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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:C4-dicarboxylic acid
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Accession:CHEBI:66873 term browser browse the term
Definition:Any dicarboxylic acid that contains four carbon atoms.
Synonyms:related_synonym: C4-dicarboxylic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:61336


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Ac-Asp-Glu term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOLH1 folate hydrolase 1 affects binding
multiple interactions
EXP isospaglumic acid binds to FOLH1 protein
[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]
CTD PMID:24508213 NCBI chr11:49,145,092...49,208,642
Ensembl chr11:49,145,092...49,208,638
JBrowse link
artesunate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO
EXP
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]
Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein
CTD PMID:30551460 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 affects localization EXP artesunate affects the localization of AIFM1 protein CTD PMID:24704559 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G APOBEC3C apolipoprotein B mRNA editing enzyme catalytic subunit 3C multiple interactions
increases expression
increases response to substance
EXP APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein]; APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein]; APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AFX protein]
Artesunate results in increased expression of APOBEC3C mRNA; Artesunate results in increased expression of APOBEC3C protein
APOBEC3C protein results in increased susceptibility to Artesunate
CTD PMID:31664825 NCBI chr22:39,014,236...39,020,352
Ensembl chr22:39,014,257...39,020,352
JBrowse link
G AR androgen receptor multiple interactions EXP artesunate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ATG12 autophagy related 12 increases expression EXP Artesunate results in increased expression of ATG12 mRNA CTD PMID:30551460 NCBI chr 5:115,828,200...115,841,565
Ensembl chr 5:115,828,200...115,841,837
JBrowse link
G ATG3 autophagy related 3 increases expression EXP Artesunate results in increased expression of ATG3 mRNA CTD PMID:30551460 NCBI chr 3:112,532,510...112,561,962
Ensembl chr 3:112,532,510...112,562,046
JBrowse link
G ATG5 autophagy related 5 increases expression EXP Artesunate results in increased expression of ATG5 mRNA CTD PMID:30551460 NCBI chr 6:106,184,476...106,325,789
Ensembl chr 6:106,045,423...106,325,791
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP
ISO
artesunate results in increased expression of BAX protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein
CTD PMID:24704559 PMID:29031619 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP
ISO
artesunate results in decreased expression of BCL2 protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein
CTD PMID:24704559 PMID:29031619 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BST1 bone marrow stromal cell antigen 1 increases response to substance EXP BST1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 4:15,701,866...15,774,178
Ensembl chr 4:15,703,065...15,738,313
JBrowse link
G CASP3 caspase 3 increases activity EXP artesunate results in increased activity of CASP3 protein CTD PMID:19513562 PMID:24704559 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 affects expression EXP artesunate affects the expression of CASP9 protein CTD PMID:24704559 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase increases expression
decreases response to substance
EXP artesunate results in increased expression of CAT protein
CAT protein results in decreased susceptibility to artesunate
CTD PMID:19513562 PMID:20144594 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCT2 chaperonin containing TCP1 subunit 2 decreases response to substance EXP CCT2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:69,585,459...69,601,570
Ensembl chr12:69,585,426...69,601,570
JBrowse link
G CHEK1 checkpoint kinase 1 multiple interactions
increases phosphorylation
EXP APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 NCBI chr11:125,624,910...125,676,255
Ensembl chr11:125,625,665...125,676,255
JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions
increases phosphorylation
EXP APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G CLIP4 CAP-Gly domain containing linker protein family member 4 increases response to substance EXP CLIP4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:29,097,681...29,183,808
Ensembl chr 2:29,097,705...29,189,643
JBrowse link
G COQ8A coenzyme Q8A decreases response to substance EXP COQ8A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:226,939,339...226,987,544
Ensembl chr 1:226,897,536...226,987,545
Ensembl chr 1:226,897,536...226,987,545
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] CTD PMID:29031619 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 affects metabolic processing EXP CYP2A6 protein affects the metabolism of artesunate CTD PMID:12920490 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G DBH dopamine beta-hydroxylase increases response to substance EXP DBH mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329
JBrowse link
G DES desmin multiple interactions
decreases expression
EXP Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]
Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein
CTD PMID:30551460 NCBI chr 2:219,418,377...219,426,734
Ensembl chr 2:219,418,377...219,426,734
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP artesunate binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G FAS Fas cell surface death receptor increases expression EXP artesunate results in increased expression of FAS protein CTD PMID:19513562 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FLNA filamin A increases response to substance EXP FLNA mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr  X:154,348,531...154,374,634
Ensembl chr  X:154,348,524...154,374,638
Ensembl chr  X:154,348,524...154,374,638
JBrowse link
G FN1 fibronectin 1 decreases expression
multiple interactions
EXP Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA]
CTD PMID:30551460 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FTH1 ferritin heavy chain 1 decreases expression
multiple interactions
EXP Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
CTD PMID:30551460 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G FZD7 frizzled class receptor 7 increases response to substance EXP FZD7 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:202,033,855...202,038,441
Ensembl chr 2:202,034,587...202,038,445
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit affects response to substance
decreases response to substance
EXP GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate
CTD PMID:15796179 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit decreases response to substance EXP GCLM mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GPX4 glutathione peroxidase 4 decreases activity
multiple interactions
EXP
ISO
Artesunate results in decreased activity of GPX4 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]
CTD PMID:30551460 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,926...1,106,791
JBrowse link
G GSTM4 glutathione S-transferase mu 4 affects response to substance EXP GSTM4 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 1:109,656,076...109,665,497
Ensembl chr 1:109,656,099...109,674,836
JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases expression EXP artesunate results in decreased expression of GSTP1 protein CTD PMID:19513562 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) affects response to substance EXP GSTT2 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr22:23,980,134...23,983,915
Ensembl chr22:23,980,058...23,983,915
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 affects response to substance EXP GSTZ1 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr14:77,321,002...77,331,597
Ensembl chr14:77,320,996...77,331,597
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:27474069 PMID:30031708 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:27474069 PMID:30031708 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGB1 integrin subunit beta 1 increases response to substance EXP ITGB1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,900,318...33,005,792
Ensembl chr10:32,900,318...33,005,792
JBrowse link
G MGST3 microsomal glutathione S-transferase 3 affects response to substance EXP MGST3 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 1:165,631,234...165,656,136
Ensembl chr 1:165,631,213...165,661,796
JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:29031619 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO
EXP
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Artesunate results in decreased expression of MMP9 mRNA
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]
CTD PMID:29031619 PMID:30551460 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:27474069 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases response to substance EXP MTHFD2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:74,198,591...74,217,565
Ensembl chr 2:74,198,610...74,217,565
Ensembl chr 2:74,198,610...74,217,565
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] CTD PMID:30031708 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,478...38,143,022
JBrowse link
G NACA nascent polypeptide associated complex subunit alpha decreases response to substance EXP NACA mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:56,712,427...56,725,299
Ensembl chr12:56,712,427...56,731,628
Ensembl chr12:56,712,427...56,731,628
Ensembl chr12:56,712,427...56,731,628
JBrowse link
G NCKAP1 NCK associated protein 1 increases response to substance EXP NCKAP1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:182,909,115...183,038,457
Ensembl chr 2:182,909,115...183,038,858
JBrowse link
G NCOA4 nuclear receptor coactivator 4 multiple interactions
decreases expression
EXP Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein
CTD PMID:30551460 NCBI chr10:46,005,088...46,030,623
Ensembl chr10:46,005,088...46,030,714
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects localization EXP artesunate affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP artesunate results in increased cleavage of PARP1 protein CTD PMID:24704559 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29031619 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PGR progesterone receptor multiple interactions EXP artesunate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein CTD PMID:30551460 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] CTD PMID:27474069 PMID:30031708 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RPA2 replication protein A2 increases phosphorylation EXP Artesunate results in increased phosphorylation of RPA2 protein CTD PMID:31664825 NCBI chr 1:27,891,524...27,914,797
Ensembl chr 1:27,891,524...27,914,746
JBrowse link
G RPL29P2 ribosomal protein L29 pseudogene 2 decreases response to substance EXP RPL29P2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr17:7,754,320...7,754,976
Ensembl chr17:7,754,320...7,754,976
JBrowse link
G RPL41 ribosomal protein L41 decreases response to substance EXP RPL41 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:56,116,633...56,117,967
Ensembl chr12:56,116,590...56,117,967
JBrowse link
G RPL6 ribosomal protein L6 decreases response to substance EXP RPL6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:112,405,181...112,418,850
Ensembl chr12:112,405,190...112,418,838
JBrowse link
G RPL7 ribosomal protein L7 decreases response to substance EXP RPL7 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 8:73,290,242...73,294,466
Ensembl chr 8:73,290,242...73,295,789
JBrowse link
G RPS12 ribosomal protein S12 decreases response to substance EXP RPS12 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 6:132,814,569...132,817,564
Ensembl chr 6:132,814,569...132,817,564
JBrowse link
G RPS15A ribosomal protein S15a decreases response to substance EXP RPS15A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr16:18,781,295...18,790,334
Ensembl chr16:18,781,295...18,790,383
JBrowse link
G RPS6 ribosomal protein S6 decreases response to substance EXP RPS6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
G SLC25A19 solute carrier family 25 member 19 decreases response to substance EXP SLC25A19 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr17:75,272,980...75,289,958
Ensembl chr17:75,272,981...75,289,510
JBrowse link
G SP1 Sp1 transcription factor decreases expression EXP artesunate results in decreased expression of SP1 protein CTD PMID:19513562 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
decreases expression
EXP Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]
Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein
CTD PMID:30551460 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G SRSF2 serine and arginine rich splicing factor 2 decreases response to substance EXP SRSF2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr17:76,734,115...76,737,411
Ensembl chr17:76,734,115...76,737,374
Ensembl chr17:76,734,115...76,737,374
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression
EXP Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA] CTD PMID:30551460 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:27474069 PMID:30031708 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TPT1 tumor protein, translationally-controlled 1 affects response to substance EXP TPT1 protein affects the susceptibility to artesunate CTD PMID:15878303 NCBI chr13:45,333,471...45,341,183
Ensembl chr13:45,333,471...45,341,370
Ensembl chr13:45,333,471...45,341,370
JBrowse link
G TUFM Tu translation elongation factor, mitochondrial decreases response to substance EXP TUFM mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr16:28,842,411...28,846,348
Ensembl chr16:28,842,411...28,846,348
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] CTD PMID:29031619 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G YY1 YY1 transcription factor decreases expression EXP artesunate results in decreased expression of YY1 protein CTD PMID:19513562 NCBI chr14:100,239,144...100,282,788
Ensembl chr14:100,238,298...100,282,788
JBrowse link
G ZBTB4 zinc finger and BTB domain containing 4 increases response to substance EXP ZBTB4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr17:7,459,366...7,484,249
Ensembl chr17:7,459,366...7,484,263
JBrowse link
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCA1 mRNA CTD PMID:23783067 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCB4 mRNA CTD PMID:23783067 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G ABCD1 ATP binding cassette subfamily D member 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ABCD1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD1 mRNA CTD PMID:23783067 NCBI chr  X:153,724,851...153,744,755
Ensembl chr  X:153,724,856...153,744,755
JBrowse link
G ABCD2 ATP binding cassette subfamily D member 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD2 mRNA CTD PMID:23783067 NCBI chr12:39,530,965...39,651,333
Ensembl chr12:39,550,033...39,619,803
JBrowse link
G ACAA1 acetyl-CoA acyltransferase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1B mRNA CTD PMID:23783067 NCBI chr 3:38,122,710...38,137,127
Ensembl chr 3:38,103,129...38,137,242
JBrowse link
G ACACB acetyl-CoA carboxylase beta multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACACB mRNA CTD PMID:23783067 NCBI chr12:109,112,666...109,268,226
Ensembl chr12:109,116,595...109,268,226
JBrowse link
G ACADS acyl-CoA dehydrogenase short chain multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADS mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADS mRNA CTD PMID:23783067 NCBI chr12:120,725,826...120,740,008
Ensembl chr12:120,725,774...120,740,008
JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADVL mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADVL mRNA CTD PMID:23783067 NCBI chr17:7,217,125...7,225,266
Ensembl chr17:7,217,125...7,225,266
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) decreases activity EXP
ISO
Aspartame metabolite results in decreased activity of ACHE protein CTD PMID:16129618 PMID:17580119 PMID:17673349 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACO1 aconitase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACO1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACO1 mRNA CTD PMID:23783067 NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769
JBrowse link
G ACOT1 acyl-CoA thioesterase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACOT1 mRNA CTD PMID:23783067 NCBI chr14:73,493,021...73,543,799
Ensembl chr14:73,537,143...73,543,796
JBrowse link
G ADGRE1 adhesion G protein-coupled receptor E1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ADGRE1 mRNA CTD PMID:23783067 NCBI chr19:6,887,549...6,940,450
Ensembl chr19:6,887,566...6,940,459
JBrowse link
G AGT angiotensinogen decreases expression EXP Aspartame results in decreased expression of AGT mRNA CTD PMID:31655124 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AGTR1 angiotensin II receptor type 1 decreases expression EXP Aspartame results in decreased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ALOX15 mRNA CTD PMID:23783067 NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294
Ensembl chr17:4,630,919...4,642,294
JBrowse link
G APOE apolipoprotein E decreases expression EXP Aspartame results in decreased expression of APOE mRNA CTD PMID:31655124 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO [Aspartame co-treated with Methotrexate] results in increased expression of BAX mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of BAX protein
[Fats, Unsaturated co-treated with Aspartame] affects the expression of BAX mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of BAX mRNA
CTD PMID:23783067 PMID:25009784 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 mRNA; [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 protein CTD PMID:25009784 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CABP2 calcium binding protein 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CABP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CABP2 mRNA CTD PMID:23783067 NCBI chr11:67,518,912...67,523,446
