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Term:phakellistatin 14
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Accession:CHEBI:66742 term browser browse the term
Definition:A homodetic cyclic peptide isolated from a marine sponge Phakellia sp. It exhibits cytotoxic activity against murine P388 lymphocytic leukemia cells and moderate cancer cell growth inhibitory activity against a panel of human cancer cells.
Synonyms:exact_synonym: methyl {(3S,6S,9S,12S,15S,18S,23aS)-3-benzyl-18-[(2S)-butan-2-yl]-9,15-dimethyl-12-[2-(methylsulfinyl)ethyl]-1,4,7,10,13,16,19-heptaoxodocosahydro-1H-pyrrolo[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosin-6-yl}acetate
 related_synonym: Formula=C36H53N7O10S;   InChI=1S/C36H53N7O10S/c1-7-20(2)29-36(51)43-16-11-14-27(43)35(50)41-25(18-23-12-9-8-10-13-23)34(49)40-26(19-28(44)53-5)33(48)38-21(3)30(45)39-24(15-17-54(6)52)32(47)37-22(4)31(46)42-29/h8-10,12-13,20-22,24-27,29H,7,11,14-19H2,1-6H3,(H,37,47)(H,38,48)(H,39,45)(H,40,49)(H,41,50)(H,42,46)/t20-,21-,22-,24-,25-,26-,27-,29-,54?/m0/s1;   InChIKey=ZBIJFJOAXJXGTR-KLZQDHKKSA-N;   SMILES=CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCS(C)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)OC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O
 xref: Chemspider:10480460;   PMID:15679318 "Europe PMC";   Reaxys:10232750 "Reaxys"

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  CHEBI ontology 223
    role 223
      biological role 223
        biochemical role 185
          metabolite 177
            phakellistatin 14 0
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  CHEBI ontology 223
    subatomic particle 223
      composite particle 223
        hadron 223
          baryon 223
            nucleon 223
              atomic nucleus 223
                atom 223
                  main group element atom 216
                    p-block element atom 216
                      carbon group element atom 205
                        carbon atom 204
                          organic molecular entity 204
                            organic group 153
                              organic divalent group 152
                                organodiyl group 152
                                  carbonyl group 152
                                    carbonyl compound 152
                                      carboxylic acid 112
                                        carboacyl group 47
                                          univalent carboacyl group 47
                                            carbamoyl group 44
                                              carboxamide 44
                                                peptide 19
                                                  cyclic peptide 3
                                                    homodetic cyclic peptide 1
                                                      phakellistatin 14 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.