JBrowse link
G Syp synaptophysin multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]] CTD PMID:33548343 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cisplatin results in increased expression of TNF mRNA] CTD PMID:24560772 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Wnt3a wingless-type MMTV integration site family, member 3A multiple interactions ISO [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione co-treated with WNT3A protein] results in increased expression of CCND1 mRNA; WNT3A protein promotes the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA] CTD PMID:25381574 NCBI chr11:59,138,859...59,181,579
Ensembl chr11:59,138,859...59,181,578
JBrowse link
sotrastaurin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin multiple interactions ISO sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]; sotrastaurin inhibits the reaction [Selective Estrogen Receptor Modulators results in decreased expression of AVP mRNA] CTD PMID:26200092 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK1 protein]; sotrastaurin inhibits the reaction [Selective Estrogen Receptor Modulators results in increased phosphorylation of MAPK1 protein] CTD PMID:26200092 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK3 protein]; sotrastaurin inhibits the reaction [Selective Estrogen Receptor Modulators results in increased phosphorylation of MAPK3 protein] CTD PMID:26200092 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Prkcb protein kinase C, beta decreases activity
multiple interactions
ISO sotrastaurin results in decreased activity of PRKCB protein
sotrastaurin inhibits the reaction [docetaxel results in increased phosphorylation of PRKCB protein]
CTD PMID:25634538 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625
JBrowse link
succinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX protein CTD PMID:31401087 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 protein CTD PMID:31401087 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid] CTD PMID:24709313 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
JBrowse link
G Dek DEK proto-oncogene multiple interactions ISO DEK protein affects the chemical synthesis of and affects the secretion of Succinic Acid CTD PMID:28558019 NCBI chr13:47,238,243...47,261,134
Ensembl chr13:47,238,251...47,259,677
JBrowse link
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 increases abundance EXP ERCC6 gene mutant form results in increased abundance of Succinic Acid CTD PMID:25440059 NCBI chr14:32,235,248...32,302,947
Ensembl chr14:32,235,478...32,302,947
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO Succinic Acid inhibits the reaction [Rotenone affects the expression of HIF1A protein] CTD PMID:16034640 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Lepr leptin receptor affects abundance EXP LEPR affects the abundance of Succinic Acid CTD PMID:20567778 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC protein CTD PMID:31401087 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of NFKB1 mRNA CTD PMID:31401087 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP [Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA CTD PMID:20505214 NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 protein CTD PMID:31401087 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of RELA mRNA CTD PMID:31401087 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 affects binding EXP
ISO
Succinic Acid binds to SLC13A3 protein CTD PMID:12397032 NCBI chr 2:165,247,215...165,315,117
Ensembl chr 2:165,246,948...165,315,150
JBrowse link
G Slc22a19 solute carrier family 22 (organic anion transporter), member 19 multiple interactions ISO Succinic Acid affects the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Succinic Acid inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate] CTD PMID:16079298 PMID:18441515 NCBI chr19:7,650,440...7,688,675
Ensembl chr19:7,650,426...7,688,675
JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 increases activity
multiple interactions
ISO Succinic Acid results in increased activity of SLC22A6 protein
[Succinic Acid results in increased activity of SLC22A6 protein] which results in increased uptake of p-Aminohippuric Acid
CTD PMID:36958672 NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 increases activity
multiple interactions
ISO Succinic Acid results in increased activity of SLC22A8 protein
[Succinic Acid results in increased activity of SLC22A8 protein] which results in increased uptake of p-Aminohippuric Acid
CTD PMID:36958672 NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance EXP SLCO1A4 protein affects the abundance of Succinic Acid CTD PMID:21561886 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of STAT3 mRNA CTD PMID:31401087 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
succinylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase increases response to substance
increases metabolic processing
increases hydrolysis
affects hydrolysis
multiple interactions
decreases abundance
decreases hydrolysis
affects response to substance
ISO BCHE gene mutant form results in increased susceptibility to Succinylcholine; BCHE gene polymorphism results in increased susceptibility to Succinylcholine; BCHE protein mutant form results in increased susceptibility to Succinylcholine
BCHE protein results in increased metabolism of Succinylcholine
BCHE protein results in increased hydrolysis of Succinylcholine
BCHE protein mutant form affects the hydrolysis of Succinylcholine
[Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]
BCHE protein results in decreased abundance of Succinylcholine
BCHE protein mutant form results in decreased hydrolysis of Succinylcholine
BCHE affects the susceptibility to Succinylcholine; BCHE gene mutant form affects the susceptibility to Succinylcholine; BCHE gene polymorphism affects the susceptibility to Succinylcholine; BCHE protein affects the susceptibility to Succinylcholine