Ensembl chr11:67,518,912...67,524,517
JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1A mRNA CTD PMID:23783067 NCBI chr19:13,206,442...13,506,479
Ensembl chr19:13,206,442...13,633,025
JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1I mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1I mRNA CTD PMID:23783067 NCBI chr22:39,570,753...39,689,737
Ensembl chr22:39,570,753...39,689,735
JBrowse link
G CACNA2D4 calcium voltage-gated channel auxiliary subunit alpha2delta 4 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA2D4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA2D4 mRNA CTD PMID:23783067 NCBI chr12:1,791,963...1,922,606
Ensembl chr12:1,791,963...1,918,666
JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNB2 mRNA CTD PMID:23783067 NCBI chr10:18,140,424...18,545,881
Ensembl chr10:18,140,677...18,543,557
Ensembl chr10:18,140,677...18,543,557
JBrowse link
G CACNG4 calcium voltage-gated channel auxiliary subunit gamma 4 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG4 mRNA CTD PMID:23783067 NCBI chr17:66,964,707...67,033,398
Ensembl chr17:66,964,707...67,033,398
JBrowse link
G CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG8 mRNA CTD PMID:23783067 NCBI chr19:53,962,937...53,990,215
Ensembl chr19:53,963,040...53,990,215
JBrowse link
G CALHM2 calcium homeostasis modulator family member 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CALHM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALHM2 mRNA CTD PMID:23783067 NCBI chr10:103,446,783...103,452,403
Ensembl chr10:103,446,786...103,452,402
JBrowse link
G CALR3 calreticulin 3 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CALR3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALR3 mRNA CTD PMID:23783067 NCBI chr19:16,479,061...16,496,167
Ensembl chr19:16,479,057...16,496,192
Ensembl chr19:16,479,057...16,496,192
JBrowse link
G CANT1 calcium activated nucleotidase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CANT1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CANT1 mRNA CTD PMID:23783067 NCBI chr17:78,991,716...79,009,793
Ensembl chr17:78,991,716...79,009,867
JBrowse link
G CASP3 caspase 3 multiple interactions ISO [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 protein modified form CTD PMID:25009784 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CASP9 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CASP9 mRNA CTD PMID:23783067 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions ISO [Aspartame co-treated with Methotrexate] results in increased activity of CAT protein CTD PMID:25009784 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] results in increased expression of CCL2 protein; [Sodium Glutamate co-treated with Aspartame] inhibits the reaction [Fats, Unsaturated results in increased expression of CCL2 protein] CTD PMID:23783067 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CDKN1B mRNA CTD PMID:23783067 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CHERP calcium homeostasis endoplasmic reticulum protein multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CHERP mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CHERP mRNA CTD PMID:23783067 NCBI chr19:16,517,894...16,542,437
Ensembl chr19:16,517,894...16,542,437
JBrowse link
G CMC1 C-X9-C motif containing 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CMC1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CMC1 mRNA CTD PMID:23783067 NCBI chr 3:28,241,593...28,325,142
Ensembl chr 3:28,241,584...28,325,142
JBrowse link
G COX11 cytochrome c oxidase copper chaperone COX11 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX11 mRNA CTD PMID:23783067 NCBI chr17:54,951,898...54,968,785
Ensembl chr17:54,951,902...54,968,703
Ensembl chr17:54,951,902...54,968,703
JBrowse link
G COX7A1 cytochrome c oxidase subunit 7A1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX7A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX7A1 mRNA CTD PMID:23783067 NCBI chr19:36,150,922...36,152,447
Ensembl chr19:36,150,922...36,152,449
JBrowse link
G CPT1B carnitine palmitoyltransferase 1B multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CPT1B mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1B mRNA CTD PMID:23783067 NCBI chr22:50,568,861...50,578,612
Ensembl chr22:50,568,861...50,578,465
JBrowse link
G CPT1C carnitine palmitoyltransferase 1C multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1C mRNA CTD PMID:23783067 NCBI chr19:49,690,672...49,713,731
Ensembl chr19:49,690,898...49,713,731
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CREB1 mRNA CTD PMID:23783067 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CSF1 colony stimulating factor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CSF1 mRNA CTD PMID:23783067 NCBI chr 1:109,910,506...109,930,992
Ensembl chr 1:109,910,242...109,930,992
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases activity ISO Aspartame results in increased activity of CYP1A1 protein CTD PMID:16937917 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases activity ISO Aspartame results in increased activity of CYP1A2 protein CTD PMID:16937917 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO Aspartame results in increased expression of and results in increased activity of CYP2E1 protein CTD PMID:16937917 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases activity ISO Aspartame results in increased activity of CYP3A62 protein CTD PMID:16937917 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DIABLO diablo IAP-binding mitochondrial protein multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of DIABLO mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DIABLO mRNA CTD PMID:23783067 NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,663...122,227,456
Ensembl chr12:122,207,663...122,227,456
JBrowse link
G DNAJC27 DnaJ heat shock protein family (Hsp40) member C27 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of DNAJC27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DNAJC27 mRNA CTD PMID:23783067 NCBI chr 2:24,943,636...24,972,094
Ensembl chr 2:24,943,636...24,972,094
JBrowse link
G E2F1 E2F transcription factor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of E2F1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of E2F1 mRNA CTD PMID:23783067 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G EDN2 endothelin 2 decreases expression EXP Aspartame results in decreased expression of EDN2 mRNA CTD PMID:31655124 NCBI chr 1:41,478,775...41,484,699
Ensembl chr 1:41,478,775...41,484,683
JBrowse link
G EDNRA endothelin receptor type A decreases expression EXP Aspartame results in decreased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of EHHADH mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EHHADH mRNA CTD PMID:23783067 NCBI chr 3:185,190,624...185,254,049
Ensembl chr 3:185,190,624...185,281,990
JBrowse link
G EPHX2 epoxide hydrolase 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of EPHX2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EPHX2 mRNA CTD PMID:23783067 NCBI chr 8:27,491,143...27,597,559
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
G F2 coagulation factor II, thrombin decreases activity EXP Aspartame analog results in decreased activity of F2 protein; Aspartame results in decreased activity of F2 protein CTD PMID:15572260 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G FGF1 fibroblast growth factor 1 increases expression EXP Aspartame results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
JBrowse link
G FOXO3 forkhead box O3 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of FOXO3 mRNA CTD PMID:23783067 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G GADD45B growth arrest and DNA damage inducible beta multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GADD45B mRNA CTD PMID:23783067 NCBI chr19:2,476,127...2,478,259
Ensembl chr19:2,476,122...2,478,259
JBrowse link
G GFM2 GTP dependent ribosome recycling factor mitochondrial 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of GFM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GFM2 mRNA CTD PMID:23783067 NCBI chr 5:74,721,206...74,767,147
Ensembl chr 5:74,721,206...74,767,147
JBrowse link
G GIP gastric inhibitory polypeptide multiple interactions ISO Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]; Sodium Glutamate inhibits the reaction [Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]] CTD PMID:23783067 NCBI chr17:48,958,554...48,968,596
Ensembl chr17:48,958,554...48,968,596
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO [Aspartame co-treated with Methotrexate] results in decreased activity of GSR protein CTD PMID:25009784 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HADHA hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHA mRNA CTD PMID:23783067 NCBI chr 2:26,190,635...26,244,632
Ensembl chr 2:26,190,635...26,244,672
JBrowse link
G HADHB hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHB mRNA CTD PMID:23783067 NCBI chr 2:26,244,917...26,290,465
Ensembl chr 2:26,243,170...26,290,465
JBrowse link
G HDAC1 histone deacetylase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC1 mRNA CTD PMID:23783067 NCBI chr 1:32,292,083...32,333,628
Ensembl chr 1:32,292,083...32,333,635
JBrowse link
G HDAC5 histone deacetylase 5 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC5 mRNA CTD PMID:23783067 NCBI chr17:44,076,753...44,123,651
Ensembl chr17:44,076,746...44,123,702
JBrowse link
G HGF hepatocyte growth factor multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HGF mRNA CTD PMID:23783067 NCBI chr 7:81,699,006...81,770,438
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G HRAS HRas proto-oncogene, GTPase increases expression ISO Aspartame results in increased expression of HRAS CTD PMID:17354619 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,287
JBrowse link
G HSPG2 heparan sulfate proteoglycan 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HSPG2 mRNA CTD PMID:23783067 NCBI chr 1:21,822,244...21,937,310
Ensembl chr 1:21,822,244...21,937,310
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of IDH2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IDH2 mRNA CTD PMID:23783067 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,504
Ensembl chr15:90,083,045...90,102,504
JBrowse link
G IL11 interleukin 11 decreases expression EXP Aspartame results in decreased expression of IL11 mRNA CTD PMID:31655124 NCBI chr19:55,364,382...55,370,463
Ensembl chr19:55,364,382...55,370,463
JBrowse link
G IL1B interleukin 1 beta increases expression EXP Aspartame results in increased expression of IL1B mRNA CTD PMID:31655124 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL3 interleukin 3 decreases expression EXP Aspartame results in decreased expression of IL3 mRNA CTD PMID:31655124 NCBI chr 5:132,060,655...132,063,204
Ensembl chr 5:132,060,655...132,063,204
JBrowse link
G IL6 interleukin 6 increases secretion EXP Aspartame results in increased secretion of IL6 protein CTD PMID:20837131 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IMMT inner membrane mitochondrial protein multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of IMMT mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IMMT mRNA CTD PMID:23783067 NCBI chr 2:86,143,932...86,195,463
Ensembl chr 2:86,143,932...86,195,770
Ensembl chr 2:86,143,932...86,195,770
JBrowse link
G INS insulin increases expression
multiple interactions
EXP
ISO
Aspartame results in increased expression of INS protein
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] results in increased expression of INS2 protein; Aspartame inhibits the reaction [Fats, Unsaturated results in increased expression of INS2 protein]
CTD PMID:1805284 PMID:23783067 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G KDR kinase insert domain receptor increases secretion EXP Aspartame results in increased secretion of KDR protein CTD PMID:20837131 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G LEP leptin decreases expression
multiple interactions
ISO Aspartame results in decreased expression of LEP protein
[Fats, Unsaturated co-treated with Aspartame] results in increased expression of LEP protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of LEP protein]
CTD PMID:11890951 PMID:23783067 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LIPG lipase G, endothelial type multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LIPG mRNA CTD PMID:23783067 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
G LRP1 LDL receptor related protein 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP1 mRNA CTD PMID:23783067 NCBI chr12:57,128,401...57,213,377
Ensembl chr12:57,128,483...57,213,361
JBrowse link
G LRP2 LDL receptor related protein 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP2 mRNA CTD PMID:23783067 NCBI chr 2:169,127,109...169,362,597
Ensembl chr 2:169,127,109...169,362,534
JBrowse link
G LRP4 LDL receptor related protein 4 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP4 mRNA CTD PMID:23783067 NCBI chr11:46,854,715...46,918,550
Ensembl chr11:46,856,717...46,918,642
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Aspartame results in increased phosphorylation of MAPK1 protein CTD PMID:20837131 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Aspartame results in increased phosphorylation of MAPK3 protein CTD PMID:20837131 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MCU mitochondrial calcium uniporter multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MCU mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MCU mRNA CTD PMID:23783067 NCBI chr10:72,692,131...72,887,694
Ensembl chr10:72,692,131...72,887,694
JBrowse link
G MDM2 MDM2 proto-oncogene multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA CTD PMID:23783067 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G MED23 mediator complex subunit 23 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MED23 mRNA CTD PMID:23783067 NCBI chr 6:131,573,966...131,628,313
Ensembl chr 6:131,573,966...131,628,242
JBrowse link
G MEF2D myocyte enhancer factor 2D multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MEF2D mRNA CTD PMID:23783067 NCBI chr 1:156,463,727...156,500,840
Ensembl chr 1:156,463,727...156,500,779
JBrowse link
G MICOS10 mitochondrial contact site and cristae organizing system subunit 10 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MINOS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MINOS1 mRNA CTD PMID:23783067 NCBI chr 1:19,596,979...19,629,820
Ensembl chr 1:19,484,403...19,629,821
JBrowse link
G MICU1 mitochondrial calcium uptake 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MICU1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MICU1 mRNA CTD PMID:23783067 NCBI chr10:72,367,339...72,626,096
Ensembl chr10:72,367,327...72,626,191
JBrowse link
G MRPL20 mitochondrial ribosomal protein L20 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL20 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL20 mRNA CTD PMID:23783067 NCBI chr 1:1,401,909...1,407,293
Ensembl chr 1:1,401,909...1,407,293
JBrowse link
G MRPL3 mitochondrial ribosomal protein L3 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL3 mRNA CTD PMID:23783067 NCBI chr 3:131,462,212...131,502,971
Ensembl chr 3:131,462,212...131,502,983
JBrowse link
G MRPS12 mitochondrial ribosomal protein S12 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS12 mRNA CTD PMID:23783067 NCBI chr19:38,930,944...38,933,168
Ensembl chr19:38,930,548...38,933,162
Ensembl chr19:38,930,548...38,933,162
JBrowse link
G MRPS24 mitochondrial ribosomal protein S24 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS24 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS24 mRNA CTD PMID:23783067 NCBI chr 7:43,866,558...43,869,517
Ensembl chr 7:43,866,558...43,869,893
JBrowse link
G MRPS27 mitochondrial ribosomal protein S27 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS27 mRNA CTD PMID:23783067 NCBI chr 5:72,219,403...72,320,240
Ensembl chr 5:72,219,403...72,320,646
Ensembl chr 5:72,219,403...72,320,646
JBrowse link
G MRPS7 mitochondrial ribosomal protein S7 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS7 mRNA CTD PMID:23783067 NCBI chr17:75,261,879...75,266,376
Ensembl chr17:75,261,674...75,266,376
JBrowse link
G MTFP1 mitochondrial fission process 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MTFP1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MTFP1 mRNA CTD PMID:23783067 NCBI chr22:30,425,768...30,429,054
Ensembl chr22:30,425,623...30,429,054
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression ISO Aspartame results in increased expression of MYC CTD PMID:17354619 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NCOR1 nuclear receptor corepressor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NCOR1 mRNA CTD PMID:23783067 NCBI chr17:16,029,157...16,216,475
Ensembl chr17:16,029,157...16,218,185
JBrowse link
G NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA12 mRNA CTD PMID:23783067 NCBI chr12:94,971,333...95,003,697
Ensembl chr12:94,897,055...95,003,748
JBrowse link
G NDUFA5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA5 mRNA CTD PMID:23783067 NCBI chr 7:123,536,997...123,601,651
Ensembl chr 7:123,536,997...123,557,904
JBrowse link
G NDUFB10 NADH:ubiquinone oxidoreductase subunit B10 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB10 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB10 mRNA CTD PMID:23783067 NCBI chr16:1,959,538...1,961,975
Ensembl chr16:1,959,538...1,961,975
JBrowse link
G NDUFB2 NADH:ubiquinone oxidoreductase subunit B2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB2 mRNA CTD PMID:23783067 NCBI chr 7:140,696,708...140,706,643
Ensembl chr 7:140,690,777...140,722,790
JBrowse link
G NDUFB6 NADH:ubiquinone oxidoreductase subunit B6 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB6 mRNA CTD PMID:23783067 NCBI chr 9:32,553,001...32,573,159
Ensembl chr 9:32,553,001...32,573,184
JBrowse link
G NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS1 mRNA CTD PMID:23783067 NCBI chr 2:206,114,817...206,159,444
Ensembl chr 2:206,114,817...206,159,509
JBrowse link
G NDUFS6 NADH:ubiquinone oxidoreductase subunit S6 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS6 mRNA CTD PMID:23783067 NCBI chr 5:1,801,407...1,816,048
Ensembl chr 5:1,801,400...1,816,605
Ensembl chr 5:1,801,400...1,816,605
