CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Panduratin A
Accession: CHEBI:66725
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Definition: A diarylheptanoid that has formula C26H30O4.
Synonyms: related_synonym: (2,6-dihydroxy-4-methoxyphenyl)[(1R,2S,6R)-3-methyl-2-(3-methylbut-2-en-1-yl)-6-phenylcyclohex-3-en-1-yl]methanone; Formula=C26H30O4; InChI=1S/C26H30O4/c1-16(2)10-12-20-17(3)11-13-21(18-8-6-5-7-9-18)24(20)26(29)25-22(27)14-19(30-4)15-23(25)28/h5-11,14-15,20-21,24,27-28H,12-13H2,1-4H3/t20-,21+,24-/m1/s1; InChIKey=LYDZCXVWCFJAKQ-ZFGGDYGUSA-N; SMILES=COc1cc(O)c(C(=O)[C@@H]2[C@H](CC=C(C)C)C(C)=CC[C@H]2c2ccccc2)c(O)c1
xref_mesh: MESH:C482884
xref: PMID:15930750
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Acin1
apoptotic chromatin condensation inducer 1
increases degradation
ISO
panduratin A results in increased degradation of ACIN1 protein
CTD
PMID:16497706
NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
panduratin A results in increased expression of BAX protein
CTD
PMID:16497706
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
panduratin A results in decreased expression of BCL2 protein
CTD
PMID:16497706
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bid
BH3 interacting domain death agonist
decreases expression
ISO
panduratin A results in decreased expression of BID protein
CTD
PMID:16497706
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Casp3
caspase 3
increases cleavage
ISO
panduratin A results in increased cleavage of CASP3 protein
CTD
PMID:16497706
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp6
caspase 6
increases cleavage
ISO
panduratin A results in increased cleavage of CASP6 protein
CTD
PMID:16497706
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp8
caspase 8
increases cleavage
ISO
panduratin A results in increased cleavage of CASP8 protein
CTD
PMID:16497706
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases cleavage
ISO
panduratin A results in increased cleavage of CASP9 protein
CTD
PMID:16497706
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccnb1
cyclin B1
decreases expression
ISO
panduratin A results in decreased expression of CCNB1 protein
CTD
PMID:16497706
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnd1
cyclin D1
decreases expression
ISO
panduratin A results in decreased expression of CCND1 protein
CTD
PMID:16497706
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccne1
cyclin E1
decreases expression
ISO
panduratin A results in decreased expression of CCNE1 protein
CTD
PMID:16497706
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Cdc25c
cell division cycle 25C
decreases expression
ISO
panduratin A results in decreased expression of CDC25C protein
CTD
PMID:16497706
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdk1
cyclin-dependent kinase 1
decreases expression
ISO
panduratin A results in decreased expression of CDK1 protein
CTD
PMID:16497706
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
panduratin A results in decreased expression of CDK2 protein
CTD
PMID:16497706
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
panduratin A results in decreased expression of CDK4 protein
CTD
PMID:16497706
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdk6
cyclin-dependent kinase 6
decreases expression
ISO
panduratin A results in decreased expression of CDK6 protein
CTD
PMID:16497706
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
panduratin A results in increased expression of CDKN1B mRNA; panduratin A results in increased expression of CDKN1B protein
CTD
PMID:16497706
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Fadd
Fas associated via death domain
increases expression
ISO
panduratin A results in increased expression of FADD protein
CTD
PMID:16497706
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Fas
Fas cell surface death receptor
increases expression
ISO
panduratin A results in increased expression of FAS protein
CTD
PMID:16497706
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
panduratin A results in increased cleavage of PARP1 protein
CTD
PMID:16497706
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Tnfsf10
TNF superfamily member 10
increases expression
ISO
panduratin A results in increased expression of TNFSF10 protein
CTD
PMID:16497706
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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