CTD PMID:726855 PMID:900467 PMID:987736 PMID:1058931 PMID:1147298 More... NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 multiple interactions ISO Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939
JBrowse link
G Mb myoglobin increases secretion ISO Succinylcholine results in increased secretion of MB protein CTD PMID:8217179 NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870
JBrowse link
suxibuzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pklr pyruvate kinase liver and red blood cell decreases activity ISO suxibuzone results in decreased activity of PKLR protein CTD PMID:3107799 NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091
JBrowse link
tetramethrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
decreases expression
ISO tetramethrin results in decreased activity of [Dihydrotestosterone results in increased activity of AR protein]
tetramethrin results in decreased expression of AR mRNA
CTD PMID:12711008 PMID:16621434 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Brca1 breast cancer 1, early onset affects binding ISO tetramethrin binds to BRCA1 protein CTD PMID:32278787 NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases metabolic processing
ISO CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein]
CES2 protein results in increased metabolism of tetramethrin
CTD PMID:19249324 NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810
JBrowse link
G Esr1 estrogen receptor 1 (alpha) decreases expression ISO tetramethrin results in decreased expression of ESR1 protein CTD PMID:16326440 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) increases expression ISO tetramethrin results in increased expression of ESR2 protein CTD PMID:16326440 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Folh1 folate hydrolase 1 decreases expression ISO tetramethrin results in decreased expression of FOLH1 mRNA CTD PMID:12711008 NCBI chr 7:86,365,733...86,425,171
Ensembl chr 7:86,368,185...86,425,151
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP tetramethrin inhibits the reaction [IGF1 protein results in increased import of Calcium] CTD PMID:1550224 PMID:2460452 PMID:2539779 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions EXP tetramethrin inhibits the reaction [IGF2 protein results in increased import of Calcium] CTD PMID:2442157 PMID:2539779 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO tetramethrin results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO tetramethrin results in decreased expression of NKX3-1 mRNA CTD PMID:12711008 NCBI chr14:69,428,141...69,432,107
Ensembl chr14:69,428,087...69,432,111
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein] CTD PMID:19249324 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin] results in increased activity of NR3C1 protein; [tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein CTD PMID:25448277 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
JBrowse link
G S100g S100 calcium binding protein G decreases expression
multiple interactions
ISO tetramethrin results in decreased expression of S100G mRNA
tetramethrin inhibits the reaction [Estradiol results in increased expression of S100G mRNA]
CTD PMID:16326440 NCBI chr  X:161,744,988...161,747,595
Ensembl chr  X:161,744,988...161,747,595
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO tetramethrin binds to SHBG protein CTD PMID:32278787 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731
JBrowse link
thiomalic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G multiple interactions ISO [Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG protein CTD PMID:16407272 NCBI chr 2:30,061,525...30,064,057
Ensembl chr 2:30,061,505...30,064,081
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity ISO 2-thiomalic acid results in decreased activity of GPX1 protein CTD PMID:21892612 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 2-thiomalic acid promotes the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein] CTD PMID:10486238 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
U-73122 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenergic receptor, alpha 1a multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose] CTD PMID:15550506 NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617
JBrowse link
G Adra2a adrenergic receptor, alpha 2a multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] CTD PMID:10742289 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413
JBrowse link
G Agt angiotensinogen multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [AGT protein affects the localization of Calcium]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] CTD PMID:18250367 PMID:21613610 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:15177934 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] CTD PMID:19013290 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
JBrowse link
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr 1:154,266,552...154,760,374
Ensembl chr 1:154,266,477...154,760,247
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein] CTD PMID:19927300 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503
JBrowse link
G Cck cholecystokinin multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein] CTD PMID:25787141 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760
JBrowse link
G Ccl26 C-C motif chemokine ligand 26 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein] CTD PMID:37788752 NCBI chr 5:135,589,302...135,592,423
Ensembl chr 5:135,589,302...135,592,423
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein] CTD PMID:37788752 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726
JBrowse link
G Cd40 CD40 antigen multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] CTD PMID:18316702 NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of CREB1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of CREB1 protein]
