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ONTOLOGY REPORT - ANNOTATIONS


Term:polyketomycin
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Accession:CHEBI:66771 term browser browse the term
Definition:A carbohydrate-containing antibiotic isolated from the culture broth of Streptomyces sp.MK277-AF1. It exhibits potent antibacterial activity against several Gram-positive bacterial strains and is also found to be cytotoxic against a number of tumour cell lines.
Synonyms:exact_synonym: (2R,3S,6S)-2-methyl-6-{[(1S,3E,4aS,12aR)-4a,6,12a-trihydroxy-3-(1-hydroxyethylidene)-9-methoxy-11-methyl-2,4,5,7,10-pentaoxo-1,2,3,4,4a,5,7,10,12,12a-decahydrotetracen-1-yl]oxy}tetrahydro-2H-pyran-3-yl 2,6-dideoxy-4-O-(2-hydroxy-3,6-dimethylbenzoyl)-3-C-methyl-alpha-L-xylo-hexopyranoside
 related_synonym: Formula=C44H48O18;   InChI=1S/C44H48O18/c1-16-9-10-17(2)33(47)28(16)41(53)62-39-21(6)59-27(15-42(39,7)54)60-24-11-12-26(58-20(24)5)61-40-36(50)30(19(4)45)37(51)44(56)38(52)31-22(14-43(40,44)55)18(3)29-32(35(31)49)23(46)13-25(57-8)34(29)48/h9-10,13,20-21,24,26-27,39-40,45,47,49,54-56H,11-12,14-15H2,1-8H3/b30-19+/t20-,21+,24+,26+,27+,39-,40-,42-,43-,44-/m1/s1;   InChIKey=OWRCRVABZYJUES-FLJLGRLJSA-N;   SMILES=[H][C@@]1(CC[C@]([H])(O[C@H]2C[C@@](C)(O)[C@H](OC(=O)c3c(C)ccc(C)c3O)[C@H](C)O2)[C@@H](C)O1)O[C@@H]1C(=O)\\C(=C(\\C)O)C(=O)[C@@]2(O)C(=O)c3c(O)c4C(=O)C=C(OC)C(=O)c4c(C)c3C[C@@]12O
 xref: CAS:200625-47-4;   PMID:10344562;   PMID:19266534;   PMID:9531983;   PMID:9531984;   Reaxys:8184047


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Path 1
Term Annotations click to browse term
  CHEBI ontology 19778
    role 19725
      biological role 19724
        antimicrobial agent 17271
          carbohydrate-containing antibiotic 2557
            polyketomycin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19778
    subatomic particle 19776
      composite particle 19776
        hadron 19776
          baryon 19776
            nucleon 19776
              atomic nucleus 19776
                atom 19776
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19556
                        carbon atom 19545
                          organic molecular entity 19545
                            organic group 18459
                              organic divalent group 18453
                                organodiyl group 18453
                                  carbonyl group 18354
                                    carbonyl compound 18354
                                      carboxylic acid 18027
                                        aromatic carboxylic acid 10882
                                          benzoic acids 10852
                                            benzoic acid 3814
                                              hydroxybenzoic acid 3206
                                                monohydroxybenzoic acid 1262
                                                  salicylic acid 743
                                                    3,6-dimethylsalicylic acid 0
                                                      polyketomycin 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.