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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Panduratin A
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Accession:CHEBI:66725 term browser browse the term
Definition:A diarylheptanoid that has formula C26H30O4.
Synonyms:related_synonym: (2,6-dihydroxy-4-methoxyphenyl)[(1R,2S,6R)-3-methyl-2-(3-methylbut-2-en-1-yl)-6-phenylcyclohex-3-en-1-yl]methanone;   Formula=C26H30O4;   InChI=1S/C26H30O4/c1-16(2)10-12-20-17(3)11-13-21(18-8-6-5-7-9-18)24(20)26(29)25-22(27)14-19(30-4)15-23(25)28/h5-11,14-15,20-21,24,27-28H,12-13H2,1-4H3/t20-,21+,24-/m1/s1;   InChIKey=LYDZCXVWCFJAKQ-ZFGGDYGUSA-N;   SMILES=COc1cc(O)c(C(=O)[C@@H]2[C@H](CC=C(C)C)C(C)=CC[C@H]2c2ccccc2)c(O)c1
 xref_mesh: MESH:C482884
 xref: PMID:15930750


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Panduratin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acin1 apoptotic chromatin condensation inducer 1 increases degradation ISO panduratin A results in increased degradation of ACIN1 protein CTD PMID:16497706 NCBI chr15:33,288,369...33,333,256
Ensembl chr15:33,288,374...33,333,417
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO panduratin A results in increased expression of BAX protein CTD PMID:16497706 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO panduratin A results in decreased expression of BCL2 protein CTD PMID:16497706 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO panduratin A results in decreased expression of BID protein CTD PMID:16497706 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 increases cleavage ISO panduratin A results in increased cleavage of CASP3 protein CTD PMID:16497706 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases cleavage ISO panduratin A results in increased cleavage of CASP6 protein CTD PMID:16497706 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 increases cleavage ISO panduratin A results in increased cleavage of CASP8 protein CTD PMID:16497706 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage ISO panduratin A results in increased cleavage of CASP9 protein CTD PMID:16497706 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO panduratin A results in decreased expression of CCNB1 protein CTD PMID:16497706 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO panduratin A results in decreased expression of CCND1 protein CTD PMID:16497706 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO panduratin A results in decreased expression of CCNE1 protein CTD PMID:16497706 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO panduratin A results in decreased expression of CDC25C protein CTD PMID:16497706 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO panduratin A results in decreased expression of CDK1 protein CTD PMID:16497706 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO panduratin A results in decreased expression of CDK2 protein CTD PMID:16497706 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO panduratin A results in decreased expression of CDK4 protein CTD PMID:16497706 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO panduratin A results in decreased expression of CDK6 protein CTD PMID:16497706 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO panduratin A results in increased expression of CDKN1B mRNA; panduratin A results in increased expression of CDKN1B protein CTD PMID:16497706 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Fadd Fas associated via death domain increases expression ISO panduratin A results in increased expression of FADD protein CTD PMID:16497706 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO panduratin A results in increased expression of FAS protein CTD PMID:16497706 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO panduratin A results in increased cleavage of PARP1 protein CTD PMID:16497706 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO panduratin A results in increased expression of TNFSF10 protein CTD PMID:16497706 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            Panduratin A 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                carbocyclic compound 18183
                                  benzenoid aromatic compound 17180
                                    diarylheptanoid 884
                                      Panduratin A 21
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.