CTD PMID:17680988 PMID:33421459 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased secretion of CXCL8 protein] CTD PMID:30623574 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [imidacloprid affects the expression of CYP19A1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [thiacloprid affects the expression of CYP19A1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA] CTD PMID:29701941 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of DLG4 protein] CTD PMID:33421459 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine] CTD PMID:14759557 PMID:15245872 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Edn3 endothelin 3 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine] CTD PMID:14759557 PMID:15245872 NCBI chr 2:174,602,412...174,625,835
Ensembl chr 2:174,602,412...174,625,835
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G F2 coagulation factor II multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [F2 protein results in increased localization of Calcium] CTD PMID:19814731 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA] CTD PMID:19225867 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gcg glucagon multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form] CTD PMID:25787141 NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Gnas GNAS complex locus multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[6alpha-ethyl-23(S)-methylcholic acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols] CTD PMID:23022524 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[6alpha-ethyl-23(S)-methylcholic acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols] CTD PMID:23022524 NCBI chr 1:74,316,269...74,318,868
Ensembl chr 1:74,317,709...74,318,783
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of HSPA5 protein] CTD PMID:33421459 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein affects the localization of PRKCA protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased phosphorylation of SRC protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B]]
CTD PMID:19281832 PMID:22214447 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein] CTD PMID:24631921 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins1 insulin I multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[4-(3-3,4-p-menthadien-(1,8)-yl)olivetol co-treated with Glucose] results in increased secretion of INS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[O-1602 compound co-treated with Glucose] results in increased secretion of INS1 protein] CTD PMID:31054273 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Ip6k1 inositol hexaphosphate kinase 1 decreases activity ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of IP6K1 protein CTD PMID:29042286 NCBI chr 9:107,879,847...107,925,981
Ensembl chr 9:107,879,700...107,925,981
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA] CTD PMID:19225867 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kng1 kininogen 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein results in increased susceptibility to Capsaicin] CTD PMID:16696851 PMID:17324588 NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828
JBrowse link
G Lep leptin multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Permethrin results in increased phosphorylation of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [desnitroimidacloprid results in increased phosphorylation of MAPK1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Estradiol results in increased activity of MAPK1 protein]
CTD PMID:12460746 PMID:15034929 PMID:15177934 PMID:15355987 PMID:16713447 More... NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Permethrin results in increased phosphorylation of MAPK3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [desnitroimidacloprid results in increased phosphorylation of MAPK3 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Estradiol results in increased activity of MAPK3 protein]
CTD PMID:12460746 PMID:15034929 PMID:15177934 PMID:15355987 PMID:16713447 More... NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein] CTD PMID:19927300 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein] CTD PMID:21245013 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
JBrowse link
G Nefm neurofilament, medium polypeptide multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]] CTD PMID:22214447 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nppa natriuretic peptide type A multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA] CTD PMID:15240149 PMID:16714034 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536
JBrowse link
G Nts neurotensin multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15177934 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347
JBrowse link
G Plcb1 phospholipase C, beta 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of PLCB1 mRNA]
CTD PMID:16714034 PMID:33421459 NCBI chr 2:134,628,084...135,317,178
Ensembl chr 2:134,627,987...135,317,178
JBrowse link
G Plcb3 phospholipase C, beta 3 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein] CTD PMID:16714034 NCBI chr19:6,931,081...6,951,738
Ensembl chr19:6,929,693...6,953,838
JBrowse link
G Plcd1 phospholipase C, delta 1 decreases activity
multiple interactions
EXP
ISO
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of PLCD1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]
CTD PMID:16618758 PMID:16714034 NCBI chr 9:118,900,595...118,922,570
Ensembl chr 9:118,900,595...118,922,570
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [iodixanol results in increased phosphorylation of PLCG1 protein]
CTD PMID:16714034 PMID:34774977 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP
ISO
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [Corticosterone results in increased activity of PRKCA protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein affects the localization of PRKCA protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of PRKCA mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of PRKCA protein]