JBrowse link
G NDUFV1 NADH:ubiquinone oxidoreductase core subunit V1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFV1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFV1 mRNA CTD PMID:23783067 NCBI chr11:67,606,936...67,612,554
Ensembl chr11:67,605,653...67,612,554
JBrowse link
G NF1 neurofibromin 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NF1 mRNA CTD PMID:23783067 NCBI chr17:31,094,927...31,377,677
Ensembl chr17:31,094,927...31,382,116
JBrowse link
G NOTCH1 notch receptor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOTCH1 mRNA CTD PMID:23783067 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G NOX1 NADPH oxidase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOX1 mRNA CTD PMID:23783067 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G NPPB natriuretic peptide B decreases expression EXP Aspartame results in decreased expression of NPPB mRNA CTD PMID:31655124 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G NPY neuropeptide Y decreases expression ISO Aspartame results in decreased expression of NPY protein CTD PMID:11890951 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NR1I3 mRNA CTD PMID:23783067 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
G ONECUT1 one cut homeobox 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ONECUT1 mRNA CTD PMID:23783067 NCBI chr15:52,755,053...52,790,336
Ensembl chr15:52,755,053...52,791,078
JBrowse link
G PDHA2 pyruvate dehydrogenase E1 subunit alpha 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHA2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHA2 mRNA CTD PMID:23783067 NCBI chr 4:95,840,093...95,841,464
Ensembl chr 4:95,840,093...95,841,464
JBrowse link
G PDHB pyruvate dehydrogenase E1 subunit beta multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHB mRNA CTD PMID:23783067 NCBI chr 3:58,427,630...58,433,832
Ensembl chr 3:58,427,630...58,433,857
JBrowse link
G PEX1 peroxisomal biogenesis factor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX1 mRNA CTD PMID:23783067 NCBI chr 7:92,487,023...92,528,520
Ensembl chr 7:92,487,020...92,528,520
JBrowse link
G PEX11A peroxisomal biogenesis factor 11 alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX11A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX11A mRNA CTD PMID:23783067 NCBI chr15:89,681,535...89,690,754
Ensembl chr15:89,677,764...89,690,783
JBrowse link
G PEX13 peroxisomal biogenesis factor 13 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX13 mRNA CTD PMID:23783067 NCBI chr 2:61,017,720...61,051,990
Ensembl chr 2:61,017,225...61,051,990
JBrowse link
G PEX5 peroxisomal biogenesis factor 5 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX5 mRNA CTD PMID:23783067 NCBI chr12:7,188,653...7,218,574
Ensembl chr12:7,188,685...7,218,574
JBrowse link
G PEX7 peroxisomal biogenesis factor 7 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX7 mRNA CTD PMID:23783067 NCBI chr 6:136,821,683...136,913,934
Ensembl chr 6:136,822,564...136,913,934
JBrowse link
G PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB2 mRNA CTD PMID:23783067 NCBI chr 1:207,053,063...207,081,027
Ensembl chr 1:207,034,366...207,081,024
JBrowse link
G PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB4 mRNA CTD PMID:23783067 NCBI chr 3:48,517,684...48,562,383
Ensembl chr 3:48,517,684...48,562,015
JBrowse link
G PLD2 phospholipase D2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLD2 mRNA CTD PMID:23783067 NCBI chr17:4,807,152...4,823,432
Ensembl chr17:4,807,152...4,823,434
JBrowse link
G PLG plasminogen decreases expression EXP Aspartame results in decreased expression of PLG mRNA CTD PMID:31655124 NCBI chr 6:160,702,193...160,754,097
Ensembl chr 6:160,702,238...160,754,097
Ensembl chr 6:160,702,238...160,754,097
JBrowse link
G PLXND1 plexin D1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLXND1 mRNA CTD PMID:23783067 NCBI chr 3:129,555,214...129,606,676
Ensembl chr 3:129,555,214...129,606,676
Ensembl chr 3:129,555,214...129,606,676
JBrowse link
G POLG DNA polymerase gamma, catalytic subunit multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of POLG mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of POLG mRNA CTD PMID:23783067 NCBI chr15:89,316,320...89,334,824
Ensembl chr15:89,305,198...89,334,861
JBrowse link
G POMC proopiomelanocortin increases expression EXP Aspartame results in increased expression of POMC protein alternative form CTD PMID:1805284 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARA mRNA CTD PMID:23783067 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARD peroxisome proliferator activated receptor delta multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARD mRNA CTD PMID:23783067 NCBI chr 6:35,342,558...35,428,180
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARG mRNA CTD PMID:23783067 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARGC1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARGC1A mRNA CTD PMID:23783067 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRDX5 peroxiredoxin 5 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PRDX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PRDX5 mRNA CTD PMID:23783067 NCBI chr11:64,318,121...64,321,811
Ensembl chr11:64,318,121...64,321,811
JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ROCK1 mRNA CTD PMID:23783067 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,946,906...21,111,813
JBrowse link
G S100A13 S100 calcium binding protein A13 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A13 mRNA CTD PMID:23783067 NCBI chr 1:153,618,799...153,634,361
Ensembl chr 1:153,618,787...153,631,360
JBrowse link
G S100A8 S100 calcium binding protein A8 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A8 mRNA CTD PMID:23783067 NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073
JBrowse link
G SDHB succinate dehydrogenase complex iron sulfur subunit B multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of SDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SDHB mRNA CTD PMID:23783067 NCBI chr 1:17,018,722...17,054,032
Ensembl chr 1:17,018,722...17,054,032
Ensembl chr 1:17,018,722...17,054,032
JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT1 mRNA CTD PMID:23783067 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SIRT2 sirtuin 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA CTD PMID:23783067 NCBI chr19:38,878,555...38,899,733
Ensembl chr19:38,878,555...38,899,862
JBrowse link
G SLC15A1 solute carrier family 15 member 1 decreases activity EXP Aspartame results in decreased activity of SLC15A1 protein CTD PMID:15846457 NCBI chr13:98,683,801...98,752,672
Ensembl chr13:98,683,801...98,752,672
JBrowse link
G SLC4A2 solute carrier family 4 member 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC4A2 mRNA CTD PMID:23783067 NCBI chr 7:151,058,200...151,076,527
Ensembl chr 7:151,057,210...151,076,526
JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of SLC8A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC8A1 mRNA CTD PMID:23783067 NCBI chr 2:40,094,523...40,512,452
Ensembl chr 2:40,097,270...40,611,053
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SREBF2 mRNA CTD PMID:23783067 NCBI chr22:41,833,105...41,907,308
Ensembl chr22:41,833,079...41,907,307
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of STAT3 mRNA CTD PMID:23783067 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
JBrowse link
G SURF1 SURF1 cytochrome c oxidase assembly factor multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of SURF1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SURF1 mRNA CTD PMID:23783067 NCBI chr 9:133,351,758...133,356,487
Ensembl chr 9:133,351,758...133,356,676
JBrowse link
G TAS1R2 taste 1 receptor member 2 multiple interactions
affects binding
EXP Aspartame binds to and results in increased activity of TAS1R2 protein; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]; Aspartame binds to TAS1R2 protein
CTD PMID:15353592 PMID:17168764 PMID:17935609 PMID:20173092 NCBI chr 1:18,839,599...18,859,660
Ensembl chr 1:18,839,599...18,859,682
JBrowse link
G TAS1R3 taste 1 receptor member 3 affects binding
multiple interactions
EXP Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]
lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
CTD PMID:17168764 PMID:17935609 NCBI chr 1:1,331,280...1,335,320
Ensembl chr 1:1,331,280...1,335,314
JBrowse link
G TFAM transcription factor A, mitochondrial multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of TFAM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TFAM mRNA CTD PMID:23783067 NCBI chr10:58,385,409...58,399,220
Ensembl chr10:58,385,345...58,399,220
JBrowse link
G THBS1 thrombospondin 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of THBS1 mRNA CTD PMID:23783067 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] results in increased expression of TNF protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of TNF protein] CTD PMID:23783067 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
ISO Aspartame results in increased expression of TRP53
[Fats, Unsaturated co-treated with Aspartame] affects the expression of TRP53 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TRP53 mRNA
CTD PMID:17354619 PMID:23783067 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 increases activity EXP Aspartame results in increased activity of TRPV1 protein CTD PMID:17567713 PMID:18804451 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G TUFM Tu translation elongation factor, mitochondrial multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of TUFM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TUFM mRNA CTD PMID:23783067 NCBI chr16:28,842,411...28,846,348
Ensembl chr16:28,842,411...28,846,348
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of UCP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UCP2 mRNA CTD PMID:23783067 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,983,246
Ensembl chr11:73,974,672...73,983,246
JBrowse link
G UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of UQCR11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UQCR11 mRNA CTD PMID:23783067 NCBI chr19:1,597,169...1,605,462
Ensembl chr19:1,597,169...1,605,473
JBrowse link
G VEGFA vascular endothelial growth factor A increases secretion EXP Aspartame results in increased secretion of VEGFA protein CTD PMID:20837131 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of XDH mRNA CTD PMID:23783067 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
citraconic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BACH1 BTB domain and CNC homolog 1 affects localization EXP citraconic acid affects the localization of BACH1 protein CTD PMID:27277809 NCBI chr21:29,298,922...29,361,894
Ensembl chr21:29,194,071...29,630,751
JBrowse link
G FOXM1 forkhead box M1 increases expression EXP citraconic acid results in increased expression of FOXM1 protein CTD PMID:28289076 NCBI chr12:2,857,680...2,877,174
Ensembl chr12:2,857,681...2,877,155
Ensembl chr12:2,857,681...2,877,155
JBrowse link
G FTH1 ferritin heavy chain 1 increases expression EXP citraconic acid results in increased expression of FTH1 protein CTD PMID:28289076 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G FTL ferritin light chain increases expression
multiple interactions
EXP citraconic acid results in increased expression of FTL protein
citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein]
CTD PMID:28289076 NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression ISO citraconic acid results in increased expression of GCLC protein
citraconic acid results in increased expression of GCLC mRNA
CTD PMID:27277809 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression ISO citraconic acid results in increased expression of GCLM mRNA
citraconic acid results in increased expression of GCLM protein
CTD PMID:27277809 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GSR glutathione-disulfide reductase increases expression ISO citraconic acid results in increased expression of GSR mRNA
citraconic acid results in increased expression of GSR protein
CTD PMID:27277809 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HCAR2 hydroxycarboxylic acid receptor 2 multiple interactions EXP citraconic acid binds to and results in increased activity of HCAR2 protein CTD PMID:18722346 NCBI chr12:122,701,293...122,703,357
Ensembl chr12:122,701,293...122,703,357
JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO citraconic acid results in increased expression of HMOX1 mRNA
citraconic acid results in increased expression of HMOX1 mRNA; citraconic acid results in increased expression of HMOX1 protein
CTD PMID:27277809 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G MT-CYB mitochondrially encoded cytochrome b multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA] CTD PMID:27277809 NCBI chr MT:14,747...15,887
Ensembl chr MT:14,747...15,887
JBrowse link
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA] CTD PMID:27277809 NCBI chr MT:3,307...4,262
Ensembl chr MT:3,307...4,262
JBrowse link
G MT-ND5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 increases expression
multiple interactions
ISO citraconic acid results in increased expression of ND5 mRNA
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA]
CTD PMID:27277809 NCBI chr MT:12,337...14,148
Ensembl chr MT:12,337...14,148
JBrowse link
G MT-ND6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA] CTD PMID:27277809 NCBI chr MT:14,149...14,673
Ensembl chr MT:14,149...14,673
JBrowse link
G MTERF1 mitochondrial transcription termination factor 1 increases expression ISO citraconic acid results in increased expression of MTERF1A mRNA CTD PMID:27277809 NCBI chr 7:91,870,929...91,880,733
Ensembl chr 7:91,692,008...91,880,702
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
affects localization
EXP
ISO
citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein]
citraconic acid affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA]
CTD PMID:27277809 PMID:28289076 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO citraconic acid results in increased expression of NQO1 mRNA; citraconic acid results in increased expression of NQO1 protein CTD PMID:27277809 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G POLRMT RNA polymerase mitochondrial multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA] CTD PMID:27277809 NCBI chr19:617,221...633,557
Ensembl chr19:617,221...633,537
JBrowse link
diethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases cleavage EXP diethyl fumarate results in increased cleavage of CASP3 protein CTD PMID:21105742 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP diethyl fumarate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G SPTAN1 spectrin alpha, non-erythrocytic 1 increases cleavage EXP diethyl fumarate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 9:128,552,564...128,633,662
Ensembl chr 9:128,552,558...128,633,662
JBrowse link
diethyl malate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle affects expression ISO diethyl malate affects the expression of ACTA2 mRNA CTD PMID:24814887 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ACTC1 actin alpha cardiac muscle 1 affects expression ISO diethyl malate affects the expression of ACTC1 mRNA CTD PMID:24814887 NCBI chr15:34,790,230...34,795,549
Ensembl chr15:34,790,230...34,795,549
JBrowse link
G ACTN3 actinin alpha 3 affects expression ISO diethyl malate affects the expression of ACTN3 mRNA CTD PMID:24814887 NCBI chr11:66,546,395...66,563,334
Ensembl chr11:66,546,395...66,563,334
JBrowse link
G ADCY1 adenylate cyclase 1 affects expression ISO diethyl malate affects the expression of ADCY1 mRNA CTD PMID:24814887 NCBI chr 7:45,574,140...45,723,116
Ensembl chr 7:45,574,140...45,723,116
JBrowse link
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide affects expression ISO diethyl malate affects the expression of ADH1 mRNA CTD PMID:24814887 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746
JBrowse link
G AGT angiotensinogen affects expression ISO diethyl malate affects the expression of AGT mRNA CTD PMID:24814887 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G C3 complement C3 affects expression ISO diethyl malate affects the expression of C3 mRNA CTD PMID:24814887 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 affects expression ISO diethyl malate affects the expression of CACNB2 mRNA CTD PMID:24814887 NCBI chr10:18,140,424...18,545,881
Ensembl chr10:18,140,677...18,543,557
Ensembl chr10:18,140,677...18,543,557
JBrowse link
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 affects expression ISO diethyl malate affects the expression of CACNB4 mRNA CTD PMID:24814887 NCBI chr 2:151,832,771...152,099,167
Ensembl chr 2:151,832,768...152,099,475
Ensembl chr 2:151,832,768...152,099,475
Ensembl chr 2:151,832,768...152,099,475
JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA] CTD PMID:24814887 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,291
JBrowse link
G CCL20 C-C motif chemokine ligand 20 affects expression ISO diethyl malate affects the expression of CCL20 mRNA CTD PMID:24814887 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
JBrowse link
G CCL23 C-C motif chemokine ligand 23 affects expression ISO diethyl malate affects the expression of CCL6 mRNA CTD PMID:24814887 NCBI chr17:36,013,056...36,018,179
Ensembl chr17:36,013,056...36,017,972
JBrowse link
G CCL7 C-C motif chemokine ligand 7 affects expression ISO diethyl malate affects the expression of CCL7 mRNA CTD PMID:24814887 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242
JBrowse link
G COL11A1 collagen type XI alpha 1 chain affects expression ISO diethyl malate affects the expression of COL11A1 mRNA CTD PMID:24814887 NCBI chr 1:102,876,473...103,108,580
Ensembl chr 1:102,876,467...103,108,872
JBrowse link
G COL2A1 collagen type II alpha 1 chain affects expression ISO diethyl malate affects the expression of COL2A1 mRNA CTD PMID:24814887 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G COL3A1 collagen type III alpha 1 chain affects expression ISO diethyl malate affects the expression of COL3A1 mRNA CTD PMID:24814887 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
JBrowse link
G COL6A1 collagen type VI alpha 1 chain affects expression ISO diethyl malate affects the expression of COL6A1 mRNA CTD PMID:24814887 NCBI chr21:45,981,770...46,005,048