CTD PMID:16581232 PMID:19281832 PMID:33421459 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer affects the localization of PRKCD protein] CTD PMID:29669290 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]] CTD PMID:22214447 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] CTD PMID:18250367 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Selp selectin, platelet multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [resveratrol inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]]; resveratrol promotes the reaction [1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]] CTD PMID:18291361 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein] CTD PMID:27160165 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
G Src Rous sarcoma oncogene multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased phosphorylation of SRC protein] CTD PMID:19281832 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [25-hydroxyprotopanaxadiol results in increased phosphorylation of STK11 protein] CTD PMID:33676887 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516
JBrowse link
G Syp synaptophysin multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of SYP protein] CTD PMID:33421459 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495
JBrowse link
G Tac1 tachykinin 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [GR 73632 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]] CTD PMID:16696851 PMID:18809416 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]] CTD PMID:22214447 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein] CTD PMID:15046718 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases activity
multiple interactions
EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of TRPC6 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased activity of TRPC6 protein]
CTD PMID:11179201 PMID:17603544 NCBI chr 9:8,543,868...8,680,753
Ensembl chr 9:8,544,143...8,680,742
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Menthol results in increased activity of TRPM8] CTD PMID:15046718 NCBI chr 1:88,234,457...88,318,909
Ensembl chr 1:88,205,383...88,317,015
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [GR 73632 results in increased phosphorylation of TRPV1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein] CTD PMID:18172555 PMID:18809416 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19281832 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Vim vimentin multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22188
    chemical entity 22187
      group 22082
        inorganic group 21027
          oxo group 20159
            organic oxo compound 20159
              carbonyl compound 20159
                dicarboxylic acids and O-substituted derivatives 10883
                  dicarboxylic acid 10876
                    C4-dicarboxylic acid 1322
                      2-chlorosuccinic acid 0
                      2-hydroxy-3-oxosuccinic acid + 0
                      3-hydroxyaspartic acid + 0
                      3-methylthioaspartic acid + 0
                      3-thio-L-aspartic acid + 0
                      N-carbamoylaspartic acid + 0
                      N-formimidoyl-L-aspartic acid 0
                      aspartic acid + 231
                      butenedioic acid + 618
                      butynedioic acid + 0
                      dihydroxyfumaric acid 0
                      enol-oxaloacetic acid 0
                      iminoaspartic acid 0
                      malic acid + 97
                      methylmalonic acid + 6
                      oxaloacetic acid + 8
                      succinic acid + 653
                      succinic acid-d4 0
                      tetraric acid + 0
                      thiomalic acid + 450
                      trans-2,3-epoxysuccinic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      carbon group element atom 21915
                        carbon atom 21840
                          organic molecular entity 21840
                            organic group 20283
                              organic divalent group 20165
                                organodiyl group 20165
                                  carbonyl group 20159
                                    carbonyl compound 20159
                                      dicarboxylic acids and O-substituted derivatives 10883
                                        dicarboxylic acid 10876
                                          C4-dicarboxylic acid 1322
                                            2-chlorosuccinic acid 0
                                            2-hydroxy-3-oxosuccinic acid + 0
                                            3-hydroxyaspartic acid + 0
                                            3-methylthioaspartic acid + 0
                                            3-thio-L-aspartic acid + 0
                                            N-carbamoylaspartic acid + 0
                                            N-formimidoyl-L-aspartic acid 0
                                            aspartic acid + 231
                                            butenedioic acid + 618
                                            butynedioic acid + 0
                                            dihydroxyfumaric acid 0
                                            enol-oxaloacetic acid 0
                                            iminoaspartic acid 0
                                            malic acid + 97
                                            methylmalonic acid + 6
                                            oxaloacetic acid + 8
                                            succinic acid + 653
                                            succinic acid-d4 0
                                            tetraric acid + 0
                                            thiomalic acid + 450
                                            trans-2,3-epoxysuccinic acid 0
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