Ensembl chr21:45,981,769...46,005,050
Ensembl chr21:45,981,769...46,005,050
JBrowse link
G COMP cartilage oligomeric matrix protein affects expression ISO diethyl malate affects the expression of COMP mRNA CTD PMID:24814887 NCBI chr19:18,782,773...18,791,305
Ensembl chr19:18,782,773...18,791,305
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 affects expression ISO diethyl malate affects the expression of CXCL1 mRNA CTD PMID:24814887 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 affects expression
multiple interactions
ISO diethyl malate affects the expression of CXCL12 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA]
CTD PMID:24814887 NCBI chr10:44,292,088...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 affects expression ISO diethyl malate affects the expression of CXCL5 mRNA CTD PMID:24814887 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 affects expression ISO diethyl malate affects the expression of CYP2J9 mRNA CTD PMID:24814887 NCBI chr 1:59,893,308...59,926,773
Ensembl chr 1:59,893,308...59,926,773
JBrowse link
G DAPK2 death associated protein kinase 2 affects expression ISO diethyl malate affects the expression of DAPK2 mRNA CTD PMID:24814887 NCBI chr15:63,907,036...64,046,485
Ensembl chr15:63,907,036...64,072,033
JBrowse link
G DDX58 DExD/H-box helicase 58 affects expression ISO diethyl malate affects the expression of DDX58 mRNA CTD PMID:24814887 NCBI chr 9:32,455,302...32,526,196
Ensembl chr 9:32,455,302...32,526,208
JBrowse link
G DHRS3 dehydrogenase/reductase 3 affects expression ISO diethyl malate affects the expression of DHRS3 mRNA CTD PMID:24814887 NCBI chr 1:12,567,910...12,618,210
Ensembl chr 1:12,567,910...12,618,210
JBrowse link
G DHX58 DExH-box helicase 58 affects expression ISO diethyl malate affects the expression of DHX58 mRNA CTD PMID:24814887 NCBI chr17:42,101,404...42,112,721
Ensembl chr17:42,101,404...42,112,714
JBrowse link
G EDAR ectodysplasin A receptor affects expression ISO diethyl malate affects the expression of EDAR mRNA CTD PMID:24814887 NCBI chr 2:108,894,471...108,989,256
Ensembl chr 2:108,894,471...108,989,372
JBrowse link
G EDNRA endothelin receptor type A affects expression ISO diethyl malate affects the expression of EDNRA mRNA CTD PMID:24814887 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G EPAS1 endothelial PAS domain protein 1 affects expression ISO diethyl malate affects the expression of EPAS1 mRNA CTD PMID:24814887 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697
JBrowse link
G EPHA7 EPH receptor A7 affects expression ISO diethyl malate affects the expression of EPHA7 mRNA CTD PMID:24814887 NCBI chr 6:93,240,020...93,419,584
Ensembl chr 6:93,240,020...93,419,559
JBrowse link
G EPHB2 EPH receptor B2 affects expression ISO diethyl malate affects the expression of EPHB2 mRNA CTD PMID:24814887 NCBI chr 1:22,710,770...22,921,500
Ensembl chr 1:22,710,839...22,921,500
JBrowse link
G EPHB6 EPH receptor B6 affects expression ISO diethyl malate affects the expression of EPHB6 mRNA CTD PMID:24814887 NCBI chr 7:142,854,639...142,871,093
Ensembl chr 7:142,855,061...142,871,094
JBrowse link
G FGF10 fibroblast growth factor 10 affects expression ISO diethyl malate affects the expression of FGF10 mRNA CTD PMID:24814887 NCBI chr 5:44,300,247...44,389,706
Ensembl chr 5:44,300,247...44,389,706
Ensembl chr 5:44,300,247...44,389,706
JBrowse link
G FGF18 fibroblast growth factor 18 multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA] CTD PMID:24814887 NCBI chr 5:171,419,647...171,457,626
Ensembl chr 5:171,419,647...171,457,626
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 affects expression ISO diethyl malate affects the expression of FGFR2 mRNA CTD PMID:24814887 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,334...121,598,458
Ensembl chr10:121,478,334...121,598,458
JBrowse link
G FST follistatin affects expression ISO diethyl malate affects the expression of FST mRNA CTD PMID:24814887 NCBI chr 5:53,480,338...53,487,134
Ensembl chr 5:53,480,626...53,487,134
JBrowse link
G FZD2 frizzled class receptor 2 affects expression ISO diethyl malate affects the expression of FZD2 mRNA CTD PMID:24814887 NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262
JBrowse link
G FZD7 frizzled class receptor 7 affects expression ISO diethyl malate affects the expression of FZD7 mRNA CTD PMID:24814887 NCBI chr 2:202,033,855...202,038,441
Ensembl chr 2:202,034,587...202,038,445
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit affects expression ISO diethyl malate affects the expression of GCLC mRNA CTD PMID:24814887 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA] CTD PMID:24814887 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GGT6 gamma-glutamyltransferase 6 affects expression ISO diethyl malate affects the expression of GGT6 mRNA CTD PMID:24814887 NCBI chr17:4,556,927...4,560,920
Ensembl chr17:4,556,927...4,560,818
JBrowse link
G GLI2 GLI family zinc finger 2 affects expression ISO diethyl malate affects the expression of GLI2 mRNA CTD PMID:24814887 NCBI chr 2:120,735,868...120,992,653
Ensembl chr 2:120,735,623...120,992,653
JBrowse link
G GNAO1 G protein subunit alpha o1 affects expression ISO diethyl malate affects the expression of GNAO1 mRNA CTD PMID:24814887 NCBI chr16:56,191,489...56,357,444
Ensembl chr16:56,191,390...56,357,444
Ensembl chr16:56,191,390...56,357,444
JBrowse link
G GNG7 G protein subunit gamma 7 affects expression ISO diethyl malate affects the expression of GNG7 mRNA CTD PMID:24814887 NCBI chr19:2,511,219...2,702,694
Ensembl chr19:2,511,219...2,702,694
JBrowse link
G GSR glutathione-disulfide reductase affects expression ISO diethyl malate affects the expression of GSR mRNA CTD PMID:24814887 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSS glutathione synthetase multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA] CTD PMID:24814887 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
JBrowse link
G GSTA3 glutathione S-transferase alpha 3 affects expression
multiple interactions
ISO diethyl malate affects the expression of GSTA3 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA3 mRNA]
CTD PMID:24814887 NCBI chr 6:52,896,646...52,909,799
Ensembl chr 6:52,896,639...52,909,698
JBrowse link
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 affects expression ISO diethyl malate affects the expression of GUCY1A1 mRNA CTD PMID:24814887 NCBI chr 4:155,666,725...155,737,059
Ensembl chr 4:155,666,726...155,737,059
Ensembl chr 4:155,666,726...155,737,059
JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 affects expression ISO diethyl malate affects the expression of GUCY1B1 mRNA CTD PMID:24814887 NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811
Ensembl chr 4:155,758,992...155,807,811
JBrowse link
G HCK HCK proto-oncogene, Src family tyrosine kinase affects expression ISO diethyl malate affects the expression of HCK mRNA CTD PMID:24814887 NCBI chr20:32,052,242...32,101,856
Ensembl chr20:32,052,197...32,101,856
Ensembl chr20:32,052,197...32,101,856
JBrowse link
G HGF hepatocyte growth factor affects expression ISO diethyl malate affects the expression of HGF mRNA CTD PMID:24814887 NCBI chr 7:81,699,006...81,770,438
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G HLA-DMB major histocompatibility complex, class II, DM beta affects expression ISO diethyl malate affects the expression of H2-DMB1 mRNA CTD PMID:24814887 NCBI chr 6:32,934,636...32,941,028
Ensembl chr 6:32,934,629...32,941,028
JBrowse link
G HLA-G major histocompatibility complex, class I, G affects expression ISO diethyl malate affects the expression of H2-M3 mRNA CTD PMID:24814887 NCBI chr 6:29,826,474...29,831,130
Ensembl chr 6:29,826,967...29,831,125
JBrowse link
G IGF1 insulin like growth factor 1 affects expression ISO diethyl malate affects the expression of IGF1 mRNA CTD PMID:24814887 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IL15 interleukin 15 affects expression ISO diethyl malate affects the expression of IL15 mRNA CTD PMID:24814887 NCBI chr 4:141,636,583...141,733,987
Ensembl chr 4:141,636,583...141,733,987
JBrowse link
G IL18 interleukin 18 affects expression ISO diethyl malate affects the expression of IL18 mRNA CTD PMID:24814887 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IRAG1 inositol 1,4,5-triphosphate receptor associated 1 affects expression ISO diethyl malate affects the expression of IRAG1 mRNA CTD PMID:24814887 NCBI chr11:10,573,095...10,693,755
Ensembl chr11:10,573,091...10,693,988
JBrowse link
G IRF7 interferon regulatory factor 7 affects expression ISO diethyl malate affects the expression of IRF7 mRNA CTD PMID:24814887 NCBI chr11:612,555...615,999
Ensembl chr11:612,553...615,983
JBrowse link
G ISG15 ISG15 ubiquitin like modifier affects expression ISO diethyl malate affects the expression of ISG15 mRNA CTD PMID:24814887 NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540
JBrowse link
G ITGA11 integrin subunit alpha 11 affects expression ISO diethyl malate affects the expression of ITGA11 mRNA CTD PMID:24814887 NCBI chr15:68,296,532...68,432,312
Ensembl chr15:68,296,532...68,432,163
JBrowse link
G ITGA3 integrin subunit alpha 3 affects expression ISO diethyl malate affects the expression of ITGA3 mRNA CTD PMID:24814887 NCBI chr17:50,056,065...50,090,481
Ensembl chr17:50,055,968...50,090,481
JBrowse link
G KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 affects expression ISO diethyl malate affects the expression of KCNMB4 mRNA CTD PMID:24814887 NCBI chr12:70,366,220...70,434,292
Ensembl chr12:70,366,290...70,434,292
JBrowse link
G LAMA1 laminin subunit alpha 1 affects expression ISO diethyl malate affects the expression of LAMA1 mRNA CTD PMID:24814887 NCBI chr18:6,941,742...7,117,797
Ensembl chr18:6,941,742...7,117,797
JBrowse link
G LAMA4 laminin subunit alpha 4 affects expression ISO diethyl malate affects the expression of LAMA4 mRNA CTD PMID:24814887 NCBI chr 6:112,107,931...112,254,722
Ensembl chr 6:112,107,931...112,254,939
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 affects phosphorylation
multiple interactions
ISO diethyl malate affects the phosphorylation of MAPK1 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein]
CTD PMID:24814887 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 affects phosphorylation
multiple interactions
ISO diethyl malate affects the phosphorylation of MAPK3 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein]
CTD PMID:24814887 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MYL9 myosin light chain 9 affects expression ISO diethyl malate affects the expression of MYL9 mRNA CTD PMID:24814887 NCBI chr20:36,541,519...36,551,447
Ensembl chr20:36,541,497...36,551,447
JBrowse link
G ODC1 ornithine decarboxylase 1 affects expression ISO diethyl malate affects the expression of ODC1 mRNA CTD PMID:24814887 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G PDGFB platelet derived growth factor subunit B affects expression
multiple interactions
ISO diethyl malate affects the expression of PDGFB mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]
CTD PMID:24814887 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
G PDGFD platelet derived growth factor D affects expression ISO diethyl malate affects the expression of PDGFD mRNA CTD PMID:24814887 NCBI chr11:103,907,189...104,164,147
Ensembl chr11:103,907,189...104,164,379
JBrowse link
G PF4 platelet factor 4 affects expression ISO diethyl malate affects the expression of PF4 mRNA CTD PMID:24814887 NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027
JBrowse link
G PIK3IP1 phosphoinositide-3-kinase interacting protein 1 affects expression ISO diethyl malate affects the expression of PIK3IP1 mRNA CTD PMID:24814887 NCBI chr22:31,281,593...31,292,534
Ensembl chr22:31,281,594...31,292,534
JBrowse link
G PLXNC1 plexin C1 affects expression ISO diethyl malate affects the expression of PLXNC1 mRNA CTD PMID:24814887 NCBI chr12:94,148,577...94,307,675
Ensembl chr12:94,148,577...94,307,675
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 affects expression ISO diethyl malate affects the expression of PRKG1 mRNA CTD PMID:24814887 NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423
JBrowse link
G PTGIS prostaglandin I2 synthase affects expression ISO diethyl malate affects the expression of PTGIS mRNA CTD PMID:24814887 NCBI chr20:49,503,874...49,568,137
Ensembl chr20:49,503,874...49,568,137
JBrowse link
G RAMP2 receptor activity modifying protein 2 affects expression ISO diethyl malate affects the expression of RAMP2 mRNA CTD PMID:24814887 NCBI chr17:42,761,227...42,763,041
Ensembl chr17:42,758,447...42,763,041
JBrowse link
G RGS3 regulator of G protein signaling 3 affects expression ISO diethyl malate affects the expression of RGS3 mRNA CTD PMID:24814887 NCBI chr 9:113,444,730...113,597,743
Ensembl chr 9:113,444,731...113,597,743
JBrowse link
G RUNX1T1 RUNX1 partner transcriptional co-repressor 1 affects expression ISO diethyl malate affects the expression of RUNX1T1 mRNA CTD PMID:24814887 NCBI chr 8:91,954,967...92,103,451
Ensembl chr 8:91,954,967...92,103,286
JBrowse link
G SEMA3B semaphorin 3B affects expression ISO diethyl malate affects the expression of SEMA3B mRNA CTD PMID:24814887 NCBI chr 3:50,267,652...50,277,546
Ensembl chr 3:50,267,558...50,277,546
JBrowse link
G SEMA4G semaphorin 4G affects expression ISO diethyl malate affects the expression of SEMA4G mRNA CTD PMID:24814887 NCBI chr10:100,969,503...100,985,618
Ensembl chr10:100,969,518...100,985,871
JBrowse link
G SEMA5A semaphorin 5A affects expression ISO diethyl malate affects the expression of SEMA5A mRNA CTD PMID:24814887 NCBI chr 5:9,035,030...9,546,121
Ensembl chr 5:9,035,033...9,546,075
JBrowse link
G STAT1 signal transducer and activator of transcription 1 affects expression ISO diethyl malate affects the expression of STAT1 mRNA CTD PMID:24814887 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G TGFB2 transforming growth factor beta 2 affects expression
multiple interactions
ISO diethyl malate affects the expression of TGFB2 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]
CTD PMID:24814887 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G THBS1 thrombospondin 1 affects expression ISO diethyl malate affects the expression of THBS1 mRNA CTD PMID:24814887 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
G THBS2 thrombospondin 2 affects expression ISO diethyl malate affects the expression of THBS2 mRNA CTD PMID:24814887 NCBI chr 6:169,215,785...169,253,846
Ensembl chr 6:169,215,780...169,254,044
Ensembl chr 6:169,215,780...169,254,044
JBrowse link
G TNC tenascin C affects expression ISO diethyl malate affects the expression of TNC mRNA CTD PMID:24814887 NCBI chr 9:115,019,575...115,118,244
Ensembl chr 9:115,019,575...115,118,257
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b affects expression ISO diethyl malate affects the expression of TNFRSF11B mRNA CTD PMID:24814887 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885
JBrowse link
G TNNT1 troponin T1, slow skeletal type affects expression ISO diethyl malate affects the expression of TNNT1 mRNA CTD PMID:24814887 NCBI chr19:55,132,698...55,149,332
Ensembl chr19:55,132,698...55,149,206
JBrowse link
G TSLP thymic stromal lymphopoietin affects expression ISO diethyl malate affects the expression of TSLP mRNA CTD PMID:24814887 NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026
JBrowse link
diethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 increases expression ISO diethyl maleate results in increased expression of ABCC2 mRNA CTD PMID:25270620 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABHD4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO diethyl maleate results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr14:22,598,238...22,612,864
Ensembl chr14:22,598,237...22,613,215
JBrowse link
G ACACA acetyl-CoA carboxylase alpha decreases expression ISO diethyl maleate results in decreased expression of ACACA mRNA CTD PMID:25270620 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions ISO diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]] CTD PMID:17134953 NCBI chr17:75,941,507...75,979,199
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G ACY3 aminoacylase 3 decreases expression ISO diethyl maleate results in decreased expression of ACY3 mRNA CTD PMID:21161181 NCBI chr11:67,642,551...67,650,829
Ensembl chr11:67,642,555...67,650,730
JBrowse link
G ADORA3 adenosine A3 receptor decreases expression ISO diethyl maleate results in decreased expression of ADORA3 mRNA CTD PMID:21161181 NCBI chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
JBrowse link
G AFP alpha fetoprotein increases expression ISO diethyl maleate results in increased expression of AFP mRNA CTD PMID:25270620 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G AHCYL1 adenosylhomocysteinase like 1 increases expression ISO diethyl maleate results in increased expression of AHCYL1 mRNA CTD PMID:25270620 NCBI chr 1:109,984,765...110,023,742
Ensembl chr 1:109,984,765...110,023,742
JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 increases expression ISO diethyl maleate results in increased expression of AKR1A1 protein CTD PMID:21161181 NCBI chr 1:45,550,779...45,570,051
Ensembl chr 1:45,550,543...45,570,049
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 increases expression EXP diethyl maleate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,400...5,018,031
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 affects reduction ISO diethyl maleate affects the reduction of ALDH1A1 protein CTD PMID:19843705 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G ALDH1B1 aldehyde dehydrogenase 1 family member B1 decreases expression ISO diethyl maleate results in decreased expression of ALDH1B1 mRNA CTD PMID:21161181 NCBI chr 9:38,392,702...38,398,665
Ensembl chr 9:38,392,702...38,398,661
JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member decreases reduction
increases expression
decreases expression
ISO diethyl maleate results in decreased reduction of ALDH2 protein
diethyl maleate results in increased expression of ALDH2 protein
diethyl maleate results in decreased expression of ALDH2 protein
CTD PMID:19843705 PMID:21161181 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
JBrowse link
G ALDOB aldolase, fructose-bisphosphate B decreases expression ISO diethyl maleate results in decreased expression of ALDOB protein CTD PMID:21161181 NCBI chr 9:101,420,560...101,435,774
Ensembl chr 9:101,420,560...101,449,664
JBrowse link
G AMIGO2 adhesion molecule with Ig like domain 2 decreases expression ISO diethyl maleate results in decreased expression of AMIGO2 mRNA CTD PMID:21161181 NCBI chr12:47,075,707...47,079,959
Ensembl chr12:47,075,707...47,079,951
Ensembl chr12:47,075,707...47,079,951
JBrowse link
G ANGPTL2 angiopoietin like 2 decreases expression ISO diethyl maleate results in decreased expression of ANGPTL2 mRNA CTD PMID:21161181 NCBI chr 9:127,087,348...127,122,684
Ensembl chr 9:127,087,348...127,122,635
JBrowse link
G ANKRD46 ankyrin repeat domain 46 decreases expression ISO diethyl maleate results in decreased expression of ANKRD46 mRNA CTD PMID:21161181 NCBI chr 8:100,509,752...100,559,759
Ensembl chr 8:100,509,752...100,559,784
JBrowse link
G ANLN anillin actin binding protein increases expression ISO diethyl maleate results in increased expression of ANLN mRNA CTD PMID:21161181 NCBI chr 7:36,389,809...36,453,791
Ensembl chr 7:36,389,821...36,453,791
JBrowse link
G ANXA3 annexin A3 decreases expression ISO diethyl maleate results in decreased expression of ANXA3 mRNA CTD PMID:21161181 NCBI chr 4:78,551,761...78,610,447
Ensembl chr 4:78,551,747...78,610,451
JBrowse link
G AP3M2 adaptor related protein complex 3 subunit mu 2 decreases expression ISO diethyl maleate results in decreased expression of AP3M2 mRNA CTD PMID:21161181 NCBI chr 8:42,153,035...42,171,183
Ensembl chr 8:42,152,946...42,171,673
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression EXP diethyl maleate results in increased expression of APAF1 mRNA CTD PMID:11875189 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
JBrowse link
G APLP1 amyloid beta precursor like protein 1 decreases expression ISO diethyl maleate results in decreased expression of APLP1 mRNA CTD PMID:25270620 NCBI chr19:35,868,570...35,879,795
Ensembl chr19:35,867,899...35,879,791
Ensembl chr19:35,867,899...35,879,791
JBrowse link
G ARRDC2 arrestin domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of ARRDC2 mRNA CTD PMID:21161181 NCBI chr19:18,001,124...18,014,102
Ensembl chr19:18,001,132...18,014,102
JBrowse link
G ARRDC4 arrestin domain containing 4 decreases expression ISO diethyl maleate results in decreased expression of ARRDC4 mRNA CTD PMID:25270620 NCBI chr15:97,960,703...97,973,833
Ensembl chr15:97,960,703...97,973,833
JBrowse link
G ASF1B anti-silencing function 1B histone chaperone increases expression ISO diethyl maleate results in increased expression of ASF1B mRNA CTD PMID:21161181 NCBI chr19:14,119,512...14,136,589
Ensembl chr19:14,119,512...14,136,613
JBrowse link
G ASXL1 ASXL transcriptional regulator 1 decreases expression ISO diethyl maleate results in decreased expression of ASXL1 mRNA CTD PMID:25270620 NCBI chr20:32,358,062...32,439,319
Ensembl chr20:32,358,330...32,439,319
JBrowse link
G ATM ATM serine/threonine kinase increases expression EXP diethyl maleate results in increased expression of ATM mRNA CTD PMID:11875189 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
JBrowse link
G ATP5F1B ATP synthase F1 subunit beta increases expression ISO diethyl maleate results in increased expression of ATP5F1B protein CTD PMID:21161181 NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984
JBrowse link
G AURKA aurora kinase A increases expression
decreases expression
ISO diethyl maleate results in increased expression of AURKA mRNA
diethyl maleate results in decreased expression of AURKA mRNA
CTD PMID:21161181 PMID:25270620 NCBI chr20:56,369,390...56,392,308
Ensembl chr20:56,369,389...56,392,337
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA CTD PMID:22564015 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2A1 BCL2 related protein A1 decreases expression ISO diethyl maleate results in decreased expression of BCL2A1 mRNA CTD PMID:21161181 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196
JBrowse link
G BCL3 BCL3 transcription coactivator decreases expression ISO diethyl maleate results in decreased expression of BCL3 mRNA CTD PMID:25270620 NCBI chr19:44,742,620...44,760,044
Ensembl chr19:44,747,705...44,760,044
JBrowse link
G BCL6B BCL6B transcription repressor decreases expression ISO diethyl maleate results in decreased expression of BCL6B mRNA CTD PMID:21161181 NCBI chr17:7,023,050...7,029,644
Ensembl chr17:7,023,050...7,030,290
JBrowse link
G BHLHE41 basic helix-loop-helix family member e41 decreases expression ISO diethyl maleate results in decreased expression of BHLHE41 mRNA CTD PMID:21161181 NCBI chr12:26,120,030...26,125,037
Ensembl chr12:26,120,030...26,125,037
JBrowse link
G BHMT betaine--homocysteine S-methyltransferase decreases expression ISO diethyl maleate results in decreased expression of BHMT mRNA CTD PMID:21161181 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288
JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 multiple interactions ISO diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA] CTD PMID:12774022 NCBI chr11:102,317,373...102,339,403
Ensembl chr11:102,317,450...102,339,403
JBrowse link
G BLVRB biliverdin reductase B increases expression ISO diethyl maleate results in increased expression of BLVRB mRNA CTD PMID:25270620 NCBI chr19:40,447,768...40,465,745
Ensembl chr19:40,447,765...40,465,764
JBrowse link
G BMF Bcl2 modifying factor decreases expression ISO diethyl maleate results in decreased expression of BMF mRNA CTD PMID:21161181 NCBI chr15:40,087,890...40,108,879
Ensembl chr15:40,087,890...40,108,892
JBrowse link
G BRIP1 BRCA1 interacting protein C-terminal helicase 1 increases expression ISO diethyl maleate results in increased expression of BRIP1 mRNA CTD PMID:21161181 NCBI chr17:61,679,139...61,864,120
Ensembl chr17:61,679,139...61,863,528
Ensembl chr17:61,679,139...61,863,528
JBrowse link
G BTBD2 BTB domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of BTBD2 mRNA CTD PMID:21161181 NCBI chr19:1,985,438...2,015,714
Ensembl chr19:1,985,438...2,034,881
JBrowse link
G BTG2 BTG anti-proliferation factor 2 increases expression
decreases expression
multiple interactions
ISO diethyl maleate results in increased expression of BTG2 mRNA
diethyl maleate results in decreased expression of BTG2 mRNA
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
CTD PMID:22003191 PMID:25270620 NCBI chr 1:203,305,519...203,309,602
Ensembl chr 1:203,305,491...203,309,602
JBrowse link
G C6 complement C6 decreases expression ISO diethyl maleate results in decreased expression of C6 mRNA CTD PMID:21161181 NCBI chr 5:41,142,116...41,261,486
Ensembl chr 5:41,142,116...41,261,438
Ensembl chr 5:41,142,116...41,261,438
JBrowse link
G CASP2 caspase 2 increases expression EXP diethyl maleate results in increased expression of CASP2 mRNA CTD PMID:11875189 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
JBrowse link
G CASP3 caspase 3 increases expression
increases cleavage
EXP diethyl maleate results in increased expression of CASP3 mRNA
diethyl maleate results in increased cleavage of CASP3 protein
CTD PMID:11875189 PMID:21105742 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 increases expression EXP diethyl maleate results in increased expression of CASP9 mRNA CTD PMID:11875189 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase decreases expression ISO diethyl maleate results in decreased expression of CAT protein CTD PMID:21161181 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CBR1 carbonyl reductase 1 increases expression ISO diethyl maleate results in increased expression of CBR1 mRNA CTD PMID:25270620 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166
JBrowse link
G CBR3 carbonyl reductase 3 increases expression
multiple interactions
EXP
ISO
diethyl maleate results in increased expression of CBR3 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA]
CTD PMID:20806931 PMID:25270620 NCBI chr21:36,134,901...36,146,562
Ensembl chr21:36,135,079...36,146,562
JBrowse link
G CCDC50 coiled-coil domain containing 50 decreases expression ISO diethyl maleate results in decreased expression of CCDC50 mRNA CTD PMID:25270620 NCBI chr 3:191,329,082...191,398,659
Ensembl chr 3:191,329,085...191,398,659
JBrowse link
G CCNA1 cyclin A1 decreases expression EXP diethyl maleate results in decreased expression of CCNA1 mRNA CTD PMID:11875189 NCBI chr13:36,430,488...36,442,870
Ensembl chr13:36,431,520...36,442,870
JBrowse link
G CCNA2 cyclin A2 increases expression ISO diethyl maleate results in increased expression of CCNA2 mRNA CTD PMID:21161181 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCND1 cyclin D1 decreases expression
increases expression
EXP
ISO
diethyl maleate results in decreased expression of CCND1 mRNA
diethyl maleate results in increased expression of CCND1 mRNA
CTD PMID:11875189 PMID:21161181 PMID:25270620 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE2 cyclin E2 increases expression ISO diethyl maleate results in increased expression of CCNE2 mRNA CTD PMID:21161181 NCBI chr 8:94,880,224...94,896,671
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CCNK cyclin K decreases expression EXP diethyl maleate results in decreased expression of CCNK mRNA CTD PMID:11875189 NCBI chr14:99,481,409...99,512,440
Ensembl chr14:99,481,169...99,535,044
JBrowse link
G CD80 CD80 molecule multiple interactions
increases expression
EXP [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
diethyl maleate results in increased expression of CD80 protein
CTD PMID:31958493 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614
JBrowse link
G CD86 CD86 molecule multiple interactions
increases expression
EXP [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein] CTD PMID:24136171 PMID:31958493 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CDC25A cell division cycle 25A increases expression ISO diethyl maleate results in increased expression of CDC25A mRNA CTD PMID:21161181 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
JBrowse link
G CDCA2 cell division cycle associated 2 increases expression ISO diethyl maleate results in increased expression of CDCA2 mRNA CTD PMID:21161181 NCBI chr 8:25,458,557...25,511,308
Ensembl chr 8:25,459,199...25,507,911
JBrowse link
G CDCA3 cell division cycle associated 3 increases expression ISO diethyl maleate results in increased expression of CDCA3 mRNA CTD PMID:21161181 NCBI chr12:6,844,795...6,852,079
Ensembl chr12:6,844,793...6,852,066
Ensembl chr12:6,844,793...6,852,066
JBrowse link
G CDCA8 cell division cycle associated 8 increases expression ISO diethyl maleate results in increased expression of CDCA8 mRNA CTD PMID:21161181 NCBI chr 1:37,692,516...37,709,719
Ensembl chr 1:37,692,481...37,709,719
JBrowse link
G CDH11 cadherin 11 decreases expression ISO diethyl maleate results in decreased expression of CDH11 mRNA CTD PMID:21161181 NCBI chr16:64,943,753...65,126,112
Ensembl chr16:64,943,753...65,126,112
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
EXP diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]
CTD PMID:11875189 PMID:27982581 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDS2 CDP-diacylglycerol synthase 2 increases expression ISO diethyl maleate results in increased expression of CDS2 mRNA CTD PMID:25270620 NCBI chr20:5,126,844...5,197,887
Ensembl chr20:5,126,879...5,197,887
JBrowse link
G CES1 carboxylesterase 1 increases reduction
decreases expression
ISO diethyl maleate results in increased reduction of CES1D protein
diethyl maleate results in decreased expression of CES1D protein
CTD PMID:19843705 PMID:21161181 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator decreases expression ISO diethyl maleate results in decreased expression of CFLAR mRNA CTD PMID:21161181 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CIDEC cell death inducing DFFA like effector c decreases expression ISO diethyl maleate results in decreased expression of CIDEC mRNA CTD PMID:21161181 NCBI chr 3:9,866,710...9,880,253
Ensembl chr 3:9,866,711...9,880,255
Ensembl chr 3:9,866,711...9,880,255
JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 decreases expression ISO diethyl maleate results in decreased expression of CITED2 mRNA CTD PMID:21161181 NCBI chr 6:139,371,807...139,374,648
Ensembl chr 6:139,371,807...139,374,648
JBrowse link
G CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 decreases expression ISO diethyl maleate results in decreased expression of CITED4 mRNA CTD PMID:21161181 NCBI chr 1:40,861,054...40,862,363
Ensembl chr 1:40,861,054...40,862,363
JBrowse link
G CKB creatine kinase B decreases reduction ISO diethyl maleate results in decreased reduction of CKB protein CTD PMID:19843705 NCBI chr14:103,519,667...103,522,833
Ensembl chr14:103,519,667...103,522,833
JBrowse link
G CMPK2 cytidine/uridine monophosphate kinase 2 decreases expression ISO diethyl maleate results in decreased expression of CMPK2 mRNA CTD PMID:21161181 NCBI chr 2:6,840,417...6,866,635
Ensembl chr 2:6,840,570...6,866,635
JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression ISO diethyl maleate results in decreased expression of COL1A1 mRNA CTD PMID:21161181 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G COL3A1 collagen type III alpha 1 chain decreases expression ISO diethyl maleate results in decreased expression of COL3A1 mRNA CTD PMID:25270620 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
JBrowse link
G COMMD3 COMM domain containing 3 increases expression ISO diethyl maleate results in increased expression of COMMD3 mRNA CTD PMID:25270620 NCBI chr10:22,316,388...22,320,306
Ensembl chr10:22,316,386...22,320,306
JBrowse link
G COMT catechol-O-methyltransferase decreases expression ISO diethyl maleate results in decreased expression of COMT mRNA CTD PMID:21161181 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G CP ceruloplasmin decreases expression ISO diethyl maleate results in decreased expression of CP mRNA CTD PMID:25270620 NCBI chr 3:149,162,410...149,222,008
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CRYM crystallin mu decreases expression ISO diethyl maleate results in decreased expression of CRYM mRNA CTD PMID:21161181 NCBI chr16:21,258,521...21,303,062
Ensembl chr16:21,238,874...21,303,083
JBrowse link
G CSRP1 cysteine and glycine rich protein 1 decreases expression ISO diethyl maleate results in decreased expression of CSRP1 mRNA CTD PMID:21161181 NCBI chr 1:201,483,530...201,507,123
Ensembl chr 1:201,483,530...201,509,456
JBrowse link
G CSRP3 cysteine and glycine rich protein 3 decreases reduction ISO diethyl maleate results in decreased reduction of CSRP3 protein CTD PMID:19843705 NCBI chr11:19,182,030...19,201,983
Ensembl chr11:19,182,030...19,210,571
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 decreases expression ISO diethyl maleate results in decreased expression of CXCL10 mRNA CTD PMID:21161181 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 decreases expression ISO diethyl maleate results in decreased expression of CXCL12 mRNA CTD PMID:21161181 NCBI chr10:44,292,088...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions
increases secretion
increases stability
EXP diethyl maleate results in increased expression of CXCL8 mRNA; diethyl maleate results in increased expression of CXCL8 protein
bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CXCL8 protein]
diethyl maleate results in increased secretion of CXCL8 protein
diethyl maleate results in increased stability of CXCL8 mRNA
CTD PMID:20491607 PMID:20541004 PMID:21920952 PMID:21969073 PMID:24136171 PMID:31958493 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 decreases expression ISO diethyl maleate results in decreased expression of CXCL9 mRNA CTD PMID:21161181 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509
JBrowse link
G CYB5A cytochrome b5 type A increases expression ISO diethyl maleate results in increased expression of CYB5A mRNA CTD PMID:25270620 NCBI chr18:74,250,846...74,291,980
Ensembl chr18:74,250,846...74,291,973
JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 decreases expression ISO diethyl maleate results in decreased expression of CYP26B1 mRNA CTD PMID:21161181 NCBI chr 2:72,129,238...72,147,862
Ensembl chr 2:72,129,238...72,148,038
JBrowse link
G DBP D-box binding PAR bZIP transcription factor decreases expression ISO diethyl maleate results in decreased expression of DBP mRNA CTD PMID:21161181 NCBI chr19:48,630,030...48,637,379
Ensembl chr19:48,630,030...48,637,379
JBrowse link
G DDIT4L DNA damage inducible transcript 4 like increases expression ISO diethyl maleate results in increased expression of DDIT4L mRNA CTD PMID:25270620 NCBI chr 4:100,185,870...100,190,468
Ensembl chr 4:100,185,870...100,190,782
JBrowse link
G DHX58 DExH-box helicase 58 decreases expression ISO diethyl maleate results in decreased expression of DHX58 mRNA CTD PMID:21161181 NCBI chr17:42,101,404...42,112,721
Ensembl chr17:42,101,404...42,112,714
JBrowse link
G DNMBP dynamin binding protein decreases expression ISO diethyl maleate results in decreased expression of DNMBP mRNA CTD PMID:21161181 NCBI chr10:99,875,571...100,009,948
Ensembl chr10:99,875,577...100,009,947
JBrowse link
G DPYSL2 dihydropyrimidinase like 2 decreases reduction ISO diethyl maleate results in decreased reduction of DPYSL2 protein CTD PMID:19843705 NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178
JBrowse link
G DTX3L deltex E3 ubiquitin ligase 3L decreases expression ISO diethyl maleate results in decreased expression of DTX3L mRNA CTD PMID:21161181 NCBI chr 3:122,564,338...122,575,203
Ensembl chr 3:122,564,338...122,575,203
JBrowse link
G DUS3L dihydrouridine synthase 3 like decreases expression ISO diethyl maleate results in decreased expression of DUS3L mRNA CTD PMID:25270620 NCBI chr19:5,785,136...5,791,210
Ensembl chr19:5,784,832...5,791,225
JBrowse link
G EEF2K eukaryotic elongation factor 2 kinase decreases expression ISO diethyl maleate results in decreased expression of EEF2K mRNA CTD PMID:21161181 NCBI chr16:22,206,278...22,288,738
Ensembl chr16:22,206,278...22,288,738
JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 decreases expression ISO diethyl maleate results in decreased expression of EIF2AK2 mRNA CTD PMID:21161181 NCBI chr 2:37,099,210...37,157,065
Ensembl chr 2:37,099,210...37,157,065
JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) increases expression ISO diethyl maleate results in increased expression of ENTPD5 mRNA CTD PMID:25270620 NCBI chr14:73,955,329...74,019,326
Ensembl chr14:73,958,010...74,019,399
JBrowse link
G ERAS ES cell expressed Ras decreases expression ISO diethyl maleate results in decreased expression of ERAS mRNA CTD PMID:25270620 NCBI chr  X:48,826,513...48,829,869
Ensembl chr  X:48,826,513...48,830,138
JBrowse link
G ERCC6L ERCC excision repair 6 like, spindle assembly checkpoint helicase increases expression ISO diethyl maleate results in increased expression of ERCC6L mRNA CTD PMID:21161181 NCBI chr  X:72,204,665...72,239,027
Ensembl chr  X:72,204,657...72,239,027
JBrowse link
G EXO1 exonuclease 1 increases expression ISO diethyl maleate results in increased expression of EXO1 mRNA CTD PMID:21161181 NCBI chr 1:241,847,967...241,889,939
Ensembl chr 1:241,847,967...241,895,148
JBrowse link
G FABP1 fatty acid binding protein 1 increases expression ISO diethyl maleate results in increased expression of FABP1 protein CTD PMID:21161181 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062
JBrowse link
G FABP7 fatty acid binding protein 7 decreases expression ISO diethyl maleate results in decreased expression of FABP7 mRNA CTD PMID:21161181 NCBI chr 6:122,749,201...122,784,074
Ensembl chr 6:122,779,716...122,784,074
JBrowse link
G FAM126B family with sequence similarity 126 member B decreases expression ISO diethyl maleate results in decreased expression of FAM126B mRNA CTD PMID:21161181 NCBI chr 2:200,973,718...201,071,671
Ensembl chr 2:200,973,718...201,071,671
JBrowse link
G FASN fatty acid synthase decreases expression ISO diethyl maleate results in decreased expression of FASN mRNA CTD PMID:21161181 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FBN1 fibrillin 1 decreases expression ISO diethyl maleate results in decreased expression of FBN1 mRNA CTD PMID:21161181 NCBI chr15:48,408,313...48,645,709
Ensembl chr15:48,408,306...48,645,849
Ensembl chr15:48,408,306...48,645,849
JBrowse link
G FBP1 fructose-bisphosphatase 1 decreases expression ISO diethyl maleate results in decreased expression of FBP1 protein CTD PMID:21161181 NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249
JBrowse link
G FGF17 fibroblast growth factor 17 decreases expression ISO diethyl maleate results in decreased expression of FGF17 mRNA CTD PMID:25270620 NCBI chr 8:22,039,708...22,048,809
Ensembl chr 8:22,042,398...22,048,809
JBrowse link
G FGG fibrinogen gamma chain decreases expression ISO diethyl maleate results in decreased expression of FGG mRNA CTD PMID:25270620 NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967
JBrowse link
G FGR FGR proto-oncogene, Src family tyrosine kinase decreases expression ISO diethyl maleate results in decreased expression of FGR mRNA CTD PMID:21161181 NCBI chr 1:27,612,064...27,635,561
Ensembl chr 1:27,612,064...27,635,185
JBrowse link
G FNDC3B fibronectin type III domain containing 3B decreases expression ISO diethyl maleate results in decreased expression of FNDC3B mRNA CTD PMID:25270620 NCBI chr 3:172,039,578...172,401,669
Ensembl chr 3:172,039,578...172,401,669
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO diethyl maleate results in increased expression of FOS mRNA CTD PMID:10915739 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO diethyl maleate results in decreased expression of G6PC mRNA CTD PMID:25270620 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases activity ISO diethyl maleate results in increased activity of G6PD protein CTD PMID:3099627 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GAB1 GRB2 associated binding protein 1 decreases expression ISO diethyl maleate results in decreased expression of GAB1 mRNA CTD PMID:25270620 NCBI chr 4:143,336,876...143,474,565
Ensembl chr 4:143,336,762...143,474,568
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase increases reduction ISO diethyl maleate results in increased reduction of GAPDH protein CTD PMID:19843705 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G GBA2 glucosylceramidase beta 2 decreases expression ISO diethyl maleate results in decreased expression of GBA2 mRNA CTD PMID:25270620 NCBI chr 9:35,736,862...35,749,228
Ensembl chr 9:35,736,866...35,749,228
JBrowse link
G GBP2 guanylate binding protein 2 decreases expression ISO diethyl maleate results in decreased expression of GBP2 mRNA CTD PMID:21161181 NCBI chr 1:89,106,132...89,126,114
Ensembl chr 1:89,106,132...89,150,456
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases activity
increases expression
ISO diethyl maleate results in increased activity of GCLC protein
diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein
CTD PMID:10915739 PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression ISO diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein CTD PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GLUL glutamate-ammonia ligase decreases expression ISO diethyl maleate results in decreased expression of GLUL mRNA CTD PMID:25270620 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,381,704...182,392,206
Ensembl chr 1:182,381,704...182,392,206
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 decreases expression ISO diethyl maleate results in decreased expression of GOT2 protein CTD PMID:21161181 NCBI chr16:58,707,131...58,734,316
Ensembl chr16:58,707,131...58,734,342
JBrowse link
G GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 decreases expression ISO diethyl maleate results in decreased expression of GPIHBP1 mRNA CTD PMID:25270620 NCBI chr 8:143,213,218...143,217,170
Ensembl chr 8:143,213,218...143,217,170
JBrowse link
G GRIA3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression ISO diethyl maleate results in decreased expression of GRIA3 mRNA CTD PMID:21161181 NCBI chr  X:123,184,278...123,490,915
Ensembl chr  X:123,184,153...123,490,915
JBrowse link
G GSN gelsolin decreases reduction ISO diethyl maleate results in decreased reduction of GSN protein CTD PMID:19843705 NCBI chr 9:121,201,483...121,332,844
Ensembl chr 9:121,207,794...121,332,843
JBrowse link
G GSR glutathione-disulfide reductase increases expression ISO diethyl maleate results in increased expression of GSR mRNA CTD PMID:25270620 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSS glutathione synthetase increases expression ISO diethyl maleate results in increased expression of GSS mRNA CTD PMID:10978506 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
JBrowse link
G GSTA2 glutathione S-transferase alpha 2 increases expression ISO diethyl maleate results in increased expression of GSTA3 protein CTD PMID:9794803 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475
JBrowse link
G GSTA3 glutathione S-transferase alpha 3 increases expression ISO diethyl maleate results in increased expression of GSTA2 mRNA CTD PMID:25270620 NCBI chr 6:52,896,646...52,909,799
Ensembl chr 6:52,896,639...52,909,698
JBrowse link
G GSTA5 glutathione S-transferase alpha 5 increases expression ISO diethyl maleate results in increased expression of GSTA5 protein CTD PMID:9794803 NCBI chr 6:52,831,742...52,846,095
Ensembl chr 6:52,831,655...52,846,095
Ensembl chr 6:52,831,655...52,846,095
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA CTD PMID:22564015 NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854
JBrowse link
G GSTM1 glutathione S-transferase mu 1 decreases expression ISO diethyl maleate results in decreased expression of GSTM1 protein CTD PMID:21161181 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTO1 glutathione S-transferase omega 1 increases expression ISO diethyl maleate results in increased expression of GSTO1 mRNA CTD PMID:25270620 NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459
JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases expression ISO diethyl maleate results in increased expression of GSTP1 protein CTD PMID:9794803 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GSTT1 glutathione S-transferase theta 1 increases expression ISO diethyl maleate results in increased expression of GSTT1 protein CTD PMID:9794803
G GTSE1 G2 and S-phase expressed 1 increases expression ISO diethyl maleate results in increased expression of GTSE1 mRNA CTD PMID:21161181 NCBI chr22:46,295,143...46,333,699
Ensembl chr22:46,296,870...46,330,810
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase increases expression ISO diethyl maleate results in increased expression of H6PD mRNA CTD PMID:25270620 NCBI chr 1:9,234,767...9,271,337
Ensembl chr 1:9,234,775...9,271,337
Ensembl chr 1:9,234,775...9,271,337
JBrowse link
G HELB DNA helicase B decreases expression ISO diethyl maleate results in decreased expression of HELB mRNA CTD PMID:25270620 NCBI chr12:66,302,493...66,343,643
Ensembl chr12:66,302,545...66,347,645
Ensembl chr12:66,302,545...66,347,645
JBrowse link
G HES6 hes family bHLH transcription factor 6 decreases expression ISO diethyl maleate results in decreased expression of HES6 mRNA CTD PMID:21161181 NCBI chr 2:238,238,267...238,240,038
Ensembl chr 2:238,238,267...238,240,662
JBrowse link
G HJURP Holliday junction recognition protein increases expression ISO diethyl maleate results in increased expression of HJURP mRNA CTD PMID:21161181 NCBI chr 2:233,836,702...233,854,535
Ensembl chr 2:233,833,416...233,854,566
JBrowse link
G HLA-E major histocompatibility complex, class I, E decreases expression ISO diethyl maleate results in decreased expression of RT1-S3 mRNA CTD PMID:21161181 NCBI chr 6:30,489,508...30,494,194
Ensembl chr 6:30,489,509...30,494,194
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP
ISO
diethyl maleate results in increased expression of HMOX1 mRNA CTD PMID:20491607 PMID:25270620 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 decreases reduction ISO diethyl maleate results in decreased reduction of HNRNPH1 protein CTD PMID:19843705 NCBI chr 5:179,614,178...179,634,784
Ensembl chr 5:179,614,178...179,634,784
JBrowse link
G HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 decreases expression ISO diethyl maleate results in decreased expression of HSD17B2 mRNA CTD PMID:21161181 NCBI chr16:82,035,253...82,098,534
Ensembl chr16:82,035,004...82,098,534
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 decreases reduction ISO diethyl maleate results in decreased reduction of HSPA5 protein CTD PMID:19843705 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 increases reduction ISO diethyl maleate results in increased reduction of HSPA8 protein CTD PMID:19843705 NCBI chr11:123,057,489...123,062,366
Ensembl chr11:123,057,489...123,063,230
JBrowse link
G HTATIP2 HIV-1 Tat interactive protein 2 increases expression ISO diethyl maleate results in increased expression of HTATIP2 mRNA CTD PMID:25270620 NCBI chr11:20,363,714...20,383,782
Ensembl chr11:20,363,685...20,383,783
Ensembl chr11:20,363,685...20,383,783
JBrowse link
G ICAM1 intercellular adhesion molecule 1 decreases expression ISO diethyl maleate results in decreased expression of ICAM1 mRNA CTD PMID:25270620 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G ID3 inhibitor of DNA binding 3, HLH protein decreases expression ISO diethyl maleate results in decreased expression of ID3 mRNA CTD PMID:25270620 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501
JBrowse link
G ID4 inhibitor of DNA binding 4, HLH protein decreases expression ISO diethyl maleate results in decreased expression of ID4 mRNA CTD PMID:25270620 NCBI chr 6:19,837,370...19,842,197
Ensembl chr 6:19,837,370...19,842,197
JBrowse link
G IFIT3 interferon induced protein with tetratricopeptide repeats 3 decreases expression ISO diethyl maleate results in decreased expression of IFIT3 mRNA CTD PMID:21161181 NCBI chr10:89,327,997...89,340,968
Ensembl chr10:89,327,997...89,340,971
JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon decreases expression ISO diethyl maleate results in decreased expression of IKBKE mRNA CTD PMID:25270620 NCBI chr 1:206,470,243...206,496,890
Ensembl chr 1:206,470,476...206,496,889
JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma increases expression ISO diethyl maleate results in increased expression of IKBKG mRNA CTD PMID:25270620 NCBI chr  X:154,541,238...154,565,046
Ensembl chr  X:154,541,199...154,565,046
JBrowse link
G IL10 interleukin 10 increases secretion EXP diethyl maleate results in increased secretion of IL10 protein CTD PMID:31958493 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL18 interleukin 18 increases expression EXP diethyl maleate results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL4 interleukin 4 multiple interactions EXP [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G INHBB inhibin subunit beta B decreases expression ISO diethyl maleate results in decreased expression of INHBB mRNA CTD PMID:25270620 NCBI chr 2:120,346,136...120,351,803
Ensembl chr 2:120,346,136...120,351,803
JBrowse link
G INMT indolethylamine N-methyltransferase decreases expression ISO diethyl maleate results in decreased expression of INMT mRNA CTD PMID:21161181 NCBI chr 7:30,752,135...30,757,602
Ensembl chr 7:30,697,985...30,757,602
JBrowse link
G INTS7 integrator complex subunit 7 decreases expression ISO diethyl maleate results in decreased expression of INTS7 mRNA CTD PMID:25270620 NCBI chr 1:211,940,328...212,035,557
Ensembl chr 1:211,940,399...212,035,557
JBrowse link
G IRF7 interferon regulatory factor 7 decreases expression ISO diethyl maleate results in decreased expression of IRF7 mRNA CTD PMID:21161181 NCBI chr11:612,555...615,999
Ensembl chr11:612,553...615,983
JBrowse link
G IRF9 interferon regulatory factor 9 decreases expression ISO diethyl maleate results in decreased expression of IRF9 mRNA CTD PMID:21161181 NCBI chr14:24,161,265...24,166,565
Ensembl chr14:24,161,265...24,166,565
JBrowse link
G IRGM immunity related GTPase M decreases expression ISO diethyl maleate results in decreased expression of IRGM mRNA CTD PMID:21161181 NCBI chr 5:150,846,521...150,902,402
Ensembl chr 5:150,846,523...150,900,736
JBrowse link
G ITGAL integrin subunit alpha L decreases expression ISO diethyl maleate results in decreased expression of ITGAL mRNA CTD PMID:21161181 NCBI chr16:30,472,683...30,523,185
Ensembl chr16:30,472,719...30,523,185
Ensembl chr16:30,472,719...30,523,185
JBrowse link
G ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 decreases expression ISO diethyl maleate results in decreased expression of ITIH3 mRNA CTD PMID:25270620 NCBI chr 3:52,794,768...52,809,009
Ensembl chr 3:52,794,768...52,809,009
JBrowse link
G ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 decreases expression ISO diethyl maleate results in decreased expression of ITIH4 mRNA CTD PMID:25270620 NCBI chr 3:52,812,962...52,830,672
Ensembl chr 3:52,812,962...52,830,688
JBrowse link
G JAM3 junctional adhesion molecule 3 decreases expression ISO diethyl maleate results in decreased expression of JAM3 mRNA CTD PMID:21161181 NCBI chr11:134,069,072...134,152,001
Ensembl chr11:134,069,071...134,152,001
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
increases phosphorylation
ISO pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
diethyl maleate results in increased expression of JUN mRNA
CTD PMID:10915739 PMID:12774022 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 decreases expression ISO diethyl maleate results in decreased expression of KCNE3 mRNA CTD PMID:25270620 NCBI chr11:74,454,841...74,467,729
Ensembl chr11:74,454,841...74,467,729
JBrowse link
G KEAP1 kelch like ECH associated protein 1 increases expression EXP diethyl maleate results in increased expression of KEAP1 protein CTD PMID:27358234 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G KIFC1 kinesin family member C1 increases expression ISO diethyl maleate results in increased expression of KIFC1 mRNA CTD PMID:21161181 NCBI chr 6:33,391,524...33,410,226
Ensembl chr 6:33,391,823...33,409,896
JBrowse link
G KLF10 Kruppel like factor 10 decreases expression ISO diethyl maleate results in decreased expression of KLF10 mRNA CTD PMID:21161181 PMID:25270620 NCBI chr 8:102,648,784...102,655,725
Ensembl chr 8:102,648,784...102,655,725
JBrowse link
G KRT75 keratin 75 increases reduction ISO diethyl maleate results in increased reduction of KRT75 protein CTD PMID:19843705 NCBI chr12:52,424,070...52,434,371
Ensembl chr12:52,424,070...52,434,371
JBrowse link
G LAMA1 laminin subunit alpha 1 decreases expression ISO diethyl maleate results in decreased expression of LAMA1 mRNA CTD PMID:25270620 NCBI chr18:6,941,742...7,117,797
Ensembl chr18:6,941,742...7,117,797
JBrowse link
G LANCL2 LanC like 2 decreases expression ISO diethyl maleate results in decreased expression of LANCL2 mRNA CTD PMID:25270620 NCBI chr 7:55,365,337...55,433,737
Ensembl chr 7:55,365,448...55,433,742
JBrowse link
G LDLR low density lipoprotein receptor decreases expression ISO diethyl maleate results in decreased expression of LDLR mRNA CTD PMID:21161181 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
G LEPR leptin receptor decreases expression ISO diethyl maleate results in decreased expression of LEPR mRNA CTD PMID:21161181 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G LGALS3BP galectin 3 binding protein decreases expression ISO diethyl maleate results in decreased expression of LGALS3BP mRNA CTD PMID:21161181 NCBI chr17:78,971,255...78,979,923
Ensembl chr17:78,971,238...78,979,947
JBrowse link
G LMNB1 lamin B1 increases expression ISO diethyl maleate results in increased expression of LMNB1 mRNA CTD PMID:21161181 NCBI chr 5:126,776,623...126,837,020
Ensembl chr 5:126,776,623...126,837,020
JBrowse link
G LMO7 LIM domain 7 decreases expression ISO diethyl maleate results in decreased expression of LMO7 mRNA CTD PMID:21161181 NCBI chr13:75,620,434...75,859,870
Ensembl chr13:75,620,434...75,859,870
JBrowse link
G LRIG3 leucine rich repeats and immunoglobulin like domains 3 decreases expression ISO diethyl maleate results in decreased expression of LRIG3 mRNA CTD PMID:21161181 NCBI chr12:58,872,155...58,920,519
Ensembl chr12:58,872,149...58,920,504
Ensembl chr12:58,872,149...58,920,504
JBrowse link
G LRRN4 leucine rich repeat neuronal 4 increases expression ISO diethyl maleate results in increased expression of LRRN4 mRNA CTD PMID:21161181 NCBI chr20:6,038,066...6,054,060
Ensembl chr20:6,040,546...6,054,060
JBrowse link
G LRTM2 leucine rich repeats and transmembrane domains 2 decreases expression ISO diethyl maleate results in decreased expression of LRTM2 mRNA CTD PMID:21161181 NCBI chr12:1,820,267...1,836,753
Ensembl chr12:1,820,267...1,836,753
JBrowse link
G LTC4S leukotriene C4 synthase decreases expression ISO diethyl maleate results in decreased expression of LTC4S mRNA CTD PMID:21161181 NCBI chr 5:179,793,986...179,796,647
Ensembl chr 5:179,793,980...179,796,647
JBrowse link
G LUM lumican decreases expression ISO diethyl maleate results in decreased expression of LUM mRNA CTD PMID:21161181 NCBI chr12:91,102,629...91,111,494
Ensembl chr12:91,102,629...91,111,494
JBrowse link
G MAFF MAF bZIP transcription factor F increases expression EXP diethyl maleate results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
JBrowse link
G MAOA monoamine oxidase A increases expression ISO diethyl maleate results in increased expression of MAOA mRNA CTD PMID:25270620 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824
JBrowse link
G MARVELD1 MARVEL domain containing 1 decreases expression ISO diethyl maleate results in decreased expression of MARVELD1 mRNA CTD PMID:21161181 NCBI chr10:97,713,730...97,718,150
Ensembl chr10:97,713,173...97,718,150
JBrowse link
G MCM10 minichromosome maintenance 10 replication initiation factor increases expression ISO diethyl maleate results in increased expression of MCM10 mRNA CTD PMID:21161181 NCBI chr10:13,161,558...13,211,110
Ensembl chr10:13,161,554...13,211,104
Ensembl chr10:13,161,554...13,211,104
JBrowse link
G MCM4 minichromosome maintenance complex component 4 increases expression ISO diethyl maleate results in increased expression of MCM4 mRNA CTD PMID:21161181 NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160
JBrowse link
G ME1 malic enzyme 1 increases expression ISO diethyl maleate results in increased expression of ME1 mRNA CTD PMID:25270620 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MFAP4 microfibril associated protein 4 decreases expression ISO diethyl maleate results in decreased expression of MFAP4 mRNA CTD PMID:21161181 NCBI chr17:19,383,445...19,387,190
Ensembl chr17:19,383,442...19,387,240
Ensembl chr17:19,383,442...19,387,240
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase decreases activity EXP diethyl maleate results in decreased activity of MGMT protein CTD PMID:16950796 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G MKI67 marker of proliferation Ki-67 increases expression ISO diethyl maleate results in increased expression of MKI67 mRNA CTD PMID:21161181 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G MKNK2 MAPK interacting serine/threonine kinase 2 decreases expression ISO diethyl maleate results in decreased expression of MKNK2 mRNA CTD PMID:21161181 NCBI chr19:2,037,471...2,051,278
Ensembl chr19:2,037,465...2,051,244
JBrowse link
G MMP12 matrix metallopeptidase 12 increases expression ISO diethyl maleate results in increased expression of MMP12 mRNA CTD PMID:10216232 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression ISO diethyl maleate results in decreased expression of MMP2 mRNA CTD PMID:21161181 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MSN moesin increases reduction ISO diethyl maleate results in increased reduction of MSN protein CTD PMID:19843705 NCBI chr  X:65,588,382...65,741,931
Ensembl chr  X:65,588,377...65,741,931
JBrowse link
G MT1A metallothionein 1A increases expression EXP diethyl maleate results in increased expression of MT1A mRNA CTD PMID:20491607 NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087
JBrowse link
G MT2A metallothionein 2A increases expression EXP diethyl maleate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
JBrowse link
G MX1 MX dynamin like GTPase 1 decreases expression ISO diethyl maleate results in decreased expression of MX1 mRNA CTD PMID:21161181 NCBI chr21:41,420,329...41,459,214
Ensembl chr21:41,420,304...41,459,214
JBrowse link
G MYBL2 MYB proto-oncogene like 2 increases expression ISO diethyl maleate results in increased expression of MYBL2 mRNA CTD PMID:21161181 NCBI chr20:43,667,114...43,716,482
Ensembl chr20:43,667,019...43,716,495
JBrowse link
G MYCN MYCN proto-oncogene, bHLH transcription factor decreases expression ISO diethyl maleate results in decreased expression of MYCN mRNA CTD PMID:25270620 NCBI chr 2:15,940,550...15,947,004
Ensembl chr 2:15,940,550...15,947,007
JBrowse link
G NAT8 N-acetyltransferase 8 (putative) decreases expression ISO diethyl maleate results in decreased expression of NAT8 mRNA CTD PMID:21161181 NCBI chr 2:73,640,723...73,642,422
Ensembl chr 2:73,640,723...73,642,422
JBrowse link
G NCAPH non-SMC condensin I complex subunit H increases expression ISO diethyl maleate results in increased expression of NCAPH mRNA CTD PMID:21161181 NCBI chr 2:96,335,766...96,377,091
Ensembl chr 2:96,335,766...96,377,091
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects localization
increases activity
increases expression
multiple interactions
decreases response to substance
ISO
EXP
diethyl maleate affects the localization of NFE2L2 protein
diethyl maleate results in increased activity of NFE2L2 protein
diethyl maleate results in increased expression of NFE2L2 protein
diethyl maleate binds to and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
NFE2L2 results in decreased susceptibility to diethyl maleate
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
CTD PMID:12235164 PMID:20806931 PMID:21465251 PMID:22003191 PMID:27358234 PMID:27982581 PMID:30114225 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA] CTD PMID:12774022 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]
Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
CTD PMID:7532384 PMID:9918918 PMID:12774022 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP
ISO
diethyl maleate results in increased expression of NQO1 mRNA CTD PMID:20491607 PMID:25270620 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 decreases expression ISO diethyl maleate results in decreased expression of NR0B2 mRNA CTD PMID:21161181 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 decreases expression ISO diethyl maleate results in decreased expression of NR1D1 mRNA CTD PMID:21161181 NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589
JBrowse link
G NREP neuronal regeneration related protein decreases expression ISO diethyl maleate results in decreased expression of NREP mRNA CTD PMID:21161181 NCBI chr 5:111,728,802...111,976,932
Ensembl chr 5:111,662,621...111,997,464
JBrowse link
G NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor decreases expression ISO diethyl maleate results in decreased expression of NSMF mRNA CTD PMID:25270620 NCBI chr 9:137,447,570...137,459,334
Ensembl chr 9:137,447,573...137,459,334
Ensembl chr 9:137,447,573...137,459,334
JBrowse link
G NTF3 neurotrophin 3 decreases expression ISO diethyl maleate results in decreased expression of NTF3 mRNA CTD PMID:21161181 NCBI chr12:5,432,108...5,495,299
Ensembl chr12:5,432,108...5,521,536
JBrowse link
G NUP153 nucleoporin 153 multiple interactions
affects localization
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; diethyl maleate results in increased phosphorylation of and results in increased O-linked glycosylation of NUP153 protein CTD PMID:20041180 NCBI chr 6:17,615,036...17,706,925
Ensembl chr 6:17,615,035...17,706,834
Ensembl chr 6:17,615,035...17,706,834
JBrowse link
G NUP88 nucleoporin 88 multiple interactions
affects localization
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]; diethyl maleate results in increased phosphorylation of and results in increased glycosylation of NUP88 protein CTD PMID:20041180 NCBI chr17:5,384,833...5,419,662
Ensembl chr17:5,360,963...5,419,676
JBrowse link
G OAF out at first homolog decreases expression ISO diethyl maleate results in decreased expression of OAF mRNA CTD PMID:21161181 NCBI chr11:120,211,032...120,230,334
Ensembl chr11:120,211,032...120,230,334
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA CTD PMID:22564015 NCBI chr 3:9,749,952...9,788,246
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G ORC1 origin recognition complex subunit 1 increases expression ISO diethyl maleate results in increased expression of ORC1 mRNA CTD PMID:21161181 NCBI chr 1:52,372,829...52,404,446
Ensembl chr 1:52,372,829...52,404,423
JBrowse link
G P2RX7 purinergic receptor P2X 7 decreases expression ISO diethyl maleate results in decreased expression of P2RX7 mRNA CTD PMID:21161181 NCBI chr12:121,132,819...121,188,032
Ensembl chr12:121,132,819...121,188,032
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP diethyl maleate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PBLD phenazine biosynthesis like protein domain containing decreases expression ISO diethyl maleate results in decreased expression of PBLD protein CTD PMID:21161181 NCBI chr10:68,282,660...68,332,958
Ensembl chr10:68,282,660...68,333,049
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP diethyl maleate results in decreased expression of PCNA mRNA CTD PMID:11875189 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PDLIM2 PDZ and LIM domain 2 decreases expression ISO diethyl maleate results in decreased expression of PDLIM2 mRNA CTD PMID:21161181 NCBI chr 8:22,578,741...22,598,026
Ensembl chr 8:22,578,279...22,598,025
JBrowse link
G PDRG1 p53 and DNA damage regulated 1 increases expression ISO diethyl maleate results in increased expression of PDRG1 mRNA CTD PMID:25270620 NCBI chr20:31,944,337...31,952,046
Ensembl chr20:31,944,337...31,952,046
JBrowse link
G PER2 period circadian regulator 2 decreases expression ISO diethyl maleate results in decreased expression of PER2 mRNA CTD PMID:21161181 NCBI chr 2:238,244,038...238,290,102
Ensembl chr 2:238,244,044...238,290,102
JBrowse link
G PER3 period circadian regulator 3 decreases expression ISO diethyl maleate results in decreased expression of PER3 mRNA CTD PMID:21161181 NCBI chr 1:7,784,285...7,845,181
Ensembl chr 1:7,784,320...7,845,177
JBrowse link
G PGD phosphogluconate dehydrogenase increases activity ISO diethyl maleate results in increased activity of PGD protein CTD PMID:3099627 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PGRMC1 progesterone receptor membrane component 1 increases expression ISO diethyl maleate results in increased expression of PGRMC1 mRNA CTD PMID:25270620 NCBI chr  X:119,236,285...119,244,466
Ensembl chr  X:119,236,245...119,244,466
JBrowse link
G PIR pirin increases expression ISO diethyl maleate results in increased expression of PIR mRNA CTD PMID:25270620 NCBI chr  X:15,384,799...15,493,333
Ensembl chr  X:15,384,799...15,493,564
JBrowse link
G PKLR pyruvate kinase L/R decreases expression ISO diethyl maleate results in decreased expression of PKLR mRNA CTD PMID:21161181 NCBI chr 1:155,289,293...155,301,438
Ensembl chr 1:155,289,293...155,301,438
JBrowse link
G PLAT plasminogen activator, tissue type increases expression
decreases expression
ISO diethyl maleate results in increased expression of PLAT mRNA
diethyl maleate results in decreased expression of PLAT mRNA
CTD PMID:21161181 PMID:25270620 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,676
Ensembl chr 8:42,174,718...42,207,676
JBrowse link
G PLEK pleckstrin decreases expression ISO diethyl maleate results in decreased expression of PLEK mRNA CTD PMID:21161181 NCBI chr 2:68,365,282...68,397,453
Ensembl chr 2:68,365,282...68,397,453
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
decreases activity
ISO diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol inhibits the reaction [diethyl maleate results in decreased activity of PPARA protein]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate results in decreased activity of PPARA protein] CTD PMID:17134953 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARGC1B PPARG coactivator 1 beta decreases expression ISO diethyl maleate results in decreased expression of PPARGC1B mRNA CTD PMID:21161181 NCBI chr 5:149,730,302...149,857,861
Ensembl chr 5:149,730,298...149,855,022
JBrowse link
G PPP1R3B protein phosphatase 1 regulatory subunit 3B decreases expression ISO diethyl maleate results in decreased expression of PPP1R3B mRNA CTD PMID:21161181 NCBI chr 8:9,136,255...9,151,586
Ensembl chr 8:9,136,255...9,151,574
JBrowse link
G PPP1R3C protein phosphatase 1 regulatory subunit 3C decreases expression ISO diethyl maleate results in decreased expression of PPP1R3C mRNA CTD PMID:21161181 NCBI chr10:91,628,442...91,633,071
Ensembl chr10:91,628,442...91,633,071
JBrowse link
G PRDM14 PR/SET domain 14 decreases expression ISO diethyl maleate results in decreased expression of PRDM14 mRNA CTD PMID:25270620 NCBI chr 8:70,051,613...70,071,252
Ensembl chr 8:70,051,651...70,071,693
JBrowse link
G PRDX1 peroxiredoxin 1 increases expression ISO
EXP
diethyl maleate results in increased expression of PRDX1 mRNA CTD PMID:9506838 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,511,036...45,523,047
Ensembl chr 1:45,511,036...45,523,047
JBrowse link
G PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 decreases expression ISO diethyl maleate results in decreased expression of PRKAB1 mRNA CTD PMID:25270620 NCBI chr12:119,667,864...119,681,624
Ensembl chr12:119,667,864...119,681,624
JBrowse link
G PRKCB protein kinase C beta affects expression EXP diethyl maleate affects the expression of PRKCB protein CTD PMID:31958493 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
JBrowse link
G PRKCD protein kinase C delta multiple interactions ISO Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCD protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCD protein CTD PMID:11118818 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717
JBrowse link
G PRKCE protein kinase C epsilon multiple interactions ISO Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCE protein CTD PMID:11118818 NCBI chr 2:45,651,315...46,187,990
Ensembl chr 2:45,651,345...46,187,990
JBrowse link
G PRSS8 serine protease 8 decreases expression ISO diethyl maleate results in decreased expression of PRSS8 mRNA CTD PMID:21161181 NCBI chr16:31,131,433...31,135,727
Ensembl chr16:31,131,433...31,135,727
JBrowse link
G PTGR1 prostaglandin reductase 1 increases expression ISO diethyl maleate results in increased expression of PTGR1 mRNA CTD PMID:25270620 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G PTPN14 protein tyrosine phosphatase non-receptor type 14 increases expression ISO diethyl maleate results in increased expression of PTPN14 mRNA CTD PMID:25270620 NCBI chr 1:214,348,700...214,551,677
Ensembl chr 1:214,348,700...214,552,449
JBrowse link
G PUS1 pseudouridine synthase 1 decreases expression ISO diethyl maleate results in decreased expression of PUS1 mRNA CTD PMID:25270620 NCBI chr12:131,929,268...131,945,896
Ensembl chr12:131,929,200...131,945,896
JBrowse link
G RAB27A RAB27A, member RAS oncogene family decreases expression ISO diethyl maleate results in decreased expression of RAB27A mRNA CTD PMID:21161181 NCBI chr15:55,202,966...55,291,338
Ensembl chr15:55,202,966...55,319,113
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] CTD PMID:20116392 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RNF114 ring finger protein 114 decreases expression ISO diethyl maleate results in decreased expression of RNF114 mRNA CTD PMID:25270620 NCBI chr20:49,936,397...49,953,885
Ensembl chr20:49,936,336...49,953,885
JBrowse link
G RNF14 ring finger protein 14 increases expression ISO diethyl maleate results in increased expression of RNF14 mRNA CTD PMID:25270620 NCBI chr 5:141,966,807...141,990,292
Ensembl chr 5:141,958,328...141,990,292
JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 increases expression ISO diethyl maleate results in increased expression of RRM2 mRNA CTD PMID:21161181 NCBI chr 2:10,122,568...10,211,010
Ensembl chr 2:10,120,698...10,211,725
JBrowse link
G RSAD2 radical S-adenosyl methionine domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of RSAD2 mRNA CTD PMID:21161181 NCBI chr 2:6,865,733...6,898,239
Ensembl chr 2:6,865,806...6,898,239
JBrowse link
G S100A9 S100 calcium binding protein A9 decreases expression ISO diethyl maleate results in decreased expression of S100A9 mRNA CTD PMID:21161181 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023
JBrowse link
G SASH3 SAM and SH3 domain containing 3 decreases expression ISO diethyl maleate results in decreased expression of SASH3 mRNA CTD PMID:21161181 NCBI chr  X:129,779,949...129,795,201
Ensembl chr  X:129,779,949...129,795,201
JBrowse link
G SCD stearoyl-CoA desaturase decreases expression ISO diethyl maleate results in decreased expression of SCD1 mRNA CTD PMID:21161181 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SDS serine dehydratase decreases expression ISO diethyl maleate results in decreased expression of SDS mRNA CTD PMID:21161181 NCBI chr12:113,392,445...113,403,887
Ensembl chr12:113,392,445...113,426,301
JBrowse link
G SERPIND1 serpin family D member 1 decreases expression ISO diethyl maleate results in decreased expression of SERPIND1 mRNA CTD PMID:25270620 NCBI chr22:20,774,113...20,787,720
Ensembl chr22:20,774,113...20,787,720
JBrowse link
G SEZ6 seizure related 6 homolog decreases expression ISO diethyl maleate results in decreased expression of SEZ6 mRNA CTD PMID:21161181 NCBI chr17:28,954,905...29,006,440
Ensembl chr17:28,954,901...29,006,440
JBrowse link
G SFXN1 sideroflexin 1 decreases expression ISO diethyl maleate results in decreased expression of SFXN1 mRNA CTD PMID:25270620 NCBI chr 5:175,478,560...175,529,742
Ensembl chr 5:175,477,062...175,529,742
JBrowse link
G SIX4 SIX homeobox 4 increases expression ISO diethyl maleate results in increased expression of SIX4 mRNA CTD PMID:25270620 NCBI chr14:60,709,539...60,724,351
Ensembl chr14:60,709,539...60,724,351
JBrowse link
G SLC16A6 solute carrier family 16 member 6 decreases expression ISO diethyl maleate results in decreased expression of SLC16A6 mRNA CTD PMID:25270620 NCBI chr17:68,267,026...68,291,439
Ensembl chr17:68,267,026...68,291,267
JBrowse link
G SLC1A4 solute carrier family 1 member 4 increases expression ISO diethyl maleate results in increased expression of SLC1A4 mRNA CTD PMID:25270620 NCBI chr 2:64,988,479...65,023,865
Ensembl chr 2:64,988,477...65,023,865
JBrowse link
G SLC2A2 solute carrier family 2 member 2 decreases expression ISO diethyl maleate results in decreased expression of SLC2A2 mRNA CTD PMID:21161181 NCBI chr 3:170,996,341...171,026,721
Ensembl chr 3:170,996,347...171,026,743
JBrowse link
G SLC2A5 solute carrier family 2 member 5 decreases expression ISO diethyl maleate results in decreased expression of SLC2A5 mRNA CTD PMID:21161181 NCBI chr 1:9,035,106...9,072,259
Ensembl chr 1:9,035,106...9,088,478
JBrowse link
G SLC39A14 solute carrier family 39 member 14 decreases expression ISO diethyl maleate results in decreased expression of SLC39A14 mRNA CTD PMID:25270620 NCBI chr 8:22,367,278...22,434,129
Ensembl chr 8:22,367,249...22,434,129
Ensembl chr 8:22,367,249...22,434,129
JBrowse link
G SLC40A1 solute carrier family 40 member 1 multiple interactions EXP diethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA] CTD PMID:21303654 NCBI chr 2:189,560,590...189,580,811
Ensembl chr 2:189,560,579...189,583,758
Ensembl chr 2:189,560,579...189,583,758
JBrowse link
G SLC44A4 solute carrier family 44 member 4 decreases expression ISO diethyl maleate results in decreased expression of SLC44A4 mRNA CTD PMID:21161181 NCBI chr 6:31,863,192...31,878,997
Ensembl chr 6:31,863,192...31,879,046
JBrowse link
G SLC7A11 solute carrier family 7 member 11 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA] CTD PMID:12235164 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SLC9A3R1 SLC9A3 regulator 1 decreases expression ISO diethyl maleate results in decreased expression of SLC9A3R1 mRNA CTD PMID:21161181 NCBI chr17:74,748,628...74,769,353
Ensembl chr17:74,748,628...74,769,353
JBrowse link
G SLCO2A1 solute carrier organic anion transporter family member 2A1 decreases expression ISO diethyl maleate results in decreased expression of SLCO2A1 mRNA CTD PMID:21161181 NCBI chr 3:133,932,701...134,029,955
Ensembl chr 3:133,932,701...134,052,184
Ensembl chr 3:133,932,701...134,052,184
JBrowse link
G SMC4 structural maintenance of chromosomes 4 increases expression ISO diethyl maleate results in increased expression of SMC4 mRNA CTD PMID:21161181 NCBI chr 3:160,399,638...160,434,953
Ensembl chr 3:160,399,274...160,434,954
JBrowse link
G SMTN smoothelin increases expression ISO diethyl maleate results in increased expression of SMTN mRNA CTD PMID:21161181 NCBI chr22:31,064,118...31,104,624
Ensembl chr22:31,064,105...31,104,757
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 decreases expression ISO diethyl maleate results in decreased expression of SOCS3 mRNA CTD PMID:25270620 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SORL1 sortilin related receptor 1 decreases expression ISO diethyl maleate results in decreased expression of SORL1 mRNA CTD PMID:21161181 NCBI chr11:121,452,314...121,633,763
Ensembl chr11:121,452,314...121,633,763
JBrowse link
G SOX9 SRY-box transcription factor 9 increases expression ISO diethyl maleate results in increased expression of SOX9 mRNA CTD PMID:21161181 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
JBrowse link
G SP5 Sp5 transcription factor decreases expression ISO diethyl maleate results in decreased expression of SP5 mRNA CTD PMID:25270620 NCBI chr 2:170,714,725...170,718,078
Ensembl chr 2:170,715,337...170,718,078
JBrowse link
G SPC25 SPC25 component of NDC80 kinetochore complex increases expression ISO diethyl maleate results in increased expression of SPC25 mRNA CTD PMID:21161181 NCBI chr 2:168,865,045...168,890,443
Ensembl chr 2:168,834,132...168,913,371
JBrowse link
G SPTA1 spectrin alpha, erythrocytic 1 increases expression ISO diethyl maleate results in increased expression of SPTA1 mRNA CTD PMID:25270620 NCBI chr 1:158,610,498...158,686,715
Ensembl chr 1:158,610,704...158,686,715
JBrowse link
G SPTAN1 spectrin alpha, non-erythrocytic 1 increases cleavage EXP diethyl maleate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 9:128,552,564...128,633,662
Ensembl chr 9:128,552,558...128,633,662
JBrowse link
G SPTBN4 spectrin beta, non-erythrocytic 4 increases expression ISO diethyl maleate results in increased expression of SPTBN4 mRNA CTD PMID:25270620 NCBI chr19:40,467,001...40,576,464
Ensembl chr19:40,466,241...40,576,464
JBrowse link
G SQSTM1 sequestosome 1 increases expression ISO diethyl maleate results in increased expression of SQSTM1 mRNA CTD PMID:25270620 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 decreases expression ISO diethyl maleate results in decreased expression of SREBF1 mRNA CTD PMID:21161181 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G SRXN1 sulfiredoxin 1 multiple interactions
increases expression
ISO
EXP
[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
diethyl maleate results in increased expression of SRXN1 protein
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
diethyl maleate results in increased expression of SRXN1 mRNA; diethyl maleate results in increased expression of SRXN1 protein
CTD PMID:22003191 PMID:25270620 PMID:27358234 PMID:27982581 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,370
Ensembl chr20:646,615...653,370
JBrowse link
G STAT1 signal transducer and activator of transcription 1 decreases expression ISO diethyl maleate results in decreased expression of STAT1 mRNA CTD PMID:21161181 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STEAP4 STEAP4 metalloreductase decreases expression ISO diethyl maleate results in decreased expression of STEAP4 mRNA CTD PMID:25270620 NCBI chr 7:88,270,892...88,306,894
Ensembl chr 7:88,270,892...88,306,891
Ensembl chr 7:88,270,892...88,306,891
JBrowse link
G SULF2 sulfatase 2 decreases expression ISO diethyl maleate results in decreased expression of SULF2 mRNA CTD PMID:21161181 NCBI chr20:47,657,406...47,786,627
Ensembl chr20:47,656,348...47,786,616
JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 decreases expression ISO diethyl maleate results in decreased expression of SULT1A1 protein CTD PMID:21161181 NCBI chr16:28,605,587...28,623,395
Ensembl chr16:28,605,196...28,623,625
Ensembl chr16:28,605,196...28,623,625
JBrowse link
G TAGLN transgelin decreases expression ISO diethyl maleate results in decreased expression of TAGLN mRNA CTD PMID:21161181 NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464
JBrowse link
G TBCEL tubulin folding cofactor E like increases expression ISO diethyl maleate results in increased expression of TBCEL mRNA CTD PMID:25270620 NCBI chr11:121,024,102...121,090,776
Ensembl chr11:121,024,072...121,090,775
JBrowse link
G TENT5A terminal nucleotidyltransferase 5A decreases expression ISO diethyl maleate results in decreased expression of TENT5A mRNA CTD PMID:21161181 NCBI chr 6:81,745,730...81,752,681
Ensembl chr 6:81,491,439...81,752,774
JBrowse link
G TESMIN testis expressed metallothionein like protein affects localization ISO diethyl maleate affects the localization of TESMIN protein CTD PMID:12606435 NCBI chr11:68,706,674...68,751,564
Ensembl chr11:68,707,440...68,751,520
JBrowse link
G TF transferrin decreases expression ISO diethyl maleate results in decreased expression of TF protein CTD PMID:21161181 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641
JBrowse link
G TFEB transcription factor EB decreases expression ISO diethyl maleate results in decreased expression of TFEB mRNA CTD PMID:25270620 NCBI chr 6:41,683,978...41,736,223
Ensembl chr 6:41,683,978...41,736,259
JBrowse link
G TGM2 transglutaminase 2 increases expression ISO diethyl maleate results in increased expression of TGM2 mRNA CTD PMID:21161181 NCBI chr20:38,127,385...38,166,508
Ensembl chr20:38,127,385...38,166,578
JBrowse link
G THBS1 thrombospondin 1 increases expression ISO diethyl maleate results in increased expression of THBS1 mRNA CTD PMID:21161181 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
G THRSP thyroid hormone responsive decreases expression ISO diethyl maleate results in decreased expression of THRSP mRNA CTD PMID:21161181 NCBI chr11:78,063,861...78,068,351
Ensembl chr11:78,063,861...78,068,351
JBrowse link
G TM4SF1 transmembrane 4 L six family member 1 increases expression ISO diethyl maleate results in increased expression of TM4SF1 mRNA CTD PMID:21161181 NCBI chr 3:149,369,022...149,377,781
Ensembl chr 3:149,369,022...149,377,692
JBrowse link
G TMEM209 transmembrane protein 209 increases expression ISO diethyl maleate results in increased expression of TMEM209 mRNA CTD PMID:25270620 NCBI chr 7:130,164,713...130,205,406
Ensembl chr 7:130,164,713...130,207,770
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP
ISO
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
CTD PMID:7476933 PMID:7532384 PMID:12774022 PMID:20116392 PMID:31958493 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF14 TNF receptor superfamily member 14 decreases expression ISO diethyl maleate results in decreased expression of TNFRSF14 mRNA CTD PMID:21161181 NCBI chr 1:2,556,371...2,563,829
Ensembl chr 1:2,555,639...2,565,382
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO
EXP
TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD PMID:22003191 PMID:27982581 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TPM2 tropomyosin 2 decreases expression ISO diethyl maleate results in decreased expression of TPM2 mRNA CTD PMID:21161181 NCBI chr 9:35,681,993...35,690,056
Ensembl chr 9:35,681,992...35,690,056
JBrowse link
G TRAP1 TNF receptor associated protein 1 multiple interactions
decreases response to substance
EXP diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein]
TRAP1 protein results in decreased susceptibility to diethyl maleate
CTD PMID:17853063 NCBI chr16:3,658,037...3,717,524
Ensembl chr16:3,651,639...3,717,553
JBrowse link
G TRDMT1 tRNA aspartic acid methyltransferase 1 decreases expression ISO diethyl maleate results in decreased expression of TRDMT1 mRNA CTD PMID:25270620 NCBI chr10:17,137,336...17,202,066
Ensembl chr10:17,137,336...17,202,054
JBrowse link
G TRIM6 tripartite motif containing 6 decreases expression ISO diethyl maleate results in decreased expression of TRIM6 mRNA CTD PMID:21161181 NCBI chr11:5,596,111...5,612,952
Ensembl chr11:5,596,109...5,612,958
JBrowse link
G TRIP13 thyroid hormone receptor interactor 13 increases expression ISO diethyl maleate results in increased expression of TRIP13 mRNA CTD PMID:21161181 NCBI chr 5:892,884...919,348
Ensembl chr 5:892,884...919,357
JBrowse link
G TSC22D1 TSC22 domain family member 1 decreases expression ISO diethyl maleate results in decreased expression of TSC22D1 mRNA CTD PMID:21161181 NCBI chr13:44,432,143...44,576,825
Ensembl chr13:44,432,143...44,577,147
JBrowse link
G TSPAN8 tetraspanin 8 decreases expression ISO diethyl maleate results in decreased expression of TSPAN8 mRNA CTD PMID:21161181 NCBI chr12:71,125,093...71,157,999
Ensembl chr12:71,125,085...71,441,898
JBrowse link
G TSTD1 thiosulfate sulfurtransferase like domain containing 1 decreases expression ISO diethyl maleate results in decreased expression of TSTD1 mRNA CTD PMID:25270620 NCBI chr 1:161,037,631...161,038,964
Ensembl chr 1:161,037,631...161,038,977
JBrowse link
G TXN thioredoxin decreases activity EXP diethyl maleate results in decreased activity of TXN protein CTD PMID:15388247 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TXNIP thioredoxin interacting protein increases expression ISO diethyl maleate results in increased expression of TXNIP mRNA CTD PMID:21161181 NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP diethyl maleate results in increased expression of TXNRD1 mRNA CTD PMID:15521073 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UBD ubiquitin D decreases expression ISO diethyl maleate results in decreased expression of UBD mRNA CTD PMID:21161181 NCBI chr 6:29,555,515...29,559,732
Ensembl chr 6:29,555,515...29,559,732
JBrowse link
G UHRF1 ubiquitin like with PHD and ring finger domains 1 increases expression ISO diethyl maleate results in increased expression of UHRF1 mRNA CTD PMID:21161181 NCBI chr19:4,903,080...4,962,154
Ensembl chr19:4,903,080...4,962,154
JBrowse link
G USP18 ubiquitin specific peptidase 18 decreases expression ISO diethyl maleate results in decreased expression of USP18 mRNA CTD PMID:21161181 NCBI chr22:18,149,855...18,177,397
Ensembl chr22:18,150,170...18,177,397
JBrowse link
G USP2 ubiquitin specific peptidase 2 decreases expression ISO diethyl maleate results in decreased expression of USP2 mRNA CTD PMID:21161181 NCBI chr11:119,355,215...119,381,690
Ensembl chr11:119,355,215...119,381,711
JBrowse link
G WDR31 WD repeat domain 31 decreases expression ISO diethyl maleate results in decreased expression of WDR31 mRNA CTD PMID:25270620 NCBI chr 9:113,313,222...113,340,326
Ensembl chr 9:113,313,222...113,340,298
JBrowse link
G WDR6 WD repeat domain 6 decreases expression ISO diethyl maleate results in decreased expression of WDR6 mRNA CTD PMID:21161181 NCBI chr 3:49,007,391...49,015,951
Ensembl chr 3:49,007,062...49,015,953
JBrowse link
G YPEL5 yippee like 5 increases expression ISO diethyl maleate results in increased expression of YPEL5 mRNA CTD PMID:25270620 NCBI chr 2:30,146,568...30,160,533
Ensembl chr 2:30,146,941...30,160,533
JBrowse link
G ZFP36 ZFP36 ring finger protein increases expression EXP diethyl maleate results in increased expression of ZFP36 protein CTD PMID:21969073 NCBI chr19:39,406,847...39,409,407
Ensembl chr19:39,406,847...39,409,412
JBrowse link
G ZFP37 ZFP37 zinc finger protein decreases expression ISO diethyl maleate results in decreased expression of ZFP37 mRNA CTD PMID:21161181 NCBI chr 9:113,038,377...113,056,724
Ensembl chr 9:113,038,377...113,056,759
Ensembl chr 9:113,038,377...113,056,759
JBrowse link
G ZNF367 zinc finger protein 367 increases expression ISO diethyl maleate results in increased expression of ZNF367 mRNA CTD PMID:21161181 NCBI chr 9:96,385,941...96,418,639
Ensembl chr 9:96,385,941...96,418,370
JBrowse link
G ZNF716 zinc finger protein 716 decreases reduction ISO diethyl maleate results in decreased reduction of ZFP493 protein CTD PMID:19843705 NCBI chr 7:57,450,177...57,473,559
Ensembl chr 7:57,450,177...57,473,559
JBrowse link
G ZNRD2 zinc ribbon domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of ZNRD2 mRNA CTD PMID:25270620 NCBI chr11:65,570,477...65,571,888
Ensembl chr11:65,570,460...65,573,942
JBrowse link
dimethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:30703375 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ATP6V0D2 ATPase H+ transporting V0 subunit d2 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA] CTD PMID:30742845 NCBI chr 8:86,098,910...86,154,225
Ensembl chr 8:85,987,323...86,154,225
JBrowse link
G BACH1 BTB domain and CNC homolog 1 affects localization EXP Dimethyl Fumarate affects the localization of BACH1 protein CTD PMID:27277809 NCBI chr21:29,298,922...29,361,894
Ensembl chr21:29,194,071...29,630,751
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP
ISO
Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCL2 mRNA]
Dimethyl Fumarate results in decreased expression of CCL2 mRNA
CTD PMID:26683377 PMID:27277809 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CD68 CD68 molecule multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA] CTD PMID:27277809 NCBI chr17:7,579,638...7,582,111
Ensembl chr17:7,579,491...7,582,111
JBrowse link
G CSF1R colony stimulating factor 1 receptor multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372
JBrowse link
G CTSK cathepsin K multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,796,208...150,808,260
Ensembl chr 1:150,796,208...150,808,260
JBrowse link
G FTH1 ferritin heavy chain 1 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]
Dimethyl Fumarate results in increased expression of FTH1 mRNA; Dimethyl Fumarate results in increased expression of FTH1 protein
CTD PMID:28289076 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G FTL ferritin light chain increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of FTL mRNA; Dimethyl Fumarate results in increased expression of FTL protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]
CTD PMID:28289076 NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of GCLC protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]
CTD PMID:27277809 PMID:30248482 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]
Dimethyl Fumarate results in increased expression of GCLM protein
CTD PMID:27277809 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GPX4 glutathione peroxidase 4 increases metabolic processing EXP Dimethyl Fumarate results in increased metabolism of GPX4 protein CTD PMID:29917289 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,926...1,106,791
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]
Dimethyl Fumarate results in increased expression of GSR protein
CTD PMID:27277809 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
Dimethyl Fumarate results in increased expression of HMOX1 mRNA; Dimethyl Fumarate results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
[Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
CTD PMID:20961405 PMID:23942037 PMID:26683377 PMID:27277809 PMID:28790194 PMID:29950142 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
Dimethyl Fumarate results in decreased expression of ICAM1 mRNA
CTD PMID:26683377 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IFNG interferon gamma multiple interactions EXP
ISO
Dimethyl Fumarate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]
Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]
CTD PMID:15663561 PMID:23942037 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA] CTD PMID:26683377 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,653
Ensembl chr 8:42,271,302...42,332,653
JBrowse link
G IL6R interleukin 6 receptor decreases expression EXP Dimethyl Fumarate results in decreased expression of IL6R protein CTD PMID:28134847 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450
JBrowse link
G LAMP2 lysosomal associated membrane protein 2 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of LAMP2 protein alternative form] CTD PMID:29950142 NCBI chr  X:120,426,148...120,469,349
Ensembl chr  X:120,426,148...120,469,365
Ensembl chr  X:120,426,148...120,469,365
JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA] CTD PMID:27277809 NCBI chr MT:9,207...9,990
Ensembl chr MT:9,207...9,990
JBrowse link
G MT-CYB mitochondrially encoded cytochrome b increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of CYTB mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of CYTB mRNA]
CTD PMID:27277809 NCBI chr MT:14,747...15,887
Ensembl chr MT:14,747...